{"title":"Editorial for \"High-Fidelity MRI Assessment of Cerebral Perfusion in Healthy Neonates Less Than 1 Week of Age\".","authors":"Masaaki Hori, Kei Nakahara, Masahiro Kobayashi","doi":"10.1002/jmri.29745","DOIUrl":"https://doi.org/10.1002/jmri.29745","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian N Dontchos, Matthew D Phelps, Habib Rahbar, Diana L Lam
Breast MRI is the most sensitive modality for assessing the extent of disease in patients with newly-diagnosed breast cancer because it identifies clinically- and mammographically-occult breast cancers. Though highly sensitive, breast MRI has lower specificity that may result in false positive findings and potential overestimation of disease if additional MRI findings are not biopsied prior to surgery. It had been anticipated that the superior cancer detection rate of pre-treatment MRI would translate to improved immediate (surgical re-excision) and long-term patient outcomes such as breast cancer recurrence and survival rates, but studies have not necessarily supported this assumption. In this review, current recommendations and utilization of breast MRI for pre-treatment local staging of breast cancer will be presented, with an emphasis on specific clinical scenarios for patient selection and its impact on short- and long-term patient clinical outcomes. We will also present new evidence that pre-treatment MRI may support de-escalation of treatment and discuss emerging advanced MRI techniques that may improve diagnostic performance.
{"title":"Pre-Treatment Breast MRI: Clinical Indications, Outcomes, and Future Directions.","authors":"Brian N Dontchos, Matthew D Phelps, Habib Rahbar, Diana L Lam","doi":"10.1002/jmri.29741","DOIUrl":"https://doi.org/10.1002/jmri.29741","url":null,"abstract":"<p><p>Breast MRI is the most sensitive modality for assessing the extent of disease in patients with newly-diagnosed breast cancer because it identifies clinically- and mammographically-occult breast cancers. Though highly sensitive, breast MRI has lower specificity that may result in false positive findings and potential overestimation of disease if additional MRI findings are not biopsied prior to surgery. It had been anticipated that the superior cancer detection rate of pre-treatment MRI would translate to improved immediate (surgical re-excision) and long-term patient outcomes such as breast cancer recurrence and survival rates, but studies have not necessarily supported this assumption. In this review, current recommendations and utilization of breast MRI for pre-treatment local staging of breast cancer will be presented, with an emphasis on specific clinical scenarios for patient selection and its impact on short- and long-term patient clinical outcomes. We will also present new evidence that pre-treatment MRI may support de-escalation of treatment and discuss emerging advanced MRI techniques that may improve diagnostic performance.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alex Diaz, Chelsea Meloche, Mohamed Abdelmotleb, Hamid Chalian, Ana Paula Santos Lima, Luba Frank, Karen Ordovas
The diagnosis of cardiovascular disease in women poses an ongoing challenge due to lack of knowledge about sex differences in the manifestations of cardiovascular disease, since women have been underrepresented in cardiovascular research studies that guide current practice. The purpose of this article is to review a spectrum of cardiovascular disorders which occur exclusively or more frequently in women and to highlight the role that cardiovascular magnetic resonance (MR) plays in diagnosing and prognosticating these disorders. Specifically, this review focuses on cardio-oncologic, ischemic, inflammatory, autoimmune, peri-partum, and genetic manifestations of cardiomyopathy in women. We strive to draw attention to the added diagnostic value provided by cardiac MR, compared against alternative imaging modalities, and propose opportunities for further research on sex differences in imaging and diagnosing cardiovascular diseases. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 3.
