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A Cross-Sectional Study of Myopia and Morning Melatonin Status in Northern Irish Adolescent Children. 北爱尔兰青少年近视和早晨褪黑激素状况的横断面研究。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-11-01 eCollection Date: 2023-01-01 DOI: 10.1155/2023/7961623
Jane M Fulton, Sarah C Flanagan, Julie J Sittlington, Diego Cobice, Sara Dobbin, Sara J McCullough, Gareth Orr, Patrick Richardson, Kathryn J Saunders

Purpose: Previous studies have demonstrated an association between melatonin status and both refractive error and axial length in young adult myopes. This study aimed to determine if this relationship extends to a younger adolescent cohort.

Methods: Healthy children aged 12-15 years provided morning saliva samples before attending Ulster University (55°N) for cycloplegic autorefraction and axial length measures. Participants completed questionnaires describing recent sleep habits and physical activity. Salivary melatonin was quantified using high-performance liquid chromatography-tandem mass spectrometry. Data collection for all participants occurred over a 1-week period (April 2021).

Results: Seventy participants aged 14.3 (95% CI: 14.2-14.5) years were categorised by spherical equivalent refraction [SER] (range: -5.38DS to +1.88DS) into two groups; myopic SER ≤ -0.50DS (n = 22) or nonmyopic -0.50DS < SER ≤ +2.00DS (n = 48). Median morning salivary melatonin levels were 4.52 pg/ml (95% CI: 2.60-6.02) and 4.89 pg/ml (95% CI: 3.18-5.66) for myopic and nonmyopic subjects, respectively, and did not differ significantly between refractive groups (P = 0.91). Melatonin levels were not significantly correlated with SER, axial length, sleep, or activity scores (Spearman's rank, all P > 0.39). Higher levels of physical activity were associated with higher sleep quality (Spearman's rank, ρ = -0.28, P = 0.02).

Conclusion: The present study found no significant relationship between morning salivary melatonin levels and refractive error or axial length in young adolescents. This contrasts with outcomes from a previous study of adults with comparable methodology, season of data collection, and geographical location. Prospective studies are needed to understand the discrepancies between adult and childhood findings and evaluate whether melatonin levels in childhood are indicative of an increased risk for future onset of myopia and/or faster axial growth trajectories and myopia progression in established myopes. Future work should opt for a comprehensive dim-light melatonin onset protocol to determine circadian phase.

