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Analysis of the Temperature Elevation of the Dual-Wavelength Diode Laser and the Er, Cr: YSGG Laser in Oral Soft Tissue Incisions 双波长二极管激光与Er, Cr: YSGG激光在口腔软组织切口中的温升分析
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-09-25 DOI: 10.34172/jlms.2023.37
Alaa Jamal Al-Ani, Ammar Saleh Al-Alawi, Hanan Jafer Taher
Introduction: Lasers are one of the most advantageous tools that have been used in a variety of medical fields. Soft tissue management is an important part of oral and maxillofacial surgery. There are different surgical procedures for management; one of them is laser surgery. The purpose of this study was to compare the dual-wavelength diode laser and the Er, Cr: YSGG laser to choose the most effective laser for a soft tissue incision in oral and maxillofacial surgery regarding temperature elevation. Methods: A dual-wavelength diode laser (810 and 980 nm) with 1.5 W and 2.5 W power outputs and an Er, Cr: YSGG (2780 nm) with 2.5 W and 3.5 W power outputs were used to make 50 incisions in six freshly dissected sheep tongues. The temperature means were measured at initial, maximum temperatures, as well as the temperature rise (difference between initial and maximum), and all were compared between the groups of soft tissue. Results: The lowest mean temperature rise was observed with a 2.5 W Er, Cr: YSGG laser, and the highest mean temperature rise was observed with a 2.5 W diode laser, and all samples from the two lasers showed a statistically significant difference (P<0.05) in the temperature rise except the 1.5 W diode, which is higher but not statistically significantly different from the 3.5 W Er, Cr: YSGG laser (P=0.100). Conclusion: The power output of 2.5 W of an Er, Cr: YSGG laser produced low levels of temperature rise compared to a diode laser and produced surgical incisions with a lower probability of heat damage to surrounding tissues.
激光是最有利的工具之一,已被用于各种医疗领域。软组织处理是口腔颌面外科的重要组成部分。有不同的外科治疗方法;其中之一就是激光手术。本研究的目的是比较双波长二极管激光和Er, Cr: YSGG激光,以选择最有效的激光用于口腔颌面外科软组织切口的温度升高。方法:采用功率分别为1.5 W和2.5 W的双波长二极管激光器(810和980 nm)和功率分别为2.5 W和3.5 W的Er, Cr: YSGG激光器(2780 nm)在6只新鲜解剖的羊舌上切开50个切口。测量初始温度、最高温度、温升(初始与最高温度之差)的温度均值,并比较各组软组织间的温度均值。结果:2.5 W Er, Cr: YSGG激光器的平均温升最低,2.5 W二极管激光器的平均温升最高,除1.5 W二极管激光器的温升高于3.5 W Er, Cr: YSGG激光器外,两种激光器样品的温升差异均有统计学意义(P= 0.05),但差异无统计学意义(P=0.100)。结论:与二极管激光器相比,功率为2.5 W的Er, Cr: YSGG激光器产生的温升水平较低,手术切口对周围组织的热损伤概率较低。
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引用次数: 0
Therapeutic Effects of Low-Level Laser on Male Infertility: A Systematic Review 低水平激光治疗男性不育症的疗效综述
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-09-25 DOI: 10.34172/jlms.2023.36
Amirreza Eghbaldoost, Seyed Pooria Salehi Mashhadsari, Erfan Ghadirzadeh, Alireza Ghoreifi, Farzad Allameh
Introduction: The objective of this study was to assess the effectiveness and safety of photobiomodulation (PBM) in the treatment of male infertility. Methods: We searched Google Scholar, PubMed, and the reference sections of relevant papers published from January 1, 2000 to September 23, 2022. We retrieved all publications related to the impact of PBM on male infertility. After reviewing the titles, abstracts, and full texts, we included fifteen papers in the research. The studies involved 477 semen samples (in vitro studies) and 70 male participants (randomized clinical trials). Results: All 14 in vitro studies that evaluated effectiveness reported that PBM was successful in increasing the proportion of progressive sperms in semen samples. Various methods were used to evaluate the safety. One study with a sample size of 58 concluded that PBM was not a safe treatment, whereas the other ten studies confirmed its safety. Only one clinical trial evaluated the effect of laser acupuncture on male infertility and found improvements in sperm progressive motility without any serious adverse effects. Conclusion: All 15 studies evaluating effectiveness reported that the low-level laser was effective for increasing the proportion of progressive sperm in semen samples and that it was safe to use. However, due to the heterogeneity of population characteristics, source characteristics, duration of exposure, sample size, and instruments for measuring safety and efficacy, we cannot conclude that the positive results obtained from the reviewed studies are solely attributable to the low-level laser on the sperm samples.
