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Tumors Registry in Low Income Countries’ Hospital: A Retrospective Study of 350 Cases in the Democratic Republic of Congo from 2007 to 2017 低收入国家医院肿瘤登记:2007年至2017年刚果民主共和国350例病例回顾性研究
Pub Date : 2019-06-11 DOI: 10.11648/J.IJCOCR.20190402.13
M. Didier, Kyabu Véronique, M. Phillipe, M. Abdon, I. Julien
Tumors had been misdiagnosed and under- documented for longtime in Africa. The Democratic Republic of Congo (DRC) has not any cancer registry available up today. The National Cancer Registry is an important tool to deal with cancer management, especially for the National Cancer Plan and cancer prevention. The African Cancer Registry Network (AFCRN) is trying to help many Countries to hold their national Registries in hope to provide tumors’ data. Despite National Cancer Registry, hospital Registries can be used for preliminary researches. This is a retrospective study performed to determine epidemiological and clinical data of tumors in Lubumbashi City, the second city in DRC, especially in the mines’ hospital during the period from 2007 to 2017. The authors collected data from 350 patients aged from 2 and 94 years. The average age was 46.3 ± 17.9 years. There were 299 Females and 51 males; means 85.4 vs 14.6%. Tumors of the female reproductive system accounted for 72.9%. Diagnosis was made by echography in 59.7% of cases. Palliative care was the main treatment in 51% of cases. This study has enlightened the fact that tumors are a serious problem of health in the Democratic Republic of Congo and there are many challenges to improve cancer survival in this country.
长期以来,肿瘤在非洲一直被误诊和记录不足。刚果民主共和国(DRC)目前没有任何癌症登记。国家癌症登记是处理癌症管理的重要工具,特别是对于国家癌症计划和癌症预防。非洲癌症登记网络(AFCRN)正试图帮助许多国家建立他们的国家登记处,以期提供肿瘤数据。尽管有国家癌症登记处,但医院登记处可用于初步研究。这是一项回顾性研究,旨在确定2007年至2017年期间刚果民主共和国第二大城市卢本巴希市,特别是矿山医院的肿瘤流行病学和临床数据。作者收集了350名患者的数据,年龄从2岁到94岁不等。平均年龄46.3±17.9岁。其中女性299人,男性51人;平均值85.4 vs 14.6%。女性生殖系统肿瘤占72.9%。超声诊断率为59.7%。51%的病例以姑息治疗为主。这项研究揭示了这样一个事实:肿瘤在刚果民主共和国是一个严重的健康问题,在这个国家,提高癌症存活率存在许多挑战。
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引用次数: 0
Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature Ommaya水库相关并发症:单一中心经验和当前文献综述
Pub Date : 2019-06-11 DOI: 10.11648/J.IJCOCR.20190402.12
Azka Ali, R. Bosse, B. Doonan, P. Narayan, Grant Jester, J. DeLaune, Jacob Barish, Samantha Welniak, H. Norton, C. Heldermon
First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.
OmRs于1963年首次引入,是脑室内留置导管,用于脑积水减压、抗生素和化疗输送。当腰椎穿刺不实际或需要长期用药时,它们是重要的替代方案。尽管使用了50多年,这些装置的放置仍然可能导致显著的发病率和死亡率。我们在佛罗里达大学癌症中心进行了一项单中心回顾性研究,评估了OmR接受化疗的患者的OmR相关并发症。我们还进行了一项系统的回顾,在化疗递送设置OmR相关和LP并发症。13例患者符合纳入本回顾性研究的标准。评估并发症的时间点为:放置、6个月、6-12个月、> 12个月、取出和出院后。我们的机构数据显示,每个时间点的复杂比率都小于7%。在系统评价中,38项研究纳入了OmR数据,8项研究纳入了LP数据。感染性并发症在OmR研究中更为普遍,差异有统计学意义(p=0.0017),而非感染性并发症在LP研究中更为普遍,差异有统计学意义(p=0.0004)。本研究比较了通过Ommaya贮液器和腰椎穿刺接受鞘内化疗的患者的感染性和非感染性并发症发生率。OmR在长期给药中非常有用,相对较高的并发症发生率(特别是传染性)可被认为是高发病率患者群体可接受的风险。
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引用次数: 2
Human Papillomavirus and Cervical Intra-Epithelial Neoplasia: Epidemiological and Cytological Study in Lubumbashi Women 人乳头瘤病毒和宫颈上皮内瘤变:卢本巴希妇女的流行病学和细胞学研究
Pub Date : 2019-05-30 DOI: 10.11648/J.IJCOCR.20190401.11
M. Didier, Kyabu Véronique, M. Philippe, Mukalay Abdon, C. Joseph, Kalenga Prosper, I. Julien
The objective of this study is to show that the presence of koilocytosis on the cervical smear is the only possibility to detect Papillomavirus infection in cervical intra-epithelial neoplasia in women living in Lubumbashi. This is a cross-sectional analytical study on the data collected from the register of women who participated in the cervix lesion screening campaign organized in Lubumbashi in March 2012 by the Congolese League Against Cancer. A total of 545 women with cervical lesions have been selected. The following results were observed: the frequency of HPV infection is 35% in Lubumbashi women. The risk of developing intraepithelial neoplasia is 38.3 times higher in women infected with HPV compared to uninfected ones (OR = 38.3, 95% CI = 16.3-90.3). HPV is predominantly present in intraepithelial neoplasia (92.7%) and this regardless of their grade: 91.9% for low-grade neoplasia and 95% for high-grade neoplasia. HPV is found in both older women and older women, respectively in 45% of women aged less than 36 years and in 55% of women aged over 36 years old. This study shows that it is necessary to put in place adequate means for the detection of HPV in order to contribute to the fight against cervical cancer in Lubumbashi.
