Pub Date : 2025-12-25DOI: 10.1016/j.jclinane.2025.112111
Zhen-Zhen Xu, Dong-Liang Mu
{"title":"Corrigendum to \"Unmasking the silent threat: Navigating the myocardial injury in oncological surgery\" [Journal of Clinical Anesthesia 108 (2026) 112063].","authors":"Zhen-Zhen Xu, Dong-Liang Mu","doi":"10.1016/j.jclinane.2025.112111","DOIUrl":"https://doi.org/10.1016/j.jclinane.2025.112111","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":" ","pages":"112111"},"PeriodicalIF":5.1,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jclinane.2025.112109
Neil S. Bailard MD , David W. Mercier MD , Christina A. Riccio MD , Catherine N. Vu MD , Peter W. Hsu MD , Rebekka Reinhardt MD , Paul A. Nakonezny PhD , Carin A. Hagberg MD
Background
Nasotracheal intubation (NTI) is often required for oropharyngeal surgery to maximize surgical access, but epistaxis is a common complication. NTI using a nasotracheal tube (NTT) telescoped into a red rubber urinary catheter (RRC) to guide the NTT and protect the nasal mucosa has been described for adults and studied in children but has not been systematically evaluated in adults.
Methods
This was a two-center, single-blinded, randomized controlled trial. 112 adults (mean age 57.1 ± 16.3 years, 61.6 % male) undergoing surgery requiring NTI were randomized 1: 1 to intubation with a thermosoftened, lubricated NTT, either alone or telescoped into an RRC to shield the beveled NTT tip. The primary outcome was incidence of epistaxis assessed at 5 min post-intubation by a blinded observer. Secondary outcomes included the severity of epistaxis, time to intubation, the rate of complications during nasotracheal intubation, and the degree of postoperative pain in PACU.
Results
Use of an RRC significantly reduced the likelihood of epistaxis (39.3 % vs. 62.5 %, Odds Ratio (OR) = 0.380, p = 0.0140; 95 % CI: 0.174 to 0.831, p = 0.0153; FDR = 0.0255) and the severity of epistaxis (OR for lower severity = 4.145; 95 % CI: 1.923 to 8.934, p = 0.0003; FDR = 0.0013), but was associated with a longer time to intubation (Least squares adjusted means 104.2 (SE = 6.87) seconds vs. 74.30 (SE = 6.86) seconds, p = 0.0005; FDR = 0.0015, d = 0.70). No difference was found in postoperative pain or in the rate of procedural complications.
Conclusions
Use of the RRC significantly reduced the likelihood and severity of epistaxis following nasal intubation, at the cost of longer time to intubation.
背景:鼻气管插管(NTI)通常需要口咽手术,以最大化手术通路,但鼻出血是一个常见的并发症。使用鼻气管管(NTT)插入红色橡胶导尿管(RRC)来引导鼻气管管(NTT)并保护鼻黏膜的NTI已被描述并在儿童中进行了研究,但尚未对成人进行系统评估。方法:双中心、单盲、随机对照试验。112名接受手术需要NTI的成年人(平均年龄57.1±16.3岁,61.6%为男性)被随机分为1:1组,分别使用热软化、润滑的NTT插管,或单独插管,或将其伸缩到RRC中以保护倾斜的NTT尖端。主要结局是在插管后5分钟由盲法观察者评估鼻衄的发生率。次要结局包括鼻出血严重程度、插管时间、鼻气管插管并发症发生率和PACU术后疼痛程度。结果:RRC的使用显著降低了鼻出血的可能性(39.3% vs. 62.5%,优势比(OR) = 0.380, p = 0.0140;95% CI: 0.174 ~ 0.831, p = 0.0153;FDR = 0.0255)和鼻出血严重程度(较低严重程度OR = 4.145; 95% CI: 1.923 ~ 8.934, p = 0.0003; FDR = 0.0013),但与插管时间较长相关(调整后最小二乘均值为104.2 (SE = 6.87)秒vs. 74.30 (SE = 6.86)秒,p = 0.0005;FDR = 0.0015, d = 0.70)。术后疼痛和手术并发症发生率无差异。结论:使用RRC显著降低鼻插管后鼻出血的可能性和严重程度,但代价是插管时间更长。
