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Paternal alcohol exposure affected offspring mesenteric artery via ROS-Cacna1c and DNA hypomethylation. 父亲酒精暴露通过ROS-Cacna1c和DNA低甲基化影响子代肠系膜动脉。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1097/HJH.0000000000003947
Yun He, Ze Zhang, Qiutong Zheng, Hongyu Su, Mingxing Liu, Xueyi Chen, Linglu Qi, Yumeng Zhang, Zhice Xu, Jiaqi Tang

Background: Paternal preconception alcohol exposure affects fetal development; however, it is largely unknown about the influences on offspring vasculature and mechanisms.

Methods: Offspring born form paternal rats treated with alcohol or water before pregnant was raised until 3 months of age. Vessel tone of mesenteric arteries was detected using myograph system; whole-cell calcium channel current in smooth muscle cells was tested using patch-clamp; molecule expressions were detected with real-time PCR, western blotting, and Dihydroethidium (DHE); DNA methylations were determined using targeted bisulfate sequencing assay. Following 5-aza-2'-deoxycytidine incubation, vessel tone in offspring mesenteric artery and Cacna1c expression in A7r5 was tested.

Results: When comparing with the control, stress-strain curve was left-shifted in alcohol. There was lower incremental distensibility and endothelium-dependent dilation associated with endothelial nitric oxide synthase. Agonists-induced constrictions were greater in alcohol offspring than that in control, associated with higher expression of AT1R, Cacna1c, and reactive oxygen species (ROS). Baseline and Ang II-stimulated calcium channel currents were higher in alcohol group. Tempol and apocynin could restore Ang II-increased constriction and calcium channel current in alcohol offspring. When comparing with the control, there was lower DNA methylation of Cacna1c promotor in alcohol offspring mesenteric artery and in paternal sperm. 5-aza-2'-deoxycytidine increased contraction in control offspring mesenteric artery and Cacna1c expression in A7r5.

Conclusion: Paternal preconception alcohol exposure-affected offspring mesenteric artery was via ROS-Cacna1c. Abnormal offspring vascular functions might be inherited via DNA hypomethylation of Cacna1c promotor from paternal sperm exposed to alcohol. These data gained provided important clues for cardiovascular disorders at germ cell origin.

背景:父亲孕前酒精暴露影响胎儿发育;然而,对后代脉管系统的影响及其机制尚不清楚。方法:将怀孕前用酒精或水处理的母鼠所生的子代饲养至3月龄。肌图系统检测肠系膜动脉血管张力;膜片钳法检测平滑肌细胞全细胞钙通道电流;采用实时荧光定量PCR、western blotting和双氢乙啶(DHE)检测分子表达;采用靶向硫酸氢盐测序法测定DNA甲基化。5-aza-2'-脱氧胞苷孵育后,检测子代肠系膜动脉血管张力和A7r5中Cacna1c的表达。结果:与对照组相比,酒精中应力-应变曲线左移。内皮型一氧化氮合酶有较低的增量扩张性和内皮依赖性扩张性。酒精后代中激动剂诱导的收缩比对照组更大,与AT1R、Cacna1c和活性氧(ROS)的高表达有关。酒精组基线和angii刺激的钙通道电流较高。天麻酚和罗布麻素可恢复酒精后代Ang ii -升高的收缩和钙通道电流。与对照组相比,酒精后代肠系膜动脉和父亲精子中Cacna1c启动子的DNA甲基化水平较低。5-aza-2'-脱氧胞苷增加了对照子代肠系膜动脉收缩和A7r5中Cacna1c的表达。结论:父亲孕前酒精暴露通过ROS-Cacna1c影响子代肠系膜动脉。后代血管功能异常可能是通过暴露于酒精的父亲精子中Cacna1c启动子的DNA低甲基化遗传的。这些数据为生殖细胞起源的心血管疾病提供了重要线索。
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引用次数: 0
Beat-to-beat variability of aortic pulse wave velocity: implications for aortic stiffness measurements. 主动脉脉搏波速度的搏动变异性:对主动脉硬度测量的影响。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1097/HJH.0000000000003935
Alessandro Giudici, Andrea Grillo, Filippo Scalise, Koen D Reesink, Tammo Delhaas, Paolo Salvi, Bart Spronck, Gianfranco Parati

Objectives: Aortic pulse wave velocity (aPWV) predicts cardiovascular risk. Being the reference method for aortic stiffness evaluation, invasive aPWV is also recommended for validation of noninvasive devices. Because of intrinsic haemodynamic variability and processing issues, aPWV shows beat-to-beat variability. We aimed to quantify this variability and evaluate its implications for the reliability and use of aPWV as reference in validation and clinical application studies.

