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Sustainability in university restaurants: a scoping review of evaluation focus and strategies. 大学餐厅的可持续性:评估重点和策略的范围审查。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-12 DOI: 10.1186/s41043-026-01288-9
Júlia Naves Peixoto, Marcela Gomes Reis, Beatriz Almeida Dantas, Paula Ribeiro Buarque, Izabela Maria Montezano de Carvalho, Nathalia Sernizon Guimarães

Introduction: Sustainability in food systems has been widely discussed due to the environmental, social and economic impacts of collective meal production. University restaurants play a strategic role due to the large volume of meals served daily, ensuring students' access to food security and serving as ideal environments for implementing sustainable practices. However, there are still gaps in the understanding of the main strategies adopted and the dimensions of sustainability most frequently assessed in these spaces.

Methods: This study carried out a scoping review, following the guidelines of the Joanna Briggs Institute (JBI) and writing according to PRISMA-SCR, with the aim of identifying the main sustainability strategies applied in university restaurants and mapping the stages of the production process most investigated in the scientific literature. The search was conducted in databases such as PubMed, Embase, Scopus, and the Virtual Health Library, and it included quantitative studies that evaluated aspects of sustainability in these restaurants. The extracted data was analyzed and categorized according to the principles of the 5Rs (Rethink, Reduce, Reuse, Recycle and Refuse).

Results: 58 studies were included, 52.54% from South America, with Brazil predominating. Most of the research focused on the post-distribution phase (70.69%), with a focus on waste management and food waste. The sustainability principle most frequently addressed was "Reduce" (91.4%), followed by "Rethink" (50%), while "Reuse" and "Refuse" were little explored. Strategies aimed at changing menus and educational campaigns targeting consumers were the predominant interventions.

Conclusion: Sustainability in university restaurants has been mostly addressed through waste reduction, with limited focus on structural changes and on the broader 5Rs framework. Future studies should integrate environmental strategies with nutritional adequacy, dietary quality, and student health to maximize the impact of sustainable initiatives in these settings.

导言:由于集体膳食生产对环境、社会和经济的影响,粮食系统的可持续性已被广泛讨论。由于每天供应大量的食物,大学餐厅发挥着战略作用,确保学生获得食品安全,并作为实施可持续实践的理想环境。然而,对这些空间中采用的主要战略和最常评估的可持续性方面的理解仍然存在差距。方法:本研究遵循乔安娜布里格斯研究所(JBI)的指导方针,根据PRISMA-SCR进行了范围审查,目的是确定大学餐厅应用的主要可持续发展战略,并绘制科学文献中研究最多的生产过程阶段。搜索是在PubMed、Embase、Scopus和虚拟健康图书馆等数据库中进行的,其中包括评估这些餐馆可持续性方面的定量研究。提取的数据根据5Rs (Rethink, Reduce, Reuse, Recycle和Refuse)的原则进行分析和分类。结果:共纳入58项研究,52.54%来自南美洲,以巴西为主。大部分研究集中在配送后阶段(70.69%),重点是废物管理和食物浪费。最常提到的可持续性原则是“减少”(91.4%),其次是“重新思考”(50%),而“再利用”和“垃圾”则很少被探讨。旨在改变菜单的战略和针对消费者的教育运动是主要的干预措施。结论:大学餐厅的可持续发展主要是通过减少浪费来解决的,对结构变化和更广泛的5r框架的关注有限。未来的研究应将环境策略与营养充足性、饮食质量和学生健康结合起来,以最大限度地发挥可持续举措在这些环境中的影响。
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引用次数: 0
The remnant cholesterol inflammatory index and risk of future cardiovascular disease in early CKM syndrome: findings from CHARLS. 早期CKM综合征的残余胆固醇炎症指数和未来心血管疾病的风险:来自CHARLS的发现
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-11 DOI: 10.1186/s41043-026-01286-x
Yue Yu, Yuemiao Jiao, Sanshuai Chang, Yang Li, Ke Shang, Guangyuan Song, Chengqian Yin

Background: Remnant cholesterol and systemic inflammation are two key, interrelated pathways in atherosclerosis. We examined whether the remnant cholesterol inflammatory index (RCII; remnant cholesterol × C-reactive protein/10) predicts incident cardiovascular disease (CVD) among adults in early cardiovascular-kidney-metabolic (CKM) stages.

Methods: We analyzed 5,961 China Health and Retirement Longitudinal Study participants aged ≥ 45 years (baseline 2015; follow-up through 2020) classified as CKM stages 0-3 and free of baseline CVD. Incident CVD (heart disease or stroke) was identified from self-reported physician diagnoses. We used multivariable Cox models with hierarchical adjustment, assessed dose-response patterns using restricted cubic splines, and conducted prespecified subgroup and exploratory mediation analyses.

Results: Over a median follow-up of 5.00 years (IQR, 5.00-5.09), 1,080 incident CVD occurred (18.1%). Each 1-unit increase in log-RCII was associated with higher CVD risk in the fully adjusted model (hazard ratio [HR] 1.070, 95% CI 1.016-1.127; P = 0.010). Compared with quartile 1, quartile 4 had increased risk (HR 1.239, 95% CI 1.029-1.492; P = 0.024; P for trend = 0.043). The dose-response association was linear (P for nonlinearity = 0.795), and no effect modification was detected (all P for interaction > 0.05). Systolic blood pressure mediated 5.0% (95% CI 1.10% to 17.00%) of the RCII-CVD association.

