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Itchy blisters on the fingers of a young boy 小男孩手指上的水泡发痒
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-09 DOI: 10.1111/jpc.16661
Sudip Kumar Ghosh, Arka Banerjee, Sharmistha Panja
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引用次数: 0
Two cases with undefined childhood interstitial lung disease: Can it be related to telomere variants? 两例未确定的儿童间质性肺病:是否与端粒变异有关?
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-09 DOI: 10.1111/jpc.16666
Halime Nayır Büyükşahin, Nagehan Emiralioğlu, Ebru Yalçın, H. Nursun Ozcan, Berna Oğuz, Gülen Eda Utine, Pelin Özlem Kiper, Beren Karaosmanoğlu, Diclehan Orhan, Sule Unal, İsmail Güzelkaş, Didem Alboğa, Deniz Doğru, Uğur Özçelik, Nural Kiper
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引用次数: 0
What is the utility of point-of-care ultrasound for suspected pulled elbow? A single-centre case series 护理点超声波对疑似肘关节牵拉有什么作用?单中心病例系列。
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-07 DOI: 10.1111/jpc.16659
David J McCreary, Nikhil Tambe, Niall Mullen

Radial head subluxation, known as pulled elbow or nursemaid's elbow, is a common presentation to the Paediatric Emergency Department (PED). Fifty per cent of children present following an unwitnessed injury or with an atypical history. Furthermore, examination can be difficult in an upset or frightened child meaning the precise location of the injury is not always easily identifiable. Many children receive upper limb x-rays unnecessarily and others undergo attempted reduction for suspected pulled elbow when a fracture is the cause of their pain.

Objective

To evaluate the ability of point-of-care ultrasound (POCUS) to correctly identify cases of suspected pulled elbow.

Methods

A retrospective review of patients aged 0–5 years presenting to the PED of our large District General Hospital from November 2020 to November 2022. We reviewed the electronic medical records of all patients presenting with a triage category of ‘elbow Injury’. We excluded patients presenting with obvious deformity, significant swelling and history of road traffic collision or other major trauma mechanism such as a fall from a height. POCUS was carried out by the authors according to pre-existing clinical protocols.

Results

Thirty-seven patients underwent POCUS. Twenty-nine had a typical history and all had a positive POCUS for pulled elbow. Of the remaining eight patients with an atypical history, three were found to have a positive POCUS compared to unaffected elbow. Five patients with an atypical history had negative POCUS findings and were diagnosed as soft tissue injuries after further assessment. All 32 with positive sonographic signs had a final diagnosis of pulled elbow, meaning the specificity was 100% (47.8–100) (P = 0.00003). The sensitivity was 100%.

Conclusion

Use of POCUS by appropriately trained clinicians, as an extension of a clinical examination, in this retrospective study reliably confirmed pulled elbow. This has the potential to reduce both unnecessary radiation as well as the time in the emergency department for the child and their carers.

桡骨头脱位,又称牵拉肘或护士肘,是儿科急诊室(PED)的常见病。50%的患儿是在未经目击的情况下受伤或病史不典型。此外,在患儿情绪不安或受到惊吓时,检查可能会比较困难,这意味着受伤的确切位置并不总是很容易辨认。许多儿童在不必要的情况下接受了上肢X光检查,还有一些儿童在怀疑肘关节牵拉的情况下接受了试图复位的手术,而骨折才是他们疼痛的原因:评估护理点超声(POCUS)正确识别疑似肘关节牵拉病例的能力:回顾性分析 2020 年 11 月至 2022 年 11 月期间在本地区大型综合医院 PED 就诊的 0-5 岁患者。我们查阅了分诊类别为 "肘部损伤 "的所有患者的电子病历。我们排除了有明显畸形、明显肿胀、道路交通碰撞或其他重大创伤病史(如高处坠落)的患者。POCUS由作者根据已有的临床方案进行:结果:37 名患者接受了 POCUS 检查。结果:37 名患者接受了 POCUS 检查,其中 29 人有典型病史,所有患者的肘关节牵拉 POCUS 检查结果均为阳性。在其余 8 位病史不典型的患者中,有 3 位与未受影响的肘部相比,POCUS 呈阳性。五名病史不典型的患者的 POCUS 结果为阴性,经进一步评估后被诊断为软组织损伤。所有 32 例声学征象阳性的患者最终诊断为肘关节牵拉,这意味着特异性为 100%(47.8-100)(P = 0.00003)。灵敏度为 100%:结论:在这项回顾性研究中,经过适当培训的临床医生使用 POCUS 作为临床检查的延伸,可以可靠地确诊肘关节牵拉。这有可能减少不必要的辐射,并缩短患儿及其护理人员在急诊科的就诊时间。
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引用次数: 0
Sleep problems and executive dysfunctions in pre-school children 学龄前儿童的睡眠问题和执行功能障碍。
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-07 DOI: 10.1111/jpc.16662
Hathaipohn Tangwijitsakul, Narueporn Likhitweerawong, Nonglak Boonchooduang, Weerasak Chonchaiya, Orawan Louthrenoo

