Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_34_21
Thomas Linette, T. Gurumurthy
Background and Aims: Spinal anesthesia remains the preferred choice for cesarean deliveries, but hypotension is one of the common complications which may have detrimental effects on both the mother and fetus. In this study, we compared the efficacy and adverse effects of bolus doses of ephedrine hydrochloride and mephentermine sulfate administered intravenously to treat spinal-induced hypotension and the fetal outcomes through Apgar scores and umbilical cord blood gas analysis in the lower segment cesarean section. Material and Methods: In this prospective, randomized, double-blind study, 60 patients undergoing the lower segment cesarean section (LSCS) under spinal anesthesia were randomized into two groups of 30 each using computer-generated random numbers which were kept in an opaque envelope. Patients were pre-loaded with Ringer's lactate solution 10 ml/kg before the spinal anesthesia. Hypotension was defined as the fall in systolic blood pressure of less than or equal to 20% of the baseline or systolic blood pressure of less than 90 mmHg. Whenever hypotension occurred, patients in group E (ephedrine) received a bolus dose of ephedrine 6 mg intravenous and patients in group M (mephentermine) received a bolus dose of mephentermine 6 mg intravenous. Intra-operative recording included maternal hemodynamic parameters and the number of bolus doses of study drugs required to treat maternal hypotension and the adverse effects of study drugs. The Apgar score and umbilical cord blood gas values were recorded. Data were analyzed by analysis of variance test, Student's t-test, and Chi-square test. A P value of < 0.05 was considered as significant. Results: There was a statistically significant (p < 0.05) increase in systolic and mean arterial blood pressure at the second min and fourth min after administration of ephedrine in group E compared to mephentermine in group M. The systolic blood pressure at the second min in the ephedrine group was 114.3 ± 12.06, whereas in the mephentermine group, it was 106.10 ± 8.41 and was statistically significant (p < 0.05). At the fourth min, the systolic blood pressure in the ephedrine group was 115.03 ± 8.87, whereas in the mephentermine group, it was 108.46 ± 8.10 and was statistically significant (p < 0.05). There was a transient increase in heart rate immediately after administration of spinal anesthesia. The mean number of bolus doses of vasopressor consumption was 2.4 (14.4 mg) in the ephedrine group and 2 (12 mg) in the mephentermine group. The umbilical cord blood gas analysis and Apgar scores were similar in both the groups. Three patients (10%) developed bradycardia in the mephentermine group compared to the ephedrine group (0%). The incidence of nausea (13.3% vs 3.3%) and vomiting (10% vs 1%) was higher in the ephedrine group compared to the mephentermne group, and it was not statistically significant (p > 0.05). No significant differences were observed in the umbilical arterial blood pH and Apgar scores. Co
{"title":"Randomized trial of bolus ephedrine or mephentermine for maintenance of arterial pressure and fetal outcome during spinal anesthesia for the cesarean section","authors":"Thomas Linette, T. Gurumurthy","doi":"10.4103/joacc.joacc_34_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_34_21","url":null,"abstract":"Background and Aims: Spinal anesthesia remains the preferred choice for cesarean deliveries, but hypotension is one of the common complications which may have detrimental effects on both the mother and fetus. In this study, we compared the efficacy and adverse effects of bolus doses of ephedrine hydrochloride and mephentermine sulfate administered intravenously to treat spinal-induced hypotension and the fetal outcomes through Apgar scores and umbilical cord blood gas analysis in the lower segment cesarean section. Material and Methods: In