Conclusions: Higher RCII was modestly associated with incident CVD across early CKM stages, suggesting a simple research marker to identify individuals at higher risk during a prevention window. Standardized thresholds and external validation of incremental predictive value are needed before clinical use.

背景:残余胆固醇和全身性炎症是动脉粥样硬化的两个关键且相互关联的途径。我们研究了残余胆固醇炎症指数(RCII;残余胆固醇× c反应蛋白/10)是否能预测成人早期心血管-肾代谢(CKM)阶段心血管疾病(CVD)的发生。方法:我们分析了5961名年龄≥45岁(2015年基线;随访至2020年)的中国健康与退休纵向研究参与者,这些参与者被归类为CKM 0-3期和无基线CVD。心血管疾病(心脏病或中风)的发生率从自我报告的医师诊断中确定。我们使用分层调整的多变量Cox模型,使用受限三次样条评估剂量-反应模式,并进行预先指定的亚组和探索性中介分析。结果:中位随访5.00年(IQR, 5.00-5.09),发生1080例心血管疾病(18.1%)。在完全校正模型中,log-RCII每增加1个单位与心血管疾病风险升高相关(风险比[HR] 1.070, 95% CI 1.016-1.127; P = 0.010)。与四分位数1相比,四分位数4的风险增加(HR 1.239, 95% CI 1.029-1.492; P = 0.024;趋势P = 0.043)。剂量-反应呈线性相关(非线性P = 0.795),未发现效应修饰(相互作用P均为0.05)。收缩压介导了5.0% (95% CI 1.10% ~ 17.00%)的rci - cvd关联。结论:在早期CKM阶段,较高的RCII与心血管疾病的发生有一定的相关性,这表明在预防窗口期识别高危个体是一种简单的研究标记。临床应用前需要标准化的阈值和增量预测值的外部验证。
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引用次数: 0
Socio-demographic factors influencing obesity among ever-married Jordanian women of reproductive age: insights from the 2023 Jordan demographic and health survey. 影响约旦已婚育龄妇女肥胖的社会人口因素:来自2023年约旦人口与健康调查的见解。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-10 DOI: 10.1186/s41043-026-01273-2
Amr Ahmed Aly Ibrahim, Sara Hosny El-Farargy, Shadi Isac, Moaz Yasser Darwish, Mahmoud Shaaban Abdelgalil

Background: Obesity prevalence has been rising globally, including in Jordan. This study seeks to examine the socio-demographic factors associated with obesity among adult ever-married women in Jordan, utilizing the most recent data from the 2023 JPFHS.

Methods: This cross-sectional study analyzed data from the 2023 JDHS, encompassing a representative sample of 4,048 Jordanian women aged 15-49. Socioeconomic variables examined included age, education level, wealth index, urban or rural residence, and media consumption habits (television, radio, magazines/newspapers, internet usage) along with smoking status. Multivariate logistic regression was employed to determine the associations between these factors and obesity risk.

Results: Of the 4,048 married women included in the analysis, 1,697 (41.9%) had a normal BMI, while 2,351 (58.1%) were classified as obese. Multivariate analysis revealed that increasing age (45-49 years: AOR 20.93, 95% CI 13.40-32.70), daily internet use (AOR 1.33, 95% CI 1.02-1.74), listening to the radio less than once a week (AOR 1.40, 95% CI 1.03-1.91), and residing in Karak (AOR 2.13, 95% CI 1.34-3.38) or Ajloun (AOR 1.75, 95% CI 1.12-2.72) were significantly associated with higher odds of obesity. Conversely, reading newspapers or magazines at least once a week and daily cigarette smoking were linked to a reduced risk of obesity. No significant associations were observed between obesity and place of residence, wealth index, educational level, television viewing habits, or residence in other governorates.

Conclusion: With obesity rates continuing to rise, targeted health programs for Jordanian women of reproductive age are essential. National health initiatives should focus on promoting healthy lifestyle habits, addressing regional disparities, and encouraging balanced media consumption to mitigate obesity risk. Region-specific prevention and awareness campaigns are also vital for effective intervention.

