Journal of Nuclear Cardiology最新文献

{"title":"Assessment of liver transplant candidates: What tests De-liver?","authors":"Robert C. Hendel MD, MASNC, MACC, FSCCT , Jason D. Stencel MD","doi":"10.1016/j.nuclcard.2025.102479","DOIUrl":"10.1016/j.nuclcard.2025.102479","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102479"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145334904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical and first-in-human studies of a novel tracer for single-photon emission computed tomography myocardial blood flow quantification","authors":"Yufan Gu MD ,&nbsp;Ruoxi Sun MD ,&nbsp;Wanjie Ren PhD ,&nbsp;Xiaoying Xi MD ,&nbsp;Kai Han MS ,&nbsp;Zongyao Zhang MS ,&nbsp;Shuang Liu PhD ,&nbsp;Wei Fang MD ,&nbsp;Lei Wang MD","doi":"10.1016/j.nuclcard.2025.102441","DOIUrl":"10.1016/j.nuclcard.2025.102441","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to develop a dedicated tracer with high first-pass extraction fraction and stable heart retention for single-photon emission computed tomography (SPECT) myocardial perfusion imaging and flow measurement.</div></div><div><h3>Methods</h3><div>Three ^99mTc-labeled compounds (^99mTc-4BOH, ^99mTc-3BOH, and ^99mTc-2BOH) were evaluated by mouse ex vivo distribution and swine planar imaging studies. ^99mTc-4BOH was identified as a candidate and compared with ^99mTc-Teboroxime and ^99mTc-Sestamibi in swine on cadmium zinc telluride SPECT to study organ uptake and kinetic properties. Head-to-head comparisons of ^99mTc-4BOH with ^99mTc-Sestamibi and ¹³N–NH₃ were performed on two separate pilot cohorts each comprising 10 patients.</div></div><div><h3>Results</h3><div>The myocardial uptake of ^99mTc-4BOH demonstrated significantly higher levels than ^99mTc-Sestamibi in swine and human, evidenced by higher <em>K</em>_<em>1</em> values (swine rest: .81 ± .03 mL/g/min vs .43 ± .09 mL/g/min, <em>P</em> &lt; .001; stress: 1.19 ± .26 mL/g/min vs .50 ± .10 mL/g/min, <em>P</em> &lt; .001; human rest: .74 ± .09 mL/g/min vs .38 ± .04 mL/g/min, <em>P</em> &lt; .001; stress 1.42 ± .17 mL/g/min vs .59 ± .07 mL/g/min, <em>P</em> &lt; .001). <em>k</em>_<em>2</em> values of ^99mTc-4BOH were lower than those of ^99mTc-Teboroxime (rest: .18 ± .03/min vs .26 ± .01/min, <em>P</em> &lt; .001; stress: .26 ± .04/min vs .38 ± .08/min, <em>P</em> &lt; .01), suggesting greater stability than ^99mTc-Teboroxime in the swine. Three- to 8-min data after injection are sufficient to produce high-quality perfusion images that offer clear visualization of the myocardium and minimal interference artifacts due to favorable heart-to-liver ratios of ^99mTc-4BOH. Furthermore, <em>K</em>_<em>1</em> values from ^99mTc-4BOH SPECT significantly correlated with ¹³N–NH₃ positron emission tomography myocardial blood flow (MBF) (ρ = .83 on per-patient level, <em>P</em> &lt; .001; ρ = .81 on per-vessel level, <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>^99mTc-4BOH exhibited an encouraging pharmacokinetic profile with high and relatively stable cardiac uptake. It constitutes a promising candidate as myocardial perfusion radiotracer for SPECT MBF quantification.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102441"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The power of participation: ASNC’s strength is YOU","authors":"Panithaya Chareonthaitawee MD, MASNC","doi":"10.1016/j.nuclcard.2025.102499","DOIUrl":"10.1016/j.nuclcard.2025.102499","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102499"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145334902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of rubidium-82 positron emission tomography in a multimodality approach to diagnosing coronary microvascular dysfunction in apical hypertrophic cardiomyopathy","authors":"Kutaiba Nazif DO ,&nbsp;A. Sami Abuzaid MD ,&nbsp;Stephen Horgan MB, BCh, PhD ,&nbsp;Krishna K. Patel MD, MSc ,&nbsp;Matthieu