Background and Objectives: Religious orientation is one of the factors influencing behavior and cognition.Considering the necessity of recognizing the factors affecting students' religious orientation, the present study has investigated the relationship between religious orientation and emotional intelligence components in students of Shahid Beheshti University of Medical Sciences. Materials and Methods : The design of this research is descriptive-correlational. The statistical population consisted of all medical students of Shahid Beheshti University of Medical Sciences. In this study, a sample size of 63 students were studying (girls = 32, boys = 31 ), who were selected by random sampling. In the present study, the confidentiality and all ethical principles are observed. Also, the authors of the article have not reported any conflicts of interest. The tool for collecting information was Alport Religious Orientation Questionnaire and Bar-An Emotional Intelligence Questionnaire. Data were analyzed using SPSS software and descriptive statistical methods (mean and standard deviation) and regression analysis. Result : The findings of this study indicate that external and internal religious orientation has a significant effect on the components of emotional intelligence at 5% level.The value of this coefficient in this research is 0.19, in fact, students' religious orientation has 19% ability to predict the components of emotional intelligence. Conclusion : The results of this study showed that religious orientation can play an effective role in predicting students' emotional intelligence.Students with a high religious orientation are flexible, tolerant of stress and high happiness. They have a high responsibility in social situations.
{"title":"The study of relationship between religious orientations with emotional intelligence components Among Students of Shahid Beheshti University of Medical Sciences","authors":"Reza Tajabadi","doi":"10.22037/JPS.V8I4.18364","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.18364","url":null,"abstract":"Background and Objectives: Religious orientation is one of the factors influencing behavior and cognition.Considering the necessity of recognizing the factors affecting students' religious orientation, the present study has investigated the relationship between religious orientation and emotional intelligence components in students of Shahid Beheshti University of Medical Sciences. Materials and Methods : The design of this research is descriptive-correlational. The statistical population consisted of all medical students of Shahid Beheshti University of Medical Sciences. In this study, a sample size of 63 students were studying (girls = 32, boys = 31 ), who were selected by random sampling. In the present study, the confidentiality and all ethical principles are observed. Also, the authors of the article have not reported any conflicts of interest. The tool for collecting information was Alport Religious Orientation Questionnaire and Bar-An Emotional Intelligence Questionnaire. Data were analyzed using SPSS software and descriptive statistical methods (mean and standard deviation) and regression analysis. Result : The findings of this study indicate that external and internal religious orientation has a significant effect on the components of emotional intelligence at 5% level.The value of this coefficient in this research is 0.19, in fact, students' religious orientation has 19% ability to predict the components of emotional intelligence. Conclusion : The results of this study showed that religious orientation can play an effective role in predicting students' emotional intelligence.Students with a high religious orientation are flexible, tolerant of stress and high happiness. They have a high responsibility in social situations.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84342362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to examine the effect of shift work on overweight and obesity, hypercholesterolemia and GHQ score (GHQ-28) as an indicator of psychological well-being in subjects working in petrochemical industry sited in Mahshahr, west of Iran. In This longitudinal study, population consisted of 2493 (1321 day workers and 1171 shift workers) whose mean ages were 46.18 years for day workers and 45.53 years for shift workers, during a four years period (from 2008 to 2011). All workers were investigated by Persian version of General Health Questionnaire-28 (GHQ-28) as screen tool. The serum cholesterol, height and weight were measured with definitions of hypercholesterolemia as serum total cholesterol 220 mg/dl, overweight and obesity as body mass index (BMI) 25 kg/m 2 . A conditional joint random effects models approach was applied to explore the effect of shift working on multivariate responses over this period of time. Shift work was significantly associated with GHQ score and BMI. Results indicated that the shift workers had about 0.65 higher mean scores of GHQ than the day workers and 0.18 higher BMI (95% CI 0.17 to 1.14) and (95% CI 0.05 to 0.27), respectively. Shift work did not show significant relationship with hypercholesterolemia (95% CI -0.27 to 0.009). The results of the present study suggest that shift work may be directly responsible for increased body fatness and is associated with psychological problems.