{"title":"High Impact Clinical Applications of Cardiac Magnetic Resonance Imaging in Women: A Review.","authors":"Alex Diaz, Chelsea Meloche, Mohamed Abdelmotleb, Hamid Chalian, Ana Paula Santos Lima, Luba Frank, Karen Ordovas","doi":"10.1002/jmri.29736","DOIUrl":"https://doi.org/10.1002/jmri.29736","url":null,"abstract":"<p><p>The diagnosis of cardiovascular disease in women poses an ongoing challenge due to lack of knowledge about sex differences in the manifestations of cardiovascular disease, since women have been underrepresented in cardiovascular research studies that guide current practice. The purpose of this article is to review a spectrum of cardiovascular disorders which occur exclusively or more frequently in women and to highlight the role that cardiovascular magnetic resonance (MR) plays in diagnosing and prognosticating these disorders. Specifically, this review focuses on cardio-oncologic, ischemic, inflammatory, autoimmune, peri-partum, and genetic manifestations of cardiomyopathy in women. We strive to draw attention to the added diagnostic value provided by cardiac MR, compared against alternative imaging modalities, and propose opportunities for further research on sex differences in imaging and diagnosing cardiovascular diseases. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiyi Hu, Dengrong Jiang, Jennifer Shepard, Yuto Uchida, Kenichi Oishi, Wen Shi, Peiying Liu, Doris Lin, Vivek Yedavalli, Aylin Tekes, William Christopher Golden, Hanzhang Lu
<p><strong>Background: </strong>Perfusion imaging of the brain has important clinical applications in detecting neurological abnormalities in neonates. However, such tools have not been available to date. Although arterial-spin-labeling (ASL) MRI is a powerful noninvasive tool to measure perfusion, its application in neonates has encountered obstacles related to low signal-to-noise ratio (SNR), large-vessel contaminations, and lack of technical development studies.</p><p><strong>Purpose: </strong>To systematically develop and optimize ASL perfusion MRI in healthy neonates under 1 week of age.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Thirty-two healthy term neonates (19 female; postnatal age 1.9 ± 0.7 days).</p><p><strong>Field strength/sequence: </strong>3.0 T; T<sub>2</sub>-weighted half-Fourier single-shot turbo-spin-echo (HASTE) imaging, single-delay and multi-delay 3D gradient-and-spin-echo (GRASE) large-vessel-suppression pseudo-continuous ASL (LVS-pCASL).</p><p><strong>Assessment: </strong>Three studies were conducted. First, an LVS-pCASL MRI sequence was developed to suppress large-vessel spurious signals in neonatal pCASL. Second, multiple post-labeling delays (PLDs) LVS-pCASL were employed to simultaneously estimate normative cerebral blood flow (CBF) and arterial transit time (ATT) in neonates. Third, an enhanced background-suppression (BS) scheme was developed to increase the SNR of neonatal pCASL.</p><p><strong>Statistical tests: </strong>Repeated measure analysis-of-variance, paired t-test, spatial intraclass-correlation-coefficient (ICC), and voxel-wise coefficient-of-variation (CoV). P-value <0.05 was considered significant.</p><p><strong>Results: </strong>LVS-pCASL reduced spurious ASL signals, making the CBF images more homogenous and significantly reducing the temporal variation of CBF measurements by 58.0% when compared to the standard pCASL. Multi-PLD ASL yielded ATT and CBF maps showing a longer ATT and lower CBF in the white matter relative to the gray matter. The highest CBF was observed in basal ganglia and thalamus (10.4 ± 1.9 mL/100 g/min). Enhanced BS resulted in significantly higher test-retest reproducibility (ICC = 0.90 ± 0.04, CoV = 8.4 ± 1.2%) when compared to regular BS (ICC = 0.59 ± 0.12, CoV = 23.6 ± 3.8%).</p><p><strong>Data conclusion: </strong>We devised an ASL method that can generate whole-brain CBF images in 4 minutes with a test-retest image ICC of 0.9. This technique holds potential for studying neonatal brain diseases involving perfusion abnormalities.</p><p><strong>Plain language summary: </strong>MR imaging of cerebral blood flow in neonates remains a challenge due to low blood flow rates and confounding factors from large blood vessels. This study systematically developed an advanced MRI technique to enhance the reliability of perfusion measurements in neonates. The proposed method reduced signal artifacts from large blood vessels and improved the signal-to-noi