背景:全球范围内,包括约旦在内,肥胖症患病率一直在上升。本研究旨在利用2023年JPFHS的最新数据,研究与约旦成年已婚妇女肥胖相关的社会人口因素。方法:这项横断面研究分析了2023年JDHS的数据,包括4048名年龄在15-49岁的约旦女性的代表性样本。研究的社会经济变量包括年龄、教育水平、财富指数、城市或农村居住、媒体消费习惯(电视、广播、杂志/报纸、互联网使用)以及吸烟状况。采用多变量logistic回归来确定这些因素与肥胖风险之间的关系。结果:在分析的4048名已婚女性中,有1697名(41.9%)BMI正常,而2351名(58.1%)被归类为肥胖。多因素分析显示,年龄增加(45-49岁:AOR 20.93, 95% CI 13.40-32.70)、每天使用互联网(AOR 1.33, 95% CI 1.02-1.74)、每周听广播少于一次(AOR 1.40, 95% CI 1.03-1.91)、居住在卡拉克(AOR 2.13, 95% CI 1.34-3.38)或Ajloun (AOR 1.75, 95% CI 1.12-2.72)与较高的肥胖几率显著相关。相反,每周至少阅读一次报纸或杂志以及每天吸烟与降低肥胖风险有关。没有观察到肥胖与居住地、财富指数、教育水平、看电视习惯或居住在其他省份之间的显著关联。结论:随着肥胖率的持续上升,为约旦育龄妇女制定有针对性的健康计划至关重要。国家卫生举措应侧重于促进健康的生活习惯,解决地区差异,并鼓励平衡的媒体消费,以减轻肥胖风险。针对特定区域的预防和提高认识运动对于有效干预也至关重要。
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引用次数: 0
Prevalence and associated factors of acute diarrhea among under-five children in community-led total sanitation and hygiene implemented and non-implemented kebeles in Chiro Woreda, Eastern Ethiopia. 埃塞俄比亚东部Chiro Woreda社区主导的实施和未实施全面环境卫生和个人卫生的kebeles中5岁以下儿童急性腹泻的流行情况及其相关因素
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-10 DOI: 10.1186/s41043-026-01284-z
Wondimagegn Wolde Eba, Getachew Gashaw, Kaleab Terefe, Abel Desalegn Demeke
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引用次数: 0
Machine learning-based prediction model for fall risk among individuals with arthritis in China: an analysis using the China Health and Retirement Longitudinal Study (CHARLS) database. 基于机器学习的中国关节炎患者跌倒风险预测模型:使用中国健康与退休纵向研究(CHARLS)数据库的分析
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-10 DOI: 10.1186/s41043-026-01283-0
Minglun Xiao, Ting Tan, Mao Liu

Background: Falling has become a global public health problem. Individuals with arthritis have a higher risk of falling because of joint pain, poor muscle strength, and decreased proprioception; however, there is no all-inclusive risk assessment model for fall risks in the Chinese population based on multi-health data.

Methods: This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) to develop a machine learning (ML)-based predictive model for fall risk among adults with arthritis. Multidimensional health data were integrated to identify key risk factors. Nine ML models, including XGBoost, were employed to assess predictive performance. The dataset was randomly divided into a training set (70%) and a test set (30%). Model performance was evaluated using AUC, calibration curves, and decision curve analysis, among other metrics.

Results: Among the 4,536 participants, 927 fall incidents were recorded, with a fall incidence rate of 20.44%. LASSO regression identified six key risk factors: age, sleep time, diabetes, depression, grip strength, and ADL score. The XGBoost model demonstrated the best performance, with AUC values of 0.746 (95% CI: 0.726-0.763) in the training set and 0.734 (95% CI: 0.702-0.768) in the test set. Calibration curves showed good agreement between predicted and observed probabilities, and decision curve analysis indicated significant clinical benefits.

Conclusion: The ML-based predictive model developed in this study effectively identifies fall risk among adults with arthritis, providing a valuable tool for clinical management and public health strategies. Further validation in external datasets is needed to confirm the model's generalizability and clinical utility.

背景:跌倒已成为一个全球性的公共卫生问题。患有关节炎的人摔倒的风险更高,因为关节疼痛、肌肉力量差和本体感觉下降;然而,目前尚无基于多卫生数据的全覆盖的中国人群跌倒风险评估模型。方法:本研究利用中国健康与退休纵向研究(CHARLS)的数据,开发了一个基于机器学习(ML)的成人关节炎患者跌倒风险预测模型。整合了多维健康数据,以确定关键风险因素。使用包括XGBoost在内的9个ML模型来评估预测性能。数据集随机分为训练集(70%)和测试集(30%)。使用AUC、校准曲线和决策曲线分析以及其他指标来评估模型性能。结果:在4,536名参与者中,记录了927起跌倒事件,跌倒发生率为20.44%。LASSO回归确定了六个关键风险因素:年龄、睡眠时间、糖尿病、抑郁、握力和ADL评分。XGBoost模型表现出最好的性能,训练集的AUC值为0.746 (95% CI: 0.726-0.763),测试集的AUC值为0.734 (95% CI: 0.702-0.768)。校正曲线显示预测概率与观测概率吻合良好,决策曲线分析显示临床获益显著。结论:本研究建立的基于ml的预测模型有效地识别了成人关节炎患者的跌倒风险,为临床管理和公共卫生策略提供了有价值的工具。需要在外部数据集中进一步验证以确认该模型的通用性和临床实用性。
{"title":"Machine learning-based prediction model for fall risk among individuals with arthritis in China: an analysis using the China Health and Retirement Longitudinal Study (CHARLS) database.","authors":"Minglun Xiao, Ting Tan, Mao Liu","doi":"10.1186/s41043-026-01283-0","DOIUrl":"https://doi.org/10.1186/s41043-026-01283-0","url":null,"abstract":"<p><strong>Background: </strong>Falling has become a global public health problem. Individuals with arthritis have a higher risk of falling because of joint pain, poor muscle strength, and decreased proprioception; however, there is no all-inclusive risk assessment model for fall risks in the Chinese population based on multi-health data.</p><p><strong>Methods: </strong>This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) to develop a machine learning (ML)-based predictive model for fall risk among adults with arthritis. Multidimensional health data were integrated to identify key risk factors. Nine ML models, including XGBoost, were employed to assess predictive performance. The dataset was randomly divided into a training set (70%) and a test set (30%). Model performance was evaluated using AUC, calibration curves, and decision curve analysis, among other metrics.</p><p><strong>Results: </strong>Among the 4,536 participants, 927 fall incidents were recorded, with a fall incidence rate of 20.44%. LASSO regression identified six key risk factors: age, sleep time, diabetes, depression, grip strength, and ADL score. The XGBoost model demonstrated the best performance, with AUC values of 0.746 (95% CI: 0.726-0.763) in the training set and 0.734 (95% CI: 0.702-0.768) in the test set. Calibration curves showed good agreement between predicted and observed probabilities, and decision curve analysis indicated significant clinical benefits.</p><p><strong>Conclusion: </strong>The ML-based predictive model developed in this study effectively identifies fall risk among adults with arthritis, providing a valuable tool for clinical management and public health strategies. Further validation in external datasets is needed to confirm the model's generalizability and clinical utility.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global burden of disease and future trends of trichomoniasis in women of reproductive age from 1990 to 2021. 1990年至2021年育龄妇女滴虫病的全球疾病负担和未来趋势。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-09 DOI: 10.1186/s41043-026-01262-5
Yuxuan Jin, Yudi Tan, Shuyi Huang, Yong Wang, Shasha Yang, Jinkong Wei, Yuying Wei, Yongcen Zhou, Yi Huang, Caiyi He, Junying Chen
{"title":"Global burden of disease and future trends of trichomoniasis in women of reproductive age from 1990 to 2021.","authors":"Yuxuan Jin, Yudi Tan, Shuyi Huang, Yong Wang, Shasha Yang, Jinkong Wei, Yuying Wei, Yongcen Zhou, Yi Huang, Caiyi He, Junying Chen","doi":"10.1186/s41043-026-01262-5","DOIUrl":"https://doi.org/10.1186/s41043-026-01262-5","url":null,"abstract":"","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Residual inflammatory risk as a predictor of cardiometabolic multi-morbidity: results from three prospective cohorts. 残余炎症风险作为心脏代谢多病的预测因子:来自三个前瞻性队列的结果。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-09 DOI: 10.1186/s41043-026-01269-y
Shihai Wang, Xiaobin Zeng, Jianjun Lan, Shiyang Li