本研究旨在研究轮班工作对超重和肥胖、高胆固醇血症和GHQ评分(GHQ-28)的影响，GHQ评分是伊朗西部马赫沙赫尔石化行业工作对象的心理健康指标。在这项纵向研究中，人口包括2493人(1321名白班工人和1171名轮班工人)，白班工人的平均年龄为46.18岁，轮班工人的平均年龄为45.53岁，为期四年(2008年至2011年)。采用波斯语版《一般健康问卷-28》(GHQ-28)作为筛选工具进行调查。测定血清胆固醇、身高和体重，高胆固醇血症的定义为血清总胆固醇220 mg/dl，超重和肥胖的定义为体重指数(BMI) 25 kg/ m2。采用条件联合随机效应模型方法来探讨轮班工作在这段时间内对多变量反应的影响。轮班工作与GHQ评分和BMI显著相关。结果表明，倒班工人的GHQ平均得分比白班工人高0.65,BMI平均得分比白班工人高0.18 (95% CI 0.17 ~ 1.14)和(95% CI 0.05 ~ 0.27)。轮班工作与高胆固醇血症没有显著关系(95% CI -0.27 ~ 0.009)。目前的研究结果表明，轮班工作可能直接导致身体肥胖，并与心理问题有关。
{"title":"Assessing the effect of shift work among petrochemical Industries staff at Mahshahr, Iran","authors":"M. Kazemi, A. Abadi, F. Zayeri, Hormoz Hassanzade","doi":"10.22037/JPS.V8I4.17017","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.17017","url":null,"abstract":"This study aims to examine the effect of shift work on overweight and obesity, hypercholesterolemia and GHQ score (GHQ-28) as an indicator of psychological well-being in subjects working in petrochemical industry sited in Mahshahr, west of Iran. In This longitudinal study, population consisted of 2493 (1321 day workers and 1171 shift workers) whose mean ages were 46.18 years for day workers and 45.53 years for shift workers, during a four years period (from 2008 to 2011). All workers were investigated by Persian version of General Health Questionnaire-28 (GHQ-28) as screen tool. The serum cholesterol, height and weight were measured with definitions of hypercholesterolemia as serum total cholesterol 220 mg/dl, overweight and obesity as body mass index (BMI) 25 kg/m 2 . A conditional joint random effects models approach was applied to explore the effect of shift working on multivariate responses over this period of time. Shift work was significantly associated with GHQ score and BMI. Results indicated that the shift workers had about 0.65 higher mean scores of GHQ than the day workers and 0.18 higher BMI (95% CI 0.17 to 1.14) and (95% CI 0.05 to 0.27), respectively. Shift work did not show significant relationship with hypercholesterolemia (95% CI -0.27 to 0.009). The results of the present study suggest that shift work may be directly responsible for increased body fatness and is associated with psychological problems.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72729432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Translating medical texts is a very risky and important task because these texts deal with human life and any mistake in their translation can be life threatening. However, physicians, as well as medical translators, do this task and believe that the quality of their translation is more better than one performed by the medical translators but due to lack of time, they have to employ medical translators for doing this task. The aim of this study was to assess the quality of medical translations performed by the two groups of medical translators and physicians using House's model. For this purpose, the book "Bate's Guide to Physical Examination and History Taking" written by Fiona R. Prabhu and Lynn S. Bickley published in 2003 (ST) and its two versions of Persian translation performed by two groups of medical translators (TT1) and physicians (TT2) were analyzed according to the steps described in the House's model and the mismatches (overt and covert errors) were determined. Then the translations were classified as over or covert translations and the reasons were described. The results show that neither medical translators (with English knowledge and translating skills) nor physicians (with Medical knowledge) can perform a high quality translation of medical texts alone and without cooperation with the other group. It was concluded that for presenting a high quality translation, medical translators and physicians should have cooperation with each other and a team of medical translators and physicians is required.
