Journal of Nuclear Cardiology最新文献

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“Sail while the breeze blows” Navigating the tracer-dependence of absolute flow “乘风扬帆”利用对绝对气流的示踪依赖

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.1016/j.nuclcard.2025.102576

Jonathan B. Moody PhD, Alexis Poitrasson-Rivière PhD, Jennifer M. Renaud PhD

引用次数: 0

Head-to-head comparison of left ventricular volumes and ejection fraction by [13N]ammonia positron emission tomography, myocardial perfusion single-photon emission computed tomography with cadmium-zinc-telluride technology and cardiac magnetic resonance imaging [13N]氨正电子发射断层扫描、镉锌碲化技术心肌灌注单光子发射计算机断层扫描和心脏磁共振成像对左心室容积和射血分数的头对头比较

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI: 10.1016/j.nuclcard.2025.102542

Fredrik Hedeer MD, PhD , Sofia Kvernby PhD , Jenny Oddstig PhD , Shahnaz Akil Engblom PhD

Background

Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [¹³N]NH₃ PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic resonance (CMR) as reference.

Methods

A total of 74 patients with suspected chronic coronary syndrome, of which 27 patients were examined twice 6 months apart, were included. All performed CMR and [¹³N]NH₃ PET on the same day, and MPS with cadmium-zinc-telluride technology within 1.0 ± 1.8 days. LVEF, end-diastolic volume (EDV) and end-systolic volume (ESV) by [¹³N]NH₃ PET and MPS using standard clinical reconstruction parameters as well as reconstructions with altered filters, subsets, and iterations were compared to CMR (bias±standard deviation).

Results

Using standard clinical reconstruction parameters, both PET and MPS underestimated EDV (−58 ± 23 mL and −77 ± 22 mL, respectively) and ESV (−31 ± 19 mL and −29 ± 16 mL, respectively) compared to CMR. For LVEF, the bias was 5±6% and −3±7% for PET and MPS, respectively. The bias was slightly lowered for EDV by altering reconstruction parameters of PET (−56 ± 23 mL) and MPS (−76 ± 23 mL) images.

Conclusions

Left ventricular volumes by [¹³N]NH₃ PET and MPS are significantly underestimated compared to CMR when using standard clinical reconstruction parameters, whereas LVEF shows better agreement. Furthermore, there seems to be potential for improved accuracy of EDV, especially for [¹³N]NH₃ PET, when optimizing selected reconstruction parameters in the studied population.

背景：心脏正电子发射断层扫描（PET）和心肌灌注单光子发射计算机断层扫描（MPS）对左心室功能和尺寸的评估是心脏诊断成像的核心。本研究的目的是比较[13N]NH3 PET和MPS头对头，以心脏磁共振（CMR）为参考，评估左心室射血分数（LVEF）和容积。方法：74例疑似慢性冠状动脉综合征患者，其中27例间隔6个月复查2次。当日行CMR和[13N]NH3 PET，在1.0±1.8天内行镉锌碲化技术MPS。将[13N]NH3 PET和MPS的LVEF、舒张末期容积（EDV）和收缩末期容积（ESV）与CMR进行比较（偏差±SD），使用标准临床重建参数以及改变过滤器、子集和迭代重建。结果：使用标准临床重建参数，与CMR相比，PET和MPS均低估了EDV（分别为-58±23 ml和-77±22 ml）和ESV（分别为-31±19 ml和-29±16 ml）。对于LVEF， PET和MPS的偏差分别为5±6%和-3±7%。通过改变PET（-56±23 ml）和MPS（-76±23 ml）图像的重建参数，EDV的偏差略有降低。结论：与CMR相比，使用标准临床重建参数时，[13N]NH3 PET和MPS的左室容积明显被低估，而LVEF的一致性更好。此外，在优化研究人群中选择的重建参数时，似乎有可能提高EDV的准确性，特别是对于[13N]NH3 PET。

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引用次数: 0

Flow is the signal 流是信号

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.1016/j.nuclcard.2026.102624

Marcelo F. Di Carli MD, MASNC

引用次数: 0

Single- vs double-computed tomography scan for attenuation correction in single-photon emission computed tomography stress-rest myocardial perfusion studies: From polar maps similarity to clinical impact. SPECT应力休息心肌灌注研究中衰减校正的单次与双次计算机断层扫描：从极坐标图的相似性到临床影响。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-16 DOI: 10.1016/j.nuclcard.2025.102607

Łukasz Łabieniec, Krzysztof R Szymański, Andrzej Andrejczuk, Trifon J Spyridonidis, Kyriakos Filis, Dimitris J Apostolopoulos

Background: Standard procedure involves acquiring separate computed tomography (CT) scans during rest and stress for attenuation correction of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) which results in increased radiation dose for patients. The reduction of one of the CT scans can reduce radiation exposure. We investigated whether a single post-stress CT scan can be used for attenuation correction of both stress and rest MPI SPECT without affecting clinical interpretation.

