Pub Date : 2021-07-27DOI: 10.26655/JMCHEMSCI.2021.5.2
M. Shah-abadi, M. Heydari, Ehsan Goroei Sardu
Different observational studies and randomized trials attempted to show advantages as well as limitations of surgical approaches for improvement in patients’ quality of life (QOL) suffering hyperthyroidism caused by the Graves´ disease (GD). We aimed to systematically examine the impact of surgery (thyroidectomy) on different components of QOL in patients with GD. Two reviewers began to deeply search the various databases of article published including Medline, Web of knowledge, Google Scholar, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library for all eligible studies in accordance with the considered keywords. In final, seven articles were eligible for the final analysis that published between 2012 and 2019. The Comprehensive Meta-Analysis Software was employed for analysis. Assessing the level of quality of life using SF-36 tool showed significantly increase in both physical component score (weighted mean differences of 0.428, p <0.001) and psychological component score (weighted mean differences of 0.277, p <0.001) postoperatively compared with the baseline values. The assessment of QOL using the Thy PRO questionnaire also showed significantly improvement in total QOL score after surgery compared with before that (weighted mean differences of -1.466, p <0.001). We revealed considerably improving both physical and mental aspects of QOL following surgery in Graves’ disease.
不同的观察性研究和随机试验试图显示手术方法在改善Graves病(GD)引起的甲状腺功能亢进患者生活质量(QOL)方面的优势和局限性。我们的目的是系统地研究手术(甲状腺切除术)对GD患者生活质量不同组成部分的影响。两位审稿人开始深入搜索包括Medline、Web of knowledge、Google Scholar、Scopus和Cochrane Central Register of Controlled Trials (Central)在内的Cochrane Library中已发表文章的各种数据库，根据所考虑的关键词搜索所有符合条件的研究。最终，在2012年至2019年期间发表的七篇文章有资格进行最终分析。采用综合meta分析软件进行分析。使用SF-36工具评估生活质量水平显示，与基线值相比，术后身体成分评分(加权平均差值0.428,p <0.001)和心理成分评分(加权平均差值0.277,p <0.001)均显著增加。采用Thy PRO问卷评估患者的生活质量，术后总生活质量评分较术前有显著提高(加权平均差异为-1.466,p <0.001)。我们发现格雷夫斯病手术后身体和精神方面的生活质量都有显著改善。
{"title":"Evaluation of Medicinal and Medical Effects on Quality of Life in Patients with Hyperthyroidism Due to Graves´ Disease","authors":"M. Shah-abadi, M. Heydari, Ehsan Goroei Sardu","doi":"10.26655/JMCHEMSCI.2021.5.2","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.5.2","url":null,"abstract":"Different observational studies and randomized trials attempted to show advantages as well as limitations of surgical approaches for improvement in patients’ quality of life (QOL) suffering hyperthyroidism caused by the Graves´ disease (GD). We aimed to systematically examine the impact of surgery (thyroidectomy) on different components of QOL in patients with GD. Two reviewers began to deeply search the various databases of article published including Medline, Web of knowledge, Google Scholar, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library for all eligible studies in accordance with the considered keywords. In final, seven articles were eligible for the final analysis that published between 2012 and 2019. The Comprehensive Meta-Analysis Software was employed for analysis. Assessing the level of quality of life using SF-36 tool showed significantly increase in both physical component score (weighted mean differences of 0.428, p <0.001) and psychological component score (weighted mean differences of 0.277, p <0.001) postoperatively compared with the baseline values. The assessment of QOL using the Thy PRO questionnaire also showed significantly improvement in total QOL score after surgery compared with before that (weighted mean differences of -1.466, p <0.001). We revealed considerably improving both physical and mental aspects of QOL following surgery in Graves’ disease.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87783549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-22DOI: 10.26655/JMCHEMSCI.2021.5.1
Wenqin Huang, Yuhui Yang
The concepts and practices of health in Confucius philosophy may provide patients with a possible way to dealing with life. This study aimed at exploring Confucius's understanding of health, good life, and well-being related to harmony. Documentation analysis was used to examine the meaning of health-related to harmony in Confucius philosophy. A qualitative approach was employed to identify concepts and practices regarding harmony. This research revealed Confucius's understanding of health, good life, and well-being based on harmony, which may provide a life philosophy to patients, a new perspective on living with illness, and offers a possible way for patients to deal with challenges.