前言:本研究的目的是评估光生物调节(PBM)治疗男性不育症的有效性和安全性。方法:检索2000年1月1日至2022年9月23日发表的相关论文的Google Scholar、PubMed和参考文献部分。我们检索了所有与PBM对男性不育影响相关的出版物。在审阅了题目、摘要和全文后,我们纳入了15篇论文。这些研究涉及477份精液样本(体外研究)和70名男性参与者(随机临床试验)。结果:所有14项评估有效性的体外研究报告称,PBM成功地增加了精液样本中进展精子的比例。采用多种方法评价其安全性。一项有58个样本量的研究得出结论,PBM不是一种安全的治疗方法,而其他10项研究证实了它的安全性。只有一项临床试验评估了激光针灸对男性不育症的影响,发现精子进行性运动的改善没有任何严重的不良反应。结论:所有15项评估有效性的研究都报告了低水平激光对增加精液样本中进展性精子的比例是有效的,并且是安全的。然而,由于人群特征、源特征、暴露时间、样本量以及测量安全性和有效性的仪器的异质性,我们不能得出结论,从所审查的研究中获得的阳性结果完全归因于低水平激光对精子样本的影响。
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引用次数: 0
Effect of the 1064 nm Nd: YAG Laser on the MICs of Antifungals Used in Clinical Practice for the Treatment of Fungal Nail Infections 1064 nm Nd: YAG激光对临床治疗真菌指甲感染抗真菌药物mic的影响
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-09-24 DOI: 10.34172/jlms.2023.35
Taraneh Razavyoon, Seyed Jamal Hashemi, Parvin Mansouri, Roshanak Daie Ghazvini, Sadegh Khodavaisy, Heydar Bakhshi, Saham Ansari, Zahra Rafat, Nahid Nikkhah, Bahram Mohajer, Shayesteh Razavyoon, Davoud Roostaei
Introduction: The fungal nail infection (onychomycosis) involves 18%-40% of all nail disorders, which, although not fatal, can cause mechanical, aesthetic, occupational, and economic problems. Drug treatments due to prolonged treatment periods, drug interactions, adverse effects, and slow progression may associate with numerous negative outcomes. This study aimed to evaluate the long-pulsed 1064-nm Nd: YAG laser effect on fungal colonies and subsequently possible change in the minimum inhibitory concentrations (MICs) of common antifungals compared with the same non-lasered colonies as a novel way to investigate laser and antifungal interaction. Methods: Sixty onychomycosis samples consisting of saprophyte (n=20), dermatophyte (n=20), and yeast (n=20) duplicate colonies were isolated. A series was treated by a long-pulsed 1064-nm Nd: YAG laser. Afterward, the MIC (CLSI-M38-A2 and CLSI-M27-A3) of two series against common antifungals were compared. Results: After 1064-nm Nd: YAG laser irradiation in all 20 tested saprophytes, the MICs of terbinafine (P value<0.035) were changed, and in all 20 tested dermatophytes, the MICs of voriconazole (P value<0.021) were changed. Also, in all 20 tested yeasts, the MICs of caspofungin (P value<0.037) were changed. Moreover, in saprophytes, dermatophytes, and yeasts, significant changes in the MICs of itraconazole (P value<0.032), terbinafine (P value<0.025), and caspofungin (P value<0.037) were detected. Our result showed the GM MICs of the 1064-nm Nd: YAG laser in all saprophyte, dermatophyte, and yeast groups were lower than in the control group. Conclusion: The present study indicated that the long-pulsed 1064-nm Nd: YAG laser significantly changes the MICs of antifungals in onychomycosis clinical samples.
