Journal of geriatric oncology最新文献

{"title":"Designing observational studies to estimate treatment effects in geriatric oncology: A closer look at confounding and its mitigation","authors":"Nienke A. de Glas , Sophie Pilleron , Esther Bastiaannet , Florence Canouï-Poitrine , Adolfo González Serrano , Eva Culakova , Jennifer L. Lund","doi":"10.1016/j.jgo.2024.102159","DOIUrl":"10.1016/j.jgo.2024.102159","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 2","pages":"Article 102159"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The International Society of Geriatric Oncology (SIOG) Methods Working Group","authors":"Sophie Pilleron , Esther Bastiaannet , Carine Bellera , Florence Canouï-Poitrine , Eva Culakova , Nienke de Glas , Adolfo González Serrano , Kristen R. Haase , Jessica L. Krok-Schoen , Tomonori Mizutani , India Pinker , Jennifer Lund","doi":"10.1016/j.jgo.2025.102217","DOIUrl":"10.1016/j.jgo.2025.102217","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102217"},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between symptom burden and fall risks in older adults with a cancer history: Findings from the 2011–2015 National Health and Aging Trends Study","authors":"Myeongjin Bae , Nancy M. Gell","doi":"10.1016/j.jgo.2025.102212","DOIUrl":"10.1016/j.jgo.2025.102212","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102212"},"PeriodicalIF":3.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of enfortumab vedotin for locally advanced or metastatic urothelial carcinoma in patients aged 80 years and older: A multicenter retrospective study in Japan","authors":"Yuki Kobari , Junpei Iizuka , Hanae Kondo , Makiko Ichioka , Shun Watanabe , Kazutaka Nakamura , Toshihide Horiuchi , Shinsuke Mizoguchi , Kazuhiko Yoshida , Hiroaki Shimmura , Yasunobu Hashimoto , Tsunenori Kondo , Hiroshi Kobayashi , Toshio Takagi","doi":"10.1016/j.jgo.2025.102216","DOIUrl":"10.1016/j.jgo.2025.102216","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102216"},"PeriodicalIF":3.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Describing the outcomes of frail patients undergoing treatment with systemic therapies for acute myeloid leukaemia: A systematic review","authors":"Aaron Sia ,&nbsp;Sakshi Chopra ,&nbsp;Victoria Y. Ling ,&nbsp;James Fletcher ,&nbsp;Ruth Eleanor Hubbard ,&nbsp;Peter Mollee ,&nbsp;Emily Gordon ,&nbsp;Natasha Reid ,&nbsp;Leila Shafiee Hanjani","doi":"10.1016/j.jgo.2025.102196","DOIUrl":"10.1016/j.jgo.2025.102196","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute myeloid leukaemia (AML) is a disease of the older person. Due to the demands of intensive chemotherapy, there is a significant risk of over or undertreatment, leading to either iatrogenic harm or missed windows of opportunity for remission or cure. Better tools to aid clinical decision making and risk stratify patients are needed. We aimed to investigate the association between frailty and the treatment and disease-related outcomes of adults receiving systemic therapy for AML.</div></div><div><h3>Materials and Methods</h3><div>A systematic search of PubMed, EMBASE, CINAHL, and Web of Science databases was undertaken for studies assessing frailty (defined as multi-dimensional assessment evaluating two or more geriatric relevant domains or usage of a validated geriatric assessment screening tool) in the setting of adults undergoing systemic therapy for AML.</div></div><div><h3>Results</h3><div>We identified 6,644 publications, 16 of which met inclusion criteria for extraction. The most commonly described outcomes were overall survival (OS) (<em>n</em> = 12), mortality (<em>n</em> = 8), response rate (<em>n</em> = 6), and high grade toxicity (<em>n</em> = 5). Eleven studies correlated frailty with treatment outcomes: frailty was predictive of lower OS (n = 5), higher mortality (<em>n</em> = 3), and more high grade toxicity (<em>n</em> = 1). OS in particular retained this relationship when controlling for variables such as molecular markers and performance status. Significant heterogeneity in outcome reporting and frailty assessment precluded meta-analysis. Included studies were generally of moderate quality.</div></div><div><h3>Discussion</h3><div>Frailty was predictive of poorer outcomes in patients with AML distinct from and complimentary to traditional disease prognostic schema. Routine implementation of frailty assessment could represent an important tool to risk stratify patients and improve clinical decision making.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102196"},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of comprehensive geriatric assessment on treatment decisions, supportive care received, and postoperative outcomes in older adults with cancer undergoing surgery: A systematic review","authors":"Domenica Disalvo ,&nbsp;Maja V. Garcia ,&nbsp;Wee Kheng Soo ,&nbsp;Jane Phillips ,&nbsp;Heather Lane ,&nbsp;Elise Treleaven ,&nbsp;Timothy To ,&nbsp;Jack Power ,&nbsp;Ingrid Amgarth-Duff ,&nbsp;Meera Agar","doi":"10.1016/j.jgo.2025.102197","DOIUrl":"10.1016/j.jgo.2025.102197","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgery is an essential part of cancer treatment, particularly for localised solid tumours. Geriatric assessments (GA) with tailored interventions or comprehensive GA (CGA) can identify frailty factors and needs of older adults with cancer, assisting treatment decisions and care strategies to reduce postoperative complications. This systematic review summarises the effects of GA/CGA compared to usual care for older adults with cancer intended for surgery: their impact on treatment decisions, supportive care interventions, postoperative complications, survival, and health-related quality of life (HRQOL).