Pub Date : 2026-03-01Epub Date: 2025-11-21DOI: 10.1016/j.healun.2025.11.018
Joseph B. Lerman MD, Stuart D. Russell
{"title":"Pressure points: Hemodynamics and waitlist risk before heart transplant","authors":"Joseph B. Lerman MD, Stuart D. Russell","doi":"10.1016/j.healun.2025.11.018","DOIUrl":"10.1016/j.healun.2025.11.018","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 363-364"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-04DOI: 10.1016/j.healun.2025.11.025
Alexander R. Berg BS, Aravind Krishnan MD, Elbert E. Heng MD, Ashley Y. Choi MD, MHS, Alyssa C. Garrison MS, Daniel I. Alnasir BS, Y. Chawannuch Ruaengsri MD, Yasuhiro Shudo MD, PHD, Y. Joseph Woo MD, John W. MacArthur MD
{"title":"Invited response letter","authors":"Alexander R. Berg BS, Aravind Krishnan MD, Elbert E. Heng MD, Ashley Y. Choi MD, MHS, Alyssa C. Garrison MS, Daniel I. Alnasir BS, Y. Chawannuch Ruaengsri MD, Yasuhiro Shudo MD, PHD, Y. Joseph Woo MD, John W. MacArthur MD","doi":"10.1016/j.healun.2025.11.025","DOIUrl":"10.1016/j.healun.2025.11.025","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 528-529"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-10DOI: 10.1016/j.healun.2025.12.006
Tamas Alexy MD, PhD , Sasa Vukelic MD, PhD
{"title":"Sex-biased immune rewiring and the risk of cardiac allograft vasculopathy in heart transplant recipients: Initial steps in solving a complex puzzle","authors":"Tamas Alexy MD, PhD , Sasa Vukelic MD, PhD","doi":"10.1016/j.healun.2025.12.006","DOIUrl":"10.1016/j.healun.2025.12.006","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 375-377"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Direct oral anticoagulants (DOACs) are widely used in chronic thromboembolic pulmonary hypertension (CTEPH); however, the safety and efficacy of reduced-dose regimens remain unclear. We retrospectively analyzed 721 follow-up selective pulmonary angiograms from 239 patients who completed balloon pulmonary angioplasty and received long-term anticoagulation with low-dose DOACs, standard-dose DOACs, or vitamin K antagonists (VKAs). Baseline characteristics, follow-up outcomes, and the incidence of pulmonary artery fresh floating thrombi were compared using the Kruskal-Wallis and Fisher’s exact tests.
Patients on low-dose DOACs were older, had lower body weights and more frequent renal impairment. Fresh thrombi were identified in 22 cases (3.1%), with a higher incidence in the low-dose DOAC (11.0%) group versus standard-dose (2.1%, p = 0.044) and VKAs (2.5%, p = 0.018). Hemodynamic improvements were comparable across groups. Low-dose DOACs were associated with a higher thrombus rate, suggesting potential under-anticoagulation. These findings highlight the need for CTEPH-specific anticoagulation strategies to balance thrombotic and bleeding risks.
