Pub Date : 2019-05-01DOI: 10.26655/JMCHEMSCI.2019.4.8
M. Nabati, Hamideh Sabahnoo
The main aim of the present work is theoretical studies and docking analysis on the novel small molecule irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines. The quantum mechanical computations are done using B3LYP/6-31+G(d,p) level of theory on the molecule under study at room temperature. The theoretical calculations showed that irilone is a stable small molecule with high electrophilicity property. The density of states (DOS) graph indicated that the virtual orbitals of the said compound have more density than the occupied orbitals. These studied indicated that the title compound can make a complex with progesterone receptor (PR) using steric and hydrogen bond (HB) interactions. The docking analysis showed that the receptor (PR-B isoform) residues Pro-696, Gln-725, Met-759, Arg-766, Glu-695, Asp-697, Leu-758, Lys-822, Ile-699, Val-698 and Trp-755 play main role in receptor-ligand complex formation.
{"title":"Spectroscopic (FT-IR and UV-Vis), electronic and docking studies on the red clover isoflavone irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines","authors":"M. Nabati, Hamideh Sabahnoo","doi":"10.26655/JMCHEMSCI.2019.4.8","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.4.8","url":null,"abstract":"The main aim of the present work is theoretical studies and docking analysis on the novel small molecule irilone as a progesterone receptor (PR) effect supporter in endometrial and ovarian cancer cell lines. The quantum mechanical computations are done using B3LYP/6-31+G(d,p) level of theory on the molecule under study at room temperature. The theoretical calculations showed that irilone is a stable small molecule with high electrophilicity property. The density of states (DOS) graph indicated that the virtual orbitals of the said compound have more density than the occupied orbitals. These studied indicated that the title compound can make a complex with progesterone receptor (PR) using steric and hydrogen bond (HB) interactions. The docking analysis showed that the receptor (PR-B isoform) residues Pro-696, Gln-725, Met-759, Arg-766, Glu-695, Asp-697, Leu-758, Lys-822, Ile-699, Val-698 and Trp-755 play main role in receptor-ligand complex formation.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88989141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.26655/JMCHEMSCI.2019.4.4
A. Saraçoğlu, Ş. Tetik
Trauma is a common cause of death in developed countries leading trauma related coagulopathy. In recent years, ‘new type endothelium development’ caused by trauma-induced hemorrhagic shock, have been widely understood and researchers try to figure out the effect of endothelial apoptosis on this process. New modulation of immune response may result in undesired apoptosis and give rise to programmed cell death. In experimental models, apoptosis has been shown in liver, kidney, heart and brain after the damage of ischemia/reperfusion (I/R) during trauma. Apoptosis may be an important factor for the development of serious hemorrhagic shock during trauma. In this review we aimed to reveal the possible relationship between trauma and apoptosis.
