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Effects of Low versus Intermediate Doses of Dexmedetomidine Infusion on Blood Loss, Hemodynamics, and Operative Time in Transsphenoidal Pituitary Tumor Removal: A Prospective Randomized Study 低剂量与中剂量右美托咪定输注对经蝶窦垂体瘤切除术出血量、血流动力学和手术时间的影响:一项前瞻性随机研究
Q4 ANESTHESIOLOGY Pub Date : 2023-02-06 DOI: 10.1055/s-0042-1758747
S. Muangman, M. Raksakietisak, P. Akavipat, P. Rushatamukayanunt, Sirinuttakul Akkaworakit, Natthaporn Romkespikun, Porntip Mahatnirunkul
Abstract Background  Dexmedetomidine, an alpha-2 agonist, has been widely used as an anesthetic adjunct for transsphenoidal pituitary resection. However, there is no consensus on the appropriate infusion dosage. This study aimed to compare the effects of low (0.2 mcg/kg/h) and intermediate (0.5 mcg/kg/h) dexmedetomidine infusions during anesthetic maintenance on blood loss, hemodynamics, and operating time. Methods  A randomized controlled trial involving two centers was conducted. Between December 2015 and November 2019, 80 patients (40 in each group) who underwent elective transsphenoidal pituitary tumor resection were recruited. Dexmedetomidine was administered to group I at a loading dose of 0.5 mcg / kg, followed by 0.2 mcg / kg / h, and to group II at the same loading dose, followed by 0.5 mcg / kg / h. Comparative analyses were performed using the Student's t -test, repeated-measures analysis of variance, and Mann–Whitney U test; p -values < 0.05 were considered statistically significant. Results  Eighty patients were analyzed. Patient demographics were comparable. The difference in intraoperative blood loss between both groups (320 [220–525] vs. 250 [100-487] mL, p  = 0.070) was not statistically significant. There were no differences in blood pressure or heart rate between the groups. In group II, the procedure took significantly less time (179 vs. 142 minutes, p  = 0.018), with more episodes of transient hypotension ( p  = 0.034). Conclusion  When maintaining anesthesia for transsphenoidal pituitary resection, dexmedetomidine infusions of 0.2 and 0.5 mcg / kg / h showed the same effect on blood loss and hemodynamics; however, significantly more episodes of transient hypotension and shorter operating times were noted with the latter.
摘要背景 右美托咪定是一种α-2激动剂,已被广泛用作经蝶垂体切除术的麻醉辅助药物。然而,对于合适的输液剂量还没有达成共识。本研究旨在比较麻醉维持期间低剂量(0.2 mcg/kg/h)和中等剂量(0.5 mcg/kg/小时)右美托咪定输注对失血、血液动力学和手术时间的影响。方法 进行了一项涉及两个中心的随机对照试验。2015年12月至2019年11月,招募了80名接受选择性经蝶垂体瘤切除术的患者(每组40人)。第一组给药的右美托咪定负荷剂量为0.5 mcg/kg,随后为0.2 mcg/kg/h,第二组给药相同负荷剂量,随后为0.5 mcg/kg/h.使用Student t检验、重复测量方差分析和Mann-Whitney U检验进行比较分析;p值 < 0.05被认为具有统计学意义。后果 对80名患者进行了分析。患者人口统计数据具有可比性。两组术中失血量的差异(320[220-525]与250[100-487]mL,p = 0.070)无统计学意义。两组之间的血压或心率没有差异。在第二组中,手术花费的时间明显更短(179对142 分钟,p = 0.018),出现更多的短暂性低血压(p = 0.034)。结论 当维持经蝶垂体切除术的麻醉时,输注0.2和0.5 mcg/kg/h的右美托咪定对失血和血流动力学表现出相同的效果;然而,后者的短暂性低血压发作次数明显增多,手术时间缩短。
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引用次数: 0
Successful Treatment of a COVID 19-Associated Multisystem Thrombotic Event in a Young Patient in a Neurocritical Care Unit 神经重症监护室一名年轻患者成功治疗新冠肺炎19相关多系统血栓事件
Q4 ANESTHESIOLOGY Pub Date : 2023-02-06 DOI: 10.1055/s-0042-1758489
Geetha Lakshminarasimhaiah, Ridhi Rao
Abstract This case report describes a young patient with no comorbidities, who presented with two systemic thrombotic events within 24 hours of admission. She presented with a right middle cerebral artery territory infarct and developed an inferior wall myocardial infarction soon after. The hypotension was refractory to inotropes and required emergency intra-aortic balloon pump insertion. She was evaluated for prothrombotic states and other causes of stroke in young. However, the workup for the same was negative. Coronavirus disease-2019 immunoglobulin G antibody titer and inflammatory markers were found to be extremely elevated, which suggested recent severe infection. This case report throws light on the multidisciplinary management of thrombotic events, most probably secondary to coronavirus infection.
