Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458055
Xuantao Su, Yan Yang, Xuming Sun, Xu Qiao, K. Song, B. Kong
Flow cytometry has wide applications in cell biology and medicine. Compared with conventional fluorescence labeling, light scattering can be adopted as a label-free cytometric method. Integration of optics with microfluidics, the optofluidic technology may help for the advancement of the next generation miniaturized label-free cytometry. Optofluidic label-free cytometry that can obtain two dimensional light scattering patterns from single cells has been developed. Laser light is fibered-coupled onto a microfluidic chip, and light scattering patterns can be obtained via a CMOS detector. Light scattering from cells or particles in such a cytometric setup can be simulated via the Mie theory or finite-difference time-domain (FDTD) method. The experimental results agree well with the simulated ones for yeast cells. Further development of the optofluidic label-free cytometric technique may help for early cancer screening, and provide portable instruments for clinics and home care.
{"title":"Miniaturized optofluidic label-free cytometry","authors":"Xuantao Su, Yan Yang, Xuming Sun, Xu Qiao, K. Song, B. Kong","doi":"10.1109/PGC.2012.6458055","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458055","url":null,"abstract":"Flow cytometry has wide applications in cell biology and medicine. Compared with conventional fluorescence labeling, light scattering can be adopted as a label-free cytometric method. Integration of optics with microfluidics, the optofluidic technology may help for the advancement of the next generation miniaturized label-free cytometry. Optofluidic label-free cytometry that can obtain two dimensional light scattering patterns from single cells has been developed. Laser light is fibered-coupled onto a microfluidic chip, and light scattering patterns can be obtained via a CMOS detector. Light scattering from cells or particles in such a cytometric setup can be simulated via the Mie theory or finite-difference time-domain (FDTD) method. The experimental results agree well with the simulated ones for yeast cells. Further development of the optofluidic label-free cytometric technique may help for early cancer screening, and provide portable instruments for clinics and home care.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116911121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458091
K. Dambul, G. Mahdiraji, F. Amirkhan, D. Chow, G. Gan, W. Wong, M. R. Abu Hassan, S. Ismail, S. A. Ibrahim, N. Tamchek, F. Adikan
This paper reports the parameters that affect the fabrication of Flat Fibers, including preform size and doping, furnace temperature, preform feed speed, fiber drawing speed, fiber dimension, fiber quality and shape, vacuum pressure and core dimension. The feed and draw speed generally follows the simplified mass conservation law to draw the fiber to a specific dimension. The preform wall thickness affects the vacuum pressure and furnace temperature that is needed to `flatten' the fiber. The preform wall thickness is directly proportional to the volume of glass inside the neck-down region. The wall thickness of the preform and its dopant will also affect the size of the cladding and core dimension. Finally, some issues associated with the fabrication of Flat Fibers are also observed and discussed, including fabrication of Flat Fibers with non-uniform dimensions, deformed shapes, unwanted airholes and poor quality of the Flat Fibers.
{"title":"Fabrication and development of Flat Fibers","authors":"K. Dambul, G. Mahdiraji, F. Amirkhan, D. Chow, G. Gan, W. Wong, M. R. Abu Hassan, S. Ismail, S. A. Ibrahim, N. Tamchek, F. Adikan","doi":"10.1109/PGC.2012.6458091","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458091","url":null,"abstract":"This paper reports the parameters that affect the fabrication of Flat Fibers, including preform size and doping, furnace temperature, preform feed speed, fiber drawing speed, fiber dimension, fiber quality and shape, vacuum pressure and core dimension. The feed and draw speed generally follows the simplified mass conservation law to draw the fiber to a specific dimension. The preform wall thickness affects the vacuum pressure and furnace temperature that is needed to `flatten' the fiber. The preform wall thickness is directly proportional to the volume of glass inside the neck-down region. The wall thickness of the preform and its dopant will also affect the size of the cladding and core dimension. Finally, some issues associated with the fabrication of Flat Fibers are also observed and discussed, including fabrication of Flat Fibers with non-uniform dimensions, deformed shapes, unwanted airholes and poor quality of the Flat Fibers.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123364484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458037
J. Kee, S. Lim, A. P. Perera, M. K. Park, Yong Zhang
We explore the optical biosensing platform in plasmonic nanoholes array. The periodic nanohole structure of the biosensor and the gold coating of the sensor surface produce extraordinary light transmission (EOT) resonances of which the resonance peak shifts proportionately to the change of environment refractive index (RI). Detailed simulations studies were carried out to establish the resonance spectrum and sensitivity in relationship with the nanohole array pitch, diameter and gold thickness for hexagonal lattice arrangement. The plasmonic sensors were fabricated by top down approach utilizing mask-based deep ultraviolet (DUV) lithography. The plasmonic nanohole sensor was tested with a direct coupling method of incident light which allows robust and sensitive sensing platform with minimal alignment requirements. The measured bulk refractive index sensitivity is 409.4 nm/RIU and the surface mass sensitivity is 1.802 nm/ng mm-2. The sensor structures have shown promising designs and performance for achieving compact and low-cost sensor for biosensing applications.
