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Impact of Glucagon-Like Peptide-1 Receptor Agonists on Retained Gastric Contents During Esophagogastroduodenoscopy: A Propensity Score-Matched Study 胰高血糖素样肽-1受体激动剂对食管胃十二指肠镜检查中保留胃内容物的影响:一项倾向评分匹配研究。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-08-17 DOI: 10.1111/den.70016
Hiroyuki Hisada, Yosuke Tsuji, Dai Kubota, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Seiichi Yakabi, Chihiro Takeuchi, Naomi Kakushima, Nobutake Yamamichi, Mitsuhiro Fujishiro

Objectives

Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are commonly used for diabetes management and are associated with delayed gastric emptying, raising concerns about an increased risk of retained gastric contents (RGC) during esophagogastroduodenoscopy (EGD). While this association has been investigated in Western populations, limited data are available for Asian populations.

Methods

We conducted a retrospective study involving 1324 patients with diabetes who underwent screening EGD between January 2020 and December 2023. Propensity score matching was used to compare 148 patients receiving GLP-1 RA with 148 patients not receiving GLP-1 RA. We evaluated the relationship between GLP-1 RA use and the incidence of RGC during EGD.

Results

RGC occurred more frequently in the GLP-1 RA group compared to the non-GLP-1 RA group, both before (12.0% vs. 3.7%, p < 0.001) and after matching (12.2% vs. 3.4%, p = 0.009). The association between GLP-1 RA use and RGC remained consistent in subgroup analyses, including patients without a history of peptic ulcer scars or endoscopic treatment as well as those not receiving DPP-4 inhibitors. Repeated EGD procedures were more frequent in the GLP-1 RA group; however, no cases of aspiration pneumonia after EGD were observed.

Conclusions

The use of GLP-1 RA in patients with diabetes significantly increases the risk of RGC during EGD in Asian populations. Implementing precautions, such as recommending a liquid diet the day before EGD, may help mitigate this risk in clinical practice.

目的:胰高血糖素样肽-1受体激动剂(GLP-1 RA)通常用于糖尿病治疗,并与胃排空延迟有关,引起了对食管胃十二指肠镜检查(EGD)期间胃内容物残留(RGC)风险增加的担忧。虽然这种关联已经在西方人群中进行了调查,但在亚洲人群中可获得的数据有限。方法:我们进行了一项回顾性研究,纳入了2020年1月至2023年12月期间接受EGD筛查的1324例糖尿病患者。倾向评分匹配用于比较148例接受GLP-1 RA的患者和148例未接受GLP-1 RA的患者。我们评估了GLP-1 RA的使用与EGD期间RGC发生率之间的关系。结果:与非GLP-1 RA组相比,GLP-1 RA组的RGC发生率更高(12.0% vs. 3.7%)。结论:糖尿病患者在EGD期间使用GLP-1 RA显著增加了RGC的风险。在临床实践中,采取预防措施,如在EGD前一天推荐流质饮食,可能有助于减轻这种风险。
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引用次数: 0
Stent Retrieval Technique Using a Basket Catheter With a Rotation Function for Retrieval of Thread-Attached Stent 带旋转功能的篮状导管用于螺纹支架的取出技术。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-08-08 DOI: 10.1111/den.70013
Masafumi Watanabe, Kosuke Okuwaki, Chika Kusano

Inside stents [1, 2] placed above the papilla for upper bile duct strictures were useful [3] and equipped with a retrieval thread for stent removal (Figure 1). However, when the distal flap becomes lodged in a biliary branch, stent removal is challenging due to the weak grip of the forceps and slippage of the retrieval thread. We report a useful technique for easy stent retrieval by rotating an 8-wire basket catheter (RASEN2, Kaneka Medix Corporation, Osaka, Japan) and entangling the retrieval thread to the basket catheter for a firm grasp.

The patient was a 76-year-old man with intrahepatic cholangiocarcinoma who had two stents placed 4 months prior to biliary obstruction. Endoscopic retrograde cholangiopancreatography was performed for the stent exchange. The first stent was easily retrieved by grasping the retrieval thread using forceps; however, the distal flap of the second stent was caught on the biliary duct branch, making retrieval difficult. Attempts to grasp the stent using a snare and forceps were unsuccessful. An 8-wire basket catheter was then used and deployed alongside the retrieval thread. The guide wire was placed inside the catheter to prevent tangling. As the catheter was advanced, the retrieval thread was pulled into the side of the stent. While rotating the catheter, we deliberately pressed it against the bile duct to change its angle. The catheter and retrieval threads were easily tangled, allowing the stent to integrate securely and rotate. The retrieval thread was firmly grasped, the flap was released, and the stent was successfully retrieved (Figure 2).

In conclusion, rotating a basket catheter and entangling the retrieval thread make it possible to easily retrieve stents, even in challenging cases, as the retrieval thread and catheter become integrated.

Masafumi Watanabe designed the study, the main conceptual ideas, and the outline. Masafumi Watanabe edited the video and wrote the manuscript with support from Kosuke Okuwaki. Chika Kusano supervised the project. All the authors discussed the results and commented on the manuscript.

The authors have nothing to report.

The authors declare no conflicts of interest.

对于上胆管狭窄,将内支架置于乳头上方[1,2]是有用的,并配有取出支架的取出线(图1)。然而,当远端皮瓣卡在胆道分支时,由于钳的握力弱和取物线的滑脱,支架移除是具有挑战性的。我们报告了一种有用的技术,通过旋转一根8丝篮式导管(RASEN2, Kaneka Medix Corporation, Osaka, Japan)并将取物线缠在篮式导管上以牢牢抓住支架。患者是一名患有肝内胆管癌的76岁男性,在胆道梗阻前4个月放置了两个支架。内镜逆行胆管造影用于支架置换。用镊子夹紧取物线即可轻松取出第一个支架;然而,第二个支架的远端皮瓣夹在胆管分支上,使取出困难。试图用圈套和钳子抓住支架是不成功的。然后使用8丝篮导管,并将其与检索线一起部署。导丝放置在导管内以防止缠结。随着导管的推进,取出线被拉入支架的侧面。在旋转导管时,我们故意将其压在胆管上以改变其角度。导管和回收线很容易缠结,允许支架安全整合和旋转。牢牢抓住取物线,松开皮瓣,成功取出支架(图2)。综上所述,旋转篮状导管并缠绕检索线可以轻松检索支架,即使在具有挑战性的病例中,因为检索线和导管已经整合在一起。Masafumi Watanabe设计了该研究,主要概念思想和大纲。渡边雅文编辑了视频,并在奥崎浩介的支持下撰写了手稿。Chika Kusano监督了这个项目。所有作者都讨论了结果并对稿件进行了评论。作者没有什么可报告的。作者声明无利益冲突。
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引用次数: 0
Balloon Enteroscopy-Assisted ERCP Versus Endoscopic Ultrasound-Guided Biliary Drainage for Unresectable Malignant Biliary Obstruction in Patients With Surgically Altered Anatomy: A Multicenter Prospective Registration Study 气囊肠镜辅助ERCP与超声内镜引导下胆道引流治疗手术改变患者不可切除的恶性胆道梗阻:一项多中心前瞻性登记研究。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-08-06 DOI: 10.1111/den.70010
Masahiro Itonaga, Mamoru Takenaka, Kenji Ikezawa, Tsukasa Ikeura, Masaaki Shimatani, Masanori Asada, Nao Fujimori, Ryota Sagami, Takeshi Ogura, Hajime Imai, Kazuyuki Matsumoto, Shuhei Shintani, Hideyuki Shiomi, Keiichi Hatamaru, Kosuke Minaga, Ryoji Takada, Ke Wan, Toshio Shimokawa, Masayuki Kitano

