Thyago Habner de Souza Pereira, Frederico Ozanan Barros Monteiro, Francisco Antônio Félix Xavier Júnior, Isadora Oliveira de Carvalho, Janaina Serra Azul Monteiro Evangelista, Ana Kelen Felipe Lima, Pedro Mayor
Introduction
This study microscopically characterizes collagen changes and their relationship with endometrial architecture in two Neotropical primates.
Methods
Uterine fragments from six Lagothrix l. poeppigii and six Cacajao calvus in different reproductive phases were histologically processed using Picrosirius Red staining.
Results
In the functional layer, collagen was highest in the early proliferative phase (5.19% ± 2.53%; p < 0.001), whereas the basal layer had the lowest percentage (5.85% ± 4.69%; p < 0.01). Type I collagen predominated, while type III was less expressed. Type I collagen varied significantly between proliferative phases (p < 0.001). The basal layer exhibited more fibers in the secretory phase (14.03% ± 8.50%; p < 0.001). Type III collagen peaked in the functional layer (0.41% ± 0.17%; p < 0.001) and basal layer (0.69% ± 0.46%; p < 0.05).
Conclusion
Picrosirius Red staining with polarized light effectively highlights collagen organization, aiding reproductive phase characterization in Neotropical primates.
{"title":"Endometrial Collagen in Woolly Monkey (Lagothrix l. poeppiggi) and the Uakari (Cacajao calvus)","authors":"Thyago Habner de Souza Pereira, Frederico Ozanan Barros Monteiro, Francisco Antônio Félix Xavier Júnior, Isadora Oliveira de Carvalho, Janaina Serra Azul Monteiro Evangelista, Ana Kelen Felipe Lima, Pedro Mayor","doi":"10.1111/jmp.70055","DOIUrl":"10.1111/jmp.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This study microscopically characterizes collagen changes and their relationship with endometrial architecture in two Neotropical primates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Uterine fragments from six <i>Lagothrix l. poeppigii</i> and six <i>Cacajao calvus</i> in different reproductive phases were histologically processed using Picrosirius Red staining.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the functional layer, collagen was highest in the early proliferative phase (5.19% ± 2.53%; <i>p</i> < 0.001), whereas the basal layer had the lowest percentage (5.85% ± 4.69%; <i>p</i> < 0.01). Type I collagen predominated, while type III was less expressed. Type I collagen varied significantly between proliferative phases (<i>p</i> < 0.001). The basal layer exhibited more fibers in the secretory phase (14.03% ± 8.50%; <i>p</i> < 0.001). Type III collagen peaked in the functional layer (0.41% ± 0.17%; <i>p</i> < 0.001) and basal layer (0.69% ± 0.46%; <i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Picrosirius Red staining with polarized light effectively highlights collagen organization, aiding reproductive phase characterization in Neotropical primates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"55 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hwanhoon Park, Do Na Lee, Seongchan Yeon, Won-gyun Son
A male rhesus macaque underwent inguinal hernia repair under general anesthesia, with epidural anesthesia administered at the fourth lumbar vertebral level using a nerve stimulator-guided technique. This method provided effective analgesia and stable hemodynamics, supporting its potential as an objective alternative to landmark-based approaches in nonhuman primates.
