Background: This study aimed to review the literature on the application of ImageJ in optical coherence tomography angiography (OCT-A) images.
Methods: A general search was performed in PubMed, Google Scholar, and Scopus databases. The authors evaluated each of the selected articles in order to assess the implementation of ImageJ in OCT-A images.
Results: ImageJ can aid in reducing artifacts, enhancing image quality to increase the accuracy of the process and analysis, processing and analyzing images, generating comparable parameters such as the parameters that assess perfusion of the layers (vessel density (VD), skeletonized density (SD), and vessel length density (VLD)) and the parameters that evaluate the structure of the layers (fractal dimension (FD), vessel density index (VDI), and lacunarity (LAC)), and the foveal avascular zone (FAZ) that are used widely in the retinal and choroidal studies), and establishing diagnostic criteria. It can help to save time when the dataset is huge with numerous plugins and options for image processing and analysis with reliable results. Diverse studies implemented distinct binarization and thresholding techniques, resulting in disparate outcomes and incomparable parameters. Uniformity in methodology is required to acquire comparable data from studies employing diverse processing and analysis techniques that yield varied outcomes.
Conclusion: Researchers and professionals might benefit from using ImageJ because of how quickly and correctly it processes and analyzes images. It is highly adaptable and potent software, allowing users to evaluate images in a variety of ways. There exists a diverse range of methodologies for analyzing OCTA images through the utilization of ImageJ. However, it is imperative to establish a standardized strategy to ensure the reliability and consistency of the method for research purposes.
{"title":"Application of ImageJ in Optical Coherence Tomography Angiography (OCT-A): A Literature Review.","authors":"Masoud Rahimi, Esmaeil Asadi Khameneh, Hamid Riazi-Esfahani, Tahereh Mahmoudi, Elias Khalili Pour, Rahele Kafieh","doi":"10.1155/2023/9479183","DOIUrl":"10.1155/2023/9479183","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to review the literature on the application of ImageJ in optical coherence tomography angiography (OCT-A) images.</p><p><strong>Methods: </strong>A general search was performed in PubMed, Google Scholar, and Scopus databases. The authors evaluated each of the selected articles in order to assess the implementation of ImageJ in OCT-A images.</p><p><strong>Results: </strong>ImageJ can aid in reducing artifacts, enhancing image quality to increase the accuracy of the process and analysis, processing and analyzing images, generating comparable parameters such as the parameters that assess perfusion of the layers (vessel density (VD), skeletonized density (SD), and vessel length density (VLD)) and the parameters that evaluate the structure of the layers (fractal dimension (FD), vessel density index (VDI), and lacunarity (LAC)), and the foveal avascular zone (FAZ) that are used widely in the retinal and choroidal studies), and establishing diagnostic criteria. It can help to save time when the dataset is huge with numerous plugins and options for image processing and analysis with reliable results. Diverse studies implemented distinct binarization and thresholding techniques, resulting in disparate outcomes and incomparable parameters. Uniformity in methodology is required to acquire comparable data from studies employing diverse processing and analysis techniques that yield varied outcomes.</p><p><strong>Conclusion: </strong>Researchers and professionals might benefit from using ImageJ because of how quickly and correctly it processes and analyzes images. It is highly adaptable and potent software, allowing users to evaluate images in a variety of ways. There exists a diverse range of methodologies for analyzing OCTA images through the utilization of ImageJ. However, it is imperative to establish a standardized strategy to ensure the reliability and consistency of the method for research purposes.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2023 ","pages":"9479183"},"PeriodicalIF":1.8,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-21eCollection Date: 2023-01-01DOI: 10.1155/2023/1950257
Edita Zvorničanin, Zoran Vatavuk, Maja Popović, Jasmin Zvorničanin
Purpose: The aim of the study is to determine the distribution and mutual relationship of ocular biometric parameters, as well as to evaluate gender- and age-related differences in patients undergoing cataract surgery in Bosnia and Herzegovina.
Materials and methods: It was a retrospective cross-sectional study of consecutive patients who underwent cataract surgery between January 2017 and December 2021 in a tertiary care clinic. All biometric measurements were performed using the optical biometer OA-2000 (Tomey, Nagoya, Japan).