{"title":"High-Fidelity MRI Assessment of Cerebral Perfusion in Healthy Neonates Less Than 1 Week of Age.","authors":"Zhiyi Hu, Dengrong Jiang, Jennifer Shepard, Yuto Uchida, Kenichi Oishi, Wen Shi, Peiying Liu, Doris Lin, Vivek Yedavalli, Aylin Tekes, William Christopher Golden, Hanzhang Lu","doi":"10.1002/jmri.29740","DOIUrl":"https://doi.org/10.1002/jmri.29740","url":null,"abstract":"<p><strong>Background: </strong>Perfusion imaging of the brain has important clinical applications in detecting neurological abnormalities in neonates. However, such tools have not been available to date. Although arterial-spin-labeling (ASL) MRI is a powerful noninvasive tool to measure perfusion, its application in neonates has encountered obstacles related to low signal-to-noise ratio (SNR), large-vessel contaminations, and lack of technical development studies.</p><p><strong>Purpose: </strong>To systematically develop and optimize ASL perfusion MRI in healthy neonates under 1 week of age.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Thirty-two healthy term neonates (19 female; postnatal age 1.9 ± 0.7 days).</p><p><strong>Field strength/sequence: </strong>3.0 T; T<sub>2</sub>-weighted half-Fourier single-shot turbo-spin-echo (HASTE) imaging, single-delay and multi-delay 3D gradient-and-spin-echo (GRASE) large-vessel-suppression pseudo-continuous ASL (LVS-pCASL).</p><p><strong>Assessment: </strong>Three studies were conducted. First, an LVS-pCASL MRI sequence was developed to suppress large-vessel spurious signals in neonatal pCASL. Second, multiple post-labeling delays (PLDs) LVS-pCASL were employed to simultaneously estimate normative cerebral blood flow (CBF) and arterial transit time (ATT) in neonates. Third, an enhanced background-suppression (BS) scheme was developed to increase the SNR of neonatal pCASL.</p><p><strong>Statistical tests: </strong>Repeated measure analysis-of-variance, paired t-test, spatial intraclass-correlation-coefficient (ICC), and voxel-wise coefficient-of-variation (CoV). P-value <0.05 was considered significant.</p><p><strong>Results: </strong>LVS-pCASL reduced spurious ASL signals, making the CBF images more homogenous and significantly reducing the temporal variation of CBF measurements by 58.0% when compared to the standard pCASL. Multi-PLD ASL yielded ATT and CBF maps showing a longer ATT and lower CBF in the white matter relative to the gray matter. The highest CBF was observed in basal ganglia and thalamus (10.4 ± 1.9 mL/100 g/min). Enhanced BS resulted in significantly higher test-retest reproducibility (ICC = 0.90 ± 0.04, CoV = 8.4 ± 1.2%) when compared to regular BS (ICC = 0.59 ± 0.12, CoV = 23.6 ± 3.8%).</p><p><strong>Data conclusion: </strong>We devised an ASL method that can generate whole-brain CBF images in 4 minutes with a test-retest image ICC of 0.9. This technique holds potential for studying neonatal brain diseases involving perfusion abnormalities.</p><p><strong>Plain language summary: </strong>MR imaging of cerebral blood flow in neonates remains a challenge due to low blood flow rates and confounding factors from large blood vessels. This study systematically developed an advanced MRI technique to enhance the reliability of perfusion measurements in neonates. The proposed method reduced signal artifacts from large blood vessels and improved the signal-to-noi","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Diagnosis of Sacroiliitis Through Semi-Supervised Segmentation and Radiomics Feature Analysis of MRI Images\".","authors":"Eros Montin","doi":"10.1002/jmri.29732","DOIUrl":"https://doi.org/10.1002/jmri.29732","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ming-Lei Li, Ruo-Yang Shi, Jin-Yu Zheng, Jin-Yi Xiang, Ward Hedges, Julia Liang, Jiani Hu, Jie Chen, Lei Zhao, Lian-Ming Wu
<p><strong>Background: </strong>The incremental prognostic value of integrating myocardial cine radiomics into predictive models for major adverse cardiovascular events (MACE) risk in patients with ST-elevation myocardial infarction (STEMI) is unclear.</p><p><strong>Purpose: </strong>To determine if myocardial cine radiomics can improve risk assessment for MACE when combined with clinical information and cardiac MRI parameters in STEMI patients.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Subjects: </strong>One thousand twenty-four STEMI patients (83% male; mean age 59 ± 11 years) from two centers, divided into training (819 patients) and external testing (205 patients) cohorts.</p><p><strong>Field strength/sequence: </strong>3.0 T/balanced steady-state free precession cine, and phase-sensitive inversion recovery sequences.</p><p><strong>Assessment: </strong>The Rad_score was calculated as a weighted sum of independent radiomic variables derived from the logistic regression model, providing a concise representation of their combined prognostic impact. Six risk models were developed, incorporating varying combinations of MRI parameters, clinical variables, and Rad_score to comprehensively evaluate their prognostic performance. A final risk stratification, integrating left ventricular ejection fraction (LVEF), the extent of late gadolinium enhancement (LGE), and Rad_score, was established and compared with one based on LVEF alone.