{"title":"Nerve Stimulator-Guided Epidural Anesthesia in a Rhesus Macaque (Macaca mulatta)","authors":"Hwanhoon Park, Do Na Lee, Seongchan Yeon, Won-gyun Son","doi":"10.1111/jmp.70057","DOIUrl":"10.1111/jmp.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>A male rhesus macaque underwent inguinal hernia repair under general anesthesia, with epidural anesthesia administered at the fourth lumbar vertebral level using a nerve stimulator-guided technique. This method provided effective analgesia and stable hemodynamics, supporting its potential as an objective alternative to landmark-based approaches in nonhuman primates.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"55 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ratih Rinendyaputri, Frans Dany, Sela Septima Mariya, Novaria Sari Dewi Panjaitan, Uly Alfi Nikmah, Hieronimus Adiyoga Nareswara, Alvian Dumingan, Sonny Sonny, Rio Handi Sanjaya, Amarila Malik, Rahardianty Hanum Tazkia, Yulia Irnidiyanti, Hasta Handayani Idrus, Wireni Ayuningtyas, Rachmawati Noverina, Fathul Huda, Ahmad Faried
UC-MSCs appear to be a viable option for stem cell-based treatment. Cynomolgus monkeys, with their psychological and genetic parallels to humans, are essential models for medical study and development. Hypoxia is a basic characteristic of angiogenesis, glucose metabolism, and cell proliferation and survival in both healthy and pathological individuals. This study aimed to develop and characterize UC-MSCs requirements derived from the cynomolgus monkey. We have successfully developed UC-MSCs derived from Mf under hypoxic conditions. Mf UC-MSCs was cultured from the WJ area. Our Mf UC-MSCs have developed into adipocytes, osteocytes, and chondrocytes. The protein of the biomarker MSC was expressed in our hypoxic precondition Mf UC-MSCs and the mRNA expression levels of ERK1/2, AKT1, and HIF-1 alpha increased in the hypoxic condition compared to the normoxic and control groups. The JNK and NFκB genes were decreased in the hypoxic group. Interestingly, our hypoxic Mf UC-MSCs suppressed IL-6 expression. These findings show that preconditioned Mf UC-MSCs produce anti-inflammatory properties, making them potential candidates for regenerative medicine. Their response to hypoxia is crucial for developing targeted therapies to enhance regenerative capabilities in conditions such as ischemic injury and neurodegeneration.
{"title":"Characterization of Hypoxia-Preconditioned Umbilical Cord Mesenchymal Stem Cells Derived From Macaca fascicularis","authors":"Ratih Rinendyaputri, Frans Dany, Sela Septima Mariya, Novaria Sari Dewi Panjaitan, Uly Alfi Nikmah, Hieronimus Adiyoga Nareswara, Alvian Dumingan, Sonny Sonny, Rio Handi Sanjaya, Amarila Malik, Rahardianty Hanum Tazkia, Yulia Irnidiyanti, Hasta Handayani Idrus, Wireni Ayuningtyas, Rachmawati Noverina, Fathul Huda, Ahmad Faried","doi":"10.1111/jmp.70056","DOIUrl":"10.1111/jmp.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>UC-MSCs appear to be a viable option for stem cell-based treatment. Cynomolgus monkeys, with their psychological and genetic parallels to humans, are essential models for medical study and development. Hypoxia is a basic characteristic of angiogenesis, glucose metabolism, and cell proliferation and survival in both healthy and pathological individuals. This study aimed to develop and characterize UC-MSCs requirements derived from the cynomolgus monkey. We have successfully developed UC-MSCs derived from <i>Mf</i> under hypoxic conditions. <i>Mf</i> UC-MSCs was cultured from the WJ area. Our <i>Mf</i> UC-MSCs have developed into adipocytes, osteocytes, and chondrocytes. The protein of the biomarker MSC was expressed in our hypoxic precondition <i>Mf</i> UC-MSCs and the mRNA expression levels of <i>ERK1/2</i>, <i>AKT1</i>, and <i>HIF-1</i> alpha increased in the hypoxic condition compared to the normoxic and control groups. The <i>JNK</i> and <i>NFκB</i> genes were decreased in the hypoxic group. Interestingly, our hypoxic Mf UC-MSCs suppressed IL-6 expression. These findings show that preconditioned <i>Mf</i> UC-MSCs produce anti-inflammatory properties, making them potential candidates for regenerative medicine. Their response to hypoxia is crucial for developing targeted therapies to enhance regenerative capabilities in conditions such as ischemic injury and neurodegeneration.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"55 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah M. Ruetten, Abolfazl S. Abdolmaleki, Anthony Atala, J. Koudy Williams, J. Mark Cline
Intravascular adenomyosis was discovered in a cynomolgus macaque, a previously unreported presentation of adenomyosis in non-human primates that points to vascular involvement in adenomyosis etiology. Uterus gross exam was unremarkable, but histologic examination revealed multifocal endometrial tissue intimately associated with large thin-walled myometrial vessels and surrounded by CD31 immunopositive endothelium.
