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Corrigendum to "Unmasking the silent threat: Navigating the myocardial injury in oncological surgery" [Journal of Clinical Anesthesia 108 (2026) 112063]. “揭露无声的威胁:在肿瘤手术中导航心肌损伤”的更正[临床麻醉杂志108(2026)112063]。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-25 DOI: 10.1016/j.jclinane.2025.112111
Zhen-Zhen Xu, Dong-Liang Mu
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引用次数: 0
Protection of the nasotracheal tube tip with a red rubber catheter in adults undergoing nasotracheal intubation: A randomized controlled trial 用红色橡胶导管保护鼻气管插管成人鼻气管管尖端:一项随机对照试验。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-24 DOI: 10.1016/j.jclinane.2025.112109
Neil S. Bailard MD , David W. Mercier MD , Christina A. Riccio MD , Catherine N. Vu MD , Peter W. Hsu MD , Rebekka Reinhardt MD , Paul A. Nakonezny PhD , Carin A. Hagberg MD

Background

Nasotracheal intubation (NTI) is often required for oropharyngeal surgery to maximize surgical access, but epistaxis is a common complication. NTI using a nasotracheal tube (NTT) telescoped into a red rubber urinary catheter (RRC) to guide the NTT and protect the nasal mucosa has been described for adults and studied in children but has not been systematically evaluated in adults.

Methods

This was a two-center, single-blinded, randomized controlled trial. 112 adults (mean age 57.1 ± 16.3 years, 61.6 % male) undergoing surgery requiring NTI were randomized 1: 1 to intubation with a thermosoftened, lubricated NTT, either alone or telescoped into an RRC to shield the beveled NTT tip. The primary outcome was incidence of epistaxis assessed at 5 min post-intubation by a blinded observer. Secondary outcomes included the severity of epistaxis, time to intubation, the rate of complications during nasotracheal intubation, and the degree of postoperative pain in PACU.

Results

Use of an RRC significantly reduced the likelihood of epistaxis (39.3 % vs. 62.5 %, Odds Ratio (OR) = 0.380, p = 0.0140; 95 % CI: 0.174 to 0.831, p = 0.0153; FDR = 0.0255) and the severity of epistaxis (OR for lower severity = 4.145; 95 % CI: 1.923 to 8.934, p = 0.0003; FDR = 0.0013), but was associated with a longer time to intubation (Least squares adjusted means 104.2 (SE = 6.87) seconds vs. 74.30 (SE = 6.86) seconds, p = 0.0005; FDR = 0.0015, d = 0.70). No difference was found in postoperative pain or in the rate of procedural complications.

Conclusions

Use of the RRC significantly reduced the likelihood and severity of epistaxis following nasal intubation, at the cost of longer time to intubation.
背景:鼻气管插管(NTI)通常需要口咽手术,以最大化手术通路,但鼻出血是一个常见的并发症。使用鼻气管管(NTT)插入红色橡胶导尿管(RRC)来引导鼻气管管(NTT)并保护鼻黏膜的NTI已被描述并在儿童中进行了研究,但尚未对成人进行系统评估。方法:双中心、单盲、随机对照试验。112名接受手术需要NTI的成年人(平均年龄57.1±16.3岁,61.6%为男性)被随机分为1:1组,分别使用热软化、润滑的NTT插管,或单独插管,或将其伸缩到RRC中以保护倾斜的NTT尖端。主要结局是在插管后5分钟由盲法观察者评估鼻衄的发生率。次要结局包括鼻出血严重程度、插管时间、鼻气管插管并发症发生率和PACU术后疼痛程度。结果:RRC的使用显著降低了鼻出血的可能性(39.3% vs. 62.5%,优势比(OR) = 0.380, p = 0.0140;95% CI: 0.174 ~ 0.831, p = 0.0153;FDR = 0.0255)和鼻出血严重程度(较低严重程度OR = 4.145; 95% CI: 1.923 ~ 8.934, p = 0.0003; FDR = 0.0013),但与插管时间较长相关(调整后最小二乘均值为104.2 (SE = 6.87)秒vs. 74.30 (SE = 6.86)秒,p = 0.0005;FDR = 0.0015, d = 0.70)。术后疼痛和手术并发症发生率无差异。结论:使用RRC显著降低鼻插管后鼻出血的可能性和严重程度,但代价是插管时间更长。
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引用次数: 0
Comparison between infraspinatus-Teres minor (ITM) Interfascial block and superior trunk block in shoulder arthroscopy: A randomized non-inferiority trial 肩关节镜下小粗圆肌(ITM)筋膜间阻滞和上干阻滞的比较:一项随机非效性试验。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-24 DOI: 10.1016/j.jclinane.2025.112106
Yu He M.D , Wei Zhao M.D. , Zhenyu Ze M.D. , Yan Zhao M.D. , Manyun Bao M.D. , Ming Yan M.D

