P. Panda, Aman Elwadhi, Diksha Gupta, Achanya Palayullakandi, A. Tomar, Mayank Singh, Antara Vyas, Deepak Kumar, I. Sharawat
IMPUTE Inc., a software firm dedicated to healthcare technology, has developed a mobile medical application known as IMPUTE ADT-1 for children with autism spectrum disorder (ASD) based on the principle of applied behavior analysis. The primary objective of this trial was to compare the efficacy of add-on treatment with IMPUTE ADT-1 in children with ASD aged two to six years as compared to standard care alone for 12 weeks (in terms of change in Autism Diagnostic Observation Schedule [ADOS-2] scores). The secondary objective of the study was to assess the compliance with IMPUTE ADT-1 among participants and also to evaluate the feedback of parents regarding IMPUTE ADT-1 at the end of 12 weeks. The application provides personalized programs tailored to each user’s needs, and the program evolves based on the user’s progress. It also utilizes face tracking, eye tracking, and body tracking to gather behavior-related information for each child and apply it in reinforcement learning employing artificial intelligence-based algorithms. Till the time of interim analysis, 37 and 33 children had completed 12-week follow-up in IMPUTE ADT-1 and control arm. At 12 weeks, as compared to baseline, change in social affect domain, repetitive ritualistic behavior domain, total ADOS-2 score, and ADOS-2 comparison score was better in the intervention group as compared to the control group (P < 0.001 for all). A total of 30 (81%), 28 (75%), and 29 (78%) caregivers in the IMPUTE ADT-1 group believed that the ADT-1 app improved their child’s verbal skills, social skills, and reduced repetitive behavior, respectively. IMPUTE ADT-1 mobile application has the efficacy to improve the severity of autism symptoms in children. Parents of these children also feel that the application is beneficial for improving the socialization and verbal communication of their children.
{"title":"Effectiveness of IMPUTE ADT-1 mobile application in children with autism spectrum disorder: An interim analysis of an ongoing randomized controlled trial","authors":"P. Panda, Aman Elwadhi, Diksha Gupta, Achanya Palayullakandi, A. Tomar, Mayank Singh, Antara Vyas, Deepak Kumar, I. Sharawat","doi":"10.25259/jnrp_599_2023","DOIUrl":"https://doi.org/10.25259/jnrp_599_2023","url":null,"abstract":"\u0000\u0000IMPUTE Inc., a software firm dedicated to healthcare technology, has developed a mobile medical application known as IMPUTE ADT-1 for children with autism spectrum disorder (ASD) based on the principle of applied behavior analysis.\u0000\u0000\u0000\u0000The primary objective of this trial was to compare the efficacy of add-on treatment with IMPUTE ADT-1 in children with ASD aged two to six years as compared to standard care alone for 12 weeks (in terms of change in Autism Diagnostic Observation Schedule [ADOS-2] scores). The secondary objective of the study was to assess the compliance with IMPUTE ADT-1 among participants and also to evaluate the feedback of parents regarding IMPUTE ADT-1 at the end of 12 weeks. The application provides personalized programs tailored to each user’s needs, and the program evolves based on the user’s progress. It also utilizes face tracking, eye tracking, and body tracking to gather behavior-related information for each child and apply it in reinforcement learning employing artificial intelligence-based algorithms.\u0000\u0000\u0000\u0000Till the time of interim analysis, 37 and 33 children had completed 12-week follow-up in IMPUTE ADT-1 and control arm. At 12 weeks, as compared to baseline, change in social affect domain, repetitive ritualistic behavior domain, total ADOS-2 score, and ADOS-2 comparison score was better in the intervention group as compared to the control group (P < 0.001 for all). A total of 30 (81%), 28 (75%), and 29 (78%) caregivers in the IMPUTE ADT-1 group believed that the ADT-1 app improved their child’s verbal skills, social skills, and reduced repetitive behavior, respectively.\u0000\u0000\u0000\u0000IMPUTE ADT-1 mobile application has the efficacy to improve the severity of autism symptoms in children. Parents of these children also feel that the application is beneficial for improving the socialization and verbal communication of their children.\u0000","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
François de Paule D.K. Adjiou, E. Hakkou, Salma Abbas, Othmane El Manouni, Meriem Kajeou, A. El Ouahabi
Traumatic spondylolisthesis of the lumbosacral junction (SPL) is a spinal injury rarely seen in current practice. Few cases are reported in the literature. It arises from complex trauma of high-energy mechanisms. We discussed the case of a young patient. He is 24 years old without notable pathological history victim of a traffic road accident. Clinically, he has no sensory or motor deficit, it is a spinal trauma classified American spinal injury association E (ASIA E) with severe back pain. A whole-body CT scan performed on admission showed a grade 2 L5–S1 SPL. A lumbar MRI revealed a tear of the disc at L5–S1. We performed a laminectomy to decompress the dural sheath and cauda equina roots with transforaminal lumbar interbody fusion. A postoperative CT scan showed the reduction of the spondylolisthesis. Two months later, the patient resumed walking. Surgery is the gold standard for the management of traumatic SPL. The aim of surgery is to achieve neural structure decompression and obtain stability with fusion.
