Journal of clinical & experimental dermatology research最新文献

{"title":"Pigmentation of basal cell carcinoma is inversely associated with tumor aggressiveness in Asian patients","authors":"Hye-Rim Moon","doi":"10.4172/2155-9554-C10-096","DOIUrl":"https://doi.org/10.4172/2155-9554-C10-096","url":null,"abstract":"","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88225626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Giant Buschke-Löwenstein Tumor","authors":"Sara Mai, S. Baya, S. Maouni, K. Znati, J. Hafidi, A. Abbassi, K. Senouci","doi":"10.35248/2155-9554.19.10.512","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.512","url":null,"abstract":"A 70-year-old man with no notable medical history presented to our department with a huge tumor on his pubic area that had been evolving for over 20 years causing itching and foul smelling discharge. Physical examination revealed a cauliflower-like voluminous tumor on the patient’s pubis with extension to the penoscrotal area and the lower abdomen (Figure 1).","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"46 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74018214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detoxsan® Paste Formulation Containing Zeolites for the Treatment of Mycosis and Intertrigo Carried Out Under Climatic Conditions of Cuba","authors":"A. Torres, Yamile Sanchez, W. Dathe","doi":"10.4172/2155-9554.1000485","DOIUrl":"https://doi.org/10.4172/2155-9554.1000485","url":null,"abstract":"Objective: To offer an alternative therapy for the treatment of mycosis and intertrigo by a well investigated natural zeolite mineral embedded in a formulation of petrolatum and squalane. Methods: A total of 43 patients, who were suffering from mycosis and intertrigo in the period started from July 2nd and ended on September 29th in 2018, were treated at the Policlinico Julio Grave de Peralta and dialysis department of the Hospital V. I. Lenin. Among them, 31 patients agreed with the application of the alternative therapy with Detoxsan® paste to overcome these dermatological diseases. The paste was applied semi-daily to the skin damaged by mycosis or intertrigo, respectively and every 5 days the patients had been controlled by the physicians with respect to the healing process. The observation period for each patient lasted 15 days. Results: Symptoms of mycoses on patient's hands (6 patients) seem to be improved more rapidly between five and ten days than on feet (18 patients) which lasted about 15 days. In all the patients, the skin damaged by mycosis could be visually restored completely during 15 days. Most intertrigo patients showed a clinically restored skin surface already after 10 days. No adverse health effects were observed for all the patients. Conclusions: The zeolite product Detoxsan® paste is able to restore skin damaged by mycosis and intertrigo. The formulation of the paste assures the adherence of the mineral to the skin and the properties of this zeolite with its excellent binding capacities for histamine and water, and efficiently promotes the healing process.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"41 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75833472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema Multiforme Major Induced by Lysergic Acid Diethylamide","authors":"Sik Yeng Chan, K. Hussain, C. Soon","doi":"10.35248/2155-9554.19.10.509","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.509","url":null,"abstract":"Erythema multiforme major (EMM) is a severe hypersensitivity skin reaction that is potentially life threatening. We present a case report of a gentleman who presented with EMM induced by Lysergic acid diethylamide. The case aims to raise awareness and highlights the importance of taking a comprehensive drug history including recreational drug use. This is especially important in the face of rising recreational drug usage rates.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82496860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypereosinophilia as a Rare Side Effect of Methotrexate in a Patient with Erythrodermic Psoriasis: The First Case Report","authors":"Thanh Thai Van Le, C. T. H. Nguyen, H. Nguyen, Chau Van Tro, G. Tran, Lien Thi Nguyen","doi":"10.35248/2155-9554.19.10.501","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.501","url":null,"abstract":"Methotrexate (MTX) has been approved for the treatment of psoriasis and is considered to be effective and relatively safe. This drug was widely used for treatment of psoriasis in Vietnam for many years. Life-threatening MTX toxicity is rare but may rapidly develop when the drug is administered. In line with the interface dermatitis and a remarked eosinophilic infiltration in the cutaneous lesion, the diagnosis of hypereosinophilia as an adverse reaction in our patient was supported by the dramatic improvement of symptoms and decreased eosinophils after withdrawal of MTX. To the best of our knowledge, this is the first case that showed isolated hypereosinophilia as an adverse reaction of MTX in psoriasis treatment that may challenge in early recognition. Awareness and prompt recognition of this severe adverse reaction can result in life-saving discontinuation of MTX.