Pub Date : 2023-04-11DOI: 10.11648/j.ijcocr.20230801.13
Liu Chao, L. Chiuman
{"title":"Analysis of the Characteristics of Colorectal Cancer or Malignant Colorectal Tumors Transferred to Other Organs: A Population-Based Study","authors":"Liu Chao, L. Chiuman","doi":"10.11648/j.ijcocr.20230801.13","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230801.13","url":null,"abstract":"","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122126783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.11648/j.ijcocr.20230801.11
Nimkur Lohpon Tonga, Obebe Francis Ameh, Okoye Chukwuma, J. Emmanuel
: Introduction : Lymphomas are heterogeneous group of lymphoid tissues traditionally categorized as either Hodgkin’s Lymphoma (HL) or Non-Hodgkin’s Lymphoma (NHL). The head and neck region is rich in lymphoid tissues, thus a fertile anatomic site for the development of lymphoid proliferative diseases like lymphomas. In the head and neck, malignant lymphomas account for 5% of all malignant neoplasm; Non-Hodgkin’s Lymphoma (NHL) is the most common accounting for 75%. The clinical behaviour and manifestations of Lymphomas in the head and neck lack specific characteristics that would enable attribution to a specific lymphoma entity without biopsy and histological evidence. Materials and Methods : It is a 5 year retrospective study of confirmed histopathological analysis of head and neck lymphomas from 1 st January 2017 to31 st December 2021. Case notes of all histopathologically confirmed head and neck lymphomas were retrieved from the medical records department and also theatre records as supportive data were analysed for age, sex, histological diagnosis, tumour site, duration of symptoms before presentation and treatment modality; and then discussed. Results :- The total number of patients seen during the period under review was 1678, 16 patients had histopathologically confirmed lymphomas out of 388 patients with head and neck tumours, thus prevalence of 0.1% and 4.1% of all head and neck tumours. Male to Female ratio of 5:1, age range of 4 to 62 years, mean age of 29 years. Most common tumour site is the cervical region-315; the most frequently seen histological type is the Non Hodgkin’s lymphoma (NHL) and the most common duration of symptom before presentation is over 1 year-50%. All patients had chemotherapy as a treatment modality. Conclusion : This study reveals the management challenges of the head and neck lymphomas are due to late presentation, financial constraints and ignorance. Health awareness and adequate Health Insurance Policy are needed to cope or mitigate these problems.
{"title":"Head and Neck Lymphomas in Jos University Teaching Hospital Nigeria: A Five Year Review","authors":"Nimkur Lohpon Tonga, Obebe Francis Ameh, Okoye Chukwuma, J. Emmanuel","doi":"10.11648/j.ijcocr.20230801.11","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230801.11","url":null,"abstract":": Introduction : Lymphomas are heterogeneous group of lymphoid tissues traditionally categorized as either Hodgkin’s Lymphoma (HL) or Non-Hodgkin’s Lymphoma (NHL). The head and neck region is rich in lymphoid tissues, thus a fertile anatomic site for the development of lymphoid proliferative diseases like lymphomas. In the head and neck, malignant lymphomas account for 5% of all malignant neoplasm; Non-Hodgkin’s Lymphoma (NHL) is the most common accounting for 75%. The clinical behaviour and manifestations of Lymphomas in the head and neck lack specific characteristics that would enable attribution to a specific lymphoma entity without biopsy and histological evidence. Materials and Methods : It is a 5 year retrospective study of confirmed histopathological analysis of head and neck lymphomas from 1 st January 2017 to31 st December 2021. Case notes of all histopathologically confirmed head and neck lymphomas were retrieved from the medical records department and also theatre records as supportive data were analysed for age, sex, histological diagnosis, tumour site, duration of symptoms before presentation and treatment modality; and then discussed. Results :- The total number of patients seen during the period under review was 1678, 16 patients had histopathologically confirmed lymphomas out of 388 patients with head and neck tumours, thus prevalence of 0.1% and 4.1% of all head and neck tumours. Male to Female ratio of 5:1, age range of 4 to 62 years, mean age of 29 years. Most common tumour site is the cervical region-315; the most frequently seen histological type is the Non Hodgkin’s lymphoma (NHL) and the most common duration of symptom before presentation is over 1 year-50%. All patients had chemotherapy as a treatment modality. Conclusion : This study reveals the management challenges of the head and neck lymphomas are due to late presentation, financial constraints and ignorance. Health awareness and adequate Health Insurance Policy are needed to cope or mitigate these problems.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123307579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.11648/j.ijcocr.20230801.12
Gonçalo Januário
