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Pain outcome of non-instrumented lumbar decompressive surgery for degenerative lumbar spine disease using patient-reported pain outcome instruments 使用患者报告的疼痛结果器械治疗退行性腰椎疾病的非器械腰椎减压手术的疼痛结果
Q3 Medicine Pub Date : 2023-11-02 DOI: 10.25259/jnrp_80_2022
Moses Osaodion Inojie, Chika Anele Ndubuisi, Okwuoma Okwunodulu, Okiemute Vanita Inojie, Ned Micheal Ndafia, Samuel Chwukwunoyerem Ohaegbulam
Objectives: A clinical disorder known as degenerative lumbar spine disease (DLSD) is characterized by persistent low back pain (LBP) coupled with radiculopathy and other signs of neurologic impairment. Using patient-reported pain outcome assessment tools, this study evaluated the pain outcome of non-instrumented lumbar decompressive surgery for DLSD. Materials and Methods: A prospective longitudinal research was conducted. Using the metric visual analog scale (VAS) score and the Oswestry disability index (ODI), consenting patients who underwent non-instrumented lumbar decompressive surgery for symptomatic DLSD were evaluated for radicular pain and LBP. The evaluation was conducted both immediately before surgery and 6 months after surgery. Data generated by comparing the pre-operative and post-operative VAS and ODI scores were then analyzed using descriptive and inferential statistics. Results: Sixty-seven patients in total completed the study. Thirty-six (54%) males and 31 (46%) females, with a mean age and body mass index of 55.28 years and 29.5 k/m 2 , respectively. At 6 months postoperatively, there was significant pain reduction from the pre-operative baseline VAS for LBP (67.12–32.74) with P < 0.001, VAS for radicular pain (75.39–32.75) with P < 0.001, and ODI (65.30–27.66) with P < 0.001. There was a greater decrease in radicular pain than in LBP following lumbar decompressive only surgery ( P = 0.03). Conclusion: Patients with symptomatic DLSD and high pre-operative back pain scores without considerable listhesis should anticipate a significant reduction in radicular and back pain intensity, as well as pain-related functional disability, 6 months after non-instrumented lumbar decompressive surgery.
目的:一种被称为退行性腰椎疾病(DLSD)的临床疾病,其特征是持续的腰痛(LBP),并伴有神经根病和其他神经系统损伤的迹象。使用患者报告的疼痛结果评估工具,本研究评估了无器械腰椎减压手术治疗DLSD的疼痛结果。材料与方法:前瞻性纵向研究。采用视觉模拟量表(VAS)评分和Oswestry残疾指数(ODI),对接受无器械腰椎减压手术治疗症状性DLSD的患者进行神经根痛和腰痛评估。术前和术后6个月均进行评估。通过比较术前和术后VAS和ODI评分产生的数据,然后使用描述性和推断性统计进行分析。结果:共67例患者完成了研究。男性36例(54%),女性31例(46%),平均年龄55.28岁,体重指数29.5 k/ m2。术后6个月,腰痛VAS基线评分(67.12-32.74)较术前显著减轻,P <0.001,神经根痛VAS评分(75.39 ~ 32.75),P <ODI (65.30 ~ 27.66), P <0.001. 单纯腰椎减压手术后神经根痛的减轻程度大于腰痛(P = 0.03)。结论:无器械腰椎减压手术6个月后,有症状性DLSD和术前背痛评分高且无明显脱臼的患者,神经根和背部疼痛强度以及疼痛相关功能障碍均可显著降低。
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引用次数: 0
Reverse Y stenting in the management of vertebrobasilar junction fenestrated aneurysm: A novel technique 反向Y型支架置入治疗椎基底交界处开窗动脉瘤:一种新技术
Q3 Medicine Pub Date : 2023-10-31 DOI: 10.25259/jnrp_423_2023
Manoj Kumar Nayak, Biswajit Sahoo, Anshu Mahajan, Suprava Naik, Nerbadyswari Deep (Bag), Biswamohan Mishra, Chinmaya Dash
Fenestrated aneurysm at vertebrobasilar junction (VBJ) is very rare and can occur due to non-fusion of longitudinal neural axis forming basilar artery in the early stage of embryonic life. Due to defects in tunica media and weakness in its wall, these fenestrations are more likely to develop an aneurysm. Various treatment strategies are required for the management of these types of aneurysms including simple coiling, stent-assisted coiling, balloon remodeling technique, and more recently kissing flow diverters. Herein, we report the case of ruptured fenestrated VBJ aneurysm which was managed successfully with novel reverse Y stenting with coiling.