Background and Aims

The present prospective multicenter clinical trial compared the efficacy and safety of balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BEA-ERCP) and endoscopic ultrasound-guided biliary drainage (EUS-BD) as primary drainage methods for patients with surgically altered anatomy (SAA) and unresectable malignant biliary obstruction (MBO).

Methods

Technical and clinical success rates, procedure time, adverse events (AEs), and time to recurrent biliary obstruction (TRBO) were compared. Risk factors associated with technical failure were evaluated, and subgroup analysis investigating whether Roux-en-Y reconstruction affected the technical success rate was also performed.

Results

Patient characteristics were comparable between the BEA-ERCP (n = 54) and EUS-BD (n = 44) groups. Compared with the BEA-ERCP group, the EUS-BD group had a significantly higher technical success rate, a significantly shorter procedure time, comparable rates of clinical success and AEs, and comparable TRBO. Multivariate analysis showed that BEA-ERCP was an independent predictor of technical failure. Subgroup analysis revealed that the technical success rate was significantly higher with EUS-BD than with BEA-ERCP in patients with Roux-en-Y reconstruction, with no significant difference in those without Roux-en-Y reconstruction.

Conclusions

EUS-BD may be a more suitable primary drainage method than BEA-ERCP for patients with SAA and unresectable MBO, especially those with Roux-en-Y reconstruction (University Hospital Medical Information Network 000049224).

