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An Audit and Analysis of Causes of Treatment Default in Head and Neck Cancer: A Single Tertiary Cancer Centre Experience 头颈癌治疗失败原因的审计与分析:一家三级癌症中心的经验
Pub Date : 2024-04-11 DOI: 10.11648/j.ijcocr.20240902.11
S. Baral, S. Silwal, Deep Lamichhane
Background: Treatment default is widespread among cancer patients and usually compromise patients’ clinical outcome. This not only compromises the management plan but also makes it harder to measure our treatment outcomes. Method: We reviewed Outpatient department (OPD) clinical record files of head and neck cancer patients who were registered at our hospital in a year. Patients were chosen on the basis of availability of record files at the time of sampling. All patients' OPD files were evaluated for treatment completion and causes of treatment default were recorded from the OPD record file. If information was not available in the OPD record file, patients or patients' relatives (if a contact number was available) were called for further information and cause of default. The Google spreadsheet was prepared to record demographics and causes of treatment default. Results: 72.19% were male among 205 patients analysed for the study. Most common site was oral cavity (30.24%), followed by oropharynx (21.9%), larynx (20%) and others. Intent was curative in 175 patients (85.36%) and palliative in 22patients (10.73%). 112 curative intent patients (64%) and 11 palliative intent (50%) completed planned treatment, 27 curative intent patients (15.42%) and 7 palliative patients (31.81%) defaulted during treatment and 36 curative patients (20.57%) and 4 palliative patients (18.18%) defaulted before starting Primary treatment (Surgery or Radiotherapy). Treatment related toxicities in 20 patients (26.31%) waiting time for radiotherapy in 14 patients (18.42%) were major causes of default in this study. In curative intent cases, 44 patients (39.28%) had complete response, 41 patients (36.3%) had partial response, 10 patients (8.92%) had progressive disease and 6 patients (5.35%) had metastatic disease, 3-month post treatment. Conclusion: Among various reasons for noncompliance, few can be addressed immediately like arranging multidisciplinary team discussions at an institutional level to prioritize management. Further large-scale studies are needed to estimate the exact dimensions of the issues in our setup.
背景:癌症患者中普遍存在治疗违约现象,这通常会影响患者的临床疗效。这不仅会影响治疗计划,还会增加衡量治疗效果的难度。研究方法我们查阅了本医院门诊部(OPD)一年内登记的头颈部癌症患者的临床记录档案。选择患者的依据是抽样时是否有记录档案。对所有患者的 OPD 档案进行治疗完成情况评估,并从 OPD 记录档案中记录治疗失败的原因。如果 OPD 记录档案中没有相关信息,则会致电患者或患者亲属(如果有联系电话)询问进一步信息和违约原因。谷歌电子表格用于记录人口统计数据和不接受治疗的原因。结果在研究分析的 205 名患者中,72.19% 为男性。最常见的部位是口腔(30.24%),其次是口咽(21.9%)、喉(20%)和其他部位。175名患者(85.36%)的治疗目的是治愈,22名患者(10.73%)的治疗目的是缓解。112 名治愈患者(64%)和 11 名姑息患者(50%)完成了计划治疗,27 名治愈患者(15.42%)和 7 名姑息患者(31.81%)在治疗过程中违约,36 名治愈患者(20.57%)和 4 名姑息患者(18.18%)在开始初级治疗(手术或放疗)前违约。在本研究中,20 名患者(26.31%)的治疗相关毒性反应和 14 名患者(18.42%)的放疗等待时间是导致患者违约的主要原因。在治疗后 3 个月的治愈病例中,44 名患者(39.28%)有完全反应,41 名患者(36.3%)有部分反应,10 名患者(8.92%)病情进展,6 名患者(5.35%)有转移性疾病。结论在导致不依从治疗的各种原因中,只有少数几个原因可以立即解决,如在机构层面安排多学科团队讨论,以确定管理的优先次序。我们需要进一步开展大规模研究,以估算在我们的情况下这些问题的确切范围。
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引用次数: 0
Comparative Study of Whole Brain Radiotherapy vs Whole Brain Radiotherapy with Concurrent Temozolomide in Brain Metastases 脑转移瘤的全脑放疗与全脑放疗并用替莫唑胺的比较研究
Pub Date : 2024-01-08 DOI: 10.11648/j.ijcocr.20240901.11
Md. Ruhul Amin Bhuiyan, Farhana Hussain Sadia, Ahammad Al Mamun Sweet, Md Ershadul Haque, Khandaker Md. Rezwan Bayzid, Azm Sumsuzoha, A. Chowdhury, Md. Abdul Mannan
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引用次数: 0
Epidemiological, Diagnostic, Therapeutic and Evolutionary Profile of Inflammatory Breast Cancer (IBC) in the Oncology-Hematology Service, Burkina Faso 布基纳法索肿瘤血液科炎症性乳腺癌 (IBC) 的流行病学、诊断、治疗和演变概况
