Abstract The use of heat and moisture exchange filter (HMEF) has become a routine standard of care in general anesthesia (GA), more so, during the current COVID-19 pandemic times. However its routine use, especially in pediatric patients, has several issues. We report a case of increased dead space ventilation in a pediatric patient due to the presence of HMEF. Hypercapnia and its cause was instantly diagnosed with two capnography sampling lines placed at two ends of the HMEF.
{"title":"Effect of Heat and Moisture Exchange Filter on the Dead Space Ventilation in a Pediatric Patient","authors":"Mrunmayee Bhagwat, Rohini M. Surve, P. Patwardhan","doi":"10.1055/s-0041-1731602","DOIUrl":"https://doi.org/10.1055/s-0041-1731602","url":null,"abstract":"Abstract The use of heat and moisture exchange filter (HMEF) has become a routine standard of care in general anesthesia (GA), more so, during the current COVID-19 pandemic times. However its routine use, especially in pediatric patients, has several issues. We report a case of increased dead space ventilation in a pediatric patient due to the presence of HMEF. Hypercapnia and its cause was instantly diagnosed with two capnography sampling lines placed at two ends of the HMEF.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1731602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43853092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Electroconvulsive therapy (ECT) is one of the most successful treatment techniques employed in psychiatric practice. ECT is usually administered as a last resort to a patient who fails to respond to medical management or on an urgent basis as a life-saving procedure when immediate response is desired. It is performed under general anesthesia and is often associated with autonomic changes. All attempts should be made to minimize the resulting hemodynamic disturbances in all the patients using various pharmacological methods. Anesthesiologists providing anesthesia for ECT frequently encounter patients with diverse risk factors. Concurrent cardiovascular, neurological, respiratory, and endocrine disorders may require modification of anesthetic technique. It is ideal to optimize patients before ECT. In this review, the authors discuss the optimization, management, and modification of anesthesia care for patients with various cardiac, neurological, respiratory, and endocrine disorders presenting for ECT to improve the safety of the procedure. It is not infrequent that an anesthesiologist also plays an important role in inducing a seizure. Proconvulsants such as caffeine, adjuvants like opioids, hyperventilation, and appropriate choice of anesthetic agent for induction such as etomidate or ketamine can help. The use of BIS monitoring to guide the timing of electric stimulation is also elaborated in this review.
{"title":"Challenges during Electroconvulsive Therapy—A Review","authors":"S. Bansal, Rohini M. Surve, Rajeev Dayananda","doi":"10.1055/s-0041-1731627","DOIUrl":"https://doi.org/10.1055/s-0041-1731627","url":null,"abstract":"Electroconvulsive therapy (ECT) is one of the most successful treatment techniques employed in psychiatric practice. ECT is usually administered as a last resort to a patient who fails to respond to medical management or on an urgent basis as a life-saving procedure when immediate response is desired. It is performed under general anesthesia and is often associated with autonomic changes. All attempts should be made to minimize the resulting hemodynamic disturbances in all the patients using various pharmacological methods. Anesthesiologists providing anesthesia for ECT frequently encounter patients with diverse risk factors. Concurrent cardiovascular, neurological, respiratory, and endocrine disorders may require modification of anesthetic technique. It is ideal to optimize patients before ECT. In this review, the authors discuss the optimization, management, and modification of anesthesia care for patients with various cardiac, neurological, respiratory, and endocrine disorders presenting for ECT to improve the safety of the procedure. It is not infrequent that an anesthesiologist also plays an important role in inducing a seizure. Proconvulsants such as caffeine, adjuvants like opioids, hyperventilation, and appropriate choice of anesthetic agent for induction such as etomidate or ketamine can help. The use of BIS monitoring to guide the timing of electric stimulation is also elaborated in this review.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1731627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47777384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Mariappan, Sruthi Yalamanchili, Krishna Prabhu, Sharon Poldoss
1Department of Neuroanaesthesia, Christian Medical College, Vellore, Tamil Nadu, India 2Department of Anaesthesia, Christian Medical College, Vellore, Tamil Nadu, India 3Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India Address for correspondence Ramamani Mariappan, MD, Department of Neuroanaesthesia, Christian Medical College, Vellore 632004, Tamil Nadu, India (e-mail: ramamani@ cmcvellore.ac.in).