Study objective

To evaluate whether there are differences in postoperative pain scores and the incidence of hemidiaphragmatic paralysis (HDP) between ultrasound-guided superior trunk block (STB) and infraspinatus teres minor fascial plane block (ITM).

Design

Prospective, randomized controlled non-inferiority trial.

Setting

A tertiary hospital.

Patients

A total of 100 patients aged 18 to 65 years scheduled for elective arthroscopic surgery were enrolled.

Interventions

Following sterile skin preparation, patients in the STB group received 15 mL of 0.375 % ropivacaine, while those in the ITM group received 25 mL of 0.375 % ropivacaine.

Measurements

The primary outcome was the highest resting pain score during the first 24 h postoperatively. Secondary outcomes included resting pain scores at six predefined time points (1, 3, 6, 9, 12,and 24 h), the incidence and severity of hemidiaphragmatic paralysis (HDP), block performance time, sensory block onset time, duration of analgesia, postoperative rescue analgesic consumption, grip strength, patient satisfaction scores, 24-h Quality of Recovery-15 (QoR-15) assessments, and Overall Benefit of Analgesia Scores (OBAS).

Main results

Within 24 h postoperation, the highest pain score was 3 [2.0–4.0] in the STB group and 3 [2.8 to 4.3] in the ITM group, with a median difference of 0 (95 % CI, −1 to 0). The upper limit of the 95 % CI was below the prespecified non-inferiority margin of 1″. (non-inferiority P < 0.01).

Conclusions

For maximal postoperative pain control within 24 h after shoulder arthroscopy, the ITM block was noninferior to STB, with significantly reduced diaphragmatic paralysis rates.
研究目的:评价超声引导下上干阻滞(STB)与圆肌下小筋膜平面阻滞(ITM)在术后疼痛评分及半膈肌麻痹(HDP)发生率方面是否存在差异。设计:前瞻性、随机对照非劣效性试验。环境:三级医院。患者:共纳入100例年龄在18至65岁之间的患者,计划进行选择性关节镜手术。干预措施:无菌皮肤准备后,STB组患者接受0.375%罗哌卡因15 mL, ITM组患者接受0.375%罗哌卡因25 mL。测量:主要结果是术后24小时内静息疼痛评分最高。次要结果包括六个预定义时间点(1,3,6,9,12,24 h)的静息疼痛评分,半断性麻痹(HDP)的发生率和严重程度,阻滞时间,感觉阻滞发生时间,镇痛持续时间,术后抢救镇痛消耗,握力,患者满意度评分,24小时恢复质量-15 (QoR-15)评估,以及镇痛评分的总体获益(OBAS)。主要结果:术后24 h内,STB组疼痛评分最高为3分[2.0 ~ 4.0],ITM组疼痛评分最高为3分[2.8 ~ 4.3],中位差为0 (95% CI, -1 ~ 0)。95% CI的上限低于预定的非劣效性界限1″。结论:肩关节镜术后24小时内最大限度地控制术后疼痛,ITM阻滞优于STB,可显著降低膈肌麻痹率。
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引用次数: 0
Impact of a multimodal awareness campaign on preoperative fasting times and postoperative recovery: A prospective before-after study 多模式意识运动对术前禁食时间和术后恢复的影响:一项前瞻性的前后研究
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-20 DOI: 10.1016/j.jclinane.2025.112104
Paul Tauzi, Emilie Wargnier, Jeremy Klotz, Marie Dubillot, Sigismond Lasocki, Emmanuel Rineau

Introduction

Application of preoperative fasting rules appears insufficient despite the impact of excessive fasting on patient comfort and morbidity. Primary endpoint of the study was fasting durations before and after a multimodal awareness campaign about fasting rules.