Pub Date : 2023-12-06 DOI: 10.11648/j.ijcocr.20230804.12
Bambara Hierrhum Aboubacar, Zoure Abdou Azaque, Zerbo Nina Assanatou Jumelle, Yameogo Prisca Emmanuelle Aida, Adico Marc Donald Wilfried, Odero-Marah Valérie
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引用次数: 0
Prognostic Factors for Prostate Cancer at the Brazzaville University Hospital Center 布拉柴维尔大学医院中心前列腺癌的预后因素
Pub Date : 2023-12-06 DOI: 10.11648/j.ijcocr.20230804.13
Bambara Hierrhum Aboubacar, Zerbo Nina Assanatou Jumelle, Odero-Marah Valérie, Nkoua Epala Brice Aymard, Nsonde Malanda Judith, Nkoua-Mbon Jean-Bernard
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引用次数: 0
Precancerous Lesions of the Cervix: Screening and Management at the Matam Maternity Hospital and the Donka Gynaecological Cancer Prevention Centre (Guinea) 宫颈癌前病变:马塔姆妇产医院和东卡妇科癌症预防中心的筛查和管理(几内亚)
Pub Date : 2023-11-21 DOI: 10.11648/j.ijcocr.20230804.11
Conté Ibrahima, Kouyaté Sekouba, Leno Daniel William Atanase, Diallo Thierno Ibrahima, Sow Alhassane Mohamed, Diallo Yaya, S. Telly, Hyjazi Yolande, K. Namory
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引用次数: 0
Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa 营养教育对营养状况、耐受性和化疗反应的影响:中非喀麦隆杜阿拉总医院的经验
Pub Date : 2023-09-06 DOI: 10.11648/j.ijcocr.20230803.12
Dina Bell Esther Hortense Murielle, Esson Mapoko Berthe, Sango Anne, A. Etienne, Maïson Mayeh, Mekah Mapenya, Ndangue Ntone Nancy, Anaba Dominique, Ntama Ambroise, Aminatou Ada, Mbemmo Murielle Laure, Ngo Bikond Grace, Yondo Edimo Suzanne, Mouelle Mbassi W, Mouelle Michel, Tchakounté Boris, Ananga Noa, Mananga Jean Charles, H.D.G. Mbiatat, Njock Louis Richard
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引用次数: 0
Social Representation of Cancer among Nurses in Burkina Faso and Influence on Early Diagnosis of Cancer 布基纳法索护士对癌症的社会代表性及其对癌症早期诊断的影响
Pub Date : 2023-08-17 DOI: 10.11648/j.ijcocr.20230803.11
Augustin Tozoula Bambara, Michel Ilboudo, Dagnagnewende Dieudonne Kabore, Pingwende Fidele Kabore, Alice Cynthia Sama
: Objective : We conducted this study with the aim of determining the association between the social representation of cancer of nurses in Ouagadougou and the decision they make when faced with a sign suggestive of cancer. Methods : We conducted a survey over a period from December 27, 2022 to March 26, 2023 in the city of Ouagadougou. A total of 341 nurses working in the Health and Social Promotion Centers participated in the survey by completing a questionnaire. They were asked to produce a series of five words that came to mind spontaneously from the word “cancer” inducer then to rank these words in descending order of importance according to their judgment. The subjects surveyed were finally asked about their practices in front of signs suggestive of cancer. These practices have been categorized into “I refer” and “I do not refer” to a higher level of care. We compared these two groups through a prototypical analysis using the Iramuteq software. Results : In group 1, the central core was composed of 8 words which are: Pain, Incurable, Suffering, Breast, Nodule, Chemotherapy, Expensive, Tumor. The second periphery was composed of: Death, Fear, Metastasis, Chronic, Expenditure, Compassion, Serious. In group 2, the core was composed of 15 words which are Death, Pain, Tumor, Suffering, Expensive, Metastasis, Nodule. The first periphery was composed of the following words: Fear, Incurable, Chemotherapy, Chronic. The maximum tree of representation indicates that the words cited in both groups are organized around the words “death”, “pain”, “incurable” and “fear”. Conclusion : This difference in perception of the disease has a probable influence on their readiness to refer patients to health centers better equipped for patient management. It seems necessary to reflect on ways to train nurses, to inform them about cancer and on the benefits of adequate and early management.
