Objective: Capacitive-Resistive Electrothermal Therapies (CRET) have proven effective in tissue regeneration. This study analyzes the response to 448-kHz CRET treatment in 20 patients with Female Pattern Hair Loss (FPHL) and in woman’s Dermal Papilla Cells (DPC). Methods: Patients received ten 20-minute CRET sessions over an 8-week interval. Three months after the last session, the effects of the treatment were trichoscopically analysed. DPC were CRET stimulated intermittently for 12, 24 or 48 h and the effects on cell proliferation and expression of several proteins involved in cell proliferation were analysed. Results: Trichoscopic data revealed generalized, statistically significant hair redensification (10 – 15 % over pre-treatment values) in all the treated scalp areas. In-vitro electrostimulation significantly increased DPC proliferation and expression of the proteins involved in cell proliferation. Since dysregulation of DPC proliferation is the main factor underlying abnormal hair loss, it is likely that electrically-induced DPC proliferation is involved in the redensifying effects obtained in the trichological study. Conclusion: The results of the trichological study in FPHL patients and those of the experimental study in woman’s DPC are consistent with each other and suggest that 448-kHz CRET could be effective both for hair redensification and hair loss prevention.
{"title":"Radiofrequency Current at 448 Khz For Female Pattern Hair Loss: Cellular Bases For Redensification Improvement","authors":"N. Pablo","doi":"10.46889/jdr.2022.3209","DOIUrl":"https://doi.org/10.46889/jdr.2022.3209","url":null,"abstract":"Objective: Capacitive-Resistive Electrothermal Therapies (CRET) have proven effective in tissue regeneration. This study analyzes the response to 448-kHz CRET treatment in 20 patients with Female Pattern Hair Loss (FPHL) and in woman’s Dermal Papilla Cells (DPC).\u0000\u0000Methods: Patients received ten 20-minute CRET sessions over an 8-week interval. Three months after the last session, the effects of the treatment were trichoscopically analysed. DPC were CRET stimulated intermittently for 12, 24 or 48 h and the effects on cell proliferation and expression of several proteins involved in cell proliferation were analysed.\u0000\u0000Results: Trichoscopic data revealed generalized, statistically significant hair redensification (10 – 15 % over pre-treatment values) in all the treated scalp areas. In-vitro electrostimulation significantly increased DPC proliferation and expression of the proteins involved in cell proliferation. Since dysregulation of DPC proliferation is the main factor underlying abnormal hair loss, it is likely that electrically-induced DPC proliferation is involved in the redensifying effects obtained in the trichological study.\u0000\u0000Conclusion: The results of the trichological study in FPHL patients and those of the experimental study in woman’s DPC are consistent with each other and suggest that 448-kHz CRET could be effective both for hair redensification and hair loss prevention.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78803068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Based on analysis of published data of incidence of melanoma, basal cell carcinoma and squamous cell carcinoma from 2 large prospective cohort studies involving about 120,000 health workers in USA, excellent linear relationships between skin cancer incidence and Severe Sunburn (SS) incidence suggesting their causal association were found. It is postulated that the SS-caused UV radiation overwhelms the skin cell’s capacity to repair/remove DNA lesions (about 70,000 non-cumulative lesions per day) and any of these un-repaired/un-removed lesions can eventually become a pre-cancerous tumor or cancer after overcoming numerous barriers of body’s repair/defense mechanisms. The above rationale for cancer etiology seems consistent with the classical wound-to-tumor doctrine. Infection with Human Papillomavirus will reduce the threshold for non-cumulative DNA lesions thereby facilitating cancer initiation. The proposed SS theory may be generally applicable to people with different races, skin types, hair colors and sunlight exposures. The proposed non-cumulative UV damage concept is supported by published data showing parallel first-order aging kinetics of human skin being exposed and un-exposed to sunlight in ordinary people. Solar UVA only plays a minor or insignificant role in skin cancer and premature aging. Prevalence of SS is reviewed. Controversies on skin cancer risks for indoor and outdoor workers such as airplane pilots and crew, health workers, gardeners and truck drivers are discussed. Potential shortcomings of a common practice of using highly unphysiological UV, UVA or UVB doses in animal, cell culture or human skin studies are discussed. Demonstration resembling the reversibility of intrinsic skin aging using a plant deprived of and then replenished with water is presented. It is hoped that this apparently provocative work may stimulate further discussions in the literature.