this prospective, randomized, double-blind study, 60 patients undergoing the lower segment cesarean section (LSCS) under spinal anesthesia were randomized into two groups of 30 each using computer-generated random numbers which were kept in an opaque envelope. Patients were pre-loaded with Ringer's lactate solution 10 ml/kg before the spinal anesthesia. Hypotension was defined as the fall in systolic blood pressure of less than or equal to 20% of the baseline or systolic blood pressure of less than 90 mmHg. Whenever hypotension occurred, patients in group E (ephedrine) received a bolus dose of ephedrine 6 mg intravenous and patients in group M (mephentermine) received a bolus dose of mephentermine 6 mg intravenous. Intra-operative recording included maternal hemodynamic parameters and the number of bolus doses of study drugs required to treat maternal hypotension and the adverse effects of study drugs. The Apgar score and umbilical cord blood gas values were recorded. Data were analyzed by analysis of variance test, Student's t-test, and Chi-square test. A P value of < 0.05 was considered as significant. Results: There was a statistically significant (p < 0.05) increase in systolic and mean arterial blood pressure at the second min and fourth min after administration of ephedrine in group E compared to mephentermine in group M. The systolic blood pressure at the second min in the ephedrine group was 114.3 ± 12.06, whereas in the mephentermine group, it was 106.10 ± 8.41 and was statistically significant (p < 0.05). At the fourth min, the systolic blood pressure in the ephedrine group was 115.03 ± 8.87, whereas in the mephentermine group, it was 108.46 ± 8.10 and was statistically significant (p < 0.05). There was a transient increase in heart rate immediately after administration of spinal anesthesia. The mean number of bolus doses of vasopressor consumption was 2.4 (14.4 mg) in the ephedrine group and 2 (12 mg) in the mephentermine group. The umbilical cord blood gas analysis and Apgar scores were similar in both the groups. Three patients (10%) developed bradycardia in the mephentermine group compared to the ephedrine group (0%). The incidence of nausea (13.3% vs 3.3%) and vomiting (10% vs 1%) was higher in the ephedrine group compared to the mephentermne group, and it was not statistically significant (p > 0.05). No significant differences were observed in the umbilical arterial blood pH and Apgar scores. Co","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47593006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_114_21
P. Ahluwalia, B. Gupta
{"title":"Real-time assessment of esophageal occlusion by ultrasound-guided paralaryngeal pressure application in emergency LSCS—Time to change practices?","authors":"P. Ahluwalia, B. Gupta","doi":"10.4103/joacc.joacc_114_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_114_21","url":null,"abstract":"","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47167520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_109_21
S. Lye, Phui Sze Angie Au Yong
Parturients with achondroplasia post unique challenges to the anesthetist. Term achondroplastic parturients may have cephalopelvic disproportion resulting in lower section cesarean section (LSCS). Premature ossification of bones results in characteristic craniofacial abnormalities and is associated with atlantoaxial instability and macroglossia leading to a difficult airway. With pregnancy, airway edema and reduced functional reserve capacity further complicate intubation. Central neuraxial blockade (CNB) is challenging due to potential kyphoscoliosis, spinal stenosis, the unpredictable spread of local anesthetics in central neural space, and uncertainty of dose due to disproportionate spinal column to overall height. We present the challenges in a multiparous achondroplastic parturient coming in for emergency cesarean section done under combined spinal-epidural anesthesia technique.