{"title":"The Effect of Dorsal Midbrain Compression by the Posterior third Ventricular Cyst on Frontal EEG Under Propofol Anesthesia","authors":"R. Mariappan, Sruthi Yalamanchili, Krishna Prabhu, Sharon Poldoss","doi":"10.1055/s-0041-1731147","DOIUrl":"https://doi.org/10.1055/s-0041-1731147","url":null,"abstract":"1Department of Neuroanaesthesia, Christian Medical College, Vellore, Tamil Nadu, India 2Department of Anaesthesia, Christian Medical College, Vellore, Tamil Nadu, India 3Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India Address for correspondence Ramamani Mariappan, MD, Department of Neuroanaesthesia, Christian Medical College, Vellore 632004, Tamil Nadu, India (e-mail: ramamani@ cmcvellore.ac.in).","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1731147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43085280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background There are recognized protocols that exist for management with minimal data regarding protocol adherence. We conducted a retrospective analysis of aneurysmal subarachnoid hemorrhage (aSAH) to determine whether the level of protocol adherence varied based on patient demographics or specific aspects of management. Materials and Methods All cases of aSAH admitted to a tertiary-level intensive care unit (ICU) from 2014 to 2016 were identified from the Australia and New Zealand Intensive Care Society Core Database as well as the clinical records system. ICU demographic and descriptive data for protocol adherence, were collected from admission to discharge up to 22 days, or until death whichever was earlier. Results A total of 58 cases of aSAH were registered; mean age was 56.7 years, 70.7% of patients were female, and mean length of stay was 12.6 days. World Federation of Neurosurgical Societies (WFNS) scale was documented more than Fisher grading. Of the 58 cases, 63.7% (37) underwent surgical clipping, with 83.7% (30) patients having this surgery within 48 hours. SBP/MAP were the most consistently recorded observations within protocol ranges, with adherence of 82.4% and 82.1%, respectively. Thirty-two percent of temperature measurements were outside of the normothermic range of 36.5 to 37.5°C with a mean adherence of 47.5% (standard deviation = ±0.24, median = 40). There was no correlation between adherence and patient, disease, or admission factors. Conclusion This study demonstrated that there was no association between variation in protocol adherence based on age, admission dates, or disease factors including WFNS grade and Fisher scale. Best protocol adherence protocol for the management of aSAH within the ICU was blood pressure control. Areas for improvement were documentation of the WFNS and Fisher grading, and temperature measurement and management.
{"title":"Protocol Adherence in the Intensive Care Unit for the Management of Adult Patients Admitted with Acute Aneurysmal Subarachnoid Hemorrhage","authors":"L. Taylor, A. Lane","doi":"10.1055/s-0040-1718504","DOIUrl":"https://doi.org/10.1055/s-0040-1718504","url":null,"abstract":"Abstract Background There are recognized protocols that exist for management with minimal data regarding protocol adherence. We conducted a retrospective analysis of aneurysmal subarachnoid hemorrhage (aSAH) to determine whether the level of protocol adherence varied based on patient demographics or specific aspects of management. Materials and Methods All cases of aSAH admitted to a tertiary-level intensive care unit (ICU) from 2014 to 2016 were identified from the Australia and New Zealand Intensive Care Society Core Database as well as the clinical records system. ICU demographic and descriptive data for protocol adherence, were collected from admission to discharge up to 22 days, or until death whichever was earlier. Results A total of 58 cases of aSAH were registered; mean age was 56.7 years, 70.7% of patients were female, and mean length of stay was 12.6 days. World Federation of Neurosurgical Societies (WFNS) scale was documented more than Fisher grading. Of the 58 cases, 63.7% (37) underwent surgical clipping, with 83.7% (30) patients having this surgery within 48 hours. SBP/MAP were the most consistently recorded observations within protocol ranges, with adherence of 82.4% and 82.1%, respectively. Thirty-two percent of temperature measurements were outside of the normothermic range of 36.5 to 37.5°C with a mean adherence of 47.5% (standard deviation = ±0.24, median = 40). There was no correlation between adherence and patient, disease, or admission factors. Conclusion This study demonstrated that there was no association between variation in protocol adherence based on age, admission dates, or disease factors including WFNS grade and Fisher scale. Best protocol adherence protocol for the management of aSAH within the ICU was blood pressure control. Areas for improvement were documentation of the WFNS and Fisher grading, and temperature measurement and management.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":"08 1","pages":"99 - 105"},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1718504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48912149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Trigeminal neuralgia (TN) is a chronic facial pain condition that affects one or more divisions of the trigeminal nerve (5th cranial nerve). It can be idiopathic, primary, or secondary. The cornerstone of the therapy has been antiepileptic medications, peripheral nerve blocks with various neurolytic agents, and surgical procedures. With the advent of newer technologies, minimally invasive neurolytic techniques like low-level laser therapy and ozone injection have revolutionized the management of TN. Novel drugs like vixotrigine and eslicarbazepine have been promising in reducing the frequency and severity of attacks. Inhaled carbon dioxide too has shown promising results in initial trials. Neuromodulation has given robust data in controlling neuralgic pain especially refractory to medical management. Pulsed radiofrequency has been used with increasing success and the side effects like dysesthesia and paresthesia are less. Cryotherapy, neural prolotherapy, and fiber knife techniques have helped us believe that TN can be controlled and cured. The need of the hour is to develop and explore newer modalities for trigeminal neuralgia treatment with minimum side effects. In this narrative review, we have tried to shed light into the newer modalities of treatment of TN along with new clinical classification for better disease recognition and management.