Methods: The study included n  = 84 patients, in whom two datasets of invasive data were recorded: 1) simultaneous ascending aorta and iliac pressure acquisitions using a dual-tip intra-aortic catheter, and 2) an additional ascending aorta pressure acquisition. By combining the iliac and ascending aorta pressure recordings from the first and second acquisitions, respectively, we evaluated how a sequential acquisition protocol affects variability. We compared three pressure waveform foot identification methods to investigate the effect of data processing on variability. Furthermore, we estimated how averaging over nbeats consecutive heartbeats affects the standard deviation (SD) of such nbeats -averaged estimate of aPWV.

Results: The simultaneously acquired invasive aPWV showed a 5% beat-to-beat SD (variability), with small but significant differences between foot identification methods. The sequential acquisition protocol doubled aPWV variability compared to simultaneous acquisition. However, because averaging had a much stronger effect on sequentially measured aPWV, the two acquisition protocols yielded comparable variabilities at nbeats  = 10 (2% vs. 3%).

Conclusions: Our study suggests that, independently from the acquisition protocol and data processing, the intrinsic beat-to-beat variability of aPWV becomes manageable when aPWV values of at least ten heartbeats are averaged.

目的:主动脉脉波速度(aPWV)预测心血管风险。作为主动脉硬度评估的参考方法,有创aPWV也被推荐用于无创器械的验证。由于固有的血流动力学变异性和处理问题,aPWV表现出搏动间的变异性。我们的目的是量化这种变异性,并评估其对aPWV的可靠性和使用的影响,作为验证和临床应用研究的参考。方法:研究纳入n = 84例患者,记录两组有创数据:1)使用双尖端主动脉内导管同时获得升主动脉和髂动脉压力,2)额外获得升主动脉压力。通过结合第一次和第二次采集的髂动脉和升主动脉压力记录,我们评估了顺序采集方案如何影响变异性。我们比较了三种压力波形脚识别方法,以研究数据处理对变异性的影响。此外,我们估计了超过nbeat连续心跳的平均如何影响这种nbeat -average估计aPWV的标准差(SD)。结果:同时获得的有创aPWV显示出5%的节拍间SD(变异性),不同足部识别方法间差异虽小但显著。与同时采集相比,顺序采集协议使aPWV变异性增加了一倍。然而,由于平均对顺序测量的aPWV有更强的影响,两种采集方案在nbeats = 10时产生了相当的变化(2%对3%)。结论:我们的研究表明,独立于采集方案和数据处理,当平均至少10次心跳的aPWV值时,aPWV的内在搏动变异性变得可控。
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引用次数: 0
Prevalence and correlates of uncontrolled hypertension and cardiovascular morbidity among patients with hypertension at the largest tertiary care hospital in Sri Lanka. 斯里兰卡最大的三级保健医院高血压患者中未控制的高血压和心血管发病率的患病率及其相关因素。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI: 10.1097/HJH.0000000000003952
Priyanga Ranasinghe, Minura Manchanayake, Thilina Perera, Sandamini Liyanage, David J Webb

Introduction: Hypertension is the leading preventable cause of cardiovascular morbidity and mortality globally, with a disproportionate impact on low-income and middle-income countries like Sri Lanka. Effective blood pressure (BP) control improves outcomes in patients with hypertension. This study aimed to assess the prevalence of uncontrolled hypertension, and its correlates among Sri Lankan patients with hypertension in clinic settings.

Methods: A cross-sectional study was done at the largest tertiary care hospital in Sri Lanka and patients with hypertension presenting to its medical clinics over a 6-month period were recruited. An interviewer-administered questionnaire captured sociodemographic, morbidity, and medication details from records. BP measurements were taken following standard guidelines with OMRON-X7 BP monitors. Multivariate logistic regression was used to identify significant associations ( P  < 0.05).