目的:我们进行这项研究的目的是确定瓦加杜古护士癌症的社会代表性与他们面对癌症迹象时做出的决定之间的关系。方法:我们于2022年12月27日至2023年3月26日在瓦加杜古市进行了一项调查。共有341名在健康与社会促进中心工作的护士通过填写问卷参与了调查。他们被要求从“癌症”这个词中自发地想到一系列五个词,然后根据他们的判断将这些词的重要性按降序排列。最后,调查对象被问及他们在癌症迹象面前的行为。这些做法被分为“我参考”和“我不参考”更高级别的护理。我们使用Iramuteq软件对这两组进行了原型分析。结果:1组中心核心由疼痛、无法治愈、痛苦、乳房、结节、化疗、昂贵、肿瘤8个词组成。第二个外围包括:死亡、恐惧、转移、慢性、消耗、同情、严重。第二组的核心词由死亡、疼痛、肿瘤、痛苦、昂贵、转移、结节等15个词组成。第一个外围由以下几个词组成:恐惧,无法治愈,化疗,慢性。最大代表树表明,两组引用的单词都是围绕“死亡”、“痛苦”、“无法治愈”和“恐惧”等词组织的。结论:这种对疾病感知的差异可能会影响他们是否准备将患者转介到配备更好的患者管理的健康中心。似乎有必要反思培训护士的方式,让她们了解癌症,以及充分和早期管理的好处。
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引用次数: 0
The Role of Peptide Immunotherapy in the Treatment of Cervical Dysplasia: Clinical Cases 肽免疫疗法在治疗宫颈发育不良中的作用:临床病例
Pub Date : 2023-05-25 DOI: 10.11648/j.ijcocr.20230802.13
О.V. Bulavenko, Тetiana Lunko, Оleksii Таtskyy, Тetiana Fomina, Мaria Pikul, Оleksandr Zdanevych, Mykhailo Каzarnovskyy, Victor Zadorozhnyy, Svitlana Тurbanist, Svitlana Pysmenna, Olena Yamkova-Bodnaruk, Liudmyla Lytvynchuk
: Introduction . Since one of the main factors determining the pathogenic effect of HPV infection is local immunodeficiency, a number of authors suggest using various cytokines and immunomodulators. Recently, peptide-based agents have been increasingly used in routine clinical practice. Objective . To study the effect of peptide immunocorrection on molecular and cellular factors affecting the course of grade II cervical dysplasia (CIN2) as a precancerous process and to evaluate the effectiveness of the proposed regimen. Materials and methods . The study included 2 groups of patients aged 28 to 44 years who were colposcopically and cytologically diagnosed with grade 2 cervical dysplasia. Clinical monitoring, determination of HPV by PCR, immunohistochemical studies of biomarkers of inflammation and proliferation, as well as counting of T-lymphocytes in cervical mucus preparations were performed before treatment, after treatment, after 6 weeks and after 3 months. Results . During the study of the expression level of pro-oncogenic interleukin IL-8 and anti-oncogenic IL-12, it was established that in both observation groups after the immunotherapy, a tendency to decrease the pro-oncogenic potential of cervical mucus was noted. Analysis of the level of expression of the cell proliferation marker Ki-67 in the clinical monitoring groups showed that the proposed therapy schemes reduced the proliferative potential of the cervical epithelium. The number of active cytotoxic lymphocytes in the cervical mucus in both observation groups predictably increased after the use of local immunotherapy. The study showed that immunotherapy of cervical dysplasia with the use of peptides demonstrated significantly better clinical results compared to the reference group. Conclusion . Taking into account the obtained research results and the given clinical cases, peptide immunocorrection can be reasonably recommended as an immunological component in the treatment of cervical dysplasia (ASCUS and LSIL).
