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Effect of Vitreous Reflux after Intravitreal Aflibercept Injection for Macular Edema with Branch Retinal Vein Occlusion: A Real-World Study. 玻璃体内注射 Aflibercept 治疗视网膜静脉分支闭塞性黄斑水肿后玻璃体回流的影响:真实世界研究。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-06-25 DOI: 10.1155/2024/7645490
Tetsuya Muto,Masaaki Sakamoto,Shigeki Machida,Shinichiro Imaizumi,Tetsuju Sekiryu
PurposeThis study aimed to evaluate the therapeutic effect of vitreous reflux (VR) after intravitreal aflibercept injection (IVAI) for macular edema (ME) following naïve branch retinal vein occlusion (BRVO).MethodsEighty patients with ME following BRVO were divided into three groups according to the conjunctival bleb diameter after IVAI as follows: group A (no VR), group; B (<3 mm VR), and group C (>3 mm VR). Each patient received single IVAI. The treatment response was evaluated with the best-corrected visual acuity (BCVA) and optical coherence tomography measurements of the retinal foveal thickness (RFT) before treatment and 1 month after the first injection. RFT >375 μm was defined as recurrence and received additional IVAI. The recurrence rate of ME and total numbers of IVAI were investigated at 12 months.ResultsThe BCVA values at 1 month were 0.17 ± 0.29 in group A (n = 41), 0.18 ± 0.17 in group B (n = 18), and 0.19 ± 0.26 in group C (n = 21). The RFT at 1 month were 270 ± 45 μm in group A, 279 ± 24 μm in group B, and 290 ± 43 μm in group C, respectively. ME recurred in 29 out of 41 patients in group A, 15 out of 18 in group B, and 14 out of 21 in group C. The total numbers of IVAI were 2.50 ± 1.24 in group A, 2.59 ± 1.06 in group B, and 2.29 ± 1.27 in group C, respectively. In the above mentioned comparisons, no significant differences were found following an IVAI (P > 0.05).ConclusionsVR after IVAI did not affect the therapeutic effect in patients with ME following BRVO. Thus, we do not need to pay excess attention to VR in the case of IVAI.
目的 本研究旨在评估玻璃体回流(VR)在玻璃体内注射阿弗利百普(aflibercept)(IVAI)治疗新生视网膜分支静脉闭塞(BRVO)后黄斑水肿(ME)的疗效。方法 根据IVAI后结膜虹膜直径的不同,将80例BRVO后ME患者分为三组:A组(无VR)、B组(3 mm VR)。每名患者接受一次 IVAI。治疗前和首次注射后 1 个月,用最佳矫正视力(BCVA)和光学相干断层扫描测量视网膜眼窝厚度(RFT)来评估治疗反应。RFT >375 μm被定义为复发,并接受额外的IVAI治疗。结果 A组(41 人)1 个月后的 BCVA 值为 0.17 ± 0.29,B 组(18 人)为 0.18 ± 0.17,C 组(21 人)为 0.19 ± 0.26。1 个月时,A 组的 RFT 分别为 270 ± 45 μm,B 组为 279 ± 24 μm,C 组为 290 ± 43 μm。A组41名患者中有29人复发ME,B组18人中有15人复发ME,C组21人中有14人复发ME,IVAI总数分别为2.50±1.24(A组)、2.59±1.06(B组)和2.29±1.27(C组)。在上述比较中,IVAI 后无明显差异(P > 0.05)。因此,在进行 IVAI 时,我们无需过分关注 VR。
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引用次数: 0
Repeatability and Agreement of Central Vault for Implantable Collamer Lens Obtained by the Tomey OA-2000 Biometer and Spectralis OCT. 通过 Tomey OA-2000 Biometer 和 Spectralis OCT 获得的植入式准分子透镜中心穹窿的重复性和一致性。
IF 1.8 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3684626
Hao Wu, Zuocheng Wang, Pengfei Wang, Yifei Meng, Zengying Wang, Yuhong Xue, Bohua Jiang, Shuaixi Pan, Zhipeng Yan

Objective: To assess repeatability and agreement of central vault for implantable collamer lens (ICL) measured by the Tomey OA-2000 biometry and Spectralis optical coherence tomography (OCT).

