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Unraveling the physiology of the autonomic nervous system: An unlikely collaboration between Arturo Rosenblueth and Walter Cannon. 揭开自律神经系统生理学的神秘面纱:阿图罗-罗森布卢埃斯和沃尔特-坎农之间不太可能的合作。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-02-01 Epub Date: 2024-03-22 DOI: 10.1177/09677720241237787
Luke A Schwerdtfeger

This article details the collaboration between Dr Walter B. Cannon (1871-1945) and Dr Arturo Rosenblueth (1900-1970) at the Department of Physiology at Harvard Medical School (HMS) in the 1930s-1940s. Cannon was a renowned physiologist whose Department of Physiology was home to scientists from around the globe. Rosenblueth joined the Department as a Research Fellow in 1930. Over the following 15 years, Rosenblueth and Cannon co-authored over 20 papers and one book. Rosenblueth ended his tenure at HMS as an assistant professor before returning to Mexico to head a newly created institute of physiology. This article draws from personal and professional correspondences between Cannon and Rosenblueth at HMS in the 1930s and early 40s. These letters, along with others from those at the Department of Physiology and the greater Harvard community paint a picture of the feeling towards Latin American scientists at that time. Finally, this brief survey illuminates some of the contributions of the many Latin American scholars who worked in the department during these years. The diverse backgrounds of these talented young scientists coupled with immense support from Cannon and Rosenblueth enabled remarkable discoveries and innovations in neurophysiology throughout the first half of the 20th century.

本文详细介绍了沃尔特-B-坎农博士(1871-1945 年)和阿图罗-罗森布卢埃斯博士(1900-1970 年)在 20 世纪 30 年代至 40 年代在哈佛大学医学院生理学系的合作。坎农是著名的生理学家,他所在的生理学系汇集了来自世界各地的科学家。罗森布鲁斯于 1930 年作为研究员加入该系。在随后的 15 年中,罗森布卢埃斯和坎农合作撰写了 20 多篇论文和一本著作。罗森布卢埃斯以助理教授的身份结束了他在 HMS 的任期,随后返回墨西哥领导一个新成立的生理学研究所。本文摘自 20 世纪 30 年代和 40 年代初坎农与罗森布卢埃斯在哈佛医学院的个人和专业通信。这些信件以及其他来自生理学系和哈佛大学社区的信件描绘了当时人们对拉美科学家的看法。最后,这份简短的调查报告揭示了这些年在生理学系工作的许多拉美学者的一些贡献。这些才华横溢的年轻科学家背景各异,再加上坎农和罗森布卢埃斯的大力支持,使他们在整个 20 世纪上半叶的神经生理学领域取得了卓越的发现和创新。
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引用次数: 0
A 'worthy disciple of Galen', 'ardent sportsman' and 'expert swordsman': Henry Kipping (1726-1785) apothecary and surgeon at Brighton, England. “盖伦值得尊敬的弟子”、“热心的运动员”和“剑术专家”:亨利·基平(1726-1785),英格兰布莱顿的药剂师和外科医生。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-02-01 Epub Date: 2023-07-27 DOI: 10.1177/09677720231190856
Maxwell J Cooper, Jason Heath

Henry Kipping (1726-1785) was an apothecary and surgeon in Brighton, England. Here we present a series of contemporary references to Kipping from newspaper, book, archive and web-based resources. Some relate to his medical practice (resuscitating a 'drowned' elderly physician and a fisherman, bleeding a member of parliament who had fallen from his horse and praising a nostrum for the 'gravel and stone'). Social references include a duel with an army officer whose sword Kipping confiscated. Kipping appears to have been popular, connected with members of Brighton's high society and passionate about traditional past times, e.g. swordsmanship, horse riding and hunting on the Sussex downs. Indeed, Kipping's horse ran in the earliest known horse race in Brighton (1770). He was consulted by notable local residents including the Thrale family of Brighton and Lady Wilhelmina Shelley (the latter evidenced by Kipping partaking in her funeral procession in 1772). Kipping lived and practised at 28 West street, a road most famous for its (now lost) George Inn where King Charles II stayed just prior to his escape to Normandy. Kipping comes across as a colourful and eccentric clinician.