{"title":"Harmony (和): Concepts and Practice of Health in Confucius Philosophy Provided for People with Diseases","authors":"Wenqin Huang, Yuhui Yang","doi":"10.26655/JMCHEMSCI.2021.5.1","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.5.1","url":null,"abstract":"The concepts and practices of health in Confucius philosophy may provide patients with a possible way to dealing with life. This study aimed at exploring Confucius's understanding of health, good life, and well-being related to harmony. Documentation analysis was used to examine the meaning of health-related to harmony in Confucius philosophy. A qualitative approach was employed to identify concepts and practices regarding harmony. This research revealed Confucius's understanding of health, good life, and well-being based on harmony, which may provide a life philosophy to patients, a new perspective on living with illness, and offers a possible way for patients to deal with challenges.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86857353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.26655/JMCHEMSCI.2021.4.11
Abramov Alexey Yurievich, Sharapova Olga Viktorovna, R.S.Goloshchapov-Aksenov Roman Sergeevich, Kicha Dmitry Ivanovich, Rukodayny Oleg Vladimirovich, Nazarov Aleksandr Mikhaylovich, Gerasimova Liudmila Ivanovna, Fomina Roza Vladimirovna
Electronic medical records are a source of large amounts of information about human health. This study aimed to investigate the role of big data electronic medical records of patients with cardiovascular diseases to improve the clinical management of cardiovascular care processes. The study was carried out in 2017-2020. The subjects of the study were patients with cardiovascular diseases (n=2525) and cardiovascular surgeons of the vascular surgery department (n=6), forming big data with the help of digitalization and data analysis information system Interin ProMIS. Efficiency was assessed based on the results of analytical studies of the department's economic indicators, risks of end-cardiovascular points (myocardial infarction, stroke, death, bleeding), repeated surgeries, patients' persistence to optimal drug therapy, and implementation of doctor's recommendations. The study estimated the degree of cognitive and physical load on medical personnel in connection with the use of electronic medical turnover in terms of working hours, and economic efficiency of inpatient treatment. The observation time was 24 months. Analytical, statistical methods of research were applied. Revenues of the department increased from 64180 to 113497 thousand rubles. The incidence of endpoint cardiovascular events made 0.5% during two years of follow-up. The number of cardiovascular patients supervised by surgeons decreased to 4 patients per day against the background of electronic document management, which reduced the degree of cognitive and physical load. Big data analytics of electronic medical records contributes to the development of effective strategies for clinical management of the processes aimed at improving the health of cardiovascular patients.
{"title":"Clinical Management of Cardiovascular Care on the Basis of Big Data: Electronic Medical Records","authors":"Abramov Alexey Yurievich, Sharapova Olga Viktorovna, R.S.Goloshchapov-Aksenov Roman Sergeevich, Kicha Dmitry Ivanovich, Rukodayny Oleg Vladimirovich, Nazarov Aleksandr Mikhaylovich, Gerasimova Liudmila Ivanovna, Fomina Roza Vladimirovna","doi":"10.26655/JMCHEMSCI.2021.4.11","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.11","url":null,"abstract":"Electronic medical records are a source of large amounts of information about human health. This study aimed to investigate the role of big data electronic medical records of patients with cardiovascular diseases to improve the clinical management of cardiovascular care processes. The study was carried out in 2017-2020. The subjects of the study were patients with cardiovascular diseases (n=2525) and cardiovascular surgeons of the vascular surgery department (n=6), forming big data with the help of digitalization and data analysis information system Interin ProMIS. Efficiency was assessed based on the results of analytical studies of the department's economic indicators, risks of end-cardiovascular points (myocardial infarction, stroke, death, bleeding), repeated surgeries, patients' persistence to optimal drug therapy, and implementation of doctor's recommendations. The study estimated the degree of cognitive and physical load on medical personnel in connection with the use of electronic medical turnover in terms of working hours, and economic efficiency of inpatient treatment. The observation time was 24 months. Analytical, statistical methods of research were applied. Revenues of the department increased from 64180 to 113497 thousand rubles. The incidence of endpoint cardiovascular events made 0.5% during two years of follow-up. The number of cardiovascular patients supervised by surgeons decreased to 4 patients per day against the background of electronic document management, which reduced the degree of cognitive and physical load. Big data analytics of electronic medical records contributes to the development of effective strategies for clinical management of the processes aimed at improving the health of cardiovascular patients.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74635312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.26655/JMCHEMSCI.2021.4.12
Tolstova A.S., Labzina M.V., Labzina L. Ya, Tokareva N.G., Nechaikin A.S.
