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Improvement on BAF53B Mutation Caused Developmental and Epileptic Encephalopathy with a Ketogenic Diet 生酮饮食改善BAF53B突变引起的发育性和癫痫性脑病
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-110000118
Danli Wang, Linlin Fan, Haoying Yang, Mingming Pan, Junping Shi, Ang Li, Nini Wang, Xue Xia, Yang Liu
Purpose: Genetic mutation is the leading cause of Developmental and Epileptic Encephalopathy (DEE, OMIM 308350), a spectrum of disorders characterized by severe epilepsy and usually begins in infancy, accompanied with psychomotor development arrest and hypsarrhythmiaon electroencephalogram (EEG).Up till now, mutations of 101 genes were confirmed as the cause of DEE, and were categorized accordingly into 101 different sub-types (DEE1-101). Here, we report a case of DEE76 with a tortuous path to genetic diagnosis and an illuminating treatment of ketogenic diet (KD). Methods: Through high throughput sequencing, we identified a DEE76 case caused by biallelic BAF53B mutation inherited in an autosomal recessive manner, and report the pathogenic variants NM_016188.4:c.892C>T (p.Arg298*) and NM_016188.4:c.991_996delinsAA (p.Gly331Asnfs*44) for the first time. Results: The proband commenced seizures on day five after birth and rapidly deteriorated during development. After a series of therapeutic exploration, ketogenic diet turned out to be the most hopeful treatment available. Conclusion: ultra-rare gene therapy KD, seizures
目的:基因突变是发育性和癫痫性脑病(DEE, OMIM 308350)的主要原因。发育性和癫痫性脑病是一种以严重癫痫为特征的疾病,通常始于婴儿期,伴有精神运动发育停止和低心律失常脑电图(EEG)。到目前为止,有101个基因突变被确认为DEE的病因,并据此分为101个不同的亚型(DEE1-101)。在这里,我们报告一个病例DEE76曲折的路径遗传诊断和启发性的治疗生酮饮食(KD)。方法:通过高通量测序,鉴定1例由常染色体隐性遗传的双等位基因BAF53B突变引起的DEE76病例,并报道致病变异NM_016188.4:c。c. 892C>T (p.Arg298*)和NM_016188.4;991_996delinsAA (p.Gly331Asnfs*44)。结果:先证者在出生后第5天开始癫痫发作,在发育过程中病情迅速恶化。经过一系列的治疗探索,生酮饮食被证明是最有希望的治疗方法。结论:超罕见基因治疗KD,癫痫发作
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引用次数: 0
Coronasomnia: A Hidden Problem of the COVID era. Is Melatonin a Potential Solution? 冠状肺炎:新冠时代隐藏的问题。褪黑素是一个潜在的解决方案吗?
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-11000084
R. Supriya, Kumar Purnendu Singh, F. Dutheil, Yaodong Gu, Julien S Baker
Globally, changes in work cultures have impacted on all life, and individuals have reported increased insomnia “Coronasomnia” as a result of COVID-19. Correct nutrition, in relation to micronutrient concentration, may have beneficial effects in controlling our biological sleep clocks. Specifically, melatonin supplementaions are being recommended for the COVID generation. However, there have been J Food Sci Nutr Res 2022; 5 (1): 325-340 DOI: 10.26502/jfsnr.2642-11000084 Journal of Food Science and Nutrition Research Vol. 5 No. 1 March 2022. [ISSN 2642-1100] 326 mixed reports regarding melatonin supplementation using high dosages for certain population groups, and there may be disadvantages in using melatonin as an exogenous supplement (oral tablet or injectable drug) in the long term. As a result, melatonin may not be suitable for all post COVID generations without further clinical trials. However, melatonin as a dietary supplement could have significant health benefits without causing any adverse effects. Therefore, the main aim of this opinion article is to highlight the challenges of “Coronasomnia” related to COVID 19, which has been overlooked. In addition, we highlight the research need for clinical trials on melatonin supplementation for inclusion in the diets of the COVID generation. Supplementation regimes using naturally occurring melatonin obtained from dietary sources will regulate central biological cycle naturally. Consequently, future research is needed to investigate whether melatonin containing foods are clinically beneficial to the COVID generation by increasing the bioavailability of melatonin using dietary supplementation.
