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Acne-Related Conditions and Sensitive Skin Syndrome 痤疮相关疾病和敏感皮肤综合征
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.12.E117
C. Michael
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引用次数: 0
COVID-19 and Impact on Dermatology COVID-19及其对皮肤病学的影响
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.12.E115
L. Martini
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引用次数: 0
Retrospective Analysis of a Single- Kuwaiti Center Clinical Experience Toward Development of Proper Controlling Treatment of 84 Pemphigus Patients with a Long-Term Follow-Up: Efficacy and Safety of the Multidrug Protocol Combining Intravenous Immunoglobulin with the Cytotoxic Immunosuppressor Drugs 回顾性分析科威特中心对84例天疱疮患者进行长期随访的临床经验:静脉注射免疫球蛋白联合细胞毒性免疫抑制药物的多药方案的有效性和安全性
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.12.567
I. Almasry, V. Lazarević, F. Alkhawaja, Jihan M Rajy, N. Musami, Nadia Alnaki, R. Dvořák, Aliaa Sadek, Humoud Al Sabah, Atlal Al-Lafi
Pemphigus is the name of a group of autoimmune pathological entities characterized by the formation of intraepithelial blisters in the skin and/or mucosa. Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF) are considered as classical forms. Rare, non-classical forms of Pemphigus include: Pemphigus herpetiformis, IgA pemphigus, Paraneoplastic pemphigus, IgG/IgA pemphigus. Aim: Aim of our study is to explore the prognostic influence of clinical, immunological and therapeutic drugs on disease course and remission in different pemphigus variants in Kuwait and to establish a safe and effective multidrug protocol. Plan of the study is to make a correlation between epidemiological factors, therapy used and clinical and immunological remission, as well as, follow up of comorbidities in our patients. 84 patients were evaluated, from 1st January 1990 to 31st December 2013. IVIG is used as a third-line adjuvant treatment initially flanked by high-dose systemic corticosteroids and steroid- sparing immune-suppressants. Thus, this multidrug IVIG regimen made it possible to achieve a rapid control of the pemphigus symptoms, with progression to a stable disease remission, while maintenance an overall safety of treatment.
天疱疮是一组自身免疫性病理实体的名称,其特征是皮肤和/或粘膜上皮内水疱的形成。寻常型天疱疮(PV)和叶状天疱疮(PF)被认为是经典形式。罕见的,非经典形式的天疱疮包括:疱疹样天疱疮,IgA天疱疮,副肿瘤天疱疮,IgG/IgA天疱疮。目的:探讨临床、免疫和治疗药物对科威特不同类型天疱疮病程和缓解的预后影响,并建立安全有效的多药治疗方案。本研究的目的是研究流行病学因素、所采用的治疗方法与临床和免疫缓解的相关性,并对患者的合并症进行随访。从1990年1月1日至2013年12月31日对84例患者进行了评估。IVIG最初被用作三线辅助治疗,与大剂量全身皮质类固醇和保留类固醇的免疫抑制剂同时使用。因此,这种多药IVIG方案可以实现天疱疮症状的快速控制,并进展到稳定的疾病缓解,同时保持治疗的总体安全性。
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引用次数: 0
Psychological Impact of Alopecia Areata on Egyptian Patients 斑秃对埃及患者的心理影响
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.12.568
Doaa A. E. Abou-Taleb, Omnia H Abd El Hameed, Alaa Ea Moubasher
Alopecia occupies an important place in psychiatric comorbidity and may be associated with anxiety, stress and depression. Psychiatric problems are more common in patients with alopecia than in healthy individuals. This study aimed to assess the psychological impact of Alopecia Areata (AA) among Egyptian patients by using the Arabic version of the Depression, Anxiety and Stress Scale (DASS-42). Patients and methods: A total of 100 Egyptian patients with AA were randomly recruited from the outpatient clinics of the department of dermatology of Assiut University Hospital (AUH). The SALT score used to assess the severity of AA. Patients were asked to describe the impact of AA on their life by filling in the Arabic version of DASS-42. Results: 71% of the AA patients were males and 29% were females, 93% were educated either higher education 46% or lower education 47%. The patients of AA who had depression were 90 patients (26% with extreme depression, 22% with severe depression, 29% with moderate depression and 13% with mild depression). Also, anxiety was present in 85% of patients (38% with extreme anxiety, 24% with severe anxiety, 18% with moderate anxiety and 5% with mild anxiety). Regarding stress, it was present in 95% of patients (35% with extreme stress, 23% with severe stress, 32% with moderate stress and 5% with mild stress). Conclusion: Our study may serve as a stimulus to dermatologists to improve the relationships with their patients and re-evaluate their management of AA and put in consideration the psychological management that can help to improve the clinical outcomes in Egyptian patients with AA.
