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Reply to "Questions regarding 'Effects of potassium supplementation on plasma aldosterone: a systematic review and meta-analysis' by McNally et al." 对 "关于 McNally 等人撰写的'补钾对血浆醛固酮的影响:系统综述和荟萃分析'的问题 "的答复
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-10-31 DOI: 10.1097/HJH.0000000000003870
Luca Faconti
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引用次数: 0
Association of mid-regional pro-adrenomedullin with office and 24-h ambulatory blood pressure in a Swiss general population sample. 瑞士普通人群样本中的中区前肾上腺髓质素与办公室血压和 24 小时流动血压的关系。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-09-18 DOI: 10.1097/HJH.0000000000003866
Julia Baldwin, Michel Burnier, Belen Ponte, Daniel Ackermann, Menno Pruijm, Bruno Vogt, Murielle Bochud

Objective: Adrenomedullin (ADM) is a potent vasodilator. The association between plasma ADM levels and blood pressure (BP) remains unclear. We assessed the association between mid-regional-pro-ADM (MR-proADM) and BP in a multicenter population- and family-based cohort.

Methods: We used data from the Swiss Kidney Project on Genes in Hypertension (SKIPOGH). We included participants present at both baseline and 3-year follow-up (N = 843). We examined the association of baseline MR-proADM with baseline office and 24 h ambulatory BP as well as the 3-year change in office BP. In secondary analyses, we studied the association between baseline MR-proADM and 3-year changes in pulse wave velocity (PWV), renal resistive index (RRI) and augmentation index (AI). Mixed-effects linear regression models were used.

Results: In cross-sectional analyses, MR-proADM was negatively associated with office, 24-h and daytime diastolic BP (DBP). MR-proADM was positively associated with nighttime systolic BP (SBP). In longitudinal analyses, baseline MR-proADM was associated with an increase in office SBP and pulse pressure (PP) over 3 years [β (95% CI): 8.2 (0.4, 15.9) and β (95% CI): 6.4 (0.3, 12.4), respectively] but not with changes in PWV, RRI and AI.

Conclusions: The cross-sectional negative association of MR-proADM with DBP is in line with known vasodilatory properties of ADM. The positive association between MR-proADM and nighttime SBP at baseline may reflect endothelial dysfunction believed to be part of the pathogenesis of nocturnal hypertension. The association of higher baseline MR-proADM levels with increased SBP and PP at 3-year follow-up suggests that ADM levels could be a marker of cardiovascular risk.

目的:肾上腺髓质素(ADM)是一种有效的血管扩张剂:肾上腺髓质素(ADM)是一种强效的血管扩张剂。血浆 ADM 水平与血压(BP)之间的关系仍不清楚。我们在一个多中心人群和家庭队列中评估了中区域前ADM(MR-pro-ADM)与血压之间的关系:我们使用了瑞士高血压基因肾脏项目(SKIPOGH)的数据。我们纳入了基线和 3 年随访的参与者(N = 843)。我们研究了基线 MR-proADM 与基线办公室血压和 24 小时流动血压以及办公室血压 3 年变化的关系。在辅助分析中,我们研究了基线 MR-proADM 与脉搏波速度 (PWV)、肾阻力指数 (RRI) 和增强指数 (AI) 3 年变化之间的关系。研究采用了混合效应线性回归模型:在横断面分析中,MR-proADM 与办公室、24 小时和白天舒张压 (DBP) 呈负相关。MR-proADM 与夜间收缩压 (SBP) 呈正相关。在纵向分析中,基线 MR-proADM 与 3 年内办公室 SBP 和脉压 (PP) 的增加相关[β(95% CI):分别为 8.2(0.4,15.9)和 β(95% CI):6.4(0.3,12.4)],但与脉搏波速度、RRI 和 AI 的变化无关:结论:MR-proADM 与 DBP 的横断面负相关与 ADM 的已知血管扩张特性相符。基线 MR-proADM 与夜间 SBP 之间的正相关可能反映了内皮功能障碍,据信这是夜间高血压发病机制的一部分。较高的基线MR-proADM水平与3年随访时SBP和PP的增加有关,这表明ADM水平可能是心血管风险的标志物。
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引用次数: 0
Relationship between systolic blood pressure and renal function on clinical outcomes in patients with atrial fibrillation: a report from the prospective AF-GEN-UK Registry. 收缩压和肾功能与心房颤动患者临床结局的关系:英国前瞻性心房颤动-GEN 登记报告。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1097/HJH.0000000000003856
Alena Shantsila, Gregory Y H Lip, Deirdre A Lane