:介绍。由于决定HPV感染致病性的主要因素之一是局部免疫缺陷,许多作者建议使用各种细胞因子和免疫调节剂。近年来,肽类药物已越来越多地用于常规临床实践。目标。研究肽免疫校正对影响II级宫颈发育不良(CIN2)作为癌前病变过程的分子和细胞因素的影响,并评估所建议方案的有效性。材料和方法。该研究包括两组年龄在28至44岁的患者,经阴道镜检查和细胞学诊断为2级宫颈发育不良。治疗前、治疗后、治疗后6周和治疗后3个月进行临床监测、HPV PCR检测、炎症和增殖生物标志物免疫组化研究、宫颈黏液制剂t淋巴细胞计数。结果。在对促癌性白细胞介素IL-8和抗癌性IL-12表达水平的研究中,我们发现在免疫治疗后,两个观察组宫颈粘液的促癌潜能都有降低的趋势。对临床监测组细胞增殖标志物Ki-67的表达水平分析表明,所提出的治疗方案降低了宫颈上皮的增殖潜能。两组患者在局部免疫治疗后,宫颈黏液中活性细胞毒性淋巴细胞的数量均可预测地增加。研究表明,与对照组相比,使用多肽免疫治疗宫颈发育不良的临床效果明显更好。结论。结合已有的研究结果和临床病例,可以合理推荐多肽免疫矫正作为治疗宫颈发育不良(ASCUS和LSIL)的免疫成分。
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引用次数: 0
Epidemiological and Therapeutic Aspects of the Single Visit Approach in the Management of Precancerous Lesions of the Cervix in Guinea Conakry in 2022 2022年几内亚科纳克里宫颈癌前病变单次就诊方法的流行病学和治疗方面
Pub Date : 2023-05-22 DOI: 10.11648/j.ijcocr.20230802.12
Soumah Aboubacar Fode Momo, Conté Ibrahima, Leno Daniel Williams Atanasse, S. Ibrahima
: Objective: to evaluate the epidemiological and therapeutic aspects of the single visit approach in the management of precancerous lesions of the cervix in the CECAP sites of Conakry in 2022. Methodology : This was a multicenter cross-sectional descriptive study, using retrospective data at the six CECAP sites from July 1 to Conakry. Three data collection tools: the individual form, a screening register, and a monthly summary sheet or reporting template, were used to track key single-visit service variables: the number of women screened using VIA, proportion of women screened positive for VIA and proportion of women screened VIA positive who received cryotherapy on the same day, KoBo Collect served the collections and the analysis was carried out by the software EPI info version 7.2 6. Results : during our three-month study, in the six pilot sites of Conakry, 786 women were screened, of whom 3.18% (25/786), had IVA+, 62.5% benefited from cryotherapy the same day, it was postponed in 37.5% of cases, the program did not train providers in the management of large lesions, which is one of the limitations of our study. Conclusion : Visual inspection with acetic acid is a simple test, requiring minimal infrastructure and expense, little provider training. The integration of VIA with cryotherapy at the primary care level in the communal medical centers of the city of Conakry, could constitute a feasible program for the prevention of cervical cancer in Guinea.
目的:评价2022年科纳克里CECAP地区宫颈癌前病变单次就诊的流行病学和治疗方面的情况。方法:这是一项多中心横断面描述性研究,使用7月1日至科纳克里六个CECAP站点的回顾性数据。三种数据收集工具:个人表格、筛查登记表和月度汇总表或报告模板,用于跟踪关键的单次就诊服务变量:使用VIA筛查的妇女人数、VIA筛查阳性妇女的比例和同一天接受冷冻治疗的VIA筛查阳性妇女的比例。KoBo Collect提供收集服务,并通过EPI信息7.2版软件进行分析。结果:在我们为期三个月的研究中,在科纳克里的6个试验点,筛查了786名妇女,其中3.18%(25/786)的妇女接受了IVA+, 62.5%的妇女当天受益于冷冻治疗,37.5%的病例推迟了冷冻治疗,该计划没有培训提供者管理大病变,这是我们研究的局限性之一。结论:醋酸目视检查是一种简单的检查方法,所需的基础设施和费用很少,对提供者的培训也很少。在科纳克里市公共医疗中心的初级保健一级,将VIA与冷冻疗法结合起来,可构成几内亚预防宫颈癌的一项可行方案。
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引用次数: 0
Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer 致死性局部晚期非小细胞肺癌减分割姑息放疗2段17 Gy与10段30 Gy的比较研究
Pub Date : 2023-05-10 DOI: 10.11648/j.ijcocr.20230802.11
Kamrun Nahar Tania, Jannatun Nisa, Moarraf Hossen, Muhammad Masudul Hassan Arup, Muhammad Abdullah-Al-Noman, Mohammad Shaiful Hassan Shameem, Sonya Begum, M. Arifur Rahman
Comparative Study of Hypofractionated
低分割的比较研究
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引用次数: 0
期刊
International Journal of Clinical Oncology and Cancer Research
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