Methods: In this prospective study, the central vault was measured by the Tomey OA-2000 biometer and Spectralis OCT in 84 eyes (43 patients) after ICL implantation at six month follow-up. Three consecutive scans were obtained by one experienced technician using Tomey OA-2000 and the Spectralis OCT in the same day. The coefficient of variation (CoV), intraclass correlation coefficient (ICC), within-subject standard deviation (Sw), and 2.77 Sw were calculated to assess the repeatability and reproducibility. The paired t-test and Bland-Altman plots were used to analyze the differences and agreements of central vault measured by two devices.

Results: Repeatability of the central vault measured by Tomey OA-2000 biometer and Spectralis OCT showed that the CoV was 2.71% and 1.66%, respectively. The ICC for both devices was 0.996 and 0.999, respectively. The paired t-test showed that central vault measured by Tomey OA-2000 biometer was -7.25 ± 23.57 microns lower than that measured by Spectralis OCT (P = 0.006). The mean difference between measurements for Tomey OA-2000 and ASM-OCT with 95% limits of agreement (LoAs) was -38.94 to 53.44 μm.

Conclusion: Both Tomey OA-2000 biometer and Spectralis OCT displayed good repeatability for the measurement of central vault of ICL. Good reliability and agreement were observed between Tomey OA-2000 biometer and Spectralis OCT. Both instruments are useful but not replaced each other for central vault measurements.

目的评估通过 Tomey OA-2000 生物测量仪和 Spectralis 光学相干断层扫描(OCT)测量的植入式有晶体眼(ICL)中央穹隆的重复性和一致性:在这项前瞻性研究中,使用Tomey OA-2000生物测量仪和Spectralis光学相干断层扫描测量了ICL植入术后六个月随访的84只眼睛(43名患者)的中央穹隆。由一名经验丰富的技术人员在同一天使用 Tomey OA-2000 和 Spectralis OCT 连续扫描三次。计算变异系数(CoV)、类内相关系数(ICC)、受试者内标准偏差(Sw)和 2.77 Sw,以评估重复性和再现性。采用配对 t 检验和 Bland-Altman 图分析两种仪器测量的中央穹隆的差异和一致性:结果:Tomey OA-2000 生物测量仪和 Spectralis OCT 测量的中央穹隆的重复性显示,CoV 分别为 2.71% 和 1.66%。两种设备的 ICC 分别为 0.996 和 0.999。配对 t 检验显示,Tomey OA-2000 生物测量仪测量的中心穹窿比 Spectralis OCT 测量的中心穹窿低 -7.25 ± 23.57 微米(P = 0.006)。Tomey OA-2000 和 ASM-OCT 测量值之间的平均差异(95% 的一致性限值)为 -38.94 至 53.44 微米:结论:Tomey OA-2000 生物测量仪和 Spectralis OCT 在测量 ICL 中央穹隆时均显示出良好的重复性。Tomey OA-2000 生物测量仪和 Spectralis OCT 之间具有良好的可靠性和一致性。这两种仪器在中心穹隆测量中都很有用,但不能相互替代。
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引用次数: 0
Demographics, Presenting Features, and Outcomes of Adult Patients with Ocular Trauma. 眼外伤成人患者的人口统计学特征、表现特征和治疗效果。
IF 1.8 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-06-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8871776
Leanne M Clevenger, Jessica L Cao, Megan S Steinkerchner, Amy S Nowacki, Alex Yuan

Introduction: Ocular trauma is a common cause of permanent vision loss in adults. The combination of an accurate clinical examination and imaging offers the best prognostic indicators for patients and helps to navigate treatment modalities. This is a retrospective chart review of examination and imaging findings for ocular trauma and how they correlate with treatment course and visual acuity (VA) outcomes.

Methods: Adult patients with ocular trauma presenting to a single institution between January 2013 and December 2020 were evaluated. Initial examination and imaging findings were compared for associations with each other and with VA outcomes.