摘要本病例报告描述了一名没有合并症的年轻患者,他在24小时内出现两次全身血栓事件 入院时间。她表现为右侧大脑中动脉区域梗死,不久后发展为下壁心肌梗死。低血压是不可逆的,需要紧急插入主动脉内球囊泵。她被评估了年轻人的血栓前状态和其他中风原因。然而,同样的检查结果是负面的。冠状病毒疾病-199免疫球蛋白G抗体滴度和炎症标志物被发现异常升高,这表明最近发生了严重感染。这份病例报告揭示了血栓事件的多学科管理,血栓事件很可能是继发于冠状病毒感染。
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引用次数: 0
Not All Postoperative Stridor in Infants Is Due to Endotracheal Tube-Induced Subglottic Edema 并非所有婴儿术后喘鸣都是由于气管内管引起的声门下水肿
Q4 ANESTHESIOLOGY Pub Date : 2023-02-06 DOI: 10.1055/s-0042-1758748
R. Mariappan, Rebecca A. Ninan, Krishnaprabhu Raju
Abstract A 6-month-old infant presented with clinicoradiological features of a shunt dysfunction. Magnetic resonance imaging brain showed multiple leptomeningeal cysts in the posterior fossa, with the largest in the right cerebellopontine (CP) angle cistern causing compression on the brain stem and fourth ventricle. There was gross hydrocephalus with the malpositioned shunt tube. He underwent shunt revision followed by right retromastoid craniectomy and decompression of the right CP angle cyst. Following extubation, he developed stridor that was diagnosed initially as subglottic edema and treated with humidified oxygen, systemic corticosteroids, and nebulized adrenaline. Failure to resolve the symptoms warranted a video laryngoscopy that revealed right vocal cord palsy (VCP), and he was reintubated. He was started on steroids and got extubated on a nasal continuous positive airway pressure and was gradually weaned off. Intraoperative handling of the vagus nerve while decompressing the cyst led to a right VCP, which was communicated later to the anesthesiologist. Neurological cause and association need to be considered as one of the differentials while managing postoperative stridor after posterior fossa surgery in an infant. Timely communication between the surgeon and anesthesiologist is paramount for reducing morbidity.