脱发在精神共病中占有重要地位,可能与焦虑、压力和抑郁有关。精神问题在脱发患者中比健康人更常见。本研究旨在通过阿拉伯版抑郁、焦虑和压力量表(DASS-42)评估斑秃(AA)对埃及患者的心理影响。患者和方法:从阿西尤特大学医院(AUH)皮肤科门诊随机招募100例埃及AA患者。SALT评分用于评估AA的严重程度。患者被要求通过填写阿拉伯语版的das -42来描述AA对他们生活的影响。结果:AA患者中男性占71%,女性占29%,高学历占93%,低学历占47%。AA患者中合并抑郁者90例,其中重度抑郁占26%,重度抑郁占22%,中度抑郁占29%,轻度抑郁占13%。此外,85%的患者存在焦虑(38%为极度焦虑,24%为严重焦虑,18%为中度焦虑,5%为轻度焦虑)。关于压力,95%的患者存在压力(35%为极端压力,23%为严重压力,32%为中度压力,5%为轻度压力)。结论:本研究可刺激皮肤科医师改善与患者的关系,重新评估其对AA的处理,并考虑心理管理,有助于改善埃及AA患者的临床结果。
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引用次数: 1
The Recovery of Skin Cancer Services Following the COVID-19 Pandemic, Using Combined Speciality Clinics to Decrease Waiting Times and Improve Cost Efficiency 2019冠状病毒病大流行后恢复皮肤癌服务,利用联合专科诊所减少等待时间并提高成本效率
Pub Date : 2021-01-01 DOI: 10.46889/jdr.2021.2304
C. Brennan, M. Stone, R. Pinder, A. Gowda
The unprecedented COVID-19 pandemic continues to have significant ramifications for nonurgent medical treatment and cancer care globally. Provision of healthcare for noncommunicable disease has been dramatically curtailed across the world, in order to redirect resources in a bid to gain control of the coronavirus. There are multiple reports internationally of significant reductions in urgent cancer referrals [1-4]. In England, patients diagnosed with a stage I primary fell for all types of cancer in the first 4 months of the pandemic compared to pre-pandemic levels (March to June 2019 vs 2020; 18400 vs 12400), equating to a drop of approximately 1500 people per month [5]. Skin cancer primaries are amongst the most impacted1, as by September 2020 the estimated number of malignant cancer diagnoses had reached 95% of pre-pandemic activity in all groups except non-melanoma skin cancer [5]. A Canadian study examined the pandemic’s influence on skin biopsies and demonstrated a precipitous drop to just 15% of expected biopsy numbers compared to the same period in the year prior to the pandemic [4]. Furthermore, the elderly, females and patients living in areas of greater socioeconomic deprivation were disproportionately affected and less likely to attend for skin biopsies when suspicion of cutaneous malignancy was present [4]. Whilst substantial improvements in biopsy rates have been noted, it is expected that a large backlog of cases will
前所未有的COVID-19大流行继续对全球非紧急医疗和癌症护理产生重大影响。为了重新分配资源以控制冠状病毒,世界各地大幅削减了非传染性疾病的医疗保健服务。国际上有多篇关于紧急癌症转诊显著减少的报道[1-4]。在英国,与大流行前的水平相比,在大流行的头4个月,被诊断为I期原发性癌症的患者患各种类型的癌症的比例下降(2019年3月至6月vs 2020年;18400 vs 12400),相当于每月减少约1500人[5]。原发性皮肤癌是受影响最大的1,截至2020年9月,除非黑色素瘤皮肤癌外,所有组中恶性癌症诊断的估计数量已达到大流行前活动的95%[5]。加拿大的一项研究调查了大流行对皮肤活检的影响,结果显示,与大流行前一年同期相比,预期活检数量急剧下降至仅15%[4]。此外,老年人、女性和生活在更严重的社会经济剥夺地区的患者受到不成比例的影响,当怀疑存在皮肤恶性肿瘤时,他们不太可能参加皮肤活检[4]。虽然已经注意到活检率有了实质性的改善,但预计会有大量积压的病例
