Journal of Nuclear Cardiology最新文献

{"title":"Washout rate of cardiac ¹²³I-meta-iodobenzylguanidine and ischemic stroke outcome.","authors":"Sylvie De Raedt, Ilse Peeters, Geraldine Vanderschueren, Amber Nous, Sophie Bourgeois, Fenne Vandervorst, Jacques De Keyser, Kenichi Nakajima, Hein J Verberne","doi":"10.1016/j.nuclcard.2024.102105","DOIUrl":"10.1016/j.nuclcard.2024.102105","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102105"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-photon emission computed tomography/computed tomography quantification of Tc-99m pyrophosphate uptake to assess tafamidis treatment response in transthyretin cardiac amyloidosis","authors":"Carlos Godoy-Rivas MD ,&nbsp;Mohammed Elsadany MD ,&nbsp;Abhishek Jaiswal MD,&nbsp;Adaya Weissler-Snir MD,&nbsp;Sabeena Arora MD,&nbsp;W. Lane Duvall MD","doi":"10.1016/j.nuclcard.2024.102056","DOIUrl":"10.1016/j.nuclcard.2024.102056","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac imaging with bone-avid tracers for the diagnosis of transthyretin amyloid (ATTR) cardiac amyloidosis uses only limited quantification, but single-photon emission computed tomography/computed tomography (SPECT/CT) acquisition can provide volumetric assessment with quantification of tracer uptake. Tafamidis is routinely used in the treatment of cardiac amyloidosis, but there are scant data on changes in imaging results during therapy. The purpose of this study was to perform a longitudinal assessment of Tc-99m-pyrophosphate (PYP) imaging to determine if tafamidis therapy results in any change in quantitative measures of tracer uptake.</div></div><div><h3>Methods</h3><div>The study incorporated a prospective, single-center study of ATTR patients being treated with tafamidis using Tc-99m-PYP SPECT/CT to quantify cardiac tracer uptake in the whole heart and left ventricle. Standardized uptake values (SUVs) were adjusted for blood pool activity. Comparison of baseline activity was made to values obtained approximately every 6 months during treatment.</div></div><div><h3>Results</h3><div>Twenty-two patients (77.0<!--> <!-->±<!--> <!-->7.5 years old, 86.4% male) were on tafamidis for 15.3<!--> <!-->±<!--> <!-->4.0 months, with an average time between baseline and final follow-up study of 16.8<!--> <!-->±<!--> <!-->4.7 months. Thirteen patients (59.1%) had multiple follow-up amyloid studies. Statistically significant reductions in total SUVs, SUV volume, and percentage of injected dose were seen. Adjusted for the maximal aortic SUV, the total SUV in the left ventricle decreased by 36.9%, the SUV volume by 38.7%, and the percentage of injected dose decreased by 34.9% (all <em>P</em> values<!--> <!-->≤<!--> <!-->0.0001). Over the study duration, there was a decrease of 7.7%/month in the measured metrics.</div></div><div><h3>Conclusion</h3><div>The quantitative SUV measurements from Tc-99m-PYP SPECT/CT revealed an overall decrease in scintographic amyloid burden during the course of tafamidis therapy, but additional work is needed to determine the optimal metrics and improve the reproducibility of the quantification.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102056"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do changes in myocardial bone-avid radiotracer uptake mean in transthyretin cardiac amyloidosis?","authors":"Olivier F. Clerc MD, MPH ,&nbsp;Sarah A.M. Cuddy MD, MPH ,&nbsp;Sharmila Dorbala MD, MPH","doi":"10.1016/j.nuclcard.2024.102077","DOIUrl":"10.1016/j.nuclcard.2024.102077","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102077"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thank you to our 2024 Reviewers","authors":"","doi":"10.1016/j.nuclcard.2024.102124","DOIUrl":"10.1016/j.nuclcard.2024.102124","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102124"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-head comparison of 18F-sodium fluoride coronary PET imaging between a silicon photomultiplier with digital photon counting and conventional scanners","authors":"Hidenobu Hashimoto MD, PhD ,&nbsp;Keiichiro Kuronuma MD, PhD ,&nbsp;Mark C. Hyun CNMT ,&nbsp;Donghee Han MD ,&nbsp;Valerie Builoff BSc ,&nbsp;Sebastian Cadet MSc ,&nbsp;Damini Dey PhD ,&nbsp;Daniel S. Berman MD ,&nbsp;Jacek Kwiecinski MD, PhD ,&nbsp;Piotr J. Slomka PhD","doi":"10.1016/j.nuclcard.2024.102045","DOIUrl":"10.1016/j.nuclcard.2024.102045","url":null,"abstract":"<div><h3>Background</h3><div>We compared silicone photomultipliers with digital photon counting (SiPM) and photomultiplier tubes (PMT) positron emission tomography (PET) in imaging coronary plaque activity with ¹⁸F-sodium fluoride (¹⁸F–NaF) and evaluated comprehensively SiPM PET reconstruction settings.