本研究的目的是表明,宫颈涂片上有白细胞增多症是卢本巴希妇女宫颈上皮内瘤变中检测乳头瘤病毒感染的唯一可能性。这是对2012年3月在卢本巴希参加刚果抗癌联盟组织的子宫颈病变筛查运动的妇女登记册收集的数据进行的横断面分析研究。共有545名患有宫颈病变的妇女被选中。观察到以下结果:卢本巴希妇女的HPV感染频率为35%。与未感染HPV的女性相比,感染HPV的女性发生上皮内瘤变的风险高38.3倍(OR = 38.3, 95% CI = 16.3-90.3)。HPV主要存在于上皮内瘤变中(92.7%),与级别无关:低级别瘤变为91.9%,高级别瘤变为95%。HPV在老年妇女和老年妇女中均有发现,分别在45%的36岁以下妇女和55%的36岁以上妇女中发现。这项研究表明,有必要采取适当的手段检测人乳头瘤病毒,以便为卢本巴希防治宫颈癌作出贡献。
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引用次数: 2
The Effects of Plasma-Activated Saline and Medium on Colorectal Cancer in Rat Models and the Human Colon Adenocarcinoma Cell Line COLO 205 血浆活化盐水和培养基对大鼠结直肠癌模型和人结肠腺癌细胞COLO 205的影响
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20220701.12
Genu Takahashi, Nanako Okuno, Kyotaro Yoshino, T. Hirata, Chihiro Kobayashi, Akira Mori, M. Watada
: Colorectal cancer affects a large number of people. There is an urgent need to develop novel treatments for this disease. In recent years, research on medical applications of atmospheric low temperature plasma (ALTP) has been actively conducted
结直肠癌影响很多人。迫切需要开发治疗这种疾病的新方法。近年来,大气低温等离子体(ALTP)的医学应用研究得到了积极开展
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引用次数: 1
Effect of Predictive Nursing Intervention on the Gastrointestinal Side Effects of I-131 Re-treatment in Patients with Differentiated Thyroid Cancer (DTC) 预测性护理干预对分化型甲状腺癌(DTC)患者I-131再治疗胃肠道不良反应的影响
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20220702.15
Miaoli Zhou, Yanlan Liu, Qingran Lin, Jinmei Xiong, Bin Guo, Hao Xu
: Objective: The aim of this study was to explore the effect of predictive nursing intervention on the gastrointestinal side effects of I-131 re-treatment in patients with differentiated thyroid cancer (DTC). Methods: From January 2017 to August 2018, we invited patient with DTC who received I-131 re-treatment to enroll in this study. The participants were randomly assigned to control or predictive nursing intervention groups using a random number table. The primary outcomes were the incidence of gastrointestinal side effects and degree of patient satisfaction with respect to nursing. Patients in the intervention group received predictive nursing intervention, and patients in the control group received common nursing intervention. Result: A total of 69 patients were enrolled in the study. In patient characteristic, the gender, age and disease status were no significantly different for the participants in two groups. In addition, intervention group participants had less gastrointestinal side effect events, including nausea, vomiting and anorexia (10 vs 3, 8 vs 1, 12 vs 2). In nursing satisfaction assessment, intervention group participants provided better outcome in nursing satisfaction assessment compared with control group, that they provided most very satisfied assessment to predictive nursing intervention. Conclusion: Predictive nursing helped decrease the incidence of gastrointestinal side effects and improved patient satisfaction with nursing. Predictive nursing may be effective in DTC patients receiving I-131 re-treatment.