翻译医学文本是一项非常危险和重要的任务，因为这些文本涉及人类生命，翻译中的任何错误都可能危及生命。然而，医生以及医学翻译人员做这项任务，并认为他们的翻译质量比医学翻译人员的翻译质量要好，但由于时间不够，他们不得不聘请医学翻译人员来完成这项任务。本研究的目的是评估两组医学翻译人员和医生使用House模型进行医学翻译的质量。为此，由Fiona R. Prabhu和Lynn S. Bickley于2003年出版的《Bate’s Guide to Physical Examination and History Taking》一书，以及由两组医学翻译(TT1)和医生(TT2)进行的两个版本的波斯语翻译，根据众议院模型中描述的步骤进行了分析，并确定了不匹配(公开和隐蔽的错误)。然后将翻译分为过度翻译和隐蔽翻译，并分析了翻译的原因。结果表明，无论是医学翻译(具有英语知识和翻译技能)还是医生(具有医学知识)，如果没有另一组的合作，都无法完成高质量的医学文本翻译。结论是，为了提供高质量的翻译，医学翻译人员和医生应该相互合作，需要一个医学翻译人员和医生团队。
{"title":"Quality assessment of medical translations performed by the two groups of medical translators and physicians","authors":"Elahe Abootorabi, Seyed Nezamaddin Moeinzadeh","doi":"10.22037/jps.v8i4.16457","DOIUrl":"https://doi.org/10.22037/jps.v8i4.16457","url":null,"abstract":"Translating medical texts is a very risky and important task because these texts deal with human life and any mistake in their translation can be life threatening. However, physicians, as well as medical translators, do this task and believe that the quality of their translation is more better than one performed by the medical translators but due to lack of time, they have to employ medical translators for doing this task. The aim of this study was to assess the quality of medical translations performed by the two groups of medical translators and physicians using House's model. For this purpose, the book \"Bate's Guide to Physical Examination and History Taking\" written by Fiona R. Prabhu and Lynn S. Bickley published in 2003 (ST) and its two versions of Persian translation performed by two groups of medical translators (TT1) and physicians (TT2) were analyzed according to the steps described in the House's model and the mismatches (overt and covert errors) were determined. Then the translations were classified as over or covert translations and the reasons were described. The results show that neither medical translators (with English knowledge and translating skills) nor physicians (with Medical knowledge) can perform a high quality translation of medical texts alone and without cooperation with the other group. It was concluded that for presenting a high quality translation, medical translators and physicians should have cooperation with each other and a team of medical translators and physicians is required.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76847343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gholamreza Niaei, S. Heidaryan, A. Niaei, Nasim Alsadat Didevar
Endometriosis is considered as a multifactorial disease that affects up to 10% of all women of fertile age. Vascular endothelial growth factor (VEGF) is one of the most important activators of angiogenesis. VEGF is known to be a key molecule in the pathogenesis of endometriosis. A great number of studies have referred to genetic polymorphisms as a factor that contributes to the development of endometriosis. The present study was aimed to find out the frequency of the VEGF -1154G/A polymorphism and its relationship with endometriosis risk in Iranian women with endometriosis.This study involved 175 patients with endometriosis and 131 healthy controls. Following extraction of genomic DNA from patients and controls, genotyping of the -1154G/A polymorphism of the VEGF gene were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Multivariate analysis was used to examine the association between the risk of endometriosis and VEGF -1154G/A polymorphism. There was statistically a significant difference in the frequency of the -1154G/A polymorphism between patients and the controls. The percentage distribution of the three -1154G/A genotypes was (GG 3.4%, GA %46.8%, AA 49.7%) in endometriosis patients. Conclusion : Data supports the hypothesis that angiogenesis is of pivotal importance in the development of endometriosis. Our study indicates that there is significant association between the VEGF gene -1154G/A polymorphism and the risk of endometriosis in North West of Iran.
