Pub Date : 2018-06-06DOI: 10.25135/jcm.16.18.03.082
S. Oğuzkan, Bora Karagül, E. Aksoy, A. Uzun, Merve Can, H. Yılmaz, H. I. Uğraş, B. Bi̇ni̇ci̇, A. Gören
In this study, mass fractions of paclitaxel, cephalomannine, 10-DAB III and baccatin III in hazelnut were measured with new and validated LC-MS/MS method. Green outer nut husk and nutshell of Turkish hazelnut (Corylus colurna L.) were collected from Düzce, Trabzon, Adapazarı and Samsun at several altitudes during August and September in 2014. The target analytes were prepared using solid-liquid extraction and analysed by LC-MS/MS. High amount of baccatin III, used for synthesizing semi-synthetic paclitaxel, was found in the nutshells collected at 250-500 m altitude in Cumayeri district of Duzce. In the husk samples from Vakfıkebir district of Trabzon, the highest amount of baccatin III was obtained. The mass fractions of baccatin III in nutshell and husks were between 164.38-1020.85 μgkg-1 and 166.12-923.64 μgkg-1, respectively.
{"title":"Determination of taxanes by validated LC-MS/MS method in hazelnut collected from different regions and altitudes in Turkey","authors":"S. Oğuzkan, Bora Karagül, E. Aksoy, A. Uzun, Merve Can, H. Yılmaz, H. I. Uğraş, B. Bi̇ni̇ci̇, A. Gören","doi":"10.25135/jcm.16.18.03.082","DOIUrl":"https://doi.org/10.25135/jcm.16.18.03.082","url":null,"abstract":"In this study, mass fractions of paclitaxel, cephalomannine, 10-DAB III and baccatin III in hazelnut were measured with new and validated LC-MS/MS method. Green outer nut husk and nutshell of Turkish hazelnut (Corylus colurna L.) were collected from Düzce, Trabzon, Adapazarı and Samsun at several altitudes during August and September in 2014. The target analytes were prepared using solid-liquid extraction and analysed by LC-MS/MS. High amount of baccatin III, used for synthesizing semi-synthetic paclitaxel, was found in the nutshells collected at 250-500 m altitude in Cumayeri district of Duzce. In the husk samples from Vakfıkebir district of Trabzon, the highest amount of baccatin III was obtained. The mass fractions of baccatin III in nutshell and husks were between 164.38-1020.85 μgkg-1 and 166.12-923.64 μgkg-1, respectively.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-06DOI: 10.25135/JCM.14.18.02.063
S. Charapitsa, S. Sytova, Anton Korban, Nicolai Boyarin, I. Shestakovich, R. Čabala
An extensive study concerning the problem of volatile compounds determination in alcoholic products by gas chromatography has been undertaken in the paper. A row of gravimetrically prepared standard solutions was analysed with three analytical methods: traditional method of internal standard, advanced method of internal standard and external standard method. The main analytical characteristics and metrological parameters of the “Ethanol as Internal Standard” method were compared with the traditional approaches. It was shown that this method leads to correct values of volatiles concentrations and the corresponding metrological characteristics are generally better.
{"title":"The establishment of metrological characteristics of the method “Ethanol as Internal Standard” for the direct determination of volatile compounds in alcoholic products","authors":"S. Charapitsa, S. Sytova, Anton Korban, Nicolai Boyarin, I. Shestakovich, R. Čabala","doi":"10.25135/JCM.14.18.02.063","DOIUrl":"https://doi.org/10.25135/JCM.14.18.02.063","url":null,"abstract":"An extensive study concerning the problem of volatile compounds determination in alcoholic products by gas chromatography has been undertaken in the paper. A row of gravimetrically prepared standard solutions was analysed with three analytical methods: traditional method of internal standard, advanced method of internal standard and external standard method. The main analytical characteristics and metrological parameters of the “Ethanol as Internal Standard” method were compared with the traditional approaches. It was shown that this method leads to correct values of volatiles concentrations and the corresponding metrological characteristics are generally better.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47055926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-06DOI: 10.25135/JCM.13.18.04.081
I. Unsal, M. Tasan, T. Gokcen, A. Gören
In this study, an ID-LC-MS method was developed and validated for the determination of 14 sulfonamides in milk samples. Recovery results were found to be in the range of 91%-114% for milk samples. The relative measurement uncertainty was between 7.5%12.7%. Validated method was performed on milk samples obtained from market and street vendors. The amount of sulfonamides in the analyzed samples was found to be below the legal limits (Sulfamethazine: 6.46±0.76 ng/g and sulfisoxazole: 7.3±0.71 ng/g).
{"title":"Determination of sulfonamides in milk by ID-LC-MS/MS","authors":"I. Unsal, M. Tasan, T. Gokcen, A. Gören","doi":"10.25135/JCM.13.18.04.081","DOIUrl":"https://doi.org/10.25135/JCM.13.18.04.081","url":null,"abstract":"In this study, an ID-LC-MS method was developed and validated for the determination of 14 sulfonamides in milk samples. Recovery results were found to be in the range of 91%-114% for milk samples. The relative measurement uncertainty was between 7.5%12.7%. Validated method was performed on milk samples obtained from market and street vendors. The amount of sulfonamides in the analyzed samples was found to be below the legal limits (Sulfamethazine: 6.46±0.76 ng/g and sulfisoxazole: 7.3±0.71 ng/g).","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43923829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-06DOI: 10.25135/JCM.13.18.02.070
A. Gören, Gozde Sahin, İsmail Gümilcineli, B. Bi̇ni̇ci̇
{"title":"Rapid and reliable 25-OH vitamin D2 and 25-OH vitamin D3 measurements by multitasker LC-MS/MS","authors":"A. Gören, Gozde Sahin, İsmail Gümilcineli, B. Bi̇ni̇ci̇","doi":"10.25135/JCM.13.18.02.070","DOIUrl":"https://doi.org/10.25135/JCM.13.18.02.070","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46946802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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