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Isolation of amygdalin epimer at high diastereomeric purity and its structural characterization by spectroscopic and Q-TOF LC-MS methods 高非对映异构体纯度苦杏仁苷表聚体的分离及其光谱和Q-TOF LC-MS表征
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2021-08-18 DOI: 10.25135/jcm.60.2105.2076
Irfan Capan, S. Servi, A. Aysal, Pshtiwan Raheem Sabır
Amygdalin, a cyanogenic glycoside mostly found in the bitter almond kernel, plays an important role in conventional and modern medicine applications. The high diastereomeric purity amygdalin was isolated with chromatographic purification methods and recrystallization. Amygdalin and neoamygdalin were separated chromatographically using the porous graphitic carbon column. Identification and confirmation of each molecule was performed with the ESI Quadrupole Time of Flight system coupled with a reversed phase LC.
苦杏仁苷是一种主要存在于苦杏仁中的发蓝糖苷,在传统和现代医学中发挥着重要作用。采用色谱纯化和重结晶的方法分离得到高非对映体纯度的苦杏仁苷。采用多孔石墨碳柱色谱分离苦杏仁苷和新苦杏仁苷。每个分子的鉴定和确认是用ESI四极飞行时间系统与反相LC耦合进行的。
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引用次数: 1
Stability indicating liquid chromatographic method for the estimation of remogliflozin etabonate 稳定性指示的液相色谱法测定瑞格列净的含量
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-12-01 DOI: 10.25135/jcm.46.20.07.1734
D. Shah, Ishita I. Gondalia, V. Patel, Ashok Mahajan, U. Chhalotiya
: Accurate and precise reverse phase liquid chromatographic method has been developed for the estimation Remogliflozin etabonate in bulk and tablet dosage form. Reverse phase C18 column was used as stationary phase along with mixture of methanol:water (70:30%, v/v) as a mobile phase. Mobile phase flow rate was maintained at 1mL/min and analysis was performed at 229 nm. The method was linear in the concentration range of 1 – 25 μg/mL with correlation coefficient (r 2 ) 0.997. The proposed method was validated with respect to linearity, accuracy, precision and robustness as per ICH Q2 (R1) guideline. To find out the possible degradation pathway, forced degradation studies were performed. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time value. The drug was found to be highly susceptible to acid and base hydrolysis. The developed method can be used for analysis of stability samples and routing quality control evaluation of Remogliflozin etabonate in
建立了准确、精确的反相液相色谱法测定安他巴酸雷莫列净散装剂型和片剂剂型的含量。以反相C18柱为固定相,甲醇:水(70:30%,v/v)为流动相。流动相流速保持在1mL/min,在229 nm进行分析。该方法在1 ~ 25 μg/mL浓度范围内线性良好,相关系数(r 2) 0.997。根据ICH Q2 (R1)指南对该方法进行了线性、准确度、精密度和鲁棒性验证。为了找出可能的降解途径,进行了强制降解研究。降解产物峰与纯药峰分离较好,保留时间差异显著。这种药物被发现对酸碱水解非常敏感。该方法可用于盐酸雷莫列净的稳定性样品分析和路线质量控制评价
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引用次数: 16
Determination of doxylamine from a tea sample: A claim of drug facilitated crime 茶叶样品中多西胺的测定:毒品促进犯罪的主张
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-06-10 DOI: 10.25135/jcm.40.20.04.1634
M. Kuloglu, T. Tekin, Zeynep Türkmen, Y. T. Demircan, S. Mercan
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引用次数: 0
Development of a densitometric HPTLC method for determination of 5-HMF in fruit-based baby foods in Turkey 密度计HPTLC法测定土耳其水果类婴儿食品中5-HMF
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-06-10 DOI: 10.25135/jcm.39.20.05.1653
Zeynep Turkmen
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引用次数: 1
Primary level electrolytic conductivity measurements at National Metrology Institute of Turkey (TUBITAK UME) 土耳其国家计量研究所(TUBITAK UME)初级电解电导率测量
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-06-10 DOI: 10.25135/jcm.34.20.01.1524
E. Uysal, L. Liv, F. Fiçicioǧlu, M. Arifoviç
TUBITAK UME (National Metrology Institute of Turkey) Electrochemistry Laboratory established the primary level electrolytic conductivity measurement system in 2018. The objective of this work is to prove the accuracy of the established system with an acceptable uncertainty and to disseminate the traceability for electrolytic conductivity measurements. While the accuracy of the system was tested with the certified conductivity solutions, the accuracy of the software developed at TUBITAK UME was also tested. The cell constant was determined as 0.57986 cm at 25 °C by using certified conductivity solutions. The accuracy of the system was evaluated using the measurement of certified conductivity solutions and it was found that there was no significant difference between the results at 95% confidence level. Finally, “Evaluation of measurement data Guide to the expression of uncertainty in measurement” and “EA-4/02 M: 2013 Evaluation of the Uncertainty of Measurement in Calibration” guides were used to form the uncertainty budget for primary level electrolytic conductivity measurements.