{"title":"Plasmonic nanohole array for biosensor applications","authors":"J. Kee, S. Lim, A. P. Perera, M. K. Park, Yong Zhang","doi":"10.1109/PGC.2012.6458037","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458037","url":null,"abstract":"We explore the optical biosensing platform in plasmonic nanoholes array. The periodic nanohole structure of the biosensor and the gold coating of the sensor surface produce extraordinary light transmission (EOT) resonances of which the resonance peak shifts proportionately to the change of environment refractive index (RI). Detailed simulations studies were carried out to establish the resonance spectrum and sensitivity in relationship with the nanohole array pitch, diameter and gold thickness for hexagonal lattice arrangement. The plasmonic sensors were fabricated by top down approach utilizing mask-based deep ultraviolet (DUV) lithography. The plasmonic nanohole sensor was tested with a direct coupling method of incident light which allows robust and sensitive sensing platform with minimal alignment requirements. The measured bulk refractive index sensitivity is 409.4 nm/RIU and the surface mass sensitivity is 1.802 nm/ng mm-2. The sensor structures have shown promising designs and performance for achieving compact and low-cost sensor for biosensing applications.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125338372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458067
Zhenyang Ding, Tiegen Liu, Kun Liu, Yang Du, Dingjie Li
To improve the reliability that are very important for large-scale and long range all optical fiber sensor networks, monitoring optical fiber sensor networks is necessary. We proposed a novel method for monitoring optical fiber sensor networks using optical frequency-domain reflectometry (OFDR) which provides a narrow spatial resolution that enables us to locate closely separated reflection and discrete sensors such as fiber sensing grating and other microstructure fiber sensors. Moreover, thanks to the inherently coherent detection, a high dynamic range can be realized that allows the measurement of Rayleigh backscattering throughout a fiber network. Namely, OFDR also can monitor distributed fiber sensors By using narrow linewidth laser, OFDR's monitoring range satisfies the requirements for long range optical fiber sensor networks. In our OFDR system proposed, we can achieve to monitor optical fiber sensor networks with measurement range of a few tens of kilometers in a sub-cm spatial resolution.
{"title":"Monitoring optical fiber sensor networks by optical frequency-domain reflectometry","authors":"Zhenyang Ding, Tiegen Liu, Kun Liu, Yang Du, Dingjie Li","doi":"10.1109/PGC.2012.6458067","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458067","url":null,"abstract":"To improve the reliability that are very important for large-scale and long range all optical fiber sensor networks, monitoring optical fiber sensor networks is necessary. We proposed a novel method for monitoring optical fiber sensor networks using optical frequency-domain reflectometry (OFDR) which provides a narrow spatial resolution that enables us to locate closely separated reflection and discrete sensors such as fiber sensing grating and other microstructure fiber sensors. Moreover, thanks to the inherently coherent detection, a high dynamic range can be realized that allows the measurement of Rayleigh backscattering throughout a fiber network. Namely, OFDR also can monitor distributed fiber sensors By using narrow linewidth laser, OFDR's monitoring range satisfies the requirements for long range optical fiber sensor networks. In our OFDR system proposed, we can achieve to monitor optical fiber sensor networks with measurement range of a few tens of kilometers in a sub-cm spatial resolution.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121716735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6457939
P. Pukhrambam, Ming-Hsueh Chuang, San-Liang Lee, G. Keiser, Y. Hung, J. W. Simatupang
We investigated experimentally the effects of optical injection locking on the performance of a directly modulated semiconductor distributed feedback laser, aiming for radio-over-fiber (RoF) applications. The resonance frequency and noise level are measured at various frequency detuning and external injection ratios. Under optical injection locking with a -2.9dB injection ratio and -12.5GHz detuning, the resonance frequency improved 2.81 times and noise level at the peak reduced by 3.5dB compared to a free running laser. We also achieved 5dB dynamic range enhancement with the same injection conditions. A resonance frequency improvement of 4.2 times was achieved with increased detuning. Performances of a ROF system were evaluated at RF frequencies of 2, 2.5 and 3GHz using a 64-QAM signal. From the error vector magnitude measurements, the optical injection locking can both enhance the linearity and reduce the noise for direct modulation, and thus extending the dynamic range of input RF signals.