Methods

This observational prospective study assessed liquid and solid fasting durations and their impact on recovery before and after a multimodal and multidisciplinary awareness campaign against excessive fasting. Fasting durations and data related to comfort and rehabilitation were collected at the admission to the operating room and on Day 1. Primary endpoint was the comparison of liquid and solid fasting times between the two groups. Secondary endpoints included quality of recovery.

Results

365 patients were included in the study in adult surgical departments, 185 during phase 1 from February to April 2023 and 179 during phase 2 from June to July 2023. Liquid fasting time were reduced in phase 2 with 7.5 [4.5–12.8] hours and 6.3 [3.7–11.3] hours in phase 1 and 2 (p < 0.001). Median solid fasting times were not reduced with 14.3 [12.3–17.0] hours in phase 1 versus 14.3 [12.4–16.5] in phase 2 (p = 0.66). Mean FQoR-15 recovery score was better in phase 2 compared to phase 1 (133 [CI 95 %: 129,6–136,1] vs 123 [CI 95 %: 119,3–125,8] respectively, p < 0.001).

Conclusions

After a multimodal awareness campaign, both median preoperative liquid fasting time and quality of recovery score were improved. However, the median solid fasting time was not reduced, calling for additional measures to further improve patient care.
尽管过度禁食对患者的舒适度和发病率有影响,但术前禁食规则的应用似乎不足。该研究的主要终点是禁食规则多模式意识运动前后的禁食持续时间。方法:本观察性前瞻性研究评估了液体和固体禁食持续时间,以及在多模式和多学科的反过度禁食意识运动前后对恢复的影响。在进入手术室和第1天收集禁食时间和与舒适和康复相关的数据。主要终点是两组之间液体和固体禁食时间的比较。次要终点包括恢复质量。结果共纳入成人外科365例患者,其中一期185例(2023年2月至4月),二期179例(2023年6月至7月)。第二阶段液体禁食时间缩短,第一阶段为7.5[4.5-12.8]小时,第二阶段为6.3[3.7-11.3]小时(p < 0.001)。中位固体禁食时间没有减少,第一阶段为14.3[12.3-17.0]小时,第二阶段为14.3[12.4-16.5]小时(p = 0.66)。2期患者的平均FQoR-15恢复评分优于1期患者(133 [CI 95%: 129,6 - 136,1] vs 123 [CI 95%: 119,3 - 125,8], p < 0.001)。结论多模式认知运动后,术前中位禁食时间和恢复评分质量均有提高。然而,中位固体禁食时间没有减少,需要采取额外措施进一步改善患者护理。
{"title":"Impact of a multimodal awareness campaign on preoperative fasting times and postoperative recovery: A prospective before-after study","authors":"Paul Tauzi,&nbsp;Emilie Wargnier,&nbsp;Jeremy Klotz,&nbsp;Marie Dubillot,&nbsp;Sigismond Lasocki,&nbsp;Emmanuel Rineau","doi":"10.1016/j.jclinane.2025.112104","DOIUrl":"10.1016/j.jclinane.2025.112104","url":null,"abstract":"<div><h3>Introduction</h3><div>Application of preoperative fasting rules appears insufficient despite the impact of excessive fasting on patient comfort and morbidity. Primary endpoint of the study was fasting durations before and after a multimodal awareness campaign about fasting rules.</div></div><div><h3>Methods</h3><div>This observational prospective study assessed liquid and solid fasting durations and their impact on recovery before and after a multimodal and multidisciplinary awareness campaign against excessive fasting. Fasting durations and data related to comfort and rehabilitation were collected at the admission to the operating room and on Day 1. Primary endpoint was the comparison of liquid and solid fasting times between the two groups. Secondary endpoints included quality of recovery.</div></div><div><h3>Results</h3><div>365 patients were included in the study in adult surgical departments, 185 during phase 1 from February to April 2023 and 179 during phase 2 from June to July 2023. Liquid fasting time were reduced in phase 2 with 7.5 [4.5–12.8] hours and 6.3 [3.7–11.3] hours in phase 1 and 2 (<em>p</em> &lt; 0.001). Median solid fasting times were not reduced with 14.3 [12.3–17.0] hours in phase 1 versus 14.3 [12.4–16.5] in phase 2 (<em>p</em> = 0.66). Mean FQoR-15 recovery score was better in phase 2 compared to phase 1 (133 [CI 95 %: 129,6–136,1] vs 123 [CI 95 %: 119,3–125,8] respectively, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>After a multimodal awareness campaign, both median preoperative liquid fasting time and quality of recovery score were improved. However, the median solid fasting time was not reduced, calling for additional measures to further improve patient care.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112104"},"PeriodicalIF":5.1,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between preoperative frailty and major postoperative complications in older surgical patients 老年外科患者术前虚弱与术后主要并发症的关系。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-17 DOI: 10.1016/j.jclinane.2025.112099
Lu Dong , Fang Wen , Lu-Mei Qin , Xiao-Yan Zhi , Run Li , Yi Liang , Wen Song , Qun Xia , Jian Wu , Li Qiu , Qiang-Lin Yi , Yang Zhao , Li Yan , Fang-Zhou Yang , Shang Shi , Lu Chen , Jie-Qiong Luo , Wen-Qi Zhang , Li Zeng , Kun Zhou , Xiao-Hua Zou