子宫内膜异位症被认为是一种多因素疾病，影响多达10%的育龄妇女。血管内皮生长因子(VEGF)是血管生成的重要激活因子之一。已知VEGF是子宫内膜异位症发病的关键分子。大量的研究已经提到遗传多态性是导致子宫内膜异位症发展的一个因素。本研究旨在了解伊朗子宫内膜异位症女性中VEGF -1154G/A多态性的频率及其与子宫内膜异位症风险的关系。这项研究涉及175名子宫内膜异位症患者和131名健康对照者。提取患者和对照组基因组DNA后，采用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)分析对VEGF基因-1154G/A多态性进行基因分型。采用多因素分析来研究子宫内膜异位症风险与VEGF -1154G/A多态性之间的关系。患者与对照组-1154G/ a多态性发生频率差异有统计学意义。3种-1154G/A基因型在子宫内膜异位症患者中的百分比分布为(GG 3.4%， GA 46.8%， AA 49.7%)。结论:数据支持血管生成在子宫内膜异位症的发展中起关键作用的假设。我们的研究表明，在伊朗西北部地区，VEGF基因-1154G/A多态性与子宫内膜异位症的风险存在显著相关性。
{"title":"Association between Vascular Endothelial Growth Factor (VEGF) -1154G/A Polymorphism and Endometriosis in North West of Iran","authors":"Gholamreza Niaei, S. Heidaryan, A. Niaei, Nasim Alsadat Didevar","doi":"10.22037/JPS.V8I4.16793","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.16793","url":null,"abstract":"Endometriosis is considered as a multifactorial disease that affects up to 10% of all women of fertile age. Vascular endothelial growth factor (VEGF) is one of the most important activators of angiogenesis. VEGF is known to be a key molecule in the pathogenesis of endometriosis. A great number of studies have referred to genetic polymorphisms as a factor that contributes to the development of endometriosis. The present study was aimed to find out the frequency of the VEGF -1154G/A polymorphism and its relationship with endometriosis risk in Iranian women with endometriosis.This study involved 175 patients with endometriosis and 131 healthy controls. Following extraction of genomic DNA from patients and controls, genotyping of the -1154G/A polymorphism of the VEGF gene were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Multivariate analysis was used to examine the association between the risk of endometriosis and VEGF -1154G/A polymorphism. There was statistically a significant difference in the frequency of the -1154G/A polymorphism between patients and the controls. The percentage distribution of the three -1154G/A genotypes was (GG 3.4%, GA %46.8%, AA 49.7%) in endometriosis patients. Conclusion : Data supports the hypothesis that angiogenesis is of pivotal importance in the development of endometriosis. Our study indicates that there is significant association between the VEGF gene -1154G/A polymorphism and the risk of endometriosis in North West of Iran.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72687906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phylogenetic networks are a generalization of phylogenetic trees which permit the representation the non-tree-like events. It is NP-hard to construct an optimal rooted phylogenetic network from a given set of rooted triplets. This paper presents a novel algorithm called RPNCH. For a given set of rooted triplets, RPNCH tries to construct a rooted phylogenetic network with the minimum number of reticulation nodes that contains all the given rooted triplets. The performance of RPNCH algorithm on simulated data is reported here.
{"title":"RPNCH: A method for constructing rooted phylogenetic networks from rooted triplets based on height function","authors":"M. Reyhani, Hadi Poormohammadi","doi":"10.22037/JPS.V8I4.16707","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.16707","url":null,"abstract":"Phylogenetic networks are a generalization of phylogenetic trees which permit the representation the non-tree-like events. It is NP-hard to construct an optimal rooted phylogenetic network from a given set of rooted triplets. This paper presents a novel algorithm called RPNCH. For a given set of rooted triplets, RPNCH tries to construct a rooted phylogenetic network with the minimum number of reticulation nodes that contains all the given rooted triplets. The performance of RPNCH algorithm on simulated data is reported here.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74195116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diarrhea is one of the gastrointestinal diseases that some reasons associated with an inappropriate of antibiotics treatment and, increased antibiotic resistance, has led to problems in the health system which vary in different societies. Control and resolution of this problem is necessary and the acquisition of a new group of antimicrobial compounds has been mentioned. So, this study aimed to determine the antibacterial activity of aqueous and alcoholic extracts of pomegranate seeds ( Punica granatum ) on common gastrointestinal producing bacteria. The antibacterial property of aqueous and alcoholic extracts of Punica granatum seeds against 100 bacteria was considered. Fifty and three isolates of E. coli , 19 isolates of Shigella sonneii , 8 isolates of Shigella flexneri , 5 isolates of Shigella dysentery , 7 strains of Proteus vulgaris , 5 isolates of Proteus mirabilis and 3 isolates of Citrobacter fraundii gathered from patients with diarrhea during July 2015-August 2016. Minimum inhibitory concentration (MIC) of various concentrations (mg/ml) of the extracts was used as an index of antimicrobial activity. The minimum inhibitory concentration of aqueous extract vs. ethanolic based on mg / ml were following: E. coli (75 vs 37.5), Shigella sonnei (37.5 vs., 18.75), Shigella flexneri (18.75 vs., 9.37), Shigella dysentery (18.75 vs., 9.37), Proteus vulgaris (18.75 vs., 9.37), Proteus mirabilis (9.37 vs., 9.37) and Citrobacter fraundii (150 vs., 75), respectively. The aqueous and alcoholic extracts had inhibitory effects on the studied bacteria, which affects the concentration of the substances used. Maybe, these inhibitory effects against each bacterium depend on effective substances and the type of the solvent properties. It is suggested to extract new antimicrobial compounds by chromatography to gain new antimicrobial agents.