: Intracranial lipoma is a uncommon congenital malformation, represent less than 0.1% of all intracranial tumors. Result from abnormal persistence and mal-differentiation of meninx primitiva, during embryogenesis. The cases in which the tumor presents an extracranial component are caused by a secondary dehiscence of the skull with evagination of a small tuft of primitive meninges. These lesions are frequently located in the inter-hemispheric fissure in the pericallosal region in 50% of cases, other locations as ambient or quadrigeminal cisterns present an incidence about 20-25%. In half of cases the patients present associate midline brain malformations of varying severity, the most frequent is the agenesia of the corpus callosus. The most accepted theory states that in embryonic phases, mesenchymal alterations at the level of the cranial sutures in the sagittal plane can cause anomalies of the SSS, sinus rectum, tentorium, and parietal bones that would explain the associated anomalies. Majority of intracranial lipomas are detected incidentally, being a third of the asymptomatic cases. As in all other pathologies certain localizations cause specific symptomatology of the involved area. The most common clinical manifestations are headache, epilepsy, mental dysfunctions and cranial nerve deficits. The clinical diagnosis is unclear and it is necessary release complementary exams in every suspected cases. Neuroimaging studies such as computed tomography (CT) or magnetic resonance imaging (MRI) make possible identify these lesions. We describe a clinical case about a 79-year-old woman with headache without any other symptoms. Was done CT and MRI that showed a inter-hemispheric lesion located in the pericallosal region, without any other abnormality associated. The development, during the last decades, of neuroimaging and histogenesis techniques increased the knowledge about this pathology and modified the management in recent times. The surgery is contraindicated in the majority of the cases, however still play a role in some cases especially in presence of hydrocephalus, uncontrollable seizures, and bony affectation with cosmetic influence. The medical control of the epilepsy is mandatory. We present a clinical case about pericallosal intracranial lipoma and review the current literature. Taking in account the clinical situation and the imaging findings, we decide for a conservative approach with clinical/neurological and radiological follow-up.
{"title":"A Clinical Case Report About an Intracranial Lipoma","authors":"Gonçalo Januário","doi":"10.11648/j.ijcocr.20230801.12","DOIUrl":"https://doi.org/10.11648/j.ijcocr.20230801.12","url":null,"abstract":": Intracranial lipoma is a uncommon congenital malformation, represent less than 0.1% of all intracranial tumors. Result from abnormal persistence and mal-differentiation of meninx primitiva, during embryogenesis. The cases in which the tumor presents an extracranial component are caused by a secondary dehiscence of the skull with evagination of a small tuft of primitive meninges. These lesions are frequently located in the inter-hemispheric fissure in the pericallosal region in 50% of cases, other locations as ambient or quadrigeminal cisterns present an incidence about 20-25%. In half of cases the patients present associate midline brain malformations of varying severity, the most frequent is the agenesia of the corpus callosus. The most accepted theory states that in embryonic phases, mesenchymal alterations at the level of the cranial sutures in the sagittal plane can cause anomalies of the SSS, sinus rectum, tentorium, and parietal bones that would explain the associated anomalies. Majority of intracranial lipomas are detected incidentally, being a third of the asymptomatic cases. As in all other pathologies certain localizations cause specific symptomatology of the involved area. The most common clinical manifestations are headache, epilepsy, mental dysfunctions and cranial nerve deficits. The clinical diagnosis is unclear and it is necessary release complementary exams in every suspected cases. Neuroimaging studies such as computed tomography (CT) or magnetic resonance imaging (MRI) make possible identify these lesions. We describe a clinical case about a 79-year-old woman with headache without any other symptoms. Was done CT and MRI that showed a inter-hemispheric lesion located in the pericallosal region, without any other abnormality associated. The development, during the last decades, of neuroimaging and histogenesis techniques increased the knowledge about this pathology and modified the management in recent times. The surgery is contraindicated in the majority of the cases, however still play a role in some cases especially in presence of hydrocephalus, uncontrollable seizures, and bony affectation with cosmetic influence. The medical control of the epilepsy is mandatory. We present a clinical case about pericallosal intracranial lipoma and review the current literature. Taking in account the clinical situation and the imaging findings, we decide for a conservative approach with clinical/neurological and radiological follow-up.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128121436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-19DOI: 10.11648/J.IJCOCR.20210604.11
Munkana Ndundula Arthur, Isango Idi Yves, Kasonga Kasonga Michel, Mushemuka Baleke Christian, K. Eric, Mwamba Mulumba Claude, Bakamwimba Kamwina Boaz, Tamubango Kitoko Hermann, Kakoma Sakatolo Zambèze, F. Véronique, Kalenga Prosper
Background: Human Papillomavirus (HPV) infection is the most common sexually transmitted infection in the world, particularly affecting people living with human immunodeficiency virus (HIV). A synergy between the two viruses is however described by several authors but very little is known in women living with HIV-HPV co-infection in Lubumbashi in the South of the Democratic Republic of Congo (DRC). Objective: The purpose of this study was to determine the prevalence of HPV infection in women living with HIV, to define the socio-demographic profile of HPV infection and to analyze certain clinical and paraclinical parameters. Methodology: A total of 77 women, including 58 HIV-infected women (group 1) and 19 HIV-free women (group 2), were included in a cross-sectional descriptive study that was conducted from November 01 to 30, 2019 at the HIV-AIDS Mother-Child Transmission Prevention Unit (MCTPU) of the Lubumbashi University Clinics (LUC). HPV was tested on cervical-vaginal secretions obtained either by self-sampling or by a sample taken by a previously trained examiner. HPV was investigated by the INNO-LIPA (PCR) method