TUBITAK UME(土耳其国家计量研究所)电化学实验室于2018年建立了初级电解电导率测量系统。这项工作的目的是在可接受的不确定度下证明所建立系统的准确性,并传播电解电导率测量的可追溯性。在用经认证的电导率溶液测试系统精度的同时,还测试了TUBITAK UME开发的软件的精度。通过使用经认证的电导率溶液,在25°C下确定电池常数为0.57986cm。使用经认证的电导率溶液的测量来评估系统的准确性,发现在95%置信水平下,结果之间没有显著差异。最后,使用“测量数据评估——测量不确定度表达指南”和“EA-4/02M:2013校准测量不确定性评估”指南来形成一级电解电导率测量的不确定度预算。
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引用次数: 1
Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS hplc -MS/MS法测定膳食补充剂中掺假的二氢辣椒素
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-06-10 DOI: 10.25135/jcm.36.20.01.1532
Demet Di̇nçel, Hatice Olgan, Zeynep Canbaloğlu, S. Yalçin, A. Erkuçuk, Gizem Tırıs, A. Gören
Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 μm) column at 25 °C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.
膳食补充剂掺假严重威胁着世界各地的公众健康。如今,为了从自然疗法中获得预期的效果,通过人工或有害化学物质掺假的天然产品正在增加。hplc -MS/MS快速测定膳食补充剂中辣椒素和二氢辣椒素的方法在流动相a(1%甲酸溶液和0.1%甲酸铵水溶液)和B(1%甲酸溶液和0.1%甲酸铵甲醇)的混合物中,以梯度程序,流速为0.35 mL/min,在25°C下建立了3 μm)的色谱柱并进行了验证。所建立的方法对辣椒素的回收率为95.4 ~ 106.3,对二氢辣椒素的回收率为96.3 ~ 108.9。本研究表明,合成复合二氢辣椒素被广泛应用于膳食补充剂产品中,在没有任何声明的情况下进行掺假,以增加产品的效果。
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引用次数: 5
Determination of secondary metabolites of Origanum vulgare subsp. hirtum and O. vulgare subsp. vulgare by LC-MS/MS 牛至次级代谢产物的测定。汗毛和O.vulgare亚种。LC-MS/MS法
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-06-10 DOI: 10.25135/jcm.33.20.04.1610
Züleyha Özer, S. Carikci, H. Yılmaz, T. Kilic, T. Dirmenci, A. Gören
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引用次数: 14
Importance of sample pretreatment step on the bacterial toxicity bioassay of ZnO nanoparticles 样品预处理步骤对ZnO纳米粒子细菌毒性生物测定的重要性
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2020-06-10 DOI: 10.25135/jcm.37.20.03.1583
A. Baysal, H. Saygin, G. Ustabasi
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引用次数: 1
Investigation of caffeine concentrations in sport supplements and inconsistencies in product labelling 运动补充剂中咖啡因浓度的调查和产品标签的不一致
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2019-06-23 DOI: 10.25135/JCM.25.19.04.1252
Eda Okuroglu, T. Tekin, M. Kuloglu, S. Mercan, I. Bavunoğlu, M. Acıkkol, Zeynep Türkmen
Caffeine is a substance that can be easily consumed in daily nutrition as well as in sport supplements. Exceeding the daily-recommended dose for caffeine may cause serious health problems. Studies illustrated that many concerns have been raising about the incompatibility between labels on sport supplements and their contents. The present study aimed to investigate caffeine contents in sport supplements purchased from Turkey market for the first time and to evaluate label information on products. Caffeine concentrations were determined in 41 sport supplements and possible adverse effects were emphasized considering calculated daily consumption doses. Seventeen samples among 41 products were found to be caffeine containing, ranging from 4.52 to 471 mg/mL. Three of caffeine containing products were undeclared their caffeine ingredients. Although three products were not specified caffeine their amounts, findings were found above the daily-recommended caffeine limit (400 mg/day). Significant differences were observed between the quantities indicated on the labels and the determined caffeine amounts in 7 products (p<0.05). Eight of 17 caffeine labelled products were found between 151-948% higher than stated label information. Overall, 29.4% of caffeine containing products (n=17) were found over the recommended intake. Consuming more than the daily-recommended dose may cause severe adverse reactions and consumers may experience serious health risks such as arterial hypertension, coronary heart disease, as well as sleep problems, irritability, anxiety, headache, and restlessness. Considering these health risks, awareness of consumers and accurate product labels on sport supplements gain more importance to prevent people from undesired consequences.