Results: The study evaluated 1278 eyes from 1278 consecutive cataract patients. The average age of all included patients was 69.4 ± 9.98 (range 40-96). A total of 672 eyes (52.58%) were from females. The mean axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and mean keratometry were 23.46 ± 1.18 mm, 3.17 ± 0.40 mm, 4.54 ± 0.48 mm, and 43.42 ± 1.55D, respectively. Corneal astigmatism of ≥1D, >2D and >3D was found in 33.4%, 7.8% and 2.5% patients, respectively. Females were found to have shorter AL (p < 0.0001), shallower ACD (p < 0.0001) and steeper corneas (p < 0.0001). In both genders, AL, ACD and with the rule astigmatism showed a decreasing trend (p = 0.0001), while keratometry, the average cylinder, and against the rule astigmatism showed an increasing trend (p = 0.0001) with increasing age. Furthermore, in both genders, there was an increasing trend in ACD (p = 0.0001), and a decreasing trend in keratometry (p = 0.0001) and LT (p = 0.0001) with increasing AL.
Conclusions: This study provides useful reference data on ocular biometry for cataract surgeons in Bosnia and Herzegovina. Female patients tend to have steeper corneas, shorter AL and shallower AC than males, and these differences are independent of age or AL.
目的:研究的目的是确定眼部生物特征参数的分布和相互关系，以及评估波斯尼亚和黑塞哥维那白内障手术患者的性别和年龄相关差异。材料和方法:这是一项回顾性横断面研究，纳入了2017年1月至2021年12月在三级保健诊所接受白内障手术的连续患者。所有生物测量均使用OA-2000光学生物计(Tomey，名古屋，日本)进行。结果:本研究对1278例连续白内障患者的1278只眼进行了评估。所有患者的平均年龄为69.4±9.98岁(40 ~ 96岁)。女性672只，占52.58%。平均眼轴长(AL)、前房深度(ACD)、晶状体厚度(LT)、平均角膜度数分别为23.46±1.18 mm、3.17±0.40 mm、4.54±0.48 mm、43.42±1.55D。角膜散光≥1D、>2D和>3D分别占33.4%、7.8%和2.5%。女性AL较短(p p p p = 0.0001)，随着年龄的增长，角膜度数、平均柱体、反规则散光呈增加趋势(p = 0.0001)。此外，随着al的增加，男女ACD呈上升趋势(p = 0.0001)，角膜度数(p = 0.0001)和LT呈下降趋势(p = 0.0001)。结论:本研究为波黑白内障手术提供了有用的眼生物测量参考数据。女性患者的角膜比男性更陡，AL更短，AC更浅，这些差异与年龄或AL无关。
{"title":"Gender- and Age-Related Differences of Ocular Biometric Parameters in Patients Undergoing Cataract Surgery in Bosnia and Herzegovina.","authors":"Edita Zvorničanin, Zoran Vatavuk, Maja Popović, Jasmin Zvorničanin","doi":"10.1155/2023/1950257","DOIUrl":"10.1155/2023/1950257","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study is to determine the distribution and mutual relationship of ocular biometric parameters, as well as to evaluate gender- and age-related differences in patients undergoing cataract surgery in Bosnia and Herzegovina.</p><p><strong>Materials and methods: </strong>It was a retrospective cross-sectional study of consecutive patients who underwent cataract surgery between January 2017 and December 2021 in a tertiary care clinic. All biometric measurements were performed using the optical biometer OA-2000 (Tomey, Nagoya, Japan).</p><p><strong>Results: </strong>The study evaluated 1278 eyes from 1278 consecutive cataract patients. The average age of all included patients was 69.4 ± 9.98 (range 40-96). A total of 672 eyes (52.58%) were from females. The mean axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and mean keratometry were 23.46 ± 1.18 mm, 3.17 ± 0.40 mm, 4.54 ± 0.48 mm, and 43.42 ± 1.55D, respectively. Corneal astigmatism of ≥1D, >2D and >3D was found in 33.4%, 7.8% and 2.5% patients, respectively. Females were found to have shorter AL (<i>p</i> < 0.0001), shallower ACD (<i>p</i> < 0.0001) and steeper corneas (<i>p</i> < 0.0001). In both genders, AL, ACD and with the rule astigmatism showed a decreasing trend (<i>p</i> = 0.0001), while keratometry, the average cylinder, and against the rule astigmatism showed an increasing trend (<i>p</i> = 0.0001) with increasing age. Furthermore, in both genders, there was an increasing trend in ACD (<i>p</i> = 0.0001), and a decreasing trend in keratometry (<i>p</i> = 0.0001) and LT (<i>p</i> = 0.0001) with increasing AL.</p><p><strong>Conclusions: </strong>This study provides useful reference data on ocular biometry for cataract surgeons in Bosnia and Herzegovina. Female patients tend to have steeper corneas, shorter AL and shallower AC than males, and these differences are independent of age or AL.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2023 ","pages":"1950257"},"PeriodicalIF":1.9,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei-Yu Chiang, Shih-Chou Chen, Shwu-Jiuan Sheu, Hsi-Kung Kuo
In this study, we reported the patterns, epidemiology, and clinical features of anterior uveitis (AU) in Taiwan, an area of Eastern Asia. This prospective, cross-sectional case series study was performed to identify patients with AU at two tertiary medical centers (Kaohsiung Chang Gung Memorial Hospital and Kaohsiung Veterans General Hospital) located at the southern Taiwan between December 1, 2018, and March 31, 2020. The clinical diagnoses, ocular presentations, and laboratory data, including the results of the aqueous polymerase chain reaction tests, were investigated in these patients. A total of 112 patients, with a mean age of 48.9 years, were included. Most patients (87.5%) presented with unilateral eye disease, with 30 cases of ocular hypertension at the first presentation (27%). The most common clinical diagnoses were idiopathic AU (37.5%), human leukocyte antigen (HLA)-B27-associated acute AU (25.0%), and herpetic AU (18.8%). Among patients with herpetic AU, cytomegalovirus (CMV) was the most common pathogen (17/21, 81%). Compared to HLA-B27-associated acute AU, CMV-related AU was mostly observed in patients that were older in age, exhibited higher intraocular pressure, more keratic precipitates, greater iris atrophy, and more pseudophakia, but was least reported in those with posterior synechiae. This prospective study identified the pattern and clinical features of AU in southern Taiwan.