{"title":"Protection of the nasotracheal tube tip with a red rubber catheter in adults undergoing nasotracheal intubation: A randomized controlled trial","authors":"Neil S. Bailard MD , David W. Mercier MD , Christina A. Riccio MD , Catherine N. Vu MD , Peter W. Hsu MD , Rebekka Reinhardt MD , Paul A. Nakonezny PhD , Carin A. Hagberg MD","doi":"10.1016/j.jclinane.2025.112109","DOIUrl":"10.1016/j.jclinane.2025.112109","url":null,"abstract":"<div><h3>Background</h3><div>Nasotracheal intubation (NTI) is often required for oropharyngeal surgery to maximize surgical access, but epistaxis is a common complication. NTI using a nasotracheal tube (NTT) telescoped into a red rubber urinary catheter (RRC) to guide the NTT and protect the nasal mucosa has been described for adults and studied in children but has not been systematically evaluated in adults.</div></div><div><h3>Methods</h3><div>This was a two-center, single-blinded, randomized controlled trial. 112 adults (mean age 57.1 ± 16.3 years, 61.6 % male) undergoing surgery requiring NTI were randomized 1: 1 to intubation with a thermosoftened, lubricated NTT, either alone or telescoped into an RRC to shield the beveled NTT tip. The primary outcome was incidence of epistaxis assessed at 5 min post-intubation by a blinded observer. Secondary outcomes included the severity of epistaxis, time to intubation, the rate of complications during nasotracheal intubation, and the degree of postoperative pain in PACU.</div></div><div><h3>Results</h3><div>Use of an RRC significantly reduced the likelihood of epistaxis (39.3 % vs. 62.5 %, Odds Ratio (OR) = 0.380, <em>p</em> = 0.0140; 95 % CI: 0.174 to 0.831, <em>p</em> = 0.0153; FDR = 0.0255) and the severity of epistaxis (OR for lower severity = 4.145; 95 % CI: 1.923 to 8.934, <em>p</em> = 0.0003; FDR = 0.0013), but was associated with a longer time to intubation (Least squares adjusted means 104.2 (SE = 6.87) seconds vs. 74.30 (SE = 6.86) seconds, <em>p</em> = 0.0005; FDR = 0.0015, d = 0.70). No difference was found in postoperative pain or in the rate of procedural complications.</div></div><div><h3>Conclusions</h3><div>Use of the RRC significantly reduced the likelihood and severity of epistaxis following nasal intubation, at the cost of longer time to intubation.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112109"},"PeriodicalIF":5.1,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jclinane.2025.112106
Yu He M.D , Wei Zhao M.D. , Zhenyu Ze M.D. , Yan Zhao M.D. , Manyun Bao M.D. , Ming Yan M.D
Study objective
To evaluate whether there are differences in postoperative pain scores and the incidence of hemidiaphragmatic paralysis (HDP) between ultrasound-guided superior trunk block (STB) and infraspinatus teres minor fascial plane block (ITM).
A total of 100 patients aged 18 to 65 years scheduled for elective arthroscopic surgery were enrolled.
Interventions
Following sterile skin preparation, patients in the STB group received 15 mL of 0.375 % ropivacaine, while those in the ITM group received 25 mL of 0.375 % ropivacaine.
Measurements
The primary outcome was the highest resting pain score during the first 24 h postoperatively. Secondary outcomes included resting pain scores at six predefined time points (1, 3, 6, 9, 12,and 24 h), the incidence and severity of hemidiaphragmatic paralysis (HDP), block performance time, sensory block onset time, duration of analgesia, postoperative rescue analgesic consumption, grip strength, patient satisfaction scores, 24-h Quality of Recovery-15 (QoR-15) assessments, and Overall Benefit of Analgesia Scores (OBAS).
Main results
Within 24 h postoperation, the highest pain score was 3 [2.0–4.0] in the STB group and 3 [2.8 to 4.3] in the ITM group, with a median difference of 0 (95 % CI, −1 to 0). The upper limit of the 95 % CI was below the prespecified non-inferiority margin of 1″. (non-inferiority P < 0.01).
Conclusions
For maximal postoperative pain control within 24 h after shoulder arthroscopy, the ITM block was noninferior to STB, with significantly reduced diaphragmatic paralysis rates.
