Pub Date : 2019-01-02DOI: 10.4172/2155-9554-C10-096
Hye-Rim Moon
{"title":"Pigmentation of basal cell carcinoma is inversely associated with tumor aggressiveness in Asian patients","authors":"Hye-Rim Moon","doi":"10.4172/2155-9554-C10-096","DOIUrl":"https://doi.org/10.4172/2155-9554-C10-096","url":null,"abstract":"","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88225626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2155-9554.19.10.512
Sara Mai, S. Baya, S. Maouni, K. Znati, J. Hafidi, A. Abbassi, K. Senouci
A 70-year-old man with no notable medical history presented to our department with a huge tumor on his pubic area that had been evolving for over 20 years causing itching and foul smelling discharge. Physical examination revealed a cauliflower-like voluminous tumor on the patient’s pubis with extension to the penoscrotal area and the lower abdomen (Figure 1).
{"title":"A Giant Buschke-Löwenstein Tumor","authors":"Sara Mai, S. Baya, S. Maouni, K. Znati, J. Hafidi, A. Abbassi, K. Senouci","doi":"10.35248/2155-9554.19.10.512","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.512","url":null,"abstract":"A 70-year-old man with no notable medical history presented to our department with a huge tumor on his pubic area that had been evolving for over 20 years causing itching and foul smelling discharge. Physical examination revealed a cauliflower-like voluminous tumor on the patient’s pubis with extension to the penoscrotal area and the lower abdomen (Figure 1).","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"46 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74018214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2155-9554.1000485
A. Torres, Yamile Sanchez, W. Dathe
Objective: To offer an alternative therapy for the treatment of mycosis and intertrigo by a well investigated natural zeolite mineral embedded in a formulation of petrolatum and squalane. Methods: A total of 43 patients, who were suffering from mycosis and intertrigo in the period started from July 2nd and ended on September 29th in 2018, were treated at the Policlinico Julio Grave de Peralta and dialysis department of the Hospital V. I. Lenin. Among them, 31 patients agreed with the application of the alternative therapy with Detoxsan® paste to overcome these dermatological diseases. The paste was applied semi-daily to the skin damaged by mycosis or intertrigo, respectively and every 5 days the patients had been controlled by the physicians with respect to the healing process. The observation period for each patient lasted 15 days. Results: Symptoms of mycoses on patient's hands (6 patients) seem to be improved more rapidly between five and ten days than on feet (18 patients) which lasted about 15 days. In all the patients, the skin damaged by mycosis could be visually restored completely during 15 days. Most intertrigo patients showed a clinically restored skin surface already after 10 days. No adverse health effects were observed for all the patients. Conclusions: The zeolite product Detoxsan® paste is able to restore skin damaged by mycosis and intertrigo. The formulation of the paste assures the adherence of the mineral to the skin and the properties of this zeolite with its excellent binding capacities for histamine and water, and efficiently promotes the healing process.