Background: Inflammation and its dynamic changes are intricately linked to cardiovascular diseases. This research aimed to explore the predictive significance of residual inflammatory risk (RIR) in evaluating the likelihood of developing cardiometabolic multi-morbidity (CMM).

Methods: Data were sourced from the China Health and Retirement Longitudinal Study (CHARLS), the Health and Retirement Study (HRS) and panzhihua central hospital. Inflammation status was assessed using at least two high-sensitivity C-reactive protein (hsCRP) measurements taken at baseline and follow-up, with a minimum interval of four weeks. High RIR was characterized by an hsCRP level exceeding 2 mg/L. Participants were categorized into four groups: persistent high RIR, increased RIR (initially low, subsequently high hsCRP), attenuated RIR (initially high, subsequently low hsCRP), and persistent low RIR. Multivariable Cox proportional hazards regression and subgroup analyses were employed to examine the relationship between RIR and CMM.

Results: The study included 5,572 participants from the CHARLS (56.26% female, mean age 57.87 years), 3,856 participants from the HRS (60.35% female, mean age 65.74 years), and 2,446 participants from the panzhihua central hospital (54.17% female, mean age 58.65 years). Utilizing Cox proportional hazards regression, participants with persistent high RIR exhibited a significant association with an increased risk of developing CMM compared to those with persistent low RIR (CHARLS: HR = 2.2, 95% CI = 1.79-2.69, P < 0.001; HRS: HR = 1.79, 95% CI = 1.47-2.18, P < 0.001; panzhihua cohort: HR = 3.97, 95% CI = 2.52-6.27, P < 0.001). This association persisted after comprehensive adjustment for potential confounders (CHARLS: HR = 1.81, 95% CI = 1.47-2.23, P < 0.001; HRS: HR = 1.69, 95% CI = 1.38-2.08, P < 0.001; panzhihua cohort: HR = 3.74, 95% CI = 2.34-5.99, P < 0.001). Subgroup analyses further confirmed the robustness of the association between persistent high RIR and CMM across all examined subgroups.

Conclusion: Persistent high RIR was correlated with an increased risk of CMM. Future research is needed to determine whether anti-inflammatory strategies targeting RIR reduction could mitigate CMM risk.