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引用次数: 0
A Case of Pseudochromohidrosis Cured with Oral Erythromycin and Topical Clindamycin 口服红霉素加外用克林霉素治疗假性色汗1例
Pub Date : 2021-01-01 DOI: 10.46889/jdr.2021.2205
Rashmi Singh
Apocrine chromohidrosis and eccrine pseudochromohidrosis are both rare skin presentations. In case of former patient presents with coloured sweats in apocrine distributions usually axilla, breast etc., while later presents with coloured sweat in eccrine distribution. Such cases need to be reported after other possibilities with similar presentations have been ruled, and need special mention in literature as mostly they are misdiagnosed as factitious. Hereby, I am also reporting one such case of pseudochromohidrosis which needed attention as it was causing anxiety to both patient and family members and its proper diagnosis and treatment brought a great relief to them.
大汗腺色汗症和小汗腺假性色汗症都是罕见的皮肤表现。前者患者在大汗液分布(通常为腋窝、乳房等)出现色汗,而后者在汗液分布中出现色汗。此类病例需要在其他具有类似表现的可能性被排除后报告,并且在文献中需要特别提及,因为大多数病例被误诊为人为。在此,我也报告了一例这样的假性色汗症,它给患者和家属都带来了焦虑,需要引起注意,正确的诊断和治疗给他们带来了很大的缓解。
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引用次数: 0
The Impact of COVID-19 on Outcomes in Aesthetic Medicine: AMulticentre Retrospective Study of Italian Patients COVID-19对美容医学结果的影响:意大利患者的多中心回顾性研究
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.12.553
Maurizio Cavalllini, P. Cirillo, S. Fundarò, G. Muti, A. Santorelli, G. Salti
COVID-19 has profoundly affected the delivery of aesthetic treatment to the general public. In our cohort of patients who underwent botulinum toxin, soft tissue filler infiltration, and thread lifting using bioabsorbable suspension threads from January to April 2020, there was no observed increase in the number of complications. Although cutaneous complications were seen in some botulinum toxin and soft tissue filler injection recipients, the observed complication rates were similar to pre-pandemic figures. Also, these were relatively mild and were easily reversible with supportive therapy. Patients who underwent suspension thread placement did not have apparent complications regardless of having had systemic symptoms attributable to COVID-19. Regardless of the rapid upsurge of the number of cases from February to March, the reported incidences of cutaneous manifestations of possible complications remained low.
