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Improved risk stratification with noninvasive measures of myocardial flow reserve by low-dose dynamic imaging by cadmium-zinc-telluride-single photon emission computerized tomography in patients with suspected or known coronary artery disease. 在疑似或已知冠心病患者中,采用CZT-SPECT低剂量动态成像无创测量心肌血流储备改善风险分层。
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-20 DOI: 10.1016/j.nuclcard.2025.102564
Roberta Assante, Emilia Zampella, Adriana D'Antonio, Teresa Mannarino, Mariarosaria Panico, Valeria Cantoni, Roberta Green, Pietro Buongiorno, Alberto Cuocolo, Wanda Acampa
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引用次数: 0
Plaque, stenosis, and ischemia: A complex relationship 斑块、狭窄和缺血:一个复杂的关系
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102509
Friederike K. Keating MD, FACC, FASNC
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引用次数: 0
On the complexity of myocardial blood flow quantification: A never-ending story? 心肌血流定量的复杂性:一个永无止境的故事?
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102476
Stephan G. Nekolla PhD FESC , Susan Notohamiprodjo MD
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引用次数: 0
SNMMI/EANM/ASNC/ACNM procedure standard/practice guideline for 18F-Flurpiridaz PET myocardial perfusion imaging and blood flow quantitation SNMMI/EANM/ASNC/ACNM 18F-Flurpiridaz PET心肌灌注成像及血流量定量程序标准/实施指南
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102473
René R. Sevag Packard MD, PhD , Jamshid Maddahi MD , Matthieu Pelletier-Galarneau MD , Mouaz H. Al-Mallah MD, MSc , Marta Coelho , Sharmila Dorbala MD, MPH , James Galt PhD , Mark Hyun CNMT, NCT, RS, RT (N,R,CT) , Nandakumar Menon MD , Edward J. Miller MD, PhD , Mrinali Shetty MD , Antti Saraste MD, PhD
The Society of Nuclear Medicine and Molecular Imaging (SNMMI), founded in 1954 and headquartered in Reston, Virginia, USA, is a nonprofit scientific and professional organization that promotes the science, technology, and practical application of nuclear medicine and molecular imaging. SNMMI strives to be a leader in unifying, advancing, and optimizing molecular imaging with the ultimate goal of improving human health. With 13,000 members worldwide, SNMMI represents nuclear and molecular imaging professionals, all of whom are committed to the advancement of the field. The European Association of Nuclear Medicine (EANM) is a professional, nonprofit medical association that facilitates communication worldwide between individuals pursuing clinical and research excellence in nuclear medicine. The EANM was founded in 1985. The American College of Nuclear Medicine (ACNM) is a professional organization providing education, training, and advocacy for the most sought-after and trusted experts in nuclear medicine who deliver state-of-the-art and innovative care and service to patients and referring physicians. The ACNM's mission is to foster the highest standards in nuclear medicine consultation and service to referring physicians, hospitals, and the public, and to advance the science of nuclear medicine through a program of continuing professional development emphasizing high standards of nuclear medicine practice. The American Society of Nuclear Cardiology (ASNC) is the international home for nuclear cardiology and the largest professional society devoted exclusively to the field. ASNC membership includes more than 5700 nuclear cardiology professionals from around the world. Founded in 1993, ASNC's mission is to improve cardiovascular outcomes through image-guided patient management. ASNC's official publication is the Journal of Nuclear Cardiology.