at the Microbiology, Bioorganic Chemistry and Macromolecular Unit laboratory of the Free University of Brussels in Belgium (FUB) while the diagnosis of HIV infection (PCR), viral load determination and CD4 level assay was performed in the LUC laboratory. Results: The overall frequency of HPV infection was 74.03%. It was significantly higher in HIV-infected women than in non-HIV-infected women (81.08% vs. 52.63%). The socio-demographic profile of the HPV-infected patient was made up of predominantly married, multi-parented women, aged on average 35, with a secondary education level and an average socio-economic level. Low monthly incomes and HIV infection were almost 4 times at risk for HPV infection (OR 4.2 [1,439-12,262] and OR 3.75 [1,269-11,080] respectively). Finally, HIV-positive patients infected with HPV had overall low levels of Lymphocyte T CD4 compared to those not infected with HPV. Conclusion: Our study shows that in Lubumbashi, HPV infection is present in both HIV-positive and negative women but its prevalence is distinctly higher in HIV-positive patients than those without HIV infection. It is interesting to determine in subsequent studies the different genotypes of HPV circulating in Lubumbashi and to define the proportion of genotypes at high carcinogenic risk.
{"title":"Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo","authors":"Munkana Ndundula Arthur, Isango Idi Yves, Kasonga Kasonga Michel, Mushemuka Baleke Christian, K. Eric, Mwamba Mulumba Claude, Bakamwimba Kamwina Boaz, Tamubango Kitoko Hermann, Kakoma Sakatolo Zambèze, F. Véronique, Kalenga Prosper","doi":"10.11648/J.IJCOCR.20210604.11","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210604.11","url":null,"abstract":"Background: Human Papillomavirus (HPV) infection is the most common sexually transmitted infection in the world, particularly affecting people living with human immunodeficiency virus (HIV). A synergy between the two viruses is however described by several authors but very little is known in women living with HIV-HPV co-infection in Lubumbashi in the South of the Democratic Republic of Congo (DRC). Objective: The purpose of this study was to determine the prevalence of HPV infection in women living with HIV, to define the socio-demographic profile of HPV infection and to analyze certain clinical and paraclinical parameters. Methodology: A total of 77 women, including 58 HIV-infected women (group 1) and 19 HIV-free women (group 2), were included in a cross-sectional descriptive study that was conducted from November 01 to 30, 2019 at the HIV-AIDS Mother-Child Transmission Prevention Unit (MCTPU) of the Lubumbashi University Clinics (LUC). HPV was tested on cervical-vaginal secretions obtained either by self-sampling or by a sample taken by a previously trained examiner. HPV was investigated by the INNO-LIPA (PCR) method at the Microbiology, Bioorganic Chemistry and Macromolecular Unit laboratory of the Free University of Brussels in Belgium (FUB) while the diagnosis of HIV infection (PCR), viral load determination and CD4 level assay was performed in the LUC laboratory. Results: The overall frequency of HPV infection was 74.03%. It was significantly higher in HIV-infected women than in non-HIV-infected women (81.08% vs. 52.63%). The socio-demographic profile of the HPV-infected patient was made up of predominantly married, multi-parented women, aged on average 35, with a secondary education level and an average socio-economic level. Low monthly incomes and HIV infection were almost 4 times at risk for HPV infection (OR 4.2 [1,439-12,262] and OR 3.75 [1,269-11,080] respectively). Finally, HIV-positive patients infected with HPV had overall low levels of Lymphocyte T CD4 compared to those not infected with HPV. Conclusion: Our study shows that in Lubumbashi, HPV infection is present in both HIV-positive and negative women but its prevalence is distinctly higher in HIV-positive patients than those without HIV infection. It is interesting to determine in subsequent studies the different genotypes of HPV circulating in Lubumbashi and to define the proportion of genotypes at high carcinogenic risk.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"316 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115917759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-18DOI: 10.11648/J.IJCOCR.20210603.17
M. McKay, Aaron Chindewere, L. Wise, Fraser Brown, K. Taubman, Timothy M McKay
The significant cancer pain syndrome of malignant psoas syndrome (MPS), was first reported as a neurooncologic occurrence in 1990. The Syndrome is characterised by malignant infiltration of a psoas muscle, either directly or by involvement with haematogenously disseminated metastatic cancer. Direct involvement has been from primary tumours of the psoas muscle, or by extension from malignant paraaortic lymphadenopathy. Treatment is difficult, complex analgesia is essential, and benefits have been achieved from chemotherapy, radiotherapy and in select cases, surgery. Here, the case of a 60 year old female who presented with three months of moderate dyspnoea, low back and left inguinal region pain/numbness and lassitude, is reported. Chest radiograph and CT showed a large anterior mediastinal mass. FDG PET/CT revealed the mass to be intensely avid, with heterogeneous central areas of photopaenia. Avid lymphadenopathy was also present in two mediastinal nodal stations. Subdiaphragmatically, there was a metabolically FDG avid soft tissue mass in the superior part of the left psoas muscle, presumably accounting for her pain. There was no FDG avidity elsewhere. Core biopsy of the psoas mass revealed adenocarcinoma of probable lung origin. The patient responded symptomatically to intermediate dose radiation therapy. The pathophysiology of MPS is discussed and the range of cancer types associated with the Syndrome is updated.