{"title":"A Prospective Study of Clinical Features of Anterior Uveitis in Taiwan","authors":"Wei-Yu Chiang, Shih-Chou Chen, Shwu-Jiuan Sheu, Hsi-Kung Kuo","doi":"10.1155/2023/9647418","DOIUrl":"https://doi.org/10.1155/2023/9647418","url":null,"abstract":"In this study, we reported the patterns, epidemiology, and clinical features of anterior uveitis (AU) in Taiwan, an area of Eastern Asia. This prospective, cross-sectional case series study was performed to identify patients with AU at two tertiary medical centers (Kaohsiung Chang Gung Memorial Hospital and Kaohsiung Veterans General Hospital) located at the southern Taiwan between December 1, 2018, and March 31, 2020. The clinical diagnoses, ocular presentations, and laboratory data, including the results of the aqueous polymerase chain reaction tests, were investigated in these patients. A total of 112 patients, with a mean age of 48.9 years, were included. Most patients (87.5%) presented with unilateral eye disease, with 30 cases of ocular hypertension at the first presentation (27%). The most common clinical diagnoses were idiopathic AU (37.5%), human leukocyte antigen (HLA)-B27-associated acute AU (25.0%), and herpetic AU (18.8%). Among patients with herpetic AU, cytomegalovirus (CMV) was the most common pathogen (17/21, 81%). Compared to HLA-B27-associated acute AU, CMV-related AU was mostly observed in patients that were older in age, exhibited higher intraocular pressure, more keratic precipitates, greater iris atrophy, and more pseudophakia, but was least reported in those with posterior synechiae. This prospective study identified the pattern and clinical features of AU in southern Taiwan.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"35 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-06eCollection Date: 2023-01-01DOI: 10.1155/2023/9212524
Bar Davidov, Avi Ohayon, Omer Trivizki, Shulamit Schwartz, Shiri Shulman
Purpose: Postintravitreal injection (IVI) endophthalmitis is a rare but devastating complication. Herein, we report the incidence ,and clinical and microbiological characteristics, as well as the visual outcome, in IVIs endophthalmitis in two medical centers.
Methods: All patients undergoing intravitreal injections between 1/2018 and 12/2019 in two large medical centers were analyzed for post-IVI endophthalmitis.
Results: Of the total of 51,356 IVIs performed, 23 cases of post-IVI endophthalmitis were diagnosed, yielding an overall incidence of 0.045%. The median interval from IVI to symptoms onset was 2 days (IQR: 1-5). Cultures were positive in 56% of the cases (100% Gram-positive bacteria and 76% coagulase-negative staphylococcus). Parameters associated with higher culture-positive rates included samples taken during vitrectomy, WBC on vitreous smear, the number of IVIs in the 12 months prior to presentation, and the time interval from last IVI to diagnostic sampling. At 6- and 12-month follow-up, the median change in VA (logMAR) was -1.10 (IQR: (-1.32)-(-0.40)) and -1.02 (IQR: (-1.10)-(-0.30)), respectively. Younger age and better BCVA at presentation were associated with better VA outcome, while positive culture result and systemic steroids treatment were each associated with the worse visual outcome. We found no difference in visual outcomes between PPV and TAI as a primary procedure.