Women, particularly healthy women, need medical attention in order to carry out their sexual and reproductive functions safely and effectively. There has been a massive expansion of health technology and health systems in the second half of this century to provide women with many aspects of reproductive health care. There are numerous problems related to the impairment of women's reproductive health during the infancy or teenage years. The great importance among gynecological pathologies assigns to vulvovaginitis. It is the most frequent reason for visits to children's gynecologists. The development of the disease is promoted by anatomo-physiological features of a girl`s genital tracts before puberty, bacterial and viral agents, the neglect of personal hygiene rules, helminthic invasion, allergic disorders, endocrine pathology. During the course of medical-preventive and rehabilitation actions for vulvovaginitis in girls, a special approach requires psychological support, which is built on the root causes of their problems, and various health-related aspects, since in no other field is the relationship between psychology and physiology as close as in the field of sexuality and the reproductive health. Thus, the studying of clinical-psychological features of vulvovaginitis remains relevant since it helps to prevent critical consequences during the formation of the reproductive system.
{"title":"Vulvovaginitis in Girls: Clinico-Psychological Aspect","authors":"Tolstova A.S., Labzina M.V., Labzina L. Ya, Tokareva N.G., Nechaikin A.S.","doi":"10.26655/JMCHEMSCI.2021.4.12","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.12","url":null,"abstract":"Women, particularly healthy women, need medical attention in order to carry out their sexual and reproductive functions safely and effectively. There has been a massive expansion of health technology and health systems in the second half of this century to provide women with many aspects of reproductive health care. There are numerous problems related to the impairment of women's reproductive health during the infancy or teenage years. The great importance among gynecological pathologies assigns to vulvovaginitis. It is the most frequent reason for visits to children's gynecologists. The development of the disease is promoted by anatomo-physiological features of a girl`s genital tracts before puberty, bacterial and viral agents, the neglect of personal hygiene rules, helminthic invasion, allergic disorders, endocrine pathology. During the course of medical-preventive and rehabilitation actions for vulvovaginitis in girls, a special approach requires psychological support, which is built on the root causes of their problems, and various health-related aspects, since in no other field is the relationship between psychology and physiology as close as in the field of sexuality and the reproductive health. Thus, the studying of clinical-psychological features of vulvovaginitis remains relevant since it helps to prevent critical consequences during the formation of the reproductive system.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80863797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.26655/JMCHEMSCI.2021.4.1
Santri Raminda, I. Astuti, Umi Budi Rahayu
Ischemic stroke becomes the reason why some neural networks as well as cortico-subcortical excitability change either in the evidently spared contralateral hemisphere of the upper extremity or in the affected area. The processes are modulated through recent non-invasive brain stimulation techniques. In particular, a rehabilitation program and non-invasive instrument called transcranial magnetic stimulation (TMS) has already been implemented to examine the changes in brain plasticity caused by stroke and used as a therapeutic modality to securely increase the function of motor and activities of daily living (ADL). This study investigated the effect of low-frequency TMS with rehabilitation programs in post-ischemic stroke patients to improve the upper extremity's motor function. Randomized controlled trial was conducted in this study by dividing 11 patients into two groups which fulfilled the present inclusion criteria. Wolf Motor Function Test (WMFT) and Upper Extremity Fugl Meyer Assessment (UEFMA) were used to ADL of day 7 and to measure the levels of motor function, respectively. The study results showed a considerable difference in TMS with the rehabilitation program which was achieved on day seven on both groups. The total score of UEFMA and WMFT considerably increased from the condition before intervention (UEFMA intervention-control: 19.83-6.00; WMFT intervention-control: 20.67–4.00, p < 0.001). Therefore, low-frequency TMS with a rehabilitation program is recommended since it shows a considerable increase in the motor function of the upper extremity and ADL among the patients with post-ischemic stroke.
