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New initiation of opioids, benzodiazepines and antipsychotics following hospitalization for COVID-19 因 COVID-19 住院后新开始使用阿片类药物、苯二氮卓类药物和抗精神病药物。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-14 DOI: 10.1002/jhm.13408
Samantha Harrison MS, Krystal Capers MPH, Guanqing Chen PhD, Ji T. Liu PharmD, Ameeka Pannu MD, Valerie Goodspeed MPH, Akiva Leibowitz MD, Somnath Bose MD, MPH, FASA

Background

Patients newly initiated on opioids (OP), benzodiazepines (BZD), and antipsychotics (AP) during hospitalization are often prescribed these on discharge. Implications of this practice on outcomes remains unexplored.

Objective

To explore the prevalence and risk factors of new initiation of select OP, BZD and AP among patients requiring in-patient stays. Test the hypothesis that new prescriptions are associated with higher odds of readmission or death within 28 days of discharge.

Design

Single center retrospective cohort study.

Setting and Participants

Patients admitted to a tertiary-level medical center with either a primary diagnosis of RT-PCR positive for COVID-19 or high index of clinical suspicion thereof.

Intervention

None.

Main Outcome and Measures

Exposure was the new initiation of select common OP, BZD, and AP which were continued on hospital discharge. Outcome was a composite of 28-day readmission or death following index admission. Multivariable logistic regression was used to assess patient mortality or readmission within 28 days of discharge associated with new prescriptions at discharge.

Results

1319 patients were included in the analysis. 11.3% (149/1319) were discharged with a new prescription of select OP, BZD, or AP either alone or in combination. OP (110/149) were most prescribed followed by BZD (41/149) and AP (22/149). After adjusting for unbalanced confounders, new prescriptions (adjusted odds ratio: 2.44, 95% confidence interval: 1.42–4.12; p = .001) were associated with readmission or death within 28 days of discharge. One in nine patients admitted with a diagnosis of COVID-19 or high clinical suspicion thereof were discharged with a new prescription of either OP, BZD or AP. New prescriptions were associated with higher odds of 28-day readmission or death. Strengthening medication reconciliation processes focused on these classes may reduce avoidable harm.

背景:住院期间新开始使用阿片类药物(OP)、苯二氮卓类药物(BZD)和抗精神病药物(AP)的患者出院时通常会被处方这些药物。这种做法对治疗效果的影响仍有待探讨:目的:探讨需要住院治疗的患者中新开始使用某些 OP、BZD 和 AP 的流行率和风险因素。验证新处方与出院后 28 天内再次入院或死亡几率较高相关的假设:单中心回顾性队列研究:在三级医疗中心住院的患者,主要诊断为 COVID-19 RT-PCR 阳性或临床高度怀疑:干预措施:无:主要结果和测量指标:暴露是指出院后继续使用的新启动的精选普通 OP、BZD 和 AP。结果为指标入院后 28 天再入院或死亡的综合结果。采用多变量逻辑回归评估与出院时新处方相关的患者死亡率或出院后 28 天内的再入院情况:结果:1319 名患者被纳入分析。11.3%的患者(149/1319)在出院时新处方中选择了 OP、BZD 或 AP,无论是单独处方还是联合处方。处方最多的是 OP(110/149),其次是 BZD(41/149)和 AP(22/149)。调整不平衡混杂因素后,新处方(调整后的几率比:2.44,95% 置信区间:1.42-4.12;p = .001)与出院后 28 天内再次入院或死亡有关。每九名确诊为 COVID-19 或临床高度怀疑 COVID-19 的患者中就有一人在出院时获得了 OP、BZD 或 AP 的新处方。新处方与 28 天内再次入院或死亡的几率较高有关。加强以这些类别为重点的用药调节流程可减少可避免的伤害。
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引用次数: 0
What do patients and families observe about pediatric safety?: A thematic analysis of real-time narratives 患者和家属如何看待儿科安全?对实时叙述的专题分析。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-13 DOI: 10.1002/jhm.13388
Christine Studenmund MD, Audrey Lyndon PhD, RNC, James R. Stotts PhD, RN, Caroline Peralta-Neel MPS, Anjana E. Sharma MD, MAS, Naomi S. Bardach MD, MAS

Objectives

Data on inpatient safety are documented by hospital staff through incident reporting (IR) systems. Safety observations from families or patients are rarely captured. The Family Input for Quality and Safety (FIQS) study created a mobile health tool for pediatric patients and their families to anonymously report safety observations in real time during hospitalization. The study objectives were to describe these observations and identify domains salient to safety.

