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Effect Of Roselle Petal Extract On Decreased Levels Of Mda In Rats With Type 2 Diabetes Roselle花瓣提取物对降低2型糖尿病大鼠Mda水平的影响
Pub Date : 2021-02-26 DOI: 10.33086/JHS.V14I1.1688
Novera Herdiani, E. Wikurendra
Received: August, 10, 2020 Revised: September, 7, 2020 Available online: February, 2021 Diabetes mellitus type 2 is a metabolic disorder, namely a decrease in peripheral tissues' response to insulin. Free radicals increase, which results in the forming of Malondialdehyde (MDA). Roselle flower petals is an antioxidant to reduce free radical damage. This study aims to analyze the effect of roselle petal extract on decreased MDA levels in mice induced by diabetes. The rats were divided into four treatments group as follow: 1) control negative, 2) control positive, 3) treatment dose I (administering roselle petal extract 195 mg/200 gram body weight), 4) treatment dose II (giving roselle petal extract 260mg/ 200 gram body weight). MDA levels were measured using Thiobarbituric acid (TBA) assay. There was an effect of rosella petal extract in the group with 260 mg/200 of rosella petal extract (p=0.005) and 195 mg/200 of rosella petal extract (p=0.041) compared with the positive control group. Rosella petal extract significantly reduces MDA levels in rats induced by type 2 diabetes.
2型糖尿病是一种代谢性疾病,即外周组织对胰岛素的反应降低。自由基增加,导致丙二醛(MDA)的形成。玫瑰花瓣是一种抗氧化剂,可以减少自由基的伤害。本研究旨在分析玫瑰花瓣提取物对糖尿病小鼠MDA水平降低的影响。将大鼠分为4个处理组,分别为:1)对照阴性组,2)对照阳性组,3)处理1(给予玫瑰花瓣提取物195 mg/200 g体重),4)处理2(给予玫瑰花瓣提取物260mg/ 200 g体重)。采用硫代巴比妥酸(TBA)法测定丙二醛水平。玫瑰花瓣提取物260 mg/200 (p=0.005)和195 mg/200 (p=0.041)组与阳性对照组相比,效果显著。迷迭香花瓣提取物可显著降低2型糖尿病大鼠的丙二醛水平。
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引用次数: 1
Combination of Storytelling and Music Therapy to Reduce Stress in Children with HIV/AIDS and Discrimination in Surabaya 结合讲故事和音乐疗法来减少艾滋病毒/艾滋病儿童的压力和泗水的歧视
Pub Date : 2021-02-26 DOI: 10.33086/JHS.V14I1.1749
Taufan Citra Darmawan
Received: September, 1, 2020 Revised: November, 7, 2020 Available online: February, 2021 Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) in Indonesia are deadly infectious diseases. This disease will always be a problem at the national and global levels. The impact that often occurs, especially in children with HIV/AIDS, is psychological changes, namely stress. Efforts to overcome its disturbance are storytelling and music therapy. This research aims to apply storytelling and music therapy to reduce stress in children with HIV/AIDS. This research method was a quasi-experiment with a research design involving 1 group (one group pre-posttest), containing 30 respondents aged 6-10 years with HIV/AIDS by purposive sampling. The independent variable was storytelling and music therapy, while the dependent variable was stress levels. The instrument used Hamilton Anxiety Questionaire (HAM-A). The results of the study showed that 26 samples (86.7%) experienced decreased stress levels. Analysis of Wilcoxon sign rank test obtained α=0.009, which means there was a difference before and after therapy. The combination of music therapy and storytelling can be a better alternative in reducing stress in children – by considering age, environment, and children's emotions to have an optimal effect).