{"title":"Comparison between infraspinatus-Teres minor (ITM) Interfascial block and superior trunk block in shoulder arthroscopy: A randomized non-inferiority trial","authors":"Yu He M.D , Wei Zhao M.D. , Zhenyu Ze M.D. , Yan Zhao M.D. , Manyun Bao M.D. , Ming Yan M.D","doi":"10.1016/j.jclinane.2025.112106","DOIUrl":"10.1016/j.jclinane.2025.112106","url":null,"abstract":"<div><h3>Study objective</h3><div>To evaluate whether there are differences in postoperative pain scores and the incidence of hemidiaphragmatic paralysis (HDP) between ultrasound-guided superior trunk block (STB) and infraspinatus teres minor fascial plane block (ITM).</div></div><div><h3>Design</h3><div>Prospective, randomized controlled non-inferiority trial.</div></div><div><h3>Setting</h3><div>A tertiary hospital.</div></div><div><h3>Patients</h3><div>A total of 100 patients aged 18 to 65 years scheduled for elective arthroscopic surgery were enrolled.</div></div><div><h3>Interventions</h3><div>Following sterile skin preparation, patients in the STB group received 15 mL of 0.375 % ropivacaine, while those in the ITM group received 25 mL of 0.375 % ropivacaine.</div></div><div><h3>Measurements</h3><div>The primary outcome was the highest resting pain score during the first 24 h postoperatively. Secondary outcomes included resting pain scores at six predefined time points (1, 3, 6, 9, 12,and 24 h), the incidence and severity of hemidiaphragmatic paralysis (HDP), block performance time, sensory block onset time, duration of analgesia, postoperative rescue analgesic consumption, grip strength, patient satisfaction scores, 24-h Quality of Recovery-15 (QoR-15) assessments, and Overall Benefit of Analgesia Scores (OBAS).</div></div><div><h3>Main results</h3><div>Within 24 h postoperation, the highest pain score was 3 [2.0–4.0] in the STB group and 3 [2.8 to 4.3] in the ITM group, with a median difference of 0 (95 % CI, −1 to 0). The upper limit of the 95 % CI was below the prespecified non-inferiority margin of 1″. (non-inferiority <em>P</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>For maximal postoperative pain control within 24 h after shoulder arthroscopy, the ITM block was noninferior to STB, with significantly reduced diaphragmatic paralysis rates.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112106"},"PeriodicalIF":5.1,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-20DOI: 10.1016/j.jclinane.2025.112104
Paul Tauzi, Emilie Wargnier, Jeremy Klotz, Marie Dubillot, Sigismond Lasocki, Emmanuel Rineau
Introduction
Application of preoperative fasting rules appears insufficient despite the impact of excessive fasting on patient comfort and morbidity. Primary endpoint of the study was fasting durations before and after a multimodal awareness campaign about fasting rules.
Methods
This observational prospective study assessed liquid and solid fasting durations and their impact on recovery before and after a multimodal and multidisciplinary awareness campaign against excessive fasting. Fasting durations and data related to comfort and rehabilitation were collected at the admission to the operating room and on Day 1. Primary endpoint was the comparison of liquid and solid fasting times between the two groups. Secondary endpoints included quality of recovery.
Results
365 patients were included in the study in adult surgical departments, 185 during phase 1 from February to April 2023 and 179 during phase 2 from June to July 2023. Liquid fasting time were reduced in phase 2 with 7.5 [4.5–12.8] hours and 6.3 [3.7–11.3] hours in phase 1 and 2 (p < 0.001). Median solid fasting times were not reduced with 14.3 [12.3–17.0] hours in phase 1 versus 14.3 [12.4–16.5] in phase 2 (p = 0.66). Mean FQoR-15 recovery score was better in phase 2 compared to phase 1 (133 [CI 95 %: 129,6–136,1] vs 123 [CI 95 %: 119,3–125,8] respectively, p < 0.001).
Conclusions
After a multimodal awareness campaign, both median preoperative liquid fasting time and quality of recovery score were improved. However, the median solid fasting time was not reduced, calling for additional measures to further improve patient care.