{"title":"Combined spinal-epidural for emergency cesarean section in a multiparous parturient with achondroplasia","authors":"S. Lye, Phui Sze Angie Au Yong","doi":"10.4103/joacc.joacc_109_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_109_21","url":null,"abstract":"Parturients with achondroplasia post unique challenges to the anesthetist. Term achondroplastic parturients may have cephalopelvic disproportion resulting in lower section cesarean section (LSCS). Premature ossification of bones results in characteristic craniofacial abnormalities and is associated with atlantoaxial instability and macroglossia leading to a difficult airway. With pregnancy, airway edema and reduced functional reserve capacity further complicate intubation. Central neuraxial blockade (CNB) is challenging due to potential kyphoscoliosis, spinal stenosis, the unpredictable spread of local anesthetics in central neural space, and uncertainty of dose due to disproportionate spinal column to overall height. We present the challenges in a multiparous achondroplastic parturient coming in for emergency cesarean section done under combined spinal-epidural anesthesia technique.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42103997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Spinal anesthesia is the preferred technique for cesarean section, and a suitable level of spinal anesthesia is essential, which may be variable in every parturient. The aim of this study was to evaluate the correlation of abdominal circumference (AC), vertebral column length (VCL), hip shoulder width ratio (HSR), and vertebral column length (VCL)/Abdominal Circumference (AC)2 with the spread of spinal anesthesia in term parturient undergoing elective cesarean section. Methods: Two hundred term parturients undergoing elective cesarean section were enrolled in this prospective observational study. Spinal anesthesia was performed with 10 mg (2 ml) of 0.5% hyperbaric bupivacaine in L2-L3 or L3-L4 interspace using a 25 G Quincke needle. The cephalad spread (loss of pinprick discrimination) was assessed up to 30 minutes after intrathecal injection. Linear regression analysis was used to analyze the relationship between age, weight, height, body mass index (BMI), AC, VCL (C7-Sacral hiatus and C7-iliac crest), HSR, VCL/AC2, and the spread of spinal anesthesia. Results: The maximum sensory level showed a significant correlation with AC (P < 0.001), VCL [C7-SH and C7-IC] (P < 0.039 and P < 0.025) and VCL/AC2 (P < 0.001). Individually, hip width and shoulder width showed a significant correlation with cephalad spread of spinal anesthesia (P < 0.05); however, HSR had no significant correlation with the spread of anesthesia (P > 0.05). Conclusion: AC, VCL, and VCL/AC2 have a significant correlation with cephalad spread of spinal anesthesia when a fixed dose of hyperbaric bupivacaine is used in term parturients undergoing elective cesarean section, while HSR did not show any significant correlation.
{"title":"Effect of abdominal girth, vertebral column length, and hip/shoulder width ratio on the spread of spinal anesthesia in term parturients undergoing elective cesarean section: A prospective observational non-randomized study","authors":"A. Bhiwal, Heena Bhatt, Lalita Jeengar, Karuna Sharma, Aditi Baghel, Sunanda Gupta","doi":"10.4103/joacc.joacc_68_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_68_21","url":null,"abstract":"Background: Spinal anesthesia is the preferred technique for cesarean section, and a suitable level of spinal anesthesia is essential, which may be variable in every parturient. The aim of this study was to evaluate the correlation of abdominal circumference (AC), vertebral column length (VCL), hip shoulder width ratio (HSR), and vertebral column length (VCL)/Abdominal Circumference (AC)2 with the spread of spinal anesthesia in term parturient undergoing elective cesarean section. Methods: Two hundred term parturients undergoing elective cesarean section were enrolled in this prospective observational study. Spinal anesthesia was performed with 10 mg (2 ml) of 0.5% hyperbaric bupivacaine in L2-L3 or L3-L4 interspace using a 25 G Quincke needle. The cephalad spread (loss of pinprick discrimination) was assessed up to 30 minutes after intrathecal injection. Linear regression analysis was used to analyze the relationship between age, weight, height, body mass index (BMI), AC, VCL (C7-Sacral hiatus and C7-iliac crest), HSR, VCL/AC2, and the spread of spinal anesthesia. Results: The maximum sensory level showed a significant correlation with AC (P < 0.001), VCL [C7-SH and C7-IC] (P < 0.039 and P < 0.025) and VCL/AC2 (P < 0.001). Individually, hip width and shoulder width showed a significant correlation with cephalad spread of spinal anesthesia (P < 0.05); however, HSR had no significant correlation with the spread of anesthesia (P > 0.05). Conclusion: AC, VCL, and VCL/AC2 have a significant correlation with cephalad spread of spinal anesthesia when a fixed dose of hyperbaric bupivacaine is used in term parturients undergoing elective cesarean section, while HSR did not show any significant correlation.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48142405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_78_21