Methods

In this observational study, we analyzed pediatric patient safety reports from June 2017 to April 2018. Participants were: English-speaking family members and hospitalized patients ≥13 years old. The analysis had two stages: (1) assessment of whether narratives met established safety event criteria and whether there were companion IRs; (2) thematic analysis to identify domains.

Results

Of 248 enrolled participants, 58 submitted 120 narrative reports. Of the narratives, 68 (57%) met safety event criteria, while only 1 (0.8%) corresponded to a staff-reported IR. Twenty-five percent of narratives shared positive feedback about patient safety efforts; 75% shared constructive feedback. We identified domains particularly salient to safety: (1) patients and families as safety actors; (2) emotional safety; (3) system-centered care; and (4) shared safety domains, including medication, communication, and environment of care. Some domains capture data that is otherwise difficult to obtain (#1–3), while others fit within standard healthcare safety domains (#4).

Conclusions

Patients and families observe and report salient safety events that can fill gaps in IR data. Healthcare leaders should consider incorporating patient and family observations—collected with an option for anonymity and eliciting both positive and constructive comments.

目标:医院员工通过事故报告(IR)系统记录住院病人的安全数据。来自家属或患者的安全意见却很少被记录下来。质量与安全家庭输入(FIQS)研究为儿科患者及其家属创建了一个移动健康工具,用于在住院期间匿名实时报告安全观察结果。研究目标是描述这些观察结果,并确定与安全有关的突出领域:在这项观察性研究中,我们分析了 2017 年 6 月至 2018 年 4 月的儿科患者安全报告。参与者包括讲英语的家庭成员和年龄≥13 岁的住院患者。分析分为两个阶段:1)评估叙述是否符合既定的安全事件标准,是否有配套的IR;2)进行主题分析以确定领域:在 248 名注册参与者中,58 人提交了 120 份叙述报告。在这些叙述中,68 份(57%)符合安全事件标准,只有一份(0.8%)与工作人员报告的 IR 相符。25% 的叙述报告分享了有关患者安全工作的积极反馈;75% 分享了建设性反馈。我们确定了对安全尤为重要的领域:1)作为安全参与者的患者和家属;2)情感安全;3)以系统为中心的护理;4)共享安全领域,包括用药、沟通和护理环境。有些领域捕捉到了难以获得的数据(#1-3),而其他领域则符合标准的医疗安全领域(#4):患者和家属观察并报告突出的安全事件,可以填补 IR 数据的空白。医疗保健领导者应考虑纳入患者和家属的观察结果--收集时可选择匿名,并同时征求积极和建设性的意见。
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引用次数: 0
Outcomes associated with initial narrow-spectrum versus broad-spectrum antibiotics in children hospitalized with urinary tract infections 泌尿道感染住院患儿初始使用窄谱抗生素与广谱抗生素的相关结果。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-12 DOI: 10.1002/jhm.13390
Jessica L. Markham MD, MSc, Alaina Burns PharmD, BCPPS, Matthew Hall PhD, Matthew J. Molloy MD, MPH, John R. Stephens MD, Elisha McCoy MD, Irma T. Ugalde MD, MBE, Michael J. Steiner MD, MPH, Jillian M. Cotter MD, MSCS, Samantha A. House DO, MPH, Megan E. Collins MD, Andrew G. Yu MD, Michael J. Tchou MD, MSc, Samir S. Shah MD, MSCE

Objective

The aim of this study is to describe the proportion of children hospitalized with urinary tract infections (UTIs) who receive initial narrow- versus broad-spectrum antibiotics across children's hospitals and explore whether the use of initial narrow-spectrum antibiotics is associated with different outcomes.

