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Residential inequalities in hypertension medication use: a multivariate non-linear decomposition analysis. 高血压药物使用的居民不平等:多变量非线性分解分析。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-28 DOI: 10.1186/s41043-025-01207-4
Joshua Okyere, Castro Ayebeng, Kwamena Sekyi Dickson
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引用次数: 0
On-the-ground realities of health program delivery in addressing community needs: a community-based participatory research approach in the moose Cree First Nation. 解决社区需求的卫生方案交付的实际情况:驼鹿族第一民族的社区参与性研究方法。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-27 DOI: 10.1186/s41043-025-01196-4
Trisia Mae F Balalio, Michael A Robidoux

Background: It has been well documented that Indigenous people in northern remote communities in Canada continue to experience a disproportionate burden of health disparities due to complex interactions of multiple determinants of health, including food insecurity, colonialism, barriers in accessing primary healthcare, and disrupted socioeconomic and political structures. Health promotion programs are essential in building preventive measures and empowering communities to take control over their health by helping them make informed health choices. This study described Indigenous-led nutrition-related health programs, the Healthy Babies, Healthy Children Program (HBHCP) and the Diabetes Prevention Program (DPP), which respond to food insecurity drivers and support community needs in Moose Cree First Nation (MCFN). It also documented the on-the-ground realities of program delivery and highlighted community-informed priorities for improved programming.

Methods: Grounded in community-based participatory research (CBPR) principles, our approach emphasized the importance of community engagement in supporting the healing process within this cultural context. Data collection included first-hand participation in program delivery alongside program coordinators, participant feedback, and semi-structured interviews from community members (n = 6) and Health Center staff (n = 3). Thematic analysis was used to identify themes across interview data, field notes, and community feedback.

Results: High food costs, limited access and availability, and poor food quality remain the primary food-related challenges experienced in the community. Health programs serve as frontline responders to community needs and address these challenges through culturally grounded and family-oriented nutrition education activities. Community members valued the programs' knowledge-sharing approaches, tangible support, and social connections. However, systemic barriers significantly constrain program delivery, including inadequate funding, limited resources, staffing shortages, and the impact of COVID-19. These barriers limited the programs' capacity to reach their full potential, despite strong community resilience.

Conclusion: Indigenous-led nutrition programs are vital in addressing food insecurity and promoting health in northern communities. The findings underscore the need for sustainable funding and stronger policy support that reflects the true cost of service delivery in remote Indigenous communities. The findings emphasize the need for policy changes that move beyond top-down approaches toward community-informed policies and Indigenous-led health programming.

背景:有充分证据表明,由于多种健康决定因素的复杂相互作用,包括粮食不安全、殖民主义、获得初级保健方面的障碍以及社会经济和政治结构的破坏,加拿大北部偏远社区的土著人民继续承受着不成比例的健康差距负担。健康促进规划对于建立预防措施和授权社区通过帮助他们做出知情的健康选择来控制自己的健康至关重要。本研究描述了土著主导的营养相关健康计划,健康婴儿,健康儿童计划(hbbhcp)和糖尿病预防计划(DPP),这些计划应对驼鹿Cree第一民族(MCFN)的粮食不安全驱动因素并支持社区需求。它还记录了项目实施的实际情况,并强调了在社区知情的情况下改进项目的优先事项。方法:基于基于社区的参与性研究(CBPR)原则,我们的方法强调了在这种文化背景下社区参与对支持治疗过程的重要性。数据收集包括与项目协调员一起参与项目实施的第一手资料、参与者反馈以及来自社区成员(n = 6)和卫生中心工作人员(n = 3)的半结构化访谈。主题分析用于从访谈数据、实地记录和社区反馈中确定主题。结果:食品成本高、获取和供应有限以及食品质量差仍然是社区面临的主要食品相关挑战。卫生项目作为社区需求的一线反应者,通过以文化为基础和以家庭为导向的营养教育活动来应对这些挑战。社区成员对项目的知识共享方式、切实支持和社会联系表示重视。然而,系统性障碍严重制约了项目的实施,包括资金不足、资源有限、人员短缺和COVID-19的影响。这些障碍限制了项目充分发挥潜力的能力,尽管社区抵御能力很强。结论:土著主导的营养方案对于解决北方社区的粮食不安全和促进健康至关重要。调查结果强调需要可持续的资金和更强有力的政策支持,以反映偏远土著社区提供服务的真实成本。调查结果强调需要改变政策,超越自上而下的做法,转向社区知情的政策和土著主导的保健规划。
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引用次数: 0
Initial different human papillomavirus infection statuses and subsequent infection risk: a decade-long longitudinal study. 最初不同的人乳头瘤病毒感染状态和随后的感染风险:一项长达十年的纵向研究
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-26 DOI: 10.1186/s41043-025-01202-9
Han Zheng, Mengdan Gao, Hongyan Xu, Jingfen Cai, Zhenhong Wu, Yanfang Gu

Background: HPV infection is a major risk factor for cervical cancer. HPV vaccine coverage remains low. Early identification of high-risk individuals with some characteristics is crucial for those with limited vaccination access.

