Journal of Multidisciplinary Healthcare最新文献

Background: The psychosocial impact of cancer, particularly social isolation, has gained increasing recognition in oncology research. This bibliometric analysis maps the global research landscape and evolving trends in social isolation among cancer patients over two decades.

Methods: We retrieved original research articles and review papers on cancer research associated with social isolation from Web of Science database between 2005 and 2024. Utilizing bibliometric platforms such as CiteSpace, VOSviewer, and bibliometric websites, we analyzed the annual publication trends, leading journals, countries, institutions, and authors in this field. Additionally, by analyzing keyword visualizations and keyword bursts, we identified the emerging and popular research areas related to social isolation in cancer research.

Results: We systematically analyzed 1219 publications from 2005 to 2024. Globally, the United States accounted for the highest proportion of research output (34.78%), ahead of England (16.57%) and China (7.71%). In terms of institutional contributions, the top three positions were held by the University of London (58 publications), the University of California System (54 publications) and French National Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale, INSERM; 52 publications). Supportive Care in Cancer was the journal with the highest number of publications (52 papers). Keyword co-occurrence analysis revealed six major research clusters: social deprivation, palliative care, social isolation, social support, physical activity, and cognitive function. The research focus is transitioning from "risk factors" (2005-2014) to "psychosocial interventions" (2015-2024), with emerging focus on disparities, social determinants of health, and symptom management.

Conclusion: This study reveals accelerating global interest in cancer-related social isolation and highlights the need for multidisciplinary approaches that integrate biological and psychosocial perspectives in cancer survivorship care, particularly through targeted interventions for vulnerable populations.

Background: Chronic insomnia is a prevalent health concern. Treatment methods for chronic insomnia encompass medication therapy, psychotherapy, physical therapy, and sympathetic nerve regulation therapy. The synergistic effects of these various therapeutic approaches warrant further investigation.

Objective: This study aims to evaluate the impact of cognitive behavioral therapy for insomnia (CBT-I) in conjunction with stellate ganglion block (SGB) treatment on patients suffering from chronic insomnia.

Patients and methods: Patients diagnosed with chronic insomnia who were admitted to the anesthesia outpatient department between January 2023 and September 2024 were selected for this study. They were divided into two groups: the SGB group (Group S) and the CBT-I combined with SGB group (Group CS). Group S received ultrasound-guided SGB using 0.375% ropivacaine at a volume of 4 mL alternately on both sides, administered twice weekly over a period of 6 weeks. Group CS underwent CBT-I concurrently with SGB following the same protocol as Group S for 6 weeks. The Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and hypnotic medication were recorded before treatment as well as at 6 weeks and 12 weeks after treatment.

Results: The ISI and ESS scores were significantly decreased than before treatment at 6 weeks after treatment in group S (P < 0.05), and the ISI and ESS scores were significantly decreased than before treatment at 6 and 12 weeks after treatment in group CS (P < 0.05). The ISI and ESS scores were significantly lower in group CS than in group S at 6 and 12 weeks after treatment (P < 0.05). The hypnotic medication was also significantly lower in group CS than in group S at 12 weeks after treatment (P < 0.05).

Conclusion: CBT-I substantially enhances the efficacy of stellate ganglion block treatment for chronic insomnia, reducing reliance on hypnotic medications; furthermore, sustains stable long-term outcomes.

Objective: To identify distinct sleep quality profiles among patients undergoing maintenance hemodialysis (MHD) using latent profile analysis (LPA), and examine differences in perceived stigma across these sleep quality subtypes.

Methods: From December 2024 to March 2025, a total of 334 MHD patients were recruited via convenience sampling from the nephrology departments of two tertiary hospitals in Xinjiang, China. Data were collected using structured questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Depression Scale (SDS), and the Social Impact Scale (SIS), along with sociodemographic and clinical information. LPA was employed to identify latent subgroups of sleep quality based on PSQI components. Multinomial logistic regression was used to determine predictors of sleep profile membership. Differences in stigma scores across sleep profiles were analyzed using non-parametric equivalents.

Results: Three distinct sleep profiles were identified: Class 1 - "overall better sleep", Class 2 - "short sleep duration and low efficiency", and Class 3 - "poor sleep quality with high medication use". Multinomial logistic regression identified comorbid heart failure (OR=2.867, P=0.001 for Class 2), pruritus (OR=2.715, P<0.001 for Class 2), depressive symptoms (OR=2.568, P=0.001 for Class 2; OR=4.823, P<0.001 for Class 3), and elevated C-reactive protein (OR=1.044, P<0.001 for Class 2; OR=1.035, P=0.008 for Class 3) as significant predictors of poorer sleep profiles. Stigma scores differed significantly across all sleep profiles (Class 1 vs 2: P=0.039; Class 1 vs 3: P<0.001; Class 2 vs 3: P=0.005), with Class 3 exhibiting the highest median SIS score.