Design, Setting and Participants

We performed a retrospective cohort analysis of children aged 2 months to 17 years hospitalized with UTI (inclusive of pyelonephritis) using the Pediatric Health Information System (PHIS) database.

Main Outcome and Measures

We analyzed the proportions of children initially receiving narrow- versus broad-spectrum antibiotics; additionally, we compiled antibiogram data for common uropathogenic organisms from participating hospitals to compare with the observed antibiotic susceptibility patterns. We examined the association of antibiotic type with adjusted outcomes including length of stay (LOS), costs, and 7- and 30-day emergency department (ED) revisits and hospital readmissions.

Results

We identified 10,740 hospitalizations for UTI across 39 hospitals. Approximately 5% of encounters demonstrated initial narrow-spectrum antibiotics, with hospital-level narrow-spectrum use ranging from <1% to 25%. Approximately 80% of hospital antibiograms demonstrated >80% Escherichia coli susceptibility to cefazolin. In adjusted models, those who received initial narrow-spectrum antibiotics had shorter LOS (narrow-spectrum: 33.1 [95% confidence interval; CI]: 30.8–35.4] h vs. broad-spectrum: 46.1 [95% CI: 44.1–48.2] h) and reduced costs (narrow-spectrum: $4570 [$3751–5568] versus broad-spectrum: $5699 [$5005–$6491]). There were no differences in ED revisits or hospital readmissions. In summary, children's hospitals have low rates of narrow-spectrum antibiotic use for UTIs despite many reporting high rates of cefazolin-susceptible E. coli. These findings, coupled with the observed decreased LOS and costs among those receiving narrow-spectrum antibiotics, highlight potential antibiotic stewardship opportunities.

研究目的本研究旨在描述各儿童医院中因尿路感染(UTI)住院的儿童最初使用窄谱抗生素与广谱抗生素的比例,并探讨最初使用窄谱抗生素是否与不同的治疗结果有关:我们利用儿科健康信息系统(PHIS)数据库对因UTI(包括肾盂肾炎)住院的2个月至17岁儿童进行了回顾性队列分析:我们分析了最初接受窄谱抗生素和广谱抗生素治疗的儿童比例;此外,我们还汇编了参与医院常见尿路病原菌的抗生素图谱数据,以便与观察到的抗生素敏感性模式进行比较。我们研究了抗生素类型与调整后结果的关系,包括住院时间(LOS)、费用、7 天和 30 天急诊科(ED)复诊率和再入院率:我们在 39 家医院中发现了 10,740 例UTI 住院病例。约有 5% 的患者首次使用了窄谱抗生素,医院层面的窄谱抗生素使用率从大肠埃希菌敏感率 80% 到头孢唑啉不等。在调整后的模型中,首次使用窄谱抗生素的患者的住院时间更短(窄谱:33.1(95% 置信区间[CI]:30.8-35.4)小时,广谱:46.1(95% 置信区间:44.1-48.2)小时),费用更低[窄谱:4570 美元(3751-5568 美元),广谱:5699 美元(5005-6491 美元)]。急诊室复诊率和再住院率没有差异。总之,尽管许多儿童医院报告的头孢唑啉敏感大肠杆菌感染率较高,但窄谱抗生素在UTI中的使用率较低。这些发现以及观察到的接受窄谱抗生素治疗的患者的住院时间和费用的减少,凸显了潜在的抗生素监管机会。
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引用次数: 0
Maintaining public trust in organ donation while expanding the organ pool 在扩大器官库的同时,保持公众对器官捐赠的信任。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-12 DOI: 10.1002/jhm.13409
Brendan Parent JD
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引用次数: 0
The promise and peril of generative artificial intelligence for daily hospitalist practice 生成式人工智能对住院医生日常工作的承诺与危险。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-09 DOI: 10.1002/jhm.13363
Adam Rodman MD, MPH, Zahir Kanjee MD, MPH