收稿日期:2020年9月1日修稿日期:2020年11月7日在线出版日期:2021年2月人类免疫缺陷病毒(HIV)和获得性免疫缺陷综合征(AIDS)在印度尼西亚是致命的传染病。这种疾病将永远是国家和全球一级的一个问题。特别是在感染艾滋病毒/艾滋病的儿童中,经常发生的影响是心理变化,即压力。克服它的方法是讲故事和音乐疗法。本研究旨在应用讲故事和音乐疗法来减轻艾滋病儿童的压力。本研究方法为准实验研究设计,采用目的抽样法,共纳入30名6-10岁HIV/AIDS感染者,研究设计为1组(前-后测组)。自变量是讲故事和音乐治疗,因变量是压力水平。量表采用汉密尔顿焦虑问卷(HAM-A)。研究结果显示,26个样本(86.7%)的压力水平有所下降。经Wilcoxon符号秩检验分析得到α=0.009,表示治疗前后有差异。音乐疗法和讲故事的结合是减轻儿童压力的一个更好的选择——通过考虑年龄、环境和儿童的情绪来达到最佳效果)。
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引用次数: 1
The Role Of Corticosteroid Administration On The Incidents Of Asphyxia Neonatorum Among Mothers With Preterm Delivery In Ponek Rsud Jombang 皮质类固醇给药在Ponek Rsud jjbang地区早产母亲新生儿窒息发生率中的作用
Pub Date : 2021-02-26 DOI: 10.33086/JHS.V14I1.1297
R. Lestari, Niken Grah Prihartanti, Mamik Ratnawati
Received: September, 5, 2020 Revised: December, 2, 2020 Available online: February, 2021 The causes of death for newborns 0-6 days in Indonesia are 36.9% respiratory disorders, 32.4% premature birth, 12% sepsis, 6.8% hypothermia, and 6.6% neonatal jaundice. A preliminary study in Comprehensive Emergency Services Neonatal Obstetric (PONEK) of Jombang Regional Public Hospital (RSUD Jombang) reported that the incidence of asphyxia neonatorum was 295 cases in 2016 and 341 cases in 2015. There were 98 cases of preterm delivery in 2016. This study aims to prove the effect of corticosteroid administration on neonatal asphyxia in mothers with preterm delivery. This study was an analytical study using a one-group after only design. The population was all women giving birth at RSUD Jombang with preterm labor diagnosis in January-May 2017, while the sample was 82. The instruments utilized questionnaires and checklists. The bivariate analysis applied the chi-square association test. Based on the results of the chisquare test χ2= 4.622> χ2 table; p = 0.009 <α (0.05). There was a correlation between corticosteroid administration and the incidence of asphyxia neonatorum in women with preterm delivery. This study's results could be an input for primary health care facilities to prevent neonatal asphyxia. Further research should develop other similar variables and increase the number of respondents.
印尼0-6天新生儿死亡原因中,呼吸系统疾病占36.9%,早产占32.4%,败血症占12%,低温症占6.8%,新生儿黄疸占6.6%。据Jombang地区公立医院(RSUD Jombang)新生儿产科综合急诊服务(PONEK)的初步研究报告,2016年新生儿窒息发生率为295例,2015年为341例。2016年有98例早产。本研究旨在证明皮质类固醇药物对早产母亲新生儿窒息的影响。本研究为单组分析性研究。人群为2017年1月至5月在RSUD Jombang分娩并诊断为早产的所有妇女,样本为82人。这些工具使用调查表和清单。双变量分析采用卡方关联检验。根据χ2= 4.622> χ2表的结果;P = 0.009 <α(0.05)。存在皮质类固醇给药与早产妇女新生儿窒息发生率之间的相关性。本研究结果可为初级卫生保健机构预防新生儿窒息提供参考。进一步的研究应该开发其他类似的变量,并增加受访者的数量。
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引用次数: 0
Development Of Stunted Toddlers Aged 24-59 Months Using Prescreening Developmental Questionnaire (Pdq) In Air Dingin Public Health Center, Padang 2019: An Overview 巴东市定宁市公共卫生中心2019年24-59月龄发育迟缓幼儿发展预筛查问卷(Pdq)调查综述
Pub Date : 2021-02-26 DOI: 10.33086/JHS.V14I1.1447
D. Hasni, Febianne Eldrian, Anjas Adisena
Received: January, 24, 2020 Revised: April, 17, 2020 Available online: February, 2021 Stunting is a chronic malnutrition problem that resulted from an insufficient nutritional intake for a long time. This problem can develop during pregnancy, infancy, childhood, and throughout the life cycle due to feeding that does not accommodate the nutritional needs. Stunting correlates with disorders of fine motor, gross motor, language, and personal social skills. This study aims to perceive an overview of stunted toddlers aged 24-59 months using the Prescreening Developmental Questionnaire (PDQ). The authors carried out this research in Air Dingin public health center, Padang, from April to September 2019. This research was descriptive that included 40 toddlers aged 24-59 months diagnosed with stunting. The data presentation was a frequency distribution table and percentage. This study obtained that 22 toddlers (55.0%) were girls, seven toddlers (17.5%) experienced a developmental deviation, and 26 toddlers (65%) had suspected developmental deviation. In short, there were several cases of stunted toddlers who underwent a developmental deviation.