目的:先前的研究表明,年轻成人近视患者的褪黑激素状态与屈光不正和轴长之间存在关联。这项研究旨在确定这种关系是否延伸到更年轻的青少年群体。方法:12-15岁的健康儿童 years在就读阿尔斯特大学(55°N)之前提供了早上的唾液样本,用于自行屈肌麻痹和轴向长度测量。参与者完成了描述近期睡眠习惯和体育活动的问卷调查。唾液褪黑激素采用高效液相色谱-串联质谱法进行定量。所有参与者的数据收集时间为1周(2021年4月)。结果:70名年龄为14.3(95%CI:14.2-14.5)岁的参与者根据球面等效折射率[SER](范围:-5.38DS至+1.88DS)分为两组;近视SER ≤ -0.50DS(n = 22)或非瞳孔-0.50DS n = 48)。早晨唾液褪黑激素水平中位数为4.52 pg/ml(95%可信区间:2.60-6.02)和4.89 pg/ml(95%可信区间:3.18-5.66),屈光组间差异无统计学意义(P = 褪黑激素水平与SER、轴长、睡眠或活动评分无显著相关性(Spearman等级,均P > 0.39)。较高的体力活动水平与较高的睡眠质量有关(Spearman秩,ρ = -0.28,P = 0.02)。结论:本研究发现青少年晨间唾液褪黑素水平与屈光不正或轴长之间没有显著关系。这与之前一项针对成年人的研究结果形成了对比,该研究采用了可比的方法、数据收集季节和地理位置。需要进行前瞻性研究,以了解成人和儿童研究结果之间的差异,并评估儿童时期的褪黑素水平是否预示着近视患者未来发病风险的增加和/或更快的轴向生长轨迹和近视进展。未来的工作应该选择一个全面的微光褪黑激素发作方案来确定昼夜节律。
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引用次数: 0
Neuro-opthalmological aspect of Tolosa-Hunt Syndrome: A Case Report Tolosa-Hunt综合征的神经眼科方面:1例报告
4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-11-01 DOI: 10.31288/oftalmolzh202355355
Віра Васюта, О. П. Вітовська, Т. А. Йовенко, С. А. Вербовська, Л.О. Дунаєвська
Tolosa-Hunt Syndrome is an idiopathic granulomatous inflammatory disease of the cavernous sinus, superior orbital fissure, or orbit which is manifested by ocular pain and ophthalmoplegia. Granulomatous inflammation of the dural wall of the cavernous sinus and/or superior orbital fissure is the basis of the pathological process. The disease is clinically manifested by orbital pain, diplopia, exophthalmos, and/or oculomotor abnormalities. The syndrome is also called painful ophthalmoplegia with a key symptom being neuropathic periorbital or retro-orbital pain, and paresthesias along the first branch of the trigeminal nerve. We present a case of this syndrome. The patient was administered hormonal therapy, Medrol at a daily dose of 1 mg/kg body weight/day intravenously for five days, with subsequent transition within a month to oral Medrol. The pain in the eye completely relieved and restoration of normal ocular motility was observed in the presence of hormonal therapy. Tolosa-Hunt syndrome is a clinical diagnosis of exclusion (i.e., it is diagnosed after excluding other causes of painful ophthalmoplegia).
Tolosa-Hunt综合征是一种特发性肉芽肿性炎症性疾病,发生于海绵状窦、眶上裂或眶内,表现为眼痛和眼麻痹。海绵窦硬膜壁和/或眶上裂的肉芽肿性炎症是病理过程的基础。临床表现为眼窝疼痛、复视、眼球突出和/或动眼力异常。该综合征又称疼痛性眼麻痹,主要症状为神经性眶周或眶后疼痛,三叉神经第一支感觉异常。我们报告一例这种综合征。患者给予激素治疗,每日剂量为1mg /kg体重/天,静脉注射,持续5天,随后在一个月内转为口服。在激素治疗下,眼睛疼痛完全缓解,眼球运动恢复正常。Tolosa-Hunt综合征是一种排除性的临床诊断(即在排除了疼痛性眼麻痹的其他原因后诊断)。
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引用次数: 0
Preoperative visual function characteristics having an effect on the success of exotropia surgery 术前视功能特征对外斜视手术成功的影响
4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-11-01 DOI: 10.31288/oftalmolzh202351621
Ірина Бойчук, Алуі Тарак
Background: There are individual reports on the effect of some preoperative characteristics of visual functions (like convergence, angle of deviation, presence of fusion and type of binocular vision) on the success of exotropia surgery. To date, however, it has not been established what are the major diagnosis-related prognostic factors for the success of surgery for exotropia. Purpose: To identify the preoperative characteristics of visual functions which have an effect on the success of surgery for exotropia. Material and Methods: Of the 59 exotropes (age range, 10 to 21 years) included in this study, 33 had basic constant exotropia (group 1) and 26, intermittent exotropia (group 2). Patients underwent an ophthalmological and ortoptic examination of the motor and sensory systems of the eye. Patients with surgery success (postoperative orthotropes) were compared to those who had a residual exotropia of more than 10 prism diopters (PD) postoperatively in terms of the preoperative accommodative convergence–accommodation (AC/A) ratio, near point of convergence (NPC), distance stereopsis and near stereoacuity threshold. Results: Our analysis of the preoperative NPC, AC/A ratio and stereopsis for the group with postoperative orthotropic alignment and the group with postoperative exotropic alignment found preoperative close to normal values of AC/A ratio (4.0 ± 1.65 PD/D), NPC (8.03 ± 3.02 cm), the presence of distance stereopsis and near stereopsis (passing the 200 second of arc image on the Lang II stereo card) and the absence of medial rectus hypofunction of hyperfunction in 83.05% of patients of the former group. Conclusion: Preoperative close to normal values of AC/A ratio (4.0 ± 1.65 PD/D), NPC (8.03 ± 3.02 cm), the presence of distance stereopsis and near stereopsis (passing the 200 second of arc image on the Lang II stereo card) and the absence of medial rectus hypofunction of hyperfunction can be the factors favoring the success of exotropia surgery.
背景:一些术前视功能特征(如会聚、偏角、有无融合和双眼视觉类型)对外斜视手术成功的影响有个别报道。然而,迄今为止,还没有确定外斜视手术成功的主要诊断相关预后因素是什么。目的:探讨影响外斜视手术成功的术前视功能特点。材料和方法:在本研究纳入的59例外斜视患者(年龄范围10 - 21岁)中,33例为基本恒定外斜视(1组),26例为间歇性外斜视(2组)。患者接受了眼部运动和感觉系统的眼科和矫正检查。将手术成功的患者(术后正位斜视)与术后残余外斜视超过10棱镜屈光度(PD)的患者在术前调节会聚-调节(AC/ a)比、近会聚点(NPC)、距离立体视和近立体视阈值方面进行比较。结果:我们分析了术后各向异性对齐组和术后外向性对齐组术前鼻部、AC/A比和立体视,发现术前AC/A比(4.0±1.65 PD/D)接近正常值,鼻部(8.03±3.02 cm)接近正常值,存在距离立体视和近立体视(在Lang II立体卡上通过200秒弧线图像),83.05%的患者未出现内直肌功能减退或功能过度。结论:术前AC/A比值(4.0±1.65 PD/D)接近正常值,NPC(8.03±3.02 cm),有无远距离立体视和近距离立体视(Lang II立体显像通过200秒弧线),无内直肌功能减退或功能过度是外斜视手术成功的因素。
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引用次数: 0
Evaluation of Fundus Function in Mature Cataract Patients by Visual Electrophysiology. 视觉电生理对成熟白内障患者眼底功能的评价。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9065094
Min Zhang, Min Ji, Mengjia Tan, Ying Yu, Huaijin Guan

