Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.S6.E001
Martinx Martinez Sobrer
{"title":"Ribosomes: Atomic Machines Association between Nucleic acids and Proteins","authors":"Martinx Martinez Sobrer","doi":"10.35248/2153-0602.21.S6.E001","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S6.E001","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"141 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73974575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.12.E133
W. Rodney
When retroviruses have integrated their very own genome into the germ line, their genome is passed directly to a following technology. These endogenous retroviruses (ERVs), contrasted with exogenous ones, now make up five–eight% of the human genome. most insertions have no recognized function and are regularly called "junk DNA". However, many endogenous retroviruses play crucial roles in host biology, which includes control of gene transcription, cellular fusion at some stage in placental development inside the direction of the germination of an embryo
{"title":"Retroviruses Integrated their Own Genome into the Germ Line","authors":"W. Rodney","doi":"10.35248/2153-0602.21.12.E133","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.E133","url":null,"abstract":"When retroviruses have integrated their very own genome into the germ line, their genome is passed directly to a following technology. These endogenous retroviruses (ERVs), contrasted with exogenous ones, now make up five–eight% of the human genome. most insertions have no recognized function and are regularly called \"junk DNA\". However, many endogenous retroviruses play crucial roles in host biology, which includes control of gene transcription, cellular fusion at some stage in placental development inside the direction of the germination of an embryo","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"31 1","pages":"0-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74792061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.12.243
Dragovich Branko
Chromosome breakage is one of the more significant results of ionizing radiation openness of cells, and, to be sure, ionizing radiation is best in creating this class of underlying change. Another chromosome deformity, other than breakage, that is significant in hereditary illnesses, however that is irrelevant because of radiation harm, is maldistribution of chromosomes, to such an extent that little girl cells have a mistaken supplement of unblemished chromosomes. Since this last change is by and large not a significant result of radiation openness, no more will be said. Chromosome breakage can happen before replication of the DNA of the cell, in which occasion, at replication the underlying imperfection will likewise be repeated (or it will come up short in endeavored replication), and the deformity will be found in the metaphase chromosome in the two chromatids. At the point when breakage happens after DNA replication, the harm will for the most part be viewed as an unbalanced change in one of the two chromatids. As a populace of separating cells is presented to ionizing radiation, the cells are in all potential phases of movement through the cell cycle. Contingent upon the area of the influenced cell in the cycle, three distinct sorts of chromosome variations that outcome from chromosome breakage can be found. Every one of these will be seen in the metaphase chromosome cluster as that part of the cell populace advances forward through the cell cycle to mitosis. Time from the illumination occasion to the assortment of mitoses will decide the situation of the cell cycle that is noticed. For instance, for a given cell line, when the length of the S time frame is, say 6 hours and the length of G2M is 60 minutes, at that point assortment of mitoses at 7 hours after light will give admittance to changes that happened as the consequence of the illumination of cells that were nearly entering the S time frame at the hour of light. The cells gathered at 7 hours after illumination will possess had the entirety of this energy for fix or potentially compensation of DNA.
{"title":"Chromosome Breakage before Replication of the DNA","authors":"Dragovich Branko","doi":"10.35248/2153-0602.21.12.243","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.243","url":null,"abstract":"Chromosome breakage is one of the more significant results of ionizing radiation openness of cells, and, to be sure, ionizing radiation is best in creating this class of underlying change. Another chromosome deformity, other than breakage, that is significant in hereditary illnesses, however that is irrelevant because of radiation harm, is maldistribution of chromosomes, to such an extent that little girl cells have a mistaken supplement of unblemished chromosomes. Since this last change is by and large not a significant result of radiation openness, no more will be said. Chromosome breakage can happen before replication of the DNA of the cell, in which occasion, at replication the underlying imperfection will likewise be repeated (or it will come up short in endeavored replication), and the deformity will be found in the metaphase chromosome in the two chromatids. At the point when breakage happens after DNA replication, the harm will for the most part be viewed as an unbalanced change in one of the two chromatids. As a populace of separating cells is presented to ionizing radiation, the cells are in all potential phases of movement through the cell cycle. Contingent upon the area of the influenced cell in the cycle, three distinct sorts of chromosome variations that outcome from chromosome breakage can be found. Every one of these will be seen in the metaphase chromosome cluster as that part of the cell populace advances forward through the cell cycle to mitosis. Time from the illumination occasion to the assortment of mitoses will decide the situation of the cell cycle that is noticed. For instance, for a given cell line, when the length of the S time frame is, say 6 hours and the length of G2M is 60 minutes, at that point assortment of mitoses at 7 hours after light will give admittance to changes that happened as the consequence of the illumination of cells that were nearly entering the S time frame at the hour of light. The cells gathered at 7 hours after illumination will possess had the entirety of this energy for fix or potentially compensation of DNA.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"13 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83868868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.S6.002
V. Murugan
{"title":"Nucleic Genome: A Sort of Microbial Complete Genome Annotation Database","authors":"V. Murugan","doi":"10.35248/2153-0602.21.S6.002","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S6.002","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"12 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75625815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.S6.E002
Martinx Martinez Sobrer
{"title":"Mitochondrial Inheritance in Most Multicellular Life Forms","authors":"Martinx Martinez Sobrer","doi":"10.35248/2153-0602.21.S6.E002","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S6.E002","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"150 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75934281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.12.237
Nathan Basisty, B. Schilling
Mass Spectrometry-based protein turnover studies have shed light on the remarkable relationship between protein turnover and longevity. Here, we discuss the potential implications of the strong correlation between protein longevity (longer soluble protein half-lives) and longer mammalian lifespan, and conversely, the accumulation old insoluble proteins with age. We propose several strategies that can be employed in future studies to address the interesting questions raised by these observations-which protein half-life best correlate with longevity? Is protein half- live a biomarker for interventions that extend lifespan? How do post-translational modifications affect protein turnover?