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88438458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalp White Piedra caused by Trichosporon asahii","authors":"M. Safae, L. Myriam, Senouci Karima, Meziane Mariam","doi":"10.35248/2155-9554.19.10.514","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.514","url":null,"abstract":"A 10-year-old girl presented for asymptomatic whitish particles in the scalp hair since 6 months (Figure 1). It was encircling almost the entirety of the scalp hairs’ shafts, easily detachable and measuring 1 to 1.5 mm.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"18 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73055403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Tolerability of a Tretinoin 0.02%, Clindamycin 0.8% and Glycolic Acid 4% Gel in Acne: A Multicenter, Prospective, Pragmatic, Assessor-Blinded, 12-Week Trial on 159 Subjects","authors":"M. Milani, C. Cortelazzi, P. Chieco, Anna Ferrazzi, N. Gargano, Elisa Maiani, A. Mazzi, M. Mannino, D. Marciani, S. Pastena, Silvia Pugliarello, V. Salamone, T. Sisto, R. Scarselli, C. Solaroli, Gustavo Spano","doi":"10.35248/2155-9554.19.10.503","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.503","url":null,"abstract":"Background: Topical retinoid and antibacterial agents are commonly used as first-line treatments in mild/moderate acne vulgaris (AV). Adherence to retinoid treatment could be limited by the low local tolerability. Literature data show that up to 15% of patients prematurely stop the treatment with retinoids because of skin irritation. A medical device in gel formulation containing tretinoin (0.02%), glycolic acid (4%) and clindamycin (0.8%) is available. So far, no real-life, prospective data regarding efficacy and tolerability of this gel are available. We performed a prospective, multicenter, pragmatic 12-week, assessor-blinded trial. Primary outcomes were the changes of Total acne lesions (TL) count. Secondary outcomes were the evolution of Global Acne Grading System score (GAGS) e and Noninflammatory (NI-L) and Inflammatory (I-L) lesions count. An additional secondary outcome was also to evaluate the local tolerability of the gel. Materials and methods: In a real-life multicenter trial, 159 subjects with mild/moderate AV of the face were enrolled after their informed consent in a 12-week trial. Subjects were instructed to apply the gel once daily at evening. Baseline GAGS score was calculated, and a baseline picture of the face was also taken. Visits were performed after 6 and 12 weeks. Clinical evaluation and pictures were performed at the same time-points. GAGS score, NI-L and I-L calculation were performed evaluating subjects’ pictures coded in a randomized fashion by an assessor unaware of time-sequence. At week 6 and 12, an Investigator Global Assessment (IGA) score, using a 5-point scale was also calculated. Outcomes evaluation was performed on an Intention-to-treat basis. Results: A total of 134 (84%) subjects concluded the 12-week treatment period. Twenty-five subjects (16%) concluded prematurely the trial due to poor local tolerability. At baseline the total number of TL was 17 ± 10. Active treatment reduced significantly TL to 11 ± 7 after 6 weeks and to 6.3 ± 5 after 12 weeks, representing a -63% reduction in comparison with baseline. The mean ± SD GAGS score at baseline was 17.3 ± 8. GAGS score was reduced significantly to 11.8 ± 4 after 6 weeks and to 6.3 ± 3 at the end of treatment (a -63% reduction). Both NI-L and I-L lesions numbers were significant reduced at week 6 (NI-L: -42%; I-L:-35%) and at week 12 (NI-L:-65%; I-L:-65%). Tolerability was evaluated good/very good in 123 out of 134 subjects (91%). Conclusion: This gel containing tretinoin, glycolic and clindamycin, used as monotherapy in the treatment of mild to moderate acne, has shown to be effective in reducing TL, NI-L, I-L and GAGS score. The local tolerability profile is in line with other topical retinoids products.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74973730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser Scanning Confocal Microscopy for Diagnostics of Brunsting-Perry Type Cicatrical Pemphigoid Cases, along with Review of Literature","authors":"Katarzyna Osipowicz, B. Jakubowska, C. Kowalewski, T. Hashimoto, K. Woźniak","doi":"10.4172/2155-9554.1000479","DOIUrl":"https://doi.org/10.4172/2155-9554.1000479","url":null,"abstract":"Background: In the literature there are a few reported cases of cicatrical pemphigoid Brunsting-Perry type (CPBP). CPBP is well clinically characterized by clinical research, however is heterogeneous in a term of immunological findings. Laser scanning confocal microscopy (LSCM) is a helpful tool for diagnostics of cicatricial pemphigoid in general, especially when circulating antibodies are not detectable. Objectives: Application of LSCM for the first time in a case with clinical features of CPBP and review the literature. Methods: Skin biopsy was taken for LSCM studies. LSCM technique relies on comparison between the location of IgG/IgA deposits and basement membrane zone (BMZ) markers: antibodies directed to laminin 332 served as a marker of lower part of lamina lucida, whereas antibodies to type IV collagen served as a marker of lamina densa. Immunoglobulins are labeled with anti-human IgG-FITC (green staining), whereas BMZ markers are labeled with anti-mouse IgG-Cy 5 (red). Both fluorescence are simultaneously excited and overlayed by appropriate laser lines and asseses by computer program. Results: LSCM studies disclosed both IgG and IgA located below laminin-332 and above type IV collagen, characteristic of cicatricial pemphigoid.