发育迟缓是由于长期营养摄入不足而导致的慢性营养不良问题。由于喂养不能满足营养需求,这个问题可以在怀孕、婴儿期、儿童期以及整个生命周期中发展。发育迟缓与精细运动、大运动、语言和个人社交技能障碍有关。本研究旨在利用发育预筛查问卷(PDQ)了解24-59月龄发育迟缓幼儿的概况。作者于2019年4月至9月在巴东航空定京公共卫生中心进行了这项研究。这项研究是描述性的,包括40名年龄在24-59个月之间被诊断为发育迟缓的幼儿。数据呈现为频率分布表和百分比。本研究得出22名幼儿为女孩(55.0%),7名幼儿(17.5%)存在发展偏差,26名幼儿(65%)存在疑似发展偏差。简而言之,有几例发育迟缓的幼儿经历了发育偏差。
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引用次数: 1
Surveillance Implementation Of Hiv/Aids In Jember Regency 艾滋病毒/艾滋病监测在十二月摄政的实施
Pub Date : 2021-02-26 DOI: 10.33086/JHS.V14I1.1646
Irma Prasetyowati, A. E. Noveyani, Ni'mal Baroya, Wahyu Martina Sari, Heni Nuraini, Abdulfeta Ali, Ana Masfurotin Ni’mah, Dena Anggraeni Harjanto
Received: July, 9, 2020 Revised: November, 12, 2020 Available online: February, 2021 The number of people living with HIV/AIDS in Indonesia is increasing every year. HIV/AIDS surveillance is the most effective way to control the spreading of HIV/AIDS cases. This study aims to describe the implementation of HIV/AIDS surveillance in Jember. This paper was a descriptive study that included all public health centers (PHCs) conducting HIV/AIDS surveillance. The sample was the Jember District Departement of Health Office and four PHCs using purposive sampling. Variables in this study were input, process, and output. The data was obtained from an interview using a questionnaire. The results indicated that the four PHCs did not have an epidemiologist. Data collection mostly derived from Voluntary Counseling and Testing (VCT) and mobile VCT. Processing HIV/AIDS surveillance data utilized the HIV/AIDS and STDs Information System (SIHA) application and validated by the District Department of Health Office once a month. However, only two PHCs conducted analysis and data interpretation. Dissemination was only done by the District Departement of Health Office and 2 out of 4 PHCs. Hence, the components and process of surveillance needed to be optimized.
