Background: Cancer treatments can affect nutritional status by impairing a person's ability to consume an adequate amount of food and absorb nutrients, which are important factors in reducing health-related quality of life (HRQoL). Consequently, this research aimed to investigate the correlation between the likelihood of malnutrition and quality of life among individuals with solid cancer in Palestine. In addition, factors that are linked to the HRQoL of these patients should be identified.
Methods: A cross-sectional study was conducted at two major cancer referral hospitals in the northern West Bank, Al-Watani Government Hospital and An-Najah National University Hospital in Nablus, between July 31, 2022, and February 28, 2023. The five-level EuroHRQOL five-dimensional instrument (EQ-5D-5 L) was used to assess HRQOL. Nutritional status was assessed via the Nutrition Risk Screening 2002 (NRS-2002) tool. Multiple linear regression analysis was performed to determine the most important variables related to HRQOL.
Results: A total of 304 patients with solid tumors were included in this study. The most common cancers among these patients were breast (40.5%) and colorectal (26%) cancers. A moderate negative correlation was observed between the EQ-5D-5 L score and the NRS-2002 score (r = - 0.207; 95% CI: - 0.26 to - 0.15; p < 0.001). Regression analysis revealed that working patients (β = 0.152; 95% CI: 0.045 to 0.255; p = 0.005), those with fewer disease-related complications related to dietary intake (β = - 0.311; 95% CI: - 0.415 to - 0.208; p < 0.001), and individuals with lower NRS scores (β = - 0.135; 95% CI: - 0.243 to - 0.027; p = 0.015) were independently associated with higher HRQoL.
Conclusions: Our results suggest that lower nutritional risk, employment, and fewer disease complications are associated with better HRQoL among cancer patients, underscoring the importance of early nutritional assessment and patient-centred care, especially in low-resource settings.
Background: Sarcopenia is a generalized and progressive loss of skeletal muscle mass and function, which is associated with various adverse health outcomes, such as fractures, impaired mobility, and increased mortality. Bioactive peptides (BPs) are absorbable protein fragments that remain bioaccessible after digestion. In the present study, we investigated whether the intake of BPs derived from dairy products could reduce the risk of sarcopenia by analyzing the dietary habits of elderly individuals with sarcopenia.
Methods: This case-control study used data collected from a population-based cross-sectional study conducted at healthcare centers in Shiraz, Iran. A total of 80 individuals diagnosed with sarcopenia and 80 control subjects without sarcopenia were selected. Sarcopenia was defined according to the diagnostic criteria established by the Asian Working Group for Sarcopenia. Dietary intake over the previous year was assessed using a semi-quantitative food frequency questionnaire consisting of 168 items. The amount of digestion-resistant BPs in dairy products was estimated by multiplying the grams of dairy consumed by the peptide content present in these products. The association between the intake of digestion-resistant BPs from dairy products and the risk of sarcopenia was evaluated using logistic regression analysis.
Results: In the unadjusted analysis, participants with higher total peptide consumption had markedly reduced odds of sarcopenia compared with those in the lower-intake reference group (odds ratio [OR ]= 0.163, 95% confidence interval [CI]: 0.082-0.323, P < 0.001). After adjusting for potential confounders, the inverse association between total peptide intake and the odds of sarcopenia remained statistically significant. Individuals with greater total peptide intake showed substantially lower odds of sarcopenia than those in the low-intake reference group (OR = 0.336, 95% CI: 0.149-0.897, P = 0.028).
Conclusions: In summary, our findings suggest that BPs derived from dairy products are inversely associated with the risk of sarcopenia. Given the cross-sectional and retrospective design, causality cannot be established, and further prospective or interventional studies are needed to confirm these associations.
Introduction: Social support in pregnancy and postpartum is important for optimizing maternal and infant health. Group prenatal care offers the opportunity for in-person social support yet does not extend into the postpartum period. Mobile social support models may further meet the needs of pregnant individuals and partners during pregnancy and into the postpartum period. However, the use and utility of mobile social support for pregnant people and their partners in the context of group prenatal care and beyond has not been studied. Assessing Centering patients' utilization of existing social media platforms can inform programmatic development.
Methods: We conducted a retrospective cross-sectional study among recent participants of UCSF's Centering Pregnancy® program and their partners. Study participants were recruited through UCSF's electronic health record system or direct email and partners were recruited through referral from participants. Online surveys sought to understand participant perspectives on mobile groups, educational and social support needs, and recommendations.
Results: Participants gave birth between 2018 and 2021 (68%), were college-educated (97.3%), and regularly accessed social media (> 75% across platforms). Most participants engaged in Centering Pregnancy® online communications outside of formal activities (79% during pregnancy, 74% postpartum) for social support (78.1%) and knowledge sharing (65.2%). Most posted content monthly (54.6%) but read content more frequently (48.0% at least weekly). Communication frequency and topics changed with the COVID-19 pandemic. Respondents wanted more information on infant sleep (42.6%), maternal recovery/health (38.7%), breastfeeding/formula feeding (37.4%), newborn health and care (34.2%), and child development (27.1%). Social group engagement was higher for individuals reporting depressive or anxiety symptoms during pregnancy and postpartum.
Discussion: The findings confirm the importance of social support, especially postpartum, for health, how mobile support groups can impact these outcomes, and needs and areas of improvement for group prenatal care. Integration of a social media support component to the evolving post-COVID Centering Pregnancy® model may be an important addition to improve participating parent wellbeing.