The SNMMI/EANM/ACNM will periodically define new standards/guidelines for nuclear medicine practice to help advance the science of nuclear medicine and to improve the quality of service to patients. Existing standards/guidelines will be reviewed for revision or renewal, as appropriate, on their fifth anniversary or sooner, if indicated.
Each standard/guideline, representing a policy statement by the SNMMI/EANM/ACNM, has undergone a thorough consensus process in which it has been subjected to extensive review. The SNMMI, EANM, and ACNM recognize that the safe and effective use of diagnostic nuclear medicine imaging and therapy requires specific training, skills, and techniques, as described in each document. This document was jointly developed with ASNC. ASNC endorses this guideline, and it will be published alongside the Journal of Nuclear Medicine in the Journal of Nuclear Cardiology.
The SNMMI, EANM, ASNC, and ACNM have written and approved these standards/guidelines to promote the use of high-quality nuclear medicine procedures. These standards/guide
质量控制和改进、安全、感染控制和患者教育问题见SNMMI一般影像学指南。应根据良好的质量控制规范制定和实施与质量、患者教育、感染控制和安全相关的政策和程序。质量控制也应定期进行,以确保一致,准确的医生解释结果。设备性能监测应按照认可的认证机构进行。文件/报告见通用成像SNMMI指南,了解文件/报告要求。辐射安全成像见SNMMI一般成像指南。SNMMI的立场是,患者暴露于电离辐射的最低水平应与获得诊断检查相一致。当用于成像的技术或设备能够支持这种行动时,可以通过施用较少的放射性药物来减少患者的辐射暴露。每个病人的手术过程都是独一无二的,在保持诊断准确性的同时实现最小暴露的方法需要从这个角度来看待。本文件中概述的放射性药物活性范围应被视为指南。在适当情况下应采用减量技术。当CT用于混合成像程序时,应应用相同的原则。应优化CT采集方案,以提供所需的信息,同时尽量减少患者的辐射暴露。尽量减少辐射剂量对儿童尤其重要。母乳喂养患者参见同位素医学用途咨询委员会(ACMUI)指南。
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引用次数: 0
Artificial intelligence–enabled parametric mapping of myocardial blood flow with 82Rb positron emission tomography compared to 18F-flurpiridaz perfusion imaging: A paired pilot study of image quality 人工智能支持的82Rb PET心肌血流参数映射与18f -氟吡达兹灌注成像的比较:图像质量的配对先导研究。
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102531
Eric Moulton PhD , Laura Gagliano PhD , Sanaz Kaviani PhD , Ran Klein PhD , Robert deKemp PhD, MASNC , Matthieu Pelletier-Galarneau MD, MSc
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引用次数: 0
Ending the Either–Or debate: Hybrid imaging and AI redefine CAD evaluation 结束非此即彼的争论:混合成像和人工智能重新定义CAD评估
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102561
Marcelo F. Di Carli MD, MASNC
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引用次数: 0
Artificial intelligence–derived calcium score as a gate keeper for stress-only imaging: Glimmers of genius, not quite gold 人工智能衍生的钙评分作为压力成像的看门人:天才的微光,不完全是金子
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102503
Firas Al Badarin MD, MSc , Rupa Sanghani MD
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引用次数: 0
Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories 在供应缺血区域的主要心外膜冠状动脉之间,狭窄程度和斑块负荷不同。
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102470
Tanja Kero MD, PhD , Juhani Knuuti MD, PhD , Sarah Bär MD, PhD , Jeroen J. Bax MD, PhD , Antti Saraste MD, PhD, FESC , Teemu Maaniitty MD, PhD