Methods: A total of 106 consecutive patients underwent diagnostic MPI SPECT-CT with ^99mTc-tetrofosmin using CT-derived attenuation data at stress and rest. We created 106 post-rest perfusion pairs of polar maps reconstructed twice with rest and post-stress CT attenuation data. The similarity between these pairs of maps was assessed in three ways: (1) mathematically, (2) subjectively by 6 independent experienced nuclear medicine physicians, and (3) by categorical analysis of the summed perfusion score (SPS) to evaluate potential changes in clinical interpretation.

Results: The Bland-Altman analysis showed no differences in SPS between the pair of maps. The t-test showed no statistically significant differences between the scores of individual myocardial segments. Physicians rated the maps' similarity on average of 9.3 (±0.8) on a scale of 1 to 10, and a function was proposed to describe physicians' predicted responses based on compared pairs of maps. A categorical analysis revealed that approximately 30% of patients changed their SPS category when using 1CT instead of 2CT and that a small subset exhibited shifts large enough to potentially influence interpretation.

Conclusions: Using a single post-stress CT for attenuation correction of both stress and rest MPI SPECT appears feasible in most cases, but careful review is recommended. The method should be applied with caution, particularly when registration quality is suboptimal or when ischemia is clinically suspected.

背景：标准程序包括在休息和应激期间分别进行CT扫描，以校正SPECT心肌灌注成像（MPI）的衰减，这导致患者的辐射剂量增加。减少一次CT扫描可以减少辐射暴露。目的：我们研究了单次应力后CT扫描是否可以在不影响临床解释的情况下用于应力和休息MPI SPECT的衰减校正。方法：共有106例连续患者在压力和休息时使用ct获得的衰减数据，使用99mTc-tetrofosmin进行MPI SPECT-CT诊断。利用休息后和应力后CT衰减数据重建了106对休息后灌注极坐标图。通过三种方式评估这对图之间的相似性：(1)数学方法，(2)由6名独立的经验丰富的核医学医生主观评估，(3)通过灌注积分（SPS）的分类分析来评估临床解释的潜在变化。结果：Bland-Altman分析显示两组图的总灌注评分无差异。经t检验，各心肌节段评分差异无统计学意义。医生对这些地图的相似度的平均评价为9.3(±。8)在1到10的范围内，并提出了一个函数来描述医生基于比较对地图的预测反应。分类分析显示，当使用1CT而不是2CT时，大约30%的患者改变了他们的SPS类别，并且一小部分患者表现出足够大的变化，可能影响解释。结论：在大多数情况下，使用单一应力后CT进行应力和休息MPI SPECT的衰减校正似乎是可行的，但建议仔细审查。该方法应谨慎应用，特别是当登记质量不理想或临床怀疑缺血时。

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引用次数: 0

Assessment of coronary microvascular dysfunction in ischaemia with no obstructive coronary artery disease patients using ¹³N-ammonia-positron emission tomography: Lack of correlation with angiographic flow grades. 用13n -氨- pet评估INOCA患者冠状动脉微血管功能障碍：与血管造影血流等级缺乏相关性。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-15 DOI: 10.1016/j.nuclcard.2025.102596

Vinisha Gunasekaran, Harpreet Singh, Prashant Panda, Dinkar Bhasin, Yashpaul Sharma, Ashwani Sood, Bhagwant R Mittal

Background: Coronary microvascular dysfunction is implicated in ∼two-thirds of ischaemia with no obstructive coronary artery disease (INOCA) cases and is significant due to its association with a higher risk of major adverse cardiac events (MACE). While invasive techniques are the gold standard for diagnosing coronary microvascular dysfunction (CMD), positron emission tomography (PET) offers a noninvasive approach to quantifying myocardial blood flow (MBF) and detecting CMD. This study aimed to quantify myocardial flow reserve (MFR) using PET in INOCA patients to identify CMD and to correlate it with thrombolysis in myocardial infarction (TIMI) and TIMI myocardial perfusion grade (TMPG) angiographic flow grades.

Methods: Thirty INOCA patients with angiographic evidence of non-obstructive coronaries and slow flow were prospectively enrolled and underwent dynamic rest and stress cardiac ¹³N-NH₃ PET with MBF and MFR quantification. Patients with MFR values below 2.3 were classified as having CMD. Angiographic flow grades (TIMI and TMPG) were correlated with MFR and MBF.