Background: Renal dysfunction poses a significant global health burden, with occupational hazards in the petroleum industry potentially contributing to its development. This cohort study aimed to evaluate the impact of four occupational hazards-high temperature, noise, benzene compounds, and shift work-on renal dysfunction in a cohort of oil workers.
Methods: A prospective cohort study was conducted using data from the "Beijing-Tianjin-Hebei Occupational Population Health Effects Cohort." A total of 2,292 petroleum workers without baseline renal dysfunction were followed from 2017 to 2021. Renal dysfunction was defined as an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m2. Occupational exposures were assessed using national standards and weighted shift index (WSI) for shift work. Cox regression models, restricted cubic spline analysis, and interaction assessments were employed to analyze associations.
Results: Over four years, 24.52% of workers developed renal dysfunction. Multivariate Cox regression revealed significant risks for workers exposed to high temperature (P = 0.003, HR = 1.33, 95% CI:1.10-1.61), noise (P = 0.001, HR = 1.43, 1.18-1.72), benzene compounds (P = 0.001, HR = 1.70, 1.42-2.05), and high-intensity shift work (WSI > 1022.75; P = 0.001, HR = 1.96, 1.60-2.40). Additive interactions were observed between high-intensity shift work and high temperature (RERI = 1.89), noise (RERI = 1.40), and benzene compounds (RERI = 3.07). Moderate shift work intensity showed a protective effect.
Conclusions: Exposure to noise, benzene compounds, and high-intensity shift work independently increased renal dysfunction risk among petroleum workers. An association was also observed for high-temperature exposure, and interactions between these hazards amplified risks, highlighting the need for targeted interventions to mitigate occupational exposures.
Tirzepatide, a novel dual GIP and GLP-1 receptor agonist, has demonstrated robust efficacy in clinical trials; however, discontinuation rates due to gastrointestinal adverse events have been reported at 6-10% in Western populations. In contrast, our real-world study of 219 Japanese patients revealed a markedly lower discontinuation rate of approximately 1.3%. Dietary questionnaires indicated that patients experienced reduced appetite for high-fat and high-calorie foods while maintaining consumption of low-carbohydrate traditional Japanese foods such as fish and meat, which may have contributed to the low discontinuation rate.
Background: Self-efficacy is a well-known concept often referred to as the belief in the ability to perform in different situations. The concept of self-efficacy is particularly relevant during adolescence, as it serves as a self-regulatory mechanism through which adolescents can be motivated to change their behavior by significant others, such as parents. However, there is little research evidence on how parental factors are associated with adolescents' self-efficacy. Hence, this current paper aimed to describe parental self-efficacy, health-related quality of life (HRQOL), stress, and educational level and explore associations between the participating parent's self-efficacy, HRQOL, stress, and educational level on adolescents' self-efficacy stratified by gender.
Methods: A cross-sectional study was performed among 508 Norwegian adolescent-parent dyads. Adolescents were 13-15 years old and completed an electronic survey during school hours with teacher and researcher present, whereas the participating parent completed the survey at home. The Survey comprised of a test battery of questionnaires, including sociodemographic data, self-efficacy for both adolescents and parents, and the parental factors: stress, HRQOL, and educational level. Separate multivariable regressions were conducted for the participating parent using STATA software.
Results: Descriptive analyses revealed a self-efficacy score of (mean/standard deviation (SD), 32.9 (4.0) vs. 34.1 (4.3)), HRQOL (mean/SD, PCS 51.1 (9.5) vs. 53.3 (7.0), MCS 51.9 (8.2) vs. 54.1 (7.2)) and stress (mean/SD, 0.28 (0.24) vs. 0.25 (0.15) among mothers and fathers respectively. Half of the mothers (506%) and 46.1% of the fathers reported ≥ 16 years of education. Multivariable regressions revealed all nonsignificant associations of all parental study variables on adolescents' self-efficacy (all p > 0.05).
Conclusions: In this study, the parental factors examined were not associated with adolescents' self-efficacy. These findings highlight the need for further observational and longitudinal studies with larger samples to better understand how parental factors influence adolescents' self-efficacy.
Background: Products harmful to health encompass a wide range of goods, including tobacco, high-fat, high-salt, and high-sugar foods, alcoholic beverages, addictive substances, unlicensed food supplements, and certain cosmetic products. This study aimed to assess the extent of inequality in the consumption of such health-harmful products among Iranian households.
Methods: This secondary analysis utilized data from Iran's 2019 Households Income and Expenditure Survey, comprising a representative sample of 38,328 households. Expenditures on harmful products were identified following guidelines from Iran's Ministry of Health. The Gini coefficient measured inequality in absolute household expenditure, while the concentration index assessed inequalities in expenditure on harmful products across households with varying socio-economic status, using household income, education level, and occupation of the household head as separate proxies.
Results: The Gini coefficients indicated significant inequality in both absolute and relative household expenditures across all categories of harmful products. Concentration indices for subcategories of harmful products remained below 0.2 across income, education, and occupation groups, with income-related inequalities slightly exceeding those related to education or occupation.
Conclusion: Expenditures on harmful products exhibit notable but not extreme inequality across different socio-economic groups. Policymakers should consider all income, education, and occupation strata when designing interventions to reduce spending on unhealthy products, with particular focus on lower-income households.
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