{"title":"Severe Sunburn Triggers the Development of Skin Cancers: Non-cumulative/Overwhelming UV Damages, UVA Rays, Human Papillomavirus, Indoor/Outdoor Workers and Animal Models","authors":"W. L. Chiou","doi":"10.46889/jdr.2022.3208","DOIUrl":"https://doi.org/10.46889/jdr.2022.3208","url":null,"abstract":"Based on analysis of published data of incidence of melanoma, basal cell carcinoma and squamous cell carcinoma from 2 large prospective cohort studies involving about 120,000 health workers in USA, excellent linear relationships between skin cancer incidence and Severe Sunburn (SS) incidence suggesting their causal association were found. It is postulated that the SS-caused UV radiation overwhelms the skin cell’s capacity to repair/remove DNA lesions (about 70,000 non-cumulative lesions per day) and any of these un-repaired/un-removed lesions can eventually become a pre-cancerous tumor or cancer after overcoming numerous barriers of body’s repair/defense mechanisms. The above rationale for cancer etiology seems consistent with the classical wound-to-tumor doctrine. Infection with Human Papillomavirus will reduce the threshold for non-cumulative DNA lesions thereby facilitating cancer initiation. The proposed SS theory may be generally applicable to people with different races, skin types, hair colors and sunlight exposures. The proposed non-cumulative UV damage concept is supported by published data showing parallel first-order aging kinetics of human skin being exposed and un-exposed to sunlight in ordinary people. Solar UVA only plays a minor or insignificant role in skin cancer and premature aging. Prevalence of SS is reviewed. Controversies on skin cancer risks for indoor and outdoor workers such as airplane pilots and crew, health workers, gardeners and truck drivers are discussed. Potential shortcomings of a common practice of using highly unphysiological UV, UVA or UVB doses in animal, cell culture or human skin studies are discussed. Demonstration resembling the reversibility of intrinsic skin aging using a plant deprived of and then replenished with water is presented. It is hoped that this apparently provocative work may stimulate further discussions in the literature.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75242885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite the revolution represented by biologic drugs, it is safe to say that every dermatologist has known the frustrating experience of treating a “difficult” patient with psoriasis. Such patients may have been treated with numerous drugs, never achieving long-term disease control. We hereby present the case of a patient who, despite having been treated, over the course of 15 years, with 7 biologics and 3 traditional systemic agents, has never experienced lasting remission. We also discuss hypothetical reasons for these repeated treatment failures: while obesity and ANA positivity could have contributed significantly, a third, more complex, factor may be to blame. It is possible that frequently switching to the newest drug available, due to lack of other therapeutic options, interfered with the pathogenetic phenotype of the patient, and, consequently, with the response to other biologics. This disheartening and fascinating hypothesis clearly needs to be investigated, in the hope of finding solutions for all seemingly impossible-to-treat patients.
{"title":"The Risk of Creating Difficult-To-Treat Psoriasis by Switching Multiple Biologic Therapies: A Case Report and Relative Considerations","authors":"M. Burlando, I. Salvi, E. Cozzani, A. Parodi","doi":"10.46889/jdr.2022.3102","DOIUrl":"https://doi.org/10.46889/jdr.2022.3102","url":null,"abstract":"Despite the revolution represented by biologic drugs, it is safe to say that every dermatologist has known the frustrating experience of treating a “difficult” patient with psoriasis. Such patients may have been treated with numerous drugs, never achieving long-term disease control. We hereby present the case of a patient who, despite having been treated, over the course of 15 years, with 7 biologics and 3 traditional systemic agents, has never experienced lasting remission. We also discuss hypothetical reasons for these repeated treatment failures: while obesity and ANA positivity could have contributed significantly, a third, more complex, factor may be to blame. It is possible that frequently switching to the newest drug available, due to lack of other therapeutic options, interfered with the pathogenetic phenotype of the patient, and, consequently, with the response to other biologics. This disheartening and fascinating hypothesis clearly needs to be investigated, in the hope of finding solutions for all seemingly impossible-to-treat patients.