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"15 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75606197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Child Eczema on Family Members Assessed by 2 Different Quality of Life Assessment Tools","authors":"Alhammadi Ms, Z. Sheikh, Alagöz Ms, D. AlAbadie","doi":"10.4172/2155-9554.1000480","DOIUrl":"https://doi.org/10.4172/2155-9554.1000480","url":null,"abstract":"Introduction: Eczema is a common condition affecting children characterized by itching and inflammation of the skin which can affect the quality of life of the patient and family involved. This study is aimed at assessing the quality of life of family members with children suffering from this condition. Methods and analysis: Two different questionnaires were used for assessment and these are Dermatitis family impact (DFI) and family dermatology life quality index (FDLQI). Twenty-seven parents were involved in the study and data was analyzed using IBM SPSS Statistics software (SPSS Inc, Chicago, IL, USA). The 2 questionnaires were then compared using student’s T-test. Different family units were compared using one-way ANOVA. Conclusion: The mean FDLQI was 19.8 ± 5.4 S’s with a range of 10-30 which is classified as having an extremely large effect on the parent’s life. The mean DFI score was 20.6 ± 5.70 which is also classified as having an extremely large effect on the parent’s life.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"66 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72784261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Autologous Platelet-Rich Plasma alone or in Combination with a Lotion Containing Growth-Factor like Polypeptides and Taurine in the Treatment of Androgenic Alopecia: A Randomized, Prospective, AssessorBlinded Trial","authors":"T. Lazzari, M. Milani","doi":"10.35248/2155-9554.19.10.506","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.506","url":null,"abstract":"Introduction and objectives: Autologous Platelet-Rich Plasma (PRP) dermal injections are considered as a therapeutic option for the medical treatment of androgenic alopecia (AGA). However, clinical efficacy of this approach in some cases could be disappointing. Positive effects of PRP in AGA seem to correlate, at least in part, with a growth factors mimicking action. A hair scalp lotion containing high-purified, growth factors-like polypeptides (octapeptide 2, acetyl decapeptide 3, oligopeptide 20 and copper tripeptide) with the addition of glycine and taurine (GFM-L) is available. So far, no data regarding the potential synergistic effect of autologous PRP treatment combined with GFM-L are available. We therefore conducted a prospective, randomized, assessor-blinded trial to compare the efficacy and tolerability of PRP alone vs. PRP and GFM-L treatment in men and women with AGA. Materials and methods: The study was a prospective, randomized (with a balance ratio of 2:1), assessor-blinded, 3- month trial. Thirty subjects (18 men and 12 women; mean age: 41 years) were enrolled after their written informed consent. Twenty subjects were allocated to PRP treatment cycle followed by GFM-L application for 3 months (2 ml of lotion every other day) (Group A) and 10 subjects were allocated to PRP treatment alone (Group B). In both groups autologous PRP injections on the affected area were performed over a period of 3 months at interval of 3-4 weeks, using a volume of 10 cc of PRP for each session treatment. Primary end point was the Investigator Global Assessment (IGA) score of clinical efficacy at month 3 in comparison with baseline. IGA score ranged from 0 (no improvement) to 3 (strong improvement). Secondary endpoint was the evolution of Hamilton scale grading (HSG), evaluated at baseline and at the end of study period. IGA score and HSG were performed by an investigator unaware of the treatment allocation group. Results: All the enrolled subjects concluded the study period. At baseline HSG was 2.0 ± 0.6 in Group A and 2.1 ± 0.3 in Group B. At month 3, a significant reduction of HSG was observed in Group A subjects only, both in comparison with baseline and in comparison, with Group B values (1.3 ± 0.5 vs. 2.1 ± 0.37; P=0.0028). At month 3, IGA score was 2.1 ± 0.9 in group A and 0.8 ± 0.3 in group B (P=0.0031). GFM-lotion was well tolerated. Conclusion: The combination of GFM-lotion containing growth factors like peptides and taurine with autologous PRP treatment is superior in term of efficacy to the treatment with PRP alone in subjects with AGA.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85508673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}