Journal of geriatric oncology最新文献

Introduction: Older cancer survivors have an elevated risk for mobility dysfunction compared to their cancer-free peers. Despite the established link between cognitive function and community walking in older cancer-free adults, little is known about this relationship in older cancer survivors. This pilot study aimed to evaluate the association of performance-based and self-reported cognitive function with mobile metrics of community walking collected by a wearable Fitbit device.

Materials and methods: This study enrolled older cancer survivors (mean age 73 years old, range 65-83; 98 % White; 50 % female) within five years of completing primary treatment. Cognitive function, specifically executive function and processing speed was collected with the digit symbol substitution test (DSST) and self-reported cognition was evaluated by the Patient Reported Outcomes Measurement Information System- Cognitive (PROMIS-Cog). Continuous walking data from Fitbit wearable devices were collected passively over four weeks. To examine associations between DSST and PROMIS-Cog with mobile measures of walking, we conducted bivariate correlation and multivariable linear regression analyses adjusting for age, education, and number of comorbidities.

Results: In bivariate analyses, higher DSST scores were correlated with higher step count and peak cadence and lower fragmentation of walking in daily life (r = 0.48-0.51, p < 0.01). Higher PROMIS-Cog scores were correlated with higher peak cadence (r = 0.32, p < 0.05), trended towards correlation with step count (r = 0.30, p = 0.06), and were not correlated with fragmentation of walking (r = -0.24, p = 0.13). In multivariable models adjusting for age, presence of graduate level education, and number of comorbidities, higher DSST scores were independently associated with higher peak cadence, step count, and demonstrated a trend towards lower fragmentation of walking in daily life, but PROMIS-Cog was not independently associated with any mobility metrics. Similar results for association of DSST with walking when models included adjustment for PROMIS-depression scale, receipt of chemotherapy treatment, or when education was defined by presence of a bachelor's degree.

Discussion: This study suggests an association between cognitive functions of executive function and processing speed with mobile metrics of community walking in older cancer survivors. Understanding how cognitive function affects walking may help identify new rehabilitation targets for older cancer survivors.

Introduction: Sarcopenia is a common syndrome in older patients with advanced colorectal cancer that is worsened during standard-of-care chemotherapy and is associated with increased chemotherapy toxicity, impaired quality of life, and poorer survival independent of cancer stage or chemotherapy response. Physical activity and nutrition interventions have been shown to support muscle mass in patients recovering from treatment for early-stage colorectal cancer. The aim of this present review was to evaluate the effect of physical activity and nutritional interventions on sarcopenia in patients with advanced colorectal cancer.

Materials and methods: We performed a systematic literature review of studies investigating the impact of physical activity and nutritional interventions on muscle mass in patients with advanced colorectal cancer. Relevant key words were searched in appropriate databases through December 2022. Review procedures were performed in line with guidelines from the Cochrane Handbook for systematic reviews and Synthesis Without Meta-analysis (SWiM) guidelines.

Results: Twelve studies were identified with 1461 participants of which 587 had advanced colorectal cancer. Eight studies were randomised controlled trials (RCTs). Only two studies exclusively reported on the population with advanced colorectal cancer. Physical activity and nutritional interventions explored were heterogenous. Studies reporting an improvement in muscle mass utilised protein supplementation (one study), moderate intensity aerobic exercise (one study), and assisted resistance training (two studies). However, only a small number of participants with advanced colorectal cancer were included in these studies. Risk of bias was moderate to high for most studies. Recruitment to physical activity interventions was often low although adherence to supervised interventions was high. Physical activity and nutritional interventions across studies were safe.

Discussion: A small number of studies with limited sample size and moderate-to-high risk of bias suggest that assisted resistance training and supported protein intake improve muscle mass in participants with cancer. However, there is currently sparse evidence for the effect of physical activity and nutritional interventions on sarcopenia in the setting of advanced and incurable colorectal cancer. Given the impact of sarcopenia in this population, further research in this area is warranted.

The worldwide population is ageing, alongside an increase in cancer incidence rates. Over the past 10 years, there has been huge progress in the field of oncology with earlier diagnosis and an expansion of treatment options, leading to a growing number of older people living with cancer. That has meant that caring for older patients with cancer is now part of day-to-day oncology practices. This cohort often has geriatric syndromes and a higher prevalence of frailty and complex needs and preparing our clinical services to optimise care for these patients is essential. Whilst it is widely accepted that comprehensive geriatric assessments are of benefit to patients, only a small proportion of patients can access these through specialised teams during their cancer care. In the past few years there has been significant progress in this field throughout the United Kingdom (UK). The goal of this review is to inform other health care systems how to learn from what has been done in the UK. This paper provides an update from our previous review in 2020, detailing the new services being implemented and made available to patients and an expansion in the number of new pilot teams and research projects/trials throughout the four nations of the UK.