Background: Blood pressure (BP) extremes and renal (dys)function contribute to poor outcomes in patients with atrial fibrillation (AF). Using data from the prospective AF-GEN-UK study, we investigated the effect of systolic BP and interaction with renal function for prognostication.

Methods: Baseline systolic BP (SBP) values were recorded for 1580 patients (mean [SD] age 71 [11] years, 60% male) and categorized as follows: 120-129 mmHg ( n  = 289, reference group) <110 mmHg ( n  = 165), 110-119 mmHg, ( n  = 254), 130-139 mmHg ( n  = 321), 140-159 mmHg ( n  = 385) and ≥160 mmHg ( n  = 166). Cox regression analysis, adjusted for age, oral anticoagulation (OAC) and CHA 2 DS 2 -VASc score established the impact of SBP, renal function and their interaction on 1-year outcomes. SBP groups were compared using ANOVA and chi-square tests.

Results: OAC use was 84% and similar across SBP groups. Renal dysfunction [estimated baseline glomerular filtration rate (eGFR) < 60 ml/min] was present in 24%, with significantly lower eGFR values in the SBP 110-119 mmHg group. History of heart failure was significantly higher in those with SBP <110 mmHg. SBP <110 mmHg was predictive of all cause-death on univariate [hazard ratio (HR) 2.36, 95% confidence interval (CI) 1.20-4.64] and adjusted (aHR 9.71, 95% CI 1.73-54.5) regression. There was no statistically significant interaction between SBP and eGFR, no associations of SBP with haemorrhagic or thromboembolic events.

Conclusions: In people with AF, SBP <110 mmHg was independently predictive of all-cause death, with no significant interaction between SBP and renal (dys)function. This may reflect general poor health and/or excessive antihypertensive therapy, which should be avoided.

背景:极端血压(BP)和肾功能(异常)会导致心房颤动(AF)患者预后不良。我们利用前瞻性 AF-GEN-UK 研究的数据,研究了收缩压以及收缩压与肾功能相互作用对预后的影响:方法:记录了 1580 名患者(平均 [SD] 年龄 71 [11] 岁,60% 为男性)的基线收缩压(SBP)值,并将其分类如下:结果:OAC使用率为84%,各SBP组相似。24%的患者存在肾功能障碍[估计基线肾小球滤过率(eGFR)< 60 ml/min],SBP 110-119 mmHg 组的 eGFR 值明显较低。有心力衰竭病史的 SBP 患者明显较多:在房颤患者中,SBP
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引用次数: 0
Task-sharing with community health workers to treat hypertension: a scoping review. 与社区卫生工作者分担治疗高血压的任务:范围界定综述。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-09-18 DOI: 10.1097/HJH.0000000000003834
Yoko Inagaki, Kunihiro Matsushita, Lawrence J Appel, Henry B Perry, Dinesh Neupane

Many studies have implemented and evaluated task-sharing interventions with community health workers (CHWs) to manage hypertension. To identify gaps in research, we conducted a scoping review. We searched original articles published in PubMed and EMBASE between 2010 and 2022 and found 122 articles meeting our inclusion criteria. Only seven articles were from low-income countries (LICs), most of which were qualitative studies or mixed methods studies. In the identified 122 articles, CHWs often performed health education (61.3%) and measured blood pressure (60.4%). Whereas CHWs carried out pharmacological treatment in only three studies. Participant homes (75.0%) were the most common setting for receiving interventions. Our study identified specific needs for future research, specifically, studies in LICs that are experimental in design and that collect relevant qualitative information, and studies in which CHWs do advanced task. In addition, publications of CHW studies should provide a more comprehensive list of intervention features.