Pelletier-Galarneau MD, MBA, FASNC ,&nbsp;Tamara Naneishvili MD ,&nbsp;Gary Heller MD, PhD ,&nbsp;Parthiban Arumugam MD, FASNC","doi":"10.1016/j.nuclcard.2025.102197","DOIUrl":"10.1016/j.nuclcard.2025.102197","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102197"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PET-CT and CZT-SPECT on myocardial blood flow and flow reserve measurement: A systematic review and meta-analysis","authors":"Davi Shunji Yahiro ,&nbsp;Luís Felipe Leite ,&nbsp;Giovane L. Azevedo ,&nbsp;Mouaz H. Al-Mallah MD, MSc, MASNC ,&nbsp;Claudio Tinoco Mesquita MD, PhD, FASNC","doi":"10.1016/j.nuclcard.2025.102279","DOIUrl":"10.1016/j.nuclcard.2025.102279","url":null,"abstract":"<div><h3>Background</h3><div><span>Myocardial blood flow<span><span> (MBF) and myocardial flow<span><span> reserve (MFR) measurement is crucial for diagnosing and managing coronary artery disease and microvascular dysfunction. While </span>positron emission </span></span>tomography (PET) is the gold standard, </span></span>cadmium zinc telluride<span> (CZT) is more accessible. This systematic review and meta-analysis aim to compare the accuracy, and the systematic bias of MBF and MFR measurement using CZT compared with PET.</span></div></div><div><h3>Methods</h3><div>We conducted a systematic review<span> across multiple databases up to April 2024. The main outcomes were mean difference between MBF and MFR values obtained from PET and CZT, limits of agreement, and diagnostic performance. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool and statistical analysis was conducted using random effects models.</span></div></div><div><h3>Results</h3><div><span><span>Eight studies, encompassing 268 patients, met the inclusion criteria. The mean difference for rest and stress myocardial blood flow between PET and CZT was .006 (95% confidence interval [CI]: −.088, .100) and .111 (95% CI: −.418, .195), respectively. The </span>myocardial flow reserve mean difference was .0178 (95% CI: −.492, .135). Bland–Altman meta-analysis demonstrated a bias of .05 mL/min/g (95%CI: −1.08 to 1.24) for rest MBF, .13 mL/min/g for stress MBF (95%CI: −.969 to 1.228), and .03 mL/min/g (95%CI: −.999, 1.006) bias for MFR. The diagnostic performance for detecting significant reductions in MBF and MFR on single-photon emission computed </span>tomography using PET as the gold standard demonstrated sensitivity and specificity of 80.8% and 87.0%, respectively.</div></div><div><h3>Conclusions</h3><div>CZT MBF measurements demonstrated good agreement with PET, although they had a slight underestimation. While PET remains the preferred modality due to its superior performance, CZT represents a viable alternative when PET is unavailable. Future research should focus on standardizing CZT protocols.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102279"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved diagnostic performance of 18F-flurpiridaz positron emission tomography myocardial blood flow quantification with automated dynamic motion correction","authors":"Jennifer M. Renaud MSc ,&nbsp;Jonathan B. Moody PhD ,&nbsp;Michael D. Vanderver MSA, CNMT ,&nbsp;Alexis Poitrasson-Rivière PhD ,&nbsp;Christopher J. Buckley PhD ,&nbsp;Edward P. Ficaro PhD ,&nbsp;Venkatesh L. Murthy MD, PhD","doi":"10.1016/j.nuclcard.2025.102450","DOIUrl":"10.1016/j.nuclcard.2025.102450","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102450"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new single-photon emission computed tomography blood flow tracer? Perhaps, but a long journey ahead","authors":"James A. Case PhD, MASNC","doi":"10.1016/j.nuclcard.2025.102475","DOIUrl":"10.1016/j.nuclcard.2025.102475","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102475"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145334546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What if SPECT