Results: 136 ocular traumas on 134 patients were included. The median presenting logMAR VA was 2.7 (interquartile range (IQR) 1.2-3.7) with 62% open globe injuries. The most commonly reported finding on initial CT scan was globe deformity (30%), on B-scan was choroidal detachment (20%), and on ultrasound biomicroscopy was intraocular foreign body, ciliochoroidal effusions, or angle recession (21% each). Worse vision was observed for patients positive for retinal detachment on initial B-scan compared to those negative for this finding at 6-month (median logMAR 2.7 vs. 0.5; P < 0.0001) and at final post-injury evaluation (median logMAR 3.7 vs. 0.4; P < 0.0001). Similarly, worse VA was observed for patients with choroidal detachment on initial B-scan compared to those without this finding at 6-month (median logMAR 1.4 vs. 0.5; P = 0.002) and at final post-injury evaluation (median logMAR 2.0 vs. 0.4; P < 0.0001). If positive conjunctiva/sclera examination findings were identified, 66% had positive findings on B-scan, whereas if the conjunctiva/sclera examination findings were absent, 41% had positive findings on B-scan (P = 0.005). If anterior chamber (AC) examination findings were positive, 59% had positive findings on B-scan, whereas if the AC examination findings were absent, 37% had positive findings on B-scan (P = 0.03). Discussion. The predictive value of examination findings in this study may offer insight as to long-term visual prognosis. Positive B-scan or CT findings should increase suspicion for open globe injuries.

介绍:眼外伤是导致成人永久性视力丧失的常见原因。准确的临床检查和影像学检查相结合,可为患者提供最佳预后指标,并有助于确定治疗方法。这是对眼外伤检查和成像结果的回顾性病历回顾,以及这些结果与治疗过程和视力(VA)结果的相关性:方法:对 2013 年 1 月至 2020 年 12 月期间在一家医疗机构就诊的眼外伤成人患者进行评估。方法:对 2013 年 1 月至 2020 年 12 月期间在一家医疗机构就诊的眼外伤成人患者进行评估,比较初步检查和成像结果与 VA 结果之间的关联:结果:共纳入 134 名患者的 136 例眼外伤。出现的中位对数MAR VA为2.7(四分位距(IQR)为1.2-3.7),62%为开球伤。最初的 CT 扫描最常见的发现是眼球畸形(30%),B 型扫描是脉络膜脱离(20%),超声生物显微镜检查是眼内异物、纤毛膜积液或角膜后退(各占 21%)。在 6 个月和伤后最终评估中(中位数对数分辨力 2.7 对 0.5;P < 0.0001),观察到初次 B 扫描视网膜脱离阳性的患者视力比阴性患者差(中位数对数分辨力 3.7 对 0.4;P < 0.0001)。同样,与未发现脉络膜脱离的患者相比,初次 B 扫描发现脉络膜脱离的患者在 6 个月时的视力较差(中位数 logMAR 1.4 vs. 0.5;P = 0.002),在伤后最终评估时的视力也较差(中位数 logMAR 2.0 vs. 0.4;P < 0.0001)。如果发现结膜/巩膜检查结果呈阳性,66%的患者在 B 型扫描中发现阳性结果,而如果没有结膜/巩膜检查结果,41%的患者在 B 型扫描中发现阳性结果(P = 0.005)。如果前房(AC)检查结果呈阳性,则 59% 的人在 B 型扫描中获得阳性结果,而如果前房检查结果缺失,则 37% 的人在 B 型扫描中获得阳性结果(P = 0.03)。讨论。本研究中检查结果的预测价值可为长期视觉预后提供启示。B-扫描或CT阳性结果应增加对开球损伤的怀疑。
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引用次数: 0
Detecting Keratoconus in Adolescents with Anterior Segment Optical Coherence Tomography. 用前眼球光学相干断层扫描检测青少年角膜炎。
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-06-07 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6655217
Burcu Yücekul, Anika Förster, H Burkhard Dick, Suphi Taneri

Purpose: Assessing the applicability of an algorithm developed for keratoconus detection in adolescents. This algorithm relies on optical coherence tomography (OCT) and incorporates features related to corneal pachymetric and epithelial thickness alterations.

Methods: We retrospectively reviewed charts of patients under the age of 18 and divided them into four groups according to the Belin-Ambrosio display (Pentacam): normal, manifest, and subclinical keratoconus, as well as very asymmetric eye with normal topography and tomography (VAE-NTT). Corneal and epithelial thickness maps (Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Germany) were evaluated by a human grader. In the first step, if at least one of four parameters (pachymetry minimum (pachy min), pachy minimum-median (min-med), pachy superonasal-inferotemporal (SN-IT), or epithelial (epi SN-IT)) exceeded its cut-off value, the eye was considered as suspect. In the second step, the combined presence of coincident thinning of total cornea and epithelium as well as concentric epithelial thinning lead to the diagnosis of keratoconus. Receiver operating characteristic (ROC) curves were generated to determine area under the curve (AUC), sensitivity, and specificity for the parameters.