Results: Among 600 patients (mean age 64 ± 9 years, 43% men), 55% had uncontrolled hypertension. Most (62%) were on 1 or 2 antihypertensives, primarily renin-angiotensin blockers (91%), with minimal (<10%) thiazide use. Uncontrolled hypertension was less common among furosemide (10.5%) and spironolactone (21.5%) users but frequent among those on alpha-blockers (16.3%). Coronary artery disease (58%), heart failure (9%), and stroke (17%) were more common in men and those with longstanding hypertension. Beta-blockers were favoured in those with cardiac comorbidities, and dihydropyridines in those with stroke. Potential treatment resistance, seen in 11%, was associated with increased cardiac morbidity, while sociodemographic factors and family history had no significant impact on BP control or cardiovascular morbidity.

Conclusion: Uncontrolled hypertension and cardiovascular morbidity were highly prevalent. The data suggest the need for optimized antihypertensive regimens, with reduced use of alpha-blockers and early and prioritized incorporation of diuretics.

导言:高血压是全球心血管发病率和死亡率的主要可预防原因,对斯里兰卡等低收入和中等收入国家的影响尤为严重。有效控制血压(BP)可改善高血压患者的预后。本研究旨在评估斯里兰卡临床高血压患者中未控制的高血压患病率及其相关因素。方法:在斯里兰卡最大的三级医院进行了一项横断面研究,招募了6个月以上就诊的高血压患者。访谈者管理的问卷从记录中获取社会人口统计、发病率和药物细节。使用OMRON-X7血压监测仪按照标准指南进行血压测量。结果:600例患者(平均年龄64±9岁,43%为男性)中,55%的患者高血压未得到控制。大多数(62%)服用1或2种抗高血压药物,主要是肾素-血管紧张素阻滞剂(91%),很少(结论:未控制的高血压和心血管发病率非常普遍)。这些数据表明,需要优化降压方案,减少α -受体阻滞剂的使用,早期优先使用利尿剂。
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引用次数: 0
Synergistic effect of anemia and obstructive sleep apnea on hypertension: National Health and Nutrition Examination Survey 2015-2018. 贫血和阻塞性睡眠呼吸暂停对高血压的协同作用:2015-2018年全国健康与营养调查
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-04-01 Epub Date: 2024-12-11 DOI: 10.1097/HJH.0000000000003939
Jiajia Yao, Xi He, Han Wang, Anzi Wang, Lin Zhen

Objective: Anemia, obstructive sleep apnea (OSA), and hypertension are common social health problems. They are interconnected. This study assessed the independent association of anemia and OSA with hypertension and the interaction between anemia and OSA on hypertension in the US population.

Methods: Data used by this retrospective study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2015-2018. The relative excess risk due to interaction (RERI), weighted logistic regression, and the attributable proportion due to interaction (AP) were used to investigate the interaction above. Its impact was also assessed via subgroup analysis by gender, age, race, diabetes, smoking, alcohol use, education, and marital status.

Results: After covariate adjustment in 6949 eligible observers, it was found that compared with non-OSA patients, OSA patients were at higher risk of hypertension [odds ratio (OR) = 1.254, 95% confidence interval (CI) 1.099-1.432, P  < 0.001). Meanwhile, OSA and anemia had a potential synergistic effect on the incidence of the disease (OR = 1.705, 95% CI: 1.390-2.091, P  < 0.01): the RERI was 0.371, and the AP was 0.218. In addition, such effect was observed in the subgroup of other race (AP = 0.48), the nondrinking subgroup (AP = 2.50), the subgroup graduating from high school or above (AP = 0.28), the unmarried subgroup (AP = 0.4), the subgroup without diabetes (AP = 0.24), and the drinking subgroup (AP = 0.41).

Conclusion: Anemia and OSA had a potential synergistic effect on hypertension. Their relationship needs to be further elucidated by a further study.