could do it all?","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102510","DOIUrl":"10.1016/j.nuclcard.2025.102510","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102510"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145334901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Priming with specific context improves large language model performance on nuclear cardiology board preparation test","authors":"Waseem Hijazi MD ,&nbsp;Valerie Builoff BS ,&nbsp;Aditya Killekar MSc ,&nbsp;Aakash Shanbhag MSc ,&nbsp;Robert J.H. Miller MD ,&nbsp;Damini Dey PhD ,&nbsp;Joanna X. Liang MPH ,&nbsp;Kathleen Flood BS ,&nbsp;Daniel Berman MD ,&nbsp;Jamieson M. Bourque MD, MHS ,&nbsp;Lawrence M. Phillips MD, MASNC ,&nbsp;Panithaya Chareonthaitawee MD ,&nbsp;Piotr J. Slomka PhD, MASNC","doi":"10.1016/j.nuclcard.2025.102269","DOIUrl":"10.1016/j.nuclcard.2025.102269","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102269"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blunted hemodynamic response to pharmacological stress is predictive of mortality in liver transplant candidates","authors":"Ibolya Csecs MD, PhD ,&nbsp;Aakanksha Sharma MBBS ,&nbsp;Vandana Khungar MD, MSc ,&nbsp;Albert J. Sinusas MD ,&nbsp;Stephen Possick MD ,&nbsp;Edward J. Miller MD, PhD ,&nbsp;Attila Feher MD, PhD","doi":"10.1016/j.nuclcard.2025.102454","DOIUrl":"10.1016/j.nuclcard.2025.102454","url":null,"abstract":"<div><h3>Background</h3><div>The optimal method for evaluating coronary artery disease in liver transplant candidates (LTCs) remains controversial. To date no studies have compared the hemodynamic and symptomatic response to vasodilator stress between LTCs and patients without chronic liver disease.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of LTCs who underwent regadenoson nuclear stress testing with either ^99mTc-tetrofosmin single-photon emission computed tomography (SPECT; N = 224) or ⁸²Rubidium positron emission tomography (N = 36). These patients were compared to controls matched for age, sex, body mass index, cardiovascular comorbidities, and imaging modality who underwent clinically indicated regadenoson stress test.</div></div><div><h3>Results</h3><div>LTCs were less likely to experience symptoms in response to regadenoson than controls (65% vs 86 %, <em>P</em> &lt; .001). Additionally, the increase in heart rate was blunted in LTCs (ΔHR: 13 beats per minute [bpm], interquartile range [IQR]: 11-15 vs 29 bpm, IQR: 27-31, <em>P</em> &lt; .001). During the median follow-up period of 2.0 ± 1.5 years, 78 deaths occurred in LTCs. In the multivariable analysis, ΔHR (hazard ratio [HZR]: .975, 95% confidence interval [CI]: .951–.999, <em>P</em> = .042) and changes in diastolic blood pressure (ΔDBP, HZR: 1.037, 95% CI: 1.003-1.071, <em>P</em> = .031) were significantly associated with mortality regardless of Model for End-stage Liver Disease (MELD) score, age, cardiovascular comorbidities, and stress test results. In addition, LTCs with both high MELD score (≥15) and low ΔHR (≤10 bpm) had worse overall survival than patients with a low MELD score (&lt;15) and high ΔHR (&gt;10 bpm, HZR: 5.54, 95% CI: 3.21-9.53, <em>P</em> &lt; .001), low MELD score and low ΔHR (HZR: 6.62, 95% CI: 3.25-13.49, <em>P</em> &lt; .001), and high MELD score and low ΔHR (HZR: 2.91, 95% CI: 1.50-5.64, <em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>In this retrospective cohort analysis, LTCs exhibited a reduced hemodynamic response detected as lower ΔHR as well as fewer symptoms in response to regadenoson during stress testing. Reduced hemodynamic response was significantly associated with mortality and provided incremental prognostic value in addition to MELD score. Further prospective studies are required to validate these findings.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"52 ","pages":"Article 102454"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}