Trial Registration

UMIN000049224

背景与目的:本前瞻性多中心临床试验比较了球囊内镜辅助内镜逆行胆管造影术(BEA-ERCP)和内镜超声引导胆道引流术(EUS-BD)作为手术解剖改变(SAA)和不可切除的恶性胆道梗阻(MBO)患者的主要引流方法的有效性和安全性。方法:比较技术和临床成功率、手术时间、不良事件(ae)和复发性胆道梗阻(TRBO)时间。评估与技术失败相关的风险因素,并进行亚组分析,调查Roux-en-Y重建是否影响技术成功率。结果:BEA-ERCP组(n = 54)和EUS-BD组(n = 44)的患者特征具有可比性。与BEA-ERCP组相比,EUS-BD组的技术成功率明显更高,手术时间明显缩短,临床成功率和ae率相当,TRBO也相当。多因素分析表明,BEA-ERCP是技术故障的独立预测因子。亚组分析显示,Roux-en-Y重建患者的EUS-BD技术成功率明显高于BEA-ERCP,而未Roux-en-Y重建患者的技术成功率无显著差异。结论:对于SAA合并不可切除的MBO患者,尤其是Roux-en-Y重建患者,EUS-BD可能是比BEA-ERCP更适合的一级引流方法(大学医院医疗信息网000049224)。试验注册号:UMIN000049224。
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引用次数: 0
One Best Way or Many Voices? AI Strategies in the Era of Diverse Endoscopic Imaging for Ulcerative Colitis 一种最好的方式还是多种声音?溃疡性结肠炎内镜影像多样化时代的AI策略
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-08-05 DOI: 10.1111/den.70012
Yasuharu Maeda, Shin-ei Kudo, Masashi Misawa
<p>Should we rely solely on the most informative endoscopic observation modality, or should we instead harness the power of integrating all available techniques to gain a truly comprehensive understanding?</p><p>Following the introduction of the first generation of narrow-band imaging (NBI) in 2006, numerous image-enhanced endoscopy (IEE) technologies have entered clinical practice [<span>1</span>]. The utility of these modalities for lesion detection and characterization, demarcation line identification, and assessment of inflammatory activity has been well established [<span>2</span>]. Historically, the evolution of endoscopic diagnostics has largely been a search for the single best observation method. Yet, each of these techniques offers unique insights while also bearing inherent limitations. The choice of a single “best” method has often been shaped by individual clinical experience and practical considerations. However, recent advances in artificial intelligence (AI) are bringing us closer to a future in which endoscopists can utilize IEE modalities independent of individual experience or expertise.</p><p>In management of patients with ulcerative colitis (UC), endoscopic remission has emerged as a key therapeutic goal, particularly with the rise of treat-to-target strategies [<span>3</span>]. AI has shown promise in enhancing the assessment of endoscopic remission in patients with UC, and has more recently expanded its applications to prediction of histological remission and risk of relapse [<span>4</span>]. We recently evaluated the clinical utility of integrating AI models based on white-light imaging (WLI) [<span>5</span>] and NBI [<span>6</span>] during colonoscopy in patients with UC in clinical remission. Compared with the WLI model alone, the combined AI approach significantly improved specificity (from 42.2% to 61.5%) while maintaining sensitivity for the prediction of sustained clinical remission over 12 months [<span>7</span>]. Although this sequential use of dual AI-enabled modalities enhances diagnostic accuracy, it does so at the cost of increased examination time. An additional challenge lies in the development of diagnostic systems that can standardize assessments across different modalities.</p><p>In this issue of <i>Digestive Endoscopy</i>, Iacucci et al. [<span>8</span>] present an AI-enabled model capable of simultaneously analyzing different virtual chromoendoscopy (VCE) modalities. Their approach converts WLI into iScan2, iScan3, and NBI images. The neural network was trained to identify the acquisition modality of each frame, using 2535 frames extracted from 144 WLI, iScan, and NBI videos. Subsequently, they trained a cycleGAN model using 900 images from different modalities to enable inter-modality image conversion.</p><p>This model is revolutionary in two respects: First, it can generate multiple VCEs from WLIs regardless of the endoscopic platform manufacturer. Second, the generated images can be analyzed simultane
我们应该仅仅依靠最具信息量的内窥镜观察方式,还是应该利用整合所有可用技术的力量来获得真正全面的理解?自2006年推出第一代窄带成像(NBI)以来,许多图像增强内窥镜(IEE)技术已进入临床实践。这些模式在病变检测和表征、分界线识别和炎症活动评估方面的应用已经得到了很好的证实[10]。从历史上看,内窥镜诊断的发展在很大程度上是对单一最佳观察方法的探索。然而,每种技术都提供了独特的见解,同时也承受着固有的局限性。选择单一的“最佳”方法往往是由个人的临床经验和实际考虑所决定的。然而,人工智能(AI)的最新进展正使我们更接近这样一个未来:内窥镜医生可以利用独立于个人经验或专业知识的IEE模式。在溃疡性结肠炎(UC)患者的治疗中,内镜缓解已成为一个关键的治疗目标,特别是随着治疗-靶点策略[3]的兴起。人工智能在增强UC患者的内镜缓解评估方面显示出前景,最近已将其应用扩展到预测组织学缓解和复发风险bbb。我们最近评估了基于白光成像(WLI)[5]和NBI[6]的AI模型在UC临床缓解患者结肠镜检查中的临床应用。与单独的WLI模型相比,联合AI方法显著提高了特异性(从42.2%提高到61.5%),同时保持了预测12个月以上持续临床缓解的敏感性。虽然这种双人工智能模式的连续使用提高了诊断的准确性,但这样做的代价是增加了检查时间。另一个挑战在于开发诊断系统,使不同模式的评估标准化。在本期的《消化道内窥镜》中,Iacucci等人提出了一种支持ai的模型,能够同时分析不同的虚拟色内窥镜(VCE)模式。他们的方法将WLI转换为iScan2、iScan3和NBI图像。使用从144个WLI、iScan和NBI视频中提取的2535帧,训练神经网络来识别每帧的采集模式。随后,他们使用来自不同模态的900幅图像训练了一个cycleGAN模型,以实现模态间的图像转换。该模型在两个方面具有革命性:首先,无论内镜平台制造商是谁,它都可以从wi生成多个vce。其次,生成的图像可以同时分析,而不是顺序分析,这可能会解决关键的局限性,例如跨平台的诊断标准化和使用多种模式时延长的检查时间。他们的WLI + iScan2 + iScan3和WLI + NBI的多模态模型显示出明显的优势,在预测内窥镜缓解、组织学缓解和未来疾病发作方面优于相应的单模态模型。这种人工智能支持的同步多模态图像分析有可能改变UC粘膜愈合的传统解释,并标志着内窥镜诊断的范式转变。例如,它可能有助于解决长期存在的问题,即哪种方式对早期结肠炎相关肿瘤的检测最有效。这类病变通常只表现出细微的、特定形态的征象:WLI上有轻微的发红,NBI或iScan3上有微小的血管不规则,染色内窥镜上有更清晰的腺窝轮廓。将这些互补的视觉信号融合到一个单一的合成图像中,可以提高平坦或凹陷病变的可见性,标准化跨平台的“光学活检”,并降低漏检率。同样的方法也可以促进早期识别巴雷特相关的不典型增生和早期胃癌,这是通过类似的炎症驱动途径产生的。更广泛地说,它重新定义了辩论:我们不再需要在“最佳方法”或“所有方法”之间做出选择,相反,我们可以通过基于人工智能的计算机辅助检测[10],将从所有方法中获得的见解进行协同整合。展望未来,将跨模态转换与胶囊内窥镜相结合,可以提高对微小小肠血管异常的检测,这是消化道隐蔽性出血的主要原因,从而实现靶向治疗和主动止血。简而言之,多模态图像合成为评估炎症、肿瘤和血管病变提供了统一的框架,并有可能提高内窥镜在广泛疾病领域的诊断上限。 尽管具有很大的潜力,但在内窥镜实践中实施人工智能支持的同步多模态图像分析面临着几个关键挑战。首先,临床医生必须学会如何解释内在复杂的多模态信息,这些信息在临床实践中可能并不总是直接或直观的。其次,在不同专有内窥镜模式下生成图像引起了对知识产权和互操作性的担忧,可能会限制来自不同制造商的数据的无缝集成。第三,多模态人工智能分析对临床决策和治疗策略的现实影响仍有待与传统方法或单模态人工智能方法进行充分验证。最后,将这样一个系统整合到内镜手术的实时工作流程中,需要强大的系统架构和直观的用户界面,以确保自然有效地集成到临床实践中。我们坚信,通过逐步解决这些挑战,内窥镜诊断的新范式必将出现。综上所述,Iacucci等人提出的将AI与跨模态图像转换相结合的概念有可能重塑胃肠道成像的未来。这种方法可以在内窥镜成像多样性的时代建立卓越诊断的新标准。前田康春:概念化(导语),数据(文章)收集(对等),数据(文章)解释(导语),写作-原稿(导语)。工藤信惠:写作-审编(平等),监督(领导)。三泽正志:写作——审编(主导)和监督(平等)。Yasuharu Maeda是DEN Open的副主编。Masashi Misawa是《消化道内窥镜》杂志的副主编。工藤信荣没有需要披露的利益冲突。一种新颖的人工智能转换,可同时生成多模态图像,以评估溃疡性结肠炎的炎症和预测预后-(带视频)。https://doi.org/10.1111/den.15067。
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引用次数: 0
World Endoscopy Organization's Response to the World Health Organization's Global Initiative on Artificial Intelligence for Health 世界内窥镜检查组织对世界卫生组织关于人工智能促进卫生的全球倡议的回应。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-08-04 DOI: 10.1111/den.70011
Nayantara Coelho-Prabhu, Purnima Bhat, Rakesh Kalapala, Junaid Mushtaq, Hisao Tajiri, Yuichi Mori

In response to the World Health Organization's (WHO) Global Initiative on Artificial Intelligence (AI) for Health, the World Endoscopy Organization (WEO) highlights the unique challenges and opportunities AI presents for gastrointestinal endoscopy, particularly in resource-limited settings. While AI technologies have shown promise in improving diagnostic accuracy and efficiency in high-resource environments, their implementation in low- and middle-income countries is hindered by infrastructural, economic, regulatory, and training barriers. This commentary explores how these challenges may exacerbate existing healthcare disparities, emphasizing the need for localized datasets, affordable AI models, simplified regulatory frameworks, and workforce capacity building. The WEO supports WHO's call for equitable AI deployment and advocates for region-specific solutions, including mobile and offline AI tools, public-private partnerships, locally developed algorithms aligned with prevalent disease patterns, and a flexibly adapted regulatory framework. By leveraging WEO's training networks and fostering collaboration among governments, clinicians, and industry, the integration of AI into endoscopy can become more accessible and relevant to underserved populations. The commentary underscores that AI should not be seen as a luxury but as a tool to bridge global disparities in care quality. Ensuring responsible and inclusive AI integration requires both global coordination and context-specific adaptations to truly benefit all healthcare systems.