{"title":"Intravascular Adenomyosis in a Cynomolgus Macaque (Macaca Fascicularis)","authors":"Hannah M. Ruetten, Abolfazl S. Abdolmaleki, Anthony Atala, J. Koudy Williams, J. Mark Cline","doi":"10.1111/jmp.70058","DOIUrl":"https://doi.org/10.1111/jmp.70058","url":null,"abstract":"<p>Intravascular adenomyosis was discovered in a cynomolgus macaque, a previously unreported presentation of adenomyosis in non-human primates that points to vascular involvement in adenomyosis etiology. Uterus gross exam was unremarkable, but histologic examination revealed multifocal endometrial tissue intimately associated with large thin-walled myometrial vessels and surrounded by CD31 immunopositive endothelium.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"55 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Foupouapouognigni Yacouba, Modiyinji Abdou Fatawou, Njouom Richard
RNA extraction from five HBsAg-positive Cercopithecidae samples, followed by semi-nested PCR of the four overlapping regions of the HBV genome and phylogenetic analyses, yielded a complete HBV genome. This strain from a Cercopithecus preussi sample has close genetic proximity to isolates from Cameroonian great apes, suggesting cross-species transmission of HBV.
{"title":"A Retrospective Study Revealed Potential Cross-Transmission of Hepatitis B Virus Between Great Apes and Small Monkeys in Cameroon","authors":"Foupouapouognigni Yacouba, Modiyinji Abdou Fatawou, Njouom Richard","doi":"10.1111/jmp.70053","DOIUrl":"10.1111/jmp.70053","url":null,"abstract":"<div>\u0000 \u0000 <p>RNA extraction from five HBsAg-positive <i>Cercopithecidae</i> samples, followed by semi-nested PCR of the four overlapping regions of the HBV genome and phylogenetic analyses, yielded a complete HBV genome. This strain from a <i>Cercopithecus preussi</i> sample has close genetic proximity to isolates from Cameroonian great apes, suggesting cross-species transmission of HBV.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah J. Neal, Shannon Whitney, Elizabeth Magden, Joe H. Simmons
Background
Baboons are valuable models for human health research, yet existing hematology, serum chemistry, and growth reference data are limited by small sample sizes, narrow age ranges, and inconsistent reporting.
Methods
This study addresses these gaps by analyzing data from 848 captive olive baboons to establish comprehensive reference intervals and growth curves. We examined variations in hematology and serum chemistry across age, sex, rearing history (mother- vs. nursery-reared), and viral status (specific pathogen free vs. conventional).
Results
Significant differences were found in 58.8% (10/17) of hematology and 37% (10/27) of chemistry parameters between SPF and conventional baboons, as well as across age, sex, and rearing categories. Growth curves aligned with previous studies but showed higher weight ranges.
Conclusions
While many differences were statistically significant, not all may be clinically relevant. These findings provide a robust resource for veterinary care and biomedical research involving baboons.
{"title":"Hematological Parameters and Growth Curves for Captive Olive Baboons (Papio anubis): Effects of Viral Status, Sex, Age, and Rearing Status","authors":"Sarah J. Neal, Shannon Whitney, Elizabeth Magden, Joe H. Simmons","doi":"10.1111/jmp.70050","DOIUrl":"10.1111/jmp.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Baboons are valuable models for human health research, yet existing hematology, serum chemistry, and growth reference data are limited by small sample sizes, narrow age ranges, and inconsistent reporting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study addresses these gaps by analyzing data from 848 captive olive baboons to establish comprehensive reference intervals and growth curves. We examined variations in hematology and serum chemistry across age, sex, rearing history (mother- vs. nursery-reared), and viral status (specific pathogen free vs. conventional).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences were found in 58.8% (10/17) of hematology and 37% (10/27) of chemistry parameters between SPF and conventional baboons, as well as across age, sex, and rearing categories. Growth curves aligned with previous studies but showed higher weight ranges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While many differences were statistically significant, not all may be clinically relevant. These findings provide a robust resource for veterinary care and biomedical research involving baboons.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eddie Xu, Avelina Rodgers, Katherine Johnson, Robert V. Blair
Spontaneous meningiomas are rarely reported in nonhuman primates, and among the documented cases, only a few are thoroughly characterized. This report describes a case of atypical meningioma in a pregnant rhesus macaque (Macaca mulatta) that exhibits pathobiological features that mirror humans.