</div></div><div><h3>Materials and Methods</h3><div>We conducted a systematic search of MEDLINE, EMBASE, CINAHL, and PubMed (January 2000–October 2022) for randomised controlled trials (RCTs) or cohort studies with a comparison group on the effects of GA/CGA in older adults with cancer (≥65 years) intended for surgery. This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Due to heterogeneity in study designs and reporting, a meta-analysis was not possible; results are narratively described.</div></div><div><h3>Results</h3><div>From 12,440 citations, 312 were selected for full-text review. Thirteen studies reporting on 12 trials were included for analysis: four RCTs and eight cohort studies with comparison groups (three prospective, five retrospective). RCTs ranged in sample size (122–475; mean 249), with variability in who performed GA/CGA, disciplines involved, and team integration. Primary outcomes included impact of GA/CGA on postoperative delirium (two studies), Clavien-Dindo (CD) grade II-V postoperative complications (one study), hospital length of stay (one study), and a composite criterion including mortality, functional impairment, and weight loss (one study). All RCTs scored high for risk of bias due to underpowering for their primary outcome; none met their primary endpoint. After adjustment for prespecified factors in secondary analyses, one RCT found GA/CGA significantly reduced the odds of postoperative complications (CD grade I-V) (adjusted-OR: 0.33, 95 %CI: 0.11–0.95; <em>p</em> = 0.05) due to fewer grade I-II complications. One RCT reported no significant difference between groups in HRQOL: intervention patients reported less pain at discharge, but this difference disappeared at three-month follow-up.</div></div><div><h3>Discussion</h3><div>Well-powered, high-quality trials are needed to determine the impact of GA/CGA on optimising surgical treatment decisions, supportive care and postoperative outcomes for older adults with cancer.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102197"},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer in older patients: Can CDK 4/6 inhibitors make the difference in the adjuvant setting?","authors":"Lorenzo Dottorini ,&nbsp;Italo Sarno ,&nbsp;Giandomenico Di Menna ,&nbsp;Andrea Luciani ,&nbsp;Fausto Petrelli","doi":"10.1016/j.jgo.2025.102213","DOIUrl":"10.1016/j.jgo.2025.102213","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102213"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of robotic colon surgery in older patients with colon cancer","authors":"Ellen Van Eetvelde ,&nbsp;Manu Verweirder ,&nbsp;Lore Decoster ,&nbsp;Daniel Jacobs-Tulleneers-Thevissen","doi":"10.1016/j.jgo.2025.102205","DOIUrl":"10.1016/j.jgo.2025.102205","url":null,"abstract":"<div><h3>Introduction</h3><div>Older patients are less likely to undergo curative surgery for colon cancer (CC) because of a higher rate in comorbidities that increases the risk for complications and mortality. Robot-assisted surgery could be an alternative minimally invasive approach allowing surgical treatment in a higher percentage of patients above 70 years old. This study aims at evaluating the safety of robotic surgery in older patients with CC.</div></div><div><h3>Materials and Methods</h3><div>Prospectively collected data from all patients receiving robot-assisted surgery for CC at a tertiary center between 2016 and 2022 were used for retrospective subgroup analysis based on age and tumor location (right-sided, left-sided). Perioperative outcome including 30-day major morbidity and 90-day mortality rate, overall survival (OS) and cancer-specific survival (CSS) were compared.</div></div><div><h3>Results</h3><div>In total, 231 patients met inclusion criteria of the study: <em>n</em> = 89 &lt; 70 years, <em>n</em> = 64 between 70 and 79 years, <em>n</em> = 72 between 80 and 89 years, and n = 6 ≥ 90 years. No differences in 90-day mortality or 30-day major morbidity were observed between age groups. Thirty-day overall morbidity, length of stay (LOS), and days to full mobility were increased in ≥70-year-olds for right- and left-sided surgery. One-, three-, and five-year CSS did not differ while the three- and five-year OS significantly decreased with age.</div></div><div><h3>Discussion</h3><div>Robot-assisted surgery for resection of CC can be used safely in older patients.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102205"},"PeriodicalIF":3.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between social vulnerability index and survival in older adults with gastrointestinal cancers – The CARE Registry","authors":"Mackenzie E. Fowler ,&nbsp;Srihitha Padamatinti ,&nbsp;Elizabeth Baker ,&nbsp;Gabriela Oates ,&nbsp;Ariann Nassel ,&nbsp;Noha Sharafeldin ,&nbsp;Grant R. Williams ,&nbsp;Smith Giri","doi":"10.1016/j.jgo.2025.102203","DOIUrl":"10.1016/j.jgo.2025.102203","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults represent a majority of gastrointestinal (GI) cancer cases. Social determinants of health, such as neighborhood-level social vulnerability index (SVI), are associated with frailty, a predictor of mortality. The association between social vulnerability and survival is understudied.