腹泻是一种胃肠道疾病，一些原因与抗生素治疗不当和抗生素耐药性增加有关，导致卫生系统出现问题，在不同的社会有所不同。控制和解决这一问题是必要的，并提出了一组新的抗菌化合物。因此，本研究旨在研究石榴籽水提液和醇提液对常见胃肠道产菌的抑菌活性。研究了石榴籽水提液和醇提液对100种细菌的抑菌性能。2015年7月- 2016年8月从腹泻患者中分离出大肠杆菌53株、索内志贺氏菌19株、福氏志贺氏菌8株、痢疾志贺氏菌5株、寻常变形杆菌7株、奇异变形杆菌5株、弗朗地柠檬酸杆菌3株。以不同浓度提取物的最低抑菌浓度(MIC) (mg/ml)作为抑菌活性指标。基于mg / ml的水提物对乙醇的最低抑菌浓度分别为:大肠杆菌(75 vs. 37.5)、sonnei志贺氏菌(37.5 vs. 18.75)、flexneri志贺氏菌(18.75 vs. 9.37)、痢疾志贺氏菌(18.75 vs. 9.37)、普通变形杆菌(18.75 vs. 9.37)、奇异变形杆菌(9.37 vs. 9.37)和frundii柠檬酸杆菌(150 vs. 75)。水提液和醇提液对所研究的细菌都有抑制作用，这影响到所用物质的浓度。也许，这些对每种细菌的抑制作用取决于有效物质和溶剂性质的类型。建议采用色谱法提取新的抗菌化合物，以获得新的抗菌药物。
{"title":"The Antibacterial Properties of Aqueous and Alcoholic Extracts of Punica granatum Seeds on Infectious Diarrhea Produced by Bacteria","authors":"M. Navidinia, M. Goudarzi","doi":"10.22037/JPS.V8I4.17954","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.17954","url":null,"abstract":"Diarrhea is one of the gastrointestinal diseases that some reasons associated with an inappropriate of antibiotics treatment and, increased antibiotic resistance, has led to problems in the health system which vary in different societies. Control and resolution of this problem is necessary and the acquisition of a new group of antimicrobial compounds has been mentioned. So, this study aimed to determine the antibacterial activity of aqueous and alcoholic extracts of pomegranate seeds ( Punica granatum ) on common gastrointestinal producing bacteria. The antibacterial property of aqueous and alcoholic extracts of Punica granatum seeds against 100 bacteria was considered. Fifty and three isolates of E. coli , 19 isolates of Shigella sonneii , 8 isolates of Shigella flexneri , 5 isolates of Shigella dysentery , 7 strains of Proteus vulgaris , 5 isolates of Proteus mirabilis and 3 isolates of Citrobacter fraundii gathered from patients with diarrhea during July 2015-August 2016. Minimum inhibitory concentration (MIC) of various concentrations (mg/ml) of the extracts was used as an index of antimicrobial activity. The minimum inhibitory concentration of aqueous extract vs. ethanolic based on mg / ml were following: E. coli (75 vs 37.5), Shigella sonnei (37.5 vs., 18.75), Shigella flexneri (18.75 vs., 9.37), Shigella dysentery (18.75 vs., 9.37), Proteus vulgaris (18.75 vs., 9.37), Proteus mirabilis (9.37 vs., 9.37) and Citrobacter fraundii (150 vs., 75), respectively. The aqueous and alcoholic extracts had inhibitory effects on the studied bacteria, which affects the concentration of the substances used. Maybe, these inhibitory effects against each bacterium depend on effective substances and the type of the solvent properties. It is suggested to extract new antimicrobial compounds by chromatography to gain new antimicrobial agents.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74069422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Dehghan-Nayeri, Forouzan Bahmani, A. Gharehbaghian
Acute lymphoblastic leukemia (ALL) is the most common cancer among children. Despite recent treatment advances, about 80 percent of patients indicate resistance to treatment and the relapse remains a significant clinical problem. Apoptotic-resistant leukemia cells exhibit an unusual response to the NF-κB pathway; therefore, inhibiting this pathway can sensitize resistant cells to treatment. IKK-NF-kappaB signaling is an important factor in carciogenesis and a potential target for cancer treatment. Therefore, in this study, the mRNA expression of targets of NF-κB signaling including IKKalpha, IKKbeta and also NF-κB were analyzed, using the real time-PCR in the face of the combined effect of Curcuma longa and prednisolone in the ALL cell line of NALM-6. Results of the study showed significant downregulation of three genes after combination Curcuma longa (5 µg/ml) and prednisolone (1 μM) in comparison with the single agents alone. These findings unveiled the synergistic effect of Curcuma longa and prednisolone on IKKα and IKKβ downregulation and NF-κB inhibition that can be considered as a new approach in the ALL treatment of resistance to chemotherapy.