许多研究已经实施并评估了与社区卫生工作人员(CHWs)共同管理高血压的任务分担干预措施。为了找出研究空白,我们进行了一次范围界定综述。我们检索了 2010 年至 2022 年间发表在 PubMed 和 EMBASE 上的原创文章,发现 122 篇文章符合我们的纳入标准。只有七篇文章来自低收入国家,其中大部分是定性研究或混合方法研究。在已确定的 122 篇文章中,社区保健工作者通常开展健康教育(61.3%)和测量血压(60.4%)。而只有三项研究中,社区保健员进行了药物治疗。参与者家中(75.0%)是最常见的接受干预的场所。我们的研究确定了未来研究的具体需求,特别是在低收入国家进行的实验性设计研究和收集相关定性信息的研究,以及由社区保健工作者执行高级任务的研究。此外,有关社区保健工作者研究的出版物应提供更全面的干预特点清单。
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引用次数: 0
Baseline characteristics of the first 302 patients included for acute malignant hypertension crisis in the prospective multidisciplinary HAMA cohort. 前瞻性多学科 HAMA 队列中首批 302 名急性恶性高血压危象患者的基线特征。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1097/HJH.0000000000003851
Romain Boulestreau, Aurélien Lorthioir, Hervé Dreau, Alexandre Persu, Antoine Cremer, Pierre-Louis Tharaux, Sébastien Rubin, Benjamin Maier, Mikael Mazighi, Alice Seris, Michel Paques, Sophie Bonnin, Jean Michel Halimi, Stéphane Debeugny, Philippe Gosse

Background: Malignant hypertension has not disappeared and remains the most severe form of hypertension. More than 100 years after its description, many points remain unanswered. Mechanisms, definitions, and optimal treatment are still controversial. In 2019, we decided to launch a prospective multicentre multidisciplinary cohort in France to try to fill these gaps.

Method: This study aimed to describe the baseline characteristics of the first 302 included patients and compared these data to already published cohorts. We included patients with severe hypertension associated with severe hypertensive retinopathy and patients filling the HYP MOD (HYPertension MultiOrgan Damage) definition from a broad range of departments (cardiology, nephrology, neurology intensive care unit, emergency department, internal medicine). We collected clinical, biological, imaging, and target organ damage data at admission, along with social and demographic data. We also recorded diagnostic and therapeutic management, adverse events during hospitalization, and characteristics at discharge.

Results: We enrolled 302 patients in 32 months (105/year) among 40 centres and different specialties. They mainly included young men (68%, mean age 48.7 ± 14.5 years). Target organ damage involved the eye in 86.7% of patients, kidney in 58.6%, heart in 50%, brain in 32.8%, and Thrombotic Microangiopathy stigmata in 15.6%. Patients with severe retinopathy shared characteristics similar to those included in the most important cohorts already published. We also reported several additional subgroups of interest: one-third of our patients were less than 40 years old, one-third were of non-European origin, 14.3% were included through the multiorgan damage definition, without fundus severe injuries, 22.8% were treated without the use of IV therapy, 40.9% had normal or low renin level, and almost all patients were not on antihypertensive therapy at the time of the enrolment.

Conclusion: These preliminary findings already challenge long-standing dogma, raise numerous questions, and provide a solid basis to address them in ancillary studies of the cohort.