Purpose: To explore the value of visual electrophysiology in evaluating the fundus function of mature cataract patients.

Methods: 124 mature cataract patients (153 eyes) were examined before cataract surgery; the examinations included best corrected visual acuity (BCVA), pattern visual evoked potential (PVEP), full-field electroretinogram (ffERG), and multifocal electroretinogram (mfERG). According to the postoperative fundus conditions, the subjects were divided into two groups: the no fundus disease group and the fundus disease group. Approximately one month after the operation, BCVA was measured, and visual electrophysiology was performed on subjects who had a stable fundus condition and had not received treatment for fundus disease.

Results: One month after cataract surgery, BCVA ≤ 0.3 logMAR was found in 60 eyes (96.8%) without fundus disease and 59 eyes (64.8%) with fundus disease. Compared with the group without fundus disease, the preoperative electrophysiological examination of the group with fundus disease showed that the amplitude of ffERG waves and the amplitude density of the P1 wave in the 2nd to 5th rings of mfERG were decreased (all P < 0.05). ffERG and mfERG can be used for differential diagnosis of fundus disease (all P < 0.05), while PVEP has no significant diagnostic value for fundus disease (all P > 0.05). In the group without fundus disease, the amplitude of the PVEP 15' P100 wave and the amplitude of dark-adapted (DA) 0.01 b-wave, DA 3.0 a-wave, and DA 10.0 a-wave were negatively correlated with postoperative logMAR BCVA (all P < 0.05). In the group with fundus disease, the amplitude of PVEP and ffERG and the amplitude density of mfERG were negatively correlated with postoperative logMAR BCVA (all P < 0.05). In the eyes of cortical cataracts, some parameters of PVEP, ffERG, and mfERG were significantly different before and after surgery. In the eyes of nuclear cataracts, some parameters of ffERG and mfERG were significantly different before and after surgery. In the eyes of posterior subcapsular cataracts, some parameters of PVEP and ffERG were significantly different before and after surgery.

Conclusions: ffERG and mfERG can be used to detect fundus disease in mature cataract patients. The preoperative visual electrophysiological examination has high clinical value in predicting postoperative vision of mature cataract patients with fundus disease. Different types of cataracts have different effects on electrophysiological examination results. When interpreting the electrophysiological report, it is necessary to consider the existence of cataracts. This trial is registered with 2019-K068.

目的:探讨视觉电生理在评价成熟白内障患者眼底功能中的价值。方法:对124例(153眼)成熟期白内障患者进行白内障术前检查;检查包括最佳矫正视力(BCVA)、模式视觉诱发电位(PVEP)、全视野视网膜电图(ffERG)和多焦视网膜电图(mfERG)。根据术后眼底情况,将受试者分为两组:无眼底病组和眼底病组。术后约一个月,测量BCVA,并对眼底状况稳定且未接受眼底病治疗的受试者进行视觉电生理检查。结果:白内障手术后一个月,BCVA ≤ 在60眼(96.8%)无眼底病和59眼(64.8%)有眼底病的患者中发现0.3logMAR。与无眼底病组相比,有眼底病组术前电生理检查显示mfERG第2~5环的ffERG波幅和P1波幅密度均下降(P P P > 无眼底病变组PVEP 15’P100波振幅、暗适应(DA)0.01 b波、DA 3.0 a波、DA 10.0 a波振幅与术后logMAR BCVA呈负相关(均P P 结论:ffERG和mfERG可用于检测成熟白内障患者的眼底病变。术前视觉电生理检查对预测患有眼底病的成熟白内障患者术后视力具有较高的临床价值。不同类型的白内障对电生理检查结果的影响不同。在解释电生理报告时,有必要考虑白内障的存在。本次试验注册号为2019-K068。
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引用次数: 0
Glaucoma Characteristics and Influencing Factors during the COVID-19 Pandemic in the Huizhou Region. 新冠肺炎疫情期间惠州地区青光眼的特点及影响因素。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-10-26 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8889754
Huilan Zhou, Rui Liao, Dongxuan Zhang, Wei Wang, Shuifeng Deng

Objective: Glaucoma in individuals who tested positive for the coronavirus disease 2019 (COVID-19) during the pandemic outbreak has not been comprehensively studied. Therefore, this study aimed to analyze the characteristics and risk factors of glaucoma during the COVID-19 pandemic in Huizhou.