椎基底动脉连接处开窗动脉瘤(VBJ)是非常罕见的,可发生于胚胎早期形成基底动脉的纵向神经轴未融合。由于中膜的缺陷和壁的薄弱,这些开窗更容易形成动脉瘤。这些类型的动脉瘤需要多种治疗策略,包括简单的卷取、支架辅助卷取、球囊重塑技术以及最近的吻合器分流术。在此,我们报告了一例破裂的VBJ动脉瘤,并成功地处理了新型的反向Y型支架与卷绕。
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引用次数: 0
Scrub typhus with opsoclonus-myoclonus-ataxia-seizure as primary presentations 以阵挛-肌阵挛-共济失调-癫痫发作为主要表现的恙虫病
Q3 Medicine Pub Date : 2023-10-30 DOI: 10.25259/jnrp_314_2023
Sumirini Puppala, Abhijit Acharya, Surjyaprakash S. Choudhury
Scrub typhus is a simple acute febrile illness with rash or an eschar, with up to one-fifth of the patients complicated with the nervous system. Hence, certain cases present to physicians with rather a different systemic manifestation and incidentally have been diagnosed with scrub typhus. We present two such cases of scrub typhus with neurological manifestations. The first case was of a 14-year-old boy with no previous history of any comorbidities who presented with bilateral opsoclonus with multifocal spontaneous myoclonus with cerebellar ataxia with a preceding history of fever and acute gastroenteritis. The second case of a 30-year-old gentleman with no previous history of any comorbidities presented to us with generalized tonic-clonic seizures and spontaneous multifocal myoclonus with a preceding history of fever. Both cases had no motor, sensory, cerebellar, or autonomic involvement. The pathophysiology of central nervous system (CNS) infections in scrub typhus is attributed to three major mechanisms of vasculitis, direct invasion, and immune-mediated. CNS involvement in scrub typhus is a significant marker for risk of mortality or morbidity. The most common CNS manifestations in scrub include meningitis, encephalitis, and seizures. Opsoclonus, myoclonus, and parkinsonism are comparatively rare manifestations.Scrub typhus infection must be considered in the differential diagnosis of clinical neurological features with even a remote history of acute febrile illnesses in endemic regions like ours, despite the absence of any eschar, rashes, and unremarkable neuroimaging.
恙虫病是一种简单的急性发热性疾病,伴有皮疹或结痂,多达五分之一的患者伴有神经系统并发症。因此,某些病例呈现给医生相当不同的系统表现,并偶然被诊断为恙虫病。我们提出两个这样的病例与神经系统表现的丛林斑疹伤寒。第一例病例是一名14岁男孩,既往无任何合并症史,表现为双侧阵挛合并多灶自发性肌阵挛伴小脑性共济失调,既往有发热和急性胃肠炎史。第二例患者为30岁男性,既往无任何合并症,向我们报告全身性强直-阵挛性发作和自发性多灶性肌阵挛,既往有发热史。两例患者均无运动、感觉、小脑或自主神经受累。恙虫病中枢神经系统(CNS)感染的病理生理机制主要有血管炎、直接侵袭和免疫介导三种机制。恙虫病的中枢神经系统受累是死亡或发病风险的重要标志。最常见的中枢神经系统表现包括脑膜炎、脑炎和癫痫发作。眼阵挛、肌阵挛和帕金森症是比较罕见的表现。在临床神经学特征的鉴别诊断中必须考虑恙虫病感染,即使在像我们这样的流行地区有急性发热性疾病的遥远历史,尽管没有任何痂、皮疹和不显著的神经影像学。
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引用次数: 0
Association between multilingualism and cognitive performance among older adults in rural southern India 印度南部农村老年人使用多种语言与认知能力之间的关系
Q3 Medicine Pub Date : 2023-10-30 DOI: 10.25259/jnrp_376_2023
Anjana Jayakumar Menon, Palash Kumar Malo, Shubham Jain, Sandhya Gandhi, Jonas S. Sundarakumar, Pooja Rai, Thomas Gregor Issac
Objectives: Recent studies have shown that multilingualism may play an important role in enhancing cognitive health. The process of language acquisition constitutes a form of natural brain training, which in turn is hypothesized to increase neuroplasticity and hence, maintains the cognitive reserve. The study aimed to analyze the relationship between the number of languages known to an individual and its effect on cognitive functioning in both healthy and cognitively impaired study participants. Materials and Methods: This study utilized cross-sectional (baseline) data from Srinivasapura Aging, Neuro Senescence and COGnition study, which is an ongoing community-based, longitudinal aging cohort study conducted in a rural setting in southern India. A total of 3725 participants were considered for the study. The participants were separated into two groups, namely, monolinguals (participants knowing one language) and multilingual (participants knowing more than one language). The cognitive performance of the participants was assessed using the Clinical Dementia Rating (CDR) Scale. In addition, bivariate analyses and binary logistic regression analyses were carried out. Results: The result of CDR scores with respect to language category shows that, among the monolingual participants, 86.5% were healthy individuals and 13.5% were with mild cognitive impairment (MCI). Similarly, among the multilingual, 94.3% were healthy and 5.7% were with MCI. The odds ratio value derived from logistic regression (0.69 95% CI (0.5-0.9)) that an individual has a higher chance of developing cognitive impairment if he/she is a monolingual. Conclusion: This study highlights that knowing more than one language might have a profound positive impact on cognitive health, thereby reducing the likelihood of developing cognitive decline.