背景:炎症及其动态变化与心血管疾病有着复杂的联系。本研究旨在探讨残余炎症风险(RIR)在评估发生心脏代谢多发病(CMM)可能性中的预测意义。方法:数据来源于中国健康与退休纵向研究(CHARLS)、健康与退休研究(HRS)和攀枝花市中心医院。在基线和随访期间,使用至少两次高灵敏度c反应蛋白(hsCRP)测量来评估炎症状态,至少间隔四周。高RIR的特征是hsCRP水平超过2 mg/L。参与者被分为四组:持续高RIR,增加RIR(最初低,随后高hsCRP),减弱RIR(最初高,随后低hsCRP)和持续低RIR。采用多变量Cox比例风险回归和亚组分析检验RIR与CMM的关系。结果:本研究纳入CHARLS 5572例(女性56.26%,平均年龄57.87岁),HRS 3856例(女性60.35%,平均年龄65.74岁),攀枝花中心医院2446例(女性54.17%,平均年龄58.65岁)。利用Cox比例风险回归,与持续低RIR的参与者相比,持续高RIR的参与者与发生CMM的风险增加显著相关(CHARLS: HR = 2.2, 95% CI = 1.79-2.69, P)。结论:持续高RIR与CMM的风险增加相关。未来的研究需要确定针对RIR降低的抗炎策略是否可以减轻CMM风险。
{"title":"Residual inflammatory risk as a predictor of cardiometabolic multi-morbidity: results from three prospective cohorts.","authors":"Shihai Wang, Xiaobin Zeng, Jianjun Lan, Shiyang Li","doi":"10.1186/s41043-026-01269-y","DOIUrl":"https://doi.org/10.1186/s41043-026-01269-y","url":null,"abstract":"<p><strong>Background: </strong>Inflammation and its dynamic changes are intricately linked to cardiovascular diseases. This research aimed to explore the predictive significance of residual inflammatory risk (RIR) in evaluating the likelihood of developing cardiometabolic multi-morbidity (CMM).</p><p><strong>Methods: </strong>Data were sourced from the China Health and Retirement Longitudinal Study (CHARLS), the Health and Retirement Study (HRS) and panzhihua central hospital. Inflammation status was assessed using at least two high-sensitivity C-reactive protein (hsCRP) measurements taken at baseline and follow-up, with a minimum interval of four weeks. High RIR was characterized by an hsCRP level exceeding 2 mg/L. Participants were categorized into four groups: persistent high RIR, increased RIR (initially low, subsequently high hsCRP), attenuated RIR (initially high, subsequently low hsCRP), and persistent low RIR. Multivariable Cox proportional hazards regression and subgroup analyses were employed to examine the relationship between RIR and CMM.</p><p><strong>Results: </strong>The study included 5,572 participants from the CHARLS (56.26% female, mean age 57.87 years), 3,856 participants from the HRS (60.35% female, mean age 65.74 years), and 2,446 participants from the panzhihua central hospital (54.17% female, mean age 58.65 years). Utilizing Cox proportional hazards regression, participants with persistent high RIR exhibited a significant association with an increased risk of developing CMM compared to those with persistent low RIR (CHARLS: HR = 2.2, 95% CI = 1.79-2.69, P < 0.001; HRS: HR = 1.79, 95% CI = 1.47-2.18, P < 0.001; panzhihua cohort: HR = 3.97, 95% CI = 2.52-6.27, P < 0.001). This association persisted after comprehensive adjustment for potential confounders (CHARLS: HR = 1.81, 95% CI = 1.47-2.23, P < 0.001; HRS: HR = 1.69, 95% CI = 1.38-2.08, P < 0.001; panzhihua cohort: HR = 3.74, 95% CI = 2.34-5.99, P < 0.001). Subgroup analyses further confirmed the robustness of the association between persistent high RIR and CMM across all examined subgroups.</p><p><strong>Conclusion: </strong>Persistent high RIR was correlated with an increased risk of CMM. Future research is needed to determine whether anti-inflammatory strategies targeting RIR reduction could mitigate CMM risk.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of the composite dietary antioxidant index with the risk of cardiometabolic disorders: findings from the Tehran Lipid and Glucose Study. 复合膳食抗氧化指数与心脏代谢紊乱风险的关系:来自德黑兰脂质和葡萄糖研究的发现
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-08 DOI: 10.1186/s41043-026-01282-1
Hamid Ahmadirad, Hossein Farhadnejad, Niloufar Saber, Mitra Kazemi Jahromi, Farshad Teymoori, Parvin Mirmiran, Fereidoun Azizi

Background/objective: Dietary antioxidants have been suggested to play a protective role against chronic diseases. This prospective study aimed to examine the association between the composite dietary antioxidant index (CDAI) and the risk of type 2 diabetes (T2D), hypertension, and abdominal obesity.

Methods: This prospective cohort study included 7357 adults aged ≥ 18 years who participated in the third and fourth phases of the Tehran Lipid and Glucose Study. Dietary intake was assessed using a validated 168-item food frequency questionnaire, and CDAI scores were calculated accordingly. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for T2D, hypertension, and abdominal obesity across quartiles of CDAI.

Results: During the follow-up period, the incidence rates were 12.5% for T2D (mean follow-up: 10.8 ± 3.64 years), 23.4% for hypertension (mean follow-up: 10.0 ± 4.09 years), and 33.5% for abdominal obesity (mean follow-up: 10.1 ± 4.29 years). After adjustment for age, sex, physical activity, energy intake, education, marital and occupational status, smoking, and outcome-specific baseline clinical variables, higher CDAI scores were associated with a lower risk of T2D (HR = 0.68; 95% CI: 0.48-0.96; P for trend = 0.025), hypertension (HR = 0.65; 95% CI: 0.52-0.83; P for trend = 0.014), and abdominal obesity (HR = 0.53; 95% CI: 0.42-0.68; P for trend < 0.001).

Conclusions: Higher adherence to a diet with greater antioxidant capacity, as reflected by higher CDAI scores, may be related to a reduced risk of T2D, hypertension, and abdominal obesity among Iranian adults.