目的:用一种经充分研究的天然沸石矿物包埋在凡脱油和角鲨烷的配方中，为治疗真菌病和三合症提供一种替代疗法。方法:从2018年7月2日至9月29日，在列宁医院Julio Grave de Peralta polilinico和透析科治疗的43例霉菌病和室内病患者。其中，31例患者同意应用解毒san®膏剂替代疗法来克服这些皮肤病。膏体每日半次涂抹在霉菌病或三节间症损伤的皮肤上，每5天由医生对患者的愈合过程进行控制。每例患者的观察期为15 d。结果:手部真菌病(6例)症状在5 ~ 10天内比足部真菌病(18例)改善更快，足部真菌病持续约15天。所有患者均能在15天内视觉上完全恢复皮肤损伤。大多数三角间症患者在10天后已表现出临床恢复的皮肤表面。所有患者均未观察到不良健康影响。结论:沸石产品解毒石®膏体具有修复霉菌病和皮肤夹层损伤的作用。膏体的配方保证了矿物质对皮肤的粘附性，以及沸石对组胺和水的优异结合能力，并有效地促进愈合过程。
{"title":"Detoxsan® Paste Formulation Containing Zeolites for the Treatment of Mycosis and Intertrigo Carried Out Under Climatic Conditions of Cuba","authors":"A. Torres, Yamile Sanchez, W. Dathe","doi":"10.4172/2155-9554.1000485","DOIUrl":"https://doi.org/10.4172/2155-9554.1000485","url":null,"abstract":"Objective: To offer an alternative therapy for the treatment of mycosis and intertrigo by a well investigated natural zeolite mineral embedded in a formulation of petrolatum and squalane. Methods: A total of 43 patients, who were suffering from mycosis and intertrigo in the period started from July 2nd and ended on September 29th in 2018, were treated at the Policlinico Julio Grave de Peralta and dialysis department of the Hospital V. I. Lenin. Among them, 31 patients agreed with the application of the alternative therapy with Detoxsan® paste to overcome these dermatological diseases. The paste was applied semi-daily to the skin damaged by mycosis or intertrigo, respectively and every 5 days the patients had been controlled by the physicians with respect to the healing process. The observation period for each patient lasted 15 days. Results: Symptoms of mycoses on patient's hands (6 patients) seem to be improved more rapidly between five and ten days than on feet (18 patients) which lasted about 15 days. In all the patients, the skin damaged by mycosis could be visually restored completely during 15 days. Most intertrigo patients showed a clinically restored skin surface already after 10 days. No adverse health effects were observed for all the patients. Conclusions: The zeolite product Detoxsan® paste is able to restore skin damaged by mycosis and intertrigo. The formulation of the paste assures the adherence of the mineral to the skin and the properties of this zeolite with its excellent binding capacities for histamine and water, and efficiently promotes the healing process.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"41 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75833472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2155-9554.19.10.509
Sik Yeng Chan, K. Hussain, C. Soon
Erythema multiforme major (EMM) is a severe hypersensitivity skin reaction that is potentially life threatening. We present a case report of a gentleman who presented with EMM induced by Lysergic acid diethylamide. The case aims to raise awareness and highlights the importance of taking a comprehensive drug history including recreational drug use. This is especially important in the face of rising recreational drug usage rates.
{"title":"Erythema Multiforme Major Induced by Lysergic Acid Diethylamide","authors":"Sik Yeng Chan, K. Hussain, C. Soon","doi":"10.35248/2155-9554.19.10.509","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.509","url":null,"abstract":"Erythema multiforme major (EMM) is a severe hypersensitivity skin reaction that is potentially life threatening. We present a case report of a gentleman who presented with EMM induced by Lysergic acid diethylamide. The case aims to raise awareness and highlights the importance of taking a comprehensive drug history including recreational drug use. This is especially important in the face of rising recreational drug usage rates.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82496860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2155-9554.19.10.501
Thanh Thai Van Le, C. T. H. Nguyen, H. Nguyen, Chau Van Tro, G. Tran, Lien Thi Nguyen
Methotrexate (MTX) has been approved for the treatment of psoriasis and is considered to be effective and relatively safe. This drug was widely used for treatment of psoriasis in Vietnam for many years. Life-threatening MTX toxicity is rare but may rapidly develop when the drug is administered. In line with the interface dermatitis and a remarked eosinophilic infiltration in the cutaneous lesion, the diagnosis of hypereosinophilia as an adverse reaction in our patient was supported by the dramatic improvement of symptoms and decreased eosinophils after withdrawal of MTX. To the best of our knowledge, this is the first case that showed isolated hypereosinophilia as an adverse reaction of MTX in psoriasis treatment that may challenge in early recognition. Awareness and prompt recognition of this severe adverse reaction can result in life-saving discontinuation of MTX.