咖啡因是一种很容易在日常营养和运动补充剂中摄入的物质。超过每日推荐的咖啡因剂量可能会导致严重的健康问题。研究表明,人们对运动补充剂标签与其内容之间的不相容性提出了许多担忧。本研究旨在调查首次从土耳其市场购买的运动补充剂中的咖啡因含量,并评估产品的标签信息。对41种运动补充剂中的咖啡因浓度进行了测定,并考虑到计算的每日消耗剂量,强调了可能的不良影响。41种产品中有17种样品被发现含有咖啡因,含量从4.52到471毫克/毫升不等。三种含有咖啡因的产品未申报其咖啡因成分。尽管有三种产品没有具体说明咖啡因的含量,但发现其含量超过了每日推荐的咖啡因限量(400毫克/天)。标签上显示的数量与7种产品中确定的咖啡因数量之间存在显著差异(p<0.05)。17种咖啡因标签产品中有8种比标签信息高151-948%。总体而言,29.4%的含咖啡因产品(n=17)超过了建议摄入量。摄入超过每日推荐剂量可能会导致严重的不良反应,消费者可能会面临严重的健康风险,如动脉高压、冠心病,以及睡眠问题、易怒、焦虑、头痛和烦躁不安。考虑到这些健康风险,消费者的意识和运动补充剂上准确的产品标签对于防止人们遭受不良后果变得更加重要。
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引用次数: 2
Determination of some heavy metals by ICP-OES in edible parts of fish from Sapanca Lake and streams ICP-OES法测定萨潘卡湖和溪流鱼类可食用部位中的某些重金属
IF 1.3 Q3 CHEMISTRY, ANALYTICAL Pub Date : 2019-06-23 DOI: 10.25135/JCM.24.19.03.1219
H. Altundağ, E. Yıldırım, Esra Altintig
In this study, 20 fish taken from Sapanca Lake, Sakarya River and Western Black Sea (Karasu) in total and heavy metal accumulation (Cu, Fe abd Zn) in the muscles of 15 species was determined with ICP-OES (Inductively Coupled Plasma-Optical Emission Spectometer) device. When the results were examined, Cu, Fe and Zn concentration was determined to be 2.60-5.31 μg/g, 0.25-54.36 μg/g and 13.66-47.11 μg/g respectively in fish samples. In addition, the same procedures were applied with the standard reference material DORM-3 reference material (Fish Protein Certified Reference Material for Trace Metals) to determine the accuracy of the method. As a result, it has been determined that the amount of heavy metals contained in the analyzed fish samples is below the limit values provided by the Turkish Food Codex, Food and Agriculture Organization and World Health Organization and therefore consumption of these does not constitute a threat to health.
本研究采用电感耦合等离子体发射光谱计(ICP-OES)测定了从萨潘卡湖、萨卡里亚河和西黑海(Karasu)采集的20条鱼的总含量和15种鱼类肌肉中重金属(Cu、Fe和Zn)的积累。当检测结果时,鱼类样品中的Cu、Fe和Zn浓度分别为2.60-5.31μg/g、0.25-54.36μg/g和13.66-47.11μg/g。此外,对标准参考物质DORM-3参考物质(微量金属鱼类蛋白认证参考物质)采用相同的程序来确定该方法的准确性。因此,已确定所分析的鱼类样本中所含的重金属含量低于土耳其食品法典、粮食及农业组织和世界卫生组织提供的限值,因此食用这些重金属不会对健康构成威胁。
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引用次数: 4
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Journal of Chemical Metrology
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