{"title":"Effect of Transcranial Magnetic Stimulation with Rehabilitation Program on Motor Function and ADL in Upper Extremity Ischemic Stroke: A Randomized Controlled Trials","authors":"Santri Raminda, I. Astuti, Umi Budi Rahayu","doi":"10.26655/JMCHEMSCI.2021.4.1","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.1","url":null,"abstract":"Ischemic stroke becomes the reason why some neural networks as well as cortico-subcortical excitability change either in the evidently spared contralateral hemisphere of the upper extremity or in the affected area. The processes are modulated through recent non-invasive brain stimulation techniques. In particular, a rehabilitation program and non-invasive instrument called transcranial magnetic stimulation (TMS) has already been implemented to examine the changes in brain plasticity caused by stroke and used as a therapeutic modality to securely increase the function of motor and activities of daily living (ADL). This study investigated the effect of low-frequency TMS with rehabilitation programs in post-ischemic stroke patients to improve the upper extremity's motor function. Randomized controlled trial was conducted in this study by dividing 11 patients into two groups which fulfilled the present inclusion criteria. Wolf Motor Function Test (WMFT) and Upper Extremity Fugl Meyer Assessment (UEFMA) were used to ADL of day 7 and to measure the levels of motor function, respectively. The study results showed a considerable difference in TMS with the rehabilitation program which was achieved on day seven on both groups. The total score of UEFMA and WMFT considerably increased from the condition before intervention (UEFMA intervention-control: 19.83-6.00; WMFT intervention-control: 20.67–4.00, p < 0.001). Therefore, low-frequency TMS with a rehabilitation program is recommended since it shows a considerable increase in the motor function of the upper extremity and ADL among the patients with post-ischemic stroke.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86698195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.26655/JMCHEMSCI.2021.4.3
Slametiningsih Slametiningsih, Ninik Yunitri, H. Hendra, Radiatan Khlila, A. Kamil
The purpose of this research was to review the feasibility of the Me-Co Care to be applied in the community setting as well as its effect in increasing participant’s knowledge. This study was conducted in Jakarta, Indonesia, from July to November 2019 and used a pre-post-test without a control group design. Ninety-three participants recruited from five community health centres were assigned to use Me-Co Care. A paired t-Test was used to analyse the mean difference of knowledge before and after the intervention, while the feasibility of application was measured based on the percentage the five evaluation domains. The results showed significant improvement of participants’ knowledge after the intervention (mean different 1.67, 95%; CI 0.00-6.00, p-Value 0.000). Patient, caregiver, health volunteer, and mental health nurse found Me-Co Care a satisfied application to be used in community in terms of content, accuracy, format, easiness, and time-saving (ranged 79%-100%). This study revealed Me-Co Care as a potential application in enhancing the quality of mental health services in Jakarta, Indonesia.
{"title":"The Feasibility of Mobile Health Application “Me-Co Care” in Supporting Health Services in the Community","authors":"Slametiningsih Slametiningsih, Ninik Yunitri, H. Hendra, Radiatan Khlila, A. Kamil","doi":"10.26655/JMCHEMSCI.2021.4.3","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.3","url":null,"abstract":"The purpose of this research was to review the feasibility of the Me-Co Care to be applied in the community setting as well as its effect in increasing participant’s knowledge. This study was conducted in Jakarta, Indonesia, from July to November 2019 and used a pre-post-test without a control group design. Ninety-three participants recruited from five community health centres were assigned to use Me-Co Care. A paired t-Test was used to analyse the mean difference of knowledge before and after the intervention, while the feasibility of application was measured based on the percentage the five evaluation domains. The results showed significant improvement of participants’ knowledge after the intervention (mean different 1.67, 95%; CI 0.00-6.00, p-Value 0.000). Patient, caregiver, health volunteer, and mental health nurse found Me-Co Care a satisfied application to be used in community in terms of content, accuracy, format, easiness, and time-saving (ranged 79%-100%). This study revealed Me-Co Care as a potential application in enhancing the quality of mental health services in Jakarta, Indonesia.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81213257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Optimal leg muscle activity is one of the essential factors to maintain body stability. The condition of the pedis arch could affect the musculoskeletal structure and biomechanics of the body. Furthermore, age and sex also affect the formations of the pedis arch. The objective is to determine the relationship between the degree of flat foot and the activation of the lower leg muscles in children aged 12 years old. The study was conducted using the correlational method with a Cross-Sectional approach. The sample of the study included 15 girls aged 12 years old. The independent variable was measured by the wet footprint test with Clarke's angle category method and the dependent variable was measured by sEMG. The results showed that there was no relationship between flat foot and lower leg muscle activation in children aged 12 years old (p>0.05) with p-value of 0.58, 0.462, and 0.642 for the activation of anterior tibial muscle, the medial gastrocnemius muscle, and the lateral gastrocnemius muscle, respectively. There was no relationship between the flat foot and the activation of lower leg muscles in children aged 12 years.