在全球范围内,工作文化的变化已经影响到所有人的生活,人们报告说,由于COVID-19,失眠症“冠状肺炎”有所增加。正确的营养,与微量营养素浓度有关,可能对控制我们的生物钟有有益的影响。具体来说,建议为新冠一代补充褪黑激素。然而,有《J Food science nur Res 2022》;5 (1): 325-340 DOI: 10.26502/jfsnr。食品科学与营养研究Vol. 5 No. 1 March 2022。[ISSN 2642-1100] 326关于某些人群使用高剂量褪黑激素补充的混合报告,并且长期使用褪黑激素作为外源性补充(口服片剂或注射药物)可能存在缺点。因此,如果没有进一步的临床试验,褪黑激素可能不适合所有后COVID世代。然而,褪黑素作为一种膳食补充剂可能有显著的健康益处,而不会造成任何不良影响。因此,这篇评论文章的主要目的是强调与COVID - 19相关的“冠状肺炎”的挑战,这一点一直被忽视。此外,我们强调需要进行褪黑激素补充临床试验,以便将其纳入新冠一代的饮食中。使用从饮食中获得的天然褪黑激素的补充制度将自然地调节中央生物循环。因此,需要进一步研究含有褪黑激素的食物是否通过膳食补充提高褪黑激素的生物利用度,从而在临床上有利于新冠病毒的生成。
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引用次数: 2
Nutritional Status Pre-Gestational and Gestational Among Women Living With HIV Positive in Luanda, Angola 安哥拉罗安达艾滋病毒阳性妇女孕前和妊娠期营养状况
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-110000116
Maura Eunice João Filipe, M. Santana
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引用次数: 0
A Randomized Controlled Clinical Trial to Study the Impact of Multigrain Instant Health Drink Mix in Clinical Management of Anemia in Women 一项随机对照临床试验研究杂粮速溶保健饮料对妇女贫血临床管理的影响
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-11000091
V. Vaidya, G. Ganu, N. Naik, Murugan Narayanaswamy
A controlled clinical trial to study the impact of Multigrain Instant Health Mix in clinical management of anemia in women. Abstract Background WHO considers Iron Deficiency Anemia (IDA) as one of the most expensive diseases in the world due to lost productivity and the sheer numbers of the affected population. In 2019, global anemia prevalence was 29.9% (95% uncertainty interval (UI) 27.0%, 32.8%) in women of reproductive age, equivalent to over half a billion women aged 15-49 years. Prevalence was 29.6% (95% UI 26.6%, 32.5%) in non-pregnant women of reproductive age, and 36.5% (95% UI 34.0%, 39.1%) in pregnant women. consume warm milk twice a day and provided counselling for nutrition and anemia over 90 days. There was significant increase in hemoglobin levels (20.6%) in Health Drink Mix treated group compared to 2.76% in control group. The levels of serum iron were significantly increased in Health Drink Mix Group than control group (35.38%). Health Drink Mix led to reduction in symptoms such as weakness, pale and yellow skin, dysmenorrhea, lightheadedness. There was significant reduction in fatigue severity score in Health Drink Mix treated group than control. It can be concluded from the present study that Multigrain Instant Health Drink Mix is safe and efficacious in treatment of anemia in women. It can offer 360 degree improvement in anemia. It ensures improvement in Hb, Ferritin, Iron levels along with reduction in TIBC. The present research ensures consumers of this product to get the effectiveness to treat and manage the anemia and related complaints with no side effects related to iron supplementation.