Results: The study involved 19 pediatric patients diagnosed with keratoconus, comprising 29 manifest keratoconic eyes, 3 eyes with subclinical keratoconus, and 5 VAE-NTT eyes. In addition, 22 eyes from 11 normal adolescents were included in the analysis. The AUC values of parameters in step 1 were 0.889 for pachy min, 0.997 for pachy min-med, 0.893 for pachy SN-IT, and 0.998 for epi SN-IT. When both steps were performed, this algorithm captured all manifest and subclinical pediatric keratoconic eyes. When all eyes of the keratoconus patients were combined, step 1 had 97.3% sensitivity and step 2 had 100% specificity.

Conclusion: Using this OCT-based approach in adolescents yielded a high level of agreement with the current gold standard, tomography. Using them together, potentially also with other examinations may improve the diagnostic accuracy of KC in the pediatric population. Integration of this approach into the software of the device to facilitate automated evaluations is desired.

目的:评估为检测青少年角膜病而开发的算法的适用性。该算法依赖于光学相干断层扫描(OCT),并结合了与角膜厚度和上皮厚度改变相关的特征:我们回顾性地查看了 18 岁以下患者的病历,并根据贝林-安布罗西奥(Belin-Ambrosio)显示法(Pentacam)将其分为四组:正常、明显和亚临床角膜炎,以及地形图和断层扫描正常的极不对称眼(VAE-NTT)。角膜和上皮厚度图(Cirrus 5000 HD-OCT,德国卡尔蔡司医疗技术公司)由人工分级师进行评估。第一步,如果四个参数(角膜厚度最小值 (pachy min)、角膜厚度最小值-中值 (min-med)、角膜厚度超基底层-干涉颞叶 (SN-IT) 或上皮 (epi SN-IT))中至少有一个参数超过临界值,则该眼被视为可疑。在第二步中,如果同时出现全角膜和上皮同时变薄以及同心上皮变薄,则可诊断为角膜炎。研究人员绘制了接收者操作特征曲线(ROC),以确定各参数的曲线下面积(AUC)、灵敏度和特异性:研究涉及 19 名被诊断为角膜炎的儿童患者,包括 29 只表现为角膜炎的眼睛、3 只亚临床角膜炎眼睛和 5 只 VAE-NTT 眼睛。此外,分析还包括 11 名正常青少年的 22 只眼睛。步骤 1 中参数的 AUC 值为:pachy min 0.889,pachy min-med 0.997,pachy SN-IT 0.893,epi SN-IT 0.998。当进行这两个步骤时,该算法捕获了所有显性和亚临床小儿角膜病变眼。如果将所有角膜炎患者的眼睛合并计算,步骤 1 的灵敏度为 97.3%,步骤 2 的特异性为 100%:结论:在青少年中使用这种基于光学视网膜成像的方法与目前的黄金标准--断层扫描--具有高度的一致性。将这两种方法结合使用,还可能与其他检查一起使用,可提高儿童 KC 诊断的准确性。希望能将这种方法整合到设备的软件中,以促进自动评估。
{"title":"Detecting Keratoconus in Adolescents with Anterior Segment Optical Coherence Tomography.","authors":"Burcu Yücekul, Anika Förster, H Burkhard Dick, Suphi Taneri","doi":"10.1155/2024/6655217","DOIUrl":"10.1155/2024/6655217","url":null,"abstract":"<p><strong>Purpose: </strong>Assessing the applicability of an algorithm developed for keratoconus detection in adolescents. This algorithm relies on optical coherence tomography (OCT) and incorporates features related to corneal pachymetric and epithelial thickness alterations.</p><p><strong>Methods: </strong>We retrospectively reviewed charts of patients under the age of 18 and divided them into four groups according to the Belin-Ambrosio display (Pentacam): normal, manifest, and subclinical keratoconus, as well as very asymmetric eye with normal topography and tomography (VAE-NTT). Corneal and epithelial thickness maps (Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Germany) were evaluated by a human grader. In the first step, if at least one of four parameters (pachymetry minimum (pachy min), pachy minimum-median (min-med), pachy superonasal-inferotemporal (SN-IT), or epithelial (epi SN-IT)) exceeded its cut-off value, the eye was considered as suspect. In the second step, the combined presence of coincident thinning of total cornea and epithelium as well as concentric epithelial thinning lead to the diagnosis of keratoconus. Receiver operating characteristic (ROC) curves were generated to determine area under the curve (AUC), sensitivity, and specificity for the parameters.</p><p><strong>Results: </strong>The study involved 19 pediatric patients diagnosed with keratoconus, comprising 29 manifest keratoconic eyes, 3 eyes with subclinical keratoconus, and 5 VAE-NTT eyes. In addition, 22 eyes from 11 normal adolescents were included in the analysis. The AUC values of parameters in step 1 were 0.889 for pachy min, 0.997 for pachy min-med, 0.893 for pachy SN-IT, and 0.998 for epi SN-IT. When both steps were performed, this algorithm captured all manifest and subclinical pediatric keratoconic eyes. When all eyes of the keratoconus patients were combined, step 1 had 97.3% sensitivity and step 2 had 100% specificity.</p><p><strong>Conclusion: </strong>Using this OCT-based approach in adolescents yielded a high level of agreement with the current gold standard, tomography. Using them together, potentially also with other examinations may improve the diagnostic accuracy of KC in the pediatric population. Integration of this approach into the software of the device to facilitate automated evaluations is desired.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"6655217"},"PeriodicalIF":1.9,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11178420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Study of Diabetic Retinopathy and Macular Edema in Southern Part of Bangladesh. 孟加拉国南部地区糖尿病视网膜病变和黄斑水肿的回顾性研究
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8437947
Md Asif Hasan, Sheikh Md Rabiul Islam, Md Arif Hayat Khan Pathan

