Journal of Exercise Rehabilitation最新文献

Aging is associated with a progressive decline in both cognitive and physical function, and neuroinflammation and metabolic dysregulation often exacerbate this decline, particularly in older women. This study investigated the effects of a 12-week intermittent combined exercise program on cognitive function, physical performance, and neurophysiological biomarkers in community-dwelling women aged 75 years and older. Forty participants were recruited from a local welfare center and randomly assigned to an exercise group (n=20) or a control group (n=20). The exercise group participated in three supervised sessions per week that integrated aerobic exercise, resistance exercise, functional exercise, and cognitive exercise. Cognitive domains (attention, language, and memory) were assessed using the Seoul Neuropsychological Screening Test-II. Physical function was assessed using the Geriatric Physical Fitness Test (chair stand, arm flexion, grip strength, and 6-min walk). Blood samples were analyzed to measure serum brain-derived neurotrophic factor (BDNF), interleukin (IL-6), tumor necrosis factor (TNF)-α, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Paired and independent t-tests were performed to evaluate pre- and posttest differences (α=0.05). After 12 weeks, the exercise group significantly improved memory (P<0.05), lower upper-body muscle strength, grip strength, and walking endurance. Serum BDNF significantly increased (P<0.01), and IL-6, TNF-α, LDL-C, and TG decreased (P<0.05). HDL-C levels also significantly increased (P<0.05). Intermittent combined exercise significantly improved cognitive and physical function and favorably modulated neurotrophic, inflammatory, and metabolic biomarkers in very elderly women.

This study investigated the effects of 4-week and 8-week moderate-intensity aerobic exercise on body composition and markers of inflammation and oxidative stress in middle-aged obese Hispanic females, with a particular focus on assessing these changes independently of fat mass reduction. A total of 35 participants were randomly assigned to either an exercise group or a control group for an eight-week intervention. The exercise group performed treadmill-based aerobic training at 55% of maximal oxygen consumption, with a fixed workload adjusted for body mass and a progression from three to four weekly sessions. Body composition was assessed using dual-energy x-ray absorptiometry, and blood samples were collected at baseline, 4 weeks, and 8 weeks to analyze tumor necrosis factor-alpha (TNF-α), C-reactive protein, adiponectin, total antioxidant status (TAS), and 8-hydroxydeoxyguanosine (8-OHdG). After 8 weeks, the exercise group showed significant reductions in body fat percentage, TNF-α, and 8-OHdG, alongside an increase in TAS. Notably, by week 4, significant decreases in TNF-α and increases in TAS were observed despite no measurable changes in body weight or fat mass, indicating an early anti-inflammatory and antioxidative response to exercise independent of adiposity reduction. The findings at 4 weeks suggest that moderate aerobic exercise can independently reduce inflammation and oxidative stress, even before measurable fat loss occurs. These improvements were further enhanced by fat loss after 8 weeks, indicating that moderate aerobic exercise may reduce the risk of obesity-related disorders in middle-aged obese females, both through direct anti-inflammatory effects and by promoting fat loss.

This study examined the process of forest hiking (FH) through skeletal muscle oxygen saturation (SmO₂) and investigated subsequent changes in muscle function, erythrocytes, and immunocytes. A total of 60 participants who their ages, heights, and weights of 73.05±3.23 years, 1.63±0.06 m, and 67.75±9.22 kg. They resided in two living communities, and were assigned to the control (CON, n=30) group, whereas those from the other were allocated to the FH (n=30) group. The intervention consisted of a hiking program performed for 120 min per day, twice per week, over a 4-week period. The degree of oxygen utilization in muscles during the hiking was monitored by measuring SmO₂ in the vastus lateralis (VL). During hiking, SmO₂ levels in the FH group progressively declined, reaching a nadir between 60 and 90 min, followed by partial recovery. After the intervention, the FH group showed pronounced improvements in contraction time in the VL than in the biceps femoris (BF), while maximum displacement improved in both the VL and BF (P<0.05). Among erythrocytes parameters, significant interaction effects were observed for hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin concentration (P<0.05). In addition, significant interaction effects were found in immunocytes (P<0.01). This study demonstrated that SmO₂ can be effectively measured during FH and confirmed that a 4-week hiking induced marked improvements not only in muscle function but also in erythrocytes and immunocytes in older adults.

This systematic literature review analyzes domestic studies on pulmonary rehabilitation nursing interventions for patients with chronic obstructive pulmonary disease (COPD) published in the field of rehabilitation nursing over the past decade. This analysis will inform the restructuring of pulmonary rehabilitation nursing and suggest future research directions. The systematic literature review analyzed 12 domestic studies on pulmonary rehabilitation nursing interventions for patients with COPD. Previous studies have suggested that combined interventions are more effective than single interventions, despite differences in the study populations. Interventions combining exercise and education showed the most significant improvements in self-care behaviors, respiratory function, and anxiety. Self-care is the process of maintaining health through health promotion and disease management, regardless of whether the condition is stable or worsening. Therefore, establishing effective self-care in pulmonary rehabilitation requires evidence-based education, individualized interventions, multidisciplinary collaboration, and continuous monitoring with feedback. Effective disease management in COPD patients requires a thorough understanding of their condition and practical behavioral strategies.

This study aimed to investigate the effects of 12 weeks of plyometric training on body composition, physical fitness, and bone mineral density (BMD) in obese male adolescents. Twenty obese male adolescents were randomly assigned to a control group (n=10) or a plyometric exercise group (n=10). The plyometric exercise group performed the exercise 3 times a week for 12 weeks. Body composition, physical fitness, and BMD were measured before and after the 12-week intervention. Following results were obtained. In the plyometric exercise group, body fat mass significantly decreased before and after the intervention, but differences in body weight, body mass index, and lean body mass were not significant. Among physical fitness factors, grip strength, muscular endurance, and the 20-m shuttle run significantly improved, but flexibility did not show a significant difference. In the plyometric exercise group, BMD significantly improved before and after the intervention. These results indicate that 12 weeks of plyometric training may be effective in improving body composition, physical fitness, and bone density in obese adolescents.

Hepatocellular carcinoma (HCC) is a prevalent cancer with high mortality rates globally. This review explores various HCC treatments, including surgical resection, liver transplantation, local ablation, and systemic therapies. With advancements in surgical techniques, local therapies, and immunotherapy, the treatment paradigm for HCC is rapidly evolving. Surgical resection remains the preferred first-line treatment for localized HCC with preserved liver function, offering significant survival benefits. Liver transplantation is suitable for patients meeting specific criteria and helps restore liver function in individuals with compromised liver capabilities, providing excellent long-term outcomes. Local ablation is recommended for very early-stage HCC ineligible for surgery, offering outcomes comparable to resection. Transarterial therapies, such as transarterial radioembolization, are employed to treat intermediate-stage HCC, enhancing treatment outcomes. Radiation therapy is increasingly utilized due to improved safety profiles, providing effective treatment options for HCC patients. Systemic treatments have advanced with the introduction of molecularly targeted therapies and immune checkpoint inhibitors, improving survival rates. The development of immunotherapy combinations has shown promising efficacy as first-line treatments. The ongoing advancement in treatment strategies, alongside personalized patient approaches, is expected to further enhance outcomes for HCC patients.