亨利·基平(1726-1785)是英国布莱顿的一名药剂师和外科医生。在这里,我们从报纸、书籍、档案和网络资源中展示了一系列关于基平的当代参考文献。其中一些与他的医疗实践有关(救活了一位“溺水”的老年医生和一位渔夫,给一位从马上摔下来的国会议员放血,并称赞一种药方具有“砾石和石头”的功效)。社会参考包括与一名军官的决斗,他的剑被基平没收了。基平似乎一直很受欢迎,与布莱顿上流社会的成员有联系,对传统的过去充满热情,比如剑术、骑马和在苏塞克斯山间狩猎。事实上,基平的马参加了在布莱顿举行的已知最早的赛马比赛(1770年)。当地著名的居民,包括布莱顿的瑟莱家族和威廉敏娜·雪莱夫人(1772年基平参加了她的葬礼),都曾向他咨询过。基平在西街28号生活和工作,这条路最著名的是它的乔治旅馆(现在已经丢失了),国王查理二世在逃往诺曼底之前就住在那里。基平给人的印象是一个色彩缤纷、古怪的临床医生。
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引用次数: 0
Ben Weinstein, MD (1913-1974) and his enduring impact on the history of medicine experience in medical school.
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-01-24 DOI: 10.1177/09677720241305070
Michael C Trotter

The history of medicine as a component of the medical school curriculum has been a long-standing subject of debate and controversy. Ultimately, local factors may determine this experience and be aligned with or outside of the curriculum. The opportunity at Tulane University School of Medicine is long-standing and successful. It came to fruition through the efforts of Benjamin Bernard Weinstein, MD. A native New Orleanian, he received his undergraduate (1933) and medical (1937) degrees from Tulane as well as his training in obstetrics and gynaecology. He then joined the faculty and remained there until 1953 when he entered private practice with an interest in reproductive medicine. Weinstein was internationally known in the field, travelling the globe as a prominent educator and intersecting with world leaders. But his passion was the Tulane History of Medicine Society, founded by Weinstein in 1933 as a medical student. He became its guiding force and benefactor and built the foundation that remains highly relevant and successful 91 years later with a lengthy list of distinguished Weinstein Lecturers annually. Following his death in 1974, his family has continued to engage and support the Society. Weinstein's legacy of an enriched life through the study and knowledge of the history of medicine continues through the Society.

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引用次数: 0
Annie Dodge Wauneka: Legendary Mother of the Navajo people. 安妮·道奇·瓦内卡:传说中的纳瓦霍人的母亲。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-01-21 DOI: 10.1177/09677720241306384
Savannah Newell

Annie Dodge Wauneka was an activist and public servant whose decades long career focused extensively on improving the welfare of the Navajo Community. She campaigned to increase education among those living on the Navajo Reservation through working on the Tribal Council, completing personal visits, and producing educational material to improve hygiene. Annie's biggest fight was against tuberculosis. By bridging old traditions with new medicine, Annie encouraged people to seek treatment from hospitals and remain there throughout treatment. This reduced mortality significantly while closing the health disparity that existed between Native populations and the United States collectively.

安妮·道奇·瓦内卡是一位活动家和公务员,她数十年的职业生涯广泛致力于改善纳瓦霍社区的福利。她通过在部落委员会工作、完成个人访问和制作改善卫生的教育材料,开展了在纳瓦霍保留地居民中提高教育水平的活动。安妮最大的斗争是与肺结核作斗争。通过将旧传统与新医学结合起来,安妮鼓励人们去医院寻求治疗,并在整个治疗过程中留在那里。这大大降低了死亡率,同时缩小了土著居民和美国人之间存在的健康差距。
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引用次数: 0
Marcello Malpighi's failing health, death, and the remarkable story of his mortal remains. 马塞洛·马尔皮吉每况愈下的健康状况、死亡,以及他遗体的非凡故事。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-01-09 DOI: 10.1177/09677720241307612
Roberto F Nicosia

Marcello Malpighi, renowned as the founder of microscopic anatomy, faced many challenges throughout his life. Among these was his frail health, which deteriorated in his early 40s when he developed kidney stones. He struggled with arthritic pain and heart palpitations, which, along with his renal condition, gradually became worse as he got older. His clinical history and autopsy findings also suggest he may have suffered from hypertension, a disease unknown in the seventeenth century. Toward the end, his declining health was complicated by cardiovascular failure. After he died from a stroke, his mortal remains lay unburied for months due to a dispute over the ownership of the burial place. They were finally entombed but relocated multiple times over the next three centuries. An examination of the bones currently housed in his memorial, conducted on the tercentenary of his birth and critically revisited years later, raised doubts about their authenticity. In this paper, I review the causes of Malpighi's poor health and death and delve into the intriguing story of his mortal remains.