Study objective

To assess the relationship between frailty and major postoperative complications (POCs) in elderly patients undergoing elective surgery.

Design

A prospective cohort study.

Setting

Five hospitals in China.

Patients

A total of 1358 elderly patients (≥65 years) were included.

Exposure

Preoperative frailty.

Measurements

The primary outcome was major POCs. LASSO regression was used for selecting covariates. Multivariate logistic regression modeling were used to evaluate the associations between frailty and major POCs. Net Reclassification Index (NRI) and Integrated Discriminant Improvement Index (IDI) were calculated to further assess the additional predictive value of the frailty for major POCs beyond the identified risk factors. Further subgroup analyses were conducted to determine the robustness of the associations.

Main results

Logistic regression modeling revealed that frailty was associated with major POCs (adjusted odds ratio [aOR], 95 % confidence interval [CI]: 2.61, 1.47–4.62). Each 1-point increase in frailty was associated with a 35 % increase in the risk of major POCs (aOR, 95 % CI: 1.35, 1.10–1.66). Slow walking speed, low physical activity and frequent exhaustion were independently associated with major POCs. Their ORs (95 % CI): 2.34 (1.33–4.13), 1.98 (1.09–3.57), 2.26 (1.28–3.99). Adding frailty to baseline risk model improved the predictive value of major POCs (NRI: 0.5551, 0.3095–0.8006; IDI: 0.0144, 0.0003–0.0286). Subgroup analyses revealed the same trend between frailty and major POCs.