恶性高血压并没有消失,仍然是最严重的高血压。恶性高血压被描述 100 多年后,许多问题仍未得到解答。其机制、定义和最佳治疗方法仍存在争议。2019 年,我们决定在法国开展一项前瞻性多中心多学科队列研究,试图填补这些空白。本研究旨在描述首批纳入的 302 名患者的基线特征,并将这些数据与已发表的队列进行比较。我们纳入了重度高血压伴重度高血压视网膜病变患者,以及符合HYP MOD(HYPertension MultiOrgan Damage)定义的患者,这些患者来自多个科室(心脏科、肾脏科、神经内科重症监护室、急诊科、内科)。我们收集了入院时的临床、生物学、影像学和靶器官损伤数据,以及社会和人口统计学数据。我们还记录了诊断和治疗方法、住院期间的不良事件以及出院时的特征。我们在 40 个中心和不同专科招募了 302 名患者,历时 32 个月(105 人/年)。他们主要是年轻男性(68%,平均年龄(48.7 ± 14.5)岁)。86.7%的患者的靶器官受损涉及眼睛,58.6%涉及肾脏,50%涉及心脏,32.8%涉及大脑,15.6%涉及血栓性微血管病。严重视网膜病变患者的特征与已发表的最重要队列中的患者相似。我们还报告了其他几个值得关注的亚组:三分之一的患者年龄小于 40 岁,三分之一的患者为非欧洲血统,14.3% 的患者是根据多器官损伤定义纳入的,没有眼底严重损伤,22.8% 的患者在治疗过程中没有使用静脉注射疗法,40.9% 的患者肾素水平正常或较低,几乎所有患者在入组时都没有使用降压疗法。这些初步研究结果已经挑战了长期以来的教条,提出了许多问题,并为在队列辅助研究中解决这些问题提供了坚实的基础。
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引用次数: 0
Quantification of physiological effect of respiration on automated measurement of blood pressure among normotensive adult individuals. 量化呼吸对正常血压成人血压自动测量的生理影响。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-09-02 DOI: 10.1097/HJH.0000000000003860
Soumyajit Mondal, Kalarab Mukherjee, Ankita Ghosh, Farhad Ahmed, Tandra Ghosh

Background: Accurate blood pressure measurement necessitates meticulous methodology, as even minor variations like speaking or sitting can impact the readings. Additionally, respiration plays a role in blood pressure, exhibiting a dip during inhalation and a subsequent increase during exhalation. However, the influence of breathing patterns, duration, and rate on blood pressure remains largely unexplored.

Methods: In this study, we have attempted to quantify the changes in blood pressure and heart rate (HR) of normotensive individuals while performing predefined respiratory patterns - slow, medium, and fast (respiratory rates of 5, 10, and 20/m, respectively). For each respiratory pattern, age-matched and gender-matched (18-40 years) volunteered normotensive individuals were selected as volunteers. Baseline readings were recorded and each volunteer was randomly allotted a respiratory pattern. The volunteers performed the assigned respiratory pattern while the BP and HR were recorded.

Results: A fall in both SBP and DBP was observed in all three patterns of respiration. There was no inter-pattern difference in the blood pressure change. A novel finding in our study was a trend of respiratory rate and HR - the change in HR linearly increased with a rise in respiratory rate difference. We also proposed a linear regression equation for this increase in HR with the increase in respiratory rate which was statistically significant.

Conclusion: The findings suggest the decline in blood pressure is independent of the respiratory pattern employed. The study also demonstrates that the HR is a linear function of respiratory rate.