{"title":"Performance enhancement of radio-over-fiber system by optical injection locking of a directly modulated semiconductor laser","authors":"P. Pukhrambam, Ming-Hsueh Chuang, San-Liang Lee, G. Keiser, Y. Hung, J. W. Simatupang","doi":"10.1109/PGC.2012.6457939","DOIUrl":"https://doi.org/10.1109/PGC.2012.6457939","url":null,"abstract":"We investigated experimentally the effects of optical injection locking on the performance of a directly modulated semiconductor distributed feedback laser, aiming for radio-over-fiber (RoF) applications. The resonance frequency and noise level are measured at various frequency detuning and external injection ratios. Under optical injection locking with a -2.9dB injection ratio and -12.5GHz detuning, the resonance frequency improved 2.81 times and noise level at the peak reduced by 3.5dB compared to a free running laser. We also achieved 5dB dynamic range enhancement with the same injection conditions. A resonance frequency improvement of 4.2 times was achieved with increased detuning. Performances of a ROF system were evaluated at RF frequencies of 2, 2.5 and 3GHz using a 64-QAM signal. From the error vector magnitude measurements, the optical injection locking can both enhance the linearity and reduce the noise for direct modulation, and thus extending the dynamic range of input RF signals.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127896773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458007
F. Vollmer
Whispering gallery mode (WGM) biosensors derive their unprecedented sensitivity for label-free detection of biomolecules from the high-quality (Q) factor of an optical resonance phenomenon. Plasmonic excitations in metal nanostructures which are able to localize the WGM field at the target binding site can further enhance sensitivity by local electric field amplification. Random nanoparticle layers and nanopost antennas are investigated for this purpose, and an efficiency parameter is introduced to quantitate the local field overlap with analyte molecules, a pre-requisite for single molecule detection.
{"title":"Plasmon-enhanced whispering gallery mode biosensing","authors":"F. Vollmer","doi":"10.1109/PGC.2012.6458007","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458007","url":null,"abstract":"Whispering gallery mode (WGM) biosensors derive their unprecedented sensitivity for label-free detection of biomolecules from the high-quality (Q) factor of an optical resonance phenomenon. Plasmonic excitations in metal nanostructures which are able to localize the WGM field at the target binding site can further enhance sensitivity by local electric field amplification. Random nanoparticle layers and nanopost antennas are investigated for this purpose, and an efficiency parameter is introduced to quantitate the local field overlap with analyte molecules, a pre-requisite for single molecule detection.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125343771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458113
S. Harun, H. Ahmad, A. A. Jasim, A. Sulaiman
Fabrication of various microfiber structures such as loop, knot, mach-zenhder interferometer and coil resonators have been successfully demonstrated using a flame brushing technique. A compact inline microfiber Mach-Zehnder interferometer (MMZI) is also demonstrated for high temperature sensing. The temperature sensitivity of the device was measured to be 13.4 pm/°C with an excellent linearity for temperature measurement up to 800°C. Another MMZI structure is also proposed for application in tunable Erbium-doped fiber laser (EDFL). The operating wavelength of the laser can be tuned from 1530.2 nm to 1532.7 nm by changing the path length difference inside the MMZI from 1.6 mm to 2.7 mm at room temperature.
{"title":"Microfiber structures and its sensor and laser applications","authors":"S. Harun, H. Ahmad, A. A. Jasim, A. Sulaiman","doi":"10.1109/PGC.2012.6458113","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458113","url":null,"abstract":"Fabrication of various microfiber structures such as loop, knot, mach-zenhder interferometer and coil resonators have been successfully demonstrated using a flame brushing technique. A compact inline microfiber Mach-Zehnder interferometer (MMZI) is also demonstrated for high temperature sensing. The temperature sensitivity of the device was measured to be 13.4 pm/°C with an excellent linearity for temperature measurement up to 800°C. Another MMZI structure is also proposed for application in tunable Erbium-doped fiber laser (EDFL). The operating wavelength of the laser can be tuned from 1530.2 nm to 1532.7 nm by changing the path length difference inside the MMZI from 1.6 mm to 2.7 mm at room temperature.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128095627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6457995
Q. Meng, Xinyong Dong, Zhemin Chen, K. Ni
A fiber sensor scheme for simultaneous measurement of curvature and temperature is presented. The sensor head is formed by combining a fiber Bragg grating (FBG) with a all-fiber Mach-Zehnder interferometer (MZI), which is formed by cascading two waist-enlarged fiber tapers. The MZI is sensitive to curvature and surrounding temperature, while the FBG is only sensitive to the later. As a result, simultaneous measurement of curvature and temperature can be achieved by monitoring wavelength shifts of the MZI and the FBG. Sensitivities of 6.75 nm/m-1 and 54.7 pm/°C are achieved experimentally for curvature and temperature measurements, respectively. This sensor has a compact configuration, because the FBG is inset into the MZI. Furthermore, the sensor also has the advantages of low-cost fabrication process and good physical strength.