</div></div><div><h3>Methods</h3><div>In 25 cardiovascular disease patients (mean age 67 ± 12 years), we conducted ¹⁸F–NaF PET on a SiPM (Biograph Vision) and conventional PET (Discovery 710) on the same day as part of a prospective clinical trial (NCT03689946). Following administration of 250 MBq of ¹⁸F–NaF, patients underwent a contrast-enhanced CT angiography and a 30-min PET acquisition in list-mode on each PET consecutively. Image noise was defined as mean standard deviation of blood pool activity within the left atria. Target-to-background ratio (TBR) and signal-to-noise ratio (SNR) were measured within the whole-vessel tubular three-dimensional volumes of interest on the cardiac motion and attenuation-corrected ¹⁸F–NaF PET images using dedicated software.</div></div><div><h3>Results</h3><div>There were significant differences in image noise and background activity between the two PETs (Image noise (%), PMT: 7.6 ± 3.7 vs SiPM: 4.0 ± 2.3, <em>P</em> &lt; 0.001; background activity, PMT: 1.4 ± 0.4 vs SiPM: 1.0 ± 0.3, <em>P</em> &lt; 0.001). Similarly, the SNR and TBR were significantly higher in vessels scanned with the SiPM PET (SNR, PMT: 16.3 ± 11.5 vs SiPM: 32.7 ± 29.8, <em>P</em> &lt; 0.001; TBR, PMT: 0.8 ± 0.4 vs SiPM: 1.1 ± 0.6, <em>P</em> &lt; 0.001). SiPM PET image reconstruction with a 256 matrix, 1.4 mm pixel, and 2 mm Gaussian filter provided best trade off in terms of maximal SNR, TBR, and clinically practical file size.</div></div><div><h3>Conclusions</h3><div>In ¹⁸F–NaF coronary PET imaging, the SiPM PET showed superior image contrast and less image noise compared with PMT PET.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102045"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The tipping point and nuclear cardiology: Building a field for the future","authors":"Lawrence M. Phillips MD, MASNC","doi":"10.1016/j.nuclcard.2024.102074","DOIUrl":"10.1016/j.nuclcard.2024.102074","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102074"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated deep learning segmentation of cardiac inflammatory FDG PET","authors":"Alexis Poitrasson-Rivière PhD ,&nbsp;Michael D. Vanderver MSA, CNMT ,&nbsp;Tomoe Hagio PhD ,&nbsp;Liliana Arida-Moody BS ,&nbsp;Jonathan B. Moody PhD ,&nbsp;Jennifer M. Renaud MSc ,&nbsp;Edward P. Ficaro PhD ,&nbsp;Venkatesh L. Murthy MD, PhD","doi":"10.1016/j.nuclcard.2024.102052","DOIUrl":"10.1016/j.nuclcard.2024.102052","url":null,"abstract":"<div><h3>Background</h3><div>Fluorodeoxyglucose positron emission tomography (FDG PET) with suppression of myocardial glucose utilization plays a pivotal role in diagnosing cardiac sarcoidosis. Reorientation of images to match perfusion datasets and myocardial segmentation enables consistent image scaling and quantification. However, such manual tasks are cumbersome. We developed a 3D U-Net deep-learning (DL) algorithm for automated myocardial segmentation in cardiac sarcoidosis FDG PET.</div></div><div><h3>Methods</h3><div>The DL model was trained on FDG PET scans from 316 patients with left ventricular contours derived from paired perfusion datasets. Qualitative analysis of clinical readability was performed to compare DL segmentation with the current automated method on a 50-patient test subset. Additionally, left ventricle displacement and angulation, as well as SUVmax sampling were compared with inter-user reproducibility results. A hybrid workflow was also investigated to accelerate study processing time.</div></div><div><h3>Results</h3><div>DL segmentation enhanced readability scores in over 90% of cases compared with the standard segmentation currently used in the software. DL segmentation performed similar to a trained technologist, surpassing standard segmentation for left ventricle displacement and angulation, as well as correlation of SUVmax. Using the DL segmentation as initial placement for manual segmentation significantly decreased the processing time.</div></div><div><h3>Conclusion</h3><div>A novel DL-based automated segmentation tool markedly improves processing of cardiac sarcoidosis FDG PET. This tool yields optimized splash display of sarcoidosis FDG PET datasets with no user input and offers significant processing time improvement for manual segmentation of such datasets.