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89561637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report the clinical characteristics and management of two patients with severe PF, who presented with extreme pruritus and high IgE levels. Both the two patients had common characteristics as follows 1. They were all diagnosed as PF and presented with chronic eczematous lesions 2. The patients all accompanied with intense pruritus and were resistant to diversified forms of antihistamines. Furthermore, the level of IgE antibody in their serum was significantly increased 3. Their skin lesions were accompanied with Staphylococcus aureus infection by secretion culture 4. After the diagnosis of PF was made, methylprednisolone (1.5 mg/kg) and antibiotics were administered, which rapidly induced remission and the levels of Dsg1 and IgE in the serum were significantly declined. The possible role and mechanism of IgE elevation in these two cases were also discussed
{"title":"Two Cases of Pemphigus Foliaceus with Severe Pruritus and Elevated IgE Levels","authors":"Jingfang Zhang, Liu Yang, Yamin Zhang, Juan Tao","doi":"10.46889/jdr.2022.3101","DOIUrl":"https://doi.org/10.46889/jdr.2022.3101","url":null,"abstract":"We report the clinical characteristics and management of two patients with severe PF, who presented with extreme pruritus and high IgE levels. Both the two patients had common characteristics as follows 1. They were all diagnosed as PF and presented with chronic eczematous lesions 2. The patients all accompanied with intense pruritus and were resistant to diversified forms of antihistamines. Furthermore, the level of IgE antibody in their serum was significantly increased 3. Their skin lesions were accompanied with Staphylococcus aureus infection by secretion culture 4. After the diagnosis of PF was made, methylprednisolone (1.5 mg/kg) and antibiotics were administered, which rapidly induced remission and the levels of Dsg1 and IgE in the serum were significantly declined. The possible role and mechanism of IgE elevation in these two cases were also discussed","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83757323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9554.21.12.551
D. Kalman, S. Hewlings
Introduction: Age related changes in hair and skin impact quality of life. Interventions to mitigate these changes are of interest. Aim: To examine the safety and efficacy of LustrivaTM (a novel source of biotin and silicon) at a high or lower dose compared to placebo for impacts on hair and skin. Materials and Methods: In a randomized, double-blind study, 90 healthy female subjects with self-reported thinning hair who met Savin/Ludwig Scale criteria I-2 to II-1 by physician evaluation were randomized to one of three groups for 12 weeks (n=30/group): LustrivaTM High-Dose (LHD), LustrivaTM Low-Dose (LLD) or Placebo (PL). Hair quality and thickness measured by the TrichoScan HD testing system and skin parameters (facial wrinkles, fine lines, skin texture, skin color evenness, skin elasticity) measured by the Antera 3DTM System and the CutometerTM Dual MPA 580 system. Results: There was a significant increase in hair thickness measured by change in % vellus hair and % terminal hair and in the ratio of % vellus to terminal hair in LHD compared to PL at Week 3, maintained throughout the study (p=0.029). LHD had a significant decrease in facial wrinkles (12 Weeks) measured by a change in maximal wrinkle depth vs. PL (p=0.031). After 12 weeks compared to baseline LHD significantly improved facial wrinkle Maximum Depth, Indentation Index and Score, facial fine lines Indentation Index and Score, and facial texture Maximum Height, Roughness and Score (p<0.05), no change in PL. There were no changes for skin elasticity between groups. For some hair and skin parameters, LLD showed improvements less than LHD but that approached significance (p<0.1). All groups improved in subjective nail endpoints vs. baseline with no significant differences between groups. No adverse events reported. Conclusion: LHD significantly increased hair thickness and reduced facial wrinkle depth compared to placebo and performed better than the LLD in most parameters. Future studies are warranted.