{"title":"Trauma-induced Apoptosis of Endothelial Cells","authors":"A. Saraçoğlu, Ş. Tetik","doi":"10.26655/JMCHEMSCI.2019.4.4","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.4.4","url":null,"abstract":"Trauma is a common cause of death in developed countries leading trauma related coagulopathy. In recent years, ‘new type endothelium development’ caused by trauma-induced hemorrhagic shock, have been widely understood and researchers try to figure out the effect of endothelial apoptosis on this process. New modulation of immune response may result in undesired apoptosis and give rise to programmed cell death. In experimental models, apoptosis has been shown in liver, kidney, heart and brain after the damage of ischemia/reperfusion (I/R) during trauma. Apoptosis may be an important factor for the development of serious hemorrhagic shock during trauma. In this review we aimed to reveal the possible relationship between trauma and apoptosis.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84007430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.26655/JMCHEMSCI.2019.8.6
Danjatau W. Dogo, H. Louis, Nkafamiya I. Iliya, Akakuru U. Ozioma, Adeleye T. Aderemi, Barminas Stware
The swelling kinetics of charantin from poly (N-isopropyl acrylamide), PNIPAM–based hydrogel, is accomplished through direct weighing, before soaking the gel in fluid/drug solution at controlled temperatures inside a temperature-controlled water bath. The investigation was carried out for application as anti-diabetic drug delivery system. Charantin was extracted from bitter melon fruit and leaf under a controlled pH of 4.5. The preparation of PNIPAM was done by varying the acrylamide between (3-12)% and show increase in the lower critical solution temperature (LCST) from 32- 43℃ which indicates a direct relationship in distilled water. The effect of changing solution from distilled water, insulin, and charantin solution, shows that the higher the polarity of the solution, the lower the LCST of the hydrogel. Charantin loaded on hydrogels N1, N2, N3, and N4 were found to be (42.51, 44.57, 43.55 and 44.61)μg/mL, respectively, when soaked in charantin solution of 52.61 μg/mL. Characterization of the hydrogels using Fourier transformed infrared (FTIR) spectroscopy shows that there is physical interaction between the hydrogel matrix and the charantin molecules. The diffusivity of the hydrogels ranged from 1.48 x 10-10 to 5.08 x 10-8 M2/s and their release exponents were ≥ 0.5 indicative of non-Fickian difusional release.
{"title":"Swelling Kinetics of Poly(N-Isopropylacrylamide)-Based Hydrogel and its Application as Anti-Diabetic Drugs Delivery System","authors":"Danjatau W. Dogo, H. Louis, Nkafamiya I. Iliya, Akakuru U. Ozioma, Adeleye T. Aderemi, Barminas Stware","doi":"10.26655/JMCHEMSCI.2019.8.6","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.8.6","url":null,"abstract":"The swelling kinetics of charantin from poly (N-isopropyl acrylamide), PNIPAM–based hydrogel, is accomplished through direct weighing, before soaking the gel in fluid/drug solution at controlled temperatures inside a temperature-controlled water bath. The investigation was carried out for application as anti-diabetic drug delivery system. Charantin was extracted from bitter melon fruit and leaf under a controlled pH of 4.5. The preparation of PNIPAM was done by varying the acrylamide between (3-12)% and show increase in the lower critical solution temperature (LCST) from 32- 43℃ which indicates a direct relationship in distilled water. The effect of changing solution from distilled water, insulin, and charantin solution, shows that the higher the polarity of the solution, the lower the LCST of the hydrogel. Charantin loaded on hydrogels N1, N2, N3, and N4 were found to be (42.51, 44.57, 43.55 and 44.61)μg/mL, respectively, when soaked in charantin solution of 52.61 μg/mL. Characterization of the hydrogels using Fourier transformed infrared (FTIR) spectroscopy shows that there is physical interaction between the hydrogel matrix and the charantin molecules. The diffusivity of the hydrogels ranged from 1.48 x 10-10 to 5.08 x 10-8 M2/s and their release exponents were ≥ 0.5 indicative of non-Fickian difusional release.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82520956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-22DOI: 10.26655/JMCHEMSCI.2020.1.1
A. Alkherraz, Aisha Khalifa Ali, K. Elsherif
Adsorption of Pb(II), Zn(II), Cu(II), and Cd(II) ions onto Mesembryanthemum activated carbon in a batch experimentby taking the consideration of adsorbent particle size, initial concentration, temperature, and pH was studied. Langmuir and Freundlich isotherm models were tested to fit the equilibrium data. Freundlich isotherm model gave a better fit to our experimental data than the Langmuir model. The adsorption capacity values were 66.67, 52.63, 45.45, and 40.00 mg/g for Pb(II), Zn(II), Cu(II), and Cd(II), respectively. The ideal pH for all metal ions adsorption was at pH 5. The obtained thermodynamic parameters suggested that the adsorption process was physical, spontaneous (ΔGo 0).