指甲真菌感染(甲真菌病)占所有指甲疾病的18%-40%,虽然不是致命的,但可以引起机械、美学、职业和经济问题。药物治疗由于治疗时间延长、药物相互作用、不良反应和缓慢的进展可能与许多负面结果相关。本研究旨在评估长脉冲1064 nm Nd: YAG激光对真菌菌落的影响,以及与相同的非激光菌落相比,常见抗真菌药物的最低抑制浓度(mic)可能发生的变化,作为研究激光与抗真菌相互作用的新方法。方法:对60份甲真菌标本进行分离,其中包括腐生菌(n=20)、皮肤菌(n=20)和酵母菌(n=20)重复菌落。采用长脉冲1064 nm Nd: YAG激光处理。然后比较两个系列对常见抗真菌药物的MIC (CLSI-M38-A2和CLSI-M27-A3)。结果:1064 nm Nd: YAG激光照射20种腐生植物后,特比萘芬的mic均发生变化(P值为0.035),伏立康唑的mic均发生变化(P值为0.021)。此外,在所有20个被试酵母中,caspofungin的mic (P值<0.037)都发生了变化。此外,在腐生植物、皮肤植物和酵母中,检测到伊曲康唑(P值<0.032)、特比萘芬(P值<0.025)和卡泊芬素(P值<0.037)的mic有显著变化。结果表明,1064 nm Nd: YAG激光在腐生植物、皮肤植物和酵母菌组的转基因mic均低于对照组。结论:长脉冲1064 nm Nd: YAG激光可显著改变甲癣临床样品中抗真菌药物的mic。
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引用次数: 0
Evaluation of the Effects of Photodynamic Therapy With Methylene Blue on Different Candida Species In Vitro 亚甲基蓝光动力疗法对不同假丝酵母菌体外治疗效果的评价
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-09-18 DOI: 10.34172/jlms.2023.34
Faezeh Khozeimeh, Atefeh Tavangar, Mehdi Razaghi Abyaneh, Milad Amini, Marzieh Ghayour
Introduction: Oral candidiasis is the most prevalent opportunistic infection of the oral cavity. The most common cause of this infection is Candida albicans. Considering the side effects of conventional antifungal therapies, this study aimed to evaluate the efficacy of photodynamic therapy with new methylene blue (a photosensitizer) in inhibiting the growth of C. albicans, C. tropicalis, C. glabrata, and C. krusei in vitro. Methods: In this experimental study, 200 samples of standard suspension (0.5 McFarland) were prepared from C. albicans, C. tropicalis, C. glabrata, and C. krusei (50 samples from each species). The samples of each species were divided into five groups (n=10), including photodynamic therapy with a photosensitizer, with or without laser irradiation, nystatin treatment, laser therapy, and control. Next, cultivation of samples was performed on Sabouraud dextrose agar, and the colony-forming units were determined after 24 hours of incubation at 37 °C. Data were analyzed in SPSS version 22 by means of the Kruskal-Wallis test (P<0.05). Results: The most sensitive and resistant species to nystatin therapy were C. glabrata and C. krusei, respectively. On the other hand, C. krusei was the most sensitive species to photodynamic therapy, and C. glabrata was the most resistant type to this treatment. The highest therapeutic effectiveness was attributed to nystatin therapy, although photodynamic therapy was also effective. Laser therapy was recognized as the least effective method. Conclusion: Photodynamic therapy with new methylene blue, as a suitable adjunct therapy, can be effective in the management of candidiasis. It may also be a potential novel treatment for immunocompromised patients with oral candidiasis.