Methods: Retrospective data from outpatients with glaucoma at the Huizhou Hospital Affiliated with Guangzhou Medical University and Longmen County People's Hospital were collected during two periods: the COVID-19 pandemic period (Phase A: December 1, 2022, to January 19, 2023) and the prevention and control period (Phase B: December 1, 2021, to January 19, 2022). The demographic characteristics of the outpatients during both phases were compared. The characteristics of glaucoma in patients with COVID-19 during Phase A were examined. Multivariate logistic regression analysis was used to identify factors influencing the development of acute angle-closure glaucoma (AACG) in Phase A patients.

Results: The proportion of patients with glaucoma was significantly higher during Phase A than during Phase B at both hospitals. No statistically significant differences were observed between patients with glaucoma during Phases A and B for age, sex, and region. A high COVID-19-positive rate was associated with old age, females, AACG, newly diagnosed glaucoma, and binocular involvement during phase A. Females testing positive for COVID-19, glaucoma that started after testing positive for COVID-19, and a history of medication use were associated with a higher proportion of AACG in phase A. Multivariable logistic regression analysis identified testing positive for COVID-19 as an independent potential risk factor for developing AACG.

Conclusion: In summary, during the COVID-19 pandemic in Huizhou, patients with COVID-19 were primarily affected by AACG, especially females, older individuals, and those with binocular involvement. Testing positive for COVID-19 increases the risk of developing AACG.

目的:尚未对大流行期间2019冠状病毒病(新冠肺炎)检测呈阳性的人的青光眼进行全面研究。因此方法:回顾性收集广州医科大学附属惠州医院和龙门县人民医院在新冠肺炎流行期间(A期:2022年12月1日至2023年1月19日)门诊青光眼患者资料防控期(B期:2021年12月1日至2022年1月19日)。比较两个阶段门诊患者的人口统计学特征。研究了新冠肺炎患者A期青光眼的特点。采用多变量逻辑回归分析来确定影响A期患者急性闭角型青光眼(AACG)发展的因素。结果:两所医院的青光眼患者在A期的比例均显著高于B期。A期和B期青光眼患者在年龄、性别和地区方面没有观察到统计学上的显著差异。高COVID-19阳性率与老年人、女性、AACG、新诊断的青光眼和A期双眼受累有关。COVID-19]检测呈阳性的女性、新冠肺炎检测呈阳性后开始的青光眼和药物使用史与A期AACG比例较高相关。多因素逻辑回归分析确定新冠肺炎检测呈阳性是发展AACG的一个独立的潜在风险因素。结论:总之,在惠州新冠肺炎大流行期间,新冠肺炎患者主要受AACG的影响,尤其是女性、老年人和双目受累患者。新冠肺炎检测呈阳性会增加患AACG的风险。
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引用次数: 0
Inhaled Corticosteroid Exposure and Risk of Cataract in Patients with Asthma and COPD: A Systematic Review and Meta-Analysis. 哮喘和慢性阻塞性肺病患者吸入皮质类固醇暴露与白内障风险:系统综述和荟萃分析。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-10-19 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8209978
Osman Savran, Charlotte Suppli Ulrik

Purpose: Both systemic and inhaled corticosteroids may increase the risk of cataract in patients with both chronic obstructive pulmonary disease (COPD) and asthma. Our aim was to assess the degree of association between cataract and corticosteroid exposure in patients with asthma and COPD.

Methods: A systematic literature review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. The odds ratio estimates were extracted from each article. A random effects model was applied for estimate pooling in separate meta-analyses according to study design. Meta-regression was performed to assess the dose-response relationship between corticosteroid exposure and the risk of cataract development.

Results: A total of 19 studies met the criteria for inclusion in this review, of which 12 studies provided effect estimates for pooled analyses. All but one of the included observational studies reported a significant association between use of corticosteroids and cataract development in cohorts of asthma and/or COPD patients. Pooled analyses revealed on average a doubled risk of cataract in corticosteroid-exposed asthma and COPD patients. Studies have shown that daily high-dose inhaled corticosteroid (ICS) ≥ 1000 μg is associated with a significant risk of developing cataract and by that predispose to subsequent cataract surgery, although one study showed that systemic corticosteroids increase cataract risk more than ICS.

Conclusion: ICS treatment in asthma and COPD patients is a risk factor for cataract development. Our results emphasize a previously underestimated potential long-term risk of treatment with ICS and underline the importance of targeting ICS treatment, and not least dosing, to improve the risk-benefit ratio of maintenance treatment in both asthma and COPD.