{"title":"Traumatic lumbar spondylolisthesis: A case report and review of literature","authors":"François de Paule D.K. Adjiou, E. Hakkou, Salma Abbas, Othmane El Manouni, Meriem Kajeou, A. El Ouahabi","doi":"10.25259/jnrp_330_2023","DOIUrl":"https://doi.org/10.25259/jnrp_330_2023","url":null,"abstract":"Traumatic spondylolisthesis of the lumbosacral junction (SPL) is a spinal injury rarely seen in current practice. Few cases are reported in the literature. It arises from complex trauma of high-energy mechanisms. We discussed the case of a young patient. He is 24 years old without notable pathological history victim of a traffic road accident. Clinically, he has no sensory or motor deficit, it is a spinal trauma classified American spinal injury association E (ASIA E) with severe back pain. A whole-body CT scan performed on admission showed a grade 2 L5–S1 SPL. A lumbar MRI revealed a tear of the disc at L5–S1. We performed a laminectomy to decompress the dural sheath and cauda equina roots with transforaminal lumbar interbody fusion. A postoperative CT scan showed the reduction of the spondylolisthesis. Two months later, the patient resumed walking. Surgery is the gold standard for the management of traumatic SPL. The aim of surgery is to achieve neural structure decompression and obtain stability with fusion.","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139841012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
François de Paule D.K. Adjiou, E. Hakkou, Salma Abbas, Othmane El Manouni, Meriem Kajeou, A. El Ouahabi
Traumatic spondylolisthesis of the lumbosacral junction (SPL) is a spinal injury rarely seen in current practice. Few cases are reported in the literature. It arises from complex trauma of high-energy mechanisms. We discussed the case of a young patient. He is 24 years old without notable pathological history victim of a traffic road accident. Clinically, he has no sensory or motor deficit, it is a spinal trauma classified American spinal injury association E (ASIA E) with severe back pain. A whole-body CT scan performed on admission showed a grade 2 L5–S1 SPL. A lumbar MRI revealed a tear of the disc at L5–S1. We performed a laminectomy to decompress the dural sheath and cauda equina roots with transforaminal lumbar interbody fusion. A postoperative CT scan showed the reduction of the spondylolisthesis. Two months later, the patient resumed walking. Surgery is the gold standard for the management of traumatic SPL. The aim of surgery is to achieve neural structure decompression and obtain stability with fusion.
{"title":"Traumatic lumbar spondylolisthesis: A case report and review of literature","authors":"François de Paule D.K. Adjiou, E. Hakkou, Salma Abbas, Othmane El Manouni, Meriem Kajeou, A. El Ouahabi","doi":"10.25259/jnrp_330_2023","DOIUrl":"https://doi.org/10.25259/jnrp_330_2023","url":null,"abstract":"Traumatic spondylolisthesis of the lumbosacral junction (SPL) is a spinal injury rarely seen in current practice. Few cases are reported in the literature. It arises from complex trauma of high-energy mechanisms. We discussed the case of a young patient. He is 24 years old without notable pathological history victim of a traffic road accident. Clinically, he has no sensory or motor deficit, it is a spinal trauma classified American spinal injury association E (ASIA E) with severe back pain. A whole-body CT scan performed on admission showed a grade 2 L5–S1 SPL. A lumbar MRI revealed a tear of the disc at L5–S1. We performed a laminectomy to decompress the dural sheath and cauda equina roots with transforaminal lumbar interbody fusion. A postoperative CT scan showed the reduction of the spondylolisthesis. Two months later, the patient resumed walking. Surgery is the gold standard for the management of traumatic SPL. The aim of surgery is to achieve neural structure decompression and obtain stability with fusion.","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139781359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ears of the lynx: A neuroradiological totemism","authors":"Akhil Sahib, Cankatika Choudhury","doi":"10.25259/jnrp_428_2023","DOIUrl":"https://doi.org/10.25259/jnrp_428_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ears of the lynx: A neuroradiological totemism","authors":"Akhil Sahib, Cankatika Choudhury","doi":"10.25259/jnrp_428_2023","DOIUrl":"https://doi.org/10.25259/jnrp_428_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Behera, Manoranjan Mohapatra, Palash Das, Anunya Reddy, Gummalla Gyandeep
