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Clinical characteristics of hospitalized patients with COVID-19: Results from multiple-center experience in Ardabil, Northwest of Iran 新冠肺炎住院患者的临床特征:来自伊朗西北部阿达比尔多中心经验的结果
Pub Date : 2023-02-12 DOI: 10.34172/jpd.2023.11192
S. Matin, Hassan Ghobadi, E. Safarzadeh, Leila Torabi Marjin, Masoomeh Dadkhah
Introduction: Since December 2019, coronavirus disease 2019 (COVID-19) has rapidly expanded to cause a worldwide pandemic. Objectives: We aimed to report the clinical characteristics of infected patients at the first wave in northwest of Iran. Patients and Methods: In this study, the epidemiological, demographic, clinical, and laboratory data of 1152 confirmed patients with COVID-19 who were admitted to two main hospitals at the first outbreak in northwest of Iran were collected and analyzed. Results: The most common clinical manifestations at onset were cough (65.8%), dyspnea (40.2%), myalgia (37.8%), and fever (63.4%), loss of appetite (47%), chest pain (38.6%), and headache (49.4%). While the less common were agitation (17.3%), vomiting (22.2%), diarrhea (16.7%), and nausea (24.3%). Laboratory data indicated significant correlation between lymphocyte counts with the severity of the disease based on O2 saturation. Conclusion: Overall, assessment the clinical data of COVID-19 patients play a crucial role in understanding the outbreak of novel viral pneumonia, which helps to identify high risk individuals with COVID-19.
导语:自2019年12月以来,2019冠状病毒病(COVID-19)迅速扩大,导致全球大流行。目的:报道伊朗西北部第一波感染患者的临床特征。患者和方法:本研究收集并分析了伊朗西北部首次暴发时两家主要医院收治的1152例COVID-19确诊患者的流行病学、人口学、临床和实验室资料。结果:发病时最常见的临床表现为咳嗽(65.8%)、呼吸困难(40.2%)、肌痛(37.8%)、发热(63.4%)、食欲不振(47%)、胸痛(38.6%)、头痛(49.4%)。较不常见的是躁动(17.3%)、呕吐(22.2%)、腹泻(16.7%)和恶心(24.3%)。实验室数据显示,基于氧饱和度的淋巴细胞计数与疾病严重程度之间存在显著相关性。结论:总体而言,评估COVID-19患者的临床资料对了解新型病毒性肺炎的爆发具有至关重要的作用,有助于识别COVID-19高危人群。
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引用次数: 0
An overview on acute kidney injury following COVID-19 COVID-19后急性肾损伤综述
Pub Date : 2023-02-09 DOI: 10.34172/jpd.2023.11179
Mohammad-Reza Hajian, M. Momenzadeh
COVID-19 is a newly emerging infectious disease which first described in December 2019 Wuhan, China. The disease rapidly spread through the world and after a short time of emerging, the World Health Organization (WHO) declared COVID-19 as a pandemic. Since, respiratory system is the main organ affected by COVID-19, the kidney could be involved as well. Given the importance of the kidney involvement in COVID-19, in this study we tried to evaluate and describe the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on kidney.
COVID-19是一种新型传染病,于2019年12月在中国武汉首次发现。新型冠状病毒感染症(COVID-19)在世界范围内迅速扩散,出现后不久,世界卫生组织(WHO)就宣布进入大流行状态。由于呼吸系统是新冠病毒感染的主要器官,因此肾脏也可能受到影响。鉴于COVID-19中肾脏受累的重要性,在本研究中,我们试图评估和描述严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)对肾脏的影响。
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引用次数: 0
Evaluating the effects of uric acid level reduction on serum vitamin D level in hemodialysis patients 评估降低尿酸水平对血液透析患者血清维生素D水平的影响
Pub Date : 2023-01-09 DOI: 10.34172/jpd.2023.11194
Negar Karevan, Saeed Mardani, Sara Karevan, H. Mardanparvar, Maryam Ghasemi, Mohammad-Seddigh Ghaffari
Introduction: The role of vitamin D in metabolism, bone-mineral regulation, and anti-oxidation effect has drawn researchers’ attention toward its exact role in hemodialysis. Objectives: In this study, the effect of uric acid level reduction on serum 25-hydroxy vitamin D levels in hemodialysis patients was assessed. Patients and Methods: This study is a triple-blind clinical trial conducted on 81 hemodialysis patients suffering from asymptomatic hyperuricemia. Serum uric acid levels were assessed at the start of the study. Then patients were divided randomly into two groups of intervention and control. The intervention group received 100 mg of allopurinol tablets daily for two months. The control group received placebo tablets for the same duration. At the end of the study, 25-hydroxyvitamin D and uric acid levels were assessed. Data were analyzed using SPSS software and chi-square, independent t test, Mann–Whitney U, and Spearman’s rank correlation tests. Results: In our study, two groups of control and intervention were similar in terms of patients’ demographic and hemodialysis characteristics. After the intervention, compared to the control group, the serum uric acid levels were significantly lower in the intervention group, while the level of 25-hydroxyvitamin D showed no significant difference between the two groups. Conclusion: In this study, no significant effect of uric acid lowering therapy with vitamin D elevation in hemodialysis patients was detected. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT2015041721803N1; https:// en.irct.ir/trial/18996, ethical code#IR.SKUMS.1395.231).