目的:全身和吸入皮质类固醇都可能增加慢性阻塞性肺病(COPD)和哮喘患者患白内障的风险。我们的目的是评估哮喘和COPD患者白内障和皮质类固醇暴露之间的关联程度。方法:根据系统评价和荟萃分析指南的首选报告项目进行系统文献综述和荟萃分析。从每篇文章中提取比值比估计值。根据研究设计,将随机效应模型应用于单独的荟萃分析中的估计池。采用荟萃回归法评估皮质类固醇暴露与白内障发生风险之间的剂量-反应关系。结果:共有19项研究符合纳入本综述的标准,其中12项研究提供了汇总分析的效果估计。除一项外,所有纳入的观察性研究都报告了哮喘和/或COPD患者队列中皮质类固醇的使用与白内障发展之间的显著关联。汇总分析显示,暴露于皮质类固醇的哮喘和COPD患者患白内障的风险平均增加了一倍。研究表明,每天高剂量吸入皮质类固醇(ICS) ≥ 1000 μg与患白内障的显著风险相关,从而易患后续白内障手术,尽管一项研究表明,全身皮质类固醇比ICS更能增加白内障风险。结论:哮喘和COPD患者的ICS治疗是白内障发生的危险因素。我们的研究结果强调了先前低估的ICS治疗的潜在长期风险,并强调了靶向ICS治疗的重要性,尤其是给药,以提高哮喘和COPD维持治疗的风险效益比。
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引用次数: 0
Optical Coherence Tomography Angiography for Evaluation of Conjunctival Vessels in Dry Eyes. 光学相干断层扫描血管造影术用于评估干眼结膜血管。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-10-14 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1609332
TongFeng Cui, HongYan Sun, ZiZhong Hu, YaBo Shi, Jiang Zhu, ManMan Jin, Bing Qin

Objective: This study aimed to evaluate conjunctival vessels in patients with dry eye disease (DED) using optical coherence tomography angiography (OCTA).

Methods: This was a cross-sectional, observational clinical study. Twenty-three eyes of 18 patients with DED and 28 eyes of 23 healthy controls were included for examination in this study. The evaluation included the application of an Ocular Surface Disease Index Questionnaire, Schirmer Basic Secretion Test, and anterior OCTA targeting the temporal conjunctiva. AngioTool software was used to quantify the total vessel length and vessel density in the 3 × 3 mm temporal region of interest.

Results: Blood vessel density measurements were compared across the OCTA systems. The total vessel length within the conjunctiva of the DED group (4799.34 ± 834.36) exceeded that of the control eye (3864.89 ± 1455.70) group (P < 0.05). However, the difference in vessel density between the two groups was not statistically significant.

Conclusion: Measurement and analysis of conjunctival blood vessels using OCTA exhibited robust repeatability. In dry eyes, the total number of conjunctival blood vessels increased in accordance with disease severity. Hypoxia of conjunctival tissue may be an important cause of dry eye disease.

目的:本研究旨在利用光学相干断层扫描血管造影术(OCTA)评估干眼病(DED)患者的结膜血管。方法:这是一项横断面观察性临床研究。本研究包括18名DED患者的23只眼睛和23名健康对照的28只眼睛进行检查。评估包括应用眼表疾病指数问卷、Schirmer基础分泌物测试和针对颞结膜的前OCTA。AngioTool软件用于量化3 × 3. mm感兴趣的时间区域。结果:比较了OCTA系统的血管密度测量结果。DED组结膜内的总血管长度(4799.34 ± 834.36)超过对照眼(3864.89 ± 1455.70)组(P 结论:OCTA对结膜血管的测量和分析具有较强的重复性。在干眼症中,结膜血管的总数随着疾病的严重程度而增加。结膜组织缺氧可能是干眼症的一个重要原因。
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引用次数: 0
Changes in Stress-Strain Index in School-Aged Children: A 3-Year Longitudinal Study. 学龄儿童应力应变指数的变化:一项为期3年的纵向研究。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-10-14 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6680748
Zhengfei Yang, Bo Wu, Zhouyue Li, Mengting Yu, Jinyun Jiang, Shuyuan Chen, Shengsong Xu, Junwen Zeng, Mengyi Wang, Xiao Yang

Purpose: To determine three-year change of the corneal biomechanical parameter stress-strain index (SSI) in schoolchildren aged 7- 9 years and their correlation with refractive error and axial length (AL).