Background: Diabetic mellitus is a vision-threatening disease because it causes diabetic retinopathy worldwide. The main focus of this research is to determine the prevalence and assess the visual outcome in diabetic retinopathy and macular edema patients by injecting Bevacizumab clinically.

Methods: This hospital-based trial case was conducted in Khulna BNSB Eye Hospital, Bangladesh. This study is based on a prospective cohort with a population of macular edema in 41 eyes of 25 diabetic patients, of whom 94 were diagnosed with diabetic retinopathy in 320 type 2 diabetes mellitus patients. The treating physician inserts 1.25 mg (0.05 ml) into the patient's eye. We have used optical coherence tomography (OCT) and colour fundus photography (CFP) for an eye check performed on all patients before and after the injection of Bevacizumab. The method results analyze the effects of the technique using IBM SPSS 25.

Results: The study population selected 25 patients with 41 eyes for clinical investigation by injection of Bevacizumab. The net effects of this study on five eyes with macular edema were entirely resolved. It was BCVA from 6/6 to 6/9. The 29 eyes were partially resolved, which is called improved visual acuity, and BCVA was 6/12 to 6/60. In the case of seven eyes, we found that the vision did not change before or after the Avastin injection. No change was seen in seven eyes of macular edema due to the effects of the Avastin injection before and after.

Conclusions: In clinical trial-based research, Bevacizumab (Avastin) is best effective for diabetic retinopathy (DR) and diabetic macular edema (DME) patients.