{"title":"Pulmonary artery fresh floating thrombus in patients with chronic thromboembolic pulmonary hypertension on low-dose direct oral anticoagulants: A single-center angiographic observational study","authors":"Takeshi Suetomi MD, PhD , Hiroto Shimokawahara MD, PhD , Keiichiro Kuronuma MD, PhD , Yoichi Sugiyama MD, PhD , Ayane Miyagi MD , Yoshitake Fukuda MD , Misaki Kanezawa MD , Kazuki Suruga MD, PhD , Kazuna Hayashi MD , Soichiro Kobashi MD , Masataka Shigetoshi MD, PhD , Isao Tabuchi MD, PhD , Aiko Ogawa MD, PhD , Atsuyuki Watanabe MD, PhD , Takeshi Yamamoto MD, PhD , Hiromi Matsubara MD, PhD","doi":"10.1016/j.healun.2025.10.031","DOIUrl":"10.1016/j.healun.2025.10.031","url":null,"abstract":"<div><div>Direct oral anticoagulants (DOACs) are widely used in chronic thromboembolic pulmonary hypertension (CTEPH); however, the safety and efficacy of reduced-dose regimens remain unclear. We retrospectively analyzed 721 follow-up selective pulmonary angiograms from 239 patients who completed balloon pulmonary angioplasty and received long-term anticoagulation with low-dose DOACs, standard-dose DOACs, or vitamin K antagonists (VKAs). Baseline characteristics, follow-up outcomes, and the incidence of pulmonary artery fresh floating thrombi were compared using the Kruskal-Wallis and Fisher’s exact tests.</div><div>Patients on low-dose DOACs were older, had lower body weights and more frequent renal impairment. Fresh thrombi were identified in 22 cases (3.1%), with a higher incidence in the low-dose DOAC (11.0%) group versus standard-dose (2.1%, <em>p</em> = 0.044) and VKAs (2.5%, <em>p</em> = 0.018). Hemodynamic improvements were comparable across groups. Low-dose DOACs were associated with a higher thrombus rate, suggesting potential under-anticoagulation. These findings highlight the need for CTEPH-specific anticoagulation strategies to balance thrombotic and bleeding risks.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 452-456"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-14DOI: 10.1016/j.healun.2025.10.004
Fan Yang M.D. , Jinteng Feng M.D. , Yixing Li Ph.D. , Guangjian Zhang M.D.
{"title":"Lung protective ventilation in organ donors: Moving toward precision and contextualized strategies","authors":"Fan Yang M.D. , Jinteng Feng M.D. , Yixing Li Ph.D. , Guangjian Zhang M.D.","doi":"10.1016/j.healun.2025.10.004","DOIUrl":"10.1016/j.healun.2025.10.004","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 522-523"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-12DOI: 10.1016/j.healun.2025.10.033
Kelly M. Pennington MD , Sahar A. Saddoughi MD, PhD
{"title":"I can breathe again, and the best is yet to come—understanding quality of life after lung transplantation","authors":"Kelly M. Pennington MD , Sahar A. Saddoughi MD, PhD","doi":"10.1016/j.healun.2025.10.033","DOIUrl":"10.1016/j.healun.2025.10.033","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 440-441"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-10-20DOI: 10.1016/j.healun.2025.10.005
Mary G. Bowring MPH , Jessica M. Ruck MD, PhD , Zeba Nauroz , Omar Saeed MD , Maryjane Farr MD , Shelley Hall MD , Zubair Hashmi MD , Saima Aslam MD , Marlena Habal MD , Aaron A.R. Tobian MD, PhD , Allan B. Massie PhD , Vagish Hemmige MD , Dorry L. Segev MD, PhD , Christine M. Durand MD
Background
Under the HIV Organ Policy Equity (HOPE) Act, transplants from donors with HIV to recipients with HIV (HIV D+/R+) have been largely limited to kidney and liver. However, recent modifications to HOPE research guidelines allow broader participation of cardiothoracic programs.
Methods
To quantify potential cardiothoracic HOPE donors, we used Scientific Registry of Transplant Recipients (SRTR) data (3/2016-12/2024) to identify 101,200 donors without HIV and 273 HOPE donors (with true and false positive HIV tests). Using logistic regression, we predicted the probability of having a heart or lung(s) used for transplant among donors without HIV that had a kidney or liver used. We then applied model parameters to HOPE donors that had a kidney or liver used to estimate the number of HOPE donors that might have been cardiothoracic donors if the practice were expanded.