Conclusion: Post-IVI endophthalmitis is a rare complication, and most patients do not regain their initial VA. Certain parameters (clinical, microbiological, and therapeutic) may help anticipate the outcome and guide decision making regarding diagnosis and treatment.
{"title":"Postintravitreal Injection Endophthalmitis: Incidence, Characteristics, Management, and Outcome.","authors":"Bar Davidov, Avi Ohayon, Omer Trivizki, Shulamit Schwartz, Shiri Shulman","doi":"10.1155/2023/9212524","DOIUrl":"10.1155/2023/9212524","url":null,"abstract":"<p><strong>Purpose: </strong>Postintravitreal injection (IVI) endophthalmitis is a rare but devastating complication. Herein, we report the incidence ,and clinical and microbiological characteristics, as well as the visual outcome, in IVIs endophthalmitis in two medical centers.</p><p><strong>Methods: </strong>All patients undergoing intravitreal injections between 1/2018 and 12/2019 in two large medical centers were analyzed for post-IVI endophthalmitis.</p><p><strong>Results: </strong>Of the total of 51,356 IVIs performed, 23 cases of post-IVI endophthalmitis were diagnosed, yielding an overall incidence of 0.045%. The median interval from IVI to symptoms onset was 2 days (IQR: 1-5). Cultures were positive in 56% of the cases (100% Gram-positive bacteria and 76% coagulase-negative <i>staphylococcus</i>). Parameters associated with higher culture-positive rates included samples taken during vitrectomy, WBC on vitreous smear, the number of IVIs in the 12 months prior to presentation, and the time interval from last IVI to diagnostic sampling. At 6- and 12-month follow-up, the median change in VA (logMAR) was -1.10 (IQR: (-1.32)-(-0.40)) and -1.02 (IQR: (-1.10)-(-0.30)), respectively. Younger age and better BCVA at presentation were associated with better VA outcome, while positive culture result and systemic steroids treatment were each associated with the worse visual outcome. We found no difference in visual outcomes between PPV and TAI as a primary procedure.</p><p><strong>Conclusion: </strong>Post-IVI endophthalmitis is a rare complication, and most patients do not regain their initial VA. Certain parameters (clinical, microbiological, and therapeutic) may help anticipate the outcome and guide decision making regarding diagnosis and treatment.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2023 ","pages":"9212524"},"PeriodicalIF":1.9,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31288/oftalmolzh20235310
Зоя Розанова, Миколай Уманець, Наталя Храменко, Алла Невська, Інес Буаллагуі
Purpose: To compare fovea-sparing and conventional internal limiting membrane (ILM) peeling in idiopathic macular hole (IMH) surgery in terms of IMH closure type, hole closure incidence and visual outcome. Material and Methods: The ILM was peeled around the IMH in the conventional ILM peeling group. In the fovea-sparing ILM peeling group, an ILM flap was created temporally to the IMH (with an ILM remnant left attached to the margins of the IMH), folded over the hole and stabilized with viscoelastic. Gas tamponade with 20% SF6 or 15% С3F8 was used. In the postoperative period, IMH closure pattern was assessed. Thicknesses of the outer retinal layers, inner retinal layers and retinal nerve fiber layer in the macular region were measured at 1 and 3 months. Results: Totally, 70 patients (15 males and 55 females) had an IMH surgery in 71 eyes. The mean age (SD) was 65.7 (6.8) years. The median IMH duration (interquartile range (IQR)) was 3.0 (1.0-6.0) months, and the mean preoperative BCVA (standard deviation (SD)), 0.19 (0.16). Thirty-four eyes had an IMH surgery with conventional ILM peeling, and 37 eyes, an IMH surgery with fovea-sparing ILM peeling. The two groups were matched in terms of preoperative visual acuity and macular hole duration. IMH closure was achieved in 30/34 eyes (88.2%) in the conventional ILM peeling group and 33/37 eyes (89.2%) in the fovea-sparing ILM peeling group. Particularly, IMH closure was achieved in 13/17 eyes that received gas tamponade with 20% SF6 and 20/20 eyes that received that with 15% С3F8 in the latter group. The rate of correct IMH closure pattern was substantially higher (64% versus 47%) and median postoperative BCVA (IQR), significantly better (0.55 (0.35-0.7) versus 0.43 (0.35-0.6), р = 0.039) in the fovea-sparing ILM peeling group than in the conventional ILM peeling group. An analysis of variance found a significant effect of the type of IMH surgery and IMH closure pattern on the postoperative BCVA (F1 = 5.06, p = 0.027; F2 = 7.9, p = 0.0001). In both groups, we found a significant thinning of the total retinal thickness in the central 1-mm foveal zone at 3 months compared to 1 month after surgery. There was a significant thinning of the outer and inner retinal layers in the conventional ILM peeling group, and no significant thickness changes in the retinal layers in the fovea-sparing group. Conclusion: Our fovea-sparing ILM peeling technique is an effective treatment option for IMHs, and when used with gas tamponade with 15% С3F8, enabled a primary surgery IMH closure rate of 100%.