{"title":"Hypereosinophilia as a Rare Side Effect of Methotrexate in a Patient with Erythrodermic Psoriasis: The First Case Report","authors":"Thanh Thai Van Le, C. T. H. Nguyen, H. Nguyen, Chau Van Tro, G. Tran, Lien Thi Nguyen","doi":"10.35248/2155-9554.19.10.501","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.501","url":null,"abstract":"Methotrexate (MTX) has been approved for the treatment of psoriasis and is considered to be effective and relatively safe. This drug was widely used for treatment of psoriasis in Vietnam for many years. Life-threatening MTX toxicity is rare but may rapidly develop when the drug is administered. In line with the interface dermatitis and a remarked eosinophilic infiltration in the cutaneous lesion, the diagnosis of hypereosinophilia as an adverse reaction in our patient was supported by the dramatic improvement of symptoms and decreased eosinophils after withdrawal of MTX. To the best of our knowledge, this is the first case that showed isolated hypereosinophilia as an adverse reaction of MTX in psoriasis treatment that may challenge in early recognition. Awareness and prompt recognition of this severe adverse reaction can result in life-saving discontinuation of MTX.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88438458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2155-9554.19.10.514
M. Safae, L. Myriam, Senouci Karima, Meziane Mariam
A 10-year-old girl presented for asymptomatic whitish particles in the scalp hair since 6 months (Figure 1). It was encircling almost the entirety of the scalp hairs’ shafts, easily detachable and measuring 1 to 1.5 mm.
{"title":"Scalp White Piedra caused by Trichosporon asahii","authors":"M. Safae, L. Myriam, Senouci Karima, Meziane Mariam","doi":"10.35248/2155-9554.19.10.514","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.514","url":null,"abstract":"A 10-year-old girl presented for asymptomatic whitish particles in the scalp hair since 6 months (Figure 1). It was encircling almost the entirety of the scalp hairs’ shafts, easily detachable and measuring 1 to 1.5 mm.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"18 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73055403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2155-9554.19.10.503
M. Milani, C. Cortelazzi, P. Chieco, Anna Ferrazzi, N. Gargano, Elisa Maiani, A. Mazzi, M. Mannino, D. Marciani, S. Pastena, Silvia Pugliarello, V. Salamone, T. Sisto, R. Scarselli, C. Solaroli, Gustavo Spano
Background: Topical retinoid and antibacterial agents are commonly used as first-line treatments in mild/moderate acne vulgaris (AV). Adherence to retinoid treatment could be limited by the low local tolerability. Literature data show that up to 15% of patients prematurely stop the treatment with retinoids because of skin irritation. A medical device in gel formulation containing tretinoin (0.02%), glycolic acid (4%) and clindamycin (0.8%) is available. So far, no real-life, prospective data regarding efficacy and tolerability of this gel are available. We performed a prospective, multicenter, pragmatic 12-week, assessor-blinded trial. Primary outcomes were the changes of Total acne lesions (TL) count. Secondary outcomes were the evolution of Global Acne Grading System score (GAGS) e and Noninflammatory (NI-L) and Inflammatory (I-L) lesions count. An additional secondary outcome was also to evaluate the local tolerability of the gel. Materials and methods: In a real-life multicenter trial, 159 subjects with mild/moderate AV of the face were enrolled after their informed consent in a 12-week trial. Subjects were instructed to apply the gel once daily at evening. Baseline GAGS score was calculated, and a baseline picture of the face was also taken. Visits were performed after 6 and 12 weeks. Clinical evaluation and pictures were performed at the same time-points. GAGS score, NI-L and I-L calculation were performed evaluating subjects’ pictures coded in a randomized fashion by an assessor unaware of time-sequence. At week 6 and 12, an Investigator Global Assessment (IGA) score, using a 5-point scale was also calculated. Outcomes evaluation was performed on an Intention-to-treat basis. Results: A total of 134 (84%) subjects concluded the 12-week treatment period. Twenty-five subjects (16%) concluded prematurely the trial due to poor local tolerability. At baseline the total number of TL was 17 ± 10. Active treatment reduced significantly TL to 11 ± 7 after 6 weeks and to 6.3 ± 5 after 12 weeks, representing a -63% reduction in comparison with baseline. The mean ± SD GAGS score at baseline was 17.3 ± 8. GAGS score was reduced significantly to 11.8 ± 4 after 6 weeks and to 6.3 ± 3 at the end of treatment (a -63% reduction). Both NI-L and I-L lesions numbers were significant reduced at week 6 (NI-L: -42%; I-L:-35%) and at week 12 (NI-L:-65%; I-L:-65%). Tolerability was evaluated good/very good in 123 out of 134 subjects (91%). Conclusion: This gel containing tretinoin, glycolic and clindamycin, used as monotherapy in the treatment of mild to moderate acne, has shown to be effective in reducing TL, NI-L, I-L and GAGS score. The local tolerability profile is in line with other topical retinoids products.