一项对照临床试验,研究多种谷物即食保健混合物对妇女贫血临床管理的影响。世界卫生组织认为缺铁性贫血(IDA)是世界上最昂贵的疾病之一,原因是生产力损失和受影响人口的绝对数量。2019年,全球育龄妇女贫血患病率为29.9%(95%不确定区间为27.0%,32.8%),相当于5亿多名15-49岁的妇女。非妊娠育龄妇女患病率为29.6% (95% UI 26.6%, 32.5%),妊娠妇女患病率为36.5% (95% UI 34.0%, 39.1%)。每天喝两次热牛奶,并在90天内提供营养和贫血咨询。与对照组的2.76%相比,保健饮料混合治疗组的血红蛋白水平显著升高(20.6%)。保健饮料混合组血清铁水平显著高于对照组(35.38%)。健康饮品能减轻身体虚弱、皮肤苍白和发黄、痛经、头晕等症状。治疗组疲劳严重程度评分明显低于对照组。本研究表明,杂粮速溶保健饮料对治疗女性贫血安全有效。它可以360度改善贫血。它确保改善血红蛋白,铁蛋白,铁水平随着减少TIBC。目前的研究确保该产品的消费者获得治疗和管理贫血和相关投诉的有效性,并且没有与铁补充相关的副作用。
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引用次数: 0
Assessment of Nutritional Status and Associated Factors in Children Aged 6 to 59 Months in Ayos Locality, Cameroon 喀麦隆阿约斯地区6至59个月儿童营养状况及相关因素评估
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-110000110
Angèle Eveline Tchapda, Serge Berlin Dzeukou, Christine Fernande Biyegue Nyangono, Nicolas Policarpe Nolla, I. Gouado, E. Tetanye
Childhood malnutrition is a serious public health problem around the world, particularly in Cameroon. This study was conducted to assess nutritional status and associated factors for children aged 6 to 59 months in the locality of Ayos. This is a cross-sectional and descriptive study that took place from August to October 2019 on a random sample of 309 children and his mothers. Anthropometric parameters of children were measured, socio-demographic data of mothers and children's eating habits were collected using a questionnaire, association between socio-demographic factors, dietary practices and malnutrition were identified. The results showed that 9.06% of children were wasted with 3.56% in the severe form, 26.54% were underweight with 10.03% in the severe form and 53.07% were stunted with 34.96% in the severe form. Overall, 86.1% of mothers have a poor understanding of the concept of dietary diversity. The first complementary food introduced is the poorly enriched local porridge used by 40.52% of the mothers, followed by the family meal, used by 38.52% of them. Marital status (p=0.009), level of education (p=0.001), occupation (p=0.046) were associated with chronic malnutrition. Type of breastfeeding (p=0.005), age of introduction of complementary foods (p=0.004), reason for introduction (p=0.002) had a significant association on the prevalence of stunting. There is a significant influence between the type of breastfeeding (p=0.017) and the first food introduced (p=0.022) on the prevalence of wasting. The prevalence of malnutrition in Ayos locality was accentuated in children who received inadequate breastfeeding and feeding. Nutrition education for mothers could improve this situation.