Conclusions

Frail elderly patients scheduled for elective surgery were at an increased risk of major POCs, especially those with slow walking speed, low levels of physical activity, and frequent feelings of exhaustion.
研究目的:探讨老年择期手术患者衰弱与主要术后并发症(POCs)的关系。设计:前瞻性队列研究。背景:中国的五家医院。患者:共纳入1358例老年患者(≥65岁)。暴露:术前虚弱。测量:主要终点为主要POCs。采用LASSO回归选择协变量。采用多变量logistic回归模型评估虚弱与主要POCs之间的关系。计算净重分类指数(NRI)和综合判别改善指数(IDI),进一步评估脆弱性对主要POCs的附加预测价值。进一步进行亚组分析以确定这些关联的稳健性。主要结果:Logistic回归模型显示,虚弱与主要POCs相关(调整优势比[aOR], 95%可信区间[CI]: 2.61, 1.47-4.62)。虚弱程度每增加1分,发生主要POCs的风险增加35% (aOR, 95% CI: 1.35, 1.10-1.66)。步行速度慢、体力活动少和经常疲惫与主要POCs独立相关。口服补液盐(95% CI): 2.34(1.33 - -4.13), 1.98(1.09 - -3.57), 2.26(1.28 - -3.99)。在基线风险模型中加入脆弱性可提高主要POCs的预测值(NRI: 0.5551, 0.3095 ~ 0.8006; IDI: 0.0144, 0.0003 ~ 0.0286)。亚组分析显示,虚弱和主要POCs之间存在相同的趋势。结论:计划择期手术的体弱老年患者发生主要POCs的风险增加,特别是那些行走速度慢、体力活动水平低、经常感到疲惫的患者。
{"title":"Associations between preoperative frailty and major postoperative complications in older surgical patients","authors":"Lu Dong ,&nbsp;Fang Wen ,&nbsp;Lu-Mei Qin ,&nbsp;Xiao-Yan Zhi ,&nbsp;Run Li ,&nbsp;Yi Liang ,&nbsp;Wen Song ,&nbsp;Qun Xia ,&nbsp;Jian Wu ,&nbsp;Li Qiu ,&nbsp;Qiang-Lin Yi ,&nbsp;Yang Zhao ,&nbsp;Li Yan ,&nbsp;Fang-Zhou Yang ,&nbsp;Shang Shi ,&nbsp;Lu Chen ,&nbsp;Jie-Qiong Luo ,&nbsp;Wen-Qi Zhang ,&nbsp;Li Zeng ,&nbsp;Kun Zhou ,&nbsp;Xiao-Hua Zou","doi":"10.1016/j.jclinane.2025.112099","DOIUrl":"10.1016/j.jclinane.2025.112099","url":null,"abstract":"<div><h3>Study objective</h3><div>To assess the relationship between frailty and major postoperative complications (POCs) in elderly patients undergoing elective surgery.</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting</h3><div>Five hospitals in China.</div></div><div><h3>Patients</h3><div>A total of 1358 elderly patients (≥65 years) were included.</div></div><div><h3>Exposure</h3><div>Preoperative frailty.</div></div><div><h3>Measurements</h3><div>The primary outcome was major POCs. LASSO regression was used for selecting covariates. Multivariate logistic regression modeling were used to evaluate the associations between frailty and major POCs. Net Reclassification Index (NRI) and Integrated Discriminant Improvement Index (IDI) were calculated to further assess the additional predictive value of the frailty for major POCs beyond the identified risk factors. Further subgroup analyses were conducted to determine the robustness of the associations.</div></div><div><h3>Main results</h3><div>Logistic regression modeling revealed that frailty was associated with major POCs (adjusted odds ratio [aOR], 95 % confidence interval [CI]: 2.61, 1.47–4.62). Each 1-point increase in frailty was associated with a 35 % increase in the risk of major POCs (aOR, 95 % CI: 1.35, 1.10–1.66). Slow walking speed, low physical activity and frequent exhaustion were independently associated with major POCs. Their ORs (95 % CI): 2.34 (1.33–4.13), 1.98 (1.09–3.57), 2.26 (1.28–3.99). Adding frailty to baseline risk model improved the predictive value of major POCs (NRI: 0.5551, 0.3095–0.8006; IDI: 0.0144, 0.0003–0.0286). Subgroup analyses revealed the same trend between frailty and major POCs.