Objective: To estimate the impact of different HPV infection statuses on subsequent infection, infection type, and coinfection. Influencing factors of long-term HPV infection status and clearance were also explored.

Methods: Data from Wuxi's cervical cancer screening (2013-2022) was used. Multivariate and multinomial logistic regression models were used to evaluate the relationship between different HPV infection statuses in the first four rounds and subsequent (the fifth round) infection, infection type, and coinfection, and the influencing factors on different HPV infection statuses during the five rounds, respectively. Survival analysis was applied to explore the HPV clearance.

Results: A total of 20,817 females were included. Those experienced two or more HPV infections had the highest likelihood of being subsequent infection (Two or more vs. One: OR = 2.11, 95%CI: 1.61 ~ 2.76, P < 0.001). The risk of subsequent infection increases progressively (versus sustained infection-free) in one classification of HPV infection: a single transient infection (OR = 5.72, 95%CI: 4.66 ~ 7.01, P < 0.001), persistent infection (positivity in ≥ 2 consecutive rounds; OR = 10.78, 95%CI: 8.04 ~ 14.44, P < 0.001), reinfection (reversion to positivity after prior clearance; OR = 18.51, 95%CI: 11.58 ~ 29.57, P < 0.001), and lowest among those who cleared infection with no recurrence (OR = 2.99, 95%CI: 2.32 ~ 3.84, P < 0.001), highest among those with unsolved infection (OR = 23.21, 95%CI: 18.29 ~ 29.45, P < 0.001) or reinfection (OR = 18.79, 95%CI: 11.51 ~ 30.04, P < 0.001) in another classification. HPV infection status seemed not to associate with subsequent infection types and coinfection. Baseline age, at least one coinfections and HPV 16/18 infection may influence long-term HPV infection status. The median duration for HPV clearance is 1.98 years (95%CI:1.96 ~ 2.00), which significantly affected by baseline age (HR = 0.99, 95%CI: 0.98 ~ 0.99, P < 0.001) and history of coinfection (HR = 0.50, 95%CI: 0.80 ~ 1.02, P < 0.001).

Conclusions: When HPV vaccination coverage remains suboptimal, early identification of high-risk cervical cancer populations should prioritize characteristics including multiple/persistent/recurrence infection, coinfection, high-risk types infection, advanced age, and prolonged viral clearance time.

背景:HPV感染是宫颈癌的主要危险因素。HPV疫苗覆盖率仍然很低。早期识别具有某些特征的高危个体对于疫苗接种机会有限的人至关重要。目的:探讨不同HPV感染状态对继发感染、感染类型及合并感染的影响。并探讨了影响HPV长期感染状况及清除率的因素。方法:采用无锡市2013-2022年宫颈癌筛查数据。采用多变量和多项logistic回归模型分别评价前4轮与后续(第5轮)不同HPV感染状态、感染类型和合并感染之间的关系,以及5轮不同HPV感染状态的影响因素。生存分析用于探讨HPV清除。结果:共纳入20817名女性。2次或2次以上HPV感染者继发感染的可能性最高(2次或1次以上:or = 2.11, 95%CI: 1.61 ~ 2.76, P)结论:当HPV疫苗接种覆盖率仍不理想时,早期识别宫颈癌高危人群应优先考虑多发/持续/复发感染、合并感染、高危类型感染、高龄和病毒清除时间延长等特征。
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引用次数: 0
The role of significant others in the inadequate use of maternal healthcare among married women in Uganda: a secondary analysis of the 2016 demographic and health survey. 重要他人在乌干达已婚妇女孕产妇保健利用不足中的作用:对2016年人口与健康调查的二次分析。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-26 DOI: 10.1186/s41043-025-01151-3
Moses Festo Towongo, Olusegun S Ewemooje, Morrison Okezie Ogu

Background: Despite global efforts to improve maternal health outcomes, many regions, including Uganda, continue to face challenges in achieving optimal maternal healthcare utilization. This study aims to investigate how restricted autonomy in household decision-making by significant others affects inadequate use of maternal healthcare services among married women in Uganda. Inadequate use of maternal healthcare services refers to not meeting all four WHO-recommended standards for ANC timing, ANC visits, place of delivery, and PNC timing.

Methods: Secondary data from the latest 2016 Uganda Demographic and Health Survey (UDHS 2016) were used for this study. Data from 7906 married women of childbearing age were analyzed using a multilevel binary logistic regression approach.

Results: The inadequate use of maternal healthcare services was estimated to be 39.1%. The odds of inadequate use were 17% higher among women with moderate restricted autonomy in household decision-making by significant others compared to women with low restrictions [Adjusted Odds Ratio (AOR) = 1.17, 95% Confidence Interval (CI) = 1.02-1.34]. Inadequate use of MHCS decreases with an increase in the household wealth index. Women from the richest household [(AOR) = 0.52, 95% CI = 0.39,0.70] were less likely to report Inadequate use of maternal healthcare services compared to the poorest. Employed women were less likely [AOR = 0.73, 95% CI = 0.62-0.84] to report inadequate use of maternal healthcare services. Women who reside in the northern region of Uganda were significantly less likely [AOR = 0.72, 95% CI = 0.52-0.99] to report inadequate use of maternal healthcare services compared to those who reside in the central region.