背景:糖尿病是一种威胁视力的疾病,因为它在全球范围内导致糖尿病视网膜病变。本研究的重点是通过临床注射贝伐珠单抗来确定糖尿病视网膜病变和黄斑水肿患者的患病率并评估其视觉效果:这项以医院为基础的试验在孟加拉国库尔纳 BNSB 眼科医院进行。这项研究是基于一项前瞻性队列研究,研究对象是 25 名糖尿病患者的 41 只眼睛出现黄斑水肿,其中 94 人被诊断为糖尿病视网膜病变,共有 320 名 2 型糖尿病患者。主治医生将 1.25 毫克(0.05 毫升)药物注入患者眼内。我们使用光学相干断层扫描(OCT)和彩色眼底照相术(CFP)对所有患者在注射贝伐珠单抗前后进行了眼部检查。该方法使用 IBM SPSS 25 分析了该技术的效果:研究对象选择了 25 名患者的 41 只眼睛进行注射贝伐珠单抗的临床检查。该研究对 5 只黄斑水肿眼的净疗效完全消除。BCVA 为 6/6 至 6/9。29只眼睛的黄斑水肿得到部分缓解,即视力得到改善,BCVA为6/12至6/60。有 7 只眼睛的视力在注射阿瓦斯汀前后没有变化。7只眼睛的黄斑水肿在注射阿瓦斯汀前后没有发生变化:在基于临床试验的研究中,贝伐单抗(阿瓦斯汀)对糖尿病视网膜病变(DR)和糖尿病黄斑水肿(DME)患者的疗效最佳。
{"title":"Retrospective Study of Diabetic Retinopathy and Macular Edema in Southern Part of Bangladesh.","authors":"Md Asif Hasan, Sheikh Md Rabiul Islam, Md Arif Hayat Khan Pathan","doi":"10.1155/2024/8437947","DOIUrl":"10.1155/2024/8437947","url":null,"abstract":"<p><strong>Background: </strong>Diabetic mellitus is a vision-threatening disease because it causes diabetic retinopathy worldwide. The main focus of this research is to determine the prevalence and assess the visual outcome in diabetic retinopathy and macular edema patients by injecting Bevacizumab clinically.</p><p><strong>Methods: </strong>This hospital-based trial case was conducted in Khulna BNSB Eye Hospital, Bangladesh. This study is based on a prospective cohort with a population of macular edema in 41 eyes of 25 diabetic patients, of whom 94 were diagnosed with diabetic retinopathy in 320 type 2 diabetes mellitus patients. The treating physician inserts 1.25 mg (0.05 ml) into the patient's eye. We have used optical coherence tomography (OCT) and colour fundus photography (CFP) for an eye check performed on all patients before and after the injection of Bevacizumab. The method results analyze the effects of the technique using IBM SPSS 25.</p><p><strong>Results: </strong>The study population selected 25 patients with 41 eyes for clinical investigation by injection of Bevacizumab. The net effects of this study on five eyes with macular edema were entirely resolved. It was BCVA from 6/6 to 6/9. The 29 eyes were partially resolved, which is called improved visual acuity, and BCVA was 6/12 to 6/60. In the case of seven eyes, we found that the vision did not change before or after the Avastin injection. No change was seen in seven eyes of macular edema due to the effects of the Avastin injection before and after.</p><p><strong>Conclusions: </strong>In clinical trial-based research, Bevacizumab (Avastin) is best effective for diabetic retinopathy (DR) and diabetic macular edema (DME) patients.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2024 ","pages":"8437947"},"PeriodicalIF":1.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11175843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Parameters and Nozzle Tip Damage after Clinical Use of Three Hydrophilic Intraocular Lens Injector Models 三种亲水性眼内透镜注射器临床使用后的参数和喷嘴尖端损坏评估
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-05-30 DOI: 10.1155/2024/2360368
Lu Zhang, Sonja Schickhardt, Patrick Merz, Gerd Uwe Auffarth
Purpose. To assess the nozzle tip damage and the parameters of three different hydrophilic intraocular lens (IOL) injector models. Methods. After routine cataract surgeries at the University Eye Hospital Heidelberg, all the used IOL injectors were collected from the operating room and sent to our laboratory. Nozzle tip damage was assessed under a microscope and graded as follows: no damage (grade 0), slight scratches (1), deep scratches (2), extensions (3), cracks (4), and bursts (5). Each damage grade was assigned a score from 0 to 5, and the total damage score for each injector system was calculated and compared. Nozzle tip parameters (diameters and areas), plunger tip parameters, and tip angles were also measured in each model. Results. The damage scores were (median, Q3-Q1): 1 (1-1) for Accuject, 1 (1-1) for