口腔念珠菌病是口腔最常见的机会性感染。这种感染最常见的原因是白色念珠菌。考虑到常规抗真菌疗法的副作用,本研究旨在评估新型亚甲基蓝(光敏剂)光动力疗法在体外抑制白色念珠菌、热带念珠菌、光斑念珠菌和克鲁塞念珠菌生长的效果。方法:以白色念珠菌、热带念珠菌、光斑念珠菌和克鲁塞念珠菌各50份,制备标准悬浮液200份(0.5 McFarland)。每个物种的标本分为5组(n=10),包括光敏剂光动力治疗组、激光照射组、制霉菌素治疗组、激光治疗组和对照组。接下来,在Sabouraud葡萄糖琼脂上进行样品培养,37℃孵育24小时后测定菌落形成单位。数据在SPSS version 22中进行分析,采用Kruskal-Wallis检验(P<0.05)。结果:对制霉菌素治疗最敏感和最耐药的菌种分别为光秃秃夜蛾和克氏夜蛾。另一方面,对光动力处理最敏感的品种是克鲁西,对光动力处理最抗性的品种是光动力处理。最高的治疗效果归因于制霉菌素治疗,尽管光动力治疗也有效。激光治疗被认为是最不有效的方法。结论:新亚甲蓝光动力疗法是治疗念珠菌病的一种合适的辅助疗法。它也可能是一种潜在的治疗口腔念珠菌病免疫功能低下患者的新方法。
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引用次数: 0
Effect of Photodynamic Therapy on the Pushout Bond Strength of Resin-Based and Calcium Silicate-Based Endodontic Sealers 光动力疗法对树脂基和硅酸钙基根管密封剂推出结合强度的影响
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-09-10 DOI: 10.34172/jlms.2023.33
Saeede Zadsirjan, Mohammad Asnaashari, Atoosa Yazdani, Soolmaz Heidari, Tina Estarami
Introduction: This study aimed to assess the effect of photodynamic therapy (PDT) on the pushout bond strength (PBS) of resin-based and calcium silicate-based endodontic sealers. Methods: Forty single-canal teeth were assigned to four groups. After root canal preparation by the crown-down technique and smear layer removal, groups 1 and 2 served as the control group, and groups 3 and 4 underwent PDT by using a low-level diode laser as the light source and methylene blue as the photosensitizer (MB). The root canals in groups 1 and 3 were filled with AH26 sealer while the root canals in groups 2 and 4 were filled with Endoseal TCS. The samples were sectioned at 4, 8, and 12 mm from the apex tip (1mm thick slices). The PBS test was performed, and the mode of failure was determined in the coronal, middle, and apical thirds. The data were analyzed by the Kruskal-Wallis, Friedman, and Dunn tests. Results: No significant difference was noted in the PBS of resin-based and calcium silicate-based sealers in the apical, middle, or coronal thirds in the application of PDT (P>0.05). The PBS of AH26 was significantly higher than that of Endoseal TCS (P<0.05). Cohesive failure was the dominant mode of failure in the AH26 groups, while mixed failure was the dominant failure mode in the Endoseal TCS groups. Conclusion: PDT had no significant effect on the PBS of resin-based and calcium silicate-based sealers.