2019冠状病毒病深刻影响了向公众提供美容治疗。在2020年1月至4月期间接受肉毒杆菌毒素、软组织填充物浸润和使用生物可吸收悬浮线提线的患者队列中,未观察到并发症数量的增加。虽然在一些肉毒杆菌毒素和软组织填充物注射接受者中发现皮肤并发症,但观察到的并发症发生率与大流行前的数字相似。此外,这些症状相对较轻,在支持治疗下很容易逆转。无论患者是否出现可归因于COVID-19的全身症状,接受悬吊线放置的患者均未出现明显并发症。尽管2月至3月病例数迅速上升,但报告的皮肤表现和可能的并发症发生率仍然很低。
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引用次数: 0
Cosmetic Dermatology Training Exposure among Saudi Residents: A Cross Sectional Study 沙特居民接受美容皮肤科培训:一项横断面研究
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.S8.548
Mohammed H. Abduljabbar
Background: For more than half a century, cosmetic dermatology has been an integral part of dermatology practice. Dermatologists perform more cosmetic procedures than any other specialty on the basis of data from the Center for Medicare and Medicaid Services. Therefore; it is essential that young dermatologists be educated about cosmetic procedures and achieve competency and proficiency in this area, to provide competent care. Aim of the study: This study aimed to assess the current state of cosmetic dermatology training in residency programs. Objectives: To assess the educational exposure of dermatology residents to cosmetic dermatology, to elicit their perceptions on the effect of various teaching strategies for developing procedural skills during their residency in SCFHS-accredited programs in Saudi Arabia, focusing on the residents experience and perspective. Methods: An analytic cross-sectional study was performed on Saudi Dermatology residents in Saudi Arabia at 2019. Permission was taken from Champlain et al. to use the questionnaire. An anonymous self-administrated questionnaire was used which included two parts: the first part inquired about demographic information and the second part inquired about cosmetic dermatology training during residency. Data were analyzed using the Statistical Package for Social Sciences version 20. Results: Thirty six dermatology residents participated in this study with mean age (27.6 ± 1.9), 61.1% were female, 33.3% were in the 4th year and 22.2% were in the first year. Nearly 55.5% of the participants, their residency program were with more than 15 residents. 86% of them had formal lectures including laser, filler, sclerotherapy and chemical peels while 63% were only observer during different cosmetic procedures. Residents in the cosmetic dermatology program prefer more hands-on training (61%) versus lectures (25%) or assigned readings (11%). Conclusion: The residency training program in Saudi Arabia like many programs that provide hands-on cosmetic dermatologic training but there is still lack in the level of participation as a primary surgeon which needs more facilities in both devices and procedures.
背景:半个多世纪以来,美容皮肤科一直是皮肤科实践的一个组成部分。根据医疗保险和医疗补助服务中心的数据,皮肤科医生比其他任何专业进行更多的美容手术。因此;年轻的皮肤科医生必须接受有关美容程序的教育,并在这一领域取得能力和熟练程度,以提供合格的护理。研究目的:本研究旨在评估皮肤科美容住院医师培训的现状。目的:评估皮肤科住院医师接受美容皮肤科教育的情况,了解他们在沙特阿拉伯scfhs认证的住院医师项目中,对各种教学策略对培养程序技能的影响的看法,重点关注住院医师的经验和观点。方法:对2019年在沙特阿拉伯居住的沙特皮肤病居民进行分析性横断面研究。经Champlain等人允许使用该问卷。采用匿名自填问卷,包括两部分:第一部分调查人口学信息,第二部分调查住院医师美容皮肤科培训情况。使用社会科学统计软件包第20版分析数据。结果:36名皮肤科住院医师参与本研究,平均年龄(27.6±1.9)岁,其中女性占61.1%,第4年占33.3%,第1年占22.2%。近55.5%的参与者,他们的住院医师项目有超过15名住院医师。86%的人接受了包括激光、填充、硬化疗法和化学换肤在内的正式讲座,而63%的人在不同的美容过程中只是旁观者。与授课(25%)或指定阅读(11%)相比,美容皮肤科项目的住院医师更喜欢实际操作培训(61%)。结论:沙特阿拉伯的住院医师培训项目与许多提供皮肤美容实践培训的项目一样,但仍缺乏初级外科医生的参与水平,这需要更多的设备和程序设施。
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引用次数: 1
Regulatory Role Played by the mRNA Binding Protein Tristetraprolin in the Skin and its Involvement in Different Diseases mRNA结合蛋白三戊三醇在皮肤中的调节作用及其在不同疾病中的作用
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.S10.574
R. Lotti, T. Zanocco-Marani
The mRNA binding protein Tristetraprolin (TTP), encoded by the ZFP36 gene, plays a fundamental regulatory role in a wide variety of cellular processes by means of its widespread expression in different tissues, and of its ability to post transcriptionally regulate the stability, and therefore the expression, of multiple specific target mRNAs. Because of these features, TTP expression and activity are strictly regulated, and malfunctions of such mechanisms underlie different pathologies. Here we recapitulate the role of TTP in the skin, and its involvement in different conditions, with special reference to psoriasis and cancer.