Bluemixs, and 1 (1-1) for RayOne. There was no statistically significant difference in the damage scores between the study groups (). The outer cross-sectional vertical and horizontal diameters were 1.69 and 1.69 mm for Accuject, 1.69 and 1.69 mm for Bluemixs, and 1.70 and 1.71 mm for RayOne. Plunger tip areas were 0.78 mm2 for Accjuect, 0.74 mm2 for Bluemixs, and 0.43 mm2 for RayOne. Plunger tip area/inner cross-sectional area of the nozzle tip (%) was 31.2% for RayOne, 66.7% for Accuject, and 63.8% for Bluemixs. The tip angles for three injector models were 56° (Accuject), 56° (Bluemixs), and 44° (RayOne). Conclusions. All the injector models showed mild to moderate damage to the nozzle tip after IOL implantation, even with smaller diameter tips. RayOne resulted in the lowest ratio between plunger tip area and inner cross-sectional area of the nozzle tip and a better distribution of damage categories than the other two groups. All three injector models had relatively small tip parameters. If smaller incisions are required in certain patients, smaller tip parameters should be considered.
目的评估三种不同型号的亲水性眼内晶体(IOL)注射器的喷嘴尖端损坏情况和参数。方法。在海德堡大学眼科医院进行常规白内障手术后,从手术室收集所有使用过的人工晶体注射器,并将其送到我们的实验室。在显微镜下对喷嘴尖端的损坏情况进行评估,并将其分为以下等级:无损坏(0 级)、轻微划痕(1 级)、深度划痕(2 级)、延伸(3 级)、裂纹(4 级)和爆裂(5 级)。每个损坏等级的得分从 0 到 5 不等,然后计算每个喷射器系统的损坏总分并进行比较。还测量了每个模型的喷嘴尖端参数(直径和面积)、柱塞尖端参数和尖端角度。结果。损坏分数为(中位数,Q3-Q1):Accuject 为 1 (1-1),Bluemixs 为 1 (1-1),RayOne 为 1 (1-1)。各研究组之间的损伤评分差异无统计学意义()。Accuject 的外部横截面垂直和水平直径分别为 1.69 和 1.69 毫米,Bluemixs 为 1.69 和 1.69 毫米,RayOne 为 1.70 和 1.71 毫米。Accjuect 的柱塞头面积为 0.78 平方毫米,Bluemixs 为 0.74 平方毫米,RayOne 为 0.43 平方毫米。RayOne、Accuject 和 Bluemixs 的柱塞喷嘴顶端面积/喷嘴顶端内横截面积(%)分别为 31.2%、66.7% 和 63.8%。三种喷射器型号的喷嘴尖角分别为 56°(Accuject)、56°(Bluemixs)和 44°(RayOne)。结论。所有型号的注射器在植入人工晶体后都会对喷嘴尖端造成轻度到中度的损坏,即使是直径较小的喷嘴也是如此。与其他两组相比,RayOne 的柱塞尖端面积与喷嘴尖端内横截面积之比最小,损坏类别的分布也更好。所有三种喷射器型号的喷嘴参数都相对较小。如果某些患者需要较小的切口,则应考虑较小的喷嘴参数。
{"title":"Evaluation of Parameters and Nozzle Tip Damage after Clinical Use of Three Hydrophilic Intraocular Lens Injector Models","authors":"Lu Zhang, Sonja Schickhardt, Patrick Merz, Gerd Uwe Auffarth","doi":"10.1155/2024/2360368","DOIUrl":"https://doi.org/10.1155/2024/2360368","url":null,"abstract":"<i>Purpose</i>. To assess the nozzle tip damage and the parameters of three different hydrophilic intraocular lens (IOL) injector models. <i>Methods</i>. After routine cataract surgeries at the University Eye Hospital Heidelberg, all the used IOL injectors were collected from the operating room and sent to our laboratory. Nozzle tip damage was assessed under a microscope and graded as follows: no damage (grade 0), slight scratches (1), deep scratches (2), extensions (3), cracks (4), and bursts (5). Each damage grade was assigned a score from 0 to 5, and the total damage score for each injector system was calculated and compared. Nozzle tip parameters (diameters and areas), plunger tip parameters, and tip angles were also measured in each model. <i>Results</i>. The damage scores were (median, Q3-Q1): 1 (1-1) for Accuject, 1 (1-1) for Bluemixs, and 1 (1-1) for RayOne. There was no statistically significant difference in the damage scores between the study groups (<span><svg height=\"9.2729pt\" style=\"vertical-align:-0.6370001pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 19.289 9.2729\" width=\"19.289pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,11.658,0)\"></path></g></svg><span></span><span><svg height=\"9.2729pt\" style=\"vertical-align:-0.6370001pt\" version=\"1.1\" viewbox=\"22.8711838 -8.6359 21.918 9.2729\" width=\"21.918pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,22.921,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,29.161,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,32.125,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,38.365,0)\"></path></g></svg>).