为响应世界卫生组织(世卫组织)关于人工智能促进卫生的全球倡议,世界内窥镜检查组织(WEO)强调了人工智能为胃肠道内窥镜检查带来的独特挑战和机遇,特别是在资源有限的情况下。虽然人工智能技术在提高高资源环境中的诊断准确性和效率方面显示出希望,但在低收入和中等收入国家实施人工智能技术受到基础设施、经济、监管和培训障碍的阻碍。本评论探讨了这些挑战如何加剧现有的医疗保健差距,强调需要本地化数据集、负担得起的人工智能模型、简化的监管框架和劳动力能力建设。《世界经济展望》支持世卫组织关于公平部署人工智能的呼吁,并倡导针对特定区域的解决方案,包括移动和离线人工智能工具、公私伙伴关系、当地开发的符合流行疾病模式的算法,以及灵活调整的监管框架。通过利用WEO的培训网络并促进政府、临床医生和行业之间的合作,将人工智能整合到内窥镜检查中,可以使服务不足的人群更容易获得和相关。评论强调,人工智能不应被视为奢侈品,而应被视为弥合全球护理质量差距的工具。确保负责任和包容性的人工智能整合既需要全球协调,也需要根据具体情况进行调整,以真正使所有医疗保健系统受益。
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引用次数: 0
Safety and Feasibility of Intensive Downstaging Polypectomy With Low-Power Pure-Cut Hot Snare Polypectomy in Patients With Familial Adenomatous Polyposis (With Video) 家族性腺瘤性息肉患者低倍率纯切热陷阱息肉切除术的安全性和可行性。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-08-03 DOI: 10.1111/den.70009
Yasuhiro Tani, Satoki Shichijo, Yuta Fujimoto, Yoshiaki Ando, Gentaro Tanabe, Yuya Asada, Tomoya Ueda, Daiki Kitagawa, Atsuko Kizawa, Takehiro Ninomiya, Yuki Okubo, Minoru Kato, Shunsuke Yoshii, Takashi Kanesaka, Koji Higashino, Noriya Uedo, Ryu Ishihara, Tomoki Michida, Yoji Takeuchi

Intensive endoscopic resection for downstaging polyp burden (IDP) strategically prevents colorectal cancer and potentially avoiding surgical treatment in patients with familial adenomatous polyposis (FAP). The safety and efficacy of low-power pure-cut hot-snare polypectomy (LPPC-HSP) for sporadic colorectal polyps have been recently reported. This prospective study, therefore, aimed to clarify the safety and efficacy of IDP in combination with LPPC-HSP in patients with FAP. This single-centre prospective study recruited patients diagnosed with FAP and scheduled for IDP. The primary outcome was the rate of severe adverse events including postoperative bleeding and perforation. The secondary outcomes were adverse events per the Clavien–Dindo classification, abdominal pain, hematochezia after the procedure, emergency colonoscopy, and rehospitalization. Patients with FAP who underwent IDP with conventional hot snare polypectomy using bipolar snares from January 2021 to December 2021 were examined as historical controls (bipolar group) for comparison with patients who underwent IDP with LPPC-HSP (LPPC-HSP group). Among 36 patients with FAP enrolled between July 2023 and June 2024, 33 were included in the analysis. The median age was 31 years, and 16 patients were male. A total of 6581 polyps were resected. Two patients (one with postoperative bleeding and the other with postoperative bleeding and delayed perforation) in the LPPC-HSP group (n = 33) and four patients (all with postoperative bleeding) in the bipolar group (n = 37) experienced severe adverse events (p = 0.677). In conclusion, LPPC-HSP is feasible and may be considered a treatment option for patients with FAP undergoing IDP.

Trial Registration

UMIN-CTR: UMIN000051414

对于家族性腺瘤性息肉病(FAP)患者,强化内镜切除降低息肉负担(IDP)可以有效预防结直肠癌,并有可能避免手术治疗。最近报道了低倍率纯切热陷阱息肉切除术(LPPC-HSP)治疗散发性结直肠息肉的安全性和有效性。因此,本前瞻性研究旨在阐明IDP联合LPPC-HSP治疗FAP患者的安全性和有效性。这项单中心前瞻性研究招募了诊断为FAP并计划进行IDP的患者。主要结果是严重不良事件的发生率,包括术后出血和穿孔。次要结局是Clavien-Dindo分类的不良事件、腹痛、术后便血、紧急结肠镜检查和再住院。2021年1月至2021年12月,采用双相陷阱进行常规热陷阱息肉切除术的FAP患者作为历史对照(双相组),与采用LPPC-HSP进行IDP的患者(LPPC-HSP组)进行比较。在2023年7月至2024年6月期间入组的36例FAP患者中,33例纳入分析。中位年龄31岁,男性16例。共切除息肉6581例。LPPC-HSP组2例(1例术后出血,1例术后出血并延迟穿孔)(n = 33),双相组4例(n = 37)(均为术后出血)发生严重不良事件(p = 0.677)。总之,LPPC-HSP是可行的,可以考虑作为FAP患者IDP的治疗选择。试验注册:umin-ctr: umin000051414。
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引用次数: 0
Gel Immersion Technique Provides Stable and Clear Magnified Endoscopic Views of Lesions Around the Esophagogastric Junction 凝胶浸泡技术提供了稳定和清晰的食管胃交界周围病变的放大内镜视图。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-07-30 DOI: 10.1111/den.70005
Ippei Tanaka, Yohei Nishikawa, Haruhiro Inoue

Endoscopic observation of lesions located at the esophagogastric junction (EGJ) is technically challenging. This difficulty primarily arises from the anatomical narrowness of the EGJ, which makes it difficult to maintain an optimal distance between the endoscope and the target lesion. While some endoscopists employ the water-flooding technique, the rapid flow of water into the stomach prevents stable observation. Moreover, excessive water use increases the risk of aspiration. Gel immersion endoscopy is a useful method for securing a clear visual field during hemostatic procedure [1, 2]. In this report, we further highlight its effectiveness in magnified endoscopic observation.