目的:贫血、阻塞性睡眠呼吸暂停(OSA)和高血压是常见的社会健康问题。它们是相互联系的。本研究评估了美国人群中贫血和OSA与高血压的独立关联,以及贫血和OSA对高血压的相互作用。方法:本回顾性研究的数据来自2015-2018年国家健康与营养检查调查(NHANES)。采用相互作用的相对超额风险(rei)、加权逻辑回归和相互作用的归因比例(AP)来研究上述相互作用。还通过性别、年龄、种族、糖尿病、吸烟、饮酒、教育和婚姻状况等亚组分析来评估其影响。结果:6949名符合条件的观察者经协变量调整后发现,与非OSA患者相比,OSA患者发生高血压的风险更高[优势比(OR) = 1.254, 95%可信区间(CI) 1.099 ~ 1.432, P]。结论:贫血与OSA对高血压有潜在的协同作用。它们之间的关系需要进一步的研究来进一步阐明。
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引用次数: 0
Blood pressure measurement at kiosks in public spaces: systematic review and consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability endorsed by the International Society of Hypertension and the World Hypertension League.
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1097/HJH.0000000000003965
George S Stergiou, Konstantinos G Kyriakoulis, Anastasios Kollias, Richard J McManus, Ariadni Menti, Gianfranco Parati, Aletta E Schutte, Jiguang Wang, Kei Asayama, Roland Asmar, Grzegorz Bilo, Niamh Chapman, Takeshi Fujiwara, Geoffrey Head, Nadia Kahn, Kazuomi Kario, Yan Li, Efstathios Manios, Dimitrios Mariglis, Anastasia S Mihailidou, Paul Muntner, Martin Myers, Teemu Niiranen, Takayoshi Ohkubo, Stefano Omboni, Athanasios Protogerou, Francesca Saladini, James Sharman, Daichi Shimbo, Alejandro De La Sierra, Paolo Palatini

Kiosk devices for unsupervised self-measurement of blood pressure (BP) are being used in public spaces and healthcare settings in several countries. This statement by the European Society of Hypertension (ESH) Working Group on BP Monitoring and Cardiovascular Variability provides a review of the published evidence on kiosk BP devices and consensus recommendations for their requirements and clinical use. A systematic literature search identified 54 relevant studies. Kiosk BP measurements appeared to be close to office BP [mean difference systolic 0.2 mmHg (95% confidence intervals -1.3 to 1.8); diastolic -0.4 mmHg (-3.5 to 2.7)], and higher than daytime ambulatory and home BP [mean difference 6.0 mmHg (1.6-10.4)/5.0 (2-8) and 8.1 mmHg (-2.6 to 18.9)/0.2 (-9.6 to 10.0), respectively]. Randomized or observational studies using kiosk BP measurements for hypertension screening or for assessing hypertension control were also included, as well as studies investigating users' and healthcare professionals' opinions, acceptability, and perspectives regarding kiosk BP measurements, and validation studies of kiosk BP devices. These studies had considerable heterogeneity in design, setting, methodology, measurement protocol, and sample size. Thus, at present, the clinical utility of kiosk BP measurements is uncertain. This ESH consensus statement acknowledges the potential of kiosk BP measurement as an emerging method for unsupervised self-measurement in the context of opportunistic screening for hypertension in apparently healthy people and the long-term monitoring of people with diagnosed hypertension. Requirements for the design, validation, function, and use of kiosk BP monitors are provided, together with the pending research questions on their optimal implementation in clinical practice.

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引用次数: 0
In defense of β-blockers: a critical role in primary hypertension management.
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1097/HJH.0000000000003945
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam
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引用次数: 0
Abnormal blood pressure response to exercise and ventricular arrhythmias: a suspicious association in athletes. 运动与室性心律失常的异常血压反应:运动员中可疑的关联。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI: 10.1097/HJH.0000000000003936
Giuseppe Di Gioia, Armando Ferrera, Viviana Maestrini, Sara Monosilio, Maria Rosaria Squeo, Erika Lemme, Andrea Serdoz, Federica Mango, Antonio Pelliccia

Introduction: Abnormal blood pressure response to exercise (ABPR) in athletes is considered a risk for incident hypertension, conferring a higher cardiovascular risk profile. We sought to describe the clinical cardiovascular features of athletes with ABPR and, moreover, the relationship of ABPR with occurrence of exercise-induced ventricular ectopic beats (VEBs).

Methods and results: We enrolled 1460 elite athletes (56.1% male; mean age 25.8 ± 5.1 years old), engaged in skills, power, mixed and endurance sport, who underwent clinical examination, transthoracic echocardiogram (TTE) and exercise stress testing. ABPR was defined as >220/85 mmHg in males and >200/80 mmHg in females. ABPR was found in 8% ( n  = 117) of athletes, being older ( P  = 0.049) and presenting higher cardiovascular risk profile (obesity, P  = 0.007; glucose intolerance, P  = 0.043 and familiarity for cardiovascular disease, P  = 0.026). Athletes with ABPR had higher prevalence of exercise-induced VEBs (19.6% vs. 11.9% in normotensive athletes, P  = 0.015). Uncommon VEBs morphology was more frequent in athletes with ABPR (64.7% vs. 19% in the normotensive, P  = 0.0002). Finally, in those with ABPR and VEBs, TTE revealed greater left ventricular end-diastolic diameter indexed ( P  = 0-006), LVEDVi ( P  = 0.017) and LVMi ( P  = 0.04) compared to those without VEBs.