{"title":"Spontaneous Atypical Meningioma in a Pregnant Rhesus Macaque (Macaca mulatta)","authors":"Eddie Xu, Avelina Rodgers, Katherine Johnson, Robert V. Blair","doi":"10.1111/jmp.70049","DOIUrl":"10.1111/jmp.70049","url":null,"abstract":"<p>Spontaneous meningiomas are rarely reported in nonhuman primates, and among the documented cases, only a few are thoroughly characterized. This report describes a case of atypical meningioma in a pregnant rhesus macaque (<i>Macaca mulatta</i>) that exhibits pathobiological features that mirror humans.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel Luana de Macêdo, Nicole Lynn Gottdenker, Lilian J. Oliveira, Davi Emanuel Ribeiro de Sousa, Yasmin Nunes Godoy da Fonseca, Liz de Albuquerque Cerqueira, Betânia Pereira Borges, Márcio Botelho de Castro
A managed-care female common marmoset developed a rare C-cell carcinoma in the right thyroid lobe, characterized by capsular and intrathyroidal invasion. Neoplastic plasmacytoid cells arranged in sheets exhibited a morphological and immunophenotypic profile (calcitonin+, chromogranin A+, CK7+, INSM1+, TTF-1) that closely resembles human thyroid C-cell tumors.
{"title":"C-Cell Carcinoma in a Common Marmoset (Callithrix jacchus) With a Brief Review of Thyroid Neoplasms in Neotropical Primates","authors":"Isabel Luana de Macêdo, Nicole Lynn Gottdenker, Lilian J. Oliveira, Davi Emanuel Ribeiro de Sousa, Yasmin Nunes Godoy da Fonseca, Liz de Albuquerque Cerqueira, Betânia Pereira Borges, Márcio Botelho de Castro","doi":"10.1111/jmp.70051","DOIUrl":"10.1111/jmp.70051","url":null,"abstract":"<p>A managed-care female common marmoset developed a rare C-cell carcinoma in the right thyroid lobe, characterized by capsular and intrathyroidal invasion. Neoplastic plasmacytoid cells arranged in sheets exhibited a morphological and immunophenotypic profile (calcitonin+, chromogranin A+, CK7+, INSM1+, TTF-1) that closely resembles human thyroid C-cell tumors.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12665875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tongue squamous cell carcinoma (TSCC) is a typical and prevalent neoplasm in non-human primates (NHPs). However, comprehensive pathological and immunohistochemical analyses of TSCC in rhesus monkeys have been infrequently documented.
Methods
Three rhesus monkeys with TSCC were sourced from the same breeding facility. Laboratory tests, gross observation of the lesion tissue, and human papillomavirus content testing using real-time fluorescence PCR method of the animals were carried out. The animals underwent necropsy for examination of tissues and organs, followed by histopathological and immunohistochemical analysis.
Results
The clinical manifestations observed across all animals included salivation, swelling, sclerosis, and ulceration of the tongue. All three rhesus monkeys were euthanized due to deteriorating health conditions. No abnormalities were noted in other organs during post-mortem examination except for their tongues. Histopathological examination revealed an invasive tumor characterized by nests of polygonal cells within the stroma, accompanied by significant desmoplastic reactions and occasional cancerous beads. All cases demonstrated positive immunolabeling for p63, CK5/6, p40, CK19, CK7, and CK20 via immunohistochemistry (IHC) analysis.
Conclusions
The clinical manifestations and pathological examination of the three cases were consistent with the characteristics of highly differentiated squamous cell carcinoma. Additionally, immunohistochemical analysis revealed positive expression of p63, CK5/6, p40, CK19, CK7, and CK20. In three cases, the results of human papillomavirus were negative. This study provides an important reference for the diagnosis of TSCC in rhesus monkeys.