</div></div><div><h3>Conclusions</h3><div>Frail elderly patients scheduled for elective surgery were at an increased risk of major POCs, especially those with slow walking speed, low levels of physical activity, and frequent feelings of exhaustion.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112099"},"PeriodicalIF":5.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The neurocardiac axis in acute intracranial stress 急性颅内应激的神经心脏轴。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-17 DOI: 10.1016/j.jclinane.2025.112105
Wesley L. Allen , Kiran S. Merchant , Archer K. Martin, Shaun E. Gruenbaum, Benjamin F. Gruenbaum
Acute intracranial injuries including subarachnoid hemorrhage, traumatic brain injury, stroke, and seizures often trigger cardiovascular and pulmonary complications through the neurocardiac axis. This bidirectional connection between the brain and the heart is mediated by sympathetic overactivity, catecholamine excess, autonomic imbalance, and systemic inflammation. This narrative review synthesizes current evidence published between 1968 and 2025, identified through a comprehensive literature search. Representative studies were selected to provide an integrative overview of neurocardiac complications in acute neurologic injury, focusing on underlying mechanisms, clinical manifestations, diagnostic challenges, and management strategies. We describe the mechanisms underlying neurogenic stunned myocardium and Takotsubo syndrome, highlighting regional vulnerability based on autonomic innervation. Electrocardiographic features, cardiac biomarkers, and echocardiographic findings are discussed in the context of early recognition and risk stratification. We further examine diagnostic challenges, the importance of distinguishing neurologic from primary cardiac pathology, and therapeutic approaches including autonomic modulation and cardiopulmonary protective strategies. Understanding the unique pathogenesis of these syndromes can help guide individualized treatment strategies and anesthetic management to improve outcomes in patients with acute neurologic injury. By consolidating multidisciplinary insights, this review aims to enhance recognition and management of neurocardiac complications in this population.
急性颅内损伤,包括蛛网膜下腔出血、外伤性脑损伤、中风和癫痫发作,常通过神经心脏轴引发心血管和肺部并发症。这种大脑和心脏之间的双向连接是由交感神经过度活跃、儿茶酚胺过量、自主神经失衡和全身炎症介导的。这篇叙述性综述综合了1968年至2025年间发表的现有证据,通过全面的文献检索确定。我们选择了有代表性的研究来提供急性神经损伤的神经心脏并发症的综合概述,重点是潜在的机制、临床表现、诊断挑战和管理策略。我们描述了神经源性休克心肌和Takotsubo综合征的机制,强调了基于自主神经支配的区域易感性。在早期识别和风险分层的背景下,讨论了心电图特征、心脏生物标志物和超声心动图的发现。我们进一步研究了诊断挑战,区分神经系统和原发性心脏病理的重要性,以及包括自主神经调节和心肺保护策略在内的治疗方法。了解这些综合征的独特发病机制有助于指导个体化治疗策略和麻醉管理,以改善急性神经损伤患者的预后。通过整合多学科的见解,本综述旨在提高这一人群对神经心脏并发症的认识和管理。
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引用次数: 0
Preoperative cannabinoid exposure and postoperative pain: A narrative review 术前大麻素暴露和术后疼痛:叙述回顾。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-16 DOI: 10.1016/j.jclinane.2025.112097
Daniel D. King , Rhea Temmermand , Jennifer E. Greenwood