{"title":"Equilibrium and thermodynamic studies of Pb(II), Zn(II), Cu(II) and Cd(II) adsorption onto mesembryanthemum activated carbon","authors":"A. Alkherraz, Aisha Khalifa Ali, K. Elsherif","doi":"10.26655/JMCHEMSCI.2020.1.1","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2020.1.1","url":null,"abstract":"Adsorption of Pb(II), Zn(II), Cu(II), and Cd(II) ions onto Mesembryanthemum activated carbon in a batch experimentby taking the consideration of adsorbent particle size, initial concentration, temperature, and pH was studied. Langmuir and Freundlich isotherm models were tested to fit the equilibrium data. Freundlich isotherm model gave a better fit to our experimental data than the Langmuir model. The adsorption capacity values were 66.67, 52.63, 45.45, and 40.00 mg/g for Pb(II), Zn(II), Cu(II), and Cd(II), respectively. The ideal pH for all metal ions adsorption was at pH 5. The obtained thermodynamic parameters suggested that the adsorption process was physical, spontaneous (ΔGo 0).","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75113965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26655/JMCHEMSCI.2019.3.5
H. Louis, Grace Kwata Fidelis, T. T. Fidelis, S. Onoshe
Curcumin which is an active component of tumeric, derived from the dried rhizome of curcuma longa plant has been known for its medicinal values in wound healing, treatment of inflammatory disease, urinary tract infections, biliary disease, and liver ailments. This medicinal property has been recently exploited in cancer prevention and therapy since extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which transcription factors, anti-apoptotic proteins, growth factor receptors and multi-drug resistance proteins are involved. In order to improve the medicinal value of curcumin in cancer prevention and therapy, novel nanoformulations of curcumin have been synthesized, ranging from nanoparticles, nanolipids, chitosan, and nanofibers. Here, the recent method of curcumin synthesis using nanotechnology and the mechanisms by which they exert their anti-cancer effects will be reviewed.
{"title":"Curcumin and Curcumin-based derivatives as anti-cancer agents: Recent Nano-Synthetic Methodologies and Anti-cancer Therapeutic Mechanisms","authors":"H. Louis, Grace Kwata Fidelis, T. T. Fidelis, S. Onoshe","doi":"10.26655/JMCHEMSCI.2019.3.5","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.3.5","url":null,"abstract":"Curcumin which is an active component of tumeric, derived from the dried rhizome of curcuma longa plant has been known for its medicinal values in wound healing, treatment of inflammatory disease, urinary tract infections, biliary disease, and liver ailments. This medicinal property has been recently exploited in cancer prevention and therapy since extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which transcription factors, anti-apoptotic proteins, growth factor receptors and multi-drug resistance proteins are involved. In order to improve the medicinal value of curcumin in cancer prevention and therapy, novel nanoformulations of curcumin have been synthesized, ranging from nanoparticles, nanolipids, chitosan, and nanofibers. Here, the recent method of curcumin synthesis using nanotechnology and the mechanisms by which they exert their anti-cancer effects will be reviewed.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88839307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26655/JMCHEMSCI.2019.3.1
E. Gomaa, M. Diab, Adel Z. El Sonbati, Hamed M Abuo Elnader, Gannat S. Abd Elraoof
Redox reaction mechanism in absence and presence of Valporic Acid (VaA) was Studied in cyclic voltammetry, we used a new silver electrode made from pure Silver piece jointed to Copper wire and isolated by heat shrink polymer to insure Complete isolation, during measurments. The Silver electrode was polished with Al2O3 in woolen piece, washed and used for the cyclic voltammetric Study. The stability constants and Gibbs free energies of Complex reactions between HgCl2 and Valproic acid (VaA) in 0.01 M KNO3 at 22˚C were evaluated and their results were discussed.