由ZFP36基因编码的mRNA结合蛋白tristetrprolin (TTP)通过其在不同组织中的广泛表达,以及其转录后调节多种特异性靶mRNA的稳定性和表达的能力,在多种细胞过程中起着重要的调节作用。由于这些特征,TTP的表达和活性受到严格调控,这些机制的故障是不同病理的基础。在这里,我们概述了TTP在皮肤中的作用,以及它在不同情况下的参与,特别涉及牛皮癣和癌症。
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引用次数: 0
Reharmonize: Aesthetic Modalities Founded on the Concepts of Restoring, Reshaping, and Resurfacing for the Comprehensive Treatment of Millennials 重新协调:为千禧一代的综合治疗建立在修复,重塑和重新表面概念上的美学模式
Pub Date : 2021-01-01 DOI: 10.35248/2155-9554.21.12.562
V. Wong, Dennis Malvin Hern, ez Malgapo
Background: Non-surgical minimally invasive procedures, typically in combination, are now becoming the norm. The integrated use of these modalities can be offered to millennial patients, who have unique demands and aesthetic goals. Objective: We aimed to demonstrate the effects of Definisse™ Fillers, Definisse™ Threads and Definisse™ Peel Program in combination to treat two millennials, one female and one male. Case description: The male subject had noticeable change in his facial proportions with correction of hollows over the malar and suborbital areas and a more prominent chin with the help of both Definisse™ Fillers and Definisse™ Threads (double needle and free floating). There was also noticeable improvement in the pigmentation with a more even and clearer skin tone after Definisse™ Lightening Peel application. The patient verbalized a high level of satisfaction with the effects of the treatment overall. The female subject had a noticeable correction of the prominence on her nasal bridge. There was a slightly pronounced lateral and upward lifting of the cheeks. Her uneven pigmentation was also seen to diminish following Definisse™ Peel Program. She was likewise very satisfied and happy with the result of her treatment. Conclusion: The prejuvenation effect of a combination of minimal invasive procedures provides an optimal aesthetic option for millennials. The results obtained confirm the importance of the reharmonize approach to male and female aesthetics. And this is accomplished by working from deep to superficial facial, with satisfactory and long-lasting aesthetic outcomes.
背景:非手术微创手术,典型的结合,现在正在成为规范。这些模式的综合使用可以提供给千禧一代的患者,他们有独特的需求和审美目标。目的:我们旨在展示Definisse™填充剂,Definisse™螺纹和Definisse™剥离程序组合治疗两名千禧一代,一名女性和一名男性的效果。病例描述:在Definisse™填充剂和Definisse™线(双针和自由浮动)的帮助下,男性受试者的面部比例发生了明显的变化,颧骨和眶下区域的凹陷得到了矫正,下巴更加突出。使用Definisse™亮肤后,色素沉着也有明显改善,肤色更均匀、更清晰。病人用语言表达了对整体治疗效果的高度满意。女性受试者鼻梁凸起处有明显矫正。脸颊略微明显地向侧面和向上抬起。她不均匀的色素沉着也在Definisse™削皮程序后减少。她对治疗的结果也非常满意和高兴。结论:微创手术组合的预年轻化效果为千禧一代提供了最佳的美学选择。所得结果证实了再调和方法对男女美学的重要性。这是通过从面部深层到表层的工作来实现的,具有令人满意和持久的美学效果。
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引用次数: 0
期刊
Journal of clinical & experimental dermatology research
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