Conclusion: A not small group of elite athletes (8%) presented an exaggerated blood pressure response to exercise and exhibited higher cardiovascular risk profile compared to their normotensive counterparts. Moreover, athletes with ABPR showed higher prevalence of ventricular arrhythmias on effort and the combination of ABPR and ventricular arrhythmias was associated with more pronounced cardiac remodelling.

运动员对运动的异常血压反应(ABPR)被认为是发生高血压的危险因素,具有较高的心血管风险。我们试图描述ABPR运动员的临床心血管特征,此外,ABPR与运动性室性异位搏(VEBs)发生的关系。方法与结果:我们招募了1460名优秀运动员(56.1%为男性;平均年龄25.8±5.1岁),从事技能、力量、混合和耐力运动,接受临床检查、经胸超声心动图(TTE)和运动负荷测试。男性ABPR定义为>220/85 mmHg,女性>200/80 mmHg。8% (n = 117)的运动员存在ABPR,年龄越大(P = 0.049),心血管风险越高(肥胖,P = 0.007;葡萄糖耐受不良(P = 0.043)和心血管疾病熟悉程度(P = 0.026)。ABPR运动员有较高的运动诱发VEBs患病率(19.6% vs. 11.9%, P = 0.015)。异常veb形态在ABPR运动员中更为常见(64.7% vs. 19%, P = 0.0002)。最后,在ABPR和VEBs患者中,TTE显示左心室舒张末期直径指数(P = 0-006)、LVEDVi (P = 0.017)和LVMi (P = 0.04)高于无VEBs患者。结论:与血压正常的运动员相比,不少优秀运动员(8%)对运动表现出夸大的血压反应,并表现出更高的心血管风险。此外,患有ABPR的运动员在努力时室性心律失常的发生率更高,ABPR和室性心律失常的合并与更明显的心脏重构有关。
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引用次数: 0
The relative contribution of hemodynamic parameters to blood pressure decrease in classical orthostatic hypotension. 典型正张力性低血压时血液动力学参数对血压下降的相对贡献。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-03-01 Epub Date: 2024-09-18 DOI: 10.1097/HJH.0000000000003832
Boriana S Gagaouzova, Amber van der Stam, Madeleine Johansson, Ineke A Van Rossum, Fabian I Kerkhof, Robert Reijntjes, Marc van Houwelingen, Roland D Thijs, Artur Fedorowski, J Gert van Dijk

Purpose: We studied the relative contributions of total peripheral resistance (TPR), stroke volume (SV) and heart rate (HR) to low blood pressure in classical orthostatic hypotension (cOH) on group and individual levels.

Methods: We retrospectively analyzed tilt test records from cOH patients and age/sex-matched controls. We quantified relative effects of HR, SV and TPR on mean arterial pressure (MAP) with the log-ratio method. We studied relations of changes of HR, SV or TPR with the change of MAP across patients and variability of contributions of HR, SV and TPR to MAP. We also explored neurogenic vs. nonneurogenic causes.

Results: MAP responded to tilt with a decrease in patients ( n  = 80) and an increase in controls ( n  = 80). A too small TPR-increase contributed most to cOH, followed by a too large SV-decrease; both effects were partially corrected by a larger increase of HR. Only TPR changes consistently affected MAP change in patients and controls. TPR decreased almost exclusively in patients, most in those with severe cOH. Contributions of HR, SV and TPR to MAP did not differ between probable neurogenic and nonneurogenic causes.

Conclusion: HR, SV and TPR all contributed to cOH, with a key role for TPR; a decrease of TPR was almost unique to patients and may be due to hyperventilation. The lack of differences between neurogenic and nonneurogenic causes needs further study.