{"title":"Efficacy and Tolerability of a Tretinoin 0.02%, Clindamycin 0.8% and Glycolic Acid 4% Gel in Acne: A Multicenter, Prospective, Pragmatic, Assessor-Blinded, 12-Week Trial on 159 Subjects","authors":"M. Milani, C. Cortelazzi, P. Chieco, Anna Ferrazzi, N. Gargano, Elisa Maiani, A. Mazzi, M. Mannino, D. Marciani, S. Pastena, Silvia Pugliarello, V. Salamone, T. Sisto, R. Scarselli, C. Solaroli, Gustavo Spano","doi":"10.35248/2155-9554.19.10.503","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.503","url":null,"abstract":"Background: Topical retinoid and antibacterial agents are commonly used as first-line treatments in mild/moderate acne vulgaris (AV). Adherence to retinoid treatment could be limited by the low local tolerability. Literature data show that up to 15% of patients prematurely stop the treatment with retinoids because of skin irritation. A medical device in gel formulation containing tretinoin (0.02%), glycolic acid (4%) and clindamycin (0.8%) is available. So far, no real-life, prospective data regarding efficacy and tolerability of this gel are available. We performed a prospective, multicenter, pragmatic 12-week, assessor-blinded trial. Primary outcomes were the changes of Total acne lesions (TL) count. Secondary outcomes were the evolution of Global Acne Grading System score (GAGS) e and Noninflammatory (NI-L) and Inflammatory (I-L) lesions count. An additional secondary outcome was also to evaluate the local tolerability of the gel. Materials and methods: In a real-life multicenter trial, 159 subjects with mild/moderate AV of the face were enrolled after their informed consent in a 12-week trial. Subjects were instructed to apply the gel once daily at evening. Baseline GAGS score was calculated, and a baseline picture of the face was also taken. Visits were performed after 6 and 12 weeks. Clinical evaluation and pictures were performed at the same time-points. GAGS score, NI-L and I-L calculation were performed evaluating subjects’ pictures coded in a randomized fashion by an assessor unaware of time-sequence. At week 6 and 12, an Investigator Global Assessment (IGA) score, using a 5-point scale was also calculated. Outcomes evaluation was performed on an Intention-to-treat basis. Results: A total of 134 (84%) subjects concluded the 12-week treatment period. Twenty-five subjects (16%) concluded prematurely the trial due to poor local tolerability. At baseline the total number of TL was 17 ± 10. Active treatment reduced significantly TL to 11 ± 7 after 6 weeks and to 6.3 ± 5 after 12 weeks, representing a -63% reduction in comparison with baseline. The mean ± SD GAGS score at baseline was 17.3 ± 8. GAGS score was reduced significantly to 11.8 ± 4 after 6 weeks and to 6.3 ± 3 at the end of treatment (a -63% reduction). Both NI-L and I-L lesions numbers were significant reduced at week 6 (NI-L: -42%; I-L:-35%) and at week 12 (NI-L:-65%; I-L:-65%). Tolerability was evaluated good/very good in 123 out of 134 subjects (91%). Conclusion: This gel containing tretinoin, glycolic and clindamycin, used as monotherapy in the treatment of mild to moderate acne, has shown to be effective in reducing TL, NI-L, I-L and GAGS score. The local tolerability profile is in line with other topical retinoids products.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74973730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2155-9554.1000479
Katarzyna Osipowicz, B. Jakubowska, C. Kowalewski, T. Hashimoto, K. Woźniak