摘要:一名6个月大的婴儿出现分流功能障碍的临床病理特征。大脑磁共振成像显示后窝有多个软脑膜囊肿,其中最大的位于右桥小脑角池,导致脑干和第四脑室受压。有严重的脑积水和错位的分流管。他接受了分流翻修术,随后进行了右乳突后颅骨切除术和右CP角囊肿减压。拔管后,他出现了喘鸣,最初诊断为声门下水肿,并接受了加湿氧气、全身皮质类固醇和肾上腺素雾化治疗。未能解决症状需要进行视频喉镜检查,结果显示右声带麻痹(VCP),他被重新插管。他开始服用类固醇,在鼻腔持续正压通气下拔管,并逐渐断奶。在对囊肿进行减压的同时,对迷走神经进行术中处理,得到了右侧VCP,随后将其传达给麻醉师。在处理婴儿后颅窝手术后的喘鸣时,需要将神经系统原因和关联视为差异之一。外科医生和麻醉师之间的及时沟通对于降低发病率至关重要。
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引用次数: 1
Awake Craniotomy for Cerebral Abscess with Pulmonary Arteriovenous Malformation 清醒开颅治疗脑脓肿伴肺动静脉畸形
Q4 ANESTHESIOLOGY Pub Date : 2022-12-17 DOI: 10.1055/s-0042-1756432
Saloni Shah, A. Shetty, Dhairal Mehta
Abstract A cerebral abscess can be a life-threatening complication of pulmonary arteriovenous malformations (PAVM), thus posing significant morbidity if left untreated. We report a case of an incidental finding of a PAVM in a patient diagnosed with cerebral abscess. A 22-year-old male presented to the emergency department with acute onset right-sided weakness in both upper and lower limbs for 1 week. Magnetic resonance imaging showed a ring-enhancing lesion within the left parasagittal frontoparietal region s/o intracerebral abscess. High-resolution computed tomography was done as a protocol in patients posted for surgery due to coronavirus disease 2019 and coincidentally, it showed a single well-defined parenchymal nodule, 4 × 3.4 cm in the lateral basal segment of the left lower lobe. The knowledge of the pathophysiology of PAVM and expected complications during general anesthesia (GA) and positive pressure mechanical ventilation is essential. In such conditions, awake craniotomy under conscious sedation and scalp block may be considered as an alternative to GA.
摘要脑脓肿可能是肺动静脉畸形(PAVM)的一种危及生命的并发症,如果不及时治疗,会导致严重的发病率。我们报告一例诊断为脑脓肿的患者偶然发现PAVM。一名22岁男性因急性发作右上肢和下肢无力到急诊科就诊1周。磁共振成像显示左矢状额顶旁区有环形增强病变,无脑脓肿。高分辨率计算机断层扫描是在2019年因冠状病毒疾病而接受手术的患者中进行的,巧合的是,它显示了一个明确的实质结节,4 × 3.4 在左下叶的外侧基部段为cm。了解全身麻醉(GA)和正压机械通气期间PAVM的病理生理学和预期并发症是至关重要的。在这种情况下,清醒镇静和头皮阻滞下的清醒开颅术可能被认为是GA的替代方案。
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引用次数: 0
A Rare Case of Transesophageal Echocardiography Probe-Induced Tongue Ulcer 经食管超声心动图探头诱发舌溃疡的罕见病例
Q4 ANESTHESIOLOGY Pub Date : 2022-12-09 DOI: 10.1055/s-0042-1757169
Sanjay Surwade, R. Chelani, Manju Butani
Abstract Transesophageal echocardiography (TEE) is a commonly used diagnostic and monitoring modality in anesthetic practice. It is used in neurosurgery for monitoring cardiac function and detecting venous air embolism. TEE is a semi-invasive procedure and is considered to be reasonably safe with a few complications. During neurosurgical cases, access to the head end is limited and TEE can cause injury due to prolonged contact. These injuries can be noticed only at the conclusion of the surgery. We report a rare case of tongue ulcer caused due to the use of TEE in a sitting neurosurgical procedure with a complete resolution.
摘要经食管超声心动图(TEE)是麻醉实践中常用的诊断和监测方法。它在神经外科用于监测心脏功能和检测静脉空气栓塞。TEE是一种半侵入性手术,被认为是相当安全的,有一些并发症。在神经外科病例中,接触头端是有限的,TEE可能会因长时间接触而造成损伤。只有在手术结束时才能注意到这些损伤。我们报告了一例罕见的舌溃疡病例,该病例是由于在坐位神经外科手术中使用经食管超声心动图而引起的,且完全解决。
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引用次数: 0
A Rare Case of Severe Long COVID-19 in Patient with Amyotrophic Lateral Sclerosis 肌萎缩性侧索硬化症患者一例罕见的重症COVID-19
Q4 ANESTHESIOLOGY Pub Date : 2022-09-01 DOI: 10.1055/s-0042-1755366
P. Kodan, R. Aggarwal, Rakesh Kumar, Satyendra Nawal
There is growing interest on coronavirus disease 2019 (COVID-19)-associated neurological manifestations and the interplay of COVID-19 in patients with existing neurological illness.1 We wish to share our rare case of COVID-19-associated neurological manifestations in a patient with amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disease with very scarce information suggesting how COVID-19 affects patients with ALS.2,3 Case reports of COVID-19 in ALS are handful in literature and none of them highlights the acute deterioration in respiratory status with acute COVID-19 and the subsequent complications of long COVID-19. To the best of our knowledge, this is the first such reported case.