{"title":"Malignant Psoas Syndrome Demonstrated by PET/CT in the Context of Metastatic Non Small Cell Lung Cancer","authors":"M. McKay, Aaron Chindewere, L. Wise, Fraser Brown, K. Taubman, Timothy M McKay","doi":"10.11648/J.IJCOCR.20210603.17","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210603.17","url":null,"abstract":"The significant cancer pain syndrome of malignant psoas syndrome (MPS), was first reported as a neurooncologic occurrence in 1990. The Syndrome is characterised by malignant infiltration of a psoas muscle, either directly or by involvement with haematogenously disseminated metastatic cancer. Direct involvement has been from primary tumours of the psoas muscle, or by extension from malignant paraaortic lymphadenopathy. Treatment is difficult, complex analgesia is essential, and benefits have been achieved from chemotherapy, radiotherapy and in select cases, surgery. Here, the case of a 60 year old female who presented with three months of moderate dyspnoea, low back and left inguinal region pain/numbness and lassitude, is reported. Chest radiograph and CT showed a large anterior mediastinal mass. FDG PET/CT revealed the mass to be intensely avid, with heterogeneous central areas of photopaenia. Avid lymphadenopathy was also present in two mediastinal nodal stations. Subdiaphragmatically, there was a metabolically FDG avid soft tissue mass in the superior part of the left psoas muscle, presumably accounting for her pain. There was no FDG avidity elsewhere. Core biopsy of the psoas mass revealed adenocarcinoma of probable lung origin. The patient responded symptomatically to intermediate dose radiation therapy. The pathophysiology of MPS is discussed and the range of cancer types associated with the Syndrome is updated.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115494920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.11648/J.IJCOCR.20210603.16
H. Zubery, M. Shirin, F. Rahman, B. Bhowmik, M. Ibrahim, Z. Sultana
Accurate staging of patients with cervical carcinoma is crucial for appropriate management planning and tumor size has consistently been a key component & major determinant when deciding management plan in especially with early-stages as it dictates whether a patient is a candidate for conservative surgery, radical hysterectomy or chemoradiation. Tumor size also provides a prognostic value, as larger tumors predict risk for distant spread of disease and poor prognostic outcomes. The objective of this study was to determine the sensitivity and specificity of Magnetic Resonance Imaging in the measurement of actual tumor size of invasive cervical carcinoma in comparison to pelvic examination taking histopathology as gold standard. This prospective cross sectional study was conducted in the Department of Radiology and Imaging, BSMMU, Dhaka during the period of September 2018 to August 2020. A total of 60 patients were selected purposively and all were undergone pelvic examination clinically by EUA. Then all of them underwent MRI in Department of Radiology and Imaging, BSMMU. Images of uterine cervix, corpus, vagina and parametrium are taken with a prefixed standard protocol and reporting was done by Radiologist. Comparison was done between the MRI and clinical assessment of actual tumour size. Out of 60 patients in this study the mean age was found 47.5±10.1 years with range from 22 to 60 years. Positive correlation (r=0.993; p=0.001) between histopathological size and MRI size of tumour. Positive correlation (r=0.950; p=0.001) between histopathological size and FIGO size of tumour. MRI findings more correlates with histopathology than clinically detected tumor size. Based on pathologic findings, accuracy was estimated by the degree of agreement with a difference of <0.5 or 1.0 cm between the measurements of tumor size obtained by pelvic examination and imaging modality. Pelvic examination and imaging modality had an accuracy of 53.3% and 75%, respectively, with a difference of <0.5 cm, and an accuracy of 88.3% and 100%, respectively, with a difference of 0.5-1.0 cm. The study also concluded MRI staging was more concordant with pathological stage compared to the clinical stage. Concordance rate of 95.0% in MRI and 65.0% in clinical staging respectively. FIGO staging concurred with histopathology in 39 (65.0%) cases and differed in 21 (35.0%) cases. Magnetic resonance imaging (MRI) is a sensitive and specific modality for accurate determination of tumour size as well as staging of cervical carcinoma in comparison to pelvic examination taking histopathology as gold standard.
