Journal of Medical Biography最新文献

Alexander Blackrie (bap. 1702, d. 1772) was a Scottish Surgeon-Apothecary who attended Aberdeen's grammar school and Marischal College. He served as surgeon-general in India and practised at Bromley, Kent, England. In later life, he suffered from the 'gravel and stone' i.e., urological stones. This triggered an enquiry into the lucrative medication of Dr Chittick of Bath. Blackrie deduced it to be nothing more than soap-lye (Sodium hydroxide) and went on to formulate his own version ('Blackrie's lixivium'). Blackrie undertook comparative experiments on the efficacy of these two products at dissolving equally-sized fragments of the same urinary stone. In 1763, he published his proposal to compare the two products in patients. This called for: selection of patients 'afflicted in the same degree', randomisation by 'dividing them equally by lot', the 'experiment' to be 'repeated' and the number of participations to be 'large'. Although never implemented, Blackrie's proposal is an early model of a randomised controlled trial and may be the first description of a non-inferiority trial. His use of the term 'decisive' experiment and reference to James Jurin FRS may offer a link with Hauksbee the Younger's 1743 proposed 'experimentum crucis'. Blackrie's contribution to the development of fair comparisons of treatments deserves greater recognition.

In the early eighteenth century, Dominique Parennin, a French Jesuit missionary in China, wrote at the behest of the Emperor Kangxi a manuscript in the Manchu language which combined some of the theories of traditional Chinese medicine with Western medical concepts. One of the surviving manuscripts of this "Manchu Anatomy," sent by Parennin to the French Royal Academy of Sciences in 1723, is now kept in the Muséum d'Histoire Naturelle in Paris. This work, "Ge ti ciowan lu bithe," has recently been translated into modern Mongolian, affording an opportunity to research Parennin, his life and work, and the significance of the "Manchu Anatomy."

Judson Chesterman (1903-1987) was a surgeon working in Sheffield, United Kingdom in the mid-20th century. Born in Bath, Somerset, he attended Bristol Medical School before completing junior doctor positions around England. He developed his skills in thoracic surgery during a Fellowship with Evarts Graham (1883-1957) at Barnes Hospital, St Louis, Missouri and by the mid-1950s was also performing a large number of closed cardiac procedures. In 1955, he performed the first mitral valve replacement in the world, using a prosthesis of his own design, but the patient only survived for around 18 hours. Recognising the limitations of off-pump surgery, he visited the University of Minneapolis before building his own bypass machine and used it in two patients, the first in February 1957, one of the earliest outside the United States of America to do so. In retirement he established an osteoarchaeology laboratory and made additional contributions to that field.

Vera Mikhailovna Danchakova (1877-1950), also written in English as Danchakoff and in German as Dantschakoff, was the first woman to graduate with a PhD in Russia. She was a person of many interests and a strong passion for teaching and social justice that may have interfered with her pioneering stem cell research and cell biology, which was far ahead of its time. Danchakova significantly contributed to the unitarian theory of haematopoiesis along with its founder Alexander A. Maximow. She studied the origin of blood cells, the differentiation of tissues and organs in the process of embryonic development of animals, the formation of germ cells and the effect of hormones on the development of organisms. She discovered the role of stem cells in the laying of new tissues, the proof of the extragonadal origin of primary germ cells in birds and the development of methods for transplanting tissues into live embryos. She has been named 'the mother of stem cells' for her investigations of progenitors of cells.

Professionalism and medical ethics, while similar, are often viewed in different contexts. An historical and social science analysis reveals that professionalism is a complex skill that can be developed over time. The key components of professionalism, as defined by the American Physical Therapy Association, include accountability, altruism, compassion, excellence, integrity, professional duty, and social responsibility. Throughout history, physicians have been concerned with medical ethics and professionalism. In the Golden Age of Islam, principles such as excellence, honour, integrity, accountability, and duty were important in shaping the professional behavior of physicians. Adab al-Tabib, an ancient work, by Ishāq bin Ali al-Ruhawi focuses on ethical guidelines and teachings related to medical ethics in the Islamic civilization. Many of the ethical issues in this book are of foremost importance as components of professionalism. However while the examples of medical ethics guidelines that pre-existed Adab al-Tabib such as the Hippocratic Oath, are not mentioned. As one of the first statutes of medical ethics in Islamic civilization, Ruhawi is a model for many doctors in the Golden Age of Islam, and over the years his principles have greatly influenced the professional view of physicians.