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引用次数: 0
Sex concordance between physicians and patients and discharge opioid prescribing 医生与患者之间的性别一致性以及阿片类药物的出院处方。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-09 DOI: 10.1002/jhm.13389
Aksharananda Rambachan MD, MPH, Mihir Joshi MD, Andrew D. Auerbach MD, Margaret C. Fang MD, MPH

Inpatient pain management is challenging for clinicians and inequities are prevalent. We examined sex concordance between physicians and patients to determine if discordance was associated with disparate opioid prescribing on hospital discharge. We examined 15,339 hospitalizations from 2013 to 2021. Adjusting for patient, clinical, and hospitalization-level characteristics, we calculated the odds of a patient receiving an opioid on discharge and the days of opioids prescribed across all hospitalizations and for patients admitted with a common pain diagnosis. We did not find an overall association between physician–patient sex concordance and discharge opioid prescriptions. Compared to concordant sex pairs, patients in discordant pairs were not significantly less likely to receive an opioid prescription (odds ratio: 1.04; 95% confidence interval [CI]: 0.95, 1.15) and did not receive significantly fewer days of opioids (2.1 fewer days of opioids; 95% CI: −4.4, 0.4). Better understanding relationships between physician and patient characteristics is essential to achieve more equitable prescribing.

住院病人的疼痛管理对临床医生来说极具挑战性,而且不公平现象普遍存在。我们研究了医生和患者之间的性别一致性,以确定不一致是否与出院时阿片类药物处方的差异有关。我们研究了 2013 年至 2021 年期间的 15,339 例住院病例。在对患者、临床和住院水平特征进行调整后,我们计算了患者出院时接受阿片类药物治疗的几率,以及所有住院患者和以常见疼痛诊断入院的患者的阿片类药物处方天数。我们没有发现医患性别一致与出院阿片类药物处方之间存在整体关联。与性别一致的医患配对相比,性别不一致的医患配对中患者获得阿片类药物处方的可能性并没有显著降低(几率比:1.04;95% 置信区间 [CI]:0.95, 1.15),获得阿片类药物的天数也没有显著减少(阿片类药物天数减少 2.1 天;95% CI:-4.4, 0.4)。更好地了解医生和患者特征之间的关系对于实现更公平的处方至关重要。
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引用次数: 0
Handle with care: Preventing harm during critical care unit relocation 小心处理:防止重症监护室搬迁过程中的伤害。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-07 DOI: 10.1002/jhm.13361
Maitreya Coffey MD, FAAP, FRCP(C), Monica E. Kleinman MD, FAAP
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引用次数: 0
Development of antibiotic metrics for hospitalists via multi-institutional modified Delphi survey 通过多机构改良德尔菲调查为住院医生制定抗生素指标
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-02 DOI: 10.1002/jhm.13377
Allison Bond MD, Sandra Oreper MPH, Priya Prasad PhD, Emily Abdoler MD, Sarah Doernberg MD, MAS

Background

Closing the gap between evidence-supported antibiotic use and real-world prescribing among clinicians is vital for curbing excessive antibiotic use, which fosters antimicrobial resistance and exposes patients to antimicrobial side effects. Providing prescribing information via scorecard improves clinician adherence to quality metrics.

Objective

We aimed to delineate actionable, relevant antimicrobial prescribing metrics extractable from the electronic health record in an automated way.

Design

We used a modified Delphi consensus-building approach.

Settings and Participants

Our study entailed two iterations of an electronic survey disseminated to hospital medicine physicians at 10 academic medical centers nationwide.

Main Outcomes and Measures

Main outcomes comprised consensus metrics describing the quality of antibiotic prescribing to hospital medicine physicians.

Results

Twenty-eight participants from 10 United States institutions completed the first survey version containing 38 measures. Sixteen respondents completed the second survey, which contained 37 metrics. Sixteen metrics, which were modified based on qualitative survey feedback, met criteria for inclusion in the final scorecard. Metrics considered most relevant by hospitalists focused on the appropriate de-escalation of antimicrobial therapy, selection of guideline-concordant antibiotics, and appropriate duration of treatment for common infectious syndromes. Next steps involve prioritization and implementation of these metrics based on quality gaps at our institution, focus groups exploring impressions of clinicians who receive a scorecard, and analysis of antibiotic prescribing patterns before and after metric implementation. Other institutions may be able to implement metrics from this scorecard based on their own quality gaps to provide hospitalists with automated feedback related to antibiotic prescribing.