{"title":"Accuracy of Multiplanar MR Images in Determination of Actual Tumour Size in Comparison to the Pelvic Examination of Carcinoma Cervix","authors":"H. Zubery, M. Shirin, F. Rahman, B. Bhowmik, M. Ibrahim, Z. Sultana","doi":"10.11648/J.IJCOCR.20210603.16","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210603.16","url":null,"abstract":"Accurate staging of patients with cervical carcinoma is crucial for appropriate management planning and tumor size has consistently been a key component & major determinant when deciding management plan in especially with early-stages as it dictates whether a patient is a candidate for conservative surgery, radical hysterectomy or chemoradiation. Tumor size also provides a prognostic value, as larger tumors predict risk for distant spread of disease and poor prognostic outcomes. The objective of this study was to determine the sensitivity and specificity of Magnetic Resonance Imaging in the measurement of actual tumor size of invasive cervical carcinoma in comparison to pelvic examination taking histopathology as gold standard. This prospective cross sectional study was conducted in the Department of Radiology and Imaging, BSMMU, Dhaka during the period of September 2018 to August 2020. A total of 60 patients were selected purposively and all were undergone pelvic examination clinically by EUA. Then all of them underwent MRI in Department of Radiology and Imaging, BSMMU. Images of uterine cervix, corpus, vagina and parametrium are taken with a prefixed standard protocol and reporting was done by Radiologist. Comparison was done between the MRI and clinical assessment of actual tumour size. Out of 60 patients in this study the mean age was found 47.5±10.1 years with range from 22 to 60 years. Positive correlation (r=0.993; p=0.001) between histopathological size and MRI size of tumour. Positive correlation (r=0.950; p=0.001) between histopathological size and FIGO size of tumour. MRI findings more correlates with histopathology than clinically detected tumor size. Based on pathologic findings, accuracy was estimated by the degree of agreement with a difference of <0.5 or 1.0 cm between the measurements of tumor size obtained by pelvic examination and imaging modality. Pelvic examination and imaging modality had an accuracy of 53.3% and 75%, respectively, with a difference of <0.5 cm, and an accuracy of 88.3% and 100%, respectively, with a difference of 0.5-1.0 cm. The study also concluded MRI staging was more concordant with pathological stage compared to the clinical stage. Concordance rate of 95.0% in MRI and 65.0% in clinical staging respectively. FIGO staging concurred with histopathology in 39 (65.0%) cases and differed in 21 (35.0%) cases. Magnetic resonance imaging (MRI) is a sensitive and specific modality for accurate determination of tumour size as well as staging of cervical carcinoma in comparison to pelvic examination taking histopathology as gold standard.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125419294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.11648/J.IJCOCR.20210603.15
S. Noepel-Duennebacke, H. Juette, C. Lugnier, D. Modest, U. Martens, R. Klaassen-Mielke, V. Heinemann, T. Seufferlein, M. Geissler, A. Tannapfel, A. Reinacher-Schick, I. Tischoff
Aim: The VOLFI trial demonstrated an improved objective response rate through the addition of panitumumab to FOLFOXIRI in untreated all-RAS-wildtype mCRCs compared to FOLFOXIRI alone. In this subgroup analysis, we focused on histopathological response as a predictive marker for PFS. Additionally, we analyzed chemotherapy induced steatosis hepatitis (CASH) in both treatment arms. Methods: Histopathological response, CASH, sinusoidal obstructive syndrome, ballooning, steatosis, cholestasis, fibrosis and inflammation were determined in 14 resected liver metastasis. PFS was estimated using Kaplan-Meier method, the logrank test was used for the statistical comparison. The trial is registered with Clinical Trials. gov, NCT01328171. Results: Tissue of 14/18 resected pts. was evaluable. Median age was 57.5 yrs. (32–67), 7 male and 7 females. All primary tumors were located in the left colon. Molecular analysis detected one BRAF V600E mutation and one MSI-H tumor. Median treatment duration until resection were 7 cycles (3 – 12) panitumumab/mFOLFOXIRI and 9.5 cycles (7 - 11) FOLFOXIRI. 7 pts. achieved very good histopathological response corresponding to ≤20% vital tumor cells (panitumumab/ mFOLFOXIRI vs. FOLFOXIRI 2/5) and 7 pts. showed vital tumor cells >20% (panitumumab/mFOLFOXIRI vs. FOLFOXIRI 2/5). A very good histopathological response (residual tumor cells in proportion to the total tumor area ≤20%) showed a trend to an improved PFS in comparison to >20% (median PFS 12.40; 95% CI 6.43-51.22 vs. PFS 9.88; 95% CI 6.17-15.26 months). The severity of CASH was not increased by the addition of panitumumab or longer duration of chemotherapy. Discussion: In this analysis histopathological response seems to correlate with a better PFS after secondary metastasis resection. By analysis of liver toxicity, no relevant difference of CASH were detectable regarding panitumumab/mFOLFOXIRI vs. FOLFOXIRI or the duration of chemotherapy.