目的:最近的研究表明,使用多种语言可能在促进认知健康方面发挥重要作用。语言习得的过程构成了一种自然的大脑训练形式,这反过来又被假设为增加神经可塑性,从而保持认知储备。这项研究的目的是分析一个人知道的语言数量与它对健康和认知受损的研究参与者的认知功能的影响之间的关系。材料和方法:本研究利用了Srinivasapura衰老、神经衰老和认知研究的横断面(基线)数据,这是一项正在印度南部农村进行的以社区为基础的纵向老龄化队列研究。该研究共考虑了3725名参与者。参与者被分成两组,即单语者(参与者知道一种语言)和多语者(参与者知道一种以上的语言)。参与者的认知表现使用临床痴呆评分(CDR)量表进行评估。此外,还进行了双变量分析和二元逻辑回归分析。结果:语言类别CDR评分结果显示,单语参与者中86.5%为健康个体,13.5%为轻度认知障碍(MCI)。同样,在多语种人群中,94.3%的人健康,5.7%的人患有轻度认知障碍。逻辑回归得出的比值比值(0.69 95% CI(0.5-0.9))表明,单语者发生认知障碍的几率更高。结论:本研究强调,掌握一门以上的语言可能对认知健康产生深远的积极影响,从而减少认知能力下降的可能性。
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引用次数: 0
Phenotypic features of epilepsy due to sodium channelopathies – A single center experience from India 钠通道病变引起的癫痫的表型特征-来自印度的单中心经验
Q3 Medicine Pub Date : 2023-10-28 DOI: 10.25259/jnrp_329_2023
Lakshminarayanapuram Gopal Viswanathan, Sandhya Alapati, Madhu Nagappa, Ravindranadh Mundlamuri, Raghavendra Kenchaiah, Ajay Asranna, Hansashree Padmanabha, Doniparthi V. Seshagiri, Sanjib Sinha
Objectives: Nearly 40% of pediatric epilepsies have a genetic basis. There is significant phenotypic and genotypic heterogeneity, especially in epilepsy syndromes caused by sodium channelopathies. Sodium channel subunit 1A (SCN1A)-related epilepsy represents the archetypical channel-associated gene that has been linked to a wide spectrum of epilepsies of varying severity. Subsequently, other sodium channels have also been implicated in epilepsy and other neurodevelopmental disorders. This study aims to describe the phenotypes in children with sodium channelopathies from a center in Southern India. Materials and Methods: This is a retrospective, descriptive, and single-center study. Out of 112 children presenting with epilepsy who underwent genetic testing between 2017 and 2021, 23 probands (M: F = 12:11) were identified to have clinically significant sodium channel mutations. Clinical presentation, electroencephalography, and imaging features of these patients were recorded. The utility of genetic test results (e.g., in planning another child, withdrawal of medications, or change in treatment) was also recorded. Results: Age at onset of seizures ranged from day 4 of life to 3.5 years. Clinical epilepsy syndromes included generalized epilepsy with febrile seizures plus ( n = 3), Dravet syndrome ( n = 5), early infantile epileptic encephalopathy ( n = 7), drug-resistant epilepsy ( n = 5), and epilepsy with associated movement disorders ( n = 3). The most common type of seizure was focal with impaired awareness ( n = 18, 78.2%), followed by myoclonic jerks ( n = 8, 34.78%), epileptic spasms ( n = 7, 30.4%), bilateral tonic-clonic seizures/generalized tonic–clonic seizures ( n = 3, 13%), and atonic seizures ( n = 5, 23.8%). In addition to epilepsy, other phenotypic features that were discerned were microcephaly ( n = 1), cerebellar ataxia ( n = 2), and chorea and dystonia ( n = 1). Conclusion: Sodium channelopathies may present with seizure phenotypes that vary in severity. In addition to epilepsy, patients may also have other clinical features such as movement disorders. Early clinical diagnosis may aid in tailoring treatment for the given patient.