Conclusion: The study concluded that the restricted autonomy in household decision-making by significant others plays a crucial role in the use of maternal healthcare services among married women in Uganda. Factors such as maternal age, household wealth index, employment status, and region of residence were also associated with inadequate use of maternal healthcare services. Therefore, to achieve Sustainable Development Goal (SDG) 3.1, the government and policymakers should engage significant others in maternal health programs, promote regional equity, female labor force participation, education, and autonomy in health decision-making.

背景:尽管全球努力改善孕产妇保健结果,但包括乌干达在内的许多地区在实现最佳孕产妇保健利用方面继续面临挑战。本研究旨在调查重要他人在家庭决策中受限制的自主权如何影响乌干达已婚妇女对孕产妇保健服务的不充分利用。孕产妇保健服务使用不足是指未达到世卫组织建议的四项标准,即产前分娩时机、产前就诊、分娩地点和产前分娩时机。方法:本研究使用最新的2016年乌干达人口与健康调查(UDHS 2016)的二手数据。对7906名已婚育龄妇女的数据进行多水平二元logistic回归分析。结果:孕产妇保健服务利用不足的比例为39.1%。在家庭决策中受到重要他人适度限制的妇女中,与受到低限制的妇女相比,不充分使用的几率高出17%[调整优势比(AOR) = 1.17, 95%可信区间(CI) = 1.02-1.34]。随着家庭财富指数的增加,MHCS使用不足的情况减少。与最贫困家庭相比,来自最富裕家庭的妇女[(AOR) = 0.52, 95% CI = 0.39,0.70]报告不充分利用孕产妇保健服务的可能性更小。就业妇女报告孕产妇保健服务使用不足的可能性较小[AOR = 0.73, 95% CI = 0.62-0.84]。与居住在中部地区的妇女相比,居住在乌干达北部地区的妇女报告未充分利用孕产妇保健服务的可能性显著降低[AOR = 0.72, 95% CI = 0.52-0.99]。结论:该研究得出结论,重要他人在家庭决策中的自主权受到限制,在乌干达已婚妇女使用孕产妇保健服务方面发挥了至关重要的作用。产妇年龄、家庭财富指数、就业状况和居住地区等因素也与产妇保健服务利用不足有关。因此,为了实现可持续发展目标3.1,政府和决策者应该让重要他人参与孕产妇保健计划,促进区域公平、女性劳动力参与、教育和健康决策自主权。
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引用次数: 0
Postnatal care service utilisation and associated factors among multiparous women in Buyamba County, Rakai District Uganda: a community-based cross-sectional study. 乌干达拉凯区布扬巴县多胎妇女的产后护理服务利用及其相关因素:一项基于社区的横断面研究。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-26 DOI: 10.1186/s41043-025-01192-8
Robinah Nakayima, Stephen Ssemujju, Newton Ekakoro

Background: Despite advancements in the use of maternity care services, certain nations in sub-Saharan Africa continue to record unacceptable rates of maternal and perinatal morbidity and mortality, particularly in the postnatal period. This study aimed to assess the level of postnatal care service utilisation and associated factors among multiparous women in Buyamba County, Rakai District, Uganda.

Method: A community-based cross-sectional study involving women who had two or more children was conducted in four sub-counties of Buyamba County. Study participants were recruited using a systematic sampling technique. A structured and pre-tested questionnaire was used to gather data. Descriptive, bivariate and modified poisson regressions were computed using STATA version 14. Statistical significance was considered at p < 0.05 and the strength of statistical association was assessed by prevalence ratios with 95% confidence intervals.

Result: Out of 321 women who participated in the study, (81.9%) were married, (30.8%) were aged 35-44 years, (71.0%) attended antenatal care (ANC) during their previous pregnancy, (94.7%) delivered normally, and (94.4%) utilised postnatal care (PNC) services of which (67.2%) received immunisation for the children, (26.2%) acquired family planning counseling and (70.3%) had four or more PNC visits. Attending antenatal care (aPR = 1.750; 95% CI: 1.029-2.981), being aware of PNC services (aPR = 1.380; 95% CI: 1.016-1.875), receiving PNC education (aPR = 1.421; 95% CI: 1.048-1.923), having a normal delivery (aPR = 1.538; 95% CI: 1.055-2.241), and residing within 5 km of a health facility (aPR = 1.282; 95% CI: 1.006-1.632) were significantly associated with a higher likelihood of utilising postnatal care services. In contrast, being younger in age (aPR = 0.511; 95% CI: 0.347-0.752) and having a husband without formal education (aPR = 0.622; 95% CI: 0.454-0.853) were significantly associated with a lower likelihood of postnatal care services utilisation.

Conclusion: The study identified several maternal, spousal, and accessibility factors influencing postnatal care utilisation. Enhancing maternal health education, improving facility access, involving partners, and strengthening antenatal counseling and community sensitisation can increase PNC utilisation and improve maternal and neonatal health outcomes.