目的:我们研究了总外周阻力(TPR)、每搏量(SV)和心率(HR)对典型正性低血压(cOH)患者低血压的相对贡献:我们回顾性分析了 cOH 患者和年龄/性别匹配对照组的倾斜试验记录。我们用对数比值法量化了心率、SV 和 TPR 对平均动脉压 (MAP) 的相对影响。我们研究了不同患者的 HR、SV 或 TPR 变化与 MAP 变化之间的关系,以及 HR、SV 和 TPR 对 MAP 影响的变异性。我们还探讨了神经源性与非神经源性原因:患者(n = 80)的 MAP 对倾斜的反应是降低,而对照组(n = 80)则是升高。TPR增加过少对cOH的影响最大,其次是SV减少过多;HR增加过多可部分纠正这两种影响。只有 TPR 的变化会持续影响患者和对照组的 MAP 变化。几乎只有患者的 TPR 才会下降,严重 cOH 患者的 TPR 降幅最大。HR、SV和TPR对MAP的贡献在可能的神经源性原因和非神经源性原因之间没有差异:结论:HR、SV和TPR都对cOH有影响,其中TPR起着关键作用;TPR的降低几乎是患者特有的,可能是由于过度换气造成的。神经源性和非神经源性病因之间缺乏差异,这一点需要进一步研究。
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引用次数: 0
Serum autotaxin positively associates with hypertension in postmenopausal women: a single center study in China. 血清自体表皮生长因子与绝经后妇女的高血压呈正相关:一项在中国进行的单中心研究。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1097/HJH.0000000000003922
Jie Zhang, Jiayi Wang, Xuefeng Zhou, Shurong Chen, Yu Li, Yini Ke, Youming Li, Chaohui Yu, Yi Chen

Aim: Autotaxin is an adipokine involved in metabolic disorders. The aim of the current study was to evaluate serum autotaxin levels in hypertensive postmenopausal women and establish a relationship between autotaxin and other comorbidities in this special group.

Methods: This single-center study included postmenopausal women who received annual health examinations at the First Affiliated Hospital, College of Medicine, Zhejiang University in Zhejiang, China. The metabolic and demographic characteristics of the subjects, including age, sex, height, weight, blood pressure, and biochemical indices, were collected. The serum autotaxin level was measured via ELISA. The Kolmogorov-Smirnov test, Student's t test, Mann-Whitney U test, χ2 test, receiver operating characteristic (ROC) curve analysis, Spearman correlation analysis and multivariate logistic regression analysis were adopted for statistical analysis.

Results: This pilot observational study included 25 hypertensive postmenopausal women and 25 age-matched normotensive controls. Hypertensive patients presented significant metabolic disturbances with greater comorbidities such as nonalcoholic fatty liver disease, obesity, overweight, diabetes, hypertriglyceridemia and hyperuricemia ( P  < 0.05), impaired renal health with higher uric acid levels ( P  < 0.001), and slightly elevated creatinine levels ( P  = 0.156) with lower estimated glomerular filtration rates (eGFRs) ( P  = 0.195). The serum autotaxin level was markedly greater in the hypertensive group (239.0±59.6 ng/ml vs. 192.7 ± 49.0 ng/ml; P  < 0.01) and was positively associated with systolic blood pressure; diastolic blood pressure; and alanine transaminase, triglycerides (TG), creatinine, and uric acid levels and inversely associated with the eGFR ( P  < 0.05) among postmenopausal women. Serum autotaxin levels positively predicted hypertension, with an AU-ROC of 0.750 [95% confidence interval (CI): 0.613-0.888] and a Youden index of 0.480 at a cutoff of 225 ng/ml. In the multivariate logistic regression analysis, after adjustment for demographic and metabolic parameters (including age, BMI, ALT, TB, uric acid, FBG, TG, LDL and creatinine), autotaxin (ATX) remained independently positively correlated with the risk of hypertension [odds ratio: 1.016, 95% CI 1.001-1.031; P  < 0.05).

Conclusions: Among postmenopausal women, the serum autotaxin level is significantly elevated in the hypertensive group compared with age-matched normotensive controls. ATX is related to multiple metabolic disorders and renal health, suggesting that autotaxin has potential as a multiorgan therapeutic target for cardiovascular-metabolic-renal disorders.