Background: In the literature there are a few reported cases of cicatrical pemphigoid Brunsting-Perry type (CPBP). CPBP is well clinically characterized by clinical research, however is heterogeneous in a term of immunological findings. Laser scanning confocal microscopy (LSCM) is a helpful tool for diagnostics of cicatricial pemphigoid in general, especially when circulating antibodies are not detectable. Objectives: Application of LSCM for the first time in a case with clinical features of CPBP and review the literature. Methods: Skin biopsy was taken for LSCM studies. LSCM technique relies on comparison between the location of IgG/IgA deposits and basement membrane zone (BMZ) markers: antibodies directed to laminin 332 served as a marker of lower part of lamina lucida, whereas antibodies to type IV collagen served as a marker of lamina densa. Immunoglobulins are labeled with anti-human IgG-FITC (green staining), whereas BMZ markers are labeled with anti-mouse IgG-Cy 5 (red). Both fluorescence are simultaneously excited and overlayed by appropriate laser lines and asseses by computer program. Results: LSCM studies disclosed both IgG and IgA located below laminin-332 and above type IV collagen, characteristic of cicatricial pemphigoid.
{"title":"Laser Scanning Confocal Microscopy for Diagnostics of Brunsting-Perry Type Cicatrical Pemphigoid Cases, along with Review of Literature","authors":"Katarzyna Osipowicz, B. Jakubowska, C. Kowalewski, T. Hashimoto, K. Woźniak","doi":"10.4172/2155-9554.1000479","DOIUrl":"https://doi.org/10.4172/2155-9554.1000479","url":null,"abstract":"Background: In the literature there are a few reported cases of cicatrical pemphigoid Brunsting-Perry type (CPBP). CPBP is well clinically characterized by clinical research, however is heterogeneous in a term of immunological findings. Laser scanning confocal microscopy (LSCM) is a helpful tool for diagnostics of cicatricial pemphigoid in general, especially when circulating antibodies are not detectable. Objectives: Application of LSCM for the first time in a case with clinical features of CPBP and review the literature. Methods: Skin biopsy was taken for LSCM studies. LSCM technique relies on comparison between the location of IgG/IgA deposits and basement membrane zone (BMZ) markers: antibodies directed to laminin 332 served as a marker of lower part of lamina lucida, whereas antibodies to type IV collagen served as a marker of lamina densa. Immunoglobulins are labeled with anti-human IgG-FITC (green staining), whereas BMZ markers are labeled with anti-mouse IgG-Cy 5 (red). Both fluorescence are simultaneously excited and overlayed by appropriate laser lines and asseses by computer program. Results: LSCM studies disclosed both IgG and IgA located below laminin-332 and above type IV collagen, characteristic of cicatricial pemphigoid.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"15 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75606197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2155-9554.1000480
Alhammadi Ms, Z. Sheikh, Alagöz Ms, D. AlAbadie
Introduction: Eczema is a common condition affecting children characterized by itching and inflammation of the skin which can affect the quality of life of the patient and family involved. This study is aimed at assessing the quality of life of family members with children suffering from this condition. Methods and analysis: Two different questionnaires were used for assessment and these are Dermatitis family impact (DFI) and family dermatology life quality index (FDLQI). Twenty-seven parents were involved in the study and data was analyzed using IBM SPSS Statistics software (SPSS Inc, Chicago, IL, USA). The 2 questionnaires were then compared using student’s T-test. Different family units were compared using one-way ANOVA. Conclusion: The mean FDLQI was 19.8 ± 5.4 S’s with a range of 10-30 which is classified as having an extremely large effect on the parent’s life. The mean DFI score was 20.6 ± 5.70 which is also classified as having an extremely large effect on the parent’s life.