</div></div><div><h3>Materials and Methods</h3><div>We evaluated 876 adults ≥60y with GI cancer enrolled in the Cancer &amp; Aging Resilience Evaluation (CARE) Registry prior to chemotherapy. Exposure was the Center for Disease Control and Prevention's SVI in tertiles. SVI ranks census tracts between 0th and 100th percentile for lowest and highest vulnerability, respectively. Outcome was survival (enrollment to end of follow-up). Associations between SVI and survival were estimated using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Median age of patients was 69y, 58 % were male, 22 % were non-Hispanic Black, 30 % had colorectal, 29 % had pancreatic cancer, and 70 % had stage III/IV disease. About 44 % of participants died in median 17 months follow-up. Frailty status differed by SVI tertile (tertile 1: 26.8 %; tertile 2: 34.3 %; tertile 3: 43.4 %, <em>p</em>-value: &lt;0.001). Adjusting for age, sex, and cancer type/stage, those living in neighborhoods in the highest SVI tertile had 6 % higher hazard of death (95 % confidence interval [CI]: 0.8, 1.4) and in the second-highest tertile had 8 % higher hazard of death (95 % CI: 0.9, 1.4) compared to those in the lowest tertile. This association may be driven by the SVI housing characteristics theme [tertile 2: hazard ratio (HR) 1.40 (95 % CI: 1.09, 1.79); tertile 3: HR 1.20 (95 % CI: 0.93, 1.55)].</div></div><div><h3>Discussion</h3><div>We did not find a statistically significant association between SVI and survival among older adults with GI cancers. Prior evidence of associations between SVI and overall area-level mortality may not reflect individual-level mortality specific to older adults. Prior evidence of associations between SVI and individual-level frailty among older adults with GI cancers suggests SVI may confer greater risk on development of frailty, which could indirectly impact survival. SVI of at-risk areas may need consideration when designing solutions to improve frailty among older adults with GI cancers, which could have a subsequent positive impact on mortality.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102203"},"PeriodicalIF":3.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impairments in geriatric assessment and their associations with different grip strength cutoffs and components of the Short Physical Performance Battery among older adults with cancer","authors":"Saul Cobbing ,&nbsp;Shabbir M.H. Alibhai ,&nbsp;Rana Jin ,&nbsp;Susie Monginot ,&nbsp;Efthymios Papadopoulos","doi":"10.1016/j.jgo.2025.102201","DOIUrl":"10.1016/j.jgo.2025.102201","url":null,"abstract":"<div><h3>Introduction</h3><div>The grip strength test is often used during geriatric assessment (GA) to assess muscle strength in older adults. However, it is unclear which grip strength cutoffs are most relevant to older adults in the context of GA. Physical performance during GA is often assessed via the Short Physical Performance Battery (SPPB). Whether the SPPB is superior to two of its individual components (4-m gait speed and the 5-chair stand test) for identifying GA abnormalities is unknown. The objectives of this study were (i) to identify which grip strength thresholds are associated with impairments in GA domains and with an abnormal GA overall and (ii) to examine whether total SPPB score is a stronger indicator of an abnormal GA and each of its domains than 4-m gait speed and the 5-chair stand test.</div></div><div><h3>Materials and Methods</h3><div>This was a retrospective cohort study of older adults with cancer aged ≥65 years who had undergone a GA prior to treatment. Grip strength and the SPPB were completed during GA. We examined three different grip strength cutoffs: (i) European Working Group on Sarcopenia in Older People 2 (EWGSOP2); (ii) the Foundation for the National Institutes of Health (FNIH); and (iii) the Sarcopenia Definitions and Outcomes Consortium (SDOC). Low SPPB was defined as a score of ≤9 out of 12 points. A score of ≤3 out of 4 points was used to identify abnormalities in the 4-m gait speed and 5-chair stand test. Multivariable logistic regression was used to address the study objectives.</div></div><div><h3>Results</h3><div>A total of 475 participants (mean age: 80.7 years, 42.9 % female) were included. The FNIH grip strength criteria had a higher discriminative ability of an abnormal GA (area under the curve [AUC] = 0.646) than the EWGSOP2 and the SDOC criteria. Compared to the SPPB and the 5-chair stand test, the 4-m gait speed was the strongest indicator of an abnormal GA (AUC = 0.737). The addition of low grip strength improved the performance of the SPPB (AUC Δ = +0.05) and gait speed (AUC Δ = +0.04) for identifying an abnormal GA.</div></div><div><h3>Discussion</h3><div>Low grip strength per the FNIH and slow gait speed are of clinical relevance during GA.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102201"},"PeriodicalIF":3.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}