简介:本研究旨在评估光动力疗法(PDT)对树脂基和硅酸钙基根管密封剂的推出结合强度(PBS)的影响。方法:40颗单管牙分为4组。采用冠下法预备根管并去除涂片层后,1、2组作为对照组,3、4组以低能级二极管激光为光源,亚甲基蓝为光敏剂(MB)进行PDT治疗。1、3组用AH26密封剂填充根管,2、4组用Endoseal TCS填充根管。样品在距离尖端4、8和12 mm处切片(1mm厚的切片)。进行PBS试验,确定冠状、中间和根尖三分之一的失效模式。数据通过Kruskal-Wallis, Friedman和Dunn测试进行分析。结果:树脂基和硅酸钙基封口剂在根尖、中、冠状三分之一的PBS应用PDT时,差异无统计学意义(P>0.05)。AH26的PBS显著高于Endoseal TCS (p < 0.05)。AH26组以内聚性失效为主,Endoseal TCS组以混合性失效为主。结论:PDT对树脂基和硅酸钙基密封剂的PBS无显著影响。
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引用次数: 0
The Effect of Radiofrequency Therapy on Sexual Function in Female Cancer Survivors (Gynecologic and Breast) and Non-cancer Menopausal Women: A Single-Arm Trial. 射频治疗对女性癌症幸存者(妇科和乳腺)和非癌症更年期妇女性功能的影响:一项单臂试验。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-09-02 eCollection Date: 2023-01-01 DOI: 10.34172/jlms.2023.32
Maliheh Arab, Mahshid Vasef, Maryam Talayeh, Maryam Sadat Hosseini, Farah Farzaneh, Tahereh Ashrafganjoei

Introduction: Up to 90% of postmenopausal women and female cancer survivors may be affected by the genitourinary syndrome of menopause (GSM), with a negative impact on sexual function and quality of life. A novel energy-based device among the treatment options for GSM is radiofrequency therapy (RFT). RFT is a treatment option that uses energy from radio waves to heat the tissue. The objective of this study was to assess the impact of RFT on sexual function in female cancer survivors (gynecologic and breast) and non-cancer menopausal women. Methods: In a single-arm prospective trial, the efficacy of RFT in both female cancer survivors (gynecologic and breast) and non-cancer menopausal women with sexual dysfunction at a tertiary and referral center (Imam Hossein Medical Center, Tehran, Iran) was evaluated between April 2022 and December 2022. The study protocol consisted of 3 monthly RFT sessions. Examination was performed at baseline (T0) and 3 months after the last RFT session (T1). The primary outcome was sexual function, which was assessed using the Female Sexual Function Index (FSFI). In addition, adverse events were evaluated during treatment and at T1. Results: A total of 37 female cancer survivors (mean [SD] age: 49.4 [8.9] years) and 37 non-cancer menopausal women (mean [SD] age: 53.8 [5.5] years) were enrolled. Patients exposed to RFT showed a significant improvement in FSFI scores when compared to baseline scores for both female cancer survivors (13.07, 95% CI: 12.27 - 13.86) and non-cancer menopausal women (13.18, 95% CI: 12.34 - 14.03). There was no difference in FSFI total score improvement between the two groups (t(72)=0.06, P=0.951). There were no serious adverse events associated with RFT. Conclusion: The efficacy of RFT as a treatment for sexual dysfunction has been demonstrated in both non-cancer menopausal women and female cancer survivors. In both groups, a significant improvement was confirmed.

简介:高达90%的绝经后妇女和癌症女性幸存者可能受到更年期泌尿生殖综合征(GSM)的影响,对性功能和生活质量产生负面影响。在GSM的治疗选择中,一种新型的基于能量的设备是射频治疗(RFT)。RFT是一种利用无线电波能量加热组织的治疗选择。本研究的目的是评估RFT对女性癌症幸存者(妇科和乳腺)和非癌症更年期妇女性功能的影响。方法:在一项单臂前瞻性试验中,评估了RFT在2022年4月至2022年12月期间在三级和转诊中心(伊朗德黑兰Imam Hossein医疗中心)对癌症女性幸存者(妇科和乳腺)和性功能障碍的非癌症更年期妇女的疗效。研究方案包括3个月的RFT会议。在基线(T0)和最后一次RFT治疗后3个月(T1)进行检查。主要结果是性功能,使用女性性功能指数(FSFI)进行评估。此外,在治疗期间和T1时对不良事件进行了评估。结果:共有37名癌症女性幸存者(平均[SD]年龄:49.4[8.9]岁)和37名非癌症更年期女性(平均[SS]年龄:53.8[5.5]岁)入选。与癌症女性幸存者(13.07,95%CI:12.27-13.86)和非癌症更年期女性(13.18,95%CI:12.34-14.03)的基线评分相比,接受RFT的患者的FSFI评分显著改善。两组的FSFI总分改善无差异(t(72)=0.06,P=0.951)。没有与RFT相关的严重不良事件。结论:RFT作为治疗性功能障碍的有效性已在非癌症更年期妇女和女性癌症幸存者中得到证实。在两组中,都证实了显著的改善。
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引用次数: 0
Different Effects of Low-Level Laser Therapy on the Proliferation of HT29 Cells in Culture and Xenograft Models. 低水平激光治疗对培养和异种移植模型中HT29细胞增殖的不同影响。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-08-30 eCollection Date: 2023-01-01 DOI: 10.34172/jlms.2023.31