</p><p><strong>Statistical tests: </strong>The prognostic implications of the Rad_score were evaluated using univariable and multivariable Cox proportional hazards models. A P value <0.05 was considered significant.</p><p><strong>Results: </strong>During a median follow-up of 3.1 years, 139 patients (17%) in the training set and 30 patients (15%) in the testing set experienced MACE. Rad_score was identified as a significant risk factor for MACE, with a hazard ratio of 1.46 (1.38-1.55) (P < 0.01) in univariate Cox analysis. The risk stratification reclassified the risk for 33% of the study population in the training set and 34% in the testing set.</p><p><strong>Data conclusion: </strong>Myocardial cine radiomics are associated with MACE risk in STEMI patients and provide incremental improvement in risk stratification when combined with traditional parameters.</p><p><strong>Plain language summary: </strong>The development of radiomics has introduced new perspectives in both the diagnosis and prognosis of cardiovascular diseases. However, the incremental prognostic value of incorporating myocardial cine radiomics into predictive models for major adverse cardiovascular events (MACE) risk in patients with ST-elevation myocardial infarction (STEMI) remains unclear. This study integrates radiomics with traditional clinical parameters and cardiac magnetic resonance imaging (MRI) to evaluate its added value in assessing MACE risk in STEMI patients. The results demonstrate that radiomics is significantly associat
{"title":"Myocardial MRI Cine Radiomics: A Novel Approach to Risk-Stratification for Major Adverse Cardiovascular Events in Patients With ST-Elevation Myocardial Infarction.","authors":"Ming-Lei Li, Ruo-Yang Shi, Jin-Yu Zheng, Jin-Yi Xiang, Ward Hedges, Julia Liang, Jiani Hu, Jie Chen, Lei Zhao, Lian-Ming Wu","doi":"10.1002/jmri.29739","DOIUrl":"https://doi.org/10.1002/jmri.29739","url":null,"abstract":"<p><strong>Background: </strong>The incremental prognostic value of integrating myocardial cine radiomics into predictive models for major adverse cardiovascular events (MACE) risk in patients with ST-elevation myocardial infarction (STEMI) is unclear.</p><p><strong>Purpose: </strong>To determine if myocardial cine radiomics can improve risk assessment for MACE when combined with clinical information and cardiac MRI parameters in STEMI patients.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Subjects: </strong>One thousand twenty-four STEMI patients (83% male; mean age 59 ± 11 years) from two centers, divided into training (819 patients) and external testing (205 patients) cohorts.</p><p><strong>Field strength/sequence: </strong>3.0 T/balanced steady-state free precession cine, and phase-sensitive inversion recovery sequences.</p><p><strong>Assessment: </strong>The Rad_score was calculated as a weighted sum of independent radiomic variables derived from the logistic regression model, providing a concise representation of their combined prognostic impact. Six risk models were developed, incorporating varying combinations of MRI parameters, clinical variables, and Rad_score to comprehensively evaluate their prognostic performance. A final risk stratification, integrating left ventricular ejection fraction (LVEF), the extent of late gadolinium enhancement (LGE), and Rad_score, was established and compared with one based on LVEF alone.</p><p><strong>Statistical tests: </strong>The prognostic implications of the Rad_score were evaluated using univariable and multivariable Cox proportional hazards models. A P value <0.05 was considered significant.</p><p><strong>Results: </strong>During a median follow-up of 3.1 years, 139 patients (17%) in the training set and 30 patients (15%) in the testing set experienced MACE. Rad_score was identified as a significant risk factor for MACE, with a hazard ratio of 1.46 (1.38-1.55) (P < 0.01) in univariate Cox analysis. The risk stratification reclassified the risk for 33% of the study population in the training set and 34% in the testing set.</p><p><strong>Data conclusion: </strong>Myocardial cine radiomics are associated with MACE risk in STEMI patients and provide incremental improvement in risk stratification when combined with traditional parameters.</p><p><strong>Plain language summary: </strong>The development of radiomics has introduced new perspectives in both the diagnosis and prognosis of cardiovascular diseases. However, the incremental prognostic value of incorporating myocardial cine radiomics into predictive models for major adverse cardiovascular events (MACE) risk in patients with ST-elevation myocardial infarction (STEMI) remains unclear. This study integrates radiomics with traditional clinical parameters and cardiac magnetic resonance imaging (MRI) to evaluate its added value in assessing MACE risk in STEMI patients. The results demonstrate that radiomics is significantly associat","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}