维生素D在代谢、骨矿物质调节和抗氧化中的作用引起了研究人员对其在血液透析中的确切作用的关注。目的:观察降低尿酸水平对血液透析患者血清25-羟基维生素D水平的影响。患者和方法:本研究是一项针对81例无症状高尿酸血症血液透析患者的三盲临床试验。在研究开始时评估血清尿酸水平。然后将患者随机分为干预组和对照组。干预组给予别嘌呤醇片100mg,每日服用2个月。对照组在相同的时间内服用安慰剂片。在研究结束时,评估了25-羟基维生素D和尿酸水平。数据分析采用SPSS软件、卡方检验、独立t检验、Mann-Whitney U检验和Spearman秩相关检验。结果:在我们的研究中,对照组和干预组在患者人口统计学和血液透析特征方面相似。干预后,与对照组相比,干预组血清尿酸水平明显降低,而25-羟基维生素D水平两组间无显著差异。结论:在本研究中,血液透析患者降尿酸加维生素D升高治疗无明显效果。试验注册:试验方案已获得伊朗临床试验注册中心批准(标识符:IRCT2015041721803N1;https:// en.irct。ir/trial/18996,道德准则# ir . skums .1395.231)。
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引用次数: 0
Possible cancer enhancement impact of parathyroid hormone excess 甲状旁腺激素过量可能对癌症的增强作用
Pub Date : 2023-01-07 DOI: 10.34172/jpd.2023.11195
M. Dehghani, Narges Esmaeili, M. Khosravian, H. Nasri
Implication for health policy/practice/research/medical education Various studies suggest an increased possibility of malignancy in primary hyperparathyroidism compared to the normal individuals which leads to increase mortality and morbidity; since, the location of the tumors is different. Several studies showing that the association between primary hyperparathyroidism and malignancy is more general in nature than emerge of a specific tumor, an issue which needs more investigations..
各种研究表明,与正常人相比,原发性甲状旁腺功能亢进症患者患恶性肿瘤的可能性增加,从而导致死亡率和发病率增加;因为,肿瘤的位置是不同的。一些研究表明原发性甲状旁腺功能亢进与恶性肿瘤之间的联系在本质上更为普遍,而不是特定肿瘤的出现,这一问题需要更多的研究。
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引用次数: 0
Goiter size changes as an indicator of response to treatment following selenium intake, and its correlation with goiter type 甲状腺肿大变化作为硒摄入后对治疗反应的指标,及其与甲状腺肿大类型的相关性
Pub Date : 2023-01-07 DOI: 10.34172/jpd.2023.11182
S. Kalbasi, H. Mardanparvar, A. Tajik, Danial Khazaeian, Ali Neyriz, F. Farsad, S. Ahmadi
Introduction: Goiter is a common problem in the world; however, it is more prevalent in countries with iodine deficiency. Goiter has different etiologies while one of them is Hashimoto’s thyroiditis. Selenium is a trace element that has different important effects in the body. It has also some effects in the thyroid. Objectives: This study aimed to evaluate the effect of selenium intake on goiter size and the correlation with goiter type. Patients and Methods: In prospective observational study, 20 patients with Hashimoto’s goiter and 40 patients with non-Hashimoto’s goiter were evaluated for thyroid sizes. The nodule sizes were else evaluated. After the first evaluation, daily selenium supplement (200 mg) was prescribed for all patients for six months. After this time, the sizes of goiter and nodules were measured again. Results: Results showed that the size of both goiter lobes in both Hashimoto’s and non-Hashimoto’s groups was significantly reduced before and after selenium intake (P<0.001). The reduction rate in left lobe size in patients with Hashimoto’s goiter was 50.73% and in nonHashimoto’s goiter patients was 20.89% (P<0.001). The reduction rate in right lobe size in patients with Hashimoto’s goiter was 53.37% and in non-Hashimoto’s goiter was 20.46 (P<0.001). Conclusion: We conclude that administration of selenium is effective in reducing the size of the goiter.