目的:VOLFI试验表明，与单独使用FOLFOXIRI相比，在未治疗的all-RAS-wildtype mccrcs中，通过将帕尼单抗加入FOLFOXIRI，客观缓解率有所提高。在这个亚组分析中，我们关注组织病理反应作为PFS的预测指标。此外，我们分析了两个治疗组中化疗诱导的脂肪变性肝炎(CASH)。方法:观察14例肝转移切除患者的组织病理反应、CASH、窦状动脉阻塞综合征、水肿、脂肪变性、胆汁淤积、纤维化和炎症。PFS采用Kaplan-Meier法估计，统计学比较采用logrank检验。该试验已在临床试验中注册。州长,NCT01328171。结果:14/18的组织被切除。可评价的。中位年龄为57.5岁。(32-67)，男7名，女7名。所有原发肿瘤均位于左结肠。分子分析检测到1例BRAF V600E突变和1例MSI-H肿瘤。panitumumab/mFOLFOXIRI的中位治疗时间为7个周期(3 - 12)，FOLFOXIRI为9.5个周期(7 - 11)。7分。获得了非常好的组织病理学反应，对应于≤20%的重要肿瘤细胞(panitumumab/ mFOLFOXIRI vs FOLFOXIRI 2/5)和7例。显示存活肿瘤细胞>20% (panitumumab/mFOLFOXIRI vs. FOLFOXIRI 2/5)。非常好的组织病理学反应(残余肿瘤细胞占肿瘤总面积的比例≤20%)表明，与>20%相比，PFS有改善的趋势(中位PFS 12.40;95% CI 6.43-51.22, PFS 9.88;95% CI 6.17-15.26个月)。CASH的严重程度不会因帕尼单抗的增加或化疗时间的延长而增加。讨论:在本分析中，组织病理反应似乎与继发性转移切除后较好的PFS相关。通过肝毒性分析，在panitumumab/mFOLFOXIRI与FOLFOXIRI或化疗时间方面，没有检测到CASH的相关差异。
{"title":"Histopathologic Regression and Survival in RAS Wildtype Metastatic Colorectal Cancer Under First-Line Treatment – Subgroup Analysis of the VOLFI Trial (AIO-KRK-0109)","authors":"S. Noepel-Duennebacke, H. Juette, C. Lugnier, D. Modest, U. Martens, R. Klaassen-Mielke, V. Heinemann, T. Seufferlein, M. Geissler, A. Tannapfel, A. Reinacher-Schick, I. Tischoff","doi":"10.11648/J.IJCOCR.20210603.15","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210603.15","url":null,"abstract":"Aim: The VOLFI trial demonstrated an improved objective response rate through the addition of panitumumab to FOLFOXIRI in untreated all-RAS-wildtype mCRCs compared to FOLFOXIRI alone. In this subgroup analysis, we focused on histopathological response as a predictive marker for PFS. Additionally, we analyzed chemotherapy induced steatosis hepatitis (CASH) in both treatment arms. Methods: Histopathological response, CASH, sinusoidal obstructive syndrome, ballooning, steatosis, cholestasis, fibrosis and inflammation were determined in 14 resected liver metastasis. PFS was estimated using Kaplan-Meier method, the logrank test was used for the statistical comparison. The trial is registered with Clinical Trials. gov, NCT01328171. Results: Tissue of 14/18 resected pts. was evaluable. Median age was 57.5 yrs. (32–67), 7 male and 7 females. All primary tumors were located in the left colon. Molecular analysis detected one BRAF V600E mutation and one MSI-H tumor. Median treatment duration until resection were 7 cycles (3 – 12) panitumumab/mFOLFOXIRI and 9.5 cycles (7 - 11) FOLFOXIRI. 7 pts. achieved very good histopathological response corresponding to ≤20% vital tumor cells (panitumumab/ mFOLFOXIRI vs. FOLFOXIRI 2/5) and 7 pts. showed vital tumor cells >20% (panitumumab/mFOLFOXIRI vs. FOLFOXIRI 2/5). A very good histopathological response (residual tumor cells in proportion to the total tumor area ≤20%) showed a trend to an improved PFS in comparison to >20% (median PFS 12.40; 95% CI 6.43-51.22 vs. PFS 9.88; 95% CI 6.17-15.26 months). The severity of CASH was not increased by the addition of panitumumab or longer duration of chemotherapy. Discussion: In this analysis histopathological response seems to correlate with a better PFS after secondary metastasis resection. By analysis of liver toxicity, no relevant difference of CASH were detectable regarding panitumumab/mFOLFOXIRI vs. FOLFOXIRI or the duration of chemotherapy.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133653469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.11648/J.IJCOCR.20210603.13
J. N. Malanda, Roland B. Banga-Mouss, Chellet Bilquis Bambi, Aubièrge Victoire Kimpamboudi Matondo, Inès Frédérique Nsondé Mondzié, B. Ngouaka, Siméon Stéphane Moubié
Considered as taboo, sexual difficulties and couple intimacy remain rarely tackled by patients and again less by the oncologist practicians. It might seem that faced with the vital stake of disease, this kind of worries seem to be frivolous, indeed shameful to be tackled. The current study had an objective to assess the impacts of cancer on male sexuality followed and treated in medical service in University Hospital of Brazzaville. Studying male sexual disorder of patients with cancer in medical oncology service in university hospital of Brazzaville. It was a retrospective study, from April 1st to July 31st 2018. All patients with cancer aged at least 18 years old with a performance of WHO between 0-2 were included. About one hundred (100) patients we examined whose eighty