A 68-year-old man was referred to our hospital for further evaluation of suspected Barrett's esophageal cancer. Upper gastrointestinal endoscopy revealed a reddish, depressed lesion at the 2 o'clock position in the EGJ area (Figure 1a). Magnified endoscopy with narrow-band imaging was performed using the gel immersion technique (Figure 1b), with a transparent hood attached to the distal tip of the endoscope. The gel we used was “VISCOCLEAR” (Otsuka Pharmaceutical Factory, Tokushima, Japan), which was administered through the endoscope using a standard 50 mL syringe. To minimize bubble formation during observation, we slowly pushed the syringe plunger to gently introduce the gel into the esophagus. Thanks to its specific viscosity, the gel remained in the EGJ without flowing into the stomach, allowing for a stable and clear endoscopic view without the need for constant infusion. Moreover, the relatively low intraluminal pressure under the gel permitted gentle contact, minimizing the risk of tissue damage. The time required from gel infusion to the completion of magnified observation was < 2 min. The lesion was endoscopically diagnosed as benign, and a biopsy revealed only inflammatory changes (Group 1).

In conclusion, the gel immersion technique may offer a safe, stable, and effective approach for endoscopic observation of lesions in the EGJ area.

I.T.: investigation and endoscopic procedure, writing – original draft preparation. I.T., Y.N.: conceptualization and methodology. Y.N., H.I.: writing – review and editing. H.I.: supervision and project administration. All authors: approval of final manuscript.

The authors declare no conflicts of interest.

内镜下观察位于食管胃交界处(EGJ)的病变在技术上具有挑战性。这一困难主要来自于EGJ的解剖狭窄,这使得在内窥镜和目标病变之间难以保持最佳距离。虽然一些内窥镜医生采用水驱技术,但水进入胃的快速流动妨碍了稳定的观察。此外,过度用水增加了误吸的危险。凝胶浸泡内窥镜是止血过程中确保清晰视野的有效方法[1,2]。在本报告中,我们进一步强调了其在放大内镜观察中的有效性。一名68岁男性因疑似巴雷特食管癌转介至我院进一步评估。上消化道内窥镜显示在EGJ区域2点钟位置有一个红色凹陷病灶(图1a)。采用凝胶浸泡技术进行窄带放大内镜检查(图1b),内镜远端附着透明罩。我们使用的凝胶是“VISCOCLEAR”(日本德岛大冢制药厂),使用标准的50ml注射器通过内窥镜给药。为了减少观察过程中气泡的形成,我们缓慢地推动注射器柱塞,轻轻地将凝胶引入食道。由于其特定的粘度,凝胶保持在EGJ中,而不流入胃中,无需不断输液,即可获得稳定而清晰的内镜视图。此外,凝胶下相对较低的腔内压力允许轻度接触,将组织损伤的风险降至最低。从注射凝胶到完成放大观察所需时间为2min。病变经内镜诊断为良性,活检仅显示炎性改变(组1)。综上所述,凝胶浸泡技术为内镜下观察EGJ区域病变提供了一种安全、稳定、有效的方法。i.t., y.n.:概念化和方法论。写作——评论和编辑。六、监督和项目管理。所有作者:批准最终稿件。作者声明无利益冲突。
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引用次数: 0
Cricopharyngeal Per Oral Endoscopic Myotomy (C-POEM) With a Novel Therapeutic Gastroscope 环咽经口内镜肌切开术(C-POEM)与一种新型治疗性胃镜。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-07-30 DOI: 10.1111/den.70003
Niroshan Muwanwella, Krish Ragunath

Endoscopic cricopharyngeal myotomy (C-POEM) is an evolving, minimally invasive technique for treating cricopharyngeal dysfunction [1, 2], which may result from conditions such as idiopathic cricopharyngeal bar, Parkinson's Disease, or Inclusion Body Myositis. The procedure is technically challenging due to the confined space of the hypopharynx (Figure 1). Traditionally, C-POEM is performed using a standard gastroscope, which has a 9.9 mm outer diameter and a 2.3 mm working channel. With the addition of a conical distal attachment cap, a mucosal incision of approximately 15 mm is typically required to access the submucosal space, further complicating the procedure in anatomically restricted areas. We present a video case demonstrating the use of a next-generation slim therapeutic gastroscope—the Fujifilm EG-840TP—in a successful C-POEM. This scope introduces several important technical improvements: Slimmer outer diameter: 7.9 mm versus 9.9 mm (standard scope), allowing easier maneuverability in the hypopharynx and proximal esophagus; larger working channel: 3.2 mm versus 2.3 mm, enabling the simultaneous use of instruments and suction; smaller mucosal incision required: A 10 mm mucosal incision is sufficient, even with the distal cap in place; and enhanced tip angulation of 210° upward and 160° downward flexion, improving access and precision in tight anatomical spaces (Figure 2). These design enhancements facilitate safer and more efficient dissection, improve procedural control, and reduce tissue trauma. A conical cap (DH-083ST—FujiFilm, Japan) with a 3.5 mm distal stiff section from the tip of the gastroscope and a 7 mm inner diameter of the distal end was also used for the C-POEM. Our case highlights the feasibility, safety, and therapeutic potential of the EG-840TP in upper esophageal interventions [3, 4], suggesting that it may set a new standard for C-POEM and similar endoscopic procedures in narrow anatomical regions.

Niroshan Muwanwella: conceptualization (lead), resources, writing – original draft (lead). Krish Ragunath: conceptualization (supporting), writing – review and editing.

Approval of the research protocol by an Institutional Reviewer Board: None.

Informed consent: Informed consent obtained from patient to publish de-identified endoscopic images and videos.

Registry and the registration no. of the study/trial: None.

Animal studies: None.

The authors declare no conflicts of interest. Prof Krish Ragunath is an Associate Editor of Digestive Endoscopy.