{"title":"Anatomical and functional outcomes of idiopathic macular hole surgery with fovea-sparing versus conventional internal limiting membrane peeling","authors":"Зоя Розанова, Миколай Уманець, Наталя Храменко, Алла Невська, Інес Буаллагуі","doi":"10.31288/oftalmolzh20235310","DOIUrl":"https://doi.org/10.31288/oftalmolzh20235310","url":null,"abstract":"Purpose: To compare fovea-sparing and conventional internal limiting membrane (ILM) peeling in idiopathic macular hole (IMH) surgery in terms of IMH closure type, hole closure incidence and visual outcome. Material and Methods: The ILM was peeled around the IMH in the conventional ILM peeling group. In the fovea-sparing ILM peeling group, an ILM flap was created temporally to the IMH (with an ILM remnant left attached to the margins of the IMH), folded over the hole and stabilized with viscoelastic. Gas tamponade with 20% SF6 or 15% С3F8 was used. In the postoperative period, IMH closure pattern was assessed. Thicknesses of the outer retinal layers, inner retinal layers and retinal nerve fiber layer in the macular region were measured at 1 and 3 months. Results: Totally, 70 patients (15 males and 55 females) had an IMH surgery in 71 eyes. The mean age (SD) was 65.7 (6.8) years. The median IMH duration (interquartile range (IQR)) was 3.0 (1.0-6.0) months, and the mean preoperative BCVA (standard deviation (SD)), 0.19 (0.16). Thirty-four eyes had an IMH surgery with conventional ILM peeling, and 37 eyes, an IMH surgery with fovea-sparing ILM peeling. The two groups were matched in terms of preoperative visual acuity and macular hole duration. IMH closure was achieved in 30/34 eyes (88.2%) in the conventional ILM peeling group and 33/37 eyes (89.2%) in the fovea-sparing ILM peeling group. Particularly, IMH closure was achieved in 13/17 eyes that received gas tamponade with 20% SF6 and 20/20 eyes that received that with 15% С3F8 in the latter group. The rate of correct IMH closure pattern was substantially higher (64% versus 47%) and median postoperative BCVA (IQR), significantly better (0.55 (0.35-0.7) versus 0.43 (0.35-0.6), р = 0.039) in the fovea-sparing ILM peeling group than in the conventional ILM peeling group. An analysis of variance found a significant effect of the type of IMH surgery and IMH closure pattern on the postoperative BCVA (F1 = 5.06, p = 0.027; F2 = 7.9, p = 0.0001). In both groups, we found a significant thinning of the total retinal thickness in the central 1-mm foveal zone at 3 months compared to 1 month after surgery. There was a significant thinning of the outer and inner retinal layers in the conventional ILM peeling group, and no significant thickness changes in the retinal layers in the fovea-sparing group. Conclusion: Our fovea-sparing ILM peeling technique is an effective treatment option for IMHs, and when used with gas tamponade with 15% С3F8, enabled a primary surgery IMH closure rate of 100%.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135320522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31288/oftalmolzh202355659
Natalia Kuková, Maria Molnarova, Jana Stefanickova
Proton beam therapy is a globe preserving treatment method of choroidal melanoma. It is considered to be less harmful for the tissues around the tumour but the complications such as radiation retinopathy and neuropathy occur according to the dosage of irradiation. The visual outcomes after treatment are variable and dependent on the size of tumour. This article presents a case report of a 44-year-old male with choroidal melanoma in the left eye. Patient was examined in our ophthalmology practice because of photopsia and blurry vision during physical activity. After full ophthalmologic examination, fundus photography, optic coherent tomography, fluoresceine angiography and ultrasonography the diagnosis of malignant melanoma of choroid was set. The patient was referred to a proton center to undergo a proton therapy of choroidal melanoma in the left eye. Follow-up treatment of severe postradiation retinopathy and neuropathy is presented in the article. The patient took intravitreal bevacizumab injections and the panretinal lasercoagulation was performed. After one and half year follow up the melanoma is stable after therapy with no metastases.