{"title":"Recent Advances in Trigeminal Neuralgia and Its Management: A Narrative Review","authors":"Sourav Burman, Ankur Khandelwal, A. Chaturvedi","doi":"10.1055/s-0041-1726152","DOIUrl":"https://doi.org/10.1055/s-0041-1726152","url":null,"abstract":"Abstract Trigeminal neuralgia (TN) is a chronic facial pain condition that affects one or more divisions of the trigeminal nerve (5th cranial nerve). It can be idiopathic, primary, or secondary. The cornerstone of the therapy has been antiepileptic medications, peripheral nerve blocks with various neurolytic agents, and surgical procedures. With the advent of newer technologies, minimally invasive neurolytic techniques like low-level laser therapy and ozone injection have revolutionized the management of TN. Novel drugs like vixotrigine and eslicarbazepine have been promising in reducing the frequency and severity of attacks. Inhaled carbon dioxide too has shown promising results in initial trials. Neuromodulation has given robust data in controlling neuralgic pain especially refractory to medical management. Pulsed radiofrequency has been used with increasing success and the side effects like dysesthesia and paresthesia are less. Cryotherapy, neural prolotherapy, and fiber knife techniques have helped us believe that TN can be controlled and cured. The need of the hour is to develop and explore newer modalities for trigeminal neuralgia treatment with minimum side effects. In this narrative review, we have tried to shed light into the newer modalities of treatment of TN along with new clinical classification for better disease recognition and management.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":"8 1","pages":"112 - 117"},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1726152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45197313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajit Bhardwaj, G. Satapathy, Arpit Garg, V. Chawla, K. Jangra
Background Paroxysmal sympathetic hyperactivity (PSH) is an understudied complication of traumatic brain injury (TBI). PSH usually presents with transient rise in sympathetic outflow, leading to increased blood pressure, heart rate, temperature, respiratory rate, sweating, and posturing activity. We retrospectively analyzed the incidence of PSH in TBI using PSH-assessment measure (PSH-AM) scale. Methods This single-center retrospective cohort study was conducted in traumatic head injury patients admitted in the intensive care unit from January 1, 2016 to December 31, 2019 in a tertiary care center. The data was collected from the hospital database after obtaining approval from the hospital ethics committee. Results A total of 287 patients (18–65 years of age) were admitted to intensive care unit (ICU) with TBI out of which 227 patients were analyzed who had ICU stay for more than 14 days. PSH was diagnosed in 70 (30.8%) patients. Mean age of PSH positive patients was 40 ± 18 and 49 ± 11 years for PSH negative patients (p < 0.001). The age group between 40 and 50 years had a higher incidence of PSH. The age and Glasgow coma score (GCS) were significantly associated with the occurrence of PSH. The GCS score demonstrated good accuracy for predicting the occurrence of PSH with AUC 0.83, 95% CI of 0.775 to 0.886, and a p-value of 0.001. Conclusion We observed that the incidence of PSH was 30.8% in the patients with TBI. Age and GCS were found to have a significant association for predicting the occurrence of PSH. The patients who developed PSH had a longer length of hospital stay in ICU.