内镜环咽肌切开术(C-POEM)是一种不断发展的微创技术,用于治疗环咽功能障碍[1,2],这种功能障碍可能由特发性环咽阻滞、帕金森病或包涵体肌炎等疾病引起。由于下咽的狭窄空间,该手术在技术上具有挑战性(图1)。传统上,C-POEM使用标准胃镜进行,其外径为9.9 mm,工作通道为2.3 mm。随着锥形远端附着帽的增加,通常需要大约15mm的粘膜切口才能进入粘膜下空间,这使得解剖受限区域的手术更加复杂。我们展示了一个视频案例,展示了在一个成功的C-POEM中使用新一代超薄治疗胃镜-富士eg - 840tp。该瞄准镜引入了几项重要的技术改进:更细的外径:7.9毫米与9.9毫米(标准瞄准镜)相比,更容易在下咽和食管近端操作;更大的工作通道:3.2 mm vs 2.3 mm,可以同时使用仪器和吸力;需要更小的粘膜切口:10毫米的粘膜切口就足够了,即使远端帽已经到位;提高尖端角度210°向上和160°向下弯曲,提高狭窄解剖空间的接触和精度(图2)。这些设计的改进促进了更安全、更有效的解剖,改善了程序控制,减少了组织创伤。C-POEM也使用锥形帽(DH-083ST-FujiFilm, Japan),其远端僵硬部分距胃镜尖端3.5 mm,远端内径为7 mm。我们的病例强调了EG-840TP在上食管介入治疗中的可行性、安全性和治疗潜力[3,4],这表明它可能为狭窄解剖区域的C-POEM和类似的内镜手术树立新的标准。Niroshan Muwanwella:构思(导),资源,写作-原稿(导)。Krish Ragunath:概念化(支持),写作-审查和编辑。机构审查委员会批准研究方案:无。知情同意:获得患者发布去识别内镜图像和视频的知情同意。注册表及注册编号研究/试验:无。动物实验:没有。作者声明无利益冲突。Krish Ragunath教授是《消化内窥镜》杂志的副主编。
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引用次数: 0
Size Matters in Rectal Neuroendocrine Tumors: Redefining Risk Thresholds for Surveillance and Management 直肠神经内分泌肿瘤的大小问题:重新定义监测和管理的风险阈值。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-07-27 DOI: 10.1111/den.70006
Shinya Sugimoto, Hayato Nakagawa
<p>The widespread implementation of screening colonoscopy in recent years has led to a marked increase in detecting small asymptomatic rectal neuroendocrine tumors (NETs) [<span>1</span>]. Accumulating evidence from endoscopic observations, histopathological assessments of resected specimens, and longitudinal clinical follow-up has helped elucidate several risk factors for metastatic potential. These include central depression, tumor size, Ki-67 labeling index, mitotic count, and lymphovascular invasion (LVI) [<span>2, 3</span>]. The current clinical practice guidelines for managing localized rectal NETs demonstrate considerable regional variation, largely reflecting differing interpretations of metastatic risk. Prominent divergences are evident among international guidelines, particularly those issued by the European Neuroendocrine Tumor Society (ENETS) [<span>4</span>], National Comprehensive Cancer Network (NCCN) [<span>5</span>], and Japan Neuroendocrine Tumor Society (JNETS) [<span>6</span>]. Both the ENETS and NCCN guidelines primarily emphasize tumor size as the principal criterion for determining therapeutic strategy and surveillance protocols. In contrast, the JNETS guidelines advocate a more aggressive approach, even in relatively small-sized lesions. According to Western consensus, rectal NETs measuring 2.0 cm or less are generally considered suitable for local excision, either via endoscopic or transanal techniques. However, tumors exceeding 2.0 cm are regarded as clear indications for radical resection with regional lymphadenectomy. The NCCN, in particular, supports local excision of well-differentiated NETs in the 1.0–2.0 cm range, despite evidence suggesting a non-negligible incidence of lymph node metastasis in this subgroup. Similarly, the ENETS permits endoscopic resection of tumors within the 1.0–2.0 cm range, provided that there is no evidence of muscularis propria invasion or lymph node involvement on imaging. Radical surgical procedures such as total mesorectal excision are reserved for tumors exceeding 2.0 cm or those displaying high-risk pathological features.</p><p>In contrast, the JNETS guidelines recommend radical surgical resection—specifically, proctectomy with regional lymph node dissection—for any rectal NET measuring 1.0 cm or greater. This recommendation also applies to tumors classified as grade 2 (NET G2) according to the World Health Organization classification, neuroendocrine carcinomas (NECs), and lesions demonstrating signs of deep submucosal or muscular invasion. In essence, the Japanese criteria for oncologic resection adopt a lower threshold—based on either a tumor size of ≥ 1.0 cm or high histologic grade—reflecting a more precautionary and risk-averse clinical philosophy. These divergences in clinical approach have prompted ongoing debate. The Japanese strategy prioritizes eliminating even a modest risk of occult lymph node metastasis. However, this strategy might result in overtreatment in patients wit
