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The Hungry Side of Skin 皮肤饥饿的一面
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-30 DOI: 10.1016/j.jid.2024.04.030
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引用次数: 0
Immune Landscape within Cutaneous Lesions of Human Bullous Pemphigoid 人类大疱性类天疱疮皮肤病变中的免疫格局
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-22 DOI: 10.1016/j.jid.2024.04.008
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引用次数: 0
Childhood Obesity, Weight Change, and Pediatric Immune-Mediated Skin Diseases 儿童肥胖症、体重变化和小儿免疫性皮肤病。
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.01.037

Whether childhood obesity or weight gain leads to the development of pediatric immune-mediated skin diseases remains unclear. We aimed to determine the associations between body mass index or body mass index changes and the development of 3 main immune-mediated skin diseases—alopecia areata, atopic dermatitis (AD), and psoriasis—by analyzing a longitudinal cohort of 2,161,900 Korean children from 2009 to 2020. The findings indicated that children who were obese had a higher risk of pediatric immune-mediated skin diseases than those with normal weight (P for trend < .01). An increase in body mass index was associated with a higher risk of AD, whereas a decrease in body mass index was correlated with a reduced risk of AD. Children who gained weight, transitioning from normal to overweight, exhibited a higher AD risk than those who maintained a normal weight (adjusted hazard ratio = 1.15, 95% confidence interval = 1.11–1.20). However, those who shifted from being overweight to achieving a normal weight (adjusted hazard ratio = 0.87, 95% confidence interval = 0.81–0.94) had a lower AD risk than children who were overweight who maintained their weight. In summary, early childhood obesity may increase the risk of pediatric immune-mediated skin diseases. Weight gain may increase AD risk, whereas weight loss may lower the risk.

儿童肥胖或体重增加是否会导致小儿免疫介导性皮肤病的发生仍不清楚。我们旨在通过分析2009年至2020年期间216.19万名韩国儿童的纵向队列，确定身体质量指数或身体质量指数变化与3种主要免疫介导型皮肤病--斑秃、特应性皮炎（AD）和银屑病--发病之间的关系。研究结果表明，与体重正常的儿童相比，肥胖儿童患小儿免疫介导性皮肤病的风险更高（趋势 P < .01）。体重指数的增加与罹患免疫介导性皮肤病的风险升高有关，而体重指数的降低则与罹患免疫介导性皮肤病的风险降低有关。与保持正常体重的儿童相比，体重增加、从正常体重过渡到超重的儿童患注意力缺失症的风险更高（调整后危险比 = 1.15，95% 置信区间 = 1.11-1.20）。然而，与体重保持正常的超重儿童相比，那些从超重转变为体重正常的儿童（调整后危险比=0.87，95%置信区间=0.81-0.94），其患注意力缺失症的风险较低。总之，儿童早期肥胖可能会增加患小儿免疫介导的皮肤病的风险。体重增加可能会增加AD风险，而体重减轻可能会降低风险。
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引用次数: 0
Editors’ Picks 编辑推荐
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.07.002
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引用次数: 0
Clinical Snippets 临床片段
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.07.003
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引用次数: 0
Subscription Information 订阅信息
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-21 DOI: 10.1016/S0022-202X(24)01930-4
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引用次数: 0
Montagna Symposium on the Biology of Skin 70th Anniversary: Visualizing the Future! 蒙塔格纳皮肤生物学研讨会 70 周年：展望未来！
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.04.001
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引用次数: 0
032 Non-classical presentation of IL-6 to endothelial cells (ECs) biases the outcome of antigen presentation by Langerhans cells (LCs) to CD4 T cells away from an IFNγ response and toward an IL-17A response 032 IL-6 向内皮细胞（ECs）的非典型呈递使朗格汉斯细胞（LCs）向 CD4 T 细胞呈递抗原的结果偏离 IFNγ 反应，而转向 IL-17A 反应
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.048
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引用次数: 0
034 Downregulation of Ebp1Khib210 promotes keratinocyte proliferation through induction of TIF-IA-mediated rRNA synthesis 034 下调 Ebp1Khib210 可通过诱导 TIF-IA 介导的 rRNA 合成促进角质形成细胞增殖
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.050
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引用次数: 0
056 Translational application of IL-37-expressing Treg cells in inflammation and immunity 056 表达 IL-37 的 Treg 细胞在炎症和免疫中的转化应用
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.072
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引用次数: 0
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