Ranju Singh, Rashi Sardana, Pooja Singh
Introduction: Kyphoscoliosis with pregnancy is a rare but serious disorder which often requires caesarean delivery. Both general and regional anaesthesia have been used in these cases but data regarding outcomes with spinal anaesthesia (SA) are limited. Methods: We conducted a retrospective study to identify patients with kyphoscoliosis undergoing caesarean delivery at a tertiary care hospital in India. Those parturients who received SA were compared with those receiving general anaesthesia (GA group) with respect to cardiorespiratory parameters, maternal outcomes and neonatal outcomes. Results: The GA group had significantly worse cardiorespiratory parameters including pulmonary function tests, right atrial pressures and cardiac ejection fraction as compared to SA group. All the GA group patients required mechanical ventilation while no patients in the SA group needed mechanical ventilation. Intraoperative hypotension was more common in the SA group. Neonatal outcomes were worse in the GA group with lower Apgar scores at 1 and 5 min and more nursery admissions than the SA group. No maternal or neonatal deaths occurred in either group. Conclusion: Kyphoscoliotic parturients scheduled for CD can be successfully managed with SA with good maternal and neonatal outcomes. GA may be reserved for severe kyphoscoliotic parturients with cardiorespiratory complications. The safety of SA in severe kyphoscoliosis requires further studies.
{"title":"Spinal anaesthesia in kyphoscoliotic parturients undergoing caesarean delivery – A retrospective study from a tertiary care centre in India","authors":"Ranju Singh, Rashi Sardana, Pooja Singh","doi":"10.4103/joacc.joacc_78_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_78_21","url":null,"abstract":"Introduction: Kyphoscoliosis with pregnancy is a rare but serious disorder which often requires caesarean delivery. Both general and regional anaesthesia have been used in these cases but data regarding outcomes with spinal anaesthesia (SA) are limited. Methods: We conducted a retrospective study to identify patients with kyphoscoliosis undergoing caesarean delivery at a tertiary care hospital in India. Those parturients who received SA were compared with those receiving general anaesthesia (GA group) with respect to cardiorespiratory parameters, maternal outcomes and neonatal outcomes. Results: The GA group had significantly worse cardiorespiratory parameters including pulmonary function tests, right atrial pressures and cardiac ejection fraction as compared to SA group. All the GA group patients required mechanical ventilation while no patients in the SA group needed mechanical ventilation. Intraoperative hypotension was more common in the SA group. Neonatal outcomes were worse in the GA group with lower Apgar scores at 1 and 5 min and more nursery admissions than the SA group. No maternal or neonatal deaths occurred in either group. Conclusion: Kyphoscoliotic parturients scheduled for CD can be successfully managed with SA with good maternal and neonatal outcomes. GA may be reserved for severe kyphoscoliotic parturients with cardiorespiratory complications. The safety of SA in severe kyphoscoliosis requires further studies.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49299876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_44_22
S. Pandya, K. Jain, A. Grewal, Ketan Parikh, Karuna Sharma, Anjeleena Gupta, S. Kasodekar, A. Parameswari, D. Gogoi, L. Raiger, Gonibeed Rao Ravindra, Sunanda Gupta, A. Trikha
Maternal cardiac arrest (MCA) requires a multidisciplinary team well versed in the cascade of steps involved during resuscitation. Historically, maternal outcomes were poor, primarily because cardiac arrest management in pregnant women was neither optimum nor standardized. However, current evidence has shown better maternal survival given the young age and reversible causes of death. There are specific interventions such as manual left uterine displacement (MLUD) for relief of aortocaval compression that, if not performed, may undermine the success of resuscitation. The team should simultaneously explore the etiology of MCA, which could be a combination of pregnancy-related causes and comorbid conditions. Resuscitative Hysterotomy or Resuscitative Uterine Interventions (RUI) should be considered if there is no return of spontaneous circulation following 4–5 min of cardiopulmonary resuscitation. Teamwork is critical to success in the high-stakes environment of MCA. This consensus statement was prepared by the experts after reviewing evidence-based literature on maternal resuscitation during MCA.