目的:探讨预测性护理干预对分化型甲状腺癌(DTC)患者I-131再治疗胃肠道不良反应的影响。方法:2017年1月至2018年8月,我们邀请接受I-131再治疗的DTC患者加入本研究。采用随机数字表法将参与者随机分为对照组和预见性护理干预组。主要结果是胃肠道副作用的发生率和患者对护理的满意度。干预组患者接受预测性护理干预,对照组患者接受常规护理干预。结果:共有69例患者入组研究。在患者特征上,两组患者的性别、年龄、疾病状况无显著差异。此外,干预组患者恶心、呕吐、厌食等胃肠道不良反应发生率较低(10 vs 3, 8 vs 1, 12 vs 2)。在护理满意度评估中,干预组患者的护理满意度评估结果优于对照组,对预测性护理干预的满意度评价最高。结论:预测性护理有助于减少胃肠道不良反应的发生,提高患者对护理的满意度。预测性护理对接受I-131再治疗的DTC患者可能有效。
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引用次数: 0
COVID-19 Vaccine Safety in Cancer Patients: A Single Center Experience 2019冠状病毒病疫苗在癌症患者中的安全性:单一中心体验
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20220702.13
A. Bensalem, Abdellaziz Ammari, Chouaib Hellal, S. Bensalem, K. Bouzid, Nour El Houda Kellab, Houda Meguellati, Amina Boudraa, Asma Seghiri, O. Messalbi, Meryem Barani, Nour El Houda Sloula, Samia Kouartel, Asma Bououdina, Amira Sadou, Tarek Bendjeddou, Hiba Rais, Nour El Islam Mecheri, Nadjet Lachter, Meryem Boudjerda
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引用次数: 0
A Case Report on Idiopathic-Multi-centric Castleman’s Disease Associated POEMS- Syndrome 特发性多中心Castleman病相关POEMS综合征1例报告
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20220701.13
Amritha Radhakrishnan Nair, Changaramkumarath Gichin, Deepa Pramod Raj Santhi, Moothiringode Chithrabhanu Savithri
: Castleman’s Disease is a rare lymphoproliferative disorder of idiopathic etio-pathogenesis and was first described by Dr Benjamin Castleman in 1954. It is a rather rare disease entity in clinical practice. However, the incidence cannot be ignored. It may affect a single lymph node (Unicentric CD) or multiple lymph nodes throughout the body (Multicentric CD). Management depends upon the type and severity of the disease and early recognition of the condition. Our case report is that of a 60-year-old female patient with underlying comorbidities including type 2 diabetes mellitus, hypothyroidism who presented with complaints of generalized weakness, weight loss, hair loss, non-resolving muco-purulent rhinorrhea, bilateral pedal edema and multiple, non-tender, firm and mobile left sided Level I and II ‘AJCC’ cervical lymphadenopathy of >2cm which was later biopsied and diagnosed to be Castleman’s disease associated POEMS syndrome. The aim of this report is to consider CD as a differential diagnosis in patients presenting with similar clinical picture and early identification and treatment may provide a better prognosis. We would also like to highlight 3 take home points: 1) The significance of histology in differentiating it from other lymph proliferative conditions. 2) LN excision of the bothersome LN can be diagnostic and may be considered therapeutic to some extend even in MCD. 3) Steroid therapy has beneficial effects to control progression of the disease.
Castleman病是一种罕见的特发性淋巴细胞增生性疾病,由Benjamin Castleman博士于1954年首次发现。在临床实践中是一种相当罕见的疾病。然而,发病率不容忽视。它可能影响单个淋巴结(单中心性CD)或整个身体的多个淋巴结(多中心性CD)。管理取决于疾病的类型和严重程度以及病情的早期识别。我们的病例报告是一名60岁的女性患者,其潜在的合并症包括2型糖尿病,甲状腺功能减退,其主诉为全身无力,体重减轻,脱发,无法解决的粘液化脓性鼻漏,双侧足部水肿和左侧多发,非压痛,坚硬和移动的I级和II级AJCC颈椎淋巴结病变,>2cm,后来活检并诊断为Castleman病相关POEMS综合征。本报告的目的是考虑将乳糜泻作为具有相似临床表现的患者的鉴别诊断,早期识别和治疗可能提供更好的预后。我们还想强调3个要点:1)组织学在将其与其他淋巴增生性疾病区分开来方面的意义。2)即使在MCD中,切除麻烦的LN也可以诊断并在一定程度上被认为是治疗性的。类固醇治疗对控制病情进展有有益作用。
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引用次数: 0
Initiating Conversations on Integrative Oncology Amongst Cancer Professionals, Integrative Medicine Practitioners and Cancer Patients – The CANCERTALK Initiative 在癌症专家、中西医结合医师和癌症患者之间发起关于中西医结合肿瘤学的对话- CANCERTALK倡议
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20210604.13
P. Kechagioglou, R. Daly
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引用次数: 0
Challenges and Prospects for Providing Radiotherapy Services in Nepal 尼泊尔提供放射治疗服务的挑战和前景
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20220702.11
Saloni Chawla, S. Thakur
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引用次数: 0
Anti-EGFR–Based Treatment of Patients with Metastatic Colorectal Cancer: Data from the National Oncology Institute of Panama 基于抗egfr的治疗转移性结直肠癌患者:来自巴拿马国家肿瘤研究所的数据
Pub Date : 1900-01-01 DOI: 10.11648/j.ijcocr.20220702.14
Kayra Sánchez-Muñoz, José Pinto-Llerena
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引用次数: 0
期刊
International Journal of Clinical Oncology and Cancer Research
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