{"title":"Complications after proton therapy of choroidal melanoma: A case report","authors":"Natalia Kuková, Maria Molnarova, Jana Stefanickova","doi":"10.31288/oftalmolzh202355659","DOIUrl":"https://doi.org/10.31288/oftalmolzh202355659","url":null,"abstract":"Proton beam therapy is a globe preserving treatment method of choroidal melanoma. It is considered to be less harmful for the tissues around the tumour but the complications such as radiation retinopathy and neuropathy occur according to the dosage of irradiation. The visual outcomes after treatment are variable and dependent on the size of tumour. This article presents a case report of a 44-year-old male with choroidal melanoma in the left eye. Patient was examined in our ophthalmology practice because of photopsia and blurry vision during physical activity. After full ophthalmologic examination, fundus photography, optic coherent tomography, fluoresceine angiography and ultrasonography the diagnosis of malignant melanoma of choroid was set. The patient was referred to a proton center to undergo a proton therapy of choroidal melanoma in the left eye. Follow-up treatment of severe postradiation retinopathy and neuropathy is presented in the article. The patient took intravitreal bevacizumab injections and the panretinal lasercoagulation was performed. After one and half year follow up the melanoma is stable after therapy with no metastases.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"77 13-14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31288/oftalmolzh202352733
Ю. М. Самченко, С. М. Дибкова, Анатолій Малецький, Л. О. Керносенко, Т. Г. Грузіна, Н. О. Пасмурцева, Л. С. Рєзніченко, О. Б. Лютко, К. В. Вітрак, Н. М. Бігун, П. В. Воротицький, І. Є. Мамишев
Background: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs). Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area. Material and Methods: A 30% aqueous solution of albucide was used in the study. Antimicrobial activity of synthesized hydrogels was determined using Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29213, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains. Results: All the synthesized samples of orbital hydrogel implants were sterile. The synthesized hydrogels and hydrogel nanocomposites with incorporated Au nanoparticles demonstrated bacteriostatic effects against E. Coli ATCC 25922, E. Faecalis ATCC 29213, and S. Aureus ATCC 25923 strains, and bactericidal effects against P. Aeruginosa ATCC 27853 strain. This study also demonstrated marked bactericidal effects of hybrid hydrogel implants incorporating both Au nanoparticles and albucide. Conclusion: Orbital hydrogel implants were found to be sterile after being sealed into polypropylene bags and steam sterilized at 121 °C for 20 minutes. Our findings of bacteriostatic and bactericidal effects of the synthesized hydrogels and hydrogel nanocomposites containing Au nanoparticles and albucide against bacterial strains of interest will allow for the absence of, or low probability of bacterial contamination in applications of these hydrogels in implants.
{"title":"Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area","authors":"Ю. М. Самченко, С. М. Дибкова, Анатолій Малецький, Л. О. Керносенко, Т. Г. Грузіна, Н. О. Пасмурцева, Л. С. Рєзніченко, О. Б. Лютко, К. В. Вітрак, Н. М. Бігун, П. В. Воротицький, І. Є. Мамишев","doi":"10.31288/oftalmolzh202352733","DOIUrl":"https://doi.org/10.31288/oftalmolzh202352733","url":null,"abstract":"Background: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs). Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area. Material and Methods: A 30% aqueous solution of albucide was used in the study. Antimicrobial activity of synthesized hydrogels was determined using Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29213, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains. Results: All the synthesized samples of orbital hydrogel implants were sterile. The synthesized hydrogels and hydrogel nanocomposites with incorporated Au nanoparticles demonstrated bacteriostatic effects against E. Coli ATCC 25922, E. Faecalis ATCC 29213, and S. Aureus ATCC 25923 strains, and bactericidal effects against P. Aeruginosa ATCC 27853 strain. This study also demonstrated marked bactericidal effects of hybrid hydrogel implants incorporating both Au nanoparticles and albucide. Conclusion: Orbital hydrogel implants were found to be sterile after being sealed into polypropylene bags and steam sterilized at 121 °C for 20 minutes. Our findings of bacteriostatic and bactericidal effects of the synthesized hydrogels and hydrogel nanocomposites containing Au nanoparticles and albucide against bacterial strains of interest will allow for the absence of, or low probability of bacterial contamination in applications of these hydrogels in implants.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"33 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31288/oftalmolzh202354145
N. F. Bobrova, T. A. Sorochynska, S. A. Tronina, T. V. Romanova, N. I. Molachaniuk, O. Iu. Bratishko, A. V. Shylyk
Background: In recent years, there have been individual reports on intracameral chemotherapy (ICC) for aqueous seeding in retinoblastoma. The effect of melphalan on the structures of the ocular anterior segment (including the cornea, iris and anterior lens capsule) is however, still unknown, since no relevant experimental studies have been carried out so far. Purpose: To experimentally assess the changes in the rabbit anterior segment induced by intracameral injection of various concentrations of the alkylating cytostatic melphalan. Material and Methods: Twelve adult Chinchilla rabbits (22 eyes; age, 5–6 months; weight, 2.5–3 kg) were involved in this experimental study and maintained in the vivarium of the Filatov institute in separate cages under standard conditions. Results: After a 5-µg melphalan injection, corneal and iris changes were reversible and the lens was still clear. With an increase in melphalan concentration in injection solution (to 10, 15 and 20 µg) and time point (to 1 month and 3 weeks) after injection, degenerative changes in some epithelial cells of the iris became irreversible, anterior capsular cataract developed, but the cornea and anterior chamber aqueous remained clear. After a single 20-µg intracameral injection of melphalan, there was depigmentation of the iris, posterior synechia and anterior capsular cataract. Conclusion: Clinical and ultrastructural responses of ocular anterior segment tissue to intracameral melphalan injection depended on the injected dose and time point after injection. Most cells of examined tissues showed the capability to restore their ultrastructure following ceasing of the toxic effect of the drug.