背景:尽管在使用产妇保健服务方面取得了进展,但撒哈拉以南非洲的某些国家的产妇和围产期发病率和死亡率,特别是产后发病率和死亡率仍然高得令人无法接受。本研究旨在评估乌干达拉凯区布扬巴县产多胎妇女的产后护理服务利用水平及其相关因素。方法:在布扬巴县的四个副县开展了一项以社区为基础的横断面研究,涉及有两个或两个以上孩子的妇女。研究参与者是采用系统抽样技术招募的。使用结构化和预先测试的问卷来收集数据。使用STATA version 14计算描述性、双变量和修正泊松回归。结果:在参与研究的321名妇女中,(81.9%)已婚,(30.8%)年龄在35-44岁之间,(71.0%)在先前怀孕期间接受产前护理(ANC),(94.7%)正常分娩,(94.4%)利用产后护理(PNC)服务,其中(67.2%)接受儿童免疫接种,(26.2%)获得计划生育咨询,(70.3%)有四次或以上的PNC访问。参加产前护理(aPR = 1.750; 95% CI: 1.029-2.981)、了解PNC服务(aPR = 1.380; 95% CI: 1.016-1.875)、接受PNC教育(aPR = 1.421; 95% CI: 1.048-1.923)、正常分娩(aPR = 1.538; 95% CI: 1.055-2.241)、居住在卫生设施5公里范围内(aPR = 1.282; 95% CI: 1.006-1.632)与利用产后护理服务的可能性较高显著相关。相反,年龄较年轻(aPR = 0.511; 95% CI: 0.347-0.752)和丈夫未受过正规教育(aPR = 0.622; 95% CI: 0.454-0.853)与产后护理服务利用的可能性较低显著相关。结论:本研究确定了影响产后护理利用的几个母亲、配偶和可及性因素。加强孕产妇保健教育,改善设施使用,让合作伙伴参与,加强产前咨询和社区宣传,可以提高PNC的利用率,改善孕产妇和新生儿的健康结果。
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引用次数: 0
Association between ultra-processed foods intake and frailty risk in community-dwelling older adults. 在社区居住的老年人中,超加工食品摄入与衰弱风险之间的关系。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-25 DOI: 10.1186/s41043-025-01209-2
Jamal Hallajzadeh, Parasto Yousefi Tanha, Arian Azadnia, Alexei Wong, Sajjad Moradi

Aim: A community-based cross-sectional study was conducted to explore the association between Ultra-Processed Foods (UPFs) intake and the risk of frailty among community-dwelling older adults.

Methods: The current study was conducted on 368 community-dwelling older adults (with a mean age of 67.11 ± 6.21 years, of whom 55.2% were women) at health centers of Maragheh city in Iran. Body composition was measured by a body composition analyzer and physical activity by the short-form physical activity questionnaire. The UPFs intake were determined using NOVA classification, based on a self-administered 147-item semi-quantitative FFQ. Blood samples were derived for the evaluation of blood parameters. Raw and adjusted logistic regression models were used to examine the relationship between UPFs intake tertiles and the risk of frailty.

Results: Outcomes showed that the overall prevalence of frailty was 96 (26.1%). Results from the multivariable adjusted logistic regression model indicated that higher UPFs intake was significantly associated with higher odds of frailty (OR = 2.15, 95% CI: 1.13-4.09, P = 0.019). Subgroup analysis also indicated that among men, higher UPF intake was significantly related to higher odds of frailty (OR = 3.55, 95% CI: 1.20-10.51, P = 0.022), but not for women (P > 0.05). Additionally, the results revealed that higher UPF intake was significantly associated with the risk of exhaustion (OR = 3.97, 95% CI: 1.89-8.34, P < 0.001), especially among men (OR = 9.89, 95% CI: 3.10-31.60, P < 0.001), unlike women (P > 0.05). However, there were no significant associations between UPFs intake and other components of frailty, including the risk of weight loss, slowness, dominant hand grip strength and low physical activity.

Conclusions: The results highlighted that higher UPFs intake was significantly associated with the risk of frailty and exhaustion among community-dwelling older adults, especially for men. Future large-scale prospective and interventional studies are warranted to validate these associations and elucidate underlying biological mechanisms.