目的:近40%的儿童癫痫有遗传基础。在钠通道病引起的癫痫综合征中,存在显著的表型和基因型异质性。钠通道亚基1A (SCN1A)相关癫痫代表了典型的通道相关基因,该基因与各种严重程度的癫痫有关。随后,其他钠通道也与癫痫和其他神经发育障碍有关。本研究旨在描述来自印度南部一个中心的钠通道病儿童的表型。材料和方法:这是一项回顾性、描述性、单中心研究。在2017年至2021年期间接受基因检测的112名癫痫患儿中,有23名先证者(M: F = 12:11)被确定具有临床显著的钠通道突变。记录这些患者的临床表现、脑电图和影像学特征。还记录了基因检测结果的效用(例如,在计划另一个孩子、停药或改变治疗时)。结果:癫痫发作年龄从出生第4天到3.5岁不等。临床癫痫综合征包括全发性癫痫伴发热性癫痫发作(n = 3)、Dravet综合征(n = 5)、早期婴儿癫痫性脑病(n = 7)、耐药癫痫(n = 5)和癫痫伴运动障碍(n = 3)。最常见的癫痫类型为局灶性意识受损(n = 18, 78.2%),其次为肌阵挛性抽搐(n = 8, 34.78%)、癫痫性痉挛(n = 7, 30.4%)、癫痫性癫痫发作(n = 7, 30.4%)。双侧强直-阵挛性发作/全身性强直-阵挛性发作(n = 3, 13%)和失张力性发作(n = 5, 23.8%)。除癫痫外,其他表型特征还包括小头畸形(n = 1)、小脑性共济失调(n = 2)、舞蹈病和肌张力障碍(n = 1)。结论:钠通道病可能表现为癫痫发作表型,其严重程度不同。除癫痫外,患者还可能有其他临床特征,如运动障碍。早期临床诊断可能有助于为特定患者量身定制治疗。
{"title":"Phenotypic features of epilepsy due to sodium channelopathies – A single center experience from India","authors":"Lakshminarayanapuram Gopal Viswanathan, Sandhya Alapati, Madhu Nagappa, Ravindranadh Mundlamuri, Raghavendra Kenchaiah, Ajay Asranna, Hansashree Padmanabha, Doniparthi V. Seshagiri, Sanjib Sinha","doi":"10.25259/jnrp_329_2023","DOIUrl":"https://doi.org/10.25259/jnrp_329_2023","url":null,"abstract":"Objectives: Nearly 40% of pediatric epilepsies have a genetic basis. There is significant phenotypic and genotypic heterogeneity, especially in epilepsy syndromes caused by sodium channelopathies. Sodium channel subunit 1A (SCN1A)-related epilepsy represents the archetypical channel-associated gene that has been linked to a wide spectrum of epilepsies of varying severity. Subsequently, other sodium channels have also been implicated in epilepsy and other neurodevelopmental disorders. This study aims to describe the phenotypes in children with sodium channelopathies from a center in Southern India. Materials and Methods: This is a retrospective, descriptive, and single-center study. Out of 112 children presenting with epilepsy who underwent genetic testing between 2017 and 2021, 23 probands (M: F = 12:11) were identified to have clinically significant sodium channel mutations. Clinical presentation, electroencephalography, and imaging features of these patients were recorded. The utility of genetic test results (e.g., in planning another child, withdrawal of medications, or change in treatment) was also recorded. Results: Age at onset of seizures ranged from day 4 of life to 3.5 years. Clinical epilepsy syndromes included generalized epilepsy with febrile seizures plus ( n = 3), Dravet syndrome ( n = 5), early infantile epileptic encephalopathy ( n = 7), drug-resistant epilepsy ( n = 5), and epilepsy with associated movement disorders ( n = 3). The most common type of seizure was focal with impaired awareness ( n = 18, 78.2%), followed by myoclonic jerks ( n = 8, 34.78%), epileptic spasms ( n = 7, 30.4%), bilateral tonic-clonic seizures/generalized tonic–clonic seizures ( n = 3, 13%), and atonic seizures ( n = 5, 23.8%). In addition to epilepsy, other phenotypic features that were discerned were microcephaly ( n = 1), cerebellar ataxia ( n = 2), and chorea and dystonia ( n = 1). Conclusion: Sodium channelopathies may present with seizure phenotypes that vary in severity. In addition to epilepsy, patients may also have other clinical features such as movement disorders. Early clinical diagnosis may aid in tailoring treatment for the given patient.","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136231751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered behavior with an altered cell line 用改变的细胞系改变行为