{"title":"A Randomized Double-Blind Evaluation of a Novel Biotin and Silicon Ingredient Complex on the Hair and Skin of Healthy Women","authors":"D. Kalman, S. Hewlings","doi":"10.35248/2155-9554.21.12.551","DOIUrl":"https://doi.org/10.35248/2155-9554.21.12.551","url":null,"abstract":"Introduction: Age related changes in hair and skin impact quality of life. Interventions to mitigate these changes are of interest. Aim: To examine the safety and efficacy of LustrivaTM (a novel source of biotin and silicon) at a high or lower dose compared to placebo for impacts on hair and skin. Materials and Methods: In a randomized, double-blind study, 90 healthy female subjects with self-reported thinning hair who met Savin/Ludwig Scale criteria I-2 to II-1 by physician evaluation were randomized to one of three groups for 12 weeks (n=30/group): LustrivaTM High-Dose (LHD), LustrivaTM Low-Dose (LLD) or Placebo (PL). Hair quality and thickness measured by the TrichoScan HD testing system and skin parameters (facial wrinkles, fine lines, skin texture, skin color evenness, skin elasticity) measured by the Antera 3DTM System and the CutometerTM Dual MPA 580 system. Results: There was a significant increase in hair thickness measured by change in % vellus hair and % terminal hair and in the ratio of % vellus to terminal hair in LHD compared to PL at Week 3, maintained throughout the study (p=0.029). LHD had a significant decrease in facial wrinkles (12 Weeks) measured by a change in maximal wrinkle depth vs. PL (p=0.031). After 12 weeks compared to baseline LHD significantly improved facial wrinkle Maximum Depth, Indentation Index and Score, facial fine lines Indentation Index and Score, and facial texture Maximum Height, Roughness and Score (p<0.05), no change in PL. There were no changes for skin elasticity between groups. For some hair and skin parameters, LLD showed improvements less than LHD but that approached significance (p<0.1). All groups improved in subjective nail endpoints vs. baseline with no significant differences between groups. No adverse events reported. Conclusion: LHD significantly increased hair thickness and reduced facial wrinkle depth compared to placebo and performed better than the LLD in most parameters. Future studies are warranted.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"15 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84907025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9554.21.12.554
R. Kalantari, S. Soleimanifard, M. Soleimani-Ahmadi, Rasool Jafari, M. Abtahi
Purpose: Scabies is a common parasitic infestation caused by the permanent parasite of human. Infestation occurs when the "itchy" mite, S. scabiei, penetrates the skin and eats the epidermis of the host. This infestation is a major problem that occurs in many indigenous communities and less developed countries in both sexes. Information about the prevalence of this disease in Iran is low. Thus this study aimed to determine the future of infestation in Isfahan. Methods: 283 patients with clinical futures of scabies, who were examined by a dermatologist, from different medical centers in Isfahan, were assayed. Sampling was performed directly from the epidermis with mineral oil on the newest nodules by a scalpel blade. The specimens were examined by microscope with low and high magnification to confirm the infestation and then the results were analyzed by SPSS software v.23. Results: With the microscopic examination, 86 (72.3%) out of 119 males and 100 (64.1%) out of 156 females with clinical futures of scabies indeed had the disease yet there was no significant statistical difference in the infestation rate with the sexes (p=0.096). Among the occupations, the highest level of infestation was observed in Artisan, 10 (71.4%) out of 14. No significant difference was observed among different occupations and the infestation rate (p=0.97). Conclusion: The frequency of the disease in Isfahan is high, but for a more accurate assessment of the disease, more studies with the same methodology should be done to take appropriate health measures for this disease.
{"title":"Study on the Prevalence of Scabies among Patients with Clinical Futures of the Disease in Isfahan, Iran","authors":"R. Kalantari, S. Soleimanifard, M. Soleimani-Ahmadi, Rasool Jafari, M. Abtahi","doi":"10.35248/2155-9554.21.12.554","DOIUrl":"https://doi.org/10.35248/2155-9554.21.12.554","url":null,"abstract":"Purpose: Scabies is a common parasitic infestation caused by the permanent parasite of human. Infestation occurs when the \"itchy\" mite, S. scabiei, penetrates the skin and eats the epidermis of the host. This infestation is a major problem that occurs in many indigenous communities and less developed countries in both sexes. Information about the prevalence of this disease in Iran is low. Thus this study aimed to determine the future of infestation in Isfahan. Methods: 283 patients with clinical futures of scabies, who were examined by a dermatologist, from different medical centers in Isfahan, were assayed. Sampling was performed directly from the epidermis with mineral oil on the newest nodules by a scalpel blade. The specimens were examined by microscope with low and high magnification to confirm the infestation and then the results were analyzed by SPSS software v.23. Results: With the microscopic examination, 86 (72.3%) out of 119 males and 100 (64.1%) out of 156 females with clinical futures of scabies indeed had the disease yet there was no significant statistical difference in the infestation rate with the sexes (p=0.096). Among the occupations, the highest level of infestation was observed in Artisan, 10 (71.4%) out of 14. No significant difference was observed among different occupations and the infestation rate (p=0.97). Conclusion: The frequency of the disease in Isfahan is high, but for a more accurate assessment of the disease, more studies with the same methodology should be done to take appropriate health measures for this disease.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"59 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85733500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9554.21.12.563
K. Jones
A skin disease, also known as cutaneous condition, is any medical condition that affects the integumentary systemthe organ system that encloses the body and involves skin, hair, nails, and associated muscle and glands. The main feature of this device is as a buffer against the external world. Skin disease, any of the diseases or disorders that affect the human skin. They have a wide range of cause’s skin rash caused by Lyme disease rashes and hives, for example, are visible changes in the texture of the skin that may indicate a severe disease.