{"title":"A Need for Proteomics: Untangling the Relationship between Protein Turnover, Aging, and Longevity","authors":"Nathan Basisty, B. Schilling","doi":"10.35248/2153-0602.21.12.237","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.237","url":null,"abstract":"Mass Spectrometry-based protein turnover studies have shed light on the remarkable relationship between protein turnover and longevity. Here, we discuss the potential implications of the strong correlation between protein longevity (longer soluble protein half-lives) and longer mammalian lifespan, and conversely, the accumulation old insoluble proteins with age. We propose several strategies that can be employed in future studies to address the interesting questions raised by these observations-which protein half-life best correlate with longevity? Is protein half- live a biomarker for interventions that extend lifespan? How do post-translational modifications affect protein turnover?","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"6 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88595565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.12.238
F. Hoff, Ti’ara L. Griffen, A. Dijk, S. Kornblau
Acute Myeloid Leukemia (AML) is a hematological malignancy with poor survival outcomes in children and adults. There is a need to enhance AML patient risk stratification to improve clinical outcomes. Precision medicine approaches that focus on the identification of patient-specific biomarkers are currently in development to improve diagnostics and treatment of cancer. Here, we comment on our studies showing the clinical significance of histone and chromatin modifier proteins in AML. Using proteomics, we identified novel subsets of adult AML patients with epigenetically distinct protein profiles that have clinical impact. More recently we discovered that overexpression of similar proteins also seems to predict poor prognosis in pediatric AML, as well as that epigenetic proteins form prognostic clusters in chronic lymphocytic leukemia. In this commentary we focus on how we can improve precision medicine in leukemia by targeting the epigenetic landscape based on proteomics in clinical practice.
{"title":"Short Communication on Histone Modification Patterns using RPPA?Based Profiling Predict Outcome in Acute Myeloid Leukemia Patients","authors":"F. Hoff, Ti’ara L. Griffen, A. Dijk, S. Kornblau","doi":"10.35248/2153-0602.21.12.238","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.238","url":null,"abstract":"Acute Myeloid Leukemia (AML) is a hematological malignancy with poor survival outcomes in children and adults. There is a need to enhance AML patient risk stratification to improve clinical outcomes. Precision medicine approaches that focus on the identification of patient-specific biomarkers are currently in development to improve diagnostics and treatment of cancer. Here, we comment on our studies showing the clinical significance of histone and chromatin modifier proteins in AML. Using proteomics, we identified novel subsets of adult AML patients with epigenetically distinct protein profiles that have clinical impact. More recently we discovered that overexpression of similar proteins also seems to predict poor prognosis in pediatric AML, as well as that epigenetic proteins form prognostic clusters in chronic lymphocytic leukemia. In this commentary we focus on how we can improve precision medicine in leukemia by targeting the epigenetic landscape based on proteomics in clinical practice.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"68 6 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87650657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.12.239
J. Watson
Data mining is also known as the knowledge discovery data, which collects powerful and useful information from the large data and it is useful in future trends. The spontaneous of using large data from the discovered trends and the ways lead to the usage of simple research. Data mining enlightened the algorithms of mathematical studies to components of the data and calculates the possibility of future events.
{"title":"Fundamentals of Data Mining and its Importance","authors":"J. Watson","doi":"10.35248/2153-0602.21.12.239","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.239","url":null,"abstract":"Data mining is also known as the knowledge discovery data, which collects powerful and useful information from the large data and it is useful in future trends. The spontaneous of using large data from the discovered trends and the ways lead to the usage of simple research. Data mining enlightened the algorithms of mathematical studies to components of the data and calculates the possibility of future events.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"22 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76609764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.S6.001
V. Murugan
{"title":"Nucleic Corrosive Thermodynamics by Polymerase Proteins","authors":"V. Murugan","doi":"10.35248/2153-0602.21.S6.001","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S6.001","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"21 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81655814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2153-0602.21.12.233
Carlos J. Ramrez-Flores, Ricardo Mondragn-Flores
Toxoplasma gondii is one of the most successful pathogens worldwide. Its high secretory capability is related to its dynamics for motility, invasion and tissue dissemination within the infected host. Toxoplasma is a highly secretory parasite of proteins released from secretory organelles such as micronemes, rhoptries and dense granules, but it also secretes/excretes a huge variety of extracellular vesicles with unknown role. Herein, it is discussed some characteristics of the extracellular vesicles released by Toxoplasma, such as their different sizes, different identification names, and their possible biological functions
{"title":"Elucidating the Role of Extracellular Vesicles Released by Toxoplasma gondii: A Review","authors":"Carlos J. Ramrez-Flores, Ricardo Mondragn-Flores","doi":"10.35248/2153-0602.21.12.233","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.233","url":null,"abstract":"Toxoplasma gondii is one of the most successful pathogens worldwide. Its high secretory capability is related to its dynamics for motility, invasion and tissue dissemination within the infected host. Toxoplasma is a highly secretory parasite of proteins released from secretory organelles such as micronemes, rhoptries and dense granules, but it also secretes/excretes a huge variety of extracellular vesicles with unknown role. Herein, it is discussed some characteristics of the extracellular vesicles released by Toxoplasma, such as their different sizes, different identification names, and their possible biological functions","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"51 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82288563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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