Q3 Medicine Pub Date : 2023-10-27 DOI: 10.25259/jnrp_175_2023
Nikitha Elizabeth Mathews, Sowmya Gopalan, S. B. Prashanth Reddy
{"title":"Altered behavior with an altered cell line","authors":"Nikitha Elizabeth Mathews, Sowmya Gopalan, S. B. Prashanth Reddy","doi":"10.25259/jnrp_175_2023","DOIUrl":"https://doi.org/10.25259/jnrp_175_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136316856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does indirect decompression by oblique lateral interbody fusion produce similar clinical and radiological outcomes to direct decompression by open transforaminal lumbar interbody fusion 斜侧椎间融合术间接减压与经椎间孔开放腰椎椎间融合术直接减压的临床和影像学结果相似吗
Q3 Medicine Pub Date : 2023-10-27 DOI: 10.25259/jnrp_322_2023
Auroshish Sahoo, Mantu Jain, Suprava Naik, Gurudip Das, Pankaj Kumar, Sujit Kumar Tripathy, Harish V. K. Ratna, Mathan Kumar Ramasubbu
Objectives: Open transforaminal lumbar interbody fusion (O-TLIF) remains the most popular and widely practiced lumbar fusion method even today, providing direct decompression. Oblique lateral interbody fusion (OLIF) is a novel retroperitoneal approach that allows placement of a large interbody cage which provides an indirect neural decompression, and screws can be placed minimal invasively or through the Wiltse OLIF (W-OLIF) approach. We aim to find out the short-term efficacy of W-OLIF to O-TLIF in terms of radiological and clinical outcomes in patients of lumbar degenerative diseases. Materials and Methods: Fifty-two patients were divided equally into two groups (group O-TLIF and group W-OLIF). Several parameters were measured, such as the spinal cord cross-sectional area (SC-CSA), foraminal cross-sectional area (F-CSA), disc height (DH), foraminal height (FH), Schizas grade for stenosis, and Meyerding’s grading for olisthesis. Functional scores were measured using the visual analog scale (VAS) for low back pain (LBP) and lower limbs, Oswestry Disability Index. All parameters were repeat measured at 3 months follow-up. Statistical analysis was done using SPSS software. Results: Both groups were similar in composition preoperatively. There was significant improvement in all clinical and radiological parameters post-surgery in either group. However, at 3 months, The DH, FH, FSA, and VAS (LBP) were better in the W-OLIF group than in O-TLIF. Procedure-related complications were seen in both groups (15% in the O-TLIF group and 19% in the W-TLIF group), but only one patient in O-TLIF required revision due to cage migration. Conclusion: Similar improvement occurs in most of the clinical and radiological parameters in the W-OLIF group compared to the O-TLIF group. Few radiological parameters such as the DH, FH, and F-CSA and the VAS (LBP) correction are superior in the W-OLIF group in the short-term follow-up. We conclude that indirect decompression by W-OLIF provides equivalent, if not better, results than the traditional O-TLIF lumbar fusion.