尽管过度禁食对患者的舒适度和发病率有影响,但术前禁食规则的应用似乎不足。该研究的主要终点是禁食规则多模式意识运动前后的禁食持续时间。方法:本观察性前瞻性研究评估了液体和固体禁食持续时间,以及在多模式和多学科的反过度禁食意识运动前后对恢复的影响。在进入手术室和第1天收集禁食时间和与舒适和康复相关的数据。主要终点是两组之间液体和固体禁食时间的比较。次要终点包括恢复质量。结果共纳入成人外科365例患者,其中一期185例(2023年2月至4月),二期179例(2023年6月至7月)。第二阶段液体禁食时间缩短,第一阶段为7.5[4.5-12.8]小时,第二阶段为6.3[3.7-11.3]小时(p < 0.001)。中位固体禁食时间没有减少,第一阶段为14.3[12.3-17.0]小时,第二阶段为14.3[12.4-16.5]小时(p = 0.66)。2期患者的平均FQoR-15恢复评分优于1期患者(133 [CI 95%: 129,6 - 136,1] vs 123 [CI 95%: 119,3 - 125,8], p < 0.001)。结论多模式认知运动后,术前中位禁食时间和恢复评分质量均有提高。然而,中位固体禁食时间没有减少,需要采取额外措施进一步改善患者护理。
{"title":"Impact of a multimodal awareness campaign on preoperative fasting times and postoperative recovery: A prospective before-after study","authors":"Paul Tauzi, Emilie Wargnier, Jeremy Klotz, Marie Dubillot, Sigismond Lasocki, Emmanuel Rineau","doi":"10.1016/j.jclinane.2025.112104","DOIUrl":"10.1016/j.jclinane.2025.112104","url":null,"abstract":"<div><h3>Introduction</h3><div>Application of preoperative fasting rules appears insufficient despite the impact of excessive fasting on patient comfort and morbidity. Primary endpoint of the study was fasting durations before and after a multimodal awareness campaign about fasting rules.</div></div><div><h3>Methods</h3><div>This observational prospective study assessed liquid and solid fasting durations and their impact on recovery before and after a multimodal and multidisciplinary awareness campaign against excessive fasting. Fasting durations and data related to comfort and rehabilitation were collected at the admission to the operating room and on Day 1. Primary endpoint was the comparison of liquid and solid fasting times between the two groups. Secondary endpoints included quality of recovery.</div></div><div><h3>Results</h3><div>365 patients were included in the study in adult surgical departments, 185 during phase 1 from February to April 2023 and 179 during phase 2 from June to July 2023. Liquid fasting time were reduced in phase 2 with 7.5 [4.5–12.8] hours and 6.3 [3.7–11.3] hours in phase 1 and 2 (<em>p</em> < 0.001). Median solid fasting times were not reduced with 14.3 [12.3–17.0] hours in phase 1 versus 14.3 [12.4–16.5] in phase 2 (<em>p</em> = 0.66). Mean FQoR-15 recovery score was better in phase 2 compared to phase 1 (133 [CI 95 %: 129,6–136,1] vs 123 [CI 95 %: 119,3–125,8] respectively, <em>p</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>After a multimodal awareness campaign, both median preoperative liquid fasting time and quality of recovery score were improved. However, the median solid fasting time was not reduced, calling for additional measures to further improve patient care.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112104"},"PeriodicalIF":5.1,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.jclinane.2025.112099
Lu Dong , Fang Wen , Lu-Mei Qin , Xiao-Yan Zhi , Run Li , Yi Liang , Wen Song , Qun Xia , Jian Wu , Li Qiu , Qiang-Lin Yi , Yang Zhao , Li Yan , Fang-Zhou Yang , Shang Shi , Lu Chen , Jie-Qiong Luo , Wen-Qi Zhang , Li Zeng , Kun Zhou , Xiao-Hua Zou
Study objective
To assess the relationship between frailty and major postoperative complications (POCs) in elderly patients undergoing elective surgery.
Design
A prospective cohort study.
Setting
Five hospitals in China.
Patients
A total of 1358 elderly patients (≥65 years) were included.
Exposure
Preoperative frailty.
Measurements
The primary outcome was major POCs. LASSO regression was used for selecting covariates. Multivariate logistic regression modeling were used to evaluate the associations between frailty and major POCs. Net Reclassification Index (NRI) and Integrated Discriminant Improvement Index (IDI) were calculated to further assess the additional predictive value of the frailty for major POCs beyond the identified risk factors. Further subgroup analyses were conducted to determine the robustness of the associations.
Main results
Logistic regression modeling revealed that frailty was associated with major POCs (adjusted odds ratio [aOR], 95 % confidence interval [CI]: 2.61, 1.47–4.62). Each 1-point increase in frailty was associated with a 35 % increase in the risk of major POCs (aOR, 95 % CI: 1.35, 1.10–1.66). Slow walking speed, low physical activity and frequent exhaustion were independently associated with major POCs. Their ORs (95 % CI): 2.34 (1.33–4.13), 1.98 (1.09–3.57), 2.26 (1.28–3.99). Adding frailty to baseline risk model improved the predictive value of major POCs (NRI: 0.5551, 0.3095–0.8006; IDI: 0.0144, 0.0003–0.0286). Subgroup analyses revealed the same trend between frailty and major POCs.