甲状腺肿是世界上常见的问题;然而,它在缺碘的国家更为普遍。甲状腺肿有不同的病因,其中之一是桥本甲状腺炎。硒是一种微量元素,对人体有不同的重要作用。它对甲状腺也有一些影响。目的:探讨硒摄入量对甲状腺肿大的影响及其与甲状腺肿大类型的关系。患者和方法:在一项前瞻性观察研究中,对20例桥本甲状腺肿患者和40例非桥本甲状腺肿患者的甲状腺大小进行评估。另外评估结节大小。在第一次评估后,所有患者每天补充硒(200毫克)6个月。在此之后,再次测量甲状腺肿和结节的大小。结果:结果显示,在摄入硒前后,桥本氏病组和非桥本氏病组的甲状腺肿大叶大小均显著减小(P<0.001)。桥本甲状腺肿患者左叶缩小率为50.73%,非桥本甲状腺肿患者为20.89% (P<0.001)。桥本甲状腺肿患者右肺叶缩小率为53.37%,非桥本甲状腺肿患者右肺叶缩小率为20.46% (P<0.001)。结论:硒对减小甲状腺肿大有一定的作用。
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引用次数: 0
Glomerulonephritis and impact of vitamin D; a short look to the recent evidence 肾小球肾炎及维生素D的影响我们来看看最近的证据
Pub Date : 2023-01-07 DOI: 10.34172/jpd.2023.11196
M. Dehghani, H. Nasri
Implication for health policy/practice/research/medical education Mechanistic impact of vitamin D therapy in glomerulopathies consists of preservation of morphological integrity of slit diaphragm, which leads to restoration of tight junction proteins. Vitamin D also avoids the loss of nephrin component of the glomerular basement membrane.
维生素D治疗肾小球疾病的机制影响包括保持狭缝隔膜的形态完整性,从而导致紧密连接蛋白的恢复。维生素D还可避免肾小球基底膜中肾素成分的损失。
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引用次数: 0
Zinc level alternation after phototherapy in neonates with hyperbilirubinemia 高胆红素血症新生儿光疗后锌水平的变化
Pub Date : 2023-01-04 DOI: 10.34172/jpd.2023.11193
Rakhshaneh Goodarzi, S. Saadat, Fatemeh Janbozorgi, Behnaz Darban
Introduction: One of the old treatment methods for unconjugated hyperbilirubinemia in neonates is blood exchange transfusion, which is expensive, possibly high-risk, and time-consuming. Today phototherapy as a novel method can be a good alternative. Objectives: This study aimed to evaluate the zinc level alternation after phototherapy in neonates with hyperbilirubinemia. Patients and Methods: A descriptive-analytical study was conducted on 85 infants with hyperbilirubinemia who underwent phototherapy referred to the pediatric hospital in Bandar- Abbas, Iran from 2017 to 2018. Healthy infants over two days with idiopathic jaundice with a gestational age greater than 34 weeks and only breast-feed were enrolled. Serum zinc levels were measured before and after phototherapy, and their changes were evaluated. Results: Out of 85 neonates, 42 (49.4%) were male and 43 (50.6%) were female with a mean gestational age of 37.83 ± 0.58 weeks and admission age of 4.15 ± 1.70 days. Zinc level before phototherapy was 84.98 ± 52.06 (μg/dL) and after phototherapy was 234.41 ± 280.98. The difference between serum zinc levels before and after the phototherapy was significant therefore, the zinc level significantly increased after the phototherapy. Conclusion: Results showed that phototherapy increases serum zinc levels, which can cause zinc toxicity. It is wise to measure serum zinc levels before and during phototherapy and seek the appropriate medical care.
