Intravascular adenomyosis was discovered in a cynomolgus macaque, a previously unreported presentation of adenomyosis in non-human primates that points to vascular involvement in adenomyosis etiology. Uterus gross exam was unremarkable, but histologic examination revealed multifocal endometrial tissue intimately associated with large thin-walled myometrial vessels and surrounded by CD31 immunopositive endothelium.
RNA extraction from five HBsAg-positive Cercopithecidae samples, followed by semi-nested PCR of the four overlapping regions of the HBV genome and phylogenetic analyses, yielded a complete HBV genome. This strain from a Cercopithecus preussi sample has close genetic proximity to isolates from Cameroonian great apes, suggesting cross-species transmission of HBV.
Baboons are valuable models for human health research, yet existing hematology, serum chemistry, and growth reference data are limited by small sample sizes, narrow age ranges, and inconsistent reporting.
This study addresses these gaps by analyzing data from 848 captive olive baboons to establish comprehensive reference intervals and growth curves. We examined variations in hematology and serum chemistry across age, sex, rearing history (mother- vs. nursery-reared), and viral status (specific pathogen free vs. conventional).
Significant differences were found in 58.8% (10/17) of hematology and 37% (10/27) of chemistry parameters between SPF and conventional baboons, as well as across age, sex, and rearing categories. Growth curves aligned with previous studies but showed higher weight ranges.
While many differences were statistically significant, not all may be clinically relevant. These findings provide a robust resource for veterinary care and biomedical research involving baboons.
Spontaneous meningiomas are rarely reported in nonhuman primates, and among the documented cases, only a few are thoroughly characterized. This report describes a case of atypical meningioma in a pregnant rhesus macaque (Macaca mulatta) that exhibits pathobiological features that mirror humans.
A managed-care female common marmoset developed a rare C-cell carcinoma in the right thyroid lobe, characterized by capsular and intrathyroidal invasion. Neoplastic plasmacytoid cells arranged in sheets exhibited a morphological and immunophenotypic profile (calcitonin+, chromogranin A+, CK7+, INSM1+, TTF-1) that closely resembles human thyroid C-cell tumors.
Tongue squamous cell carcinoma (TSCC) is a typical and prevalent neoplasm in non-human primates (NHPs). However, comprehensive pathological and immunohistochemical analyses of TSCC in rhesus monkeys have been infrequently documented.
Three rhesus monkeys with TSCC were sourced from the same breeding facility. Laboratory tests, gross observation of the lesion tissue, and human papillomavirus content testing using real-time fluorescence PCR method of the animals were carried out. The animals underwent necropsy for examination of tissues and organs, followed by histopathological and immunohistochemical analysis.
The clinical manifestations observed across all animals included salivation, swelling, sclerosis, and ulceration of the tongue. All three rhesus monkeys were euthanized due to deteriorating health conditions. No abnormalities were noted in other organs during post-mortem examination except for their tongues. Histopathological examination revealed an invasive tumor characterized by nests of polygonal cells within the stroma, accompanied by significant desmoplastic reactions and occasional cancerous beads. All cases demonstrated positive immunolabeling for p63, CK5/6, p40, CK19, CK7, and CK20 via immunohistochemistry (IHC) analysis.
The clinical manifestations and pathological examination of the three cases were consistent with the characteristics of highly differentiated squamous cell carcinoma. Additionally, immunohistochemical analysis revealed positive expression of p63, CK5/6, p40, CK19, CK7, and CK20. In three cases, the results of human papillomavirus were negative. This study provides an important reference for the diagnosis of TSCC in rhesus monkeys.
Leptospirosis is an emerging zoonotic disease caused by pathogenic Leptospira spp., affecting a wide range of domestic and wild mammals including nonhuman primates (NHPs). Despite rising incidence rates in both NHPs and humans, there is a lack of comprehensive resources addressing leptospirosis in NHPs from a veterinary perspective in a One Health approach. The close phylogenetic relationship between NHPs, humans and the similarities in disease progression may reveal valuable insights into the pathophysiology, diagnosis, treatment, control measures, and surveillance of leptospirosis. This review synthesizes existing literature on leptospirosis in NHPs, focusing on diagnosis, control measures, and surveillance. It offers insights into the prevalence among NHPs, environmental and civilization factors affecting Leptospira spp. dynamics, and recommendations for the diagnosis, management, and monitoring of leptospirosis. The findings highlight the need for coordinated research efforts and integrated surveillance systems to reduce leptospirosis risk in NHPs.
Canine distemper virus (CDV) has markedly expanded its known host range over the recent past decades. CDV infection has been reported in old-world primates of the genus Macaca, with reports between the 1980s and 2008 in Japan and China. Over the past months, independent research groups in Brazil reported an individual case and two outbreaks of CDV infection affecting free-ranging marmosets (Callithrix spp.) from different regions of the country. Clinical manifestations, pathological changes and viral tropism in neotropical primates are discussed. Furthermore, potential consequences on conservation of endangered species of neotropical primates and potential host adaptation to primates that may eventually favor human infections are also discussed. It is still unclear whether these independent reports of CDV infection in neotropical primates in such a short period of time may be due to an epizootic situation or to an increased efficiency of the surveillance system in place in Brazil.
The Peruvian Amazon is an endemic region for integumentary leishmaniasis, characterized by multiple vectors species, diverse wildlife reservoirs, and human activities that influence disease transmission. Non-human primates (NHPs) have been implicated as potential reservoirs for Leishmania spp. and Trypanosoma cruzi in neighboring Brazil, but their role in Cacajao spp. remains unknown. This study aimed to detect Leishmania spp. and T. cruzi DNA in semi-captive Peruvian bald uakaris (Cacajao calvus) housed at the Pilpintuwasi Rescue Center, Iquitos, Peru.
Seven individuals were chemically restrained, and blood samples were collected. DNA was extracted and analyzed using PCR with primers targeting the heat-shock protein 70 (HSP70) gene for Leishmania spp. and kinetoplast DNA (kDNA) for T. cruzi. Mitochondrial DNA sequencing using a novel CacajaoID primer set confirmed species and subspecies identity. Analytical sensitivity assays were also performed to ensure assay the reliability and detection limit of both PCR protocols.
All specimens tested negative for both pathogens. Sequencing of the CacajaoID fragment confirmed five individuals as C. c. ucayalii and two as C. c. novaesi.
Although no parasite DNA was detected, these findings provide baseline molecular and epidemiological Data for bald uakaris and highlight the importance of continued surveillance in semi-captive and wild populations. The results support one health approaches by linking wildlife monitoring with conservation and zoonotic risk assessments in the Amazon region.
Cardiovascular and hemodynamic status can both be modified by cardiovascular risk factors which themselves depend on housing conditions.
Cynomolgus macaques maintained in large enclosures allowing them to perform physical exercise and social interactions were evaluated for cardiovascular and metabolic parameters in three age groups (2–4, 5–10, and 10–15).
Liver and kidney functions were stable but an important variability of the blood neutrophil count was noticed. In males, an increase in alkaline phosphatase was noted in young animals while lipid parameters were altered over time with increases in triglycerides and cholesterol. Some diastolic disorders were observed in older males. No electrocardiographic abnormalities were observed. Finally, we observed usual physiological changes due to gestation.
Housing conditions closer to those in the wild provide an improved health status over non-human primates that are housed in more crowded housing conditions.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：