Aim

The aim of the study was to examine the relationship between sleep problems and executive functions in pre-school children as reported by parents/caregivers.

Methods

This cross-sectional study of caregiver-child dyads was conducted in a public kindergarten school in Northern Thailand. Sleep problems were evaluated using the Children's Sleep Habits Questionnaire (CSHQ), whereas executive functions were assessed using the Behavioural Rating Inventory of Executive Function – pre-school version (BRIEF-P). T-scores greater than 65 of the BRIEF-P were defined as deficits in executive functions. Multiple linear regressions were performed to assess the association between the executive function components and the total CSHQ scores.

Results

Participants included 356 children, with a mean age of 5.04 (0.54) years. The total CSHQ scores of the executive dysfunction group were significantly higher than those of the group with executive functions below the cutoff (P < 0.001), which indicated more of sleep problems, including sleep-onset delay, night waking and daytime sleepiness. However, the duration of night sleep, night awake, afternoon nap and total sleep time reported by parents did not differ between the two groups. Weak positive correlations between the total CSHQ and subscale scores and the Global Executive Composite score of the BRIEF-P were noted. After adjusting for confounding variables, including child's age, gender, prematurity, maternal age and education, family income and media viewing time from the multiple linear regression analysis, the total CSHQ scores were significantly correlated with worse Global Executive Composite scores, which is the summary of five domains of executive functions (P < 0.001).

Conclusions

This study highlights the association between sleep problems and deficits in executive functions in healthy pre-school children. Health-care providers are encouraged to consistently advocate for proper sleep hygiene and practices to enhance executive functions in pre-schoolers.

目的:本研究旨在根据家长/照顾者的报告,探讨学龄前儿童的睡眠问题与执行功能之间的关系:这项横断面研究在泰国北部的一所公立幼儿园进行。睡眠问题通过儿童睡眠习惯问卷(CSHQ)进行评估,而执行功能则通过执行功能行为评定量表-学前版(BRIEF-P)进行评估。BRIEF-P的T分大于65分被定义为执行功能缺陷。为了评估执行功能成分与 CSHQ 总分之间的关联,我们进行了多元线性回归:研究对象包括 356 名儿童,平均年龄为 5.04 (0.54) 岁。执行功能障碍组的 CSHQ 总分明显高于执行功能低于临界值组的 CSHQ 总分(P 结论:该研究强调了儿童睡眠障碍与睡眠质量的关系:本研究强调了睡眠问题与健康学龄前儿童执行功能缺陷之间的关联。我们鼓励医疗保健提供者不断倡导正确的睡眠卫生和做法,以提高学龄前儿童的执行功能。
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引用次数: 0
Outcomes after childhood stroke in an inpatient paediatric rehabilitation unit: A retrospective study 儿童中风后在儿科康复住院部的回顾性治疗效果。
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-07 DOI: 10.1111/jpc.16658
Timothy McGowan, Janet Danielson, Frances Gehrmann, Nicola Hilton, Erin Lunn, Kim McLennan, Elizabeth Ryan, Penelope J Ireland

Aim

Childhood stroke has an estimated incidence of 2–13 per 100 000 children. Limited consensus exists regarding best practice recommendations for childhood stroke rehabilitation. A retrospective study completed at a tertiary institution identified potential associations between factors including type of stroke, functional presentation, muscle strength and length of stay (LOS).

Methods

A retrospective study of children post-stroke admitted 2014–2019 evaluated factors influencing outcome within inpatient rehabilitation. Exploratory analyses were completed to investigate relationships between variables including LOS, functional change, premorbid comorbidities and muscle strength.