在循环伏安法中研究了Valporic Acid (VaA)不存在和不存在时的氧化还原反应机理。在测量过程中，我们使用了一种由纯银片与铜线连接而成的新型银电极，并通过热缩聚合物隔离，以确保完全隔离。将银电极用Al2O3在羊毛片上抛光，洗涤后用于循环伏安研究。测定了HgCl2与丙戊酸(VaA)在22℃、0.01 M KNO3溶液中络合反应的稳定常数和吉布斯自由能，并对其结果进行了讨论。
{"title":"Solvation Parameters for The Interaction of HgCl2 with Valporic Acid (VaA) in KNO3 Using Silver Working Electrode (Cyclic Voltammetry)","authors":"E. Gomaa, M. Diab, Adel Z. El Sonbati, Hamed M Abuo Elnader, Gannat S. Abd Elraoof","doi":"10.26655/JMCHEMSCI.2019.3.1","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.3.1","url":null,"abstract":"Redox reaction mechanism in absence and presence of Valporic Acid (VaA) was Studied in cyclic voltammetry, we used a new silver electrode made from pure Silver piece jointed to Copper wire and isolated by heat shrink polymer to insure Complete isolation, during measurments. The Silver electrode was polished with Al2O3 in woolen piece, washed and used for the cyclic voltammetric Study. The stability constants and Gibbs free energies of Complex reactions between HgCl2 and Valproic acid (VaA) in 0.01 M KNO3 at 22˚C were evaluated and their results were discussed.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89924272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26655/JMCHEMSCI.2019.3.7
E. A. Gomaa, M. Diab, A. El-Sonbati, Hamed M Abuo Elnader, A. M. Helm
he redox mechanisms were examined for Copper bromide in the absence and presence of (LC) using cyclic voltammetry. The mechanisms of reduction and oxidation were examined while using new glassy carbon electrode prepared in laboratory from pure carbon piece jointed with copper wire and isolated by heat shrink polymer to avoid contact with solutions. In order to explain the type of the used reaction in electrochemical study, the complexation stability constants and Gibbs free energies of complex formation obtained from the interaction of CuBr2 with (LC) were obtained from the experimental part and their values were discussed. The prepared galssy carbon electrode was polished with Al2O3 andput in a woolen clear piece, washed and used for cyclic voltammetry measurements.
{"title":"Electrochemical Solvation Parameters for The Interaction of CuBr2 With Carbazine 720 (LC) in NaClO4 Using Glassy Carbon working electrode (cyclic voltammetry)","authors":"E. A. Gomaa, M. Diab, A. El-Sonbati, Hamed M Abuo Elnader, A. M. Helm","doi":"10.26655/JMCHEMSCI.2019.3.7","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.3.7","url":null,"abstract":"he redox mechanisms were examined for Copper bromide in the absence and presence of (LC) using cyclic voltammetry. The mechanisms of reduction and oxidation were examined while using new glassy carbon electrode prepared in laboratory from pure carbon piece jointed with copper wire and isolated by heat shrink polymer to avoid contact with solutions. In order to explain the type of the used reaction in electrochemical study, the complexation stability constants and Gibbs free energies of complex formation obtained from the interaction of CuBr2 with (LC) were obtained from the experimental part and their values were discussed. The prepared galssy carbon electrode was polished with Al2O3 andput in a woolen clear piece, washed and used for cyclic voltammetry measurements.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74623177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26655/JMCHEMSCI.2019.3.3
Srinivasa Gupta, M. Lakshman
An efficient three-component synthesis of 2,4,5-trisubstituted imidazolesis described by one-pot condensation of aldehydes, diketones and ammonium acetate using CoFe2O4 magnetic nanoparticles as an efficient and environmentally benign catalyst.The easy recovery of the catalyst and reusability, broad substrate scopes, high yields of products and ethanol as solvent make this protocol practical, environmentally friendly and economically attractive.