背景:精确测量血压必须采用细致的方法,因为即使是说话或坐姿等细微变化也会影响读数。此外,呼吸对血压也有影响,吸气时血压下降,呼气时血压上升。然而,呼吸模式、持续时间和频率对血压的影响在很大程度上仍未得到研究:在这项研究中,我们试图量化血压正常的人在进行预定呼吸模式--慢速、中速和快速(呼吸频率分别为 5、10 和 20/m)时的血压和心率(HR)变化。针对每种呼吸模式,均选择年龄和性别匹配(18-40 岁)的正常血压志愿者作为志愿者。记录基线读数后,随机为每位志愿者分配一种呼吸模式。在记录血压和心率的同时,志愿者执行指定的呼吸模式:结果:在所有三种呼吸模式中均观察到 SBP 和 DBP 下降。不同模式之间的血压变化没有差异。我们研究的一个新发现是呼吸频率和心率的变化趋势--心率的变化随着呼吸频率差异的增加而线性增加。我们还提出了一个线性回归方程,用于解释心率随呼吸频率增加而增加的情况,该方程在统计学上具有显著意义:研究结果表明,血压下降与采用的呼吸模式无关。研究还表明,心率是呼吸频率的线性函数。
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引用次数: 0
Recreational beach tennis training reduces ambulatory blood pressure in adults with hypertension: a randomized clinical trial. 休闲沙滩网球训练可降低成人高血压患者的流动血压:随机临床试验。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1097/HJH.0000000000003850
Rodrigo Ferrari, Leandro de Oliveira Carpes, Lucas Betti Domingues, Vinícius Mallmann Schneider, Rodrigo Leal, Hirofumi Tanaka, Nathalia Jung

Objective: To determine the effect of 12 weeks of beach tennis training on 24-h ambulatory blood pressure in adults with essential hypertension.

Methods: This was a randomized, single-blinded, two-arm, parallel superiority trial. Forty-two participants aged 35-65 years with a previous diagnosis of hypertension were randomized into 12 weeks of beach tennis training group (two sessions per week lasting 45-60 min) or a nonexercising control group. Ambulatory 24 h (primary outcome) and office blood pressure, heart rate at rest, cardiorespiratory fitness, and muscle strength were assessed at baseline and after the intervention period. Generalized estimating equation analyses were employed to examine the main effects of the interventions.

Results: In the beach tennis group, night-time systolic (-9 mmHg, P  = 0.023), diastolic (-4 mmHg, P  = 0.026), and mean arterial pressure (-7 mmHg, P  = 0.023) decreased after 12 weeks of training. The office SBP/DBP (-6 mmHg, P  = 0.016/-6 mmHg, P  = 0.001) also decreased in the beach tennis group. Heart rate at rest decreased in the beach tennis group (-4 bpm, P  = 0.012) but increased in the control group (6 bpm, P  = 0.005). The lower and upper limb muscle strength increased in the beach tennis group after training. However, no such changes were observed in the control group.

Conclusion: A 12-week recreational beach tennis training significantly reduced office and ambulatory BP among untrained adults with essential hypertension. Additionally, participation in this sport has led to improvements in physical fitness and overall cardiovascular risk profiles.This clinical trial was registered at Clinicaltrials.gov (NCT03909321).

目的确定为期 12 周的沙滩网球训练对成人原发性高血压患者 24 小时动态血压的影响:这是一项随机、单盲、双臂、平行优势试验。42名年龄在35-65岁之间、曾被诊断患有高血压的参与者被随机分为为期12周的沙滩网球训练组(每周两次,每次45-60分钟)或非运动对照组。在基线期和干预期结束后,对 24 小时动态血压(主要结果)和办公室血压、休息时的心率、心肺功能和肌肉力量进行评估。采用广义估计方程分析来检验干预措施的主要效果:结果:在沙滩网球组,训练 12 周后,夜间收缩压(-9 mmHg,P = 0.023)、舒张压(-4 mmHg,P = 0.026)和平均动脉压(-7 mmHg,P = 0.023)均有所下降。沙滩网球组的办公室 SBP/DBP(-6 mmHg,P = 0.016/-6 mmHg,P = 0.001)也有所下降。沙滩网球组休息时的心率下降(-4 bpm,P = 0.012),而对照组则上升(6 bpm,P = 0.005)。训练后,沙滩网球组的下肢和上肢肌肉力量有所增加。结论:结论:为期 12 周的娱乐性沙滩网球训练可显著降低未经训练的成人原发性高血压患者的办公室血压和流动血压。该临床试验已在 Clinicaltrials.gov 上注册(NCT03909321)。
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引用次数: 0
Abnormal brain-heart electrophysiology in mild and severe orthostatic hypotension. 轻度和重度正张性低血压的脑心电生理学异常。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI: 10.1097/HJH.0000000000003838
Yingzhe Cheng, Peilin Huang, Lin Lin, Jiejun Zhang, Yahui Cheng, Jiahao Zheng, Yanping Wang, Xiaodong Pan