背景缩小有证据支持的抗生素使用与临床医生实际处方之间的差距对于遏制过度使用抗生素至关重要,因为过度使用抗生素会助长抗菌药耐药性并使患者面临抗菌药副作用。通过记分卡提供处方信息可提高临床医生对质量指标的遵守程度。目标我们旨在以自动化方式从电子健康记录中提取可操作的相关抗菌药物处方指标。设置和参与者我们的研究需要对一项电子调查进行两次迭代,调查对象是全国 10 家学术医疗中心的医院内科医生。主要结果和衡量标准主要结果包括描述医院内科医生抗生素处方质量的共识指标。结果来自美国 10 家机构的 28 名参与者完成了包含 38 项衡量标准的第一版调查。16 名受访者完成了包含 37 项指标的第二版调查。根据定性调查反馈意见修改后的 16 项指标符合纳入最终记分卡的标准。住院医生认为最相关的指标主要集中在抗菌治疗的适当降级、选择与指南一致的抗生素以及常见感染综合征的适当治疗时间。下一步工作包括根据本机构的质量差距确定这些指标的优先级并加以实施,通过焦点小组探讨临床医生收到记分卡后的印象,以及分析指标实施前后的抗生素处方模式。其他医疗机构也可以根据自身的质量差距实施该记分卡中的指标,为住院医生提供与抗生素处方相关的自动反馈。
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引用次数: 0
Implementation of a same-day, round-trip interventional endoscopy service for rural and critical access hospital patients 为农村和危急重症医院患者提供当天往返的介入内镜检查服务
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-02 DOI: 10.1002/jhm.13333
Mithun R. Suresh MD, Najib Nassani MD, MSc, Luis A. Servin-Abad MD, Deanne B. Walz MSN, BSN, CGRN, Paul R. Davis MD, Christopher W. Boelter MD, MBA, Tyler G. Goettl MD, Greg J. Beilman MD, Martin L. Freeman MD, Andrew P. J. Olson MD, Fateh Bazerbachi MD
<p>Access to interventional endoscopy expertise is often restricted to tertiary care centers and may not be available in rural or critical access hospitals. In central Minnesota, St. Cloud Hospital is the tertiary referral center for the state's central region, with 489 licensed beds and a level II trauma center, comprehensive stroke center, intensive care unit (ICU), and staffed with physicians from nearly all medical and surgical subspecialties. During the COVID-19 pandemic, patients presenting to rural or critical access hospitals in central Minnesota and needing urgent endoscopic procedures had difficulty accessing timely care due to the lack of beds at our institution or other capable facilities in Minnesota,<span><sup>1</sup></span> a problem which persists to the present day. Critical access hospitals generally have fewer than 25 inpatient beds, are located in rural areas over 35 miles from another hospital, and have limited on-site subspecialty support.<span><sup>2</sup></span> Accordingly, our operational objective was to develop a round-trip, same-day endoscopic procedures service where patients would transfer by ambulance to our institution to undergo the necessary procedures and then return to the referring hospital for further care. The purpose of this manuscript is to describe our experience and outcomes with this service, given the dearth of published reports on this care model.<span><sup>3-5</sup></span></p><p>This service aims to provide interventional endoscopy care for rural and critical access hospital patients that are appropriate candidates in 1–2 days from receiving a request from a referring provider, avoid admission to our institution following the procedures, and recover post-procedurally in the referring hospital and not need to transfer back to our institution during the index hospitalization (with index hospitalization being the hospitalization during which the round-trip occurs). These were the desired outcomes over the first 20 months of the operation of this service, and we concurrently sought to ensure the safety and feasibility of this service to improve access to endoscopic care for patients in rural and critical access hospitals.