目的:一项以社区为基础的横断面研究旨在探讨超加工食品(upf)摄入量与社区老年人身体虚弱风险之间的关系。方法:本研究对伊朗Maragheh市卫生中心的368名社区老年人(平均年龄67.11±6.21岁,其中55.2%为女性)进行了研究。用身体成分分析仪测量身体成分,用简短的身体活动问卷测量身体活动。upf的摄入量是基于自我管理的147项半定量FFQ,使用NOVA分类来确定的。提取血液样本用于评估血液参数。使用原始和调整的逻辑回归模型来检验upf摄入量与虚弱风险之间的关系。结果:结果显示衰弱的总患病率为96(26.1%)。多变量调整logistic回归模型的结果表明,较高的upf摄入量与较高的虚弱几率显著相关(OR = 2.15, 95% CI: 1.13-4.09, P = 0.019)。亚组分析还表明,在男性中,较高的UPF摄入量与较高的虚弱几率显著相关(OR = 3.55, 95% CI: 1.20-10.51, P = 0.022),但对女性没有影响(P < 0.05)。此外,结果显示,较高的UPF摄入量与疲惫的风险显著相关(OR = 3.97, 95% CI: 1.89-8.34, P 0.05)。然而,摄入upf与身体虚弱的其他因素之间没有显著的关联,包括体重减轻的风险、行动迟缓、主要的手握力和低体力活动。结论:研究结果强调,在社区居住的老年人中,特别是男性,较高的upf摄入量与虚弱和疲惫的风险显著相关。未来有必要进行大规模的前瞻性和干预性研究,以验证这些关联并阐明潜在的生物学机制。
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引用次数: 0
Under the bidirectional screening policy, impact of diabetes mellitus on patient and diagnosis delays of pulmonary tuberculosis patients in Ningxia, China: a propensity score analysis. 双向筛查政策下,糖尿病对宁夏地区肺结核患者发病及诊断延误的影响:倾向评分分析
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-24 DOI: 10.1186/s41043-025-01195-5
Ying Zhang, Juan Lei, Wenxuan Li, Ye Li, Libo Liang, Xiaomei Tian, Wei Liu, Zehui Li, Siqi Wu, Longjia Wu, Xiaolin Wei, Hui Yin
<p><strong>Background: </strong>Although the policy of screening tuberculosis (TB) in individuals with diabetes mellitus (DM) was suggested, the coexistence of TB and DM is rapidly increasing in China, hindering the country's TB elimination efforts. The delay in TB consultation and diagnosis poses a challenge for DM-TB patients. However, the impact of DM on TB is not fully understood. Our study aimed to evaluate patient and diagnosis delays in pulmonary tuberculosis (PTB) patients in Ningxia, China, investigate the relationship between DM comorbidity and delays, and provide recommendations for improving the implementation of TB prevention and control strategies.</p><p><strong>Methods: </strong>We examined all PTB patients with DM registered in the Chinese TB Information Management System (TBIMS) in the Ningxia region from 2016 to 2019. Patient delay was defined as > 20 days from symptom onset to first medical consultation, and diagnosis delay as > 1 day from first consultation to diagnosis, both measured in days. In our study, possible covariates were screened based on relevant literatures, then mediating variables were excluded, and finally covariates were screened by univariate analysis. Propensity score matching (PSM) was conducted (1:1 nearest matching with a caliper of 0.25 standard deviation (SD) of the propensity score (PS), without replacement) using covariates including sex, age, ethnicity, household registration, occupation, type of hospital for initial PTB diagnosis, level of hospital for initial PTB diagnosis, X-ray, the presence of other types of TB, and patient source. Logistic regression was then employed to assess the impact of DM on patient and diagnosis delays. Additionally, we conducted sensitivity analyses, exploring different ratios and caliper sizes, and mahalanobis distance matching. To address the potential for residual confounding by age, we conducted a further sensitivity analysis using age as a continuous variable in the PS model.</p><p><strong>Results: </strong>Out of 9,625 PTB patients registered in TBIMS, 260 (2.7%) were also diagnosed with DM. In the unadjusted analysis, there was no difference in the median duration of patient delay between NDM-PTB and DM-PTB patients (20 days vs. 22 days, P > 0.05), while the median diagnosis delay was significantly longer in DM-PTB patients (1 day vs. 3 days, P < 0.05). However, after PSM to control for confounders, regression analysis indicated that DM was associated with a higher likelihood of experiencing patient delay [odds ratio (OR) = 1.85; 95% confidence interval (CI) = 1.30-2.64], but not with diagnosis delay (OR = 1.29; 95% CI = 0.89-1.87). In conclusion, after balancing baseline characteristics, DM was a risk factor for patient delay in PTB patients, but not for diagnosis delay.</p><p><strong>Conclusions: </strong>Our study revealed that DM only exacerbated patient delay and ultimately had no significant effect on diagnosis delay. This suggests that screening for TB in