four (84) men, it appears that the most sexual disorder found is the one of craving, then the one of orgasm. Certain troubles had a link with the onset of cancer (p<5). The men presented a great number of sexual disorder had a cancer of digestive type (47.6%), urogenital (22.6%) and soft tissue (19%). In terms of received treatments: surgery-chemotherapy (men 22%), chemotherapy only (21.4%), surgery only (19%). The global frequency of sexual disorders to all patients is 98.4% in medical oncology service. It is important to consider those sexual disorders at the time of the care of those patients according to their repercussion on life quality during and after all treatment even in the absence of all progressive nature of disease. The most sexual disorder found is the one of craving.
{"title":"Male Sexual Disorders of Patients with Cancer in Medical Oncology Service in University Hospital of Brazzaville","authors":"J. N. Malanda, Roland B. Banga-Mouss, Chellet Bilquis Bambi, Aubièrge Victoire Kimpamboudi Matondo, Inès Frédérique Nsondé Mondzié, B. Ngouaka, Siméon Stéphane Moubié","doi":"10.11648/J.IJCOCR.20210603.13","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210603.13","url":null,"abstract":"Considered as taboo, sexual difficulties and couple intimacy remain rarely tackled by patients and again less by the oncologist practicians. It might seem that faced with the vital stake of disease, this kind of worries seem to be frivolous, indeed shameful to be tackled. The current study had an objective to assess the impacts of cancer on male sexuality followed and treated in medical service in University Hospital of Brazzaville. Studying male sexual disorder of patients with cancer in medical oncology service in university hospital of Brazzaville. It was a retrospective study, from April 1st to July 31st 2018. All patients with cancer aged at least 18 years old with a performance of WHO between 0-2 were included. About one hundred (100) patients we examined whose eighty four (84) men, it appears that the most sexual disorder found is the one of craving, then the one of orgasm. Certain troubles had a link with the onset of cancer (p<5). The men presented a great number of sexual disorder had a cancer of digestive type (47.6%), urogenital (22.6%) and soft tissue (19%). In terms of received treatments: surgery-chemotherapy (men 22%), chemotherapy only (21.4%), surgery only (19%). The global frequency of sexual disorders to all patients is 98.4% in medical oncology service. It is important to consider those sexual disorders at the time of the care of those patients according to their repercussion on life quality during and after all treatment even in the absence of all progressive nature of disease. The most sexual disorder found is the one of craving.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133813895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The solitary fibrous tumor is a benign mesenchymal tumor of rare extra-pleural location. We report a case of solitary fibrous tumor observed in the lower rectum simulating cancer. The objective was to discuss the diagnostic and therapeutic management of the solitary fibrous in Madagascar. Observation: This is a sixty-five-year-old man, seen in consultation for dyskinesia, with no family history of neoplasia. The digital rectal examination revealed a large, non-budding, firm mass at the level of the right posterolateral surface with a lower pole located 2 cm from the anal margin, the remains of the physical examination are normal. Abdominal computed tomography showed a mass measuring 8 × 7 × 5.5 cm at the expense of the rectal wall of regular tissue density, without a mesenteric node or secondary localization. the biopsy had not found any malignant cells. This result is due to insufficiently deep biopsy samples of the mass, which led us to perform a complete surgical excision by coloprotectomy. The operative follow-up to which was simple. Immunohistochemical study of the surgical specimen confirmed the diagnosis with a positive CD 34 marker. The outcome was favourable without metastasis or recurrence after a six-month follow-up. Conclusion: The rectal localization of the solitary fibrous tumor is exceptional. The diagnosis is histological confirmed by the immunohistochemical study with a positive CD 34 marker.