儿童营养不良在全世界是一个严重的公共卫生问题,在喀麦隆尤其如此。本研究旨在评估Ayos地区6至59个月儿童的营养状况及其相关因素。这是一项横断面和描述性研究,于2019年8月至10月对309名儿童及其母亲进行了随机抽样。测量儿童的人体测量参数,使用问卷收集母亲和儿童饮食习惯的社会人口学数据,确定社会人口学因素、饮食习惯和营养不良之间的关系。结果:消瘦率为9.06%,重度消瘦率为3.56%;体重不足率为26.54%,重度消瘦率为10.03%;发育不良率为53.07%,重度消瘦率为34.96%。总体而言,86.1%的母亲对饮食多样性的概念理解不佳。首先引入的辅食是营养较差的当地粥,有40.52%的母亲使用,其次是家庭餐,有38.52%的母亲使用。婚姻状况(p=0.009)、教育水平(p=0.001)、职业(p=0.046)与慢性营养不良相关。母乳喂养类型(p=0.005)、添加辅食的年龄(p=0.004)、添加辅食的原因(p=0.002)与发育迟缓发生率有显著相关性。母乳喂养类型(p=0.017)和第一次食用的食物(p=0.022)对消瘦发生率有显著影响。在阿约斯地区,接受母乳喂养和喂养不足的儿童中,营养不良的普遍现象更为突出。对母亲进行营养教育可以改善这种状况。
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引用次数: 0
Microwave Treatment Prevents Cytomegalovirus Transmission to Preterm Infants through Human Milk 微波治疗防止巨细胞病毒通过母乳传播给早产儿
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-110000103
Mizuno K, Kohda C, D. H.
Background: Mother’s own milk (MOM) is the best nutrition for preterm infants; however, milk from cytomegalovirus (CMV)-seropositive mothers may cause the transmission of the virus to the infants. As extremely preterm infants are at a risk of developing serious conditions due to CMV infection, even MOM is sometimes pasteurized. Previously, we demonstrated that microwave heating of 50 mL formula milk containing CMV at 500 W for 40s prevented CMV infection in living cells. However, we do not know if this is the case with reactivated CMV in human milk (HM). Therefore, we investigated if microwave heating of HM would be effective in preventing CMV infection in living cells. Methods: Twenty-three CMV-IgG-positive and four CMV-IgG-negative mothers who donated HM to the human milk bank during 6 to 16 weeks postpartum were enrolled. The HM was treated with microwave at 500 W. HFL-III cells were seeded in culture dishes. Aliquots of HM samples subjected to microwave was inoculated onto susceptible cell monolayers. Infectious vial titer was measured by the 50% median tissue culture infectious Dose (TCID50) assay. Results: The TCID50 assay was decreased in five out of eight 100-mL samples after microwave at 200W for 60 s. The CMV infectivity assay was negative in three, decreased in eight, and no change in six 100-mL samples, and negative in four and decreased in eight 50-mL samples. Conclusions: Microwave heating of HM at low settings could decrease CMV transmission through HM, however, to obtain entire prevention is difficult when loss of bioactive properties is considered.
背景:母乳是早产儿最好的营养来源;然而,巨细胞病毒(CMV)血清阳性母亲的乳汁可能导致病毒传播给婴儿。由于极度早产的婴儿有因巨细胞病毒感染而发展成严重疾病的风险,即使是MOM有时也要进行巴氏消毒。在此之前,我们证明了用500 W微波加热含有巨细胞病毒的50 mL配方奶40秒可以防止活细胞感染巨细胞病毒。然而,我们不知道人乳中再激活的巨细胞病毒(HM)是否存在这种情况。因此,我们研究微波加热HM是否能有效预防CMV感染活细胞。方法:选取23例cmv - igg阳性母亲和4例cmv - igg阴性母亲,这些母亲在产后6 ~ 16周向人乳库捐献了HM。用500w的微波处理HM。将HFL-III细胞接种于培养皿中。等量的HM样品经微波处理后接种于敏感细胞单层上。采用50%组织培养感染中位剂量(TCID50)法测定感染滴度。结果:8份100 ml样品经200W微波作用60 s后,5份样品TCID50含量降低。CMV感染试验3例为阴性,8例下降,6例100 ml样品无变化,4例为阴性,8例50 ml样品下降。结论:微波低温加热可以降低CMV通过HM的传播,但考虑到生物活性的损失,很难完全预防CMV的传播。
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引用次数: 0
The Impact of COVID-19 Restrictions on Dietary and Lifestyle Habits of Hamad Medical Corporation staff (Public healthcare workers in Qatar) - A Crosssectional Survey COVID-19限制对哈马德医疗公司员工(卡塔尔公共卫生工作者)饮食和生活习惯的影响-横断面调查