Background

It is unclear whether coronary artery stenosis, plaque burden, and composition differ between major epicardial arteries supplying ischemic myocardial territories.

Methods

We studied 837 symptomatic patients undergoing coronary computed tomography angiography (CTA) and 15O-water positron emission tomography (PET) myocardial perfusion imaging for suspected obstructive coronary artery disease. Coronary CTA was analyzed using artificial intelligence-guided quantitative computed tomography (AI-QCT) to assess stenosis and atherosclerotic plaque characteristics. Myocardial ischemia was defined by regional PET perfusion in the left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) territories.

Results

Among arteries supplying ischemic territories, the LAD exhibited significantly higher stenosis and both absolute and normalized plaque volumes compared to LCX and RCA (P < .001 for all). Multivariable logistic regression showed diameter stenosis (P = .001-.015), percent atheroma volume (PAV; P < .001), and percent noncalcified plaque volume (NCPV) (P = .001-.017) were associated with ischemia across all three arteries. Percent calcified plaque volume (CPV) was associated with ischemia only in the RCA (P = .001).

Conclusions

The degree of stenosis and atherosclerotic burden are significantly higher in the LAD as compared to LCX and RCA, both in epicardial coronary arteries supplying nonischemic or ischemic myocardial territories. In all the three main coronary arteries, both luminal narrowing and plaque burden are independent predictors of ischemia, where the plaque burden is mainly driven by noncalcified plaque. However, many vessels supplying ischemic territories have a relatively low degree of stenosis and plaque burden, especially in the LCX and RCA, limiting the ability of diameter stenosis and PAV to predict myocardial ischemia.
背景:目前尚不清楚供应缺血心肌区域的主要心外膜动脉的冠状动脉狭窄、斑块负荷和组成是否不同。方法与结果:对837例疑似冠状动脉阻塞性疾病的有症状患者行冠状动脉ct血管造影(CTA)和15O-water PET心肌灌注显像。使用人工智能引导的定量计算机断层扫描(AI-QCT)分析冠状动脉CTA以评估狭窄和动脉粥样硬化斑块特征。心肌缺血是通过左前降(LAD)、左旋(LCX)和右冠状动脉(RCA)区域PET灌注来定义的。在供应缺血区域的动脉中,与LCX和RCA相比,LAD表现出明显更高的狭窄程度,绝对斑块体积和标准化斑块体积(结论:在供应非缺血或缺血心肌区域的心外膜冠状动脉中,LAD的狭窄程度和动脉粥样硬化负担均明显高于LCX和RCA。在所有三条主要冠状动脉中,管腔狭窄和斑块负荷都是缺血的独立预测因子,其中斑块负荷主要由非钙化斑块驱动。然而,许多供应缺血区域的血管的狭窄程度和斑块负担相对较低,特别是在LCx和RCA,限制了直径狭窄和PAV预测心肌缺血的能力。
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引用次数: 0
Coronary anatomy matters: Dual LAD presenting as atypical ischemia on myocardial perfusion imaging 冠状动脉解剖学要点:双LAD在心肌灌注成像上表现为不典型缺血。
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102205
Raza Abbas Mahdi MD , Harpreet Singh MD , Janarthanan Ilangovan MBBS , Neelam Dahiya DM , Bhagwant Rai Mittal MD
Myocardial perfusion imaging is susceptible to imaging artifacts that may limit its clinical utility. One approach to differentiate true perfusion defects from artifacts involves examining the presence of perfusion abnormalities that align with the typical anatomy of coronary vessels. However, this approach may not be applicable in patients having coronary anomalies. We report a patient with dual LAD exhibiting isolated ischemia of the anteroseptal wall on MPI, resembling artifact typically observed in patients with LBBB. The present case highlights the importance of familiarity with variations in coronary anatomy, like dual LAD, to avoid misinterpretation of atypical perfusion defects observed in MPI.
心肌灌注成像容易受到成像伪影的影响,这可能限制其临床应用。鉴别真正的灌注缺陷和伪影的一种方法是检查与典型冠状血管解剖结构一致的灌注异常的存在。然而,这种方法可能不适用于有冠状动脉异常的患者。我们报告了一个双LAD患者在MPI上表现出孤立的室间隔壁缺血,类似于LBBB患者通常观察到的伪影。本病例强调了熟悉冠状动脉解剖变化的重要性,如双LAD,以避免误解MPI中观察到的非典型灌注缺陷。
{"title":"Coronary anatomy matters: Dual LAD presenting as atypical ischemia on myocardial perfusion imaging","authors":"Raza Abbas Mahdi MD ,&nbsp;Harpreet Singh MD ,&nbsp;Janarthanan Ilangovan MBBS ,&nbsp;Neelam Dahiya DM ,&nbsp;Bhagwant Rai Mittal MD","doi":"10.1016/j.nuclcard.2025.102205","DOIUrl":"10.1016/j.nuclcard.2025.102205","url":null,"abstract":"<div><div><span><span><span>Myocardial perfusion imaging<span> is susceptible to imaging artifacts that may limit its clinical utility. One approach to differentiate true perfusion defects from artifacts involves examining the presence of perfusion abnormalities that align with the typical anatomy of </span></span>coronary vessels. However, this approach may not be applicable in patients having </span>coronary anomalies. We report a patient with dual LAD exhibiting isolated </span>ischemia<span> of the anteroseptal wall on MPI, resembling artifact typically observed in patients with LBBB. The present case highlights the importance of familiarity with variations in coronary anatomy, like dual LAD, to avoid misinterpretation of atypical perfusion defects observed in MPI.</span></div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"53 ","pages":"Article 102205"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining pericardial cyst prevalence: A large-scale contemporary analysis 重新定义心包囊肿患病率:一项大规模的当代分析。
IF 2.7 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-11-01 DOI: 10.1016/j.nuclcard.2025.102453
Huda El Mais MD , Kaitlyn Granstaff MD , Cameron Quick , Caleb Haverstick , Randall C. Thompson MD, MACC
{"title":"Redefining pericardial cyst prevalence: A large-scale contemporary analysis","authors":"Huda El Mais MD ,&nbsp;Kaitlyn Granstaff MD ,&nbsp;Cameron Quick ,&nbsp;Caleb Haverstick ,&nbsp;Randall C. Thompson MD, MACC","doi":"10.1016/j.nuclcard.2025.102453","DOIUrl":"10.1016/j.nuclcard.2025.102453","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"53 ","pages":"Article 102453"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Nuclear Cardiology
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