目的:自体表皮生长因子是一种参与代谢紊乱的脂肪因子。本研究旨在评估高血压绝经后妇女的血清自体表皮生长因子水平,并确定自体表皮生长因子与这一特殊群体的其他合并症之间的关系:这项单中心研究纳入了在浙江大学医学院附属第一医院接受年度健康检查的绝经后妇女。研究收集了受试者的代谢和人口统计学特征,包括年龄、性别、身高、体重、血压和生化指标。通过酶联免疫吸附法测定血清自体表皮生长因子水平。统计分析采用 Kolmogorov-Smirnov 检验、Student's t 检验、Mann-Whitney U 检验、χ2 检验、接收器操作特征曲线(ROC)分析、Spearman 相关性分析和多变量逻辑回归分析:这项试验性观察研究包括 25 名绝经后高血压妇女和 25 名年龄匹配的正常血压对照组。高血压患者出现了明显的代谢紊乱,合并症较多,如非酒精性脂肪肝、肥胖、超重、糖尿病、高甘油三酯血症和高尿酸血症(P 结论:高血压患者的代谢紊乱和合并症较多,如非酒精性脂肪肝、肥胖、超重、糖尿病、高甘油三酯血症和高尿酸血症(P):在绝经后妇女中,与年龄匹配的正常血压对照组相比,高血压组的血清自体血清素水平明显升高。ATX与多种代谢紊乱和肾脏健康有关,这表明自体表皮生长因子有可能成为心血管-代谢-肾脏疾病的多器官治疗靶点。
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引用次数: 0
Differences in sex and age response to single pill combination based antihypertensive therapy reflecting in blood pressure and arterial stiffness. 反映血压和动脉僵化的单药联合降压疗法的性别和年龄反应差异。
IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-03-01 Epub Date: 2024-11-07 DOI: 10.1097/HJH.0000000000003901
Jana Brguljan Hitij, Zbigniew Gaciong, Dragan Simić, Péter Vajer, Parounak Zelveian, Irina E Chazova, Bojan Jelaković

Objective: There are noticeable sex differences in the treatment response to antihypertensives, with limited data on the response to single pill combinations. The aim of the PRECIOUS trial was to assess the treatment response to perindopril/amlodipine and perindopril/amlodipine/indapamide dual and triple single-pill combination in men and women.

Methods: Four hundred and forty adults with essential hypertension were assessed in the 16-week interventional, open-label, prospective, international, multicentre trial. Based on the previous antihypertensive therapy, patients were assigned to either perindopril/amlodipine 4/5 mg or perindopril/amlodipine/indapamide 4/5/1.25 mg, with the initial dose up-titrated in 4-week intervals in case of uncontrolled blood pressure. An additional analysis was performed for sex- and age-related differences on the blood pressure response and arterial stiffness in men and women aged 35-74 years.

Results: Women achieved better overall blood pressure control in all age groups, except for the 35-44 age group. Women presented higher average 24 h aortic augmentation indexes than men, but had more pronounced decreasing trends. The pulse wave velocity was only age-dependent, with reductions slightly greater in women. Both the aortic augmentation index and pulse wave velocity were significantly decreased in all groups compared to baseline.

Conclusions: The results of the PRECIOUS trial contribute significant data to the expanding body of evidence on sex differences in hypertension, including the aspect of age-related changes during the life course of women. The differences between same-aged men and women tend to be smaller with advancing age, but with a greater treatment response in women in all age groups for all observed blood pressure parameters and arterial stiffness.

Trial registration: ClinicalTrials.gov identifier NCT03738761.

目的:降压药的治疗反应存在明显的性别差异,而单药组合的反应数据有限。PRECIOUS 试验旨在评估男性和女性对培哚普利/氨氯地平和培哚普利/氨氯地平/吲达帕胺双联和三联单药组合的治疗反应:在这项为期 16 周的介入性、开放标签、前瞻性、国际多中心试验中,对 440 名成人原发性高血压患者进行了评估。根据之前的降压治疗情况,患者被分配到培哚普利/氨氯地平 4/5 毫克或培哚普利/氨氯地平/吲达帕胺 4/5/1.25 毫克的治疗方案中,如果血压未得到控制,初始剂量每 4 周上调一次。此外,还对 35-74 岁男性和女性在血压反应和动脉僵化方面的性别和年龄差异进行了分析:结果:除 35-44 岁年龄组外,所有年龄组的女性都能更好地控制血压。女性 24 小时平均主动脉增强指数高于男性,但下降趋势更明显。脉搏波速度只与年龄有关,女性的下降幅度略大。与基线相比,所有组别的主动脉增强指数和脉搏波速度都有显著下降:PRECIOUS试验的结果为不断扩大的高血压性别差异证据库提供了重要数据,包括女性生命过程中与年龄相关的变化。随着年龄的增长,同龄男性和女性之间的差异趋于缩小,但在所有观察到的血压参数和动脉僵化方面,所有年龄组的女性都有更大的治疗反应:试验注册:ClinicalTrials.gov 识别码 NCT03738761。
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引用次数: 0
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Journal of Hypertension
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