收稿日期:2020年7月9日修稿日期:2020年11月12日可上网日期:2021年2月印度尼西亚的艾滋病毒/艾滋病感染者人数每年都在增加。艾滋病毒/艾滋病监测是控制艾滋病毒/艾滋病病例蔓延的最有效途径。本研究旨在描述艾滋病病毒/艾滋病监测的实施情况。本文是一项描述性研究,包括所有进行艾滋病毒/艾滋病监测的公共卫生中心(PHCs)。样本为琼伯区卫生署办事处和四个初级保健中心,采用有目的抽样。本研究的变量为输入、过程和输出。数据是通过问卷采访获得的。结果表明,这4家初级保健医院没有流行病学家。数据收集主要来自自愿咨询和测试(VCT)和移动VCT。利用艾滋病毒/艾滋病和性传播疾病信息系统(SIHA)应用程序处理艾滋病毒/艾滋病监测数据,并由区卫生署办事处每月验证一次。然而,只有两个初级保健中心进行了分析和数据解释。传播工作仅由区卫生局和4个初级保健中心中的2个进行。因此,需要优化监测的组成部分和过程。
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引用次数: 1
The Effectiveness Of Vernonia Amygdalina (African Bitter Leaf) Tea For Reducing Cholesterol Levels In Individuals With Hypercholesterolemia 苦杏仁茶降低高胆固醇血症患者胆固醇水平的有效性
Pub Date : 2021-02-25 DOI: 10.33086/JHS.V14I1.1759
Nunik Purwanti, R. Aditya
Received: September, 14, 2020 Revised: November 4, 2020 Available online: February 2021 Advances in technology and high activities at work cause a person to prefer fast food, increasing the risks of high cholesterol levels. Meanwhile, the healing of hypercholesterolemia requires a long treatment time. One of them is nonpharmacological treatment using Vernonia amygdalina (African bitter leaf) tea. This study analyzes V.amygdalina (African bitter leaf) effectiveness for reducing the cholesterol levels in individuals with hypercholesterolemia. The design of this study was a quasi-experimental design, with a non-equivalent control group design. The population involved individuals with hypercholesterolemia in the village of Kedensari RW 05 Tanggulangin, Sidoarjo. There were 40 respondents in this study using the purposive sampling technique – 20 respondents in the experimental group and 20 respondents in the control group. The independent variable was V.amygdalina tea, whereas the dependent variable was cholesterol levels. The data were analyzed using the Wilcoxon and Mann-Whitney tests. The p-value of the Wilcoxon test and MannWhitney signed-ranks test was (0.000)<α(0.005), which illustrated that V.amygdalina (African bitter leaf) tea was useful for the treatment of hypercholesterolemia.
收稿日期:2020年9月14日修订日期:2020年11月4日在线发布日期:2021年2月科技进步和高强度的工作活动使人们更喜欢快餐,增加了高胆固醇水平的风险。同时,高胆固醇血症的治愈需要较长的治疗时间。其中之一是非药物治疗使用苦杏仁茶(非洲苦叶)。本研究分析了苦杏仁叶(非洲苦叶)对降低高胆固醇血症患者胆固醇水平的有效性。本研究设计为准实验设计,采用非等效对照组设计。该人群涉及Sidoarjo的Kedensari rw05 Tanggulangin村的高胆固醇血症患者。本研究采用有目的抽样技术,共40名被调查者,实验组20名,对照组20名。自变量是苦杏仁茶,因变量是胆固醇水平。使用Wilcoxon和Mann-Whitney检验对数据进行分析。Wilcoxon检验和MannWhitney秩号检验的p值为(0.000)<α(0.005),说明苦叶茶对高胆固醇血症有治疗作用。
{"title":"The Effectiveness Of Vernonia Amygdalina (African Bitter Leaf) Tea For Reducing Cholesterol Levels In Individuals With Hypercholesterolemia","authors":"Nunik Purwanti, R. Aditya","doi":"10.33086/JHS.V14I1.1759","DOIUrl":"https://doi.org/10.33086/JHS.V14I1.1759","url":null,"abstract":"Received: September, 14, 2020 Revised: November 4, 2020 Available online: February 2021 Advances in technology and high activities at work cause a person to prefer fast food, increasing the risks of high cholesterol levels. Meanwhile, the healing of hypercholesterolemia requires a long treatment time. One of them is nonpharmacological treatment using Vernonia amygdalina (African bitter leaf) tea. This study analyzes V.amygdalina (African bitter leaf) effectiveness for reducing the cholesterol levels in individuals with hypercholesterolemia. The design of this study was a quasi-experimental design, with a non-equivalent control group design. The population involved individuals with hypercholesterolemia in the village of Kedensari RW 05 Tanggulangin, Sidoarjo. There were 40 respondents in this study using the purposive sampling technique – 20 respondents in the experimental group and 20 respondents in the control group. The independent variable was V.amygdalina tea, whereas the dependent variable was cholesterol levels. The data were analyzed using the Wilcoxon and Mann-Whitney tests. The p-value of the Wilcoxon test and MannWhitney signed-ranks test was (0.000)<α(0.005), which illustrated that V.amygdalina (African bitter leaf) tea was useful for the treatment of hypercholesterolemia.","PeriodicalId":15873,"journal":{"name":"Journal of Health Science","volume":"85 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90723316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Description Of Mothers' Motivation In Developmental Stimulation Of Children Aged 1 - 3 Years Old In Sambungrejo Village, Sidoarjo Sidoarjo Sambungrejo村1 - 3岁儿童发育刺激中母亲动机的描述