Conclusions
Frail elderly patients scheduled for elective surgery were at an increased risk of major POCs, especially those with slow walking speed, low levels of physical activity, and frequent feelings of exhaustion.
{"title":"Associations between preoperative frailty and major postoperative complications in older surgical patients","authors":"Lu Dong , Fang Wen , Lu-Mei Qin , Xiao-Yan Zhi , Run Li , Yi Liang , Wen Song , Qun Xia , Jian Wu , Li Qiu , Qiang-Lin Yi , Yang Zhao , Li Yan , Fang-Zhou Yang , Shang Shi , Lu Chen , Jie-Qiong Luo , Wen-Qi Zhang , Li Zeng , Kun Zhou , Xiao-Hua Zou","doi":"10.1016/j.jclinane.2025.112099","DOIUrl":"10.1016/j.jclinane.2025.112099","url":null,"abstract":"<div><h3>Study objective</h3><div>To assess the relationship between frailty and major postoperative complications (POCs) in elderly patients undergoing elective surgery.</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting</h3><div>Five hospitals in China.</div></div><div><h3>Patients</h3><div>A total of 1358 elderly patients (≥65 years) were included.</div></div><div><h3>Exposure</h3><div>Preoperative frailty.</div></div><div><h3>Measurements</h3><div>The primary outcome was major POCs. LASSO regression was used for selecting covariates. Multivariate logistic regression modeling were used to evaluate the associations between frailty and major POCs. Net Reclassification Index (NRI) and Integrated Discriminant Improvement Index (IDI) were calculated to further assess the additional predictive value of the frailty for major POCs beyond the identified risk factors. Further subgroup analyses were conducted to determine the robustness of the associations.</div></div><div><h3>Main results</h3><div>Logistic regression modeling revealed that frailty was associated with major POCs (adjusted odds ratio [aOR], 95 % confidence interval [CI]: 2.61, 1.47–4.62). Each 1-point increase in frailty was associated with a 35 % increase in the risk of major POCs (aOR, 95 % CI: 1.35, 1.10–1.66). Slow walking speed, low physical activity and frequent exhaustion were independently associated with major POCs. Their ORs (95 % CI): 2.34 (1.33–4.13), 1.98 (1.09–3.57), 2.26 (1.28–3.99). Adding frailty to baseline risk model improved the predictive value of major POCs (NRI: 0.5551, 0.3095–0.8006; IDI: 0.0144, 0.0003–0.0286). Subgroup analyses revealed the same trend between frailty and major POCs.</div></div><div><h3>Conclusions</h3><div>Frail elderly patients scheduled for elective surgery were at an increased risk of major POCs, especially those with slow walking speed, low levels of physical activity, and frequent feelings of exhaustion.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112099"},"PeriodicalIF":5.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.jclinane.2025.112105
Wesley L. Allen , Kiran S. Merchant , Archer K. Martin, Shaun E. Gruenbaum, Benjamin F. Gruenbaum
Acute intracranial injuries including subarachnoid hemorrhage, traumatic brain injury, stroke, and seizures often trigger cardiovascular and pulmonary complications through the neurocardiac axis. This bidirectional connection between the brain and the heart is mediated by sympathetic overactivity, catecholamine excess, autonomic imbalance, and systemic inflammation. This narrative review synthesizes current evidence published between 1968 and 2025, identified through a comprehensive literature search. Representative studies were selected to provide an integrative overview of neurocardiac complications in acute neurologic injury, focusing on underlying mechanisms, clinical manifestations, diagnostic challenges, and management strategies. We describe the mechanisms underlying neurogenic stunned myocardium and Takotsubo syndrome, highlighting regional vulnerability based on autonomic innervation. Electrocardiographic features, cardiac biomarkers, and echocardiographic findings are discussed in the context of early recognition and risk stratification. We further examine diagnostic challenges, the importance of distinguishing neurologic from primary cardiac pathology, and therapeutic approaches including autonomic modulation and cardiopulmonary protective strategies. Understanding the unique pathogenesis of these syndromes can help guide individualized treatment strategies and anesthetic management to improve outcomes in patients with acute neurologic injury. By consolidating multidisciplinary insights, this review aims to enhance recognition and management of neurocardiac complications in this population.