近年来,筛查性结肠镜检查的广泛实施,使得小的无症状直肠神经内分泌肿瘤(NETs)[1]的检出率显著增加。从内窥镜观察、切除标本的组织病理学评估和纵向临床随访中积累的证据有助于阐明转移潜力的几个危险因素。这些指标包括中枢凹陷、肿瘤大小、Ki-67标记指数、有丝分裂计数和淋巴血管侵袭(LVI)[2,3]。目前的临床实践指南显示出相当大的地区差异,很大程度上反映了对转移风险的不同解释。国际指南之间存在明显的分歧,特别是欧洲神经内分泌肿瘤学会(ENETS)[4]、国家综合癌症网络(NCCN)[5]和日本神经内分泌肿瘤学会(JNETS)[6]发布的指南。ENETS和NCCN指南都主要强调肿瘤大小是确定治疗策略和监测方案的主要标准。相比之下,JNETS指南提倡更积极的方法,即使是相对较小的病变。根据西方共识,一般认为小于或等于2.0 cm的直肠NETs适合通过内镜或经肛技术进行局部切除。然而,超过2.0 cm的肿瘤被认为是根治性切除和局部淋巴结切除术的明确适应症。NCCN尤其支持1.0-2.0 cm范围内分化良好的NETs的局部切除,尽管有证据表明该亚组中淋巴结转移的发生率不可忽略。同样,ENETS允许内镜切除1.0-2.0 cm范围内的肿瘤,前提是影像学上没有固有肌层侵犯或淋巴结受累的证据。根治性手术,如全肠系膜切除,保留用于肿瘤超过2.0 cm或表现出高危病理特征。相比之下,JNETS指南推荐根治性手术切除——特别是直肠净淋巴结切除术和区域淋巴结清扫——对于任何大于1.0 cm的直肠净淋巴结。这一建议也适用于世界卫生组织分级为2级(NET G2)的肿瘤、神经内分泌癌(NECs)和有深部粘膜下或肌肉浸润征象的病变。本质上,日本肿瘤切除术的标准采用较低的阈值-基于肿瘤大小≥1.0 cm或高组织学分级-反映了更预防和规避风险的临床理念。这些临床方法上的分歧引发了持续的争论。日本的策略优先消除即使是适度的潜在淋巴结转移风险。然而,这种策略可能会导致风险最小的小的分化良好的肿瘤患者过度治疗。相比之下,西方指南强调通过限制小于2.0 cm的肿瘤的根治性手术来避免过度治疗,即使这需要接受低但临床相关的淋巴结传播风险。历史数据为这些不同的哲学提供了重要的背景。小于1.0 cm的直肠类癌通常与极低的转移发生率相关,而1.0 - 2.0 cm的直肠类癌则具有适度但明显升高的风险。相反,大于2.0 cm的肿瘤始终与淋巴结转移的可能性高相关。这些风险梯度有助于阐明区域指南阈值背后的基本原理。西方指南使用2.0 cm的临界值,隐含地接受1.0 - 2.0 cm病变相关的中间风险,支持器官保存和降低治疗相关的发病率。相反,日本的指南寻求在肿瘤大小超过1.0厘米或表现出侵袭性病理特征时,先发制人地解决转移风险上升的问题。在本期的《消化道内窥镜》杂志上,Kim等人的研究提供了有价值的数据,支持对当前直肠NETs基于尺寸的截止阈值进行关键的重新评估。利用1011名患者的大队列,作者提出了一个风险适应管理框架,结合肿瘤大小和生物学特征,如组织学分级,以实现更个性化的治疗策略。他们的发现为完善现有的分类系统提供了一个令人信服的理论基础,通过引入中间阈值来更精确地对复发风险进行分层。确定两个特定的肿瘤大小阈值,0.7和1.5厘米,是本研究最具影响力的贡献之一,它比1.0和2.0厘米的传统基准提供了更大的区分能力。0.7 cm阈值对于内镜切除治疗的G1肿瘤特别有意义。 值得注意的是,在随访期间,没有一个G1 NETs尺寸为0.7 cm或更小,切除边缘为阴性,没有LVI的证据,发生复发。这使得在该阈值下的复发预测达到100%的敏感性。这些发现表明,真正的小G1肿瘤(明显小于1.0 cm)具有极低的转移性扩散风险,在适当选择的病例中,可能不需要常规的切除后监测。先前的多中心研究结果支持0.7 cm阈值的生物学合理性,这些研究表明,0.6 cm或更小的直肠NETs与淋巴结转移无关,而0.7-1.0 cm的NETs约有10%的淋巴结受病灶[2,5]。因此,0.6-0.7 cm范围内的阈值似乎可以有效地将转移潜力可忽略的病变与那些尽管仍然很低但具有临床相关风险的病变区分开来。实际上,这可能意味着在完全切除0.5 cm G1 NET后,不需要进行密集的影像学随访。然而,0.9 cm或1.0 cm的病变,尽管比传统的1.0 cm切点小,但考虑到隐匿转移的可能性更高,可能需要更密切的观察甚至额外的治疗。第二个阈值为1.5 cm,来自手术治疗的G1伴LVI肿瘤的亚组分析。1.5 cm或更小的肿瘤没有复发,而只有大于1.5 cm的肿瘤才会复发。这些发现表明,对于这种大小的肿瘤,即使存在诸如LVI等不良病理特征,治疗性手术仍然是必不可少的。如果得到证实,这一阈值可能会加强术后风险分层。例如,伴有LVI但未累及淋巴结的1.2 cm G1 NET可能不需要辅助治疗或强化监测。相比之下,1.8 cm lvi阳性肿瘤可考虑高风险,可能受益于辅助治疗或密切的长期随访。重要的是,1.5厘米的阈值弥补了目前西方和日本治疗指南之间的差距。JNET指南建议对大于1.0 cm的肿瘤进行根治性手术;Kim等人的发现支持这种方法治疗1.5厘米的肿瘤。另一方面,西方的做法有时允许局部治疗1.5厘米的病变,现在可能需要重新评估,因为这个大小似乎接近手术治疗的上限。虽然Kim等人纳入了G2 NETs病例和少数nec病例,但数据仍然不足以得出治疗这些更高级别肿瘤的明确结论。该分析仅涉及35个G2 NETs和9个nec。作者报告说,G2肿瘤的预后比G1差,大约四分之一的肿瘤出现淋巴结转移,复发率和死亡率可能更高。然而,G2病例数量有限,仅占队列的3.5%,可能导致统计能力不足,无法在该亚组中进行有意义的风险分层。G2肿瘤是否会遵循与G1类似的大小相关的风险模式,或者是否所有的G2肿瘤,即使是非常小的肿瘤,都会有很大的风险,目前还不清楚。作者建议对所有G2 NETs进行定期随访,无论其大小,基本上将其视为一致的高风险。虽然这是一个谨慎而合理的结论,但未来需要对直肠G2肿瘤进行大规模研究或登记,以明确风险是否会因大小而变化,例如,0.5 cm的G2 NET是否真的与1.5 cm病变具有相同的风险。直肠NECs同样未被充分代表,仅包括9例。这些肿瘤很少见,但侵袭性很强,从目前的数据集无法得出有意义的结论。然而,观察到的不良结果使它们与G2肿瘤一致。需要进一步的研究来确定局部NEC的最佳治疗策略。目前,大多数临床指南根据其高级别组织学推断,并建议根治性手术和全身治疗,即使是小病变。综上所述,Kim等人提出的0.7 cm和1.5 cm的阈值为直肠小NETs患者的风险分层提供了一个具有临床意义的双层模型。尽管对于G2 NETs和nec等高级别肿瘤的数据仍然有限,但研究结果支持在真正低风险的G1肿瘤中采用更保守的治疗方法。具体而言,完全切除的G1肿瘤尺寸为0.7 cm或更小,边缘阴性且无LVI的患者可能不需要进行强化监测。然而,即使切除标本,在准确确定肿瘤是否会测量0时,也存在固有的局限性和潜在的困难。 通过病理评估,精确地将肿瘤分类为WHO G1或G2,或可靠地确定LVI bb0的存在或不存在。根据Pa
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引用次数: 0
Endoscopic Transpapillary Gallbladder Drainage for Gangrenous Cholecystitis: A Minimally Invasive Approach Under Scrutiny 内镜下经乳头胆囊引流治疗坏疽性胆囊炎:一种微创方法。
IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-07-25 DOI: 10.1111/den.70004
Yoshihide Kanno
<p>Gangrenous cholecystitis (GC) is a life-threatening form of acute cholecystitis characterized by full-thickness necrosis of the gallbladder wall. The pathogenesis involves ischemia and vascular compromise, typically resulting from prolonged inflammation, cystic artery obstruction, or elevated intraluminal pressure [<span>1</span>]. Histologically, GC is marked by transmural necrosis, hemorrhaging, and dense neutrophilic infiltration. The gallbladder wall may exhibit complete mucosal necrosis, vascular thrombosis, and, in some cases, intramural abscesses. These features underscore the severity of the disease and its high risk of complications, including perforation and peritonitis.