Pub Date : 2021-02-18 DOI: 10.33086/JHS.V14I1.1943
R. Anggraini, Wahyu Anjas Sari
Received: April, 19, 2020 Revised: September, 30, 2020 Available online: February, 2021 Children will grow faster when their mother stimulate their development. But in fact, parents' awareness is still low due to parents' reluctance. They believe that stimulation is for children with developmental delay. This research aims to describe the mothers' motivation in the developmental stimulation of children aged 1-3 years old in Sambungrejo Village District Sidoarjo. This study used a descriptive design. The population was mothers with children age 1–3 years in Sambungrejo Village Sukodono Sidoarjo. There were 50 respondents with simple random sampling. The research variable was mothers' motivation in the developmental stimulation of children aged 1-3 years. The instrument utilized a questionnaire. The data analysis was frequency distribution. The results showed that 62,5% of respondents had low motivation, while 37,5% of respondents had a high motive to perform stimulation in developing children aged 1–3. The study concludes that most mothers have low motivation in developmental stimulation. Health workers should give health education about the developmental stimulation of children to mothers.
收稿日期:2020年4月19日修稿日期:2020年9月30日上线日期:2021年2月母亲的刺激会让孩子成长得更快。但事实上,由于家长的不情愿,家长的意识仍然很低。他们认为刺激是为发育迟缓的儿童准备的。本研究旨在探讨Sidoarjo村三本格列乔村1-3岁儿童发育刺激的母亲动机。本研究采用描述性设计。人口是Sambungrejo村Sukodono Sidoarjo带着1-3岁孩子的母亲。调查对象为50人,采用简单随机抽样法。研究变量为母亲在1-3岁儿童发育刺激中的动机。该仪器采用问卷调查。数据分析采用频率分布。结果显示,在1-3岁的发展中儿童中,62.5%的被调查者表现出低动机,37.5%的被调查者表现出高动机。该研究的结论是,大多数母亲对发育刺激的积极性较低。卫生工作者应向母亲提供有关促进儿童发育的健康教育。
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引用次数: 0
Factors Affecting Toddlers' Development in Pamekasan Regency 影响帕梅卡桑县幼儿发展的因素
Pub Date : 2021-02-18 DOI: 10.33086/JHS.V14I1.1942
Nur Jayanti, Rohemah Rohemah, Uliyatul Laili
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引用次数: 1
Quality of Croatian Inland Bathing Areas: Reference to The Region and EU 克罗地亚内陆浴场的质量:对地区和欧盟的参考
Pub Date : 2021-02-15 DOI: 10.17532/JHSCI.2021.1110
D. Galic, A. Cenov, D. Lušić, M. Glad, Slaven Jozić, Bruno Cvetković, Daniel Maestro, N. Maestro, D. Mance, Darija Vukić Lušić
Introduction: The Republic of Croatia (HR) has significantly invested in monitoring the quality of inland bathing areas during the past 10 years. The aim of this paper was to analyze the results obtained during the 2014-2019 period and to compare them with the Region (non-European Union [EU] countries neighboring Croatia) and EU. Moreover, bathing water quality data at two bathing areas of Zagreb (lakes Jarun and Bundek) were processed in more detail.Methods: The quality of inland bathing areas in the HR is monitored in five rivers and five lakes in nine Croatian counties; 19 of the 35 monitored sites are located in Zagreb County. Escherichia coli (EC) was determined by EN ISO 9308-3: 1998, while intestinal enterococci (ENT) were defined by EN ISO 7899-2: 2000. Statistical processing of the results was performed using the Microsoft Excel Statistical Package (Redmond, USA) and Statistica 13.5. (Stat.Sof.Inc., Tulsa, USA); the significance level was set to p < 0.05.Results: During the study period, the worst Croatian inland water quality was recorded in 2019 (excellent quality for only 25.9% of the bathing areas), while the best quality was recorded in 2015 (excellent quality in 57.1%). On average (2014-2019), the share of bathing areas with excellent quality in Croatia was 46.3% (i.e., under the EU average of 85.3%); with no poor locations (EU average was nearly 2%). A significant positive correlation was found between fecal indicators (EC&ENT) and the amount of precipitation, while a negative correlation with water and air temperature in lakes.Conclusions: The quality of Croatian inland bathing areas is significantly lower than the European average, while EU water quality is improving. Regarding the countries bordering Croatia, Italy, Slovenia, and Hungary have achieved better results, while Montenegro, Serbia, and Bosnia and Herzegovina are still in the process of developing the monitoring of the bathing water quality.