{"title":"Clinical and pathomorphological changes in the rabbit retina after an injection of various doses of the cytostatic melphalan","authors":"N. F. Bobrova, T. A. Sorochynska, S. A. Tronina, T. V. Romanova, N. I. Molachaniuk, O. Iu. Bratishko, A. V. Shylyk","doi":"10.31288/oftalmolzh202354145","DOIUrl":"https://doi.org/10.31288/oftalmolzh202354145","url":null,"abstract":"Background: In recent years, there have been individual reports on intracameral chemotherapy (ICC) for aqueous seeding in retinoblastoma. The effect of melphalan on the structures of the ocular anterior segment (including the cornea, iris and anterior lens capsule) is however, still unknown, since no relevant experimental studies have been carried out so far. Purpose: To experimentally assess the changes in the rabbit anterior segment induced by intracameral injection of various concentrations of the alkylating cytostatic melphalan. Material and Methods: Twelve adult Chinchilla rabbits (22 eyes; age, 5–6 months; weight, 2.5–3 kg) were involved in this experimental study and maintained in the vivarium of the Filatov institute in separate cages under standard conditions. Results: After a 5-µg melphalan injection, corneal and iris changes were reversible and the lens was still clear. With an increase in melphalan concentration in injection solution (to 10, 15 and 20 µg) and time point (to 1 month and 3 weeks) after injection, degenerative changes in some epithelial cells of the iris became irreversible, anterior capsular cataract developed, but the cornea and anterior chamber aqueous remained clear. After a single 20-µg intracameral injection of melphalan, there was depigmentation of the iris, posterior synechia and anterior capsular cataract. Conclusion: Clinical and ultrastructural responses of ocular anterior segment tissue to intracameral melphalan injection depended on the injected dose and time point after injection. Most cells of examined tissues showed the capability to restore their ultrastructure following ceasing of the toxic effect of the drug.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"71 11-12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31288/oftalmolzh202356364
Наталя Храменко
It is with deep regret that we share sad news of the passing of Professor Valerii Semenovych Ponomarchuk, Head of the Functional Diagnostics Department at the Filatov Institute of Eye Diseases and Tissue Therapy, Dr Sc (Med) and Merited Doctor of Ukraine, who died on 12 September 2023. Valerii Semenovych was born on June 2, 1948, in Mykolaiv region, Ukraine. After completing his secondary school education, he went on to Odesa Medical School in 1964 which he graduated with Honors to become a medical assistant. After graduating with Honors in General Medicine at the Pirogov Odesa Medical Institute, he began his career as a junior researcher at the Functional Diagnostics Laboratory, the Filatov Institute of Eye Diseases and Tissue Therapy, in 1974. Valerii Semenovych was promoted to senior researcher and head of the Functional Diagnostics Department in 1987, and remained at the head of the department until his death. His first significant academic achievement was defending his Cand Sc (Med) thesis, Loss of Intraocular Pressure Control Secondary to Effects Exerted on Limbic System Structures, in 1981. He defended his doctoral (Dr Sc (Med)) dissertation, Early Functional Changes in the Visual System and the Pathological Mechanisms of These Changes in Autonomic Nervous System Dysfunction, in 1995, and was awarded the title of professor in 1998. Professor Ponomarchuk was academic secretary for the Dissertation Defense Council specializing in ophthalmology, from 1996 to 2006; expert of the State Dissertation Defense Board in clinical medicine, from 2006 to 2012; and expert of the State Commission for Academic Degrees and Titles at the Ministry of Education, Science, Youth and Sport of Ukraine in clinical medicine (surgical disorders), from 2012 to 2014. In 2002, he was elected a Vice-President of the Ukrainian Ophthalmological Society. His research and practical activities were focused on the physiology of vision, early functional diagnosis of disorders of the eye and visual system, and efficacy of treating various eye diseases with low-intensity physical stimuli (e.g., electric stimulation, photic stimulation and muscle stimulation). Professor Ponomarchuk also conducted studies on the effects of autonomic nervous system dysfunction on the eye, and the results of these studies laid down the foundation for a new area of ophthalmology, vegetoophthalmology. He developed various sets of techniques (electrophysiology techniques; studies of the central and peripheral fields of vision, cerebral and ocular circulation, and light sensitivity) for pre-clinical diagnosis of visual system disorders and comprehensive color vision evaluation. These techniques are successfully used at the Filatov institute and many eye centers of Ukraine. Professor Ponomarchuk was an active inventor. In 1988, he began his collaboration with engineers of “Shtorm” Research Institute to develop a number of diagnostic and treatment devices (ophthalmological electric and photic stimulators