Introduction: This study aimed to evaluate the efficacy of perioperative dysphagia rehabilitation in older adult patients diagnosed with gastric cancer who underwent gastrectomy.

Materials and methods: This retrospective study included 149 patients over 80 years who underwent gastrectomies between January 2000 and December 2020. The patients were divided into two groups based on the intervention of the dysphagia rehabilitation team (DRT group: n = 101) and the non-intervention control group (C group: n = 48). Inverse probability weighting (IPW) analysis was used to reduce bias caused by potential confounding.

Results: The incidence of overall complications was significantly lower in the DRT group (odds ratio [OR]; 0.27[0.08-0.93]), among which the incidence of postoperative pneumonia (OR; 0.07[0.01-0.43]) and aspiration pneumonia (OR; 0.05[0.01-0.44] was significantly reduced. Ten patients developed postoperative pneumonia; seven were in the C group, and three were in DRT group. Sixty percent of these patients had preoperative comorbidities related to the respiratory system. Regarding the time of onset of aspiration pneumonia, two patterns were observed: onset within a short period after surgery and onset after the start of eating. In contrast, five patients underwent preoperative dysphagia rehabilitation in the DRT group. Among them, postoperative aspiration pneumonia was prevented in four patients, and the others were prevented from severe pneumonitis by the intervention of the dysphagia rehabilitation team.

Discussion: Perioperative intervention in dysphagia rehabilitation is not only associated with reduced postoperative pneumonia but also creates awareness in the medical staff and promotes careful observation of swallowing in patients, thereby controlling the incidence of postoperative pneumonia. The perioperative intervention of the dysphagia rehabilitation team is useful for older adult patients with gastric cancer.

Introduction: Frailty screening is important to guide treatment decisions for older patients with non-small cell lung cancer (NSCLC). However, the performance of frailty measures (FMs) remains unclear. This study aimed to evaluate the prognostic value of FMs based on electronic health records (EHR) data in clinical settings for all-cause mortality in older patients with NSCLC.

Materials and methods: We retrospectively analyzed 4253 patients aged ≥65 years, newly diagnosed with NSCLC (2007-2018) using EHR data from the National Cancer Center, Korea. Frailty was measured by either laboratory tests (frailty index based on routine laboratory tests [FI-Lab]), comorbidities and performance status (electronic Frailty index [eFI]), or both (combined frailty index [FI-combined]). Patients were categorized as frail or non-frail. Cox proportional hazards models and C-index were used to estimate the predictive ability of FMs for all-cause mortality in 1 year, 3 years, and 5 years post-diagnosis, adjusting for age, sex, and SEER stage.

Results: EHR-based FMs could enhance the prognostic ability to predict the survival of older patients with NSCLC. In the total population, FI-Lab showed the largest predictive value, especially for 1-year mortality with an adjusted hazard ratio for frail vs. non-frail groups of 2.25 (95 % CI 2.02-2.51) and C-index of 0.74 compared to 0.72 in the base model (p-value<0.001). FI-Lab could improve the prognostic ability for 1-year mortality in patients with regional and distant SEER stages and those receiving systemic therapy, whereas FI-combined could improve the prediction of 3-year and 5-year mortality in patients with localized disease and receiving surgery.

Discussion: Easy-to-use FMs derived from EHR data can enhance the prediction of all-cause mortality in older patients with NSCLC. Oncologists can utilize comprehensive FMs comprising comorbidities, functional status, and subclinical tests or FI-Lab, depending on the patient's medical condition, to facilitate shared cancer care planning.

Corticosteroids are used frequently in oncology and many patients require short- or long-term corticosteroid therapy. General clinical guidelines and recommendations exist on the use of corticosteroids; however, evidence is lacking for recommendations on their appropriate use in older adult with cancer. Treatment of chemotherapy-induced nausea and vomiting (CINV) has dramatically improved over the last decade with 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists and neurokinin-1 (NK-1) receptor antagonists or a combination of both. However, corticosteroids continue to play an important role in the management of acute and delayed CINV prevention. While highly efficacious, the toxicity profile of corticosteroids must be considered, particularly in heterogeneous older patients with multiple comorbidities and polypharmacy. Guidance on corticosteroid-reducing/sparing strategies in this specific population is needed. This consensus, supported by the International Society of Geriatric Oncology, aims to provide evidence-based recommendations for the use of corticosteroid therapy in older adults with cancer.