{"title":"The neurocardiac axis in acute intracranial stress","authors":"Wesley L. Allen , Kiran S. Merchant , Archer K. Martin, Shaun E. Gruenbaum, Benjamin F. Gruenbaum","doi":"10.1016/j.jclinane.2025.112105","DOIUrl":"10.1016/j.jclinane.2025.112105","url":null,"abstract":"<div><div>Acute intracranial injuries including subarachnoid hemorrhage, traumatic brain injury, stroke, and seizures often trigger cardiovascular and pulmonary complications through the neurocardiac axis. This bidirectional connection between the brain and the heart is mediated by sympathetic overactivity, catecholamine excess, autonomic imbalance, and systemic inflammation. This narrative review synthesizes current evidence published between 1968 and 2025, identified through a comprehensive literature search. Representative studies were selected to provide an integrative overview of neurocardiac complications in acute neurologic injury, focusing on underlying mechanisms, clinical manifestations, diagnostic challenges, and management strategies. We describe the mechanisms underlying neurogenic stunned myocardium and Takotsubo syndrome, highlighting regional vulnerability based on autonomic innervation. Electrocardiographic features, cardiac biomarkers, and echocardiographic findings are discussed in the context of early recognition and risk stratification. We further examine diagnostic challenges, the importance of distinguishing neurologic from primary cardiac pathology, and therapeutic approaches including autonomic modulation and cardiopulmonary protective strategies. Understanding the unique pathogenesis of these syndromes can help guide individualized treatment strategies and anesthetic management to improve outcomes in patients with acute neurologic injury. By consolidating multidisciplinary insights, this review aims to enhance recognition and management of neurocardiac complications in this population.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112105"},"PeriodicalIF":5.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.jclinane.2025.112097
Daniel D. King , Rhea Temmermand , Jennifer E. Greenwood
Background
Cannabis use is increasingly common, yet its effects on postoperative pain and opioid requirements remain unclear. While cannabinoids are used in chronic pain, their role in acute perioperative recovery is less defined.
Methods
A systematic search of PubMed, CINAHL, and Embase identified studies published within the past ten years that examined preoperative cannabis use and its relationship with postoperative pain and opioid consumption. Forty-two studies met the inclusion criteria. Data were extracted and summarized using a narrative synthesis methodology.
Results
Exposure definitions, surgical specialties, and outcome metrics were heterogeneous, limiting cross-study comparability; therefore, effects were reported in their native form without pooling. Of the 42 included studies, 14 (33.3 %) found that cannabis users reported higher postoperative pain, 10 (23.8 %) reported no difference, 2 (4.8 %) suggested reduced pain, and 16 (38.1 %) did not report pain outcomes. Regarding opioids, 18 studies (42.9 %) indicated greater postoperative requirements, 17 (40.5 %) found no difference, 3 (7.1 %) suggested reduced use, and 4 (9.5 %) did not report opioid outcomes. Specialty-specific patterns emerged: mixed cohorts (90 %) and spine populations (55 %) more frequently reported increased opioid use, whereas arthroplasty studies more often reported no difference (62 %). Limited, low-certainty evidence suggested that resuming cannabis after discharge was associated with lower persistent opioid use.
Conclusions
Preoperative cannabis exposure is associated with increased postoperative pain and opioid requirements in some, but not all, surgical contexts. Outcomes vary by specialty, and residual confounding and nonstandardized exposure measurement constrain inference, underscoring the need for standardized exposure definitions, prospective designs, and individualized perioperative pain strategies.