{"title":"In vitro antitumoral effects of the combination of Curcuma longa and prednisolone on inhibition of the NF-κB signaling pathway","authors":"N. Dehghan-Nayeri, Forouzan Bahmani, A. Gharehbaghian","doi":"10.22037/JPS.V8I4.17843","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.17843","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is the most common cancer among children. Despite recent treatment advances, about 80 percent of patients indicate resistance to treatment and the relapse remains a significant clinical problem. Apoptotic-resistant leukemia cells exhibit an unusual response to the NF-κB pathway; therefore, inhibiting this pathway can sensitize resistant cells to treatment. IKK-NF-kappaB signaling is an important factor in carciogenesis and a potential target for cancer treatment. Therefore, in this study, the mRNA expression of targets of NF-κB signaling including IKKalpha, IKKbeta and also NF-κB were analyzed, using the real time-PCR in the face of the combined effect of Curcuma longa and prednisolone in the ALL cell line of NALM-6. Results of the study showed significant downregulation of three genes after combination Curcuma longa (5 µg/ml) and prednisolone (1 μM) in comparison with the single agents alone. These findings unveiled the synergistic effect of Curcuma longa and prednisolone on IKKα and IKKβ downregulation and NF-κB inhibition that can be considered as a new approach in the ALL treatment of resistance to chemotherapy.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84112901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saeideh Valizadeh-Haghi, H. Moghaddasi, R. Rabiei, F. Asadi
Using health-related websites and their information increasingly develops and some concerns on its quality arise as well. Different factors affect the quality of health websites which visual structure is one of the most important factors. The aim of the current study is to explain the role of health websites` visual structure in users’ views on their quality and reliability as well as its role in obtaining health information by users. Furthermore, the need for a comprehensive guideline for designing such websites is discussed. The review showed that health website’s appearance has an important role in users view on its credibility. Furthermore, it was revealed that there is no comprehensive national or international guideline to health websites design. Considering the importance of visual structure of health websites, there is an emergent need to develop a national guideline to obviate the problems of non-consistent, poor or personalized design of health websites.
{"title":"Health websites visual structure: the necessity of developing a comprehensive design guideline","authors":"Saeideh Valizadeh-Haghi, H. Moghaddasi, R. Rabiei, F. Asadi","doi":"10.22037/JPS.V8I4.18175","DOIUrl":"https://doi.org/10.22037/JPS.V8I4.18175","url":null,"abstract":"Using health-related websites and their information increasingly develops and some concerns on its quality arise as well. Different factors affect the quality of health websites which visual structure is one of the most important factors. The aim of the current study is to explain the role of health websites` visual structure in users’ views on their quality and reliability as well as its role in obtaining health information by users. Furthermore, the need for a comprehensive guideline for designing such websites is discussed. The review showed that health website’s appearance has an important role in users view on its credibility. Furthermore, it was revealed that there is no comprehensive national or international guideline to health websites design. Considering the importance of visual structure of health websites, there is an emergent need to develop a national guideline to obviate the problems of non-consistent, poor or personalized design of health websites.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79705295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ahmadvand, Oranous Bashti, Ahmad Reza Salehi Chaleshtori, M. Noruzinia
Ataxia-telangiectasia is a rare disorder with neurological manifestations and caused by mutations in ATM gene. This gene produce a serine/threonine protein kinase, an activator of the DNA damage response in the face of DNA DSBs, which phosphorylates downstream substrates integrating with DNA repair procedure. Most ATM mutations are private mutations and, there is no mutational hotspots in the ATM gene. We unveiled a new mutation in this gene in an 8 years old A-T patient. This mutation led to fundamental alterations in ATM protein structure and representation of AT lastly.