{"title":"Relationship between Flat Foot and Lower Limb Muscle Activation among 12 Years Old Children","authors":"A. Naufal, Tiara Fatmarizka, Umi Budi Rahayu, Durrotun Nafi’ah, Yayu Latifah, Rahmi Windhy Astari","doi":"10.26655/JMCHEMSCI.2021.4.9","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.9","url":null,"abstract":"Optimal leg muscle activity is one of the essential factors to maintain body stability. The condition of the pedis arch could affect the musculoskeletal structure and biomechanics of the body. Furthermore, age and sex also affect the formations of the pedis arch. The objective is to determine the relationship between the degree of flat foot and the activation of the lower leg muscles in children aged 12 years old. The study was conducted using the correlational method with a Cross-Sectional approach. The sample of the study included 15 girls aged 12 years old. The independent variable was measured by the wet footprint test with Clarke's angle category method and the dependent variable was measured by sEMG. The results showed that there was no relationship between flat foot and lower leg muscle activation in children aged 12 years old (p>0.05) with p-value of 0.58, 0.462, and 0.642 for the activation of anterior tibial muscle, the medial gastrocnemius muscle, and the lateral gastrocnemius muscle, respectively. There was no relationship between the flat foot and the activation of lower leg muscles in children aged 12 years.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87925981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.26655/JMCHEMSCI.2021.4.10
V. S. Slyusarenko, M. Korokin, S. Kovalenko, Aleksandr N. Stadnichenko, L. Korokina
This experimental laboratory animals research aimed at the anti-inflammatory activity of a new dipharmacophore derivative dexibuprofen and nebracetam when modeling an acute and chronic inflammatory reaction. The studied dipharmacophore compound based on dexibuprofen and nebracetam is indicated by the dexibuneb laboratory code and has the chemical formula (2S) -N - ((1-benzyl-5-hydroxypyrrolidin-3-yl) methyl) -2- (4-isobutylphenyl) propanamide. Dexibuneb was administered intragastrically at a dose of 80 mg/kg; dexibuprofen and nebracetam were administered intragastrically at a dose of 40 mg/kg. The minimum increase in paw edema was recorded in the group of animals treated with dexibuneb. It amounted to 33.61 ± 7.41 of the initial value, which is statistically significantly (p <0.05) less than the values both in the control group and in the groups treated with dexibuprofen nebracetam monotherapy. The use of dexibuneb reduced the increase in dry weight of the granuloma by 43.09% (p <0.05) relative to the increase in the control group. In this study, when studying the severity of the anti-inflammatory effect on acute and chronic inflammation models, we found a positive pharmacodynamic interaction of molecular fragments of various therapeutic orientations, combined in an innovative dipharmacophore compound with the laboratory name dexibuneb. Inhibition of paw edema after introducing carrageenan into the plantar aponeurosis and the increase in the mass of granulomas implanted in rat armpits was statistically significantly more pronounced in the groups of animals treated with dexibuneb than with dexibuprofen and nebracetam monotherapy.