{"title":"Incidence of Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury in a Tertiary Care ICU: A Retrospective Cohort Study","authors":"Ajit Bhardwaj, G. Satapathy, Arpit Garg, V. Chawla, K. Jangra","doi":"10.1055/S-0040-1721553","DOIUrl":"https://doi.org/10.1055/S-0040-1721553","url":null,"abstract":"\u0000Background Paroxysmal sympathetic hyperactivity (PSH) is an understudied complication of traumatic brain injury (TBI). PSH usually presents with transient rise in sympathetic outflow, leading to increased blood pressure, heart rate, temperature, respiratory rate, sweating, and posturing activity. We retrospectively analyzed the incidence of PSH in TBI using PSH-assessment measure (PSH-AM) scale.\u0000Methods This single-center retrospective cohort study was conducted in traumatic head injury patients admitted in the intensive care unit from January 1, 2016 to December 31, 2019 in a tertiary care center. The data was collected from the hospital database after obtaining approval from the hospital ethics committee.\u0000Results A total of 287 patients (18–65 years of age) were admitted to intensive care unit (ICU) with TBI out of which 227 patients were analyzed who had ICU stay for more than 14 days. PSH was diagnosed in 70 (30.8%) patients. Mean age of PSH positive patients was 40 ± 18 and 49 ± 11 years for PSH negative patients (p < 0.001). The age group between 40 and 50 years had a higher incidence of PSH. The age and Glasgow coma score (GCS) were significantly associated with the occurrence of PSH. The GCS score demonstrated good accuracy for predicting the occurrence of PSH with AUC 0.83, 95% CI of 0.775 to 0.886, and a p-value of 0.001.\u0000Conclusion We observed that the incidence of PSH was 30.8% in the patients with TBI. Age and GCS were found to have a significant association for predicting the occurrence of PSH. The patients who developed PSH had a longer length of hospital stay in ICU.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/S-0040-1721553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45150006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tariq Esmail, Sudhakar Subramaniam, L. Venkatraghavan
Abstract This review is a synopsis of selected articles from neuroscience, neuroanesthesia, and neurocritical care from the year 2020 (January–December 2020). The journals reviewed include anesthesia journals, critical care medicine journals, neurology and neurosurgical journals, as well as high-impact medical journals such as the Lancet, Journal of American Medical Association, New England Journal of Medicine, and Stroke. This summary of important articles will serve to update the knowledge of anesthesiologists and other perioperative physicians who provide care to neurosurgical and neurocritical care patients. In addition, some of the important narrative reviews that are of interest to neuroanesthesiologists are also listed.
{"title":"Year in Review: Synopsis of Selected Articles in Neuroanesthesia and Neurocritical Care from 2020","authors":"Tariq Esmail, Sudhakar Subramaniam, L. Venkatraghavan","doi":"10.1055/s-0041-1725223","DOIUrl":"https://doi.org/10.1055/s-0041-1725223","url":null,"abstract":"Abstract This review is a synopsis of selected articles from neuroscience, neuroanesthesia, and neurocritical care from the year 2020 (January–December 2020). The journals reviewed include anesthesia journals, critical care medicine journals, neurology and neurosurgical journals, as well as high-impact medical journals such as the Lancet, Journal of American Medical Association, New England Journal of Medicine, and Stroke. This summary of important articles will serve to update the knowledge of anesthesiologists and other perioperative physicians who provide care to neurosurgical and neurocritical care patients. In addition, some of the important narrative reviews that are of interest to neuroanesthesiologists are also listed.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":"08 1","pages":"012 - 019"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1725223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49388739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiation Exposure and the Neuroanesthesiologist","authors":"J. Pasternak","doi":"10.1055/S-0041-1725229","DOIUrl":"https://doi.org/10.1055/S-0041-1725229","url":null,"abstract":"","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":"08 1","pages":"001 - 002"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/S-0041-1725229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46185678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract With the advent of minimally invasive neurosurgical techniques and rapid innovations in the field of neurointervention, there has been a sharp rise in diagnostic and therapeutic modalities requiring radiation exposure. Neuroanesthesiologists are currently involved in various procedures inside as well as outside the operating room (OR) like intensive care units, interventional suites, and gamma knife units. The ambit expands from short-lasting diagnostic scans to lengthy therapeutic procedures performed under fluoroscopic guidance. Hence, a modern-day neuroanesthesiologist has to bear the brunt of the radiation exposure in both inside and outside the OR. However, obliviousness and nonadherence to the relevant radiation safety measures are still prevalent. Radiation protection and safety are topics that need to be discussed with new vigor in the light of current practice.
{"title":"Radiation Concerns for the Neuroanesthesiologists","authors":"Sourav Burman, A. Das, C. Mahajan, G. Rath","doi":"10.1055/s-0040-1715354","DOIUrl":"https://doi.org/10.1055/s-0040-1715354","url":null,"abstract":"Abstract With the advent of minimally invasive neurosurgical techniques and rapid innovations in the field of neurointervention, there has been a sharp rise in diagnostic and therapeutic modalities requiring radiation exposure. Neuroanesthesiologists are currently involved in various procedures inside as well as outside the operating room (OR) like intensive care units, interventional suites, and gamma knife units. The ambit expands from short-lasting diagnostic scans to lengthy therapeutic procedures performed under fluoroscopic guidance. Hence, a modern-day neuroanesthesiologist has to bear the brunt of the radiation exposure in both inside and outside the OR. However, obliviousness and nonadherence to the relevant radiation safety measures are still prevalent. Radiation protection and safety are topics that need to be discussed with new vigor in the light of current practice.","PeriodicalId":16574,"journal":{"name":"Journal of Neuroanaesthesiology and Critical Care","volume":"08 1","pages":"003 - 011"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41642702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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