人们对2019冠状病毒病(新冠肺炎)相关的神经系统表现以及现有神经系统疾病患者中新冠肺炎的相互作用越来越感兴趣。1我们希望分享肌萎缩性脊髓侧索硬化症(ALS)患者中罕见的新冠肺炎相关神经系统表现。ALS是一种神经退行性疾病,很少有信息表明新冠肺炎如何影响ALS患者。2,3文献中关于ALS的新冠肺炎病例报告很少,没有一例报告强调急性新冠肺炎导致呼吸状态的急性恶化以及长期新冠肺炎的后续并发症。据我们所知,这是第一例此类病例。
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引用次数: 1
Radiation Safety for Anesthesiologists and Other Personnel on Simultaneous PET/MRI: Possible Radiation Exposure from Patients While Performing Prolonged Duration Scans 麻醉医师和其他人员同时进行PET/MRI的辐射安全:患者在进行长时间扫描时可能受到的辐射照射
Q4 ANESTHESIOLOGY Pub Date : 2022-09-01 DOI: 10.1055/s-0042-1750710
C. Nagaraj, R. Joshi, Dinesh G. Kumar, G. R, D. Chakrabarti, P. Singh, Sandhya Mangalore, Ramesh J. Venkatapura
Abstract This observational study was conducted owing to the challenges of the positron emission tomography/magnetic resonance imaging (PET/MRI) that requires longer duration scanning of radiopharmaceutical injected patient and added MRI environment. The aim of this study was to assess radiation dose at different distances from the patient and the radiation burden to anesthesiologist and other personnel in performing PET/MRI under general anesthesia or sedation. First, the pre- and postscan whole body radiation exposure (WBE) from the patient were obtained for 45 minutes ( n  = 109) after injection of the radiopharmaceutical. The WBE was obtained at specific distances from brain (10, 30, and 100 cm) and abdomen (10 and 30cm) of patients undergoing F18 fluorodeoxyglucose PET/MRI brain or whole body studies. Second, WBE of the anesthesiologist and other staff working was separately measured using pocket dosimeters during the whole procedure. In brain scans, the mean absorbed dose rates (ADR) of prescan (45 minutes) and postscan (45 minutes) were 44.4 and 31.1 μSv at 10 cm, 14.9 and 9.7μSv at 30 cm, and 3.5 and 2.8 μSv at 100 cm, respectively, from surface of head. Similarly, it was 54.8 and 30.3 μSv at 10 cm, 23 and 13.6μSv at 30 cm, respectively, from surface of abdomen. In WB scans, the mean ADR was higher than the brain scans. Anesthesiologist exposure overall was found to be 4.84 µSv/patient/scan (112 patients). The anesthesiologist receives a safe mean effective dose in PET/MRI scanning. With good training and adequate planning, it is possible to decrease the radiation exposure to all the concerned personnel including anesthesiologists.