Introduction: This study investigated the changes in cardiocerebral electrophysiology in patients with mild orthostatic hypotension (MOH) and severe orthostatic hypotension (SOH) and their relationship with the severity of orthostatic hypotension, psychiatric symptoms, and cognitive dysfunction.

Methods: This study included 72 nonorthostatic hypotension (NOH), 17 with MOH, and 11 with SOH. Seated resting-state heart rate variability (HRV) and quantitative electroencephalogram parameters were synchronized and recorded. HRV measures in the time and frequency domains were analyzed, along with the peak frequency and power of the brain waves.

Results: Abnormal neuronal activity was found in FP1 in patients with MOH, whereas it was more widespread in FP1, FP2, and O2 in patients with SOH ( P  < 0.05). Cardiac and cerebral electrophysiological abnormalities were significantly associated with orthostatic hypotension severity, psychiatric symptoms, and cognitive dysfunction.

Conclusion: Abnormal EEG activity in patients are mainly manifested in the prefrontal and occipital lobes, especially in patients with SOH. These results may help patients to better understand the mechanisms underlying orthostatic hypotension severity and psychiatric and cognitive impairment in orthostatic hypotension.

简介本研究探讨了轻度正张力性低血压(MOH)和重度正张力性低血压(SOH)患者的心脑电生理学变化及其与正张力性低血压严重程度、精神症状和认知功能障碍的关系:这项研究包括 72 名非正张性低血压(NOH)患者、17 名 MOH 患者和 11 名 SOH 患者。对坐位静息状态心率变异性(HRV)和定量脑电图参数进行了同步记录。对时域和频域的心率变异测量值以及脑电波的峰值频率和功率进行了分析:结果:在 MOH 患者的 FP1 中发现了异常的神经元活动,而在 SOH 患者的 FP1、FP2 和 O2 中则发现了更广泛的异常活动:患者的异常脑电活动主要表现在前额叶和枕叶,尤其是在 SOH 患者中。这些结果可能有助于患者更好地了解正性低血压严重程度以及正性低血压的精神和认知障碍的内在机制。
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引用次数: 0
Serum neutrophil gelatinase-associated lipocalin and cystatin C is associated with blood pressure in ex-preterm children and adolescents. 血清中性粒细胞明胶酶相关脂褐素和胱抑素 C 与早产儿和青少年的血压有关。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI: 10.1097/HJH.0000000000003868
Athanasia Chainoglou, Kosmas Sarafidis, Anna Taparkou, Evangelia Farmaki, Katerina Chrysaidou, Dimos Gidaris, Konstantinos Kollios, Vasilios Kotsis, Stella Stabouli

Background: As preterm birth is a risk factor for hypertension (HTN), biomarkers for early prediction of HTN in childhood is an emerging need. The aims of the study were to evaluate serum biomarkers in ex-preterm children and examine for associations with office peripheral and central SBP (cSBP), ambulatory BP parameters and pulse wave velocity (PWV).

Methods: This case-control study included children and adolescents born prematurely (ex-preterms) and at full term (controls). All participants underwent office and ambulatory BP monitoring, assessment of cSBP, PWV and serum biomarkers at the same visit. Neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-2, metalloproteinase-9 (MMP-2, MMP-9) and Cystatin C (CysC) were measured using ELISA.