{"title":"Simultaneous measurement of curvature and temperature based on two waist-enlarged fiber tapers and a fiber Bragg grating","authors":"Q. Meng, Xinyong Dong, Zhemin Chen, K. Ni","doi":"10.1109/PGC.2012.6457995","DOIUrl":"https://doi.org/10.1109/PGC.2012.6457995","url":null,"abstract":"A fiber sensor scheme for simultaneous measurement of curvature and temperature is presented. The sensor head is formed by combining a fiber Bragg grating (FBG) with a all-fiber Mach-Zehnder interferometer (MZI), which is formed by cascading two waist-enlarged fiber tapers. The MZI is sensitive to curvature and surrounding temperature, while the FBG is only sensitive to the later. As a result, simultaneous measurement of curvature and temperature can be achieved by monitoring wavelength shifts of the MZI and the FBG. Sensitivities of 6.75 nm/m-1 and 54.7 pm/°C are achieved experimentally for curvature and temperature measurements, respectively. This sensor has a compact configuration, because the FBG is inset into the MZI. Furthermore, the sensor also has the advantages of low-cost fabrication process and good physical strength.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125791037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458029
Kyung Woo Kim, Junfeng Song, Qing Liu, J. Kee, Y. Shin, Mi Kyung Park
We propose an efficient multiplexed sensing system for detecting bladder cancer biomarkers without invasiveness, labeling, and high cost using a silicon-based dual microring resonator biosensor. The dual microring biosensor consists of a sensing microring and an electrical tracing microring. The working principle of the sensor is that a resonance wavelength shift of sensing ring is induced by the refractive index change resulted from biomarker binding to the ligand on the sensing microring. Then, the shift is traced and determined by the tracing ring through direct voltage supply. Also, we have shown the specific detection of HER-2 protein which is known as one of bladder cancer biomarker using the dual microring sensor.
{"title":"Development of multiplexed silicon dual microring sensor for the detection of bladder cancer markers","authors":"Kyung Woo Kim, Junfeng Song, Qing Liu, J. Kee, Y. Shin, Mi Kyung Park","doi":"10.1109/PGC.2012.6458029","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458029","url":null,"abstract":"We propose an efficient multiplexed sensing system for detecting bladder cancer biomarkers without invasiveness, labeling, and high cost using a silicon-based dual microring resonator biosensor. The dual microring biosensor consists of a sensing microring and an electrical tracing microring. The working principle of the sensor is that a resonance wavelength shift of sensing ring is induced by the refractive index change resulted from biomarker binding to the ligand on the sensing microring. Then, the shift is traced and determined by the tracing ring through direct voltage supply. Also, we have shown the specific detection of HER-2 protein which is known as one of bladder cancer biomarker using the dual microring sensor.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121900924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1109/PGC.2012.6458116
Xiaowei Zhou, Lingyi Chen, C. Tse, Trevor B. Penney, Nanguang Chen
The optical path of near-infrared light propagation in multi-layer brain models was investigated by theoretical and computational analysis for three DOT systems. The brain models are comprised a three-layer slab or three-layer semi-sphere intersected by a same size three-layer slab. In each model, the light penetration depths and the shapes of light paths for different source and detector pairs were analyzed with a numerical diffusion forward model based on the finite element method. The simulation results revealed that the light path was affected by source and detector distance, and varied in the different brain models. Specifically, the effective penetration depths were different for the different DOT systems and deeper penetration depth was observed using a fast time-domain DOT system.
{"title":"Theoretical investigation of near-infrared light path in multi-layer brain models for three DOT systems","authors":"Xiaowei Zhou, Lingyi Chen, C. Tse, Trevor B. Penney, Nanguang Chen","doi":"10.1109/PGC.2012.6458116","DOIUrl":"https://doi.org/10.1109/PGC.2012.6458116","url":null,"abstract":"The optical path of near-infrared light propagation in multi-layer brain models was investigated by theoretical and computational analysis for three DOT systems. The brain models are comprised a three-layer slab or three-layer semi-sphere intersected by a same size three-layer slab. In each model, the light penetration depths and the shapes of light paths for different source and detector pairs were analyzed with a numerical diffusion forward model based on the finite element method. The simulation results revealed that the light path was affected by source and detector distance, and varied in the different brain models. Specifically, the effective penetration depths were different for the different DOT systems and deeper penetration depth was observed using a fast time-domain DOT system.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122388584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：