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102052"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental prognostic value of 18F-fluorodeoxyglucose myocardial ischemic memory imaging for major adverse cardiovascular events in patients with suspected unstable angina","authors":"Feifei Zhang MD ,&nbsp;Xiaoyu Yang MD ,&nbsp;Yongjun Chen MD ,&nbsp;Xiaoliang Shao MD ,&nbsp;Jianfeng Wang MD ,&nbsp;Sheng Zhang MD ,&nbsp;Guiliang Shi MD ,&nbsp;Minfu Yang PhD ,&nbsp;Zhifang Wu PhD ,&nbsp;Sijin Li PhD ,&nbsp;Yuetao Wang MD","doi":"10.1016/j.nuclcard.2024.102051","DOIUrl":"10.1016/j.nuclcard.2024.102051","url":null,"abstract":"<div><h3>Background</h3><div>The additional prognostic value of ^{18F-flurodeoxyglucose} positron emission tomography (¹⁸F-FDG PET) myocardial ischemic memory imaging for patients with suspected unstable angina (UA) is not well established. This study aimed to determine whether ¹⁸F-FDG PET imaging provides incremental prognostic information for predicting major adverse cardiac events (MACEs) compared to clinical risk factors, Global Registry of Acute Coronary Events (GRACE) score, and coronary artery calcium score (CACS) in patients with suspected UA.</div></div><div><h3>Methods</h3><div>In this post hoc analysis of a prospective study, 265 patients suspected with UA (62.3% male, mean age: 65.0<!--> <!-->±<!--> <!-->9.4 years) were enrolled. ¹⁸F-FDG positivity was defined as focal or focal on diffuse uptake patterns. MACEs included cardiovascular death, acute myocardial infarction, heart failure, rehospitalization for UA, and stroke. Multivariable Cox regression was used to identify predictors of MACEs, and the incremental prognostic value of ¹⁸F-FDG PET imaging was assessed using the Concordance Index (C-index), net reclassification improvement (NRI), and integrated discrimination improvement (IDI).</div></div><div><h3>Results</h3><div>Over a median follow-up of 25 months, 51 patients (19.2%) experienced MACEs. ¹⁸F-FDG positivity (hazard ratio [HR]<!--> <!-->=<!--> <!-->3.220, 95% confidence interval [CI]: 1.630-6.360, <em>P</em> <!-->&lt;<!--> <!-->.001), as well as ¹⁸F-FDG standardized uptake ratio (HR<!--> <!-->=<!--> <!-->1.330, 95% CI: 1.131–1.564, <em>P</em> <!-->=<!--> <!-->.0006) and Extent (HR<!--> <!-->=<!--> <!-->1.045, 95% CI: 1.028-1.062, <em>P</em> <!-->&lt;<!--> <!-->.0001), were independent predictors of MACE. The addition of ¹⁸F-FDG PET imaging significantly improved risk stratification beyond clinical factors, the GRACE score, and CACS, with improved C-index (.769 vs .688, <em>P</em> <!-->=<!--> <!-->.045), NRI (.324, <em>P</em> <!-->=<!--> <!-->.020), and IDI (.055, <em>P</em> <!-->=<!--> <!-->.027).</div></div><div><h3>Conclusion</h3><div>¹⁸F-FDG PET myocardial ischemic memory imaging significantly improves prognostic assessment for patients with suspected UA, providing valuable additional risk stratification beyond clinical risk factors, GRACE score, and CACS.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102051"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automation is crucial for precision medicine","authors":"R. Glenn Wells PhD,&nbsp;Terrence D. Ruddy MD, MASNC","doi":"10.1016/j.nuclcard.2024.102090","DOIUrl":"10.1016/j.nuclcard.2024.102090","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102090"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional variation in technetium pyrophosphate (PYP) uptake in transthyretin cardiac amyloidosis (ATTR-CA) and concomitant myocardial infarction: A case series","authors":"Simrat Kaur,&nbsp;Fatimah Chamseddine,&nbsp;Bryan Abadie,&nbsp;Vikas Sunder,&nbsp;Wael Jaber","doi":"10.1016/j.nuclcard.2024.102031","DOIUrl":"10.1016/j.nuclcard.2024.102031","url":null,"abstract":"<div><div>- Diffuse and patchy myocardial uptake of Tc-99m PYP is well established in cases of ATTR-CA.</div><div>- Chronic myocardial infarction leads to regional myocardial thinning and lack of vascular supply can present as regional sparing ‘cold spot’ on Tc-99m PYP imaging.</div><div>- The absence of Tc-99m PYP uptake in vascular regions should raise the possibility of underlying scar.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"42 ","pages":"Article 102031"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}