Results

Data on 42 episodes of care (42 children: 18 males) following stroke were sourced from 2014 to 2019. Descriptive statistics were calculated for patient demographics, stroke characteristics, surgical treatment, premorbid comorbidities and muscle strength. Differences in WeeFIM scores between admission and discharge from the inpatient rehabilitation unit were tested using paired t tests. A higher number of children sustained ischaemic stroke (AIS, n = 24) when compared with haemorrhagic stroke (HS, n = 16). The average proportion of rehabilitation LOS to total hospital stay across all stroke types was 54.5%. Assessment of function demonstrated significant improvement between admission and discharge scores across all WeeFIM domains. Presence of comorbidities across stroke survivors was correlated with lower functional levels at discharge despite similar rehabilitation LOS.

Conclusion

Limited consensus exists guiding paediatric rehabilitation post-childhood stroke. This paper provides preliminary data on a cohort post-childhood stroke at a tertiary-level inpatient service. Paediatric stroke survivors showed significant functional improvements after inpatient rehabilitation, with the self-care domain showing greater improvements than mobility and cognition domains, respectively.

目的:儿童中风的发病率估计为每 10 万名儿童中有 2-13 名儿童中风。关于儿童中风康复的最佳实践建议,目前达成的共识有限。一项在三级医疗机构完成的回顾性研究确定了包括中风类型、功能表现、肌肉力量和住院时间(LOS)等因素之间的潜在关联:一项针对 2014-2019 年入院的脑卒中后儿童的回顾性研究评估了影响住院康复结果的因素。研究完成了探索性分析,以调查住院时间、功能变化、病前合并症和肌肉力量等变量之间的关系:收集了2014年至2019年42次中风后护理(42名儿童:18名男性)的数据。对患者人口统计学、中风特征、手术治疗、发病前合并症和肌肉力量进行了描述性统计。采用配对 t 检验法检验了入院和出院时在住院康复科的 WeeFIM 评分差异。与出血性中风(HS,16 人)相比,缺血性中风(AIS,24 人)患儿人数更多。在所有中风类型中,康复治疗时间占总住院时间的平均比例为 54.5%。功能评估显示,入院和出院时所有 WeeFIM 领域的评分均有明显改善。尽管康复时间相似,但中风幸存者的合并症与出院时功能水平较低有关:结论:指导儿童中风后康复的共识有限。本文提供了在一家三级医院住院治疗的儿童中风后群体的初步数据。儿童脑卒中幸存者在住院康复后的功能得到了显著改善,其中自理能力的改善程度分别高于行动能力和认知能力。
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引用次数: 0
Breastmilk use in preterm infants <29 weeks' gestational age in Australia, New Zealand and Singapore 澳大利亚、新西兰和新加坡胎龄小于 29 周的早产儿使用母乳的情况。
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-04 DOI: 10.1111/jpc.16656
Cathie Hilditch, Carmel T Collins, Alice Rumbold, Judith Gomersall, Philippa Middleton, Amy Keir, the N-3 fatty acids for improvement in Respiratory Outcomes (N3RO) Trial Investigators

Aims

To describe the prevalence of use of breastmilk and explore demographic characteristics and clinical outcomes associated with breastmilk provision in infants born <29 weeks' gestational age in Australia, New Zealand and Singapore.

Methods

This is a secondary analysis of data from a randomised controlled trial, which enrolled 1273 infants in 13 neonatal units across Australia, New Zealand and Singapore from 2012 to 2015. Infants were classified as formula-fed, donor milk-fed or mother's milk-fed at their first enteral feed and separately, at hospital discharge.

Results

The percentage of infants receiving mother's own milk differed between centres both at first feed (79% to 100%), and at hospital discharge (47.1% to 71.6%). Aboriginal, Torres Strait Islander and Southeast Asian heritage, drug use and smoking were associated with lower rates of fully breastmilk feeding at hospital discharge. There was no significant difference in growth outcomes, length of stay and feeding tolerance between feeding groups.

Conclusions

Achieving high breastmilk feeding rates at hospital discharge for all preterm infants born <29 weeks' gestational age at hospital discharge is possible; however, targeted support for mothers who are Indigenous, Southeast Asian and/or using recreational drugs and/or smoking and/or experiencing social disadvantage may be needed. A better understanding and shared knowledge of practice variations within neonatal units with high breastfeeding rates could improve breastmilk access and equity for preterm infants.

Australian New Zealand Clinical Trials Registry: ACTRN12612000503820.

