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Journal of Nuclear Cardiology最新文献

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Comparative Evaluation of Large Language Models for Patient Guidance on Pyrophosphate Scintigraphy Results 焦磷酸盐闪烁扫描结果患者指导大语言模型比较评估
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.102004
Giovane L. Azevedo (Junior, Medical Student), Breno P. Potsch (Medical Student), Davi S. Yahiro (Medical Student), Luiza A. Ávila (Medical Student), Luiza M.R.S. Freitas (Medical Student), Vinícius A.M. Lutterbach (Medical Student), Claudio T. Mesquita MD, PhD, FASNC
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引用次数: 0
Splenic switch-off in [15O]H2O-positron emission tomography myocardial perfusion imaging using parametric blood flow images 使用参数血流图像进行[15O]H2O-PET 心肌灌注成像时的脾脏关闭。
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101868

Background

Evaluation of sufficient adenosine response constitutes a significant challenge in myocardial perfusion imaging (MPI). Splenic switch-off in MPI studies denotes a visually (qualitatively) reduced splenic radiotracer signal during adenosine stress and is considered indicative of sufficient cardiac vasodilation. In this study, we examined semi-quantitative and quantitative approaches to splenic switch-off assessment using [15O]H2O-PET with either summed activity images or calculated parametric splenic blood flow images.

Methods

Cohort 1: 90 clinical patients undergoing [15O]H2O MPI in whom adenosine response was considered clinically adequate were identified to characterize the corresponding splenic switch-off. Spleen stress/rest-ratio (SSR-ratio) was calculated as spleen stress signal intensity/spleen rest signal intensity on both summed activity and parametric blood flow images.

Cohort 2: Twenty-five patients with repeat MPI due to suspected insufficient adenosine response were identified to observe if splenic switch-off on the initial MPI could predict the outcome of the repeat MPI.

Cohort 3: Fifty-four patients who were considered adenosine responders on MPI and who had a coronary angiogram (CAG) follow-up within 3 months after MPI served as a separate validation group.

Results

Splenic switch-off was present in most patients with a clinically sufficient adenosine response (Cohort 1), illustrated by both visual (74.4%–86.7%), semi-quantitative (summed activity images) (85.6%), and quantitative (parametric blood flow images) (92.2%) evaluation, which corresponds to the distribution in patients with sufficient adenosine response and follow-up CAG (Cohort 3). In patients suspected of insufficient adenosine response on the initial MPI (Cohort 2), the repeat MPI only yielded different myocardial blood flow (MBF) results if the initial SSR-ratio was >0.90 on splenic parametric blood flow images.

Conclusion

quantitative splenic switch-off assessment on parametric blood flow images was superior to the semi-quantitative splenic switch-off approach. Patients with a suspected insufficient initial adenosine response and SSR-ratio >0.90 can benefit from a repeat MPI. Thus, the integration of quantitative splenic switch-off using parametric blood flow images in the evaluation of adenosine response may support future clinical decision-making.

