We herein report a case of allergic contact dermatitis (ACD) caused by Dermabond® Advanced, which was diagnosed by a patch test using SurgiSeal® (Nitcho Kogyo, Tokyo, Japan) as a control. A difference in the temperature increase at the time of application suggested that temperature may be a risk factor for sensitization.
While combined use of BRAF/MEK inhibitors has elicited dramatic clinical efficacy in incurable melanoma, drug-associated retinopathy has become an emerging adverse event. We present two Japanese men with advanced melanoma who developed visual impairment due to serous retinal detachments (SRDs) with cystoid macular edema (CME) immediately after initial administration of encorafenib/binimetinib, a BRAF and MEK inhibitor. One case had drug-intolerable retinopathy on repeat dosing. Both cases were switched to another BRAF/MEK inhibitors, dabrafenib/trametinib, with no recurrence of SRDs. Co-existing CME may be a confounding risk for the early development of SRDs with encorafenib/binimetinib therapy, providing attention during drug administration.
We report a case of rheumatoid arthritis who developed cutaneous diffuse large B-cell lymphoma during methotrexate (MTX) monotherapy with prompt resolution after discontinuation of the drug. Our literature review of over 100 reported Japanese cases revisited the potential risk of treatment resistance and/or repeated recurrence of lymphomas, particularly in cases that were unresponsive to the withdrawal of MTX or received a higher cumulative dose.
We have experienced a case of SWSL involving significant gastrointestinal erosion that occurred after TMP-SMX medication. For accurate diagnosis and prompt treatment of complications, it is essential to be aware of the possibility of this phenomenon.
Psoriasis is a chronic skin inflammatory disease characterized by epidermal proliferation and inflammatory cell infiltration. AXL is a tyrosine kinase receptor that promotes cell proliferation and invasion in cancer cells, and its expression is elevated in multiple tumors. However, less is known about its expression and function in inflammatory diseases.
The aim of this study is to examine AXL expression in psoriasis and investigate the biological function of AXL under psoriatic conditions.
AXL mRNA expression was decreased in psoriatic skin compared to healthy skin, and an inverse correlation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio was observed. Immunohistochemical staining of psoriatic skin revealed decreased AXL expression of the epidermis and an increased number of AXL-positive dendritic cells in the dermis. Stimulation of epidermal keratinocytes with antimicrobial peptide LL37, but not with IL-17A, resulted in decreased AXL expression. Knockdown of AXL in epidermal keratinocytes did not affect cell proliferation or expression of psoriasis-associated cytokines and chemokines.
Decreased epidermal AXL expression and increased infiltration of AXL-expressing dendritic cells were revealed in psoriasis.
An 81-year-old Japanese man presented with a history of recurrent eyelid swelling and purpura on the face, neck, and limbs. Because the initial clinical presentation was angioedema alone, the patient was treated with an H1-receptor antagonist and tranexamic acid as for an idiopathic angioedema. The patient also experienced dyspnea simultaneously with edema on the face and limbs and was thus taken to the emergency room, where laryngeal edema was confirmed on laryngeal fiber. A good response to hydrocortisone injection was observed in the patient. ACE inhibitors were never prescribed for the patient, and there was no family history of angioedema. Laboratory data indicated normocomplementemia, and skin biopsies revealed leukocytoclastic vasculitis. Therefore, the patient was diagnosed with NUV. Following hospitalization, the patient experienced appetite loss and the CRP level increased, presenting with thickening and stranding around colon tissues on abdominal CT. These symptoms responded well to prednisone treatment. Given that the initial clinical manifestation of the current case was mainly angioedema, physicians should consider that angioedema may in rare cases be diagnostic for UV.
The case of a widespread erythematous drug eruption brought on by favipiravir is described here. Patch tests and the drug lymphocyte transformation test (LTT) both indicated a positive reaction. Since COVID-19 patients take many medications, the potential for a drug eruption must be taken into account when diagnosing a rash.
We present a case of Generalized pustular psoriasis (GPP) presented with SARS-CoV-2 infection under the control of secukinumab. Mutation analysis revealed a heterogeneous c.28C>T (p.Arg10X) mutation in IL36RN. Mutation analysis should be considered to enable preparation for biologic therapy to treat intractable flare-ups.
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