{"title":"Preoperative cannabinoid exposure and postoperative pain: A narrative review","authors":"Daniel D. King , Rhea Temmermand , Jennifer E. Greenwood","doi":"10.1016/j.jclinane.2025.112097","DOIUrl":"10.1016/j.jclinane.2025.112097","url":null,"abstract":"<div><h3>Background</h3><div>Cannabis use is increasingly common, yet its effects on postoperative pain and opioid requirements remain unclear. While cannabinoids are used in chronic pain, their role in acute perioperative recovery is less defined.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, CINAHL, and Embase identified studies published within the past ten years that examined preoperative cannabis use and its relationship with postoperative pain and opioid consumption. Forty-two studies met the inclusion criteria. Data were extracted and summarized using a narrative synthesis methodology.</div></div><div><h3>Results</h3><div>Exposure definitions, surgical specialties, and outcome metrics were heterogeneous, limiting cross-study comparability; therefore, effects were reported in their native form without pooling. Of the 42 included studies, 14 (33.3 %) found that cannabis users reported higher postoperative pain, 10 (23.8 %) reported no difference, 2 (4.8 %) suggested reduced pain, and 16 (38.1 %) did not report pain outcomes. Regarding opioids, 18 studies (42.9 %) indicated greater postoperative requirements, 17 (40.5 %) found no difference, 3 (7.1 %) suggested reduced use, and 4 (9.5 %) did not report opioid outcomes. Specialty-specific patterns emerged: mixed cohorts (90 %) and spine populations (55 %) more frequently reported increased opioid use, whereas arthroplasty studies more often reported no difference (62 %). Limited, low-certainty evidence suggested that resuming cannabis after discharge was associated with lower persistent opioid use.</div></div><div><h3>Conclusions</h3><div>Preoperative cannabis exposure is associated with increased postoperative pain and opioid requirements in some, but not all, surgical contexts. Outcomes vary by specialty, and residual confounding and nonstandardized exposure measurement constrain inference, underscoring the need for standardized exposure definitions, prospective designs, and individualized perioperative pain strategies.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112097"},"PeriodicalIF":5.1,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jclinane.2025.112101
Anne B. Alnor , Rasmus B. Lynggaard , Lina E. Pedersen , Jonas Storgaard , Martin S. Laursen , Pernille J. Vinholt
{"title":"Extracting intraoperative blood loss from unstructured clinical narratives","authors":"Anne B. Alnor , Rasmus B. Lynggaard , Lina E. Pedersen , Jonas Storgaard , Martin S. Laursen , Pernille J. Vinholt","doi":"10.1016/j.jclinane.2025.112101","DOIUrl":"10.1016/j.jclinane.2025.112101","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112101"},"PeriodicalIF":5.1,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jclinane.2025.112103
Michael Kolland , Selina Sartori , Christoph Klivinyi , Michael Schörghuber , Jakob Pannold , Igor Knez , Alexander H. Kirsch , Nikolaus Schreiber
Background
Acute kidney injury (AKI) is a common complication after coronary artery bypass grafting (CABG), associated with adverse short- and long-term outcomes. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce occurrence of AKI in several populations, yet their perioperative effects in patients undergoing CABG are unknown.
Methods
We conducted a retrospective study at the Department of Cardiac Surgery, Medical University of Graz (2020–2024) to evaluate the impact of preoperative SGLT2i use on cardiac surgery–associated AKI in adults undergoing urgent or emergent isolated coronary artery bypass grafting in patients with an indication for SGLT2i therapy (type 2 diabetes mellitus, heart failure with reduced ejection fraction, or chronic kidney disease). Patients with preoperative dialysis, sepsis, reoperation, mechanical circulatory support or missing laboratory data were excluded. Exposure was defined as SGLT2i use within two weeks before surgery, and the primary outcome was cardiac surgery-associated AKI (CSA-AKI) according to KDIGO criteria. Secondary outcomes included kidney replacement therapy, ICU length of stay, 30-day mortality and postoperative diabetic ketoacidosis. Causal effects were estimated using entropy balancing. Results were reported as weighted risk differences, risk ratios, and adjusted mean differences, with time-to-event outcomes analyzed via weighted Cox models and Kaplan–Meier estimates.
Results
Among 484 patients, 135 were on SGLT2i. CSA-AKI occurred in 23.0 % of SGLT2i users vs. 28.1 % of non-users (risk ratio of 0.63 [95 % CI 0.44–0.91; p = 0.014]). The association was pronounced in patients with heart failure with reduced ejection fraction and those with high EuroSCORE II. No differences were observed in other secondary endpoints and no cases of postoperative diabetic ketoacidosis occurred.
Conclusion
Preoperative SGLT2i use was associated with a significantly lower risk of CSA-AKI in patients undergoing urgent or emergent CABG. These findings need to be confirmed in prospective multicenter trials but underline the favorable safety profile of this medication.