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-110000100
Sibusiso Reuben Kutama, Noora Mohammed S Aljaffali, Reem Khalid A Al-Saadi, Anwar Mohd Faleh Qudaisat, E. Hany, Lindon Mark, M. Reynald, Miled Mohamed
Health care workers are on the frontline in the fight against the COVID-19 pandemic which has resulted in many containment measures associated with dietary and lifestyle changes and probable constrained public health delivery. Objectives: This study aims to determine whether COVID-19 induced restrictions have changed the dietary and lifestyle habits of Hamad Medical Corporation staff during the pandemic. Methods: A descriptive cross-sectional online survey was conducted, collecting pre COVID-19 pandemic details and current information of dietary and lifestyle habits of HMC staff without any interventions. The data was collected using validated modified self-administered online questionnaire, to collect data on demographics, and to explore the impact of COVID-19 induced restrictions on diet and physical activity patterns, and lifestyle habits. The study received ethical clearance from MRC Qatar. Results: The participants (n=248) were mostly female (57.3%) between the ages of 31-40 years (48.1%) all employed by Hamad Medical Corporation the principal healthcare provider in the State of Qatar. When BMI categories were grouped by gender 69.7% of females and 70.9% of males were found to be overweight. The data shows that vegetables consumption increased with 50% reporting an increase in fresh vegetables consumption but a decrease in fruits consumption and 31.5% reporting skipping 1 meal or more per day. Food items which were placed under the Sugar, Sweets and Others food group had a number of varied responses, with items like Jam 40.3%, soft/sugary drinks 22.2%, sugar 22.6%, ice cream 26.6% and pickles 25.0% being reported to have a higher percentage of being consumed more. Our results also show that 55.2% of participants in this survey do not engage in any specific physical activities, with 45.6% spending more than 4 hours per day doing sedentary activities. About 37.9% of participants decreased their sleeping time by 1-2 hours per day. Conclusion: This study suggests that the COVID-19 pandemic and the containment restrictions triggered weight gain, inadequate intake of a balanced diet and physical inactivity among healthcare workers in Qatar.
在抗击COVID-19大流行的斗争中,卫生保健工作者处于第一线,这导致了许多与饮食和生活方式改变相关的遏制措施,并可能限制公共卫生服务。目的:本研究旨在确定COVID-19引起的限制是否改变了哈马德医疗公司员工在大流行期间的饮食和生活习惯。方法:采用描述性横断面在线调查方法,在不采取任何干预措施的情况下,收集HMC工作人员在COVID-19大流行前的详细信息和当前的饮食和生活习惯信息。数据是通过经过验证的修改的自我管理在线问卷收集的,以收集人口统计数据,并探讨COVID-19引起的限制对饮食和身体活动模式以及生活习惯的影响。该研究获得了卡塔尔MRC的伦理许可。结果:参与者(n=248)大多为女性(57.3%),年龄在31-40岁之间(48.1%),均受雇于哈马德医疗公司,该公司是卡塔尔国的主要医疗保健提供者。当BMI指数按性别分组时,发现69.7%的女性和70.9%的男性超重。数据显示,蔬菜消费量增加,50%的人表示新鲜蔬菜消费量增加,但水果消费量减少,31.5%的人表示每天不吃一餐或更多。被归入糖、糖果和其他食品组的食品有许多不同的反应,据报道,果酱40.3%、软/含糖饮料22.2%、糖22.6%、冰淇淋26.6%和泡菜25.0%等食品的消费比例更高。我们的研究结果还显示,55.2%的调查参与者没有参加任何特定的体育活动,45.6%的人每天静坐的时间超过4小时。约37.9%的参与者每天减少1-2小时的睡眠时间。结论:本研究表明,2019冠状病毒病大流行和遏制措施导致卡塔尔医护人员体重增加、饮食不均衡和缺乏身体活动。
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引用次数: 0