{"title":"Retrograde thromboembolism and recurrent stroke in an adolescent boy with bilateral cervical rib","authors":"M. Behera, Manoranjan Mohapatra, Palash Das, Anunya Reddy, Gummalla Gyandeep","doi":"10.25259/jnrp_385_2023","DOIUrl":"https://doi.org/10.25259/jnrp_385_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Behera, Manoranjan Mohapatra, Palash Das, Anunya Reddy, Gummalla Gyandeep
{"title":"Retrograde thromboembolism and recurrent stroke in an adolescent boy with bilateral cervical rib","authors":"M. Behera, Manoranjan Mohapatra, Palash Das, Anunya Reddy, Gummalla Gyandeep","doi":"10.25259/jnrp_385_2023","DOIUrl":"https://doi.org/10.25259/jnrp_385_2023","url":null,"abstract":"","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139785001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anurag S. Srivastava, Yogesh Kaushik, Anmol Singh Randhawa, Bhawani Shankar Sharma, Gourav Goyal, T. Sherpa
A rare case of aneurysm of the lateral sacral artery is reported. This 46-year-old female presented with complaints of bowel and bladder incontinence and decreased perianal sensation for the past 15 months. She underwent laminectomy and diskectomy for the diagnosis of a prolapsed disk at peripheral hospital where the surgeon was confronted with a severe and unexpected hemorrhage, and surgery was aborted without effective treatment. Prior medical history includes hypertensive kidney disease with a renal transplant eight years ago. Magnetic resonance imaging and angiographic findings were suggestive of a lateral sacral artery aneurysm. Patient with a history of renal transplant and presenting with cauda equina require a more thorough assessment, and a differential of lateral sacral artery aneurysm should always be kept in mind. Our purpose is to report the pre-operative features of the lateral sacral artery aneurysm and its treatment modalities.
{"title":"Lateral sacral artery aneurysm","authors":"Anurag S. Srivastava, Yogesh Kaushik, Anmol Singh Randhawa, Bhawani Shankar Sharma, Gourav Goyal, T. Sherpa","doi":"10.25259/jnrp_335_2023","DOIUrl":"https://doi.org/10.25259/jnrp_335_2023","url":null,"abstract":"A rare case of aneurysm of the lateral sacral artery is reported. This 46-year-old female presented with complaints of bowel and bladder incontinence and decreased perianal sensation for the past 15 months. She underwent laminectomy and diskectomy for the diagnosis of a prolapsed disk at peripheral hospital where the surgeon was confronted with a severe and unexpected hemorrhage, and surgery was aborted without effective treatment. Prior medical history includes hypertensive kidney disease with a renal transplant eight years ago. Magnetic resonance imaging and angiographic findings were suggestive of a lateral sacral artery aneurysm. Patient with a history of renal transplant and presenting with cauda equina require a more thorough assessment, and a differential of lateral sacral artery aneurysm should always be kept in mind. Our purpose is to report the pre-operative features of the lateral sacral artery aneurysm and its treatment modalities.","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anurag S. Srivastava, Yogesh Kaushik, Anmol Singh Randhawa, Bhawani Shankar Sharma, Gourav Goyal, T. Sherpa
A rare case of aneurysm of the lateral sacral artery is reported. This 46-year-old female presented with complaints of bowel and bladder incontinence and decreased perianal sensation for the past 15 months. She underwent laminectomy and diskectomy for the diagnosis of a prolapsed disk at peripheral hospital where the surgeon was confronted with a severe and unexpected hemorrhage, and surgery was aborted without effective treatment. Prior medical history includes hypertensive kidney disease with a renal transplant eight years ago. Magnetic resonance imaging and angiographic findings were suggestive of a lateral sacral artery aneurysm. Patient with a history of renal transplant and presenting with cauda equina require a more thorough assessment, and a differential of lateral sacral artery aneurysm should always be kept in mind. Our purpose is to report the pre-operative features of the lateral sacral artery aneurysm and its treatment modalities.