摘要本观察性研究是由于正电子发射断层扫描/磁共振成像(PET/MRI)的挑战而进行的,这需要对注射放射性药物的患者进行更长时间的扫描,并增加MRI环境。本研究的目的是评估在全身麻醉或镇静下进行PET/MRI时,与患者不同距离的辐射剂量以及麻醉师和其他人员的辐射负担。首先,对45名患者进行扫描前和扫描后全身辐射暴露(WBE) 分钟(n = 109)。WBE是在距离大脑特定距离(10、30和100 cm)和腹部(10和30cm)。其次,在整个过程中,麻醉师和其他工作人员的WBE分别使用袖珍剂量计进行测量。在脑部扫描中,处方药(45 分钟)和后扫描(45 分钟)分别为44.4和31.1 30时分别为14.9和9.7μSv cm,100时为3.5和2.8μSv 距头部表面分别为厘米。同样,在10 cm、23和13.6μSv 距腹部表面分别为厘米。在WB扫描中,平均ADR高于脑部扫描。麻醉师的总体暴露量为4.84µSv/患者/扫描(112名患者)。麻醉师在PET/MRI扫描中接受安全平均有效剂量。通过良好的培训和充分的计划,可以减少包括麻醉师在内的所有相关人员的辐射暴露。
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引用次数: 0
Posttraumatic Tension Pneumocephalus Causing Atropine-Resistant Bradycardia 创伤后紧张性脑气引起阿托品抵抗性心动过缓
Q4 ANESTHESIOLOGY Pub Date : 2022-09-01 DOI: 10.1055/s-0042-1751091
Y. M. Gali, Lakshman K. Kommula, Subba R. Kesavarapu, S. Gurrala
Abstract Pneumocephalus is a serious complication following brain trauma. Tension pneumocephalus (TP) is entrapment of a large volume of air in the cranial vault causing mass effect on the brain parenchyma. It is the intracranial counterpart of tension pneumothorax and if neglected, can be life threatening. TP should be timely differentiated from benign pneumocephalus owing to its various nonspecific and lethal complications. Our patient is a 37-year-old male with a history of road traffic accident who presented to our hospital with headache and nasal discharge for the last two days. Computed tomography showed multiple skull fractures and extensive pneumocephalus. His preoperative heart rate was 38 beats per minute that was resistant to pharmacological interventions and required a temporary pacemaker for surgery. He underwent uneventful craniotomy for dura repair and was discharged home with no neurological deficit.
摘要肺炎是脑外伤后的一种严重并发症。张力性肺炎球菌(TP)是指大量空气滞留在颅顶,对脑实质造成肿块效应。它是张力性肺气肿的颅内对应物,如果被忽视,可能会危及生命。TP由于其各种非特异性和致命的并发症,应及时与良性肺头炎鉴别。我们的患者是一名37岁的男性,有道路交通事故史,在过去两天里因头痛和鼻腔分泌物来到我们医院。计算机断层扫描显示多处颅骨骨折和广泛的肺头畸形。他的术前心率为每分钟38次,对药物干预有抵抗力,需要临时起搏器进行手术。他顺利地接受了硬脑膜修复开颅手术,出院后没有神经系统缺陷。
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引用次数: 0
Transient Horner's Syndrome following Posterior Cervical Spine Instrumentation: A Postoperative Dilemma 颈椎后路固定术后的一过性Horner综合征:一个术后难题
Q4 ANESTHESIOLOGY Pub Date : 2022-09-01 DOI: 10.1055/s-0042-1757170
Balaji Vaithialingam, Mouleeswaran Sundaram, V. Bhadrinarayan
Horner ’ s syndrome is a rare phenomenon associated with a wide variety of medical and surgical conditions. Ipsilateral ptosis and miosis occur in Horner ’ s syndrome due to the sympathetic disruption at any point along the pathway from the posterolateral hypothalamus to the cervical sympathetic trunk. 