Marcello Malpighi是著名的显微解剖学的创始人,他一生都面临着许多挑战。其中之一就是他虚弱的身体,在40岁出头时,他患上了肾结石,身体状况恶化。他与关节炎疼痛和心悸作斗争,随着年龄的增长,他的肾脏状况逐渐恶化。他的临床病史和尸检结果也表明,他可能患有高血压,这种疾病在17世纪还不为人知。临终前,他每况愈下的健康状况因心血管衰竭而变得更加复杂。他因中风去世后,由于对墓地所有权的争议,他的遗体几个月没有被埋葬。他们最终被埋葬,但在接下来的三个世纪里多次搬迁。在他诞辰300周年之际,人们对他纪念馆里的遗骨进行了检查,并在几年后对其真实性进行了批判性的重新审视。在本文中,我回顾了马尔皮吉的健康状况不佳和死亡的原因,并深入研究了他的遗体的有趣的故事。
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引用次数: 0
Marcello Malpighi (1628-1694): His life, discoveries and struggles with the detractors of microscopic anatomy. 马尔切洛·马尔皮吉(1628-1694):他的一生、发现以及与诋毁显微解剖学的人的斗争。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-01-08 DOI: 10.1177/09677720241307620
Roberto F Nicosia

Marcello Malpighi is widely recognized as the founder of microscopic anatomy. His seminal discoveries of the pulmonary alveoli, blood capillaries, and renal glomeruli revolutionized existing medical knowledge, earning him fame and international recognition. He discovered the respiratory system of insects and described, for the first time, their excretory apparatus. He laid the foundations of modern embryology by characterizing the early stages of organ development in the chick embryo and was among the first to study the anatomy and biology of plants. Malpighi also faced family challenges, including his younger brother's involvement in a homicide, and relentless attacks by followers of traditional medicine. The purpose of this paper is to revisit Malpighi's extraordinary life and works, focusing on his struggles with detractors, who questioned the usefulness of his microscopic observations and resisted the new ideas of modern medicine.

Marcello Malpighi被广泛认为是显微解剖学的创始人。他对肺泡、毛细血管和肾小球的开创性发现彻底改变了现有的医学知识,为他赢得了声誉和国际认可。他发现了昆虫的呼吸系统,并首次描述了它们的排泄器官。他通过描述小鸡胚胎器官发育的早期阶段,奠定了现代胚胎学的基础,并且是最早研究植物解剖学和生物学的人之一。马尔皮吉还面临着家庭挑战,包括他的弟弟卷入了一起凶杀案,以及传统医学追随者的无情攻击。本文的目的是重温马尔皮吉非凡的生活和作品,重点关注他与批评者的斗争,这些批评者质疑他的微观观察的有效性,并抵制现代医学的新思想。
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引用次数: 0
Dr Pranjivandas Manekchand Mehta MD, MS, FCPS 1889-1981 and Caraka Samhita (1949). Pranjivandas Manekchand Mehta MD, MS, FCPS 1889-1981和Caraka Samhita(1949)。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2024-12-26 DOI: 10.1177/09677720241304740
Sunil K Pandya

Pranjivandas Manekchand Mehta (1889-1981), MD, MS, FCPS, also known as Dr P M Mehta, was an Indian physician and surgeon in Bombay, who then became the personal physician of the Maharajah Jamsaheb of the former Princely State of Nawanagar, Gujarat, British India. The Jamsaheb appointed Mehta as the Chief Medical Officer of Nawanagar, and with the guidance of the French radiologist, Jean Saidman, oversaw the construction of the first solarium in India. Mehta persuaded the Jamsaheb to fund an institution dedicated to Ayurvedic studies, named the Shri Gulabkunverba Ayurvedic Society, the precursor to the first Ayurveda college in India, and he became the Director of the Central Institute of Research on Indigenous Systems, which later came under the umbrella of the Institute of Teaching and Research in Ayurveda, Jamnagar. P M Mehta was instrumental in establishing a medical college in Nawanagar's capital, now known as the M. P. Shah Medical College, Jamnagar. His work in Ayurvedic medicine and assembling a group of Sanskrit scholars led to a detailed translation of the ancient Sanskrit medical text Çaraka Samhita, also spelt Charaka Samhita, into English, Hindi and Gujarati, published in six volumes in 1949. In 2022, the World Health Organization and the Indian Government established the Global Centre for Traditional Medicine in India, and chose Jamnagar as its location, noting that that was where graduate-level Ayurvedic studies began. Mehta's efforts in Ayurvedic education and the Çaraka Samhita translations have largely been forgotten over several decades, and a recently issued reprint omits the mention of his name. The aim of this paper is to give some glimpses into Mehta's life and his role in the revival of Ayurveda in India, during the lead-up to and during the early years of independent India.