背景/目的:膳食抗氧化剂已被认为对慢性疾病具有保护作用。本前瞻性研究旨在探讨复合膳食抗氧化指数(CDAI)与2型糖尿病(T2D)、高血压和腹部肥胖风险之间的关系。方法:这项前瞻性队列研究包括7357名年龄≥18岁的成年人,他们参加了德黑兰脂质和葡萄糖研究的第三和第四期。使用经过验证的168项食物频率问卷评估膳食摄入量,并据此计算CDAI评分。采用多变量校正Cox比例风险模型来估计CDAI四分位数中T2D、高血压和腹部肥胖的风险比(hr)和95%置信区间(ci)。结果:随访期间,T2D发生率为12.5%(平均随访时间:10.8±3.64年),高血压发生率为23.4%(平均随访时间:10.0±4.09年),腹部肥胖发生率为33.5%(平均随访时间:10.1±4.29年)。在调整了年龄、性别、体力活动、能量摄入、教育程度、婚姻和职业状况、吸烟和结局特定基线临床变量后,较高的CDAI评分与较低的T2D (HR = 0.68; 95% CI: 0.48-0.96; P为趋势= 0.025)、高血压(HR = 0.65; 95% CI: 0.52-0.83; P为趋势= 0.014)和腹部肥胖(HR = 0.53; 95% CI: 0.42-0.68;结论:正如较高的CDAI评分所反映的那样,较高的抗氧化能力饮食依从性可能与伊朗成年人中T2D、高血压和腹部肥胖风险降低有关。
{"title":"The association of the composite dietary antioxidant index with the risk of cardiometabolic disorders: findings from the Tehran Lipid and Glucose Study.","authors":"Hamid Ahmadirad, Hossein Farhadnejad, Niloufar Saber, Mitra Kazemi Jahromi, Farshad Teymoori, Parvin Mirmiran, Fereidoun Azizi","doi":"10.1186/s41043-026-01282-1","DOIUrl":"https://doi.org/10.1186/s41043-026-01282-1","url":null,"abstract":"<p><strong>Background/objective: </strong>Dietary antioxidants have been suggested to play a protective role against chronic diseases. This prospective study aimed to examine the association between the composite dietary antioxidant index (CDAI) and the risk of type 2 diabetes (T2D), hypertension, and abdominal obesity.</p><p><strong>Methods: </strong>This prospective cohort study included 7357 adults aged ≥ 18 years who participated in the third and fourth phases of the Tehran Lipid and Glucose Study. Dietary intake was assessed using a validated 168-item food frequency questionnaire, and CDAI scores were calculated accordingly. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for T2D, hypertension, and abdominal obesity across quartiles of CDAI.</p><p><strong>Results: </strong>During the follow-up period, the incidence rates were 12.5% for T2D (mean follow-up: 10.8 ± 3.64 years), 23.4% for hypertension (mean follow-up: 10.0 ± 4.09 years), and 33.5% for abdominal obesity (mean follow-up: 10.1 ± 4.29 years). After adjustment for age, sex, physical activity, energy intake, education, marital and occupational status, smoking, and outcome-specific baseline clinical variables, higher CDAI scores were associated with a lower risk of T2D (HR = 0.68; 95% CI: 0.48-0.96; P for trend = 0.025), hypertension (HR = 0.65; 95% CI: 0.52-0.83; P for trend = 0.014), and abdominal obesity (HR = 0.53; 95% CI: 0.42-0.68; P for trend < 0.001).</p><p><strong>Conclusions: </strong>Higher adherence to a diet with greater antioxidant capacity, as reflected by higher CDAI scores, may be related to a reduced risk of T2D, hypertension, and abdominal obesity among Iranian adults.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Underweight is associated with detectable viral load among adolescents with HIV in rural eastern Uganda: a retrospective cohort study. 乌干达东部农村地区携带艾滋病毒的青少年体重不足与可检测的病毒载量有关:一项回顾性队列研究。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-08 DOI: 10.1186/s41043-026-01280-3
Agnes Auca, Barbara Shalah Logose, Jonathan Izudi

Background: Detectable viral load (DVL) after ≥ 6 months of antiretroviral therapy (ART) and underweight are common among adolescents with HIV (AWH) but remain understudied. We assessed the association between underweight at ART initiation and DVL among AWH in rural eastern Uganda.

Methods: We retrospectively reviewed program data for AWH aged 10-19 years from 11 clinics in eight districts. Underweight was defined as body mass index (BMI) for age <5th percentile at ART initiation. DVL was defined as the first viral load ≥ 1,000 copies/mL after ≥ 6 months on ART. Associations were examined using multi-level mixed-effects Poisson regression, adjusting for individual-level factors and accounting for clustering by district and health facility.

Results: We analyzed 525 AWH, of whom 47.6% were aged 10-14 years and 51.0% were male. At ART initiation, 79.2% were underweight, and 19.0% had DVL after ≥ 6 months on ART. In multivariable analysis, underweight at ART initiation was significantly associated with DVL (adjusted risk ratio [aRR] 1.66, 95% confidence interval [CI] 1.07-2.56). DVL was also associated with baseline CD4 count ≤ 200 cells/µL (aRR 1.36, 95% CI 1.12-1.66), and there was no statistically significant association with interruption in ART (aRR 1.43, 95% CI 0.89-2.29).

Conclusion: Among AWH in rural eastern Uganda, the prevalence of DVL was nearly four times the UNAIDS target of ≤ 5%. DVL was linked to underweight and severe immunodeficiency. Interventions such as nutritional support, targeted adherence counseling, early HIV diagnosis, and prompt ART initiation are critical to achieving viral suppression in this setting.