Results: The study population included 52 ex-preterm individuals and 26 controls. Mean age was 10.7 ± 3.6 years. NGAL, MMP-2, MMP-9, and CysC levels were similar between the ex-preterm and the control group. In the ex-preterm group, NGAL is associated with office SBP z score ( β  = 1.007, 95% CI 1.001-0.014, P  = 0.049), CysC with office DBP z score ( β  = 1.003, 95% CI 1.001-0.005, P  = 0.018) and cSBP z score ( β  = 1.003, 95% CI 1.001-0.005, P  = 0.006) independently of age, sex and BMI z score. Among ex-preterm children and adolescents 17% had ambulatory HTN and 31% had white-coat HTN. NGAL levels were higher in ex-preterm children with WCH compared with children with normal BP [57.9 (IQR 50.8) versus 34.6 (IQR 46.2)], P  = 0.018].

Conclusion: WCH is common in ex-preterm children and adolescents and is associated with higher NGAL levels and CysC presents positive association with cSBP. The findings in this study provides preliminary evidence that NGAL and CysC may have a role in predicting the risk of developing hypertension later in life. Further studies are warranted.

背景:早产是高血压(HTN)的一个危险因素,因此需要生物标志物对儿童期高血压进行早期预测。本研究的目的是评估早产儿的血清生物标志物,并研究其与办公室外周和中心血压(cSBP)、非卧床血压参数和脉搏波速度(PWV)之间的关联:这项病例对照研究包括早产儿童和青少年(早产儿)以及足月儿(对照组)。所有参与者均接受了诊室和非卧床血压监测、cSBP、脉搏波速度和血清生物标记物评估。采用酶联免疫吸附法测定了中性粒细胞明胶酶相关脂联素(NGAL)、基质金属蛋白酶-2、金属蛋白酶-9(MMP-2、MMP-9)和胱抑素C(CysC):研究对象包括 52 名早产儿和 26 名对照组。平均年龄为 10.7 ± 3.6 岁。早产儿和对照组的 NGAL、MMP-2、MMP-9 和 CysC 水平相似。在前早产儿组中,NGAL与诊室SBP z评分(β = 1.007,95% CI 1.001-0.014,P = 0.049)相关,CysC与诊室DBP z评分(β = 1.003,95% CI 1.001-0.005,P = 0.018)和cSBP z评分(β = 1.003,95% CI 1.001-0.005,P = 0.006)相关,与年龄、性别和BMI z评分无关。在产前儿童和青少年中,17%患有非卧床性高血压,31%患有白大衣性高血压。与血压正常的儿童相比,患有 WCH 的早产儿的 NGAL 水平更高[57.9(IQR 50.8)对 34.6(IQR 46.2)],P = 0.018]:WCH在早产儿和青少年中很常见,与较高的NGAL水平有关,CysC与cSBP呈正相关。本研究的结果提供了初步证据,表明 NGAL 和 CysC 可能在预测日后罹患高血压的风险方面发挥作用。还需要进一步研究。
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引用次数: 0
The impact of the COVID-19 pandemic on blood pressure control in patients with treated hypertension-results of the European Society of Hypertension Study (ESH ABPM COVID-19 Study). COVID-19 大流行对接受治疗的高血压患者血压控制的影响--欧洲高血压学会研究(ESH ABPM COVID-19 研究)结果。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1097/HJH.0000000000003752
Wiktoria Wojciechowska, Marek Rajzer, Reinhold Kreutz, Thomas Weber, Michael Bursztyn, Alexandre Persu, George Stergiou, Gianfranco Parati, Grzegorz Bilo, Agnieszka Pac, Guido Grassi, Giuseppe Mancia, Andrzej Januszewicz, Marzena Chrostowska, Krzysztof Narkiewicz, Andżelina Dubiela, Michaelis Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos, Jean-Baptiste de Freminville, Michel Azizi, Pedro Guimarães Cunha, Jacek Lewandowski, Jakub Strzelczyk, Gregoire Wuerzner, Maria Gosk-Przybyłek, Elżbieta Szwench-Pietrasz, Aleksander Prejbisz, Patricia Van der Niepen, Thomas Kahan, Andreas Jekell, Jonas Spaak, Konstantinos Tsioufis, Georg Ehret, Adrian Doroszko, Piotr Kubalski, Jorge Polonia, Katarzyna Styczkiewicz, Marek Styczkiewicz, Stanisław Mazur, Franco Veglio, Franco Rabbia, Elisabetta Eula, Fernando Jaen Águila, Riccardo Sarzani, Francesco Spannella, Zoltan Jarai, Dimitrios Papadopoulos, Marilucy Lopez-Sublet, Aleksandra Ostrowska, Charalampos Grassos, Ioannis Kahrimanidis, Gkaliagkousi Eugenia, Triantafyllou Areti, Grodzicki Tomasz, Wizner Barbara, Seweryn Aleksandra, Moczulska Beata, Ntineri Angeliki, Nicolas Roberto Robles, Jiri Widmiski, Edyta Zbroch