{"title":"The association of obstetric anesthesiologists, India – An expert committee consensus statement and recommendations for the management of maternal cardiac arrest","authors":"S. Pandya, K. Jain, A. Grewal, Ketan Parikh, Karuna Sharma, Anjeleena Gupta, S. Kasodekar, A. Parameswari, D. Gogoi, L. Raiger, Gonibeed Rao Ravindra, Sunanda Gupta, A. Trikha","doi":"10.4103/joacc.joacc_44_22","DOIUrl":"https://doi.org/10.4103/joacc.joacc_44_22","url":null,"abstract":"Maternal cardiac arrest (MCA) requires a multidisciplinary team well versed in the cascade of steps involved during resuscitation. Historically, maternal outcomes were poor, primarily because cardiac arrest management in pregnant women was neither optimum nor standardized. However, current evidence has shown better maternal survival given the young age and reversible causes of death. There are specific interventions such as manual left uterine displacement (MLUD) for relief of aortocaval compression that, if not performed, may undermine the success of resuscitation. The team should simultaneously explore the etiology of MCA, which could be a combination of pregnancy-related causes and comorbid conditions. Resuscitative Hysterotomy or Resuscitative Uterine Interventions (RUI) should be considered if there is no return of spontaneous circulation following 4–5 min of cardiopulmonary resuscitation. Teamwork is critical to success in the high-stakes environment of MCA. This consensus statement was prepared by the experts after reviewing evidence-based literature on maternal resuscitation during MCA.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47926524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_44_21
Wakhloo Renu, Bhagat Heena, Gandotra Megha, Suri Era
Background: Hypotension is a common side effect of spinal anesthesia for cesarean section with incidence of upto 71%. Various vasopressors are available for counteracting spinal hypotension each with different pharmacological profile. Norepinephrine is currently one of the feasible options for prophylaxis of spinal induced hypotension in patients undergoing cesarean section. Aims: To compare efficacy of phenylephrine and norepinephrine for reducing incidence of hypotension in patients undergoing cesarean section under spinal anesthesia and their effect on neonatal outcome. The primary outcome compared was incidence of hypotension (defined as fall in systolic blood pressure of >20% from the baseline value or a value <90 mmHg). The secondary outcomes noted were incidence of bradycardia, nausea, vomiting in the mother, and neonatal outcome. Methodology: A total of 80 singleton full term pregnant patients of American Society of Anesthesiology (ASA) grade II scheduled for elective cesarean section were randomly assigned to 2 groups of 40 patients each. Group P received phenylephrine 50 mcg and Group N received norepinephrine 10 mcg as intravenous bolus over 1 min immediately after the patient had been made supine after giving spinal anesthesia. The vital parameters, adverse effects, and neonatal outcome were assessed and analyzed statistically. Results: Intraoperatively, norepinephrine group had a significantly higher mean heart rate than phenylephrine group. Neonatal outcome was similar in both the groups with respect to appearance, pulse, grimace, activity, and respiration (Apgar) scores and umbilical arterial pH. Conclusions: In cesarean section under spinal anesthesia, norepinephrine efficacy in rescuing maternal hypotension is similar to that of phenylephrine without obvious maternal or neonatal adverse outcomes and with a lower incidence of bradycardia.