1 It is awell-recognized but infrequententity following cervical spine instrumentation through the anterior approach with an incidence ranging from 0.02% to 3.8% during the anterior cervical discectomy and fusion (ACDF) proce-dure. 2,3 We report a rare case of transient Horner ’ ssyndrome following posterior cervical spine instrumentation for congenital atlantoaxial dislocation (AAD). A 13-year-old male patient presented with neck pain and weakness in all four limbs for the past 6 months. Neurologi-cal examination revealed a motor power of grade 3 in all four limbs with a normal pupillary size and reactivity. A diagnosis of reducible AAD was considered based on the dynamic computed tomographic (CT) imaging without radiological evidence of basilar invagination or Arnold Chiari malforma-tion. The patient was planned for C1-C2 fusion under general anesthesia in the prone position. After induction of anesthesia, the patient was placed in the prone position, the head was fi xed with the May fi eld clamp, and the eyes were
霍纳综合征是一种罕见的现象,与多种医学和外科条件有关。由于从下丘脑后外侧到颈交感干的通路上任何一点的交感神经中断,在霍纳综合征中发生同侧上睑下垂和瞳孔缩小。1在前路颈椎内固定手术(ACDF)过程中,发病率为0.02%至3.8%,这是公认但罕见的。2,3我们报告一例罕见的先天性寰枢脱位(AAD)后颈椎内固定术后短暂性Horner综合征。一名13岁男性患者在过去的6个月里表现为颈部疼痛和四肢无力。神经学检查显示四肢运动能力为3级,瞳孔大小和反应性正常。在没有基底内陷或Arnold Chiari畸形的放射学证据的情况下,基于动态计算机断层扫描(CT)诊断可减性AAD。患者计划在全身麻醉下俯卧位进行C1-C2融合。麻醉诱导后,将患者置于俯卧位,用May field钳固定头部,双眼
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引用次数: 0
Indocyanine Green Administration May Cause an Exaggerated Peripheral Oxygen Desaturation in the Presence of Liver Disease—An Underemphasized Observation 吲哚菁绿色给药可能导致肝病患者外周氧饱和度升高——一项未被重视的观察
Q4 ANESTHESIOLOGY Pub Date : 2022-09-01 DOI: 10.1055/s-0042-1760270
Mukilan Balasubramanian, Ankita Dey, Rajasekar Ramadurai, A. Kuberan
Microscope-integrated indocyanine green video angiography (ICG-VA) is used to assess the completeness of clipping and cerebral vascular fl ow during aneurysm surgery. 1 It is a more practical and less time-consuming alternative to intraoperative digital subtraction angiography (DSA). ICG has been reported to cause a decrease in peripheral oxygen saturation (SpO 2 ). 2 – 4 We report a 48-year-old male who presented with complaints of holocranial throbbing headache for 1 month without any history of seizures or focal neurological de fi cit. The patient was a known alcoholic for the past 20 years. Liver function test showed hyperbilirubinemia and elevat-ed serum transaminases. Noncontrast computed tomogra-phy brain revealed subarachnoid hemorrhage. The patient was found to have two aneurysms in the anterior cerebral circulation, one in the anterior communicating artery and one in the right M1 middle cerebral artery, on a DSA scan. He was scheduled for a craniotomy and clipping of both aneurysms. ICG (Aurogreen, Aurolab, Madurai, Tamil Nadu, India) at a dose of 0.25mg/kg
显微镜集成吲哚青绿视频血管造影术(ICG-VA)用于评估动脉瘤手术期间夹闭和脑血管流动的完整性。1它是一种比术中数字减影血管造影术(DSA)更实用、耗时更少的替代方案。ICG可引起外周血氧饱和度(SpO2)下降。2-4我们报告了一名48岁的男性,他主诉颅内悸动性头痛1个月,没有任何癫痫发作或局灶性神经疾病史。该患者在过去20年中是一名已知的酒鬼。肝功能检查显示高胆红素血症,血清转氨酶升高。大脑非集中性计算机断层扫描显示蛛网膜下腔出血。DSA扫描发现,患者大脑前循环中有两个动脉瘤,一个在前交通动脉,另一个在右侧M1大脑中动脉。他被安排进行开颅手术并夹闭两个动脉瘤。ICG(Aurogeren、Aurolab、Madurai、Tamil Nadu、India),剂量为0.25mg/kg
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引用次数: 1
期刊
Journal of Neuroanaesthesiology and Critical Care
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