{"title":"Novel Single Base Pair Deletion in ATM Cause Ataxia Telangiectasia in an Iranian Proband","authors":"M. Ahmadvand, Oranous Bashti, Ahmad Reza Salehi Chaleshtori, M. Noruzinia","doi":"10.22037/JPS.V8I3.12059","DOIUrl":"https://doi.org/10.22037/JPS.V8I3.12059","url":null,"abstract":"Ataxia-telangiectasia is a rare disorder with neurological manifestations and caused by mutations in ATM gene. This gene produce a serine/threonine protein kinase, an activator of the DNA damage response in the face of DNA DSBs, which phosphorylates downstream substrates integrating with DNA repair procedure. Most ATM mutations are private mutations and, there is no mutational hotspots in the ATM gene. We unveiled a new mutation in this gene in an 8 years old A-T patient. This mutation led to fundamental alterations in ATM protein structure and representation of AT lastly.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76479818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farzaneh Najar, M. Nasehi, S. Haeri-Rohani, M. Zarrindast
Most studies have found that changes in concentration of intracellular ions can change cell activation. Calcium ion is one of the most vital one of these ions which is the most vital second messenger within cells. Ca2+ is necessary for a wide range of cellular processes such as cell proliferation, muscle contraction and exocytosis and apoptosis. Different kinds of TRPCs (transient receptor potential cation channels) have a wide range of activity in cell but are known as Ca2+ blocker channel. On the other hand, cannabinoids are a class of different chemical compounds that act on cannabinoid receptors in cells that suppress neurotransmitter release in the brain. Ligands for these receptor proteins consist of endocannabinoids (produced naturally in the body of humans and animals), the phytocannabinoids (exist in cannabis and some other plants), and synthetic cannabinoids (artificially made). The most important cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive compound of cannabis. Cannabidiol (CBD) is another major part of the plant. It is showed that endocannabinoid biosynthesis is a calcium-dependent process, though the physiological source of calcium is not identified. Many of biochemical experiments have been investigating the contributions of extracellular and intracellular calcium in the biosynthetic process. Some studies found that extracellular calcium is a vital factor for the endogenous cannabinoids biosynthesis, while a simply releasing intracellular calcium store such as endoplasmic reticulum does not have an effect on endocannabinoid biosynthesis. In addition to introduction of cannabinoid, blocker of Ca2+ channel (TRPC) and investigating interaction among them in this review, the possible role of cannabinoid and TRPC3, TRPC6 and TRPV2 in behavioral process are induced in conclusion.
{"title":"the Possible role interaction between cannabinoid and TRPC3, TRPC6 and TRPV2 in behavioral process","authors":"Farzaneh Najar, M. Nasehi, S. Haeri-Rohani, M. Zarrindast","doi":"10.22037/JPS.V8I3.13595","DOIUrl":"https://doi.org/10.22037/JPS.V8I3.13595","url":null,"abstract":"Most studies have found that changes in concentration of intracellular ions can change cell activation. Calcium ion is one of the most vital one of these ions which is the most vital second messenger within cells. Ca2+ is necessary for a wide range of cellular processes such as cell proliferation, muscle contraction and exocytosis and apoptosis. Different kinds of TRPCs (transient receptor potential cation channels) have a wide range of activity in cell but are known as Ca2+ blocker channel. On the other hand, cannabinoids are a class of different chemical compounds that act on cannabinoid receptors in cells that suppress neurotransmitter release in the brain. Ligands for these receptor proteins consist of endocannabinoids (produced naturally in the body of humans and animals), the phytocannabinoids (exist in cannabis and some other plants), and synthetic cannabinoids (artificially made). The most important cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive compound of cannabis. Cannabidiol (CBD) is another major part of the plant. It is showed that endocannabinoid biosynthesis is a calcium-dependent process, though the physiological source of calcium is not identified. Many of biochemical experiments have been investigating the contributions of extracellular and intracellular calcium in the biosynthetic process. Some studies found that extracellular calcium is a vital factor for the endogenous cannabinoids biosynthesis, while a simply releasing intracellular calcium store such as endoplasmic reticulum does not have an effect on endocannabinoid biosynthesis. In addition to introduction of cannabinoid, blocker of Ca2+ channel (TRPC) and investigating interaction among them in this review, the possible role of cannabinoid and TRPC3, TRPC6 and TRPV2 in behavioral process are induced in conclusion.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85452589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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