Methods: This is a prospective cohort study. Data of the AL, refractive error, and corneal biomechanical parameter SSI were collected at baseline and a 3-year follow-up for 217 schoolchildren. SSI, AL, and refractive error were measured via corneal visualization Scheimpflug technology (Corvis ST), IOLMaster biometry, and cycloplegic refraction. Three years of changes in SSI and its association with refractive error and AL were analyzed. Participants were divided into persistent nonmyopia (PNM), newly developed myopia (NDM), and persistent myopia (PM). The three-year difference in SSI among the three groups was analyzed.

Results: After three years of follow-up, the corneal biomechanical parameter SSI decreased in all participants (P < 0.01). There was a negative correlation between the change in SSI and the change in AL (r = -0.205, P=0.002) and a positive correlation between the change in refractive error (r = 0.183, P=0.007). After three years of follow-up, there was a decrease in the SSI for the NDM, PM, and PNM participants, with a median change of -0.05 for PNM and -0.13 and -0.09 for the NDM and PM, respectively. There was a significant decrease in corneal biomechanical properties for NDM patients compared with PNM patients (P < 0.01).

Conclusion: In 7- to 9-year-old schoolchildren, SSI decreased after three years of the longitudinal study, and the change in SSI was correlated with the change in AL and refractive error. There was a rapid decrease in corneal biomechanical properties among newly developed myopic patients.

目的:测定7-9岁学龄儿童角膜生物力学参数应力应变指数(SSI)的三年变化 年及其与屈光误差和轴向长度(AL)的相关性。方法:这是一项前瞻性队列研究。在基线和217名学童的3年随访中收集AL、屈光不正和角膜生物力学参数SSI的数据。SSI、AL和屈光不正通过角膜可视化Scheimpflug技术(Corvis ST)、IOLMaster生物测量和睫状肌麻痹屈光度进行测量。分析了三年来SSI的变化及其与屈光不正和AL的关系。参与者被分为持续性非近视(PNM)、新发近视(NDM)和持续性近视(PM)。分析三组SSI的三年差异。结果:随访3年后,所有受试者角膜生物力学参数SSI均下降(P<0.01),SSI的变化与AL的变化呈负相关(r = -0.205,P=0.002)与折射误差的变化之间的正相关性(r = 0.183,P=0.007)。经过三年的随访,NDM、PM和PNM参与者的SSI有所下降,PNM的中位数变化分别为-0.05和-0.13和-0.09。与PNM患者相比,NDM患者的角膜生物力学特性显著降低(P<0.01)。结论:在7-9岁的学童中,经过三年的纵向研究,SSI降低,SSI的变化与AL和屈光不正的变化相关。在新发展的近视患者中,角膜生物力学特性迅速下降。
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引用次数: 0
Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus. 角膜和上皮厚度图参数检测角膜和疑似角膜的诊断准确性。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-10-06 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6677932
Abdelrahman Salman, Cosimo Mazzotta, Obeda Kailani, Marwan Ghabra, Rana Omran, Ashraf Armia Balamoun, Taym Darwish, Rafea Shaaban, Hala Alhaji

Aim: To establish the diagnostic accuracy of corneal and epithelial thickness measurements obtained by spectral-domain optical coherence tomography (SD-OCT) in detecting keratoconus (KC) and suspect keratoconus (SKC).

Methods: This retrospective study reviewed the data of 144 eyes separated into three groups by the Sirius automated corneal classification software: normal (N) (n = 65), SKC (n = 43), and KC (n = 36). Corneal thickness (CT) and epithelial thickness (ET) in the central (0-2 mm) and paracentral (2-5 mm) zones were obtained with the Cirrus high-definition OCT. Areas under the curve (AUC) of receiver operator characteristic (ROC) curves were compared across groups to estimate their discrimination capacity.

Results: ROC curve analysis revealed excellent predictive ability for ET variables: minimum (Min) ET (0_2), minimum-maximum (Min-Max) ET (0_2), superonasal-inferotemporal (SN-IT) ET (2_5), Min-Max ET (2_5), and Min ET (2_5) to detect keratoconus (AUC > 0.9, all). Min-Max CT (0_2) was the only CT parameter with excellent ability to discriminate between KC and N eyes (AUC = 0.94; cutoff = ≤-32 μm). However, both ET and CT variables were not strong enough (AUC < 0.8, all) to differentiate between SKC and N eyes, with the highest diagnostic power for Min-Max ET (2_5) (AUC = 0.71; cutoff = ≤-9 μm) and central corneal thickness (CCT) (AUC = 0.76; cutoff = ≤533 μm).

Conclusion: These results demonstrate that OCT-derived CT and ET are able to differentiate between KC and N eyes, with a high level of certainty. However, Min-Max ET (2_5) was the parameter with the highest ability to detect suspect keratoconus.