</p><p>We received approval to gather and publish data using our electronic medical record (EMR) Epic (including Care Everywhere and paper records) from the CentraCare Institutional Review Board. The general workflow algorithm for round-trip procedures is shown in Figure 1,   with some additional information as follows. During daytime hours, referring providers caring for patients needing endoscopic procedures would contact our institution's transfer center and be connected with the medical officer of the day (MOD), a role filled daily by a hospitalist who is the accepting physician for all patients directly admitted to the hospital medicine service; all patients needing endoscopic procedures are admitted by the hospital medicine service with gastroenterology consultation at our institu
过程指标(随后是结果)是(1)为患者安排回程救护车运送的能力(82/84,97.6%);(2)在完成往返手术后直接出院回家的患者人数(2/84,2.4%);(3)在完成往返手术后意外需要进行转诊医院无法提供的其他手术或干预,从而需要入住本院的患者人数(2/84,2.4%);这些手术分别是(a)胆道插管重复尝试和(b)胆囊切除术。结果指标(其次是结果)为(1)在提出申请后 1-2 天内完成巡回手术的候选患者人数(84/84,100%);(2)在完成巡回手术后立即入住本院的患者人数(4/84,4.8%);(3)在指标住院期间完成巡回手术后需要转回本院的患者人数(0/84,0.0%)。除表 1 所示结果外,没有患者在指标住院期间死亡,在胆石症患者中,有 30 人在指标住院期间在转诊医院进行了胆囊切除术。有关集中进行某些内镜手术的重要性的数据非常可靠6,因此,让经验丰富的高级内镜医师为农村患者提供这些手术,并为他们提供三级护理,同时还能利用当地的外科专业知识,是我们的医疗机构和患者所看重的。患者可以在离家较近的地方康复,住院医生可以继续为其他患者提供三级住院服务。与麻醉科团队就即将到来的巡回检查进行早期沟通有助于提高工作流程的效率,并确保在转院前完成术前检查(如血液检查、心电图);有时还需要填写一份术前评估表,将这些信息提供给本机构的麻醉科和胃肠科团队。对于远道而来的病人,内窥镜检查人员会尽可能提供病人准备返回的预计时间,以帮助确保有人员可以返回运送病人。这种与救护人员的沟通有助于避免因无法确保返程交通而被送入本院,并使病人在返回转诊医院时减少延误。最后,从高级医疗服务提供者到护士再到科室护理协调员,内窥镜检查人员的支持对这项服务的运作至关重要。由于他们与转诊医疗团队的频繁接触,在帮助执行往返工作流程的几乎每一步并提高其效率方面,他们都是非常宝贵的队友。在 84 名患者中,79 名患者的付款总额为 474,494.44 美元,其中 5 名患者尚未收到全额付款。这些付款为专业人员费用和医院费用。在交通费方面,由本医疗系统的救护车机构运送的 25 名患者中,22 名患者的总费用为 51,802.79 美元,其中 3 名患者的全额费用尚未收到。在这 25 名患者中,有 24 名患者的到达和返回交通费用由保险机构支付,1 名患者的费用由自己支付。至于其余 59 名患者,由于由外部救护车机构帮助转运,因此无法提供全部转运费用详情。胆总管结石和胆管炎是我们最常见的两种往返适应症,其住院费用因 ERCP 的时间不同而有很大差异(50,766-90,566 美元)。8 因此,考虑到我们的护理模式是在 1-2 天内快速促成往返患者,以及往返患者的总住院时间,我们有很大的节省住院费用的潜力。作者声明无利益冲突。本研究已获得 CentraCare 机构审查委员会批准。
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引用次数: 0
Don't hold the metformin: Enhancing inpatient diabetes education to encourage best practices in a public hospital 别憋着二甲双胍:加强住院病人糖尿病教育,鼓励公立医院采用最佳做法
IF 2.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-05-02 DOI: 10.1002/jhm.13269
Samantha F. Sanders MD, MBA, Michael S. Shen MD, Daniel Alaiev BBA, Brianna Knoll MD, MBA, Hyung J. Cho MD, Surafel Tsega MD, Mona Krouss MD, Ian Fagan MD, Amanda Klinger MD
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引用次数: 0
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Journal of hospital medicine
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