</p><p>Emergency cholecystectomy remains the standard treatment for GC [<span>2</span>]. This is largely because decompression via gallbladder puncture (traditionally through a percutaneous route and more recently via endosonographically created routes) has been associated with a high risk of perforation. The friable wall of a gangrenous gallbladder lacks the structural integrity to secure a catheter, unlike resilient muscular tissue. Once punctured, the fragile cystic wall, which barely maintains its shape under high intraluminal pressure, may collapse irreparably.</p><p>In contrast, endoscopic transpapillary gallbladder drainage (ETGBD) offers a non-puncture alternative that could facilitate recovery in selected GC cases. If the gangrenous changes are barely reversible, non-puncture drainage may support conservative healing. Even when irreversible mucosal damage has occurred, the gallbladder may retain its structure following the resolution of inflammation, provided full-thickness necrosis is absent and the muscular layer can just maintain its structural integrity. ETGBD, the only drainage modality that does not involve direct gallbladder puncture, may serve as an alternative in severe cholecystitis cases where other approaches, including surgery, are contraindicated.</p><p>However, ETGBD presents significant technical challenges. A recent meta-analysis has reported a pooled technical success rate of 83% (95% CI: 80.1–85.5; <i>I</i><sup>2</sup> = 29) [<span>3</span>]. In comparison, percutaneous drainage and EUS-guided drainage achieve success rates of 99% and 95%, respectively. Consequently, ETGBD cannot currently replace these more established procedures. Moreover, even if technically successful, ETGBD carries a risk of post-procedural pancreatitis.</p><p>In addition, its clinical success rate is modest. Mohan et al. have reported a pooled clinical success rate of 88% for ETGBD, compared to 89% for percutaneous drainage and 97% for EUS-guided drainage [<span>3</span>]. ETGBD inherits the limitations of both alternatives: irrigation cannot be performed through an external tube (like EUS-guided drainage), and it uses a relatively narrow catheter (like percutaneous drainage) [<span>4</span>].</p><p>Therefore, ETGBD may be most appropriate for patients with contraindi
坏疽性胆囊炎(GC)是一种危及生命的急性胆囊炎,其特征是胆囊壁全层坏死。其发病机制包括缺血和血管损伤,通常由长期炎症、囊性动脉阻塞或腔内压升高引起。组织学上,GC表现为跨壁坏死、出血和密集的中性粒细胞浸润。胆囊壁可表现为完全的粘膜坏死,血管血栓形成,在某些情况下,还可出现壁内脓肿。这些特征强调了疾病的严重性及其并发症的高风险,包括穿孔和腹膜炎。急诊胆囊切除术仍然是胃癌的标准治疗方法。这在很大程度上是因为通过胆囊穿刺减压(传统上通过经皮途径,最近通过超声创建的途径)与穿孔的高风险相关。与弹性肌肉组织不同,坏疽胆囊脆弱的壁缺乏结构完整性来固定导管。脆弱的囊壁在腔内高压下几乎无法维持其形状,一旦被刺破,囊壁可能会不可挽回地坍塌。相比之下,内镜下经乳头胆囊引流(ETGBD)提供了一种非穿刺的选择,可以促进选定的GC病例的恢复。如果坏疽性改变几乎不可逆,非穿刺引流可支持保守治疗。即使发生了不可逆的粘膜损伤,只要没有全层坏死,肌肉层能保持其结构的完整性,胆囊在炎症消退后仍能保持其结构。ETGBD是唯一一种不涉及直接胆囊穿刺的引流方式,可作为严重胆囊炎病例的一种替代方法,其中包括手术。然而,ETGBD提出了重大的技术挑战。最近的一项荟萃分析报告了技术成功率为83% (95% CI: 80.1-85.5; I2 = 29)。经皮引流和eus引导引流的成功率分别为99%和95%。因此,ETGBD目前不能取代这些更成熟的程序。此外,即使技术上成功,ETGBD也有术后胰腺炎的风险。此外,其临床成功率不高。Mohan等人报道了ETGBD的临床总成功率为88%,而经皮引流为89%,eus引导引流为97%。ETGBD继承了这两种替代方法的局限性:不能通过外置管(如eus引导引流)进行灌洗,并且使用相对狭窄的导管(如经皮引流)[4]。因此,ETGBD可能最适合于对所有其他引流方式有禁忌症的患者,例如那些有严重凝血障碍或大量腹水的患者。此外,对于接受ERCP取出胆管结石的患者,也可考虑采用该方法,为同时进行胆囊引流提供机会。对于晚期恶性肿瘤患者,使用ETGBD可能有助于避免手术和永久性外引流的需要。此外,GC本身可能成为ETGBD的新适应症。在Nakahara等人的一项回顾性研究中,比较了坏疽性和非坏疽性胆囊炎[5]患者的ETGBD结果。GC的定义是通过对比增强的CT表现,如缺乏壁增强、壁不规则或无壁、腔内膜、囊周脓肿、壁或腔内气体。技术成功率分别为86%对92%,临床成功率为79%对92%,不良事件发生率为28%对16%。虽然坏疽组的预后较差,但超过三分之二的患者(86% × 79% = 67.9%)取得了临床成功。考虑到胃癌通常需要紧急手术,这个结果在高度复杂、高风险的患者中是可以接受的。如果在未来的研究中确定预测技术和临床成功的因素,可能会有所帮助。此外,应明确临床或影像学特征确定的禁忌症。必须解决技术挑战,使ETGBD更广泛地适用。现有的报告主要来自由具有丰富ETGBD经验的专家组成的高容量中心[6-8]。一般情况下,结果可能不太理想。技术上的改进必须不仅包括提高操作人员的熟练程度,还包括进入囊管的标准化技术,开发用于导航扭曲解剖结构的导丝,以及优化支架的顺利部署。此外,ETGBD与经皮引流的临床对比数据缺乏,迫切需要。 必须仔细评估ETGBD的程序负担,包括更长的持续时间、更高的镇静剂要求和失败后恶化的风险。应对不良事件的策略,特别是胰腺炎和胆囊管穿孔,以及处理失败的ETGBD,包括随后的干预措施,应该明确概述[9,10]。一旦这些局限性得到充分理解和解决,ETGBD的临床适应症就可以更精确地描述。尽管存在挑战,但ETGBD在某些情况下可能成为一种可行的选择,特别是在凝血功能障碍、腹水、并发胆管结石或坏疽性胆囊炎等患者不适合手术的情况下。作者声明无利益冲突。这篇文章链接到Nakahara等人的论文。要查看本文,请访问https://doi.org/10.1111/den.15050
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Digestive Endoscopy
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