{"title":"Rare Skin Diseases: Treatment and Diagnosis","authors":"K. Jones","doi":"10.35248/2155-9554.21.12.563","DOIUrl":"https://doi.org/10.35248/2155-9554.21.12.563","url":null,"abstract":"A skin disease, also known as cutaneous condition, is any medical condition that affects the integumentary systemthe organ system that encloses the body and involves skin, hair, nails, and associated muscle and glands. The main feature of this device is as a buffer against the external world. Skin disease, any of the diseases or disorders that affect the human skin. They have a wide range of cause’s skin rash caused by Lyme disease rashes and hives, for example, are visible changes in the texture of the skin that may indicate a severe disease.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"13 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86095785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9554.21.S10.573
Waleed Alajroush, Alanoud Al-Marzoug, Lina Bayazeed, Abdulrahman A Al-Rasheed, Nouf Alqahtani, F. Zulian
Congenital Localized Scleroderma (CLS), is an exceedingly rare form of morphea. Little is known about CLS clinical presentation and progression. Here we describe a case with a unique presentation of CLS noticed since birth. A 2- month-old baby girl presenting with an asymptomatic slightly hyperpigmented oval patch with hypertrophic center and mildly indurated borders involving the left forehead. She had no history of extra-cutaneous involvement. A skin biopsy was obtained and a diagnosis of CLS, circumscribed subtype, was made. Basic laboratory tests, radiological imaging, and ophthalmic examination were all unremarkable, excluding extracutaneous involvement. The patient was started on Topical Tacrolimus 0.1% ointment twice daily. After 12 months of follow-up, the lesion was stable with no signs of activity. This case represented a diagnostic challenge suggesting that CLS should be considered in the differential diagnosis of neonates or infants with fibrotic lesions to avoid delay in the diagnosis, to rule out any underlying systemic involvement, and allow prompt therapy.
{"title":"Congenital Localized Scleroderma: A Rare Presentation in a Newborn Baby","authors":"Waleed Alajroush, Alanoud Al-Marzoug, Lina Bayazeed, Abdulrahman A Al-Rasheed, Nouf Alqahtani, F. Zulian","doi":"10.35248/2155-9554.21.S10.573","DOIUrl":"https://doi.org/10.35248/2155-9554.21.S10.573","url":null,"abstract":"Congenital Localized Scleroderma (CLS), is an exceedingly rare form of morphea. Little is known about CLS clinical presentation and progression. Here we describe a case with a unique presentation of CLS noticed since birth. A 2- month-old baby girl presenting with an asymptomatic slightly hyperpigmented oval patch with hypertrophic center and mildly indurated borders involving the left forehead. She had no history of extra-cutaneous involvement. A skin biopsy was obtained and a diagnosis of CLS, circumscribed subtype, was made. Basic laboratory tests, radiological imaging, and ophthalmic examination were all unremarkable, excluding extracutaneous involvement. The patient was started on Topical Tacrolimus 0.1% ointment twice daily. After 12 months of follow-up, the lesion was stable with no signs of activity. This case represented a diagnostic challenge suggesting that CLS should be considered in the differential diagnosis of neonates or infants with fibrotic lesions to avoid delay in the diagnosis, to rule out any underlying systemic involvement, and allow prompt therapy.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"36 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84638830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Re-analysis of published data from two large prospective cohort studies by Wu, et al., probably provides the hitherto most unequivocal evidence that Severe Sunburn (SS) was an overwhelming risk factor (>90%) for all incidences of melanoma, Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) in both men and women. It is found, for example, that experiencing 1-5 and ≥ 6 SSs increased one’s risk for melanoma in men by 12.7-fold and 22fold, respectively. Since use of sunscreen during intense intermittent sun exposure can cause unintended SS, a false security phenomenon, sunscreen can be postulated as a potential major risk factor for causing skin cancers. Because chronic exposure to non-burning sunlight is protective against melanoma and can enhance immunity, this protective effect may also likely occur with less serious BCC and SCC. Therefore, regular exposure to non-burning sunlight may serve as a new strategy for skin cancer prevention and general health promotion. It is theorized that in addition to immunity enhancement, regular exposure to non-burning sunlight can result in skin tanning that will protect against sunburn and thereby protect against skin cancer. The role of erythema, a mild sunburn, in cancer incidences may be relatively limited. Since skin aging in ordinary people may be predominantly caused by the intrinsic factor, and SS is predominantly caused by intense ultraviolet (UV) B rays, the need of using broadspectrum sunscreens or organic sunscreen ingredients for protection against UVA may need to be re-considered.