{"title":"Anti-Inflammatory Activity of a New Dipharmacophore Derivative of Propionic Acid","authors":"V. S. Slyusarenko, M. Korokin, S. Kovalenko, Aleksandr N. Stadnichenko, L. Korokina","doi":"10.26655/JMCHEMSCI.2021.4.10","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.10","url":null,"abstract":"This experimental laboratory animals research aimed at the anti-inflammatory activity of a new dipharmacophore derivative dexibuprofen and nebracetam when modeling an acute and chronic inflammatory reaction. The studied dipharmacophore compound based on dexibuprofen and nebracetam is indicated by the dexibuneb laboratory code and has the chemical formula (2S) -N - ((1-benzyl-5-hydroxypyrrolidin-3-yl) methyl) -2- (4-isobutylphenyl) propanamide. Dexibuneb was administered intragastrically at a dose of 80 mg/kg; dexibuprofen and nebracetam were administered intragastrically at a dose of 40 mg/kg. The minimum increase in paw edema was recorded in the group of animals treated with dexibuneb. It amounted to 33.61 ± 7.41 of the initial value, which is statistically significantly (p <0.05) less than the values both in the control group and in the groups treated with dexibuprofen nebracetam monotherapy. The use of dexibuneb reduced the increase in dry weight of the granuloma by 43.09% (p <0.05) relative to the increase in the control group. In this study, when studying the severity of the anti-inflammatory effect on acute and chronic inflammation models, we found a positive pharmacodynamic interaction of molecular fragments of various therapeutic orientations, combined in an innovative dipharmacophore compound with the laboratory name dexibuneb. Inhibition of paw edema after introducing carrageenan into the plantar aponeurosis and the increase in the mass of granulomas implanted in rat armpits was statistically significantly more pronounced in the groups of animals treated with dexibuneb than with dexibuprofen and nebracetam monotherapy.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89412431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.26655/JMCHEMSCI.2021.4.7
D. Hudiyawati, Khumasyi Ainunnisa, Grahinda Riskamala
Self-care is an essential factor that affects the improvement of the health conditions of patients with heart failure. It is known that several variables affect self-care, including self-efficacy, family support, social support, distress, age, duration of illness. However, there are still few studies that have addressed these variables together. This study aimed to determine the factors that affect self-care among heart failure patients. This research used an analytic observational research design through a cross-sectional approach. The sampling method used an accidental sampling technique and resulted in 73 respondents who were selected based on pre-determined sample criteria. Participants were asked to fill out questionnaires, including self-care, self-efficacy, family support, anxiety, and demography variables. The data analysis included bivariate (Pearson) and multivariate regression analysis to estimate the correlation between self-care and self-efficacy, family support, anxiety, age, and disease length. 73 patients with heart failure in this study had an average self-care score of 31.33, which means that patients can do self-care well. From the five variables carried out in the multivariate analysis, there were only two variables (family support and self-efficacy) that had a significant effect on patient self-care. Family support is the main factor affecting self-care (β= 1,949, p= 0.000), followed by self-efficacy (β= 0.226, p= 0.001), then self-efficacy, where both had a positive correlation. The results indicated that a strategy is needed to improve self-care for heart failure patients, which includes family support and self-efficacy to achieve optimal results.
{"title":"Self-Care and Its Related Factors among Patients with Congestive Heart Failure in Surakarta, Indonesia","authors":"D. Hudiyawati, Khumasyi Ainunnisa, Grahinda Riskamala","doi":"10.26655/JMCHEMSCI.2021.4.7","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2021.4.7","url":null,"abstract":"Self-care is an essential factor that affects the improvement of the health conditions of patients with heart failure. It is known that several variables affect self-care, including self-efficacy, family support, social support, distress, age, duration of illness. However, there are still few studies that have addressed these variables together. This study aimed to determine the factors that affect self-care among heart failure patients. This research used an analytic observational research design through a cross-sectional approach. The sampling method used an accidental sampling technique and resulted in 73 respondents who were selected based on pre-determined sample criteria. Participants were asked to fill out questionnaires, including self-care, self-efficacy, family support, anxiety, and demography variables. The data analysis included bivariate (Pearson) and multivariate regression analysis to estimate the correlation between self-care and self-efficacy, family support, anxiety, age, and disease length. 73 patients with heart failure in this study had an average self-care score of 31.33, which means that patients can do self-care well. From the five variables carried out in the multivariate analysis, there were only two variables (family support and self-efficacy) that had a significant effect on patient self-care. Family support is the main factor affecting self-care (β= 1,949, p= 0.000), followed by self-efficacy (β= 0.226, p= 0.001), then self-efficacy, where both had a positive correlation. The results indicated that a strategy is needed to improve self-care for heart failure patients, which includes family support and self-efficacy to achieve optimal results.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80291118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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