Danish polymath Niels Stensen journeyed to the Dutch Republic (1660) to further his medical studies. While staying with Blasius in Amsterdam, he made an important discovery in the anatomy of the parotid duct: the ductus Stenonianus. Blasius later took credit, leading to a dispute won by Stensen. Realising he could learn little in Amsterdam, Stensen moved to Leiden University (July 1660). Here, he studied under renowned professors Sylvius and van Horne and became friends with talented fellow students Swammerdam, Ruysch, and de Graaf, who significantly contributed to anatomy and reproductive medicine. Stensen discovered various anatomical and physiological aspects, leading to his doctorate from Leiden. Here, he met Spinoza and maintained correspondence with him. Stensen left Leiden (1664), spending time in Paris, and moved to Florence (1666), joining the Accademia del Cimento. His interests expanded from anatomy to geology; he converted to Catholicism (1667), was ordained as a priest (1675) and became bishop. His ecclesiastical duties took him to Germany, where he lived a life of asceticism, dying in 1686. His remains were moved to Florence and buried in the Basilica of San Lorenzo. Stensen's journey reflects a commitment to knowledge and spirituality, making him a figure of intellectual and religious significance.

Albert Sharman was a Glasgow-born and based gynaecologist who pioneered research into infertility and the diagnosis of pregnancy using new techniques of investigation and treatment, many of his own design. His Fertility Clinic, opened in 1931, was the first in Britain, and became a model for those that followed. Working at Glasgow's Royal Samaritan Hospital for Women, he published widely in the medical press, especially the British Medical Journal and the Lancet, and he authored and co-edited several books, some aimed at a medical audience while others sought to explain complex issues surrounding puberty, fertility and the menopause to the general public.

Andrew Duncan Senior and John Roberton were medical figures who wrote about Medical Police, the forerunner of Public Health, at the turn of the 18th century in Edinburgh. Duncan was an establishment figure, already a Professor at Edinburgh University Medical School when he began a series of lectures on the legal context of medicine, the first of its kind in the UK. Roberton was a less conventional person whose medical qualifications were dubious but who wrote a textbook on Medial Police, the first in the English language. Both were influenced by the German Johann Frank, but developed very different models of Medical Police. Duncan's form depended on education and reflected social attitudes in post-enlightenment Scotland while Roberton was a committed miasmatist and championed an interventional, sanitarian approach. This approach was imaginative, employing an army of medical officers to enforce the policy funded by extra taxes, but this proved too interventional for 19th century Scotland, Roberton left Edinburgh and went to London and never again published on the topic of Medical Police or lectured on the topic. By contrast, Duncan's influence continued through the Chair of Medical Police and Medical Jurisprudence at the University of Edinburgh that he initiated and championed.

In 1836, an article was published in which the terms Rindensubstanz (cortical substance) and Marksubstanz (medullary substance) were introduced for the first time with reference to the adrenal glands. The author was indicated as 'Dr Nagel', without any further specification. Modern scientific literature often identifies the author's name as 'N. Nagel', without citing any primary source. Here, Nagel is positively identified as Moritz Nagel (1808-1871), a student of the German physiologist and anatomist Johannes Peter Müller (1801-1858), who graduated in Medicine at the University of Berlin in 1834. The 1836 article represented the German version of Nagel's Latin dissertation. Nagel later left Müller to devote himself to obstetrics and gynaecology. Although current literature attributes to Nagel the merit for introducing the terms 'cortical' and 'medullary', based on the testimony of Nagel himself and that of Jakob Henle (1809-1885), I conclude that Nagel described and illustrated results previously anticipated by Müller in 1832. Yet, considering that Nagel's description was the first in print, that he published following his own work carried out under Müller's supervision and apparently with Müller's blessing, I believe it is fair to conclude that the credit for the discovery should be justifiably attributed jointly to Müller and Nagel.