Pranjivandas Manekchand Mehta (1889-1981), MD, MS, FCPS,也被称为P M Mehta医生,是孟买的一名印度内科医生和外科医生,后来成为英属印度古吉拉特邦前纳瓦纳加尔王侯邦的Jamsaheb的私人医生。Jamsaheb任命Mehta为纳瓦纳加尔的首席医疗官,并在法国放射科医生Jean Saidman的指导下,监督了印度第一个日光浴室的建设。Mehta说服Jamsaheb资助了一个专门研究阿育吠陀的机构,命名为Shri Gulabkunverba阿育吠陀学会,这是印度第一所阿育吠陀学院的前身,他成为了土著系统中央研究所的主任,该研究所后来隶属于Jamnagar阿育吠陀教学与研究研究所。P·M·梅塔在纳瓦讷格尔首府建立了一所医学院,现在被称为贾姆纳格尔的M·P·沙阿医学院。他在阿育吠陀医学方面的工作,以及召集一群梵语学者,将古梵语医学文献Çaraka Samhita(也拼写为Charaka Samhita)详细翻译成英语、印地语和古吉拉特语,并于1949年出版了六卷。2022年,世界卫生组织和印度政府在印度建立了全球传统医学中心,并选择贾姆纳格尔作为中心所在地,指出那里是阿育吠陀医学研究生研究的起点。几十年来,梅塔在阿育吠陀教育和Çaraka Samhita翻译方面的努力在很大程度上被遗忘了,最近发行的重印版没有提到他的名字。本文的目的是给一些瞥见梅塔的生活和他在印度阿育吠陀的复兴中所扮演的角色,在印度独立之前和早期。
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引用次数: 0
Story of a Levantine family in late Ottoman Constantinople: Dr Julius van Millingen and Dr Edwin van Millingen. 奥斯曼帝国晚期君士坦丁堡一个黎凡特家庭的故事:朱利叶斯·范·米林根博士和埃德温·范·米林根博士。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2024-12-23 DOI: 10.1177/09677720241304743
Yesim Isil Ulman, Ceren Gülser İlikan Rasimoğlu

This paper examines Drs Julius and Edwin van Millingen, father and son physicians from a Constantinople-based Levantine family. They thrived in late 19th-century Ottoman Constantinople, a period of modernization aimed at survival amid decline. The profiles of Millingen family members set an exemplary case of the Levantine families who preferred to settle and pursue their careers in the Ottoman capital, particularly for generations in the Pera (Beyoglu) bourgeoisie, associated with the prominent industrial and literate centers in Europe. Dr Julius Michael van Millingen (1800-1878) was physician and companion to Lord Byron (1788-1824), and served as the private physician of the Sultan Abdulmecid (1839-1861), and the Queen Mother, Bezm-i Alem Valide Sultan (1807-1853) at the Imperial Ottoman Palace. He published considerable writings on balneology, then. His son, Dr Edwin van Millingen (1850-1900), an Istanbul-born ophthalmologist, worked at top hospitals, taught at the Imperial School of Medicine, and collaborated with the Société Impériale de Médecine. He reported on common ophthalmological diseases, with detailed statistics and meticulously organized tabular data. The multicultural lives of this Levantine family offer a unique glimpse into 19th-century Turkish medical history, reflecting close ties with Western medical centers.

本文考察了来自君士坦丁堡黎凡特家庭的医生朱利叶斯和埃德温·范·米林根父子。他们兴盛于19世纪晚期的奥斯曼君士坦丁堡,这是一个旨在在衰落中生存的现代化时期。米林根家族成员的身世为那些更愿意在奥斯曼帝国首都定居和追求事业的黎凡特家庭树立了一个典范,特别是佩拉(Beyoglu)资产阶级的几代人,他们与欧洲著名的工业和文化中心有关。朱利叶斯·迈克尔·范·米林根医生(1800-1878)是拜伦勋爵(1788-1824)的医生和伴侣,也是奥斯曼帝国皇宫的苏丹阿卜杜勒-麦吉德(1839-1861)和太后贝兹姆-伊·阿莱姆·瓦利德·苏丹(1807-1853)的私人医生。于是,他发表了大量关于细菌学的著作。他的儿子埃德温·范·米林根医生(1850-1900)是一名伊斯坦布尔出生的眼科医生,曾在顶级医院工作,在帝国医学院任教,并与社会医学会合作。他对常见的眼科疾病进行了报道,并进行了详细的统计和精心组织的表格数据。这个黎凡特家庭的多元文化生活为19世纪土耳其医学史提供了独特的一瞥,反映了与西方医疗中心的密切联系。
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引用次数: 0
Vavro Šrobár: Slovak politician and publicist as a medical doctor involved (also) in the history of medicine. Vavro Šrobár:斯洛伐克政治家和公关人员,也是参与医学史的医生。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2024-12-18 DOI: 10.1177/09677720241307622
Matej Gogola