Background: We aimed to determine the influence of coronavirus disease 2019 (COVID-19) pandemic on blood pressure (BP) control assessed by ambulatory blood pressure monitoring (ABPM).

Methods: Office BP and ABPM data from two visits conducted within a 9-15 months interval were collected from patients treated for hypertension. In the prepandemic group, both visits took place before, while in the pandemic group, Visit-1 was done before and Visit-2 during the pandemic period.

Results: Of 1811 collected patients 191 were excluded because they did not meet the required ABPM time frames. Thus, the study comprised 704 patients from the pandemic and 916 from the prepandemic group. Groups did not differ in sex, age, duration of hypertension, frequency of first line antihypertensive drug use and mean 24 h BP on Visit-1. The prevalence of sustained uncontrolled hypertension was similar in both groups. On Visit-2 mean 24 h BP, daytime and nighttime systolic BP and diastolic BP were higher in the pandemic compared to the prepandemic group ( P  < 0.034). The prevalence of sustained uncontrolled hypertension on Visit-2 was higher in the pandemic than in the prepandemic group [0.29 (95% confidence interval (95% CI): 0.26-0.33) vs. 0.25 (95% CI: 0.22-0.28), P  < 0.037]. In multivariable adjusted analyses a significant difference in BP visit-to-visit change was observed, with a more profound decline in BP between visits in the prepandemic group.

Conclusions: This study using ABPM indicates a negative impact of the COVID-19 pandemic on BP control. It emphasizes the need of developing strategies to maintain BP control during a pandemic such as the one induced by COVID-19.

背景:我们旨在确定冠状病毒病 2019(COVID-19)大流行对非卧床血压监测(ABPM)评估的血压控制的影响:我们旨在确定冠状病毒病 2019(COVID-19)大流行对非卧床血压监测(ABPM)评估的血压(BP)控制的影响:收集高血压患者在 9-15 个月内两次就诊时的诊室血压和 ABPM 数据。在大流行前组,两次就诊均在大流行前进行,而在大流行组,第一次就诊在大流行前进行,第二次就诊在大流行期间进行:结果:在收集到的 1811 名患者中,有 191 人因不符合规定的 ABPM 时间框架而被排除在外。因此,研究包括大流行组的 704 名患者和大流行前组的 916 名患者。两组患者在性别、年龄、高血压持续时间、一线抗高血压药物使用频率和访问-1时的平均24小时血压方面没有差异。两组持续未控制的高血压发病率相似。第 2 次就诊时,大流行组的 24 小时平均血压、日间和夜间收缩压和舒张压均高于大流行前组(P 结论:大流行前组的 24 小时平均血压、日间和夜间收缩压和舒张压均高于大流行前组(P):这项使用 ABPM 的研究表明,COVID-19 大流行对血压控制有负面影响。它强调了在 COVID-19 引起的大流行期间制定保持血压控制策略的必要性。
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引用次数: 0
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Journal of Hypertension
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