背景:急性肾损伤(AKI)是冠状动脉旁路移植术(CABG)后常见的并发症,与不良的短期和长期预后相关。钠-葡萄糖共转运蛋白-2抑制剂(SGLT2i)已被证明可以减少几个人群AKI的发生,但其在CABG患者的围手术期效果尚不清楚。方法:我们在格拉茨医科大学心脏外科(2020-2024)进行了一项回顾性研究,以评估术前使用SGLT2i对有SGLT2i治疗指征(2型糖尿病、心力衰竭伴射血分数降低或慢性肾病)的成人紧急或紧急孤立冠状动脉旁路移植术中心脏手术相关AKI的影响。排除术前透析、败血症、再手术、机械循环支持或缺少实验室数据的患者。暴露被定义为术前两周内使用SGLT2i,根据KDIGO标准,主要结局是心脏手术相关AKI (CSA-AKI)。次要结局包括肾脏替代治疗、ICU住院时间、30天死亡率和术后糖尿病酮症酸中毒。利用熵平衡估计因果效应。结果报告为加权风险差异、风险比和调整后的平均差异,并通过加权Cox模型和Kaplan-Meier估计分析事件发生时间。结果:484例患者中,有135例接受SGLT2i治疗。SGLT2i使用者中CSA-AKI发生率为23.0%,非使用者中为28.1%(风险比为0.63 [95% CI 0.44-0.91; p = 0.014])。在射血分数降低的心力衰竭患者和EuroSCORE II高的患者中,这种关联明显。其他次要终点无差异,术后无糖尿病酮症酸中毒病例发生。结论:术前使用SGLT2i与急诊或紧急冠脉搭桥患者CSA-AKI风险显著降低相关。这些发现需要在前瞻性多中心试验中得到证实,但强调了该药物的良好安全性。
{"title":"Preoperative SGLT2i therapy and acute kidney injury in patients undergoing emergency and urgent coronary artery bypass grafting - A causal inference framework","authors":"Michael Kolland , Selina Sartori , Christoph Klivinyi , Michael Schörghuber , Jakob Pannold , Igor Knez , Alexander H. Kirsch , Nikolaus Schreiber","doi":"10.1016/j.jclinane.2025.112103","DOIUrl":"10.1016/j.jclinane.2025.112103","url":null,"abstract":"<div><h3>Background</h3><div>Acute kidney injury (AKI) is a common complication after coronary artery bypass grafting (CABG), associated with adverse short- and long-term outcomes. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce occurrence of AKI in several populations, yet their perioperative effects in patients undergoing CABG are unknown.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study at the Department of Cardiac Surgery, Medical University of Graz (2020–2024) to evaluate the impact of preoperative SGLT2i use on cardiac surgery–associated AKI in adults undergoing urgent or emergent isolated coronary artery bypass grafting in patients with an indication for SGLT2i therapy (type 2 diabetes mellitus, heart failure with reduced ejection fraction, or chronic kidney disease). Patients with preoperative dialysis, sepsis, reoperation, mechanical circulatory support or missing laboratory data were excluded. Exposure was defined as SGLT2i use within two weeks before surgery, and the primary outcome was cardiac surgery-associated AKI (CSA-AKI) according to KDIGO criteria. Secondary outcomes included kidney replacement therapy, ICU length of stay, 30-day mortality and postoperative diabetic ketoacidosis. Causal effects were estimated using entropy balancing. Results were reported as weighted risk differences, risk ratios, and adjusted mean differences, with time-to-event outcomes analyzed via weighted Cox models and Kaplan–Meier estimates.</div></div><div><h3>Results</h3><div>Among 484 patients, 135 were on SGLT2i. CSA-AKI occurred in 23.0 % of SGLT2i users vs. 28.1 % of non-users (risk ratio of 0.63 [95 % CI 0.44–0.91; <em>p</em> = 0.014]). The association was pronounced in patients with heart failure with reduced ejection fraction and those with high EuroSCORE II. No differences were observed in other secondary endpoints and no cases of postoperative diabetic ketoacidosis occurred.</div></div><div><h3>Conclusion</h3><div>Preoperative SGLT2i use was associated with a significantly lower risk of CSA-AKI in patients undergoing urgent or emergent CABG. These findings need to be confirmed in prospective multicenter trials but underline the favorable safety profile of this medication.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112103"},"PeriodicalIF":5.1,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jclinane.2025.112095
Aubrey Samost-Williams, Alparslan Turan, Victoria Tang
{"title":"Beyond the operating room: Holistic support for frail surgical patients.","authors":"Aubrey Samost-Williams, Alparslan Turan, Victoria Tang","doi":"10.1016/j.jclinane.2025.112095","DOIUrl":"https://doi.org/10.1016/j.jclinane.2025.112095","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":" ","pages":"112095"},"PeriodicalIF":5.1,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}