Najmeh Malekzadeh Gonabadi, Mehdi Shamsara, Dor Mohammad Kordi Tamandani, Sahar Shojaei, Seyed Mehdi Alavi

Introduction: Different kinds of treatments have been developed to fight cancers. Low-level laser therapy (LLLT), also known as photobiomodulation therapy (PBMT), is a low-power monochromatic and coherent light that has been used successfully for healing injuries and combating malignancies. However, there are concerns about the application of LLLT to cancers due to the increased proliferation of some cancer cells after LLLT. Methods: This study investigated the effects of 650 nm and 870 nm lasers on the proliferation of HT29 colorectal cancer cell lines in vitro and in vivo. Results: The results showed that the laser with a wavelength of 870 nm did not meaningfully alter the proliferation of cultured cells. However, cell proliferation was promoted when the laser was applied within a wavelength of 650 nm. Treatment of HT29-derived tumors in nude mice with the 650 nm laser resulted in the decline of the tumor progression rate compared to controls. This result was inconsistent with the proliferative effects of the laser on the cultured cells. Conclusion: Cell behavior in response to LLLT might be different between cell culture and xenograft models.

引言:已经开发出不同种类的治疗方法来对抗癌症。低水平激光治疗(LLLT),也称为光生物调制治疗(PBMT),是一种低功率单色相干光,已成功用于治疗损伤和对抗恶性肿瘤。然而,由于LLLT后一些癌症细胞的增殖增加,人们担心LLLT在癌症中的应用。方法:研究650nm和870nm激光对HT29结直肠癌癌症细胞株体内外增殖的影响。结果:波长870 nm的激光对培养细胞的增殖没有明显的影响。然而,当在650nm的波长内施加激光时,促进了细胞增殖。与对照组相比,用650nm激光在裸鼠中治疗HT29衍生的肿瘤导致肿瘤进展率下降。这一结果与激光对培养细胞的增殖作用不一致。结论:细胞培养和异种移植物模型对LLLT的反应可能不同。
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引用次数: 0
Comparison of Wavelength-Dependent Penetration Depth of 532 nm and 660 nm Lasers in Different Tissue Types. 532nm和660nm激光在不同组织类型中波长相关穿透深度的比较。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-08-29 eCollection Date: 2023-01-01 DOI: 10.34172/jlms.2023.28
Ali A Aldalawi, Nursakinah Suardi, Naser Mahmoud Ahmed, Mahdi A S Al-Farawn, Mohammed Ali Dheyab, Wisam I Jebur, Faisal J Kadhim

Introduction: The depth of laser light penetration into tissue is a critical factor in determining the effectiveness of photodynamic therapy (PDT). However, the optimal laser light penetration depth necessary for achieving maximum therapeutic outcomes in PDT remains unclear. This study aimed to assess the effectiveness of laser light penetration depth at two specific wavelengths, 532 nm and 660 mm. Methods: Chicken and beef of different thicknesses (1, 3, 5, 10, and 20 mm±0.2 mm) were used as in vitro tissue models. The samples were subjected to irradiation by a low-level laser diode of 532 and 660 nm in continuous mode for 10 minutes. with power densities of 167 and 142 J/cm2, respectively. Laser light transmission through the tissue was measured using a power meter. Results: For beef samples, the 660 nm wavelength achieved a maximum transmission intensity of 30.7% at 1 cm thickness, while the 532 nm laser had a transmission intensity of 6.5%. Similarly, in chicken breast samples, the maximum transmission occurred at 1 cm thickness with 68.1% for the 660 nm wavelength and 18.2% for the 532 nm laser. Conclusion: Results consistently demonstrated a significant correlation (P<0.05) between tissue thickness and laser light penetration. Thicker tissues exhibited faster declines in light transmission intensity compared to thinner tissues within 10 minutes. These findings highlight the importance of further research to enhance light delivery in thicker tissues and improve the efficacy of PDT in various medical conditions.