{"title":"Severe Sunburn as the Overwhelming Risk Factor for 3 Common Skin Cancers: New Prevention Strategy","authors":"W. L. Chiou","doi":"10.46889/jdr.2021.2305","DOIUrl":"https://doi.org/10.46889/jdr.2021.2305","url":null,"abstract":"Re-analysis of published data from two large prospective cohort studies by Wu, et al., probably provides the hitherto most unequivocal evidence that Severe Sunburn (SS) was an overwhelming risk factor (>90%) for all incidences of melanoma, Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) in both men and women. It is found, for example, that experiencing 1-5 and ≥ 6 SSs increased one’s risk for melanoma in men by 12.7-fold and 22fold, respectively. Since use of sunscreen during intense intermittent sun exposure can cause unintended SS, a false security phenomenon, sunscreen can be postulated as a potential major risk factor for causing skin cancers. Because chronic exposure to non-burning sunlight is protective against melanoma and can enhance immunity, this protective effect may also likely occur with less serious BCC and SCC. Therefore, regular exposure to non-burning sunlight may serve as a new strategy for skin cancer prevention and general health promotion. It is theorized that in addition to immunity enhancement, regular exposure to non-burning sunlight can result in skin tanning that will protect against sunburn and thereby protect against skin cancer. The role of erythema, a mild sunburn, in cancer incidences may be relatively limited. Since skin aging in ordinary people may be predominantly caused by the intrinsic factor, and SS is predominantly caused by intense ultraviolet (UV) B rays, the need of using broadspectrum sunscreens or organic sunscreen ingredients for protection against UVA may need to be re-considered.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90472375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9554.21.S8.538
Clara Balzer, Alex, er Hapfelmeier, E. Zink, T. Biedermann, B. Eberlein
The association with the intake of thiazide medication and an increased photosensitivity was investigated by testing 15 patients on thiazide medication and 15 controls with stepwise UVA-, UVB- and UVB 311 nm-irradiation. Erythema and blood flow 24 h after irradiation were quantified by visual assessment (MED) and objective methods (Dermacatch, Minolta Chromameter, laser doppler flowmetry). A higher UVA-photosensitivity in patients taking thiazides was found by visual assessment. The sensitivity and specifity of the different devices was compared; objective measurement of erythema in all chosen wavelengths generally showed the best results with laser doppler flowmetry closely followed by colorimetry. Phototherapy in patients on thiazide medication should be carried out with caution since many factors of pharmacologically increased photosensitivity are still not explored, but it can be assumed that for the frequently used UVB 311 nm phototherapy no special precautions need to be taken.
{"title":"Quantification of UV-Induced Skin Erythema before Phototherapy in Individuals taking Hydrochlorothiazide and Controls","authors":"Clara Balzer, Alex, er Hapfelmeier, E. Zink, T. Biedermann, B. Eberlein","doi":"10.35248/2155-9554.21.S8.538","DOIUrl":"https://doi.org/10.35248/2155-9554.21.S8.538","url":null,"abstract":"The association with the intake of thiazide medication and an increased photosensitivity was investigated by testing 15 patients on thiazide medication and 15 controls with stepwise UVA-, UVB- and UVB 311 nm-irradiation. Erythema and blood flow 24 h after irradiation were quantified by visual assessment (MED) and objective methods (Dermacatch, Minolta Chromameter, laser doppler flowmetry). A higher UVA-photosensitivity in patients taking thiazides was found by visual assessment. The sensitivity and specifity of the different devices was compared; objective measurement of erythema in all chosen wavelengths generally showed the best results with laser doppler flowmetry closely followed by colorimetry. Phototherapy in patients on thiazide medication should be carried out with caution since many factors of pharmacologically increased photosensitivity are still not explored, but it can be assumed that for the frequently used UVB 311 nm phototherapy no special precautions need to be taken.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"24 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73907029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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