Conclusion: Patients with MHD exhibit heterogeneous patterns of sleep disturbance, which are associated with varying levels of perceived stigma. Those with the poorest sleep quality and highest reliance on medication experience the most pronounced stigma. Tailored interventions addressing sleep-related issues and psychosocial factors may help reduce stigma and improve patient well-being.

Objective: The high prevalence of anxiety disorders among heart failure (HF) patients significantly impacts clinical outcomes, yet a comprehensive analysis of the global research landscape is lacking. This study explores research trends, knowledge structure, and emerging hotspots in the field of HF and anxiety comorbidity over the past decade.

Methods: A bibliometric analysis was conducted on 1,475 publications from the Web of Science Core Collection (2015-2024). A total of 1,475 English-language publications, including articles and reviews, were analyzed. CiteSpace and VOSviewer were used to analyze collaboration networks, references, and keywords. The search tool for the retrieval of interacting genes database was applied to construct a protein-protein interaction (PPI) network of HF and anxiety comorbidity. R with clusterProfiler was applied to perform kyoto encyclopedia of genes and genomes pathway enrichment analysis. Cytoscape was applied to visualize both the PPI network and the significant pathways.

Results: Annual publications increased steadily, peaking in 2021. The United States of America and China emerged as the most productive countries. Key contributors included Linkoping University and Harvard Medical School. Keyword analysis revealed evolving focuses from mortality and depression to self-care, cardiac rehabilitation, and psychological assessment tools. Gene intersection analysis identified 124 shared genes, with hub genes such as AKT1, TP53, and IL6 implicated in MAPK, FoxO, and JAK-STAT signaling pathways. These results suggest neuroendocrine and inflammatory mechanisms linking HF and anxiety.

Conclusion: This study offers the bibliometric and molecular insight into the HF and anxiety comorbidity landscape. While research output and mechanistic understanding have grown, gaps remain in standardized assessment and clinical translation. Future studies should focus on translating these mechanistic insights into strategies that improve integrated care and quality of life for patients living with the dual burden of heart failure and anxiety.

Pharmacogenetics is a concept designed to tailor medication based on genetic profile to improve efficacy and reduce adverse effects. This personalized strategy shows considerable potential for populations facing complicated therapeutic challenges, such as the coinfected Tuberculosis (TB)-HIV population. This systematic review analyses pharmacogenes related to antiretroviral and anti-tuberculosis medications in the TB-HIV population. An analysis of 39 included studies indicated that efavirenz and CYP2B6*6 are the most extensively researched antiretroviral therapy (ART) and gene, respectively. Isoniazid and N-acetyltransferase 2 (NAT2) are the most extensively researched anti-TB drug and gene, respectively. Nevertheless, many studies relied solely on observational research and the investigation of pharmacokinetic characteristics. Research evaluated both the drug concentration of individual gene-drug interactions and the interactions between medications based on their genotypes. The NAT2 slow acetylator genotype is associated with elevated isoniazid levels, consequently increasing efavirenz plasma concentrations. Arylacetamide deacetylase (AADAC) polymorphisms that increased rifapentine plasma levels could also reduce dolutegravir plasma concentrations. Specific genes linked to significant outcomes in TB-HIV populations, such as pregnane X receptor (PXR) g.24087C>T, which increased the mortality rate. Consequently, a holistic approach to pharmacogenetics in TB-HIV populations is essential, considering all drug-gene-disease interactions. High-quality research, including randomized controlled trials (RCTs), is necessary for the implementation of pharmacogenetic testing in TB-HIV populations before it can be widely adopted in clinical practice, which is currently lacking.

Purpose: Osteoporotic vertebral compression fractures (OVCFs) pose significant challenges in healthcare, and percutaneous kyphoplasty (PKP) has emerged as a key treatment option. This study aimed to identify and analyze research trends on PKP and OVCFs through a comprehensive bibliometric analysis.

Patients and methods: A literature search on PKP and OVCFs was conducted using the Web of Science Core Collection, finalized on March 21, 2025. The analysis employed bibliometric tools including VOSviewer, CiteSpace, and the R package "bibliometrix".

Results: A total of 381 articles published from 2002 to 2025 were included in this study. These publications were authored by 1739 researchers affiliated with 486 institutions across 28 countries. The journals Spine and European Spine Journal were prominent in terms of citations. China emerged as the leading contributor, ranking first in both total publications (265) and citations (3599). Soochow University was identified as the most productive institution. Yang HL was the most influential author, ranking first in total publications (22) and accumulating the highest total citation count of 483. The keyword "bone cement" was a frequently occurring term. The keywords "bone cement distribution" (2022-2025) and "volume" (2023-2025) were observed to undergo significant bursts of activity.

Conclusion: This bibliometric study highlighted the growing global interest in PKP and OVCFs research, with China as a leading contributor. The research focus has evolved to emphasize procedural safety, material optimization, and patient-centered outcomes. These findings provide valuable insights for guiding future research and informing evidence-based treatment strategies.