新生儿非偶联性高胆红素血症的旧治疗方法之一是换血,这是昂贵的,可能存在高风险,耗时。今天,光疗作为一种新颖的治疗方法是一个很好的选择。目的:研究高胆红素血症新生儿光疗后锌水平的变化。患者和方法:对2017年至2018年在伊朗班达尔阿巴斯儿科医院接受光疗的85名高胆红素血症婴儿进行了描述性分析研究。患有特发性黄疸且孕龄大于34周且仅母乳喂养超过2天的健康婴儿被纳入研究。测定光疗前后血清锌水平,并评价其变化。结果:85例新生儿中,男42例(49.4%),女43例(50.6%),平均胎龄37.83±0.58周,入院年龄4.15±1.70天。光疗前锌含量为84.98±52.06 (μg/dL),光疗后为234.41±280.98。光疗前后血清锌水平差异显著,光疗后血清锌水平明显升高。结论:光疗可使血清锌水平升高,引起锌中毒。在光疗之前和期间测量血清锌水平并寻求适当的医疗护理是明智的。
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引用次数: 0
Thyroid status and severity or mortality of COVID-19 甲状腺状况与COVID-19的严重程度或死亡率
Pub Date : 2022-11-03 DOI: 10.34172/jpd.2022.11187
A. Hassanzadeh Rad, Amirhossein Fakhre Yaseri
Implication for health policy/practice/research/medical education The non-thyroidal illness syndrome is characterized by low triiodothyronine in people with normal thyroid status, commonly occurring in seriously ill patients or individuals with malnutrition. Several studies showed people with severe COVID-19 had much lower free triiodothyronine levels than the patients who had less sever COVID-19. Therefore, free serum triiodothyronine may become a predictor of the severity of COVID-19 and an indicator for its management.
非甲状腺疾病综合征的特点是甲状腺功能正常的人群中三碘甲状腺原氨酸水平低,常见于重症患者或营养不良患者。几项研究表明,COVID-19严重患者的游离三碘甲状腺原氨酸水平远低于COVID-19不严重患者。因此,游离血清三碘甲状腺原氨酸可能成为COVID-19严重程度的预测指标和其管理的指标。
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引用次数: 1
Lithium therapy and parathyroid gland interaction 锂治疗与甲状旁腺的相互作用
Pub Date : 2022-11-01 DOI: 10.34172/jpd.2022.11178
R. Tolouian, A. Baradaran
Lithium is a trace element that has been commonly used in treating bipolar affective disorder for years. Lithium therapy causes renal failure, several endocrine and metabolic abnormalities, such nephrogenic diabetes insipidus, thyroid abnormalities, and hypercalcemia. Early detection of lithium-related hypercalcemia and primary hyperparathyroidism will ameliorate patients’ situations. Besides, regular serum calcium and parathormone assessment in individuals on lithium therapy is strongly recommended.
锂是一种微量元素,多年来一直普遍用于治疗双相情感障碍。锂治疗可导致肾功能衰竭、多种内分泌和代谢异常,如肾源性尿崩症、甲状腺异常和高钙血症。早期发现锂相关的高钙血症和原发性甲状旁腺功能亢进将改善患者的情况。此外,强烈建议在接受锂治疗的个体中定期进行血清钙和甲状旁激素的评估。
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引用次数: 0
COVID-19 and red cell distribution width COVID-19和红细胞分布宽度
Pub Date : 2022-11-01 DOI: 10.34172/jpd.2022.11184
A. Baradaran, Narges Esmaeili
Red cell distribution width is an easy method to assess of erythrocyte size alteration, which can be conducted for the diagnosis of various hematological disorders like anemia related to iron deficiency and bone marrow disease. This marker could be a prognostic predictor of severe cases of COVID-19 too.
红细胞分布宽度是评估红细胞大小改变的简便方法,可用于各种血液学疾病的诊断,如缺铁性贫血、骨髓疾病等。这一标志物也可能是COVID-19严重病例的预后预测指标。
{"title":"COVID-19 and red cell distribution width","authors":"A. Baradaran, Narges Esmaeili","doi":"10.34172/jpd.2022.11184","DOIUrl":"https://doi.org/10.34172/jpd.2022.11184","url":null,"abstract":"Red cell distribution width is an easy method to assess of erythrocyte size alteration, which can be conducted for the diagnosis of various hematological disorders like anemia related to iron deficiency and bone marrow disease. This marker could be a prognostic predictor of severe cases of COVID-19 too.","PeriodicalId":16657,"journal":{"name":"Journal of Parathyroid Disease","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74246986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Parathyroid Disease
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