引言:激光穿透组织的深度是决定光动力疗法(PDT)有效性的关键因素。然而,在PDT中实现最大治疗效果所需的最佳激光穿透深度仍不清楚。本研究旨在评估激光在532 nm和660 mm两个特定波长下穿透深度的有效性。方法:使用不同厚度(1、3、5、10和20 mm±0.2 mm)的鸡肉和牛肉作为体外组织模型。样品在连续模式下经受532和660nm的低电平激光二极管的照射10分钟。功率密度分别为167和142J/cm2。使用功率计测量通过组织的激光透射。结果:对于牛肉样品,660nm波长在1cm厚度处实现了30.7%的最大透射强度,而532nm激光的透射强度为6.5%。类似地,在鸡胸肉样品中,最大透射发生在1cm厚处,660 nm波长为68.1%,532nm激光为18.2%。结论:结果一致显示出显著的相关性(P
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引用次数: 0
Combination of Fractional Er:YAG Laser, Pulsed Dye Laser, and Intralesional Triamcinolone With 5-Fluorouracil for Keloid Treatment. 部分Er:YAG激光、脉冲染料激光和病灶内曲安奈德联合5-氟尿嘧啶治疗瘢痕疙瘩。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-08-29 eCollection Date: 2023-01-01 DOI: 10.34172/jlms.2023.30
Bonnie Yudistha Anggawirya, Putri Hendria Wardhani, Diah Mira Indramaya, Muhammad Yulianto Listiawan

Introduction: Benign fibroproliferative scars that are larger than the initial lesion are called keloids. Keloids treatment in clinical practice is still difficult. Although there are various therapy choices, none is embraced by everyone or is relapse-free. Various treatment modalities such as intralesional corticosteroid injection with 5-fluorouracil (5-FU), fractional Er:YAG laser, pulsed dye laser (PDL), and others can be used either as monotherapies or combined therapies. Therefore, efforts should be made to select the treatment that will provide the best results. Case Presentation: A 6-year-old boy with keloids on the lower lips extending to the chin was successfully treated with a 2940-nm fractional Er:YAG laser alternated with a 595-nm long-PDL followed by the combined intralesional injection of corticosteroid and 5-FU. The patient was followed up for 1 year with no lesion recurrence. Conclusion: Our case supports a combined therapy to successfully treat a patient with a keloid on the chin. Therapy using a combination of these four modalities seems safe and effective and may have a synergistic effect with minimal downtime.