{"title":"Comparison of phenylephrine and norepinephrine for prevention of hypotension in patients undergoing cesarean section under spinal anesthesia – A randomized prospective study","authors":"Wakhloo Renu, Bhagat Heena, Gandotra Megha, Suri Era","doi":"10.4103/joacc.joacc_44_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_44_21","url":null,"abstract":"Background: Hypotension is a common side effect of spinal anesthesia for cesarean section with incidence of upto 71%. Various vasopressors are available for counteracting spinal hypotension each with different pharmacological profile. Norepinephrine is currently one of the feasible options for prophylaxis of spinal induced hypotension in patients undergoing cesarean section. Aims: To compare efficacy of phenylephrine and norepinephrine for reducing incidence of hypotension in patients undergoing cesarean section under spinal anesthesia and their effect on neonatal outcome. The primary outcome compared was incidence of hypotension (defined as fall in systolic blood pressure of >20% from the baseline value or a value <90 mmHg). The secondary outcomes noted were incidence of bradycardia, nausea, vomiting in the mother, and neonatal outcome. Methodology: A total of 80 singleton full term pregnant patients of American Society of Anesthesiology (ASA) grade II scheduled for elective cesarean section were randomly assigned to 2 groups of 40 patients each. Group P received phenylephrine 50 mcg and Group N received norepinephrine 10 mcg as intravenous bolus over 1 min immediately after the patient had been made supine after giving spinal anesthesia. The vital parameters, adverse effects, and neonatal outcome were assessed and analyzed statistically. Results: Intraoperatively, norepinephrine group had a significantly higher mean heart rate than phenylephrine group. Neonatal outcome was similar in both the groups with respect to appearance, pulse, grimace, activity, and respiration (Apgar) scores and umbilical arterial pH. Conclusions: In cesarean section under spinal anesthesia, norepinephrine efficacy in rescuing maternal hypotension is similar to that of phenylephrine without obvious maternal or neonatal adverse outcomes and with a lower incidence of bradycardia.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48817668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_100_21
Sajan Rahman, N. Puthenveettil, R. Jacob, G. Ravindran, S. Rajan, L. Kumar
Background and Aims: Labor epidural analgesia can be provided with local anesthetics alone or in combination with opioids. The aim of this study was to compare the duration of analgesia, onset time, and obstetric and fetal outcomes with three different concentrations of fentanyl. Methods: This double-blinded trial was conducted on 75 parturients who delivered with epidural analgesia. They were randomly assigned to three groups by the closed envelope technique. Groups A, B, and C received a bolus dose of 20 ml 0.1% ropivacaine with 1 μgml-1, 1.5 μgml-1, and 2 μgml-1 fentanyl, respectively, as an initial epidural dose. The duration, time to onset of analgesia, top-up doses required, hemodynamics, fetal-maternal outcomes, and complications were compared. Results: The mean duration of analgesia with the first epidural dose was 57.4 ± 14.207, 121.52 ± 33.951, and 165.08 ± 34.271 min in the A, B, and C groups, respectively, with a P of <.001. There was a higher duration of analgesia in the B group than in the A group (p-value <.001), in the C group than in the B group (p. 016), and in the C group than in the A group (p-value <.001). The onset of analgesia was faster in the C group than in the A and B groups (7.960 ± 1.695, 6.800 ± 1.607, and 5.960 ± 1.645 min in groups A, B, and C, respectively, with a P of. 001). The number of epidural boluses required was 3.480 ± 0.509, 2.640 ± 0.489, and 2.120 ± 0.331 in the A, B, and C groups, respectively. Conclusion: Labor epidural analgesia with a higher concentration of fentanyl produces a prolonged and faster onset of analgesia with fewer requirements for top-up boluses.