目的:建立光谱域光学相干断层扫描(SD-OCT)角膜和上皮厚度测量对圆锥角膜(KC)和可疑圆锥角膜(SKC)的诊断准确性 = 65),SKC(n = 43)和KC(n = 36)。角膜厚度(CT)和中央上皮厚度(ET)(0-2 mm)和中央旁(2-5 mm)区域。将受试者-操作者特征(ROC)曲线的曲线下面积(AUC)在各组之间进行比较,以估计其辨别能力。结果:ROC曲线分析显示,ET变量具有良好的预测能力:最小(Min)ET(0_2)、最小-最大(Min-Max > 0.9)。最小最大CT(0_2)是唯一一个具有良好区分KC和N眼能力的CT参数(AUC = 0.94;切断 = ≤-32 μm)。然而,ET和CT变量都不够强(AUC μm)和中央角膜厚度(CCT)(AUC) = 0.76;切断 = ≤533 μm)。结论:这些结果表明OCT衍生的CT和ET能够以高水平的确定性区分KC和N眼。然而,最小-最大ET(2_5)是检测可疑圆锥角膜能力最高的参数。
{"title":"Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus.","authors":"Abdelrahman Salman,&nbsp;Cosimo Mazzotta,&nbsp;Obeda Kailani,&nbsp;Marwan Ghabra,&nbsp;Rana Omran,&nbsp;Ashraf Armia Balamoun,&nbsp;Taym Darwish,&nbsp;Rafea Shaaban,&nbsp;Hala Alhaji","doi":"10.1155/2023/6677932","DOIUrl":"10.1155/2023/6677932","url":null,"abstract":"<p><strong>Aim: </strong>To establish the diagnostic accuracy of corneal and epithelial thickness measurements obtained by spectral-domain optical coherence tomography (SD-OCT) in detecting keratoconus (KC) and suspect keratoconus (SKC).</p><p><strong>Methods: </strong>This retrospective study reviewed the data of 144 eyes separated into three groups by the Sirius automated corneal classification software: normal (N) (<i>n</i> = 65), SKC (<i>n</i> = 43), and KC (<i>n</i> = 36). Corneal thickness (CT) and epithelial thickness (ET) in the central (0-2 mm) and paracentral (2-5 mm) zones were obtained with the Cirrus high-definition OCT. Areas under the curve (AUC) of receiver operator characteristic (ROC) curves were compared across groups to estimate their discrimination capacity.</p><p><strong>Results: </strong>ROC curve analysis revealed excellent predictive ability for ET variables: minimum (Min) ET (0_2), minimum-maximum (Min-Max) ET (0_2), superonasal-inferotemporal (SN-IT) ET (2_5), Min-Max ET (2_5), and Min ET (2_5) to detect keratoconus (AUC > 0.9, all). Min-Max CT (0_2) was the only CT parameter with excellent ability to discriminate between KC and N eyes (AUC = 0.94; cutoff = ≤-32 <i>μ</i>m). However, both ET and CT variables were not strong enough (AUC < 0.8, all) to differentiate between SKC and N eyes, with the highest diagnostic power for Min-Max ET (2_5) (AUC = 0.71; cutoff = ≤-9 <i>μ</i>m) and central corneal thickness (CCT) (AUC = 0.76; cutoff = ≤533 <i>μ</i>m).</p><p><strong>Conclusion: </strong>These results demonstrate that OCT-derived CT and ET are able to differentiate between KC and N eyes, with a high level of certainty. However, Min-Max ET (2_5) was the parameter with the highest ability to detect suspect keratoconus.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2023 ","pages":"6677932"},"PeriodicalIF":1.9,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiological Factors and Visual Outcomes of Dense Vitreous Hemorrhage in Patients Aged 80 years and above over the Past Decade in a Tertiary General Hospital. 80岁患者致密性玻璃体出血的病因因素和视觉结果 在过去的十年里,在一家三级综合医院工作了几年及以上。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2023-09-28 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8851207
Yuhua Ding, Bangtao Yao, Hui Ye, Fei Wang