Background

Cannabis use is increasingly common, yet its effects on postoperative pain and opioid requirements remain unclear. While cannabinoids are used in chronic pain, their role in acute perioperative recovery is less defined.

Methods

A systematic search of PubMed, CINAHL, and Embase identified studies published within the past ten years that examined preoperative cannabis use and its relationship with postoperative pain and opioid consumption. Forty-two studies met the inclusion criteria. Data were extracted and summarized using a narrative synthesis methodology.

Results

Exposure definitions, surgical specialties, and outcome metrics were heterogeneous, limiting cross-study comparability; therefore, effects were reported in their native form without pooling. Of the 42 included studies, 14 (33.3 %) found that cannabis users reported higher postoperative pain, 10 (23.8 %) reported no difference, 2 (4.8 %) suggested reduced pain, and 16 (38.1 %) did not report pain outcomes. Regarding opioids, 18 studies (42.9 %) indicated greater postoperative requirements, 17 (40.5 %) found no difference, 3 (7.1 %) suggested reduced use, and 4 (9.5 %) did not report opioid outcomes. Specialty-specific patterns emerged: mixed cohorts (90 %) and spine populations (55 %) more frequently reported increased opioid use, whereas arthroplasty studies more often reported no difference (62 %). Limited, low-certainty evidence suggested that resuming cannabis after discharge was associated with lower persistent opioid use.

Conclusions

Preoperative cannabis exposure is associated with increased postoperative pain and opioid requirements in some, but not all, surgical contexts. Outcomes vary by specialty, and residual confounding and nonstandardized exposure measurement constrain inference, underscoring the need for standardized exposure definitions, prospective designs, and individualized perioperative pain strategies.
背景:大麻的使用越来越普遍,但其对术后疼痛和阿片类药物需求的影响尚不清楚。虽然大麻素用于慢性疼痛,但其在急性围手术期恢复中的作用尚不明确。方法:对PubMed、CINAHL和Embase进行系统检索,确定了过去十年发表的关于术前大麻使用及其与术后疼痛和阿片类药物消耗关系的研究。42项研究符合纳入标准。使用叙事综合方法提取和总结数据。结果:暴露定义、外科专科和结局指标存在异质性,限制了交叉研究的可比性;因此,在没有池化的情况下,以其原始形式报道了效应。在纳入的42项研究中,14项(33.3%)发现大麻使用者报告了更高的术后疼痛,10项(23.8%)报告没有差异,2项(4.8%)建议减轻疼痛,16项(38.1%)没有报告疼痛结果。关于阿片类药物,18项研究(42.9%)表明术后需要更多的阿片类药物,17项(40.5%)发现没有差异,3项(7.1%)建议减少使用,4项(9.5%)没有报告阿片类药物的结果。出现了特殊的模式:混合队列(90%)和脊柱人群(55%)更频繁地报告阿片类药物使用增加,而关节置换术研究更频繁地报告没有差异(62%)。有限的、低确定性的证据表明,出院后恢复使用大麻与持续使用阿片类药物的减少有关。结论:术前大麻暴露与术后疼痛和阿片类药物需求增加有关,但不是所有的手术情况。结果因专科而异,残留混淆和非标准化暴露测量限制了推断,强调了标准化暴露定义、前瞻性设计和个体化围手术期疼痛策略的必要性。
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引用次数: 0
Extracting intraoperative blood loss from unstructured clinical narratives 从非结构化临床叙述中提取术中出血量。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-15 DOI: 10.1016/j.jclinane.2025.112101
Anne B. Alnor , Rasmus B. Lynggaard , Lina E. Pedersen , Jonas Storgaard , Martin S. Laursen , Pernille J. Vinholt
{"title":"Extracting intraoperative blood loss from unstructured clinical narratives","authors":"Anne B. Alnor ,&nbsp;Rasmus B. Lynggaard ,&nbsp;Lina E. Pedersen ,&nbsp;Jonas Storgaard ,&nbsp;Martin S. Laursen ,&nbsp;Pernille J. Vinholt","doi":"10.1016/j.jclinane.2025.112101","DOIUrl":"10.1016/j.jclinane.2025.112101","url":null,"abstract":"","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"109 ","pages":"Article 112101"},"PeriodicalIF":5.1,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative SGLT2i therapy and acute kidney injury in patients undergoing emergency and urgent coronary artery bypass grafting - A causal inference framework 急诊和紧急冠状动脉旁路移植术患者术前SGLT2i治疗与急性肾损伤的因果推断框架
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-15 DOI: 10.1016/j.jclinane.2025.112103
Michael Kolland , Selina Sartori , Christoph Klivinyi , Michael Schörghuber , Jakob Pannold , Igor Knez , Alexander H. Kirsch , Nikolaus Schreiber

Background

Acute kidney injury (AKI) is a common complication after coronary artery bypass grafting (CABG), associated with adverse short- and long-term outcomes. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce occurrence of AKI in several populations, yet their perioperative effects in patients undergoing CABG are unknown.