背景和目的：分娩硬膜外镇痛可以单独使用局部麻醉剂，也可以与阿片类药物联合使用。本研究的目的是比较三种不同浓度芬太尼的镇痛持续时间、起效时间以及产科和胎儿结局。方法：对75例硬膜外镇痛分娩产妇进行双盲试验。采用封闭包络法将他们随机分为三组。A、B和C组分别接受20 ml 0.1%罗哌卡因与1μgml-1、1.5μgml-2和2μgml-1芬太尼的单次给药，作为硬膜外初始剂量。比较镇痛持续时间、开始时间、所需补充剂量、血液动力学、胎儿-母体结局和并发症。结果：A、B和C组第一次硬膜外给药的平均镇痛持续时间分别为57.4±14.207、121.52±33.951和165.08±34.271分钟，P＜0.001。B组的镇痛持续时间高于a组（p值<.001），C组的镇痛时间高于B组（p值<0.016），以及C组的止痛持续时间高于a组（p值<.001）。C组的起效速度快于a组和B组（a、B和C组分别为7.960±1.695、6.800±1.607和5.960±1.645分钟，p值为.001）。A、B和C组所需硬膜外推注次数分别为3.480±0.509、2.640±0.489和2.120±0.331。结论：高浓度芬太尼分娩硬膜外镇痛可延长镇痛时间，加快镇痛速度，对补充药丸的需求更少。
{"title":"Labor epidural analgesia: Comparison of intermittent boluses of ropivacaine with three different concentrations of fentanyl – A randomized controlled trial","authors":"Sajan Rahman, N. Puthenveettil, R. Jacob, G. Ravindran, S. Rajan, L. Kumar","doi":"10.4103/joacc.joacc_100_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_100_21","url":null,"abstract":"Background and Aims: Labor epidural analgesia can be provided with local anesthetics alone or in combination with opioids. The aim of this study was to compare the duration of analgesia, onset time, and obstetric and fetal outcomes with three different concentrations of fentanyl. Methods: This double-blinded trial was conducted on 75 parturients who delivered with epidural analgesia. They were randomly assigned to three groups by the closed envelope technique. Groups A, B, and C received a bolus dose of 20 ml 0.1% ropivacaine with 1 μgml-1, 1.5 μgml-1, and 2 μgml-1 fentanyl, respectively, as an initial epidural dose. The duration, time to onset of analgesia, top-up doses required, hemodynamics, fetal-maternal outcomes, and complications were compared. Results: The mean duration of analgesia with the first epidural dose was 57.4 ± 14.207, 121.52 ± 33.951, and 165.08 ± 34.271 min in the A, B, and C groups, respectively, with a P of <.001. There was a higher duration of analgesia in the B group than in the A group (p-value <.001), in the C group than in the B group (p. 016), and in the C group than in the A group (p-value <.001). The onset of analgesia was faster in the C group than in the A and B groups (7.960 ± 1.695, 6.800 ± 1.607, and 5.960 ± 1.645 min in groups A, B, and C, respectively, with a P of. 001). The number of epidural boluses required was 3.480 ± 0.509, 2.640 ± 0.489, and 2.120 ± 0.331 in the A, B, and C groups, respectively. Conclusion: Labor epidural analgesia with a higher concentration of fentanyl produces a prolonged and faster onset of analgesia with fewer requirements for top-up boluses.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49151856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_47_22
V. Rewari, S. Hussain
{"title":"Patient safety in obstetric anesthesia","authors":"V. Rewari, S. Hussain","doi":"10.4103/joacc.joacc_47_22","DOIUrl":"https://doi.org/10.4103/joacc.joacc_47_22","url":null,"abstract":"","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49042102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/joacc.joacc_96_21
A. Ramalingam, Divya Devanathan, Rani Ponnusamy
The association of Parkinson's disease and pregnancy is very rare. We present a case of juvenile Parkinson's disease patient who underwent emergency caesarean section. The anaesthetic considerations and management are discussed.
{"title":"Anaesthetic management of a parturient with juvenile parkinson's disease in emergency – A case report","authors":"A. Ramalingam, Divya Devanathan, Rani Ponnusamy","doi":"10.4103/joacc.joacc_96_21","DOIUrl":"https://doi.org/10.4103/joacc.joacc_96_21","url":null,"abstract":"The association of Parkinson's disease and pregnancy is very rare. We present a case of juvenile Parkinson's disease patient who underwent emergency caesarean section. The anaesthetic considerations and management are discussed.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42713573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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