This study aimed to investigate the main etiological factors and visual outcomes in patients with dense vitreous hemorrhage (DVH) aged ≥80 years. We retrospectively included patients with DVH aged ≥80 years who were admitted to our ophthalmology department between January 1, 2010, and December 31, 2019. All patients underwent pars plana vitrectomy (PPV). Data regarding demographic characteristics; preoperative and postoperative best-corrected visual acuity (BCVA), intraocular pressure (IOP), and ophthalmic B-scan ultrasonography findings; intraoperative conditions; and postoperative complications were collected and analyzed. A total of 44 patients (44 eyes) were enrolled, with a median age of 82 years; among them, 25 patients (56.82%) were men. The median preoperative BCVA was 2.3 (1.1-3.0). The main etiological factors included retinal vein occlusion (RVO) (20 eyes, 45.45%), polypoidal choroidal vasculopathy (PCV) (15 eyes, 34.09%), proliferative diabetic retinopathy (PDR) (7 eyes, 15.90%), retinal arterial macroaneurysm (RAM) (1 eye, 2.27%), and posterior vitreous detachment (PVD) (1 eye, 2.27%). The median final BCVA was 1.92 (0.5-2.6). There was a significant postoperative improvement in the BCVA; moreover, branch RVO (BRVO) had a better postoperative visual prognosis than central RVO (CRVO), PCV, and PDR (P < 0.05). The final postoperative BCVA was significantly better when the initial BCVA was above hand motion (HM) than when it was HM or lower (P < 0.05). Our findings indicate that RVO, PCV, and PDR were the main causes of DVH. Microinvasive PPV is a safe and effective method that can clarify diagnosis and improve BCVA. Patients with BRVO and preoperative BCVA > HM may have a relatively good visual prognosis. For patients aged ≥80 years who have an appropriate general condition, PPV can be timely performed to treat DVH.

本研究旨在探讨年龄≥80岁的致密性玻璃体出血(DVH)患者的主要病因和视觉结果 年。我们回顾性纳入了年龄≥80岁的DVH患者 在2010年1月1日至2019年12月31日期间入住我们眼科的年。所有患者均接受了平坦部玻璃体切除术(PPV)。关于人口特征的数据;术前和术后最佳矫正视力(BCVA)、眼压(IOP)和眼科B超检查结果;术中条件;收集并分析术后并发症。共有44名患者(44眼)入选,中位年龄为82岁 年;其中男性25例(56.82%)。术前BCVA中位数为2.3(1.1-3.0)。主要病因包括视网膜静脉阻塞(RVO)(20眼,45.45%)、息肉状脉络膜血管病(PCV)(15眼,34.09%)、增殖性糖尿病视网膜病变(PDR)(7眼,15.90%)、视网膜动脉大动脉瘤(RAM)(1眼,2.27%),和后玻璃体脱离(PVD)(1眼,2.27%)。中位最终BCVA为1.92(0.5-2.6)。术后BCVA有显著改善;此外,分支RVO(BRVO)的术后视觉预后优于中心RVO(CRVO)、PCV和PDR(P P  HM可能具有相对良好的视觉预后。对于年龄≥80岁的患者 年,有适当的一般情况,可以及时进行PPV治疗DVH。
{"title":"Etiological Factors and Visual Outcomes of Dense Vitreous Hemorrhage in Patients Aged 80 years and above over the Past Decade in a Tertiary General Hospital.","authors":"Yuhua Ding,&nbsp;Bangtao Yao,&nbsp;Hui Ye,&nbsp;Fei Wang","doi":"10.1155/2023/8851207","DOIUrl":"10.1155/2023/8851207","url":null,"abstract":"<p><p>This study aimed to investigate the main etiological factors and visual outcomes in patients with dense vitreous hemorrhage (DVH) aged ≥80 years. We retrospectively included patients with DVH aged ≥80 years who were admitted to our ophthalmology department between January 1, 2010, and December 31, 2019. All patients underwent pars plana vitrectomy (PPV). Data regarding demographic characteristics; preoperative and postoperative best-corrected visual acuity (BCVA), intraocular pressure (IOP), and ophthalmic B-scan ultrasonography findings; intraoperative conditions; and postoperative complications were collected and analyzed. A total of 44 patients (44 eyes) were enrolled, with a median age of 82 years; among them, 25 patients (56.82%) were men. The median preoperative BCVA was 2.3 (1.1-3.0). The main etiological factors included retinal vein occlusion (RVO) (20 eyes, 45.45%), polypoidal choroidal vasculopathy (PCV) (15 eyes, 34.09%), proliferative diabetic retinopathy (PDR) (7 eyes, 15.90%), retinal arterial macroaneurysm (RAM) (1 eye, 2.27%), and posterior vitreous detachment (PVD) (1 eye, 2.27%). The median final BCVA was 1.92 (0.5-2.6). There was a significant postoperative improvement in the BCVA; moreover, branch RVO (BRVO) had a better postoperative visual prognosis than central RVO (CRVO), PCV, and PDR (<i>P</i> < 0.05). The final postoperative BCVA was significantly better when the initial BCVA was above hand motion (HM) than when it was HM or lower (<i>P</i> < 0.05). Our findings indicate that RVO, PCV, and PDR were the main causes of DVH. Microinvasive PPV is a safe and effective method that can clarify diagnosis and improve BCVA. Patients with BRVO and preoperative BCVA > HM may have a relatively good visual prognosis. For patients aged ≥80 years who have an appropriate general condition, PPV can be timely performed to treat DVH.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2023 ","pages":"8851207"},"PeriodicalIF":1.9,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Ophthalmology
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