目的:描述母乳喂养的普及率,并探讨与母乳喂养相关的婴儿人口特征和临床结果 方法:这是对随机对照试验数据的二次分析:这是一项随机对照试验数据的二次分析,该试验于 2012 年至 2015 年间在澳大利亚、新西兰和新加坡的 13 个新生儿科招募了 1273 名婴儿。婴儿在首次肠内喂养时被分为配方奶喂养、供体奶喂养或母乳喂养,出院时则分别进行分类:结果:各中心接受母乳喂养的婴儿比例在首次喂养时(79% 到 100%)和出院时(47.1% 到 71.6%)均有所不同。土著居民、托雷斯海峡岛民和东南亚血统、吸毒和吸烟与出院时完全母乳喂养率较低有关。不同喂养组在生长结果、住院时间和喂养耐受性方面没有明显差异:结论:所有早产儿出院时母乳喂养率均应达到较高水平:ACTRN12612000503820。
{"title":"Breastmilk use in preterm infants <29 weeks' gestational age in Australia, New Zealand and Singapore","authors":"Cathie Hilditch,&nbsp;Carmel T Collins,&nbsp;Alice Rumbold,&nbsp;Judith Gomersall,&nbsp;Philippa Middleton,&nbsp;Amy Keir,&nbsp;the N-3 fatty acids for improvement in Respiratory Outcomes (N3RO) Trial Investigators","doi":"10.1111/jpc.16656","DOIUrl":"10.1111/jpc.16656","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To describe the prevalence of use of breastmilk and explore demographic characteristics and clinical outcomes associated with breastmilk provision in infants born &lt;29 weeks' gestational age in Australia, New Zealand and Singapore.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a secondary analysis of data from a randomised controlled trial, which enrolled 1273 infants in 13 neonatal units across Australia, New Zealand and Singapore from 2012 to 2015. Infants were classified as formula-fed, donor milk-fed or mother's milk-fed at their first enteral feed and separately, at hospital discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The percentage of infants receiving mother's own milk differed between centres both at first feed (79% to 100%), and at hospital discharge (47.1% to 71.6%). Aboriginal, Torres Strait Islander and Southeast Asian heritage, drug use and smoking were associated with lower rates of fully breastmilk feeding at hospital discharge. There was no significant difference in growth outcomes, length of stay and feeding tolerance between feeding groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Achieving high breastmilk feeding rates at hospital discharge for all preterm infants born &lt;29 weeks' gestational age at hospital discharge is possible; however, targeted support for mothers who are Indigenous, Southeast Asian and/or using recreational drugs and/or smoking and/or experiencing social disadvantage may be needed. A better understanding and shared knowledge of practice variations within neonatal units with high breastfeeding rates could improve breastmilk access and equity for preterm infants.</p>\u0000 \u0000 <p>Australian New Zealand Clinical Trials Registry: ACTRN12612000503820.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":"60 11","pages":"684-690"},"PeriodicalIF":1.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpc.16656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-IL-5 treatments are a useful adjunct for treatment of chronic severe asthma 抗IL-5疗法是治疗慢性重症哮喘的有效辅助手段。
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-03 DOI: 10.1111/jpc.16639
Gillian M Nixon, David G McNamara, David S Armstrong
<p>https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010834.pub4/full?highlightAbstract=asthma%7Casthm</p><p>Farne HA, Wilson A, Milan S, Banchoff E, Yang F, Powell CVE. Anti-IL-5 therapies for asthma. Cochrane Database Syst. Rev. 2022; Issue 7: Art. No.: CD010834. DOI: 10.1002/14651858.CD010834.pub4. Accessed 23 December 2022.</p><p>The efficacy and safety of monoclonal anti-interleukin (IL)-5 antibodies (mepolizumab, reslizumab and benralizumab) for the treatment of chronic asthma, including both adults and children.<span><sup>1</sup></span> These treatments target IL-5 (mepolizumab and reslizumab) or the IL-5 receptor found on eosinophils and basophils (benralizumab), affecting the proliferation, maturation, activation, recruitment and survival of eosinophils.