背景:抗逆转录病毒治疗(ART)≥6个月后可检测的病毒载量(DVL)和体重不足在青少年HIV (AWH)中很常见,但仍未得到充分研究。我们评估了乌干达东部农村地区AWH患者开始抗逆转录病毒治疗时体重不足与DVL之间的关系。方法:我们回顾性地回顾了来自8个地区11个诊所的10-19岁AWH项目数据。结果:我们分析了525名AWH,其中47.6%的患者年龄在10-14岁之间,51.0%为男性。在抗逆转录病毒治疗开始时,79.2%体重过轻,19.0%在抗逆转录病毒治疗≥6个月后出现DVL。在多变量分析中,ART开始时体重不足与DVL显著相关(调整风险比[aRR] 1.66, 95%可信区间[CI] 1.07-2.56)。DVL也与基线CD4计数≤200个细胞/µL相关(aRR 1.36, 95% CI 1.12-1.66),与ART中断无统计学意义关联(aRR 1.43, 95% CI 0.89-2.29)。结论:乌干达东部农村AWH中,DVL患病率是联合国艾滋病规划署≤5%目标的近4倍。DVL与体重不足和严重免疫缺陷有关。在这种情况下,营养支持、有针对性的依从性咨询、艾滋病毒早期诊断和及时开始抗逆转录病毒治疗等干预措施对于实现病毒抑制至关重要。
{"title":"Underweight is associated with detectable viral load among adolescents with HIV in rural eastern Uganda: a retrospective cohort study.","authors":"Agnes Auca, Barbara Shalah Logose, Jonathan Izudi","doi":"10.1186/s41043-026-01280-3","DOIUrl":"https://doi.org/10.1186/s41043-026-01280-3","url":null,"abstract":"<p><strong>Background: </strong>Detectable viral load (DVL) after ≥ 6 months of antiretroviral therapy (ART) and underweight are common among adolescents with HIV (AWH) but remain understudied. We assessed the association between underweight at ART initiation and DVL among AWH in rural eastern Uganda.</p><p><strong>Methods: </strong>We retrospectively reviewed program data for AWH aged 10-19 years from 11 clinics in eight districts. Underweight was defined as body mass index (BMI) for age <5th percentile at ART initiation. DVL was defined as the first viral load ≥ 1,000 copies/mL after ≥ 6 months on ART. Associations were examined using multi-level mixed-effects Poisson regression, adjusting for individual-level factors and accounting for clustering by district and health facility.</p><p><strong>Results: </strong>We analyzed 525 AWH, of whom 47.6% were aged 10-14 years and 51.0% were male. At ART initiation, 79.2% were underweight, and 19.0% had DVL after ≥ 6 months on ART. In multivariable analysis, underweight at ART initiation was significantly associated with DVL (adjusted risk ratio [aRR] 1.66, 95% confidence interval [CI] 1.07-2.56). DVL was also associated with baseline CD4 count ≤ 200 cells/µL (aRR 1.36, 95% CI 1.12-1.66), and there was no statistically significant association with interruption in ART (aRR 1.43, 95% CI 0.89-2.29).</p><p><strong>Conclusion: </strong>Among AWH in rural eastern Uganda, the prevalence of DVL was nearly four times the UNAIDS target of ≤ 5%. DVL was linked to underweight and severe immunodeficiency. Interventions such as nutritional support, targeted adherence counseling, early HIV diagnosis, and prompt ART initiation are critical to achieving viral suppression in this setting.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fasting blood glucose trajectories and atherosclerosis risk: a longitudinal cohort study with threshold analysis in Chongqing, China. 空腹血糖轨迹与动脉粥样硬化风险:中国重庆纵向队列研究与阈值分析。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-05 DOI: 10.1186/s41043-025-01193-7
Na Li, Chun-Mei Fei, Feng Tang, Xian-Shu Lin, Bing-Rui Yang, Jun Guo, Li-An-Sheng Wu, Yin-Yin Xia, Chuan Zhang, Li Xu

Background: Atherosclerosis, the primary pathological basis of cardiovascular diseases, exhibits a strong association with glucose metabolism dysregulation. While cross-sectional studies have linked fasting blood glucose (FBG) to atherosclerosis risk, the dose-response relationship and threshold characteristics of long-term FBG trajectories remain poorly characterized. This retrospective cohort study aimed to investigate longitudinal FBG trajectory patterns and their associations with atherosclerosis risk prevalence, incidence, and recovery in Chongqing, China, while also identifying population-specific risk thresholds.

Methods: Based on the three-year longitudinal follow-up data collected annually from 2017 to 2019, a population-based trajectory model (GBTM) was adopted to identify the dynamic trajectory of FBG. The association between FBG and atherosclerosis risk was analyzed using multivariable logistic regression. Restricted cubic splines (RCS) were used to assess the non-linear relationship between FBG and atherosclerosis risk and to determine risk thresholds. Confounding factors such as age, sex, body mass index (BMI), blood pressure, and lipids were adjusted for in the regression models, and subgroup analyses were performed to examine the interactions of age, sex, and BMI.

Results: Longitudinal analysis showed that compared with the Trajectory Normal Glucose Regulation (NGR) group, the Trajectory Prediabetes Mellitus group (Pre-DM) group had significantly higher prevalence (OR: 2.02, 95% CI: 1.63-2.51) and incidence (OR: 1.66, 95% CI: 1.15-2.39) of atherosclerosis risk. The Trajectory Pre-DM group also had a significantly lower likelihood of atherosclerosis risk recovery than the Trajectory NGR group (OR: 0.55, 95% CI: 0.39-0.79). Dose-response analysis revealed a non-linear association between FBG and atherosclerosis risk prevalence, with a risk threshold at 5.10 mmol/L. This suggests that the atherosclerosis risk threshold in Chongqing is significantly lower than the international prediabetes standard of 5.60 mmol/L. Subgroup analyses showed sex and age differences, with lower thresholds in women and younger individuals.