{"title":"Solitary Fibrous Tumor Low Rectum Simulating Cancer","authors":"Rajaonarivony Tianarivelo, Mosa Fasoa, Andrianarijon Heritiana Nandrianina, Rakotomena Solonirina Davidà, Rahantasoa Finaritra Casimir Fleur Prudence, Rakotonarivo Nirina","doi":"10.11648/J.IJCOCR.20210603.12","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210603.12","url":null,"abstract":"Introduction: The solitary fibrous tumor is a benign mesenchymal tumor of rare extra-pleural location. We report a case of solitary fibrous tumor observed in the lower rectum simulating cancer. The objective was to discuss the diagnostic and therapeutic management of the solitary fibrous in Madagascar. Observation: This is a sixty-five-year-old man, seen in consultation for dyskinesia, with no family history of neoplasia. The digital rectal examination revealed a large, non-budding, firm mass at the level of the right posterolateral surface with a lower pole located 2 cm from the anal margin, the remains of the physical examination are normal. Abdominal computed tomography showed a mass measuring 8 × 7 × 5.5 cm at the expense of the rectal wall of regular tissue density, without a mesenteric node or secondary localization. the biopsy had not found any malignant cells. This result is due to insufficiently deep biopsy samples of the mass, which led us to perform a complete surgical excision by coloprotectomy. The operative follow-up to which was simple. Immunohistochemical study of the surgical specimen confirmed the diagnosis with a positive CD 34 marker. The outcome was favourable without metastasis or recurrence after a six-month follow-up. Conclusion: The rectal localization of the solitary fibrous tumor is exceptional. The diagnosis is histological confirmed by the immunohistochemical study with a positive CD 34 marker.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"313 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124444962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-09DOI: 10.11648/J.IJCOCR.20210603.11
N. Okunnuga, A. Okunnuga, S. Osho, P. Osho, O. Olubosede
Background: Breast cancer is the commonest cancer found amongst women in Nigeria. It is a major cause of cancer mortality. The prevalence and presentation of breast cancer varies with the Socio-demographic pattern. The stage at presentation also determines the outcome. The burden of Breast cancer is high among women of all age groups in Nigeria. The prevalence of Breast cancer among women in Ondo state South West Nigeria is increasing and majority of the women present in the advance form of the disease. Objectives: To determine the Prevalence, stage and Sociodemographic factors associated with Breast Cancer. Method: The study is a retrospective analysis of clinical records of confirmed breast cancer patients between March 2013 and April 2019 attending the Oncology outpatient clinic at University of Medical Science Teaching Hospital, Akure, Ondo state Nigeria. The socio-demographic data were collated and analyzed. Results: A total of Four hundred breast cancer patients were seen. Their ages ranged from 20 to 89 years with a (mean age of 48.4 +/- 12.9 years). The Median age of 49.4 years. 99% were females and majority (68%) was premenopausal. Those younger than 40 years constituted 37.5% of the sample population while those older constituted 74.5%. The peak age of incidence was in the 4th decade. Majority of the participants 53.2% completed secondary education and 43% of the population had stage 4 disease. Conclusion: Breast cancer is the commonest cancer in women. The level of education does not correlate with a better knowledge of the disease and majority of the women presented with advance stage of the disease.
{"title":"Prevalence, Stage and Sociodemographic Pattern of Breast Cancer in a Tertiary Health Institution, South West Nigeria","authors":"N. Okunnuga, A. Okunnuga, S. Osho, P. Osho, O. Olubosede","doi":"10.11648/J.IJCOCR.20210603.11","DOIUrl":"https://doi.org/10.11648/J.IJCOCR.20210603.11","url":null,"abstract":"Background: Breast cancer is the commonest cancer found amongst women in Nigeria. It is a major cause of cancer mortality. The prevalence and presentation of breast cancer varies with the Socio-demographic pattern. The stage at presentation also determines the outcome. The burden of Breast cancer is high among women of all age groups in Nigeria. The prevalence of Breast cancer among women in Ondo state South West Nigeria is increasing and majority of the women present in the advance form of the disease. Objectives: To determine the Prevalence, stage and Sociodemographic factors associated with Breast Cancer. Method: The study is a retrospective analysis of clinical records of confirmed breast cancer patients between March 2013 and April 2019 attending the Oncology outpatient clinic at University of Medical Science Teaching Hospital, Akure, Ondo state Nigeria. The socio-demographic data were collated and analyzed. Results: A total of Four hundred breast cancer patients were seen. Their ages ranged from 20 to 89 years with a (mean age of 48.4 +/- 12.9 years). The Median age of 49.4 years. 99% were females and majority (68%) was premenopausal. Those younger than 40 years constituted 37.5% of the sample population while those older constituted 74.5%. The peak age of incidence was in the 4th decade. Majority of the participants 53.2% completed secondary education and 43% of the population had stage 4 disease. Conclusion: Breast cancer is the commonest cancer in women. The level of education does not correlate with a better knowledge of the disease and majority of the women presented with advance stage of the disease.","PeriodicalId":158614,"journal":{"name":"International Journal of Clinical Oncology and Cancer Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133563539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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