Background
The lack of understanding of postoperative pain patterns makes it challenging to adopt refined pain management for orthognathic patients.
Purpose
The purpose was to characterize pain trajectories for the first 5 days following orthognathic surgery and identify factors associated with the trajectories.
Study design, setting, and sample
This retrospective cohort study was conducted at Peking University Hospital of Stomatology and included individuals aged ≥18 years who underwent orthognathic surgery. Patients with neuropsychiatric disorders or missing postoperative pain data were excluded.
Predictor variables
The predictor variable was postoperative pain intensity, assessed daily from days 1 to 5 after surgery using numerical rating scale.
Main outcome variables
The outcome variable was pain trajectory, determined by group modeling of self-reported pain over the first 5 postoperative days.
Covariates
Covariates comprised demographic, psychological, surgical, and perioperative variables.
Analyses
Descriptive statistics were calculated for each variable. Group-based modeling determined and clustered pain trajectories, and logistic regression identified independent factors. A P value of < .05 was considered significant.
Results
The sample was composed of 371 subjects with a median age of 25 years [21 to 29] and 272 (73.3%) were female. We identified three pain trajectories, and there were 208 (56.1%), 111 (29.9%), 52 (14%) subjects in Trajectories 1, 2, and 3 groups, respectively. Trajectory 1 showed gradually decreasing pain. Trajectory 2 showed mild pain that decreased until day 3 and then increased slightly on days 4 to 5. Trajectory 3 showed moderate pain decreasing until day 3, increasing to moderate on day 4 and severe on day 5. Increased Pain Catastrophizing Scale score (adjusted odds ratio (OR), 1.033, 95% confidence interval (CI), 1.006 to 1.060, P = .015), American Society of Anesthesiologists classification I (adjusted OR, 2.593, 95% CI, 1.102 to 6.100, P = .029), increased remifentanil dose (adjusted OR, 1.301, 95% CI, 1.038 to 1.632, P = .023), and dezocine used in the analgesia pump (adjusted OR, 4.883, 95% CI, 1.953 to 12.209, P = .001) were associated with increased likelihood of Trajectory 3. Male had significantly lower risk of Trajectory 2 (adjusted OR, 0.424, 95% CI, 0.264 to 0.680, P < .001) and Trajectory 3 (adjusted OR, 0.489, 95% CI, 0.287 to 0.834, P = .009).
Conclusion
Distinct pain trajectories were exhibited after orthognathic surgery. It recommends patient-specific management across different trajectories.
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