导言:克罗地亚共和国(HR)在过去十年中为监测内陆浴场的质量投入了大量资金。本文的目的是分析2014-2019年期间获得的结果,并将其与该地区(克罗地亚邻国的非欧盟[EU]国家)和欧盟进行比较。此外,对萨格勒布两个洗浴区(Jarun湖和Bundek湖)的洗浴水质数据进行了更详细的处理。方法:对克罗地亚9个县的5条河流和5个湖泊进行内陆浴场水质监测;35个监测场址中有19个位于萨格勒布县。大肠杆菌(EC)测定方法采用EN ISO 9308- 3:20 98,肠球菌(ENT)测定方法采用EN ISO 7899- 2:20 00。使用Microsoft Excel Statistical Package (Redmond, USA)和Statistica 13.5对结果进行统计处理。(Stat.Sof.Inc。(塔尔萨,美国);显著性水平设为p < 0.05。结果:在研究期间,克罗地亚内陆水质最差的年份是2019年(只有25.9%的浴场水质优良),而最好的年份是2015年(57.1%的浴场水质优良)。平均而言(2014-2019年),克罗地亚优质浴场的比例为46.3%(即低于欧盟85.3%的平均水平);没有贫困地区(欧盟平均水平接近2%)。粪便指标(EC&ENT)与降水量呈显著正相关,与湖泊水温和气温呈显著负相关。结论:克罗地亚内陆浴场水质明显低于欧洲平均水平,而欧盟水质正在改善。在与克罗地亚接壤的国家中,意大利、斯洛文尼亚和匈牙利取得了较好的成果,而黑山、塞尔维亚和波斯尼亚和黑塞哥维那仍在开展洗浴水质监测工作。
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引用次数: 2
The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer 乳腺癌不同分子亚型肿瘤微环境与临床病理参数的关系
Pub Date : 2021-01-22 DOI: 10.17532/JHSCI.2021.1121
Nina Čamdžić, Suada Kuskunović-Vlahovljak, S. Radović, Mirsad Dorić, M. Babić, Edina Lazović Salčin, A. Spahić
Introduction: Tumor microenvironment plays a significant role in tumor progression. Tumor stroma is one of the strongest modifiers of tumor cell response, cancer behavior, and cancer progression. This study aimed to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and tumor-stroma ratio (TSR) with standard clinicopathological parameters in different molecular subtypes of breast cancer.Methods: Ninety biopsy samples of primary breast cancer diagnosed at the Department of Pathology, School of Medicine, Sarajevo, were selected for this study. The molecular subtype was determined based on the immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67. Stromal and tumoral MMP-9 immunohistochemical expression and the TSR were determined for each tumor.Results: Tumoral MMP-9 expression correlated positively with the presence of lymphovascular invasion (p= 0.016). TSR showed significant association and correlation with tumor grade (G) (p= 0.031; p= 0.049) and tumor size (pT) (p = 0.049;p= 0.021, respectively). Stromal MMP-9 expression correlated with histologic type, histologic grade of tumor, and lymphocytic inflammatory infiltrate (p= 0.021;p= 0.047, p= 0.038, respectively). A higher percentage of stromal MMP-9 expression correlated with the strongest lymphocytic response (p = 0.007). Significant correlation was observed between molecular subtypes and histologic grade of the tumor (p= 0.032).Conclusion: Our results, to some extent, confirm the significance of the tumor microenvironment in breast cancer, especially when it is about stromal MMP-9 expression. Although we observed significant association, without linear correlation, we found no significant correlation between molecular subtypes of breast cancer and MMP-9 expression.