Conclusions: Long-term elevation of FBG was associated with increased atherosclerosis risk. The study suggests that intervention strategies should be based on dynamic blood glucose trajectories and population-specific thresholds, especially lower thresholds for women and younger individuals. This study provides evidence-based support for regional atherosclerosis risk prevention and control.

背景:动脉粥样硬化是心血管疾病的主要病理基础,与糖代谢异常密切相关。虽然横断面研究已经将空腹血糖(FBG)与动脉粥样硬化风险联系起来,但长期FBG轨迹的剂量-反应关系和阈值特征仍然缺乏特征。本回顾性队列研究旨在调查重庆纵向FBG轨迹模式及其与动脉粥样硬化风险患病率、发病率和恢复的关系,同时确定人群特异性风险阈值。方法:基于2017 - 2019年每年采集的3年纵向随访数据,采用基于人群的轨迹模型(GBTM)识别FBG的动态轨迹。采用多变量logistic回归分析空腹血糖与动脉粥样硬化风险之间的关系。限制三次样条(RCS)用于评估空腹血糖与动脉粥样硬化风险之间的非线性关系,并确定风险阈值。在回归模型中调整了年龄、性别、体重指数(BMI)、血压和血脂等混杂因素,并进行亚组分析以检查年龄、性别和BMI之间的相互作用。结果:纵向分析显示,与轨迹正常血糖调节(NGR)组相比,轨迹糖尿病前期(Pre-DM)组动脉粥样硬化风险患病率(OR: 2.02, 95% CI: 1.63-2.51)和发生率(OR: 1.66, 95% CI: 1.15-2.39)显著高于轨迹糖尿病前期组。与轨道NGR组相比,轨道糖尿病前期组动脉粥样硬化风险恢复的可能性也显著降低(OR: 0.55, 95% CI: 0.39-0.79)。剂量-反应分析显示,空腹血糖与动脉粥样硬化风险患病率呈非线性关系,风险阈值为5.10 mmol/L。这表明重庆地区动脉粥样硬化危险阈值明显低于国际糖尿病前期标准5.60 mmol/L。亚组分析显示了性别和年龄差异,女性和年轻人的阈值较低。结论:空腹血糖长期升高与动脉粥样硬化风险增加有关。该研究表明,干预策略应基于动态血糖轨迹和人群特异性阈值,特别是女性和年轻人的较低阈值。本研究为区域动脉粥样硬化风险防控提供循证支持。
{"title":"Fasting blood glucose trajectories and atherosclerosis risk: a longitudinal cohort study with threshold analysis in Chongqing, China.","authors":"Na Li, Chun-Mei Fei, Feng Tang, Xian-Shu Lin, Bing-Rui Yang, Jun Guo, Li-An-Sheng Wu, Yin-Yin Xia, Chuan Zhang, Li Xu","doi":"10.1186/s41043-025-01193-7","DOIUrl":"https://doi.org/10.1186/s41043-025-01193-7","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis, the primary pathological basis of cardiovascular diseases, exhibits a strong association with glucose metabolism dysregulation. While cross-sectional studies have linked fasting blood glucose (FBG) to atherosclerosis risk, the dose-response relationship and threshold characteristics of long-term FBG trajectories remain poorly characterized. This retrospective cohort study aimed to investigate longitudinal FBG trajectory patterns and their associations with atherosclerosis risk prevalence, incidence, and recovery in Chongqing, China, while also identifying population-specific risk thresholds.</p><p><strong>Methods: </strong>Based on the three-year longitudinal follow-up data collected annually from 2017 to 2019, a population-based trajectory model (GBTM) was adopted to identify the dynamic trajectory of FBG. The association between FBG and atherosclerosis risk was analyzed using multivariable logistic regression. Restricted cubic splines (RCS) were used to assess the non-linear relationship between FBG and atherosclerosis risk and to determine risk thresholds. Confounding factors such as age, sex, body mass index (BMI), blood pressure, and lipids were adjusted for in the regression models, and subgroup analyses were performed to examine the interactions of age, sex, and BMI.</p><p><strong>Results: </strong>Longitudinal analysis showed that compared with the Trajectory Normal Glucose Regulation (NGR) group, the Trajectory Prediabetes Mellitus group (Pre-DM) group had significantly higher prevalence (OR: 2.02, 95% CI: 1.63-2.51) and incidence (OR: 1.66, 95% CI: 1.15-2.39) of atherosclerosis risk. The Trajectory Pre-DM group also had a significantly lower likelihood of atherosclerosis risk recovery than the Trajectory NGR group (OR: 0.55, 95% CI: 0.39-0.79). Dose-response analysis revealed a non-linear association between FBG and atherosclerosis risk prevalence, with a risk threshold at 5.10 mmol/L. This suggests that the atherosclerosis risk threshold in Chongqing is significantly lower than the international prediabetes standard of 5.60 mmol/L. Subgroup analyses showed sex and age differences, with lower thresholds in women and younger individuals.</p><p><strong>Conclusions: </strong>Long-term elevation of FBG was associated with increased atherosclerosis risk. The study suggests that intervention strategies should be based on dynamic blood glucose trajectories and population-specific thresholds, especially lower thresholds for women and younger individuals. This study provides evidence-based support for regional atherosclerosis risk prevention and control.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Health, Population, and Nutrition
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