{"title":"In Memoriam: Valerii Semenovych Ponomarchuk","authors":"Наталя Храменко","doi":"10.31288/oftalmolzh202356364","DOIUrl":"https://doi.org/10.31288/oftalmolzh202356364","url":null,"abstract":"It is with deep regret that we share sad news of the passing of Professor Valerii Semenovych Ponomarchuk, Head of the Functional Diagnostics Department at the Filatov Institute of Eye Diseases and Tissue Therapy, Dr Sc (Med) and Merited Doctor of Ukraine, who died on 12 September 2023. Valerii Semenovych was born on June 2, 1948, in Mykolaiv region, Ukraine. After completing his secondary school education, he went on to Odesa Medical School in 1964 which he graduated with Honors to become a medical assistant. After graduating with Honors in General Medicine at the Pirogov Odesa Medical Institute, he began his career as a junior researcher at the Functional Diagnostics Laboratory, the Filatov Institute of Eye Diseases and Tissue Therapy, in 1974. Valerii Semenovych was promoted to senior researcher and head of the Functional Diagnostics Department in 1987, and remained at the head of the department until his death. His first significant academic achievement was defending his Cand Sc (Med) thesis, Loss of Intraocular Pressure Control Secondary to Effects Exerted on Limbic System Structures, in 1981. He defended his doctoral (Dr Sc (Med)) dissertation, Early Functional Changes in the Visual System and the Pathological Mechanisms of These Changes in Autonomic Nervous System Dysfunction, in 1995, and was awarded the title of professor in 1998. Professor Ponomarchuk was academic secretary for the Dissertation Defense Council specializing in ophthalmology, from 1996 to 2006; expert of the State Dissertation Defense Board in clinical medicine, from 2006 to 2012; and expert of the State Commission for Academic Degrees and Titles at the Ministry of Education, Science, Youth and Sport of Ukraine in clinical medicine (surgical disorders), from 2012 to 2014. In 2002, he was elected a Vice-President of the Ukrainian Ophthalmological Society. His research and practical activities were focused on the physiology of vision, early functional diagnosis of disorders of the eye and visual system, and efficacy of treating various eye diseases with low-intensity physical stimuli (e.g., electric stimulation, photic stimulation and muscle stimulation). Professor Ponomarchuk also conducted studies on the effects of autonomic nervous system dysfunction on the eye, and the results of these studies laid down the foundation for a new area of ophthalmology, vegetoophthalmology. He developed various sets of techniques (electrophysiology techniques; studies of the central and peripheral fields of vision, cerebral and ocular circulation, and light sensitivity) for pre-clinical diagnosis of visual system disorders and comprehensive color vision evaluation. These techniques are successfully used at the Filatov institute and many eye centers of Ukraine. Professor Ponomarchuk was an active inventor. In 1988, he began his collaboration with engineers of “Shtorm” Research Institute to develop a number of diagnostic and treatment devices (ophthalmological electric and photic stimulators ","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"79 17-18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31288/oftalmolzh202355962
Ксенія Трояновська, Андрій Король, Оксана Блавацька, І. І. Желтвай
Postage stamps as a means of propaganda to promote eye examination and vision screening
以邮票作为宣传手段，推广眼科检查及视力普查
{"title":"Postage stamps as a means of propaganda to promote eye examination and vision screening","authors":"Ксенія Трояновська, Андрій Король, Оксана Блавацька, І. І. Желтвай","doi":"10.31288/oftalmolzh202355962","DOIUrl":"https://doi.org/10.31288/oftalmolzh202355962","url":null,"abstract":"Postage stamps as a means of propaganda to promote eye examination and vision screening","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"231 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135326061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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