Influence of Vacuum Packaging on Instrumental Surface Color Characteristics of Frozen Beef Steaks 真空包装对冷冻牛排仪器表面颜色特性的影响
Pub Date : 2022-01-01 DOI: 10.26502/jfsnr.2642-110000111
Madison P. Wagoner, Tristan M Reyes, Virgina E Zorn, Madison M Coursen, Katie E. Corbitt, Barney S Wilborn, T. Brandebourg, Aeriel D Belk, Tom Bonner, Jason T Sawyer
Consumers often consider beef color as a sole indicator of product freshness at the time of purchase. However, disruptions in meat manufacturing may cause manufacturers to create frozen retail meat products, but changes to surface color during frozen storage may be deleterious. Therefore, the objective for the current study was to determine the effect of vacuum packaging on instrumental surface color values of boneless ribeye steaks during frozen storage. Steaks were cut 2.54-cm-thick, assigned to one of three packaging films, allowed to bloom for 30 min and immediately frozen. Throughout the 25 days of frozen storage, instrumental surface color values were collected. Steaks packaged using MDF were lighter (p < 0.05) but became darker as storage time increased. However, redness (a*) values were greater (p < 0.05) for steaks packaged using MDF from day 10 to 25, as well as more yellow (b*) from day 7 to 25 (p < 0.05). Furthermore, steaks packaged in MDF were more (p < 0.05) vivid (C*) and possessed redder values for red-to-brown (RTB), oxymyoglobin (OMb), and hue angle from day 7 to 25 of the simulated storage period. These data indicate that choice of vacuum packaging film impacted instrumental surface color of frozen retail cuts with MDF packaging more effectively maintaining optimal color throughout the duration of this study.
在购买时,消费者通常将牛肉颜色视为产品新鲜度的唯一指标。然而,肉类生产的中断可能会导致制造商生产冷冻零售肉制品,但在冷冻储存期间表面颜色的变化可能是有害的。因此,本研究的目的是确定真空包装对冷冻储存期间无骨肋眼牛排仪器表面颜色值的影响。牛排被切成2.54厘米厚,被分配到三种包装薄膜中的一种,让它开花30分钟,然后立即冷冻。在25天的冷冻储存中,收集仪器表面颜色值。使用MDF包装的牛排重量较轻(p < 0.05),但随着储存时间的延长,颜色变深。然而,使用MDF包装的牛排在第10天至第25天红度(a*)值更高(p < 0.05),在第7天至第25天黄度(b*)值更高(p < 0.05)。此外,在模拟贮藏期的第7 ~ 25天,MDF包装的牛排颜色更鲜艳(p < 0.05),红棕色(RTB)、氧肌红蛋白(OMb)和色相角值更红。这些数据表明,真空包装膜的选择影响仪器表面颜色的冷冻零售切割与MDF包装更有效地保持最佳颜色在整个研究期间。
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引用次数: 0
Growth of Fusarium oxysporum (Schlencht) and Phoma exigua (Desm) isolated from Cowpea (Vigna unguiculata) in various concentrations of six different sugars 从豇豆(Vigna unguiculata)中分离的尖孢镰刀菌(Schlencht)和斑点病菌(Desm)在六种不同糖浓度下的生长
Pub Date : 2021-01-01 DOI: 10.26502/jfsnr.2642-11000083
Isalar Oluwatoyin F, Okom Cynthia, Omo-Udoyo Ejiroghene, Ataga Anthony E
A study was carried out on the growth of Fusarium oxysporum (Schlencht) and Phoma exigua (Desm) using six different sugars (sucrose, glucose, maltose, lactose, xylose and fructose) at various concentrations. The results showed that all the sugars supported growth of Fusarium oxysporum and Phoma exigua. The growth of Fusarium oxysporum and Phoma exigua in potato sucrose agar (PSA) attained optimum growth than glucose, maltose, lactose, xylose and fructose when used. Potato fructose agar supported the least growth of the fungi. Generally the concentration of sugars did not affect the growth of the organism.