Results: The mean global stress MBF and MFR for the study cohort were 2.54 ± 0.72 mL/minute/gm and 2.91 ± 0.81, respectively. No significant correlation was found between MFR and TIMI (r = -0.140, P = 0.108) or MFR and TMPG (r = -0.06, P = 0.446). Among the participants, 8 (27 %) had reduced global MFR less than 2.3 (mean: 1.80 ± 0.36), indicating CMD. The remaining 22 patients (73 %) had normal MFR values. Within the CMD group, 3 patients had functional CMD with elevated resting MBF, while 5 had classic CMD with blunted hyperaemic response to vasodilator stress.

Conclusions: PET is an excellent noninvasive modality for diagnosing CMD. Coronary slow flow in angiographically normal arteries does not correlate with ¹³N-NH₃ PET MFR values and is not a reliable marker for identifying CMD as indicated by the study's findings.

背景：冠状动脉微血管功能障碍与约2/3的INOCA病例有关，由于其与MACE的高风险相关，因此具有重要意义。虽然侵入性技术是诊断CMD的金标准，但PET提供了一种非侵入性方法来量化心肌血流量和检测CMD。本研究旨在利用PET量化INOCA患者的MFR，以确定CMD，并将其与TIMI和TMPG血管造影血流等级相关联。方法：前瞻性纳入30例具有非阻塞性冠状动脉和慢血流血管造影证据的INOCA患者，进行动态静息和应激心脏13N-NH3 PET，并进行MBF和MFR量化。MFR值低于2.3的患者被归类为CMD。血管造影血流等级（TIMI和TMPG）与MFR和MBF相关。结果：研究队列的平均整体应激MBF和MFR分别为2.54±0.72 ml/min/gm和2.91±0.81。MFR与TIMI （r=-0.140, p=0.108）、MFR与TMPG （r=-0.06, p=0.446）无显著相关性。在参与者中，8例（27%）总体MFR降低。结论：PET是诊断CMD的一种极好的非侵入性方法。研究结果表明，血管造影正常动脉的冠状动脉慢血流与13N-NH3 PET MFR值无关，也不是识别CMD的可靠标志。

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引用次数: 0

A case of early prosthetic valve endocarditis complicated with large pseudoaneurysm: The role of 18F-FDG PET/CT in initial and follow-up evaluation. 早期人工瓣膜心内膜炎合并大假性动脉瘤1例：18F-FDG PET/CT在初始和随访评估中的作用

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-11 DOI: 10.1016/j.nuclcard.2025.102594

Malay Mishra, Sameer Taywade, Rajesh Kumar, Surendra Patel

引用次数: 0

Regional myocardial uptake in routine oncologic ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography studies and coronary artery disease. 常规肿瘤18F-FDG PET/CT研究与冠状动脉疾病的局部心肌摄取

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-11 DOI: 10.1016/j.nuclcard.2025.102592

Didier Vilain, Nina Cobes, Astrid Girma, Raphael Amar, Marie Homo Seban, Stéphanie Russel, Hakim Ben Amer, Lea Turpin, Dominique Le Guludec

引用次数: 0

The effect of low-dose methotrexate on arterial inflammation in persons living with human immunodeficiency virus. A double-blind randomized placebo-controlled pilot trial. 低剂量甲氨蝶呤对人类免疫缺陷病毒感染者动脉炎症的影响。一项双盲随机安慰剂对照试验。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-11 DOI: 10.1016/j.nuclcard.2025.102591

Ahmed Tawakol, Heather Ribaudo, Ashley McKhann, Jamie W Bellinge, Hadil Zureigat, Zahi A Fayad, Michael M Lederman, Steven K Grinspoon, Daniel R Kuritzkes, James H Stein, Paul M Ridker, Judith S Currier, Priscilla Hsue

引用次数: 0

2025 ACC/AHA/ASE/ASNC/SCCT/SCMR advanced training statement on advanced cardiovascular imaging 2025 ACC/AHA/ASE/ASNC/SCCT/SCMR高级心血管影像学培训声明：ACC能力管理委员会报告

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-01 Epub Date: 2025-11-18 DOI: 10.1016/j.nuclcard.2025.102535

引用次数: 0

CME instructions: Incremental diagnostic value of AI-derived coronary artery calcium in18F-flurpiridaz PET Myocardial Perfusion Imaging CME说明：人工智能衍生冠状动脉钙在18f -氟吡唑PET心肌灌注成像中的增量诊断价值

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2025-12-01 Epub Date: 2025-12-20 DOI: 10.1016/j.nuclcard.2025.102563

引用次数: 0

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Journal of Nuclear Cardiology

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