肿瘤微环境在肿瘤进展中起着重要作用。肿瘤基质是肿瘤细胞反应、肿瘤行为和肿瘤进展的最强调节剂之一。本研究旨在探讨基质金属蛋白酶-9 (matrix metalloproteinase-9, MMP-9)表达、瘤间质比(tumor-stroma ratio, TSR)与乳腺癌不同分子亚型标准临床病理参数的相关性。方法:选取萨拉热窝医学院病理学系诊断的原发性乳腺癌90例活检标本进行研究。根据雌激素受体、孕激素受体、人表皮生长因子受体2和Ki-67的免疫组化表达确定分子亚型。测定各肿瘤间质和肿瘤MMP-9免疫组化表达及TSR。结果:肿瘤中MMP-9的表达与淋巴血管浸润呈正相关(p= 0.016)。TSR与肿瘤分级(G)有显著相关性(p= 0.031;p= 0.049)和肿瘤大小(pT) (p = 0.049;p= 0.021)。基质MMP-9表达与肿瘤的组织学类型、组织学分级、淋巴细胞炎性浸润相关(p= 0.021、p= 0.047、p= 0.038)。基质MMP-9表达比例越高,淋巴细胞反应越强烈(p = 0.007)。分子亚型与肿瘤的组织学分级有显著相关性(p= 0.032)。结论:我们的研究结果在一定程度上证实了肿瘤微环境在乳腺癌中的意义,特别是在基质MMP-9的表达方面。虽然我们观察到有显著相关性,但没有线性相关性,我们发现乳腺癌分子亚型与MMP-9的表达没有显著相关性。
{"title":"The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer","authors":"Nina Čamdžić, Suada Kuskunović-Vlahovljak, S. Radović, Mirsad Dorić, M. Babić, Edina Lazović Salčin, A. Spahić","doi":"10.17532/JHSCI.2021.1121","DOIUrl":"https://doi.org/10.17532/JHSCI.2021.1121","url":null,"abstract":"Introduction: Tumor microenvironment plays a significant role in tumor progression. Tumor stroma is one of the strongest modifiers of tumor cell response, cancer behavior, and cancer progression. This study aimed to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and tumor-stroma ratio (TSR) with standard clinicopathological parameters in different molecular subtypes of breast cancer.Methods: Ninety biopsy samples of primary breast cancer diagnosed at the Department of Pathology, School of Medicine, Sarajevo, were selected for this study. The molecular subtype was determined based on the immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67. Stromal and tumoral MMP-9 immunohistochemical expression and the TSR were determined for each tumor.Results: Tumoral MMP-9 expression correlated positively with the presence of lymphovascular invasion (p= 0.016). TSR showed significant association and correlation with tumor grade (G) (p= 0.031; p= 0.049) and tumor size (pT) (p = 0.049;p= 0.021, respectively). Stromal MMP-9 expression correlated with histologic type, histologic grade of tumor, and lymphocytic inflammatory infiltrate (p= 0.021;p= 0.047, p= 0.038, respectively). A higher percentage of stromal MMP-9 expression correlated with the strongest lymphocytic response (p = 0.007). Significant correlation was observed between molecular subtypes and histologic grade of the tumor (p= 0.032).Conclusion: Our results, to some extent, confirm the significance of the tumor microenvironment in breast cancer, especially when it is about stromal MMP-9 expression. Although we observed significant association, without linear correlation, we found no significant correlation between molecular subtypes of breast cancer and MMP-9 expression.","PeriodicalId":15873,"journal":{"name":"Journal of Health Science","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90469579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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