Methods

We conducted a retrospective study at the Department of Cardiac Surgery, Medical University of Graz (2020–2024) to evaluate the impact of preoperative SGLT2i use on cardiac surgery–associated AKI in adults undergoing urgent or emergent isolated coronary artery bypass grafting in patients with an indication for SGLT2i therapy (type 2 diabetes mellitus, heart failure with reduced ejection fraction, or chronic kidney disease). Patients with preoperative dialysis, sepsis, reoperation, mechanical circulatory support or missing laboratory data were excluded. Exposure was defined as SGLT2i use within two weeks before surgery, and the primary outcome was cardiac surgery-associated AKI (CSA-AKI) according to KDIGO criteria. Secondary outcomes included kidney replacement therapy, ICU length of stay, 30-day mortality and postoperative diabetic ketoacidosis. Causal effects were estimated using entropy balancing. Results were reported as weighted risk differences, risk ratios, and adjusted mean differences, with time-to-event outcomes analyzed via weighted Cox models and Kaplan–Meier estimates.

Results

Among 484 patients, 135 were on SGLT2i. CSA-AKI occurred in 23.0 % of SGLT2i users vs. 28.1 % of non-users (risk ratio of 0.63 [95 % CI 0.44–0.91; p = 0.014]). The association was pronounced in patients with heart failure with reduced ejection fraction and those with high EuroSCORE II. No differences were observed in other secondary endpoints and no cases of postoperative diabetic ketoacidosis occurred.

Conclusion

Preoperative SGLT2i use was associated with a significantly lower risk of CSA-AKI in patients undergoing urgent or emergent CABG. These findings need to be confirmed in prospective multicenter trials but underline the favorable safety profile of this medication.
背景:急性肾损伤(AKI)是冠状动脉旁路移植术(CABG)后常见的并发症,与不良的短期和长期预后相关。钠-葡萄糖共转运蛋白-2抑制剂(SGLT2i)已被证明可以减少几个人群AKI的发生,但其在CABG患者的围手术期效果尚不清楚。方法:我们在格拉茨医科大学心脏外科(2020-2024)进行了一项回顾性研究,以评估术前使用SGLT2i对有SGLT2i治疗指征(2型糖尿病、心力衰竭伴射血分数降低或慢性肾病)的成人紧急或紧急孤立冠状动脉旁路移植术中心脏手术相关AKI的影响。排除术前透析、败血症、再手术、机械循环支持或缺少实验室数据的患者。暴露被定义为术前两周内使用SGLT2i,根据KDIGO标准,主要结局是心脏手术相关AKI (CSA-AKI)。次要结局包括肾脏替代治疗、ICU住院时间、30天死亡率和术后糖尿病酮症酸中毒。利用熵平衡估计因果效应。结果报告为加权风险差异、风险比和调整后的平均差异,并通过加权Cox模型和Kaplan-Meier估计分析事件发生时间。结果:484例患者中,有135例接受SGLT2i治疗。SGLT2i使用者中CSA-AKI发生率为23.0%,非使用者中为28.1%(风险比为0.63 [95% CI 0.44-0.91; p = 0.014])。在射血分数降低的心力衰竭患者和EuroSCORE II高的患者中,这种关联明显。其他次要终点无差异,术后无糖尿病酮症酸中毒病例发生。结论:术前使用SGLT2i与急诊或紧急冠脉搭桥患者CSA-AKI风险显著降低相关。这些发现需要在前瞻性多中心试验中得到证实,但强调了该药物的良好安全性。
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引用次数: 0
Beyond the operating room: Holistic support for frail surgical patients. 超越手术室:为身体虚弱的外科病人提供全面的支持。
IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Pub Date : 2025-12-15 DOI: 10.1016/j.jclinane.2025.112095
Aubrey Samost-Williams, Alparslan Turan, Victoria Tang
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引用次数: 0
期刊
Journal of Clinical Anesthesia
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