Purpose: Upper tract urothelial carcinoma (UTUC) is a rare malignant tumor of the urinary tract. Understanding this complex condition requires insights from multiple disciplines, including urology, oncology, molecular biology, genetics, and immunology. The objective of this study was to identify research trends and emerging research hotspots in UTUC research by using bibliometric analysis.

Methods: UTUC publications were retrieved from the Web of Science Core Collection (WoSCC) on 8 December 2024 and analyzed with VOSviewer and CiteSpace to assess trends, collaborations, and research hotspots, with emphasis on the top 50 citation bursts.

Results: This study analyzed 3,226 publications on UTUC from 1998 to 2024, revealing a consistent upward trend in both annual publication output and citation frequency. The United States emerged as the leading country in terms of publication volume, total citations, and international collaboration intensity. Among research institutions, the Medical University of Vienna published the highest number of publications, while the University of Texas MD Anderson Cancer Center achieved the highest H-index. Meanwhile, Pierre and Marie Curie University led in average citations per publication. Shahrokh F. Shariat was identified as the most prolific author, excelling in both citation count and H-index. Urologic Oncology: Seminars and Original Investigations ranked highest in publication volume, whereas European Urology demonstrated the strongest academic impact. Keyword analysis indicated shifting research hotspots over time, with growing interest in kidney-sparing surgery, biomarker, neo/adjuvant therapies, and multicenter clinical trials, signaling potential future directions for UTUC research.

Conclusion: Our bibliometric analysis provides an overview of current UTUC research trends and emerging topics, which may help researchers identify areas for further investigation.

Chronic headache (CH) is a leading cause of debilitating disorders, with many headache types remaining undiagnosed due to improper medication use. This misuse not only worsens the underlying condition but also leads to a secondary problem: medication overuse headache (MOH). This creates a cycle of increasingly complex headache cases, posing significant challenges for patients, healthcare providers, and the healthcare system as a whole. Physicians often contribute to this issue by prescribing analgesics without proper assessment or adequately educating patients on their correct use, thereby increasing the risk of MOH. However, MOH is a preventable condition. Prevention relies on educating both healthcare providers-through adherence to headache management guidelines-and patients, empowering them to use medications appropriately. This article provides a comprehensive review of the consequences of overprescription analgesics for CH population, and effective prevention strategies to mitigate its impact.

Background: Immigrants' health education (IHE) plays a critical role in improving the health status of immigrant populations, reducing public health risks, and promoting social integration. Over the past decade, IHE has emerged as a prominent research topic, with numerous studies exploring its specific characteristics; however, comprehensive overviews remain scarce. A detailed and systematic synthesis is needed to better understand the knowledge structure, thematic evolution, current research hotspots, and emerging trends in IHE.

Methods: A bibliometric approach was adopted to analyze the knowledge structure, collaborative relationships, research status, and developmental trends in IHE. CiteSpace was used as the tool; the study further constructed a comprehensive knowledge framework for IHE, identifying future research directions and enhancing understanding of the field.

Results: IHE research has developed rapidly, with 2984 publications over the past 20 years. Despite the complexity of regional and institutional collaborations, the United States has taken a leading role, accounting for 1196 regional collaborations with a centrality score of 0.2. Institutionally, the University of California System led with 196 collaborations. Journals with high co-citation frequencies generally showed higher impact factors; for instance, Social Science & Medicine was co-cited 1212 times with an impact factor (IF) of 5.2, and only two of the top ten journals had a 5-year IF below 3. IHE research includes medicine, education, and public health. The emergence of keywords such as "social determinants of health", "overweight", and "health equity" highlights the field's increasing specialization.

Conclusion: Over the past twenty years, IHE publications have increased significantly, spanning various journal categories and journals. While institutional and regional collaborations were relatively strong, the authors conducted research independently. The findings indicate that IHE remains rich in research opportunities. Moreover, the results of this study offer a theoretical foundation for policymakers and a guide for advancing interdisciplinary practices in IHE.

Background: The Healthy Community Clinics Program, launched by the Royal Health Awareness Society in partnership with the Ministry of Health, aims to strengthen primary health centers' capacity for preventive care and support patients in managing non-communicable diseases.

Aim: This study explores patient experiences in improving self-management through education, counseling, and support provided by healthcare providers at Healthy Community Clinics.

Methods: A qualitative study design was used to conduct semi-structured telephone interviews with 100 patients living with Non-Communicable Diseases from three regions of Jordan (North, Central/middle, South), covering 12 governorates.

Results: Thematic analysis identified three themes: patients' perceptions of the program's impact on their lives; factors influencing engagement and adherence; and experiences with healthcare providers.

Conclusion: The findings suggest the Healthy Community Clinics program positively influenced patients' health behaviors, lifestyle choices, and satisfaction with care.