Vavro Šrobár was a prominent political figure in East-Central Europe. He played a pivotal role in the establishment and development of the First Czechoslovak Republic, which emerged following the dissolution of the Austro-Hungarian Empire. He was the first Minister to exercise full administrative authority in overseeing the Provisional Government of Slovakia, and throughout his career, including until the end of his life, he held several significant political positions, such as Minister of Public Health and Physical Education, Minister of Unification, Minister of Education and National Enlightenment, and Minister of Finance. Among his numerous contributions, Šrobár was unquestionably one of the key figures behind the founding of the University in Bratislava. His name subsequently became closely associated with the first decades of the Bratislava Faculty of Medicine at Comenius University, founded in 1919. In the field of medicine, he is regarded as one of the founding figures of social medicine in Slovakia. This article will primarily examine Šrobár's medical accomplishments within the context of healthcare in present-day Slovakia during the first quarter of the 20th century and his work at the Faculty of Medicine in Bratislava. Additionally, we will explore the connection between his person and the early history of medicine in Slovakia.

瓦夫罗Šrobár是东中欧著名的政治人物。他在奥匈帝国解体后出现的第一捷克斯洛伐克共和国的建立和发展中发挥了关键作用。他是第一个在监督斯洛伐克临时政府方面行使充分行政权力的部长,在他的整个职业生涯中,包括直到他生命的尽头,他担任过几个重要的政治职务,如公共卫生和体育部长、统一部长、教育和民族启蒙部长以及财政部长。在他的众多贡献中,Šrobár无疑是布拉迪斯拉发大学成立背后的关键人物之一。他的名字后来与1919年成立的夸美纽斯大学布拉迪斯拉发医学院的头几十年紧密联系在一起。在医学领域,他被视为斯洛伐克社会医学的奠基人之一。本文将主要研究Šrobár的医疗成就在医疗保健的背景下,在今天的斯洛伐克在20世纪的第一季度和他在布拉迪斯拉发医学院的工作。此外,我们将探讨他本人与斯洛伐克早期医学史之间的联系。
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引用次数: 0
Sir Nicholas Gilbourne's (magical) cross-over trial of 1631. 尼古拉斯·吉尔伯恩爵士1631年的(魔法)交叉审判。
IF 0.3 4区 哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2024-12-15 DOI: 10.1177/09677720241304738
Max Cooper, Sarah Cooper

We describe a basic 'cross-over' trial undertaken by Sir Nicholas Gilbourne of Kent, England, in or before 1631. This was used to test the effectiveness of 'weapon salve', an ointment claimed to cure 'sympathetically' (i.e. remotely) by application to the weapon that inflicted an injury. Gilbourne reports very basic outcomes but these represent key stages of a modern cross-over trial: no treatment, treatment, no treatment, treatment. We discuss the value of such historical vignettes - even a magical one - for medical students in two respects: understanding research methodology and learning about consultation strategies. Gilbourne's conclusion is clearly fanciful but the basic principles behind his experiment are sound. Historical examples like this can inspire medical students to think critically about research methods and treatment strategies.

我们描述了英国肯特郡的尼古拉斯-吉尔本爵士(Sir Nicholas Gilbourne)在 1631 年或之前进行的一项基本 "交叉 "试验。该试验用于测试 "武器药膏 "的疗效,这种药膏声称可以通过涂抹在造成伤害的武器上进行 "交感"(即远程)治疗。吉尔本报告了非常基本的结果,但这些结果代表了现代交叉试验的关键阶段:不治疗、治疗、不治疗、治疗。我们从两个方面讨论了这种历史小故事(即使是神奇的故事)对医学生的价值:了解研究方法和学习咨询策略。吉尔本的结论显然是虚构的,但他实验背后的基本原理是正确的。这样的历史案例可以启发医学生对研究方法和治疗策略进行批判性思考。
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引用次数: 0
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Journal of Medical Biography
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