</p><p>Seventeen randomised controlled trials of anti-IL-5 therapy compared to placebo were included, six for mepolizumab (total of 2294 participants), five for reslizumab (2232 participants) and six for benralizumab (3888 participants). Seven included adult participants only, one (presented only in abstract form) included only children aged 6 to 17 years<span><sup>2</sup></span> and the remaining nine included adolescents aged over 12 years and adults. The majority of studies were considered to be at low risk of bias (15 studies), unclear in one study (the paediatric study presented only in abstract form)<span><sup>2</sup></span> and high in only one study of benralizumab that was terminated due to sponsor decision after randomising 13 participants. Using the GRADE system, evidence for all comparisons was considered to be high overall except for mepolizumab IV and reslizumab SC, which are not currently licensed delivery routes. The following summary is therefore limited to subcutaneous mepolizumab and benralizumab, the agents and routes currently funded for use in Australia and New Zealand.</p><p>Although children over 12 years were included in many of the studies in this review, results in adolescents were not reported separately and so a sub-group analysis could not be performed. This resulted in the review finding that there is insufficient data to reach a conclusion about efficacy and safety in this population. However, the single study exclusively in children and adolescents that was included in the review, with results only in abstract form, was consistent with the findings in adults.<span><sup>2</sup></span> That study has since been published and confirmed the efficacy of SC mepolizumab for 52 weeks in reducing asthma exacerbations requiring systemic corticosteroids (rate ratio 0.73; 95% CI 0.56–0.96; <i>P</i> = 0.027).<span><sup>5</sup></span> Treatment-emergent adverse events occurred in 42 (29%) of 146 participants in the mepolizumab group versus 16 (11%) of 144 participants in the placebo group.<span><sup>5</sup></span> Long-term safety of mepolizumab in 6–11 year old children with severe eosinophilic asthma has also been supported by an open label study (<i>n</i> =
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010834.pub4/full?highlightAbstract=asthma%7CasthmFarne HA、Wilson A、Milan S、Banchoff E、Yang F、Powell CVE。治疗哮喘的抗IL-5疗法。Cochrane Database Syst.Rev. 2022; Issue 7: Art.编号:CD010834.DOI: 10.1002/14651858.CD010834.pub4.单克隆抗白细胞介素(IL)-5抗体(mepolizumab、reslizumab和benralizumab)治疗慢性哮喘(包括成人和儿童)的疗效和安全性1。这些疗法针对IL-5(mepolizumab和reslizumab)或嗜酸性粒细胞和嗜碱性粒细胞上的IL-5受体(benralizumab),影响嗜酸性粒细胞的增殖、成熟、活化、招募和存活。纳入了17项抗IL-5疗法与安慰剂比较的随机对照试验,其中6项针对mepolizumab(共有2294名参与者),5项针对reslizumab(2232名参与者),6项针对benralizumab(3888名参与者)。其中 7 项研究仅包括成人参与者,1 项研究(仅以摘要形式提交)仅包括 6 至 17 岁的儿童2 ,其余 9 项研究包括 12 岁以上的青少年和成人。大多数研究被认为偏倚风险较低(15 项研究),1 项研究(仅以摘要形式呈现的儿科研究)的偏倚风险不明确2,仅有 1 项苯来珠单抗研究的偏倚风险较高,该研究在随机纳入 13 名参与者后因赞助商的决定而终止。根据 GRADE 系统,除了目前尚未获得给药途径许可的 mepolizumab IV 和 reslizumab SC 外,所有比较的证据总体上都被认为是高度证据。因此,以下总结仅限于皮下注射甲泼尼珠单抗和贝拉珠单抗,这两种药物和途径目前在澳大利亚和新西兰获得了使用许可。尽管本综述的许多研究中都包括了 12 岁以上的儿童,但没有单独报告青少年的结果,因此无法进行亚组分析。这导致审查结果认为,没有足够的数据来对这一人群的疗效和安全性下结论。不过,被纳入综述的一项专门针对儿童和青少年的研究(结果仅为摘要形式)与成人的研究结果一致。该研究已经发表,并证实了连续 52 周使用美泊利珠单抗(SC mepolizumab)对减少需要使用全身皮质类固醇的哮喘加重具有疗效(比率比 0.73;95% CI 0.56-0.96;P = 0.027)。一项开放标签研究(n = 30)也证实了麦泊利单抗在 6-11 岁重度嗜酸性粒细胞哮喘患儿中的长期安全性,该研究显示,与基线相比,麦泊利单抗未发生与治疗相关的严重不良事件,且哮喘加重和控制情况有所改善。8 过量使用皮质类固醇会增加患者感染、胃肠道事件、2 型糖尿病、骨折以及心血管和精神并发症的风险。生物制剂将在减少类固醇暴露方面发挥关键作用,尤其是在长期使用方面。9 患有嗜酸性粒细胞性哮喘的青少年,尽管吸入了至少中等剂量的皮质类固醇,但每年至少出现两次需要使用全身性皮质类固醇的病情加重,或哮喘控制问卷10 显示病情控制不佳(≥1.5),很可能从这些药物的治疗中获益。目前,澳大利亚药品福利计划(PBS)为 12 岁以上、在接受最佳哮喘治疗后病情仍未得到控制且患有嗜酸性粒细胞增多症的重症哮喘青少年皮下注射甲泼尼单抗(mepolizumab)和苯拉珠单抗(benralizumab)提供资助。嗜酸性粒细胞增多症的定义是:在过去 12 个月中,血液中嗜酸性粒细胞计数大于或等于每微升 300 个,或在接受口服皮质类固醇治疗期间大于或等于每微升 150 个。在新西兰,mepolizumab 和 benralizumab 可按 Pharmac 社区计划获得资助,除了每微升 500 个细胞的嗜酸性粒细胞计数要求较高外,其他要求类似。新西兰药品管理局的资助要求由呼吸科专家或免疫学家提出申请,而澳大利亚药品管理局则要求患者由呼吸科医生、临床免疫学家、过敏学家或在治疗严重哮喘患者方面经验丰富的全科医生进行治疗。
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引用次数: 0
Colour says it all 颜色说明一切
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-03 DOI: 10.1111/jpc.1_16593
Shruti Sharma, Nalini Bansal, Sunil Sharma
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引用次数: 0
A non-healing perianal ulceration 肛周溃疡无法愈合
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-03 DOI: 10.1111/jpc.1_16570
Chon-Wai J Chan, Samuel A Der Sarkissian, Li-Chuen F Wong, Ali Moghimi, Juliana Puppi