背景:虽然建议对糖尿病患者进行结核病筛查,但在中国,结核病和糖尿病共存的情况正在迅速增加,阻碍了国家消除结核病的努力。结核病咨询和诊断的延误对DM-TB患者构成了挑战。然而,DM对结核病的影响尚不完全清楚。本研究旨在评估宁夏肺结核(PTB)患者的患者和诊断延误情况,探讨糖尿病合并症与延误之间的关系,并为改善结核病预防和控制策略的实施提供建议。方法:对宁夏地区2016 - 2019年在中国结核病信息管理系统(tims)中登记的所有PTB合并DM患者进行调查。患者延迟定义为从症状出现到首次就诊的bbb20天,诊断延迟定义为从首次就诊到诊断的> 1天,均以天为单位。在我们的研究中,首先根据相关文献筛选可能的协变量,然后排除中介变量,最后通过单因素分析筛选协变量。使用协变量包括性别、年龄、种族、户籍、职业、首次诊断肺结核的医院类型、首次诊断肺结核的医院级别、x射线、是否存在其他类型结核病和患者来源,进行倾向评分匹配(1:1最接近匹配,不更换倾向评分0.25标准差(SD)的卡尺)。然后采用Logistic回归来评估糖尿病对患者和诊断延迟的影响。此外,我们还进行了敏感性分析,探索了不同比例和卡尺尺寸以及马氏比目鱼距离匹配。为了解决年龄可能造成的残留混淆,我们在PS模型中使用年龄作为连续变量进行了进一步的敏感性分析。结果:在tims中登记的9625例PTB患者中,260例(2.7%)同时诊断为DM。在未经调整的分析中,NDM-PTB患者和DM-PTB患者的中位诊断延迟时间没有差异(20天对22天,P >.05),而DM-PTB患者的中位诊断延迟时间明显更长(1天对3天,P结论:我们的研究显示DM只加剧了患者的延迟,最终对诊断延迟没有显著影响。这表明对糖尿病患者进行结核病筛查可以减少诊断延误。因此,加强社区对糖尿病患者的结核病健康教育至关重要。推广结核病综合管理模式,提高基层医疗机构医生对DM-PTB合并症、鉴别诊断和诊断能力的认识,有效预防和控制结核病。
{"title":"Under the bidirectional screening policy, impact of diabetes mellitus on patient and diagnosis delays of pulmonary tuberculosis patients in Ningxia, China: a propensity score analysis.","authors":"Ying Zhang, Juan Lei, Wenxuan Li, Ye Li, Libo Liang, Xiaomei Tian, Wei Liu, Zehui Li, Siqi Wu, Longjia Wu, Xiaolin Wei, Hui Yin","doi":"10.1186/s41043-025-01195-5","DOIUrl":"10.1186/s41043-025-01195-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Although the policy of screening tuberculosis (TB) in individuals with diabetes mellitus (DM) was suggested, the coexistence of TB and DM is rapidly increasing in China, hindering the country's TB elimination efforts. The delay in TB consultation and diagnosis poses a challenge for DM-TB patients. However, the impact of DM on TB is not fully understood. Our study aimed to evaluate patient and diagnosis delays in pulmonary tuberculosis (PTB) patients in Ningxia, China, investigate the relationship between DM comorbidity and delays, and provide recommendations for improving the implementation of TB prevention and control strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We examined all PTB patients with DM registered in the Chinese TB Information Management System (TBIMS) in the Ningxia region from 2016 to 2019. Patient delay was defined as &gt; 20 days from symptom onset to first medical consultation, and diagnosis delay as &gt; 1 day from first consultation to diagnosis, both measured in days. In our study, possible covariates were screened based on relevant literatures, then mediating variables were excluded, and finally covariates were screened by univariate analysis. Propensity score matching (PSM) was conducted (1:1 nearest matching with a caliper of 0.25 standard deviation (SD) of the propensity score (PS), without replacement) using covariates including sex, age, ethnicity, household registration, occupation, type of hospital for initial PTB diagnosis, level of hospital for initial PTB diagnosis, X-ray, the presence of other types of TB, and patient source. Logistic regression was then employed to assess the impact of DM on patient and diagnosis delays. Additionally, we conducted sensitivity analyses, exploring different ratios and caliper sizes, and mahalanobis distance matching. To address the potential for residual confounding by age, we conducted a further sensitivity analysis using age as a continuous variable in the PS model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Out of 9,625 PTB patients registered in TBIMS, 260 (2.7%) were also diagnosed with DM. In the unadjusted analysis, there was no difference in the median duration of patient delay between NDM-PTB and DM-PTB patients (20 days vs. 22 days, P &gt; 0.05), while the median diagnosis delay was significantly longer in DM-PTB patients (1 day vs. 3 days, P &lt; 0.05). However, after PSM to control for confounders, regression analysis indicated that DM was associated with a higher likelihood of experiencing patient delay [odds ratio (OR) = 1.85; 95% confidence interval (CI) = 1.30-2.64], but not with diagnosis delay (OR = 1.29; 95% CI = 0.89-1.87). In conclusion, after balancing baseline characteristics, DM was a risk factor for patient delay in PTB patients, but not for diagnosis delay.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our study revealed that DM only exacerbated patient delay and ultimately had no significant effect on diagnosis delay. This suggests that screening for TB in ","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":" ","pages":"28"},"PeriodicalIF":2.8,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biofortification as a sustainable strategy to address micronutrient malnutrition in South Asia. 生物强化作为解决南亚微量营养素营养不良的可持续战略。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-24 DOI: 10.1186/s41043-025-01108-6
Aneesha VijayaKumar, Irshaan Syed, Harshavardhan Dhulipalla, Payel Ghosh, Laxmikarthika V Srinivasan, Faraz Ahmad, Sandeep Singh Rana, Vipin Singh