Results
Among donors without HIV, cardiothoracic donation was associated with age, cause of death, hepatitis C, hypertension, diabetes, smoking, cardiovascular disease, blood gas, and circulatory death. Applying our model, an estimated 41.0% (N = 111), 18.7% (N = 51), and 15.2% (N = 41) of HOPE donors were potential heart, any lung (single or double), or double-lung donors, as compared to 32.3%, 21.8%, and 18.2% of abdominal organ donors without HIV, respectively. This translated to an annual 13-18 potential heart and 5-8 potential lung transplants (of which 4-6 would be double-lung transplants) from HOPE donors.
Conclusions
If HIV D+/R+ is more widely expanded to cardiothoracic transplantation, 41% of HOPE kidney and liver donors have the potential to donate a heart and almost 20% to donate a lung to candidates with HIV.
{"title":"Potential pool of cardiothoracic organs from donors with HIV","authors":"Mary G. Bowring MPH , Jessica M. Ruck MD, PhD , Zeba Nauroz , Omar Saeed MD , Maryjane Farr MD , Shelley Hall MD , Zubair Hashmi MD , Saima Aslam MD , Marlena Habal MD , Aaron A.R. Tobian MD, PhD , Allan B. Massie PhD , Vagish Hemmige MD , Dorry L. Segev MD, PhD , Christine M. Durand MD","doi":"10.1016/j.healun.2025.10.005","DOIUrl":"10.1016/j.healun.2025.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Under the HIV Organ Policy Equity (HOPE) Act, transplants from donors with HIV to recipients with HIV (HIV D+/R+) have been largely limited to kidney and liver. However, recent modifications to HOPE research guidelines allow broader participation of cardiothoracic programs.</div></div><div><h3>Methods</h3><div>To quantify potential cardiothoracic HOPE donors, we used Scientific Registry of Transplant Recipients (SRTR) data (3/2016-12/2024) to identify 101,200 donors without HIV and 273 HOPE donors (with true and false positive HIV tests). Using logistic regression, we predicted the probability of having a heart or lung(s) used for transplant among donors without HIV that had a kidney or liver used. We then applied model parameters to HOPE donors that had a kidney or liver used to estimate the number of HOPE donors that might have been cardiothoracic donors if the practice were expanded.</div></div><div><h3>Results</h3><div>Among donors without HIV, cardiothoracic donation was associated with age, cause of death, hepatitis C, hypertension, diabetes, smoking, cardiovascular disease, blood gas, and circulatory death. Applying our model, an estimated 41.0% (<em>N</em> = 111), 18.7% (<em>N</em> = 51), and 15.2% (<em>N</em> = 41) of HOPE donors were potential heart, any lung (single or double), or double-lung donors, as compared to 32.3%, 21.8%, and 18.2% of abdominal organ donors without HIV, respectively. This translated to an annual 13-18 potential heart and 5-8 potential lung transplants (of which 4-6 would be double-lung transplants) from HOPE donors.</div></div><div><h3>Conclusions</h3><div>If HIV D+/R+ is more widely expanded to cardiothoracic transplantation, 41% of HOPE kidney and liver donors have the potential to donate a heart and almost 20% to donate a lung to candidates with HIV.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 460-467"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-08DOI: 10.1016/j.healun.2025.11.016
Aaron M. Williams MD, Swaroop Bommareddi MD, John M. Trahanas MD, Awab Ahmad MD, Ashish S. Shah MD, Brian Lima MD
{"title":"Ex-vivo heart perfusion in agonal periods greater than 30 min: Interpretation requires caution","authors":"Aaron M. Williams MD, Swaroop Bommareddi MD, John M. Trahanas MD, Awab Ahmad MD, Ashish S. Shah MD, Brian Lima MD","doi":"10.1016/j.healun.2025.11.016","DOIUrl":"10.1016/j.healun.2025.11.016","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 526-527"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-12DOI: 10.1016/j.healun.2025.11.006
Susanna Mak MD, PhD
{"title":"“Advanced hemodynamics”—moving the field forward","authors":"Susanna Mak MD, PhD","doi":"10.1016/j.healun.2025.11.006","DOIUrl":"10.1016/j.healun.2025.11.006","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 386-387"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145515886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号