{"title":"Magnetic Nano Cobalt Ferrite: An efficient recoverable catalyst for synthesis of 2,4,5-trisubstituted imidazoles","authors":"Srinivasa Gupta, M. Lakshman","doi":"10.26655/JMCHEMSCI.2019.3.3","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.3.3","url":null,"abstract":"An efficient three-component synthesis of 2,4,5-trisubstituted imidazolesis described by one-pot condensation of aldehydes, diketones and ammonium acetate using CoFe2O4 magnetic nanoparticles as an efficient and environmentally benign catalyst.The easy recovery of the catalyst and reusability, broad substrate scopes, high yields of products and ethanol as solvent make this protocol practical, environmentally friendly and economically attractive.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83305461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26655/JMCHEMSCI.2019.3.2
N. LathaL, Gyananath Garimella, Anjaneyalu Kasa, Z. Pudukulathan
Sigma-1 receptors are unique and distinct class of receptors widely expressed in the central nervous system with involvement in regulation of various neutransmitters and are often over expressed in tumor cell lines of various tissues, such as melanoma, breast cancer, small lung carcinoma and prostate cancer. Accordingly, sigma ligands display anticancer activity in- vivo and in-vitro. In the present study, an attempt has been made to validate sigma-1receptor and study its antipsychotic ligand interactions in a molecular perspective. C6 cells (rat glioma) grown in monolayers were exposed to haloperidol (sigma-1 antagonist) and other anti-psychotic ligands and their relative cytotoxicity was determined by MTT assay to be 42.79 %, 18.96 %, 24.95 and 22.72% for haloperidol, ligand 1, ligand 2 and ligand 3 respectively. Occupancy of sigma receptors with ligands through DNA laddering studies reveal the antipsychotic ligands modulate psychosis via sigma-1receptor.
{"title":"Validation of Sigma I Receptor Occupancy with Antipsychotic Ligands: A Molecular Perspective","authors":"N. LathaL, Gyananath Garimella, Anjaneyalu Kasa, Z. Pudukulathan","doi":"10.26655/JMCHEMSCI.2019.3.2","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.3.2","url":null,"abstract":"Sigma-1 receptors are unique and distinct class of receptors widely expressed in the central nervous system with involvement in regulation of various neutransmitters and are often over expressed in tumor cell lines of various tissues, such as melanoma, breast cancer, small lung carcinoma and prostate cancer. Accordingly, sigma ligands display anticancer activity in- vivo and in-vitro. In the present study, an attempt has been made to validate sigma-1receptor and study its antipsychotic ligand interactions in a molecular perspective. C6 cells (rat glioma) grown in monolayers were exposed to haloperidol (sigma-1 antagonist) and other anti-psychotic ligands and their relative cytotoxicity was determined by MTT assay to be 42.79 %, 18.96 %, 24.95 and 22.72% for haloperidol, ligand 1, ligand 2 and ligand 3 respectively. Occupancy of sigma receptors with ligands through DNA laddering studies reveal the antipsychotic ligands modulate psychosis via sigma-1receptor.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81500457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.26655/JMCHEMSCI.2019.3.4
A. Sajjadi, R. Mohammadi
In this paper, Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) were prepared and intro-duced as an efficient and eco-friendly catalyst for the synthesis of benzimidazole derivatives. The as-synthesized Fe3O4 magnetic nanoparticles were characterized by FT-IR spectroscopy and scanning electron microscopy (SEM).This method afforded the target products in high yields and the catalytic system could be recycled and reused without significant loss of catalytic activity.
{"title":"Fe3O4 magnetic nanoparticles (Fe3O4 MNPs): A magnetically reusable catalyst for synthesis of Benzimidazole compounds","authors":"A. Sajjadi, R. Mohammadi","doi":"10.26655/JMCHEMSCI.2019.3.4","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.3.4","url":null,"abstract":"In this paper, Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) were prepared and intro-duced as an efficient and eco-friendly catalyst for the synthesis of benzimidazole derivatives. The as-synthesized Fe3O4 magnetic nanoparticles were characterized by FT-IR spectroscopy and scanning electron microscopy (SEM).This method afforded the target products in high yields and the catalytic system could be recycled and reused without significant loss of catalytic activity.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83316744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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