Malnutrition is a significant public health concern affecting many populations, particularly in developing countries such as India and its neighboring economies. It can lead to adverse health outcomes, including stunted growth, impaired cognition, and increased susceptibility to disease. This review attempts to summarize the problems associated with malnutrition in different age groups in India and its neighboring countries, and the accompanying factors contributing to it. We also summarize the different biofortification techniques, which, when appropriately implemented, can alleviate these problems and potentially increase the availability and accessibility of crucial micronutrients such as vitamins and minerals in the diets of vulnerable populations. Government schemes and policies for scaling up biofortification interventions, as well as increasing public awareness and acceptance of biofortified crops, have also been delineated. In conclusion, while significant challenges remain, biofortification represents a promising approach for combating malnutrition, although further research and evaluations are needed to realize its potential impact fully.

营养不良是影响许多人口的重大公共卫生问题,特别是在印度等发展中国家及其邻近经济体。它可能导致不良的健康结果,包括发育迟缓、认知受损和对疾病的易感性增加。本文试图总结印度及其邻国不同年龄组营养不良的相关问题,以及导致营养不良的相关因素。我们还总结了不同的生物强化技术,这些技术在适当实施时可以缓解这些问题,并有可能增加弱势群体饮食中维生素和矿物质等关键微量营养素的可得性和可及性。还概述了政府扩大生物强化干预措施的计划和政策,以及提高公众对生物强化作物的认识和接受程度。总之,尽管仍然存在重大挑战,但生物强化是对抗营养不良的一种有希望的方法,尽管需要进一步的研究和评估来充分认识其潜在影响。
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引用次数: 0
The role of multivitamin and mineral supplements in supporting health and well-being: a retrospective cross-sectional study in Taiwan. 复合维生素和矿物质补充剂在支持健康和福祉中的作用:台湾的回顾性横断面研究。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-23 DOI: 10.1186/s41043-025-01164-y
Vandana Garg, Joseph Lin, Aida Gadzhieva-Moore, Shi Mun Yee, Abhijeet Dhiman, Richa Kumari, Sheryl S L Tan

Background: Multivitamin and mineral (MVM) supplements have been shown to provide various health benefits, including enhanced energy, skin health, metabolism, and immune function. This study explored the impact of MVM supplements based on users' experience in Taiwan.

Methods: This retrospective, real-world, cross-sectional study included 400 respondents, aged 35-60 years, residing in Taiwan. Data were collected via an online survey. Respondents self-reported perceived benefits across six youthful vitality benefits: energy, metabolism, sleep, mental alertness, skin health and complexion, and spirit. Additional assessments covered perceived immunity, general health, quality-of-life (QoL), well-being, user attitude and perception. Subgroup analyses was performed post hoc based on gender (male vs. female), age (< 50 vs. ≥50 years) and frequency of use (daily vs. occasional) to explore potential subgroup differences in perceived benefits.

Results: A total of 93% of users agreed that MVM supplements support at least one out of six youthful vitality benefits. Users reported several perceived benefits: energy support (59.00%), improved metabolism (59.75%), improved complexion (53.25%), normal immune functioning (66.25%), confident in maintaining overall health (63.25%). Satisfaction levels were notably high, with 74.50% expressing satisfaction with product use, 72.50% trusting the product, and 79.00% showed willingness to repurchase. Subgroup analyses suggested that males, daily users, and users aged ≥ 50 years experienced more favorable outcomes across several parameters as compared to their respective counterparts.

Conclusion: This study provides real-world evidence that MVM supplements are widely perceived to support youthful vitality, immunity, general health, and QoL. These user-reported outcomes complement existing clinical research by highlighting benefits experienced in everyday settings, especially among daily users and those aged 50 and above. The high satisfaction and trust levels observed further reinforce the relevance of MVM supplements as a self-care strategy. By bridging the gap between controlled trials and consumer experience, this study adds valuable context to the science and recommendation of micronutrient supplementation.

背景:多种维生素和矿物质(MVM)补充剂已被证明具有多种健康益处,包括增强能量、皮肤健康、新陈代谢和免疫功能。本研究以台湾使用者经验为基础,探讨MVM补充品的影响。方法:本研究为回顾性横断面研究,调查对象为400名台湾居民,年龄35-60岁。数据是通过在线调查收集的。受访者自我报告了六种年轻活力的好处:能量、新陈代谢、睡眠、精神警觉、皮肤健康和肤色,以及精神。其他评估包括感知免疫力、一般健康、生活质量、福祉、用户态度和感知。亚组分析是基于性别(男性vs.女性),年龄(结果:总共93%的用户同意MVM补充剂至少支持六种年轻活力益处中的一种)。用户报告了几个感知到的益处:能量支持(59.00%),改善新陈代谢(59.75%),改善肤色(53.25%),正常免疫功能(66.25%),保持整体健康的信心(63.25%)。满意度非常高,74.50%的人对产品的使用表示满意,72.50%的人对产品表示信任,79.00%的人表示愿意再次购买。亚组分析表明,男性、每日服用者和年龄≥50岁的服用者在几个参数上都比各自的对应者有更有利的结果。结论:本研究提供了真实世界的证据,证明MVM补充剂被广泛认为可以支持年轻活力、免疫力、整体健康和生活质量。这些用户报告的结果通过强调在日常环境中体验到的益处来补充现有的临床研究,特别是在日常使用者和50岁及以上的人群中。观察到的高满意度和信任度进一步加强了MVM补充剂作为一种自我保健策略的相关性。通过弥合对照试验和消费者经验之间的差距,本研究为微量营养素补充的科学和建议提供了有价值的背景。
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引用次数: 0
The relationship between sustainable dietary behaviors, sustainable food literacy, healthy life awareness, and social media addiction in adults: a cross-sectional study in Türkiye. 成人可持续饮食行为、可持续食物素养、健康生活意识和社交媒体成瘾之间的关系:一项来自<s:1> rkiye的横断面研究。
IF 2.8 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2025-12-23 DOI: 10.1186/s41043-025-01190-w
Fatma Elif Eroğlu, Büşra Açıkalın Göktürk, Zeynep Begüm Kalyoncu Atasoy, Özge Mengi Çelik