{"title":"Squamous Cell Carcinoma of the Tongue in Captive Rhesus Monkeys (Macaca mulatta)","authors":"Heling Li, Zhengbo Wang, Long Zhang, Hong Wang","doi":"10.1111/jmp.70045","DOIUrl":"10.1111/jmp.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tongue squamous cell carcinoma (TSCC) is a typical and prevalent neoplasm in non-human primates (NHPs). However, comprehensive pathological and immunohistochemical analyses of TSCC in rhesus monkeys have been infrequently documented.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Three rhesus monkeys with TSCC were sourced from the same breeding facility. Laboratory tests, gross observation of the lesion tissue, and human papillomavirus content testing using real-time fluorescence PCR method of the animals were carried out. The animals underwent necropsy for examination of tissues and organs, followed by histopathological and immunohistochemical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The clinical manifestations observed across all animals included salivation, swelling, sclerosis, and ulceration of the tongue. All three rhesus monkeys were euthanized due to deteriorating health conditions. No abnormalities were noted in other organs during post-mortem examination except for their tongues. Histopathological examination revealed an invasive tumor characterized by nests of polygonal cells within the stroma, accompanied by significant desmoplastic reactions and occasional cancerous beads. All cases demonstrated positive immunolabeling for p63, CK5/6, p40, CK19, CK7, and CK20 via immunohistochemistry (IHC) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The clinical manifestations and pathological examination of the three cases were consistent with the characteristics of highly differentiated squamous cell carcinoma. Additionally, immunohistochemical analysis revealed positive expression of p63, CK5/6, p40, CK19, CK7, and CK20. In three cases, the results of human papillomavirus were negative. This study provides an important reference for the diagnosis of TSCC in rhesus monkeys.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annemiek Maaskant, Margot Morel, Sherrie Jean, Bon-sang Koo, Siavash Noor, Luiz Cesar Cavalcanti Pereira da Silva, John Chipangura, Francis Vercammen, Remco A. Nederlof, Jaco Bakker
Leptospirosis is an emerging zoonotic disease caused by pathogenic Leptospira spp., affecting a wide range of domestic and wild mammals including nonhuman primates (NHPs). Despite rising incidence rates in both NHPs and humans, there is a lack of comprehensive resources addressing leptospirosis in NHPs from a veterinary perspective in a One Health approach. The close phylogenetic relationship between NHPs, humans and the similarities in disease progression may reveal valuable insights into the pathophysiology, diagnosis, treatment, control measures, and surveillance of leptospirosis. This review synthesizes existing literature on leptospirosis in NHPs, focusing on diagnosis, control measures, and surveillance. It offers insights into the prevalence among NHPs, environmental and civilization factors affecting Leptospira spp. dynamics, and recommendations for the diagnosis, management, and monitoring of leptospirosis. The findings highlight the need for coordinated research efforts and integrated surveillance systems to reduce leptospirosis risk in NHPs.
{"title":"A Guidance for Diagnosis, Control Measures, and Surveillance of Leptospirosis in Non-Human Primates From a Veterinary Perspective in a One-Health Approach","authors":"Annemiek Maaskant, Margot Morel, Sherrie Jean, Bon-sang Koo, Siavash Noor, Luiz Cesar Cavalcanti Pereira da Silva, John Chipangura, Francis Vercammen, Remco A. Nederlof, Jaco Bakker","doi":"10.1111/jmp.70047","DOIUrl":"10.1111/jmp.70047","url":null,"abstract":"<p>Leptospirosis is an emerging zoonotic disease caused by pathogenic <i>Leptospira</i> spp., affecting a wide range of domestic and wild mammals including nonhuman primates (NHPs). Despite rising incidence rates in both NHPs and humans, there is a lack of comprehensive resources addressing leptospirosis in NHPs from a veterinary perspective in a One Health approach. The close phylogenetic relationship between NHPs, humans and the similarities in disease progression may reveal valuable insights into the pathophysiology, diagnosis, treatment, control measures, and surveillance of leptospirosis. This review synthesizes existing literature on leptospirosis in NHPs, focusing on diagnosis, control measures, and surveillance. It offers insights into the prevalence among NHPs, environmental and civilization factors affecting <i>Leptospira</i> spp. dynamics, and recommendations for the diagnosis, management, and monitoring of leptospirosis. The findings highlight the need for coordinated research efforts and integrated surveillance systems to reduce leptospirosis risk in NHPs.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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