目的:开放经椎间孔腰椎椎体间融合术(O-TLIF)即使在今天仍然是最流行和广泛应用的腰椎融合术,提供直接减压。斜侧体间融合术(OLIF)是一种新型的后腹膜入路,允许放置一个大的体间保持器,提供间接的神经减压,并且可以通过微创或Wiltse OLIF (W-OLIF)入路放置螺钉。我们的目的是了解W-OLIF对O-TLIF在腰椎退行性疾病患者放射学和临床预后方面的短期疗效。材料与方法:52例患者平均分为两组(O-TLIF组和W-OLIF组)。测量脊髓横截面积(SC-CSA)、椎间孔横截面积(F-CSA)、椎间盘高度(DH)、椎间孔高度(FH)、狭窄的Schizas分级和滑脱的Meyerding分级等参数。采用视觉模拟量表(VAS)测量腰痛(LBP)和下肢功能评分(Oswestry残疾指数)。随访3个月时重复测量各项参数。采用SPSS软件进行统计分析。结果:两组术前成分相近。两组患者术后临床及影像学指标均有显著改善。然而,在3个月时,W-OLIF组的DH、FH、FSA和VAS (LBP)优于O-TLIF组。两组均出现手术相关并发症(O-TLIF组为15%,W-TLIF组为19%),但O-TLIF组只有1例患者因笼型移位而需要翻修。结论:与O-TLIF组相比,W-OLIF组在大多数临床和放射学参数上都有类似的改善。在短期随访中,W-OLIF组的DH、FH、F-CSA和VAS (LBP)校正等放射学参数较少。我们得出结论,与传统的O-TLIF腰椎融合术相比,W-OLIF间接减压的效果即使不是更好,也是相当的。
{"title":"Does indirect decompression by oblique lateral interbody fusion produce similar clinical and radiological outcomes to direct decompression by open transforaminal lumbar interbody fusion","authors":"Auroshish Sahoo, Mantu Jain, Suprava Naik, Gurudip Das, Pankaj Kumar, Sujit Kumar Tripathy, Harish V. K. Ratna, Mathan Kumar Ramasubbu","doi":"10.25259/jnrp_322_2023","DOIUrl":"https://doi.org/10.25259/jnrp_322_2023","url":null,"abstract":"Objectives: Open transforaminal lumbar interbody fusion (O-TLIF) remains the most popular and widely practiced lumbar fusion method even today, providing direct decompression. Oblique lateral interbody fusion (OLIF) is a novel retroperitoneal approach that allows placement of a large interbody cage which provides an indirect neural decompression, and screws can be placed minimal invasively or through the Wiltse OLIF (W-OLIF) approach. We aim to find out the short-term efficacy of W-OLIF to O-TLIF in terms of radiological and clinical outcomes in patients of lumbar degenerative diseases. Materials and Methods: Fifty-two patients were divided equally into two groups (group O-TLIF and group W-OLIF). Several parameters were measured, such as the spinal cord cross-sectional area (SC-CSA), foraminal cross-sectional area (F-CSA), disc height (DH), foraminal height (FH), Schizas grade for stenosis, and Meyerding’s grading for olisthesis. Functional scores were measured using the visual analog scale (VAS) for low back pain (LBP) and lower limbs, Oswestry Disability Index. All parameters were repeat measured at 3 months follow-up. Statistical analysis was done using SPSS software. Results: Both groups were similar in composition preoperatively. There was significant improvement in all clinical and radiological parameters post-surgery in either group. However, at 3 months, The DH, FH, FSA, and VAS (LBP) were better in the W-OLIF group than in O-TLIF. Procedure-related complications were seen in both groups (15% in the O-TLIF group and 19% in the W-TLIF group), but only one patient in O-TLIF required revision due to cage migration. Conclusion: Similar improvement occurs in most of the clinical and radiological parameters in the W-OLIF group compared to the O-TLIF group. Few radiological parameters such as the DH, FH, and F-CSA and the VAS (LBP) correction are superior in the W-OLIF group in the short-term follow-up. We conclude that indirect decompression by W-OLIF provides equivalent, if not better, results than the traditional O-TLIF lumbar fusion.","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myasthenia gravis and numb chin syndrome with lung carcinoma 重症肌无力、颏麻木综合征伴肺癌
Q3 Medicine Pub Date : 2023-10-24 DOI: 10.25259/jnrp_387_2023
Rajesh Kumar Gupta, Ashutosh Gupta, Daniel S. Um, Zarrin Khameh Neda