采用不同浓度的蔗糖、葡萄糖、麦芽糖、乳糖、木糖和果糖对尖孢镰刀菌(Fusarium oxysporum, Schlencht)和镰刀菌(Phoma exigua, Desm)生长进行了研究。结果表明,所有糖均对尖孢镰刀菌和枯萎菌的生长有促进作用。马铃薯蔗糖琼脂(PSA)对尖孢镰刀菌(Fusarium oxysporum)和赤霉病菌(Phoma exigua)的生长效果优于葡萄糖、麦芽糖、乳糖、木糖和果糖。马铃薯果糖琼脂对真菌生长的支持作用最小。一般来说,糖的浓度不会影响有机体的生长。
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引用次数: 0
Biological Activity and Therapeutic Potential of Quercetin for Inflammatory Bowel Disease 槲皮素治疗炎症性肠病的生物活性和治疗潜力
Pub Date : 2021-01-01 DOI: 10.26502/jfsnr.2642-11000065
Alyssa Waslyk, M. Bakovic
Rates of inflammatory bowel disease (IBD) are increasing globally. IBD is an idiopathic chronic inflammatory disorder of the gastrointestinal tract characterized by acute disease flares and remission. IBD has a multifactorial pathogenesis whereby environmental and genetic factors contribute to disease onset. IBD is a serious clinical disorder that significantly impairs the patient’s quality of life, and is associated with increased morbidity, mortality, and cancer risk. IBD is characterized by the loss of tolerance to luminal antigens resulting in a persistent and excessive immune response. There is currently an unmet need for novel treatment options for patients with IBD. In recent years, flavonoids, a class of polyphenols widely distributed in fruits and vegetables gained significant interest as potential therapeutic agents for inflammatory disorders including IBD. Many flavonoids regulate cellular transcription factors critical in antioxidant and antiinflammatory pathways within the innate and adaptive immune response. Among these flavonoids, quercetin and its related glycosides have demonstrated remarkable effects capable of attenuating inflammation in experimental models of IBD. To date, many mechanisms underlying quercetin’s biological activity have been elucidated; wherein quercetin is reported to downregulate NFκB, MAPK, STAT and AP-1, and upregulate Nrf2. Thus, the aim of the review is to present the evidence surrounding quercetins biological activity, and its potential as a novel dietary intervention for IBD.
全球炎症性肠病(IBD)的发病率正在上升。IBD是一种特发性慢性胃肠道炎症性疾病,以急性发作和缓解为特征。IBD具有多因素发病机制,其中环境和遗传因素有助于疾病的发病。IBD是一种严重的临床疾病,严重损害患者的生活质量,并与发病率、死亡率和癌症风险增加有关。IBD的特点是失去对腔内抗原的耐受性,导致持续和过度的免疫反应。目前,对IBD患者的新型治疗方案的需求尚未得到满足。近年来,类黄酮作为一类广泛存在于水果和蔬菜中的多酚类物质,作为包括IBD在内的炎症性疾病的潜在治疗剂受到了极大的关注。许多类黄酮调节在先天和适应性免疫反应中抗氧化和抗炎途径中至关重要的细胞转录因子。在这些类黄酮中,槲皮素及其相关苷类在IBD实验模型中显示出显著的减轻炎症的作用。迄今为止,槲皮素生物活性的许多机制已被阐明;其中槲皮素下调NFκB、MAPK、STAT和AP-1,上调Nrf2。因此,本综述的目的是提供有关槲皮素生物活性的证据,以及它作为一种新的IBD饮食干预手段的潜力。
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引用次数: 2
期刊
Journal of Food Science and Nutrition Research
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