{"title":"Lateral sacral artery aneurysm","authors":"Anurag S. Srivastava, Yogesh Kaushik, Anmol Singh Randhawa, Bhawani Shankar Sharma, Gourav Goyal, T. Sherpa","doi":"10.25259/jnrp_335_2023","DOIUrl":"https://doi.org/10.25259/jnrp_335_2023","url":null,"abstract":"A rare case of aneurysm of the lateral sacral artery is reported. This 46-year-old female presented with complaints of bowel and bladder incontinence and decreased perianal sensation for the past 15 months. She underwent laminectomy and diskectomy for the diagnosis of a prolapsed disk at peripheral hospital where the surgeon was confronted with a severe and unexpected hemorrhage, and surgery was aborted without effective treatment. Prior medical history includes hypertensive kidney disease with a renal transplant eight years ago. Magnetic resonance imaging and angiographic findings were suggestive of a lateral sacral artery aneurysm. Patient with a history of renal transplant and presenting with cauda equina require a more thorough assessment, and a differential of lateral sacral artery aneurysm should always be kept in mind. Our purpose is to report the pre-operative features of the lateral sacral artery aneurysm and its treatment modalities.","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dinesh Sridhar, Lakshmi Ramamoorthy, Sunil K. Narayan, Deepak Amalnath, H. Lalthanthuami, Sachit Ganapathy, Unnikrishnan Puliyakkuth
Stroke is a medical emergency, the leading cause of death, and a significant cause of disability in developing countries. The primary goals of stroke management focus on reducing disability, which needs prompt treatment in time. Fever, sugar-hyperglycemia, and swallowing (FeSS) bundle are a promising nurse-led composite for reducing disability and death. The present study aims to assess the effect of FeSS bundle care on disability, functional dependency, and death among acute stroke patients. A randomized controlled trial was conducted among 104 acute stroke patients, who were admitted within the first 48 h of stroke symptoms and had no previous neurological deficits. Randomization was stratified based on gender and type of stroke. The intervention group received FeSS bundle care, which included nurse-led fever and sugar management for the first 72 h, and a swallowing assessment done within the first 24 h or before the first oral meal. A follow-up assessment was done after 90 days to assess the disability, functional dependency, and mortality status using a modified Rankin scale and Barthel index. No significant difference was noted in the 90-day disability and functional dependency between the groups. A reduction in mortality was noted in the intervention group. The risk ratio for mortality between groups was 2.143 (95% confidence interval: 0.953–4.820). Although no significant reduction in disability, there was a reduction in mortality in the intervention group. Hence, the study suggested the promotion of nurse-led intervention using the FeSS bundle in stroke units.
{"title":"Effectiveness of nurse-led fever, sugar-hyperglycemia, and swallowing bundle care on clinical outcome of patients with stroke at a tertiary care center: A randomized controlled trial","authors":"Dinesh Sridhar, Lakshmi Ramamoorthy, Sunil K. Narayan, Deepak Amalnath, H. Lalthanthuami, Sachit Ganapathy, Unnikrishnan Puliyakkuth","doi":"10.25259/jnrp_446_2023","DOIUrl":"https://doi.org/10.25259/jnrp_446_2023","url":null,"abstract":"\u0000\u0000Stroke is a medical emergency, the leading cause of death, and a significant cause of disability in developing countries. The primary goals of stroke management focus on reducing disability, which needs prompt treatment in time. Fever, sugar-hyperglycemia, and swallowing (FeSS) bundle are a promising nurse-led composite for reducing disability and death. The present study aims to assess the effect of FeSS bundle care on disability, functional dependency, and death among acute stroke patients.\u0000\u0000\u0000\u0000A randomized controlled trial was conducted among 104 acute stroke patients, who were admitted within the first 48 h of stroke symptoms and had no previous neurological deficits. Randomization was stratified based on gender and type of stroke. The intervention group received FeSS bundle care, which included nurse-led fever and sugar management for the first 72 h, and a swallowing assessment done within the first 24 h or before the first oral meal. A follow-up assessment was done after 90 days to assess the disability, functional dependency, and mortality status using a modified Rankin scale and Barthel index.\u0000\u0000\u0000\u0000No significant difference was noted in the 90-day disability and functional dependency between the groups. A reduction in mortality was noted in the intervention group. The risk ratio for mortality between groups was 2.143 (95% confidence interval: 0.953–4.820).\u0000\u0000\u0000\u0000Although no significant reduction in disability, there was a reduction in mortality in the intervention group. Hence, the study suggested the promotion of nurse-led intervention using the FeSS bundle in stroke units.\u0000","PeriodicalId":16443,"journal":{"name":"Journal of Neurosciences in Rural Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139858133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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