This patient has a variation of haemangioma known as infantile haemangioma with minimal or arrested growth presenting as a non-healing perianal ulceration. The diagnosis was confirmed by skin biopsy demonstrating strong diffuse positive GLUT1 immunostaining at the endothelial lining of the dermal vessels.1, 2 The arrested growth pattern explains the atypical appearance and the ulceration in the perianal area can possibly be explained by the fact that the early developing lesion is irritated by urine and faeces and traumatised by the necessary cleaning of the area.3-5 The perianal ulceration showed a rapid response with complete healing within 4 months of propranolol initiation (Fig. 1b). The morphology and location posed a diagnostic dilemma and required multidisciplinary evaluation to exclude alternate pathologies, including infantile inflammatory bowel disease, immunodeficiency disorders, a large segmental haemangioma and LUMBAR syndrome. This case highlights the importance of including infantile haemangioma among the differential diagnoses in neonates presenting with rapid onset perianal ulceration.

这名患者患有一种变异型血管瘤,被称为婴儿血管瘤,其生长微弱或停止,表现为肛周溃疡不愈合。皮肤活检显示真皮血管内皮弥漫性强阳性 GLUT1 免疫染色,从而确诊了该病。1, 2 生长停滞模式解释了该病的非典型外观,而肛周溃疡可能是由于早期病变受到尿液和粪便的刺激,并在必要的清洁过程中受到创伤。3-5 肛周溃疡反应迅速,在服用普萘洛尔后 4 个月内完全愈合(图 1b)。肛周溃疡的形态和位置造成了诊断上的难题,需要进行多学科评估以排除其他病变,包括婴儿炎症性肠病、免疫缺陷疾病、大片状血管瘤和 LUMBAR 综合征。本病例强调了在新生儿出现快速发作的肛周溃疡时,将婴儿血管瘤列入鉴别诊断的重要性。
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引用次数: 0
A nutritionally compromised infant with severe lactic acidosis and basal ganglia hyperintensities 一名营养不良的婴儿,患有严重的乳酸酸中毒和基底节过度密集症
IF 1.6 4区 医学 Q2 PEDIATRICS Pub Date : 2024-09-03 DOI: 10.1111/jpc.1_16597
Babar Gulzar, Nisar Ahmad Wani, Aaqib Zaffar Banday, Umar Amin Qureshi, Javeed Iqbal Bhat, Syed Tariq Ahmed Bukhari
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引用次数: 0
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Journal of paediatrics and child health
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