Background: Sustainable food literacy, healthy life awareness, and adherence to sustainable dietary models such as the Mediterranean diet are critical for promoting both public health and environmental well-being. While sociodemographic influences have been examined in previous research, the potential role of social media addiction as a behavioral factor in shaping sustainable dietary practices remains underexplored.

Objectives: This study aimed to investigate how sustainable food literacy, healthy life awareness, and social media addiction relate to Mediterranean diet adherence and nutritional sustainability in adults, while also accounting for key sociodemographic characteristics.

Methods: This cross-sectional online study included 2,263 adults (60.5% female; mean age, 29.4 ± 11.7 years; mean BMI, 24.54 ± 6.8 kg/m²). Data were collected using the Sustainable Food Literacy Scale (SFLS), Social Media Addiction Scale (SMAS), Adherence to the Mediterranean Diet and Nutritional Sustainability Questionnaire Turkish Version (MedQ-Sus-Tr), and Healthy Life Awareness Scale (HLAS). Pearson correlation and multiple linear regression analyses were performed.

Results: Based on the MedQ-Sus-Tr, 91.0% of participants were classified as having low adherence to the Mediterranean diet, and 70.1% were classified as having low nutritional sustainability. Mediterranean diet adherence showed the strongest correlation with nutritional sustainability (r = 0.728, p < 0.001). Predictors of Mediterranean diet adherence included marital status, income, SFLS, and HLAS (R² = 0.365), while nutritional sustainability was predicted by marital status, income, SFLS, and HLAS (R² = 0.301). SFLS was associated with sex, education level, marital status, income, social media addiction, HLAS, Mediterranean diet adherence, and nutritional sustainability (R² = 0.704). HLAS was predicted by sex, age, SFLS, social media addiction, Mediterranean diet adherence, and nutritional sustainability (R² = 0.696).

Conclusions: Our findings highlight that higher sustainable food literacy and healthy life awareness significantly predict greater adherence to the Mediterranean diet and improved nutritional sustainability, regardless of sociodemographic characteristics. Social media addiction was positively associated with both literacy and awareness, though it did not directly predict dietary adherence or sustainability. These results suggest that while social media use may enhance exposure to nutrition-related information, its impact on actual dietary behaviors is less direct. Targeted interventions should therefore leverage the informational potential of digital platforms, while also fostering translation of awareness into healthier and more sustainable eating practices.

背景:可持续食品素养、健康生活意识和坚持地中海饮食等可持续饮食模式对于促进公众健康和环境福祉至关重要。虽然在之前的研究中已经研究了社会人口统计学的影响,但社交媒体成瘾作为一种行为因素在塑造可持续饮食习惯方面的潜在作用仍未得到充分探索。目的:本研究旨在调查可持续食品素养、健康生活意识和社交媒体成瘾与成人地中海饮食依从性和营养可持续性之间的关系,同时也考虑了关键的社会人口统计学特征。方法:该横断面在线研究包括2263名成年人(60.5%为女性,平均年龄29.4±11.7岁,平均BMI为24.54±6.8 kg/m²)。使用可持续食物素养量表(SFLS)、社交媒体成瘾量表(SMAS)、地中海饮食依从性和营养可持续性问卷土耳其版(medq - su - tr)和健康生活意识量表(HLAS)收集数据。进行Pearson相关和多元线性回归分析。结果:根据MedQ-Sus-Tr, 91.0%的参与者被归类为地中海饮食依从性低,70.1%被归类为营养可持续性低。结论:我们的研究结果强调,无论社会人口特征如何,更高的可持续食品素养和健康生活意识显著地预示着更强的地中海饮食依从性和更好的营养可持续性。社交媒体成瘾与识字和意识呈正相关,尽管它并不能直接预测饮食的坚持或可持续性。这些结果表明,虽然社交媒体的使用可能会增加对营养相关信息的接触,但它对实际饮食行为的影响并不直接。因此,有针对性的干预措施应利用数字平台的信息潜力,同时促进将意识转化为更健康和更可持续的饮食习惯。
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引用次数: 0
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