简介:湿疹是一种影响儿童的常见疾病，其特征是皮肤瘙痒和炎症，可影响患者及其家人的生活质量。本研究旨在评估患有这种疾病的儿童的家庭成员的生活质量。方法与分析:采用皮炎家庭影响(DFI)和家庭皮肤病生活质量指数(FDLQI)两种不同的问卷进行评估。27名家长参与了这项研究，使用IBM SPSS统计软件(SPSS Inc .， Chicago, IL, USA)对数据进行分析。然后用学生t检验对两份问卷进行比较。不同家庭单位采用单因素方差分析进行比较。结论:FDLQI平均值为19.8±5.4 S，范围为10 ~ 30，对父母生活影响极大。DFI平均得分为20.6±5.70，也被归类为对父母生活有极大影响。
{"title":"The Impact of Child Eczema on Family Members Assessed by 2 Different Quality of Life Assessment Tools","authors":"Alhammadi Ms, Z. Sheikh, Alagöz Ms, D. AlAbadie","doi":"10.4172/2155-9554.1000480","DOIUrl":"https://doi.org/10.4172/2155-9554.1000480","url":null,"abstract":"Introduction: Eczema is a common condition affecting children characterized by itching and inflammation of the skin which can affect the quality of life of the patient and family involved. This study is aimed at assessing the quality of life of family members with children suffering from this condition. Methods and analysis: Two different questionnaires were used for assessment and these are Dermatitis family impact (DFI) and family dermatology life quality index (FDLQI). Twenty-seven parents were involved in the study and data was analyzed using IBM SPSS Statistics software (SPSS Inc, Chicago, IL, USA). The 2 questionnaires were then compared using student’s T-test. Different family units were compared using one-way ANOVA. Conclusion: The mean FDLQI was 19.8 ± 5.4 S’s with a range of 10-30 which is classified as having an extremely large effect on the parent’s life. The mean DFI score was 20.6 ± 5.70 which is also classified as having an extremely large effect on the parent’s life.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"66 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72784261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/2155-9554.19.10.508
I. Ginsburg, Erez Koren
The aim of the present short communication is to shed a novel light on the auto immune disorder atopic dermatitis by discussing the possible role played by the plethora of toxic agents released by Staphylococcus aureus which can act in a tight synergism with neutrophils derived cationic polyelectrolytes as related to the pathogenesis of atopic dermatitis (AD). This disorder results in inflammation of the skin characterized by itchiness, red skin, a rash, by the accumulations of large numbers of Staphylococcus aureus their toxins and proinflammatory agents secreted by migrating neutrophiles are considered the main cause of AD pathogenicity.
{"title":"A Novel Approach That May Explain the Role of Staphylococcus aureus, Polycations, Neutrophils Pro-Inflammatory Agonists and the Bacteriolysis and Auto Immune Phenomena as Possible Major Events in the Pathogenesis of Atopic Dermatitis: A Working Hypothesis","authors":"I. Ginsburg, Erez Koren","doi":"10.35248/2155-9554.19.10.508","DOIUrl":"https://doi.org/10.35248/2155-9554.19.10.508","url":null,"abstract":"The aim of the present short communication is to shed a novel light on the auto immune disorder atopic dermatitis by discussing the possible role played by the plethora of toxic agents released by Staphylococcus aureus which can act in a tight synergism with neutrophils derived cationic polyelectrolytes as related to the pathogenesis of atopic dermatitis (AD). This disorder results in inflammation of the skin characterized by itchiness, red skin, a rash, by the accumulations of large numbers of Staphylococcus aureus their toxins and proinflammatory agents secreted by migrating neutrophiles are considered the main cause of AD pathogenicity.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"11 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82918580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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