简介:良性纤维增生性瘢痕大于初始病变称为瘢痕疙瘩。瘢痕疙瘩的治疗在临床实践中仍然很困难。尽管有各种各样的治疗选择,但没有一种是每个人都接受的,也没有复发的。多种治疗方式,如病灶内皮质类固醇注射5-氟尿嘧啶(5-FU)、部分Er:YAG激光、脉冲染料激光(PDL)等,可作为单一疗法或联合疗法使用。因此,应努力选择能提供最佳效果的治疗方法。病例介绍:一名6岁男孩的下嘴唇瘢痕疙瘩一直延伸到下巴,他成功地用2940 nm的分段Er:YAG激光和595 nm长的PDL交替治疗,然后在病变内联合注射皮质类固醇和5-FU。患者随访1年,无复发。结论:我们的病例支持联合治疗成功治疗下巴瘢痕疙瘩患者。使用这四种模式的组合治疗似乎是安全有效的,并且可能具有协同效应,停机时间最小。
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引用次数: 0
A Good Craftsperson Knows Their Tools: Understanding of Laser and Ureter Mechanics in Training Urologists. 一个好的工匠知道他们的工具:在培训泌尿科医生时理解激光和输尿管力学。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-08-29 eCollection Date: 2023-01-01 DOI: 10.34172/jlms.2023.29
Sorcha O'Meara, Stefanie Croghan, Fergal J O'Brien, Niall F Davis

Introduction: Recent decades have seen a move to minimally invasive techniques to manage urolithiasis. Trainees are expected to develop competency in common endourology procedures. Knowledge of ureter mechanics and the theory behind new technologies is important to ensure safe and efficient techniques. We aim to evaluate the exposure to endourology, self-reported competency in common techniques and knowledge of basic ureter biomechanics and technology in training urologists. Methods: An online survey was circulated to all training urologists in the Republic of Ireland. Questions focused on self-reported competency, clinical knowledge, ureter mechanical properties and laser technology. Results: Thirty responses were received with a range of 1-8 years of urology experience (mean=4 years). The respondents reported high levels of exposure to endourology with the majority reporting competency in flexible ureterorenoscopy (FURS) (n=18, 60%) and semi-rigid ureteroscopy (URS) (n=21, 70%). The respondents demonstrated good clinical knowledge but variable knowledge of laser settings, laser thermodynamics and ureter mechanics. Half of the respondents (n=15, 50%) correctly described fragmentation laser settings, with 10 trainees (n=33%) accurately identifying both factors that increase ureteral access sheath (UAS) insertion force. Most of the respondents (n=20, 67%) described the proximal ureter as the site with the greatest compliance, while the site of the greatest force during ureteroscope insertion was correctly identified by 17% (n=5). Conclusion: To our knowledge, this represents the first study evaluating urologist understanding of laser technology and the mechanical properties of the human ureter. Despite trainees reporting high levels of experience in endourology, there is a variable understanding of the principles of laser technology and ureter mechanics. Further research and education are needed with a focus on laser safety, suitable laser settings and the safe limit of insertion forces.

引言:近几十年来,微创技术已经开始应用于治疗尿石症。受训者应具备普通泌尿外科手术的能力。输尿管力学知识和新技术背后的理论对于确保技术的安全性和有效性非常重要。我们的目的是评估接受腔内泌尿外科的情况、自我报告的常用技术能力以及基本输尿管生物力学和泌尿科医生培训技术的知识。方法:向爱尔兰共和国所有接受培训的泌尿科医生分发一份在线调查。问题集中在自我报告的能力、临床知识、输尿管机械特性和激光技术。结果:收到30份回复,有1-8年泌尿外科经验(平均=4年)。受访者报告了高水平的腔内泌尿外科暴露,大多数人报告了柔性输尿管肾镜检查(FURS)(n=18,60%)和半刚性输尿管镜检查(URS)(n=21,70%)的能力。受访者表现出良好的临床知识,但在激光设置、激光热力学和输尿管力学方面的知识参差不齐。一半的受访者(n=15,50%)正确描述了碎片激光设置,10名受训者(n=33%)准确识别了增加输尿管入鞘(UAS)插入力的两个因素。大多数受访者(n=20,67%)将输尿管近端描述为顺应性最强的部位,而输尿管镜插入过程中受力最大的部位被17%(n=5)正确识别。结论:据我们所知,这是第一项评估泌尿科医生对激光技术和人类输尿管力学性能理解的研究。尽管受训者报告说他们在腔内泌尿外科有很高的经验,但对激光技术和输尿管力学原理的理解却各不相同。需要进一步的研究和教育,重点是激光安全、合适的激光设置和插入力的安全极限。
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Journal of lasers in medical sciences
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