{"title":"Myasthenia gravis and numb chin syndrome with lung carcinoma","authors":"Rajesh Kumar Gupta, Ashutosh Gupta, Daniel S. Um, Zarrin Khameh Neda","doi":"10.25259/jnrp_387_2023","DOIUrl":"https://doi.org/10.25259/jnrp_387_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distal vertebral artery pseudoaneurysm coiling using dual microcatheter “handshake” technique – A surgical challenge 使用双微导管“握手”技术缠绕远端椎动脉假性动脉瘤-一个外科挑战
Q3 Medicine Pub Date : 2023-10-24 DOI: 10.25259/jnrp_481_2023
Rohit Kamlesh Yadav, Shubhamitra Chaudhuri, Srikant Kumar Sundara, Prabhjyot Bir Singh Multani
{"title":"Distal vertebral artery pseudoaneurysm coiling using dual microcatheter “handshake” technique – A surgical challenge","authors":"Rohit Kamlesh Yadav, Shubhamitra Chaudhuri, Srikant Kumar Sundara, Prabhjyot Bir Singh Multani","doi":"10.25259/jnrp_481_2023","DOIUrl":"https://doi.org/10.25259/jnrp_481_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135315836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The profile of epilepsy and its characteristics in children with neurocutaneous syndromes 癫痫的概况及其特点在儿童神经皮肤综合征
Q3 Medicine Pub Date : 2023-10-19 DOI: 10.25259/jnrp_510_2023
Lokesh Saini, Swetlana Mukherjee, Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Chirag Ahuja, Indar Kumar Sharawat, Rajni Sharma, Ankita Bhati, Renu Suthar, Jitendra Kumar Sahu, Naveen Sankhyan
Objectives: The profile of seizures in neurocutaneous syndromes is variable. We aimed to define the characteristics of epilepsy in children with neurocutaneous syndromes. Materials and Methods: Cross-sectional study over 18 months at a tertiary care pediatric hospital, including children with neurocutaneous syndromes aged between 1 and 15 years, using the 2017-International League Against Epilepsy classification. Results: In 119 children with neurocutaneous syndromes, 94 (79%) had epilepsy. In eight children with neurofibromatosis one with epilepsy, 5 (62.5%) had generalized motor tonic-clonic seizures, 1 (12.5%) had generalized motor epileptic spasms, 1 (12.5%) had generalized motor automatism, and 1 (12.5%) had a focal seizure. In 69 children with tuberous sclerosis complex with epilepsy, 30 (43.5%) had generalized motor epileptic spasms, 23 (33.3%) had focal seizures, and nine (13.0%) had generalized motor tonic-clonic seizures. In 14 children with Sturge–Weber syndrome with epilepsy, 13 (92.8%) had focal seizures, and 1 (7.2%) had generalized motor tonic seizures. Statistically significant associations were found between epilepsy and intellectual disability ( P = 0.02) and behavioral problems ( P = 0.00). Conclusion: Profiling seizures in children with neurocutaneous syndromes are paramount in devising target-specific treatments as the epileptogenesis in each syndrome differs in the molecular pathways leading to the hyperexcitability state. Further multicentric studies are required to unravel better insights into the epilepsy profile of neurocutaneous syndromes.
目的:神经皮肤综合征的癫痫发作是可变的。我们的目的是确定癫痫的特点与神经皮肤综合征的儿童。材料和方法:在一家三级儿科医院进行为期18个月的横断面研究,包括1至15岁的神经皮肤综合征儿童,使用2017年国际抗癫痫联盟分类。结果:119例神经皮肤综合征患儿中,94例(79%)有癫痫。在8例神经纤维瘤病患儿中,1例伴有癫痫,5例(62.5%)有全身性运动性强直阵挛发作,1例(12.5%)有全身性运动性癫痫痉挛,1例(12.5%)有全身性运动自动性,1例(12.5%)有局灶性癫痫发作。69例结节性硬化症合并癫痫患儿中,30例(43.5%)有全身性运动性癫痫痉挛,23例(33.3%)有局灶性癫痫发作,9例(13.0%)有全身性运动性强直-阵挛性癫痫发作。在14例伴有斯特奇-韦伯综合征的癫痫患儿中,13例(92.8%)为局灶性癫痫发作,1例(7.2%)为全身性运动强直性癫痫发作。癫痫与智力障碍(P = 0.02)和行为问题(P = 0.00)有统计学意义的关联。结论:分析神经皮肤综合征儿童的癫痫发作对于设计靶向特异性治疗至关重要,因为每种综合征的癫痫发生在导致高兴奋状态的分子通路上是不同的。需要进一步的多中心研究来更好地了解神经皮肤综合征的癫痫概况。
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引用次数: 0
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Journal of Neurosciences in Rural Practice
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