背景:评估足够的腺苷反应是心肌灌注成像(MPI)的一大挑战。在 MPI 研究中,脾脏开关表示腺苷应激时脾脏放射性示踪剂信号的直观(定性)减少,被认为是心脏血管充分扩张的标志。在这项研究中,我们使用[15O]H2O-PET 与总和活动图像或计算参数脾血流图像,研究了半定量和定量评估脾关闭的方法:队列 1:确定 90 名接受[15O]H2O MPI 检查的临床患者,这些患者的腺苷反应在临床上被认为是充分的,以确定相应的脾脏关闭特征。脾脏应激/静息比(SSR-ratio)的计算方法是,在活动和参数血流图像上,脾脏应激信号强度/脾脏静息信号强度。研究组 2:确定了 25 名因怀疑腺苷反应不足而重复进行 MPI 的患者,以观察初次 MPI 的脾脏关闭是否能预测重复 MPI 的结果。研究组 3:54 名在 MPI 上被认为有腺苷反应且在 MPI 后 3 个月内进行过 CAG 随访的患者作为单独的验证组:结果:大多数临床上对腺苷有充分反应的患者(队列 1)都存在脾关闭现象,通过视觉(74.4%-86.7%)、半定量(总和活动图像)(85.6%)和定量(参数血流图像)(92.在首次 MPI 中怀疑腺苷反应不足的患者(队列 2)中,只有当脾脏参数血流图像上的初始 SSR 比率大于 0.90 时,重复 MPI 才会得出不同的 MBF 结果:结论:参数血流图像上的定量脾关闭评估优于半定量脾关闭方法。怀疑初始腺苷反应不足且 SSR 比值 > 0.90 的患者可从重复 MPI 中获益。因此,在评估腺苷反应时结合使用参数血流图像进行定量脾脏关闭可能有助于未来的临床决策。
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引用次数: 0
Strength in numbers: Advancing the clinical reality fibroblast activation protein imaging in cardiovascular disease 人多力量大:推进心血管疾病中的成纤维细胞活化蛋白成像临床实践。
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.102016
Johanna Diekmann MD, James T. Thackeray PhD
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引用次数: 0
Validation of Exponential Dosing for Rubidium-82 PET Imaging in Very Obese Patients 验证极度肥胖患者铷-82 PET 成像的指数剂量
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101984
Anahita Tavoosi MD , Harmy Thakar BSc , Kimberly Gardner RTNM , Rob S.B. Beanlands MD, MASNC , Gary R. Small MBChB, PhD , Robert A. deKemp PhD, MASNC
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引用次数: 0
Automatic Motion Correction for Myocardial Blood Flow Estimation Improves Diagnostic Performance for Coronary Artery Disease in 18F-Flurpiridaz PET-MPI 用于心肌血流估计的自动运动校正提高了 18F-Flurpiridaz PET-MPI 对冠状动脉疾病的诊断性能
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101970
Valerie Michelle Builoff BS , Cathleen Huang BA , Keiichiro Kuronuma MD, PhD , Chih-Chun Wei MS , Hidesato Fujito MD, PhD , Yuka Otaki MD, PhD , Serge D. Van Kriekinge PhD , Paul Kavanagh MS , Mark Lemley BS , Mark C. Hyun CNMT, NCT, RT(N)(R), FASNC , Daniel S. Berman MD , Piotr J. Slomka PhD
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引用次数: 0
The Many Faces of Cardiac Involvement in Sarcoidosis 肉样瘤病心脏受累的多面性
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101995
Kelly McKay DO , Monica Ferrante DO , Robert Sibilia MD , Soumya Adhikari MD , Mahyar Pourriahi MD , Umama Gorsi MD , Kelly Laipply MD , Manisha Das MD
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引用次数: 0
The Safety of Stress Testing in Patients With Seizure Disorder 癫痫发作患者压力测试的安全性
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101988
Sana Hyder MBBS , Abeera Akram MBBS , Ina Lico DO , Emilio AbiRached M.D , Jeffrey Mather MS , Sean McMahon MD , Lane Duvall MD, FASNC
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引用次数: 0
Self-Reported Exercise Activity Predicts Hard Events Independently of Myocardial Flow Reserve and Chronotropic Response in Patients Undergoing PET-MPI 自我报告的运动活动预测硬事件,与 PET-MPI 患者的心肌血流储备和时变反应无关
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101959
Keiichiro Kuronuma MD , Alan Rozanski MD , Donghee Han MD , Rebekah Park MPH , Guadalupe Flores Tomasino MD , Sean W. Hayes MD , Louise Thomson MD , Damini Dey PhD , John D. Friedman MD , Piotr J. Slomka PhD, MASNC , Daniel S. Berman MD, MASNC
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引用次数: 0
Don’t Skip QC! Identifying Additional Hepatic Diagnostic Utility for MPI With 99mTc-Sestamibi SPECT 不要忽略质量控制!利用 99mTc-Sestamibi SPECT 确定 MPI 的其他肝脏诊断效用
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101974
Yetunde Adekemi Fatade MD, MPH, Hayan Jouni MD, John Bois MD
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引用次数: 0
Reduced Prognostic Value of Regadenoson Myocardial Perfusion Imaging in Liver Transplant Candidates in Comparison to Controls 与对照组相比,肝移植候选者的瑞格列酮心肌灌注成像的预后价值降低了
IF 3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-01 DOI: 10.1016/j.nuclcard.2024.101994
Aakanksha Sharma MD , Stephen Possick MD , Edward J. Miller MD, PhD, FASNC , Attila Feher MD, PhD
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引用次数: 0
期刊
Journal of Nuclear Cardiology
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