</span></span> The outer cross-sectional vertical and horizontal diameters were 1.69 and 1.69 mm for Accuject, 1.69 and 1.69 mm for Bluemixs, and 1.70 and 1.71 mm for RayOne. Plunger tip areas were 0.78 mm<sup>2</sup> for Accjuect, 0.74 mm<sup>2</sup> for Bluemixs, and 0.43 mm<sup>2</sup> for RayOne. Plunger tip area/inner cross-sectional area of the nozzle tip (%) was 31.2% for RayOne, 66.7% for Accuject, and 63.8% for Bluemixs. The tip angles for three injector models were 56° (Accuject), 56° (Bluemixs), and 44° (RayOne). <i>Conclusions</i>. All the injector models showed mild to moderate damage to the nozzle tip after IOL implantation, even with smaller diameter tips. RayOne resulted in the lowest ratio between plunger tip area and inner cross-sectional area of the nozzle tip and a better distribution of damage categories than the other two groups. All three injector models had relatively small tip parameters. If smaller incisions are required in certain patients, smaller tip parameters should be considered.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"47 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141196072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus 角膜体积与角膜生物力学之间的相关性以及角膜体积在角膜炎分期和诊断中的意义
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-05-29 DOI: 10.1155/2024/8422747
Zhiqing Wu, Yaohua Zhang, Yong Li, Fang Yang, Xirui Su, Yan Gao, Shengsheng Wei, Jing Li
<i>Purpose</i>. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. <i>Methods</i>. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3 mm, 5 mm, and 7 mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. <i>Results</i>. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2 mm), DA ratio max (1 mm), ARTh, integrated radius, SPA1, and CBI <span><svg height="12.7178pt" style="vertical-align:-3.42947pt" version="1.1" viewbox="-0.0498162 -9.28833 23.471 12.7178" width="23.471pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"></path></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"></path></g><g transform="matrix(.013,0,0,-0.013,15.84,0)"></path></g></svg><span></span><span><svg height="12.7178pt" style="vertical-align:-3.42947pt" version="1.1" viewbox="27.053183800000003 -9.28833 26.453 12.7178" width="26.453pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,27.103,0)"></path></g><g transform="matrix(.013,0,0,-0.013,33.343,0)"></path></g><g transform="matrix(.013,0,0,-0.013,36.307,0)"><use xlink:href="#g113-49"></use></g><g transform="matrix(.013,0,0,-0.013,42.547,0)"></path></g><g transform="matrix(.013,0,0,-0.013,48.787,0)"></path></g></svg>.</span></span> The CVs of the Group B subgroups were significantly lower than those of Group A for each diameter range <span><svg height="12.7178pt" style="vertical-align:-3.42947pt" version="1.1" viewbox="-0.0498162 -9.28833 23.471 12.7178" width="23.471pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g113-41"></use></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><use xlink:href="#g113-113"></use></g><g transform="matrix(.013,0,0,-0.013,15.84,0)"><use xlink:href="#g117-91"></use></g></svg><span></span><span><svg height="12.7178pt" style="vertical-align:-3.42947pt" version="1.1" viewbox="27.053183800000003 -9.28833 26.453 12.7178" width="26.453pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,27.103,0)"><use xlink:href="#g113-49"></use></g><g transform="matrix(.013,0,0,-0.013,33.343,0)"><use xlink:href="#g113-47"></use></g><g transform="matrix(.013,0,0,-0.013,36.307,0)"><use xlink:href="#g113-49"></use></g><g transform="matrix(.013,0,0,-0.013,42.547,0)"></path><
目的研究角膜塑形镜(KC)不同区域的角膜体积(CV)与角膜生物力学之间的关系,以及 CV 在诊断和分期 KC 中的意义。方法。这项前瞻性临床研究包括 456 只角膜炎眼(B 组)和 198 只正常眼(A 组)。采用地形学 KC 分级法,根据严重程度(轻度、中度和重度)将 B 组划分为若干亚组。通过 Pentacam 和 Corvis ST 获得了 3 毫米、5 毫米和 7 毫米区域的 CV 值和生物力学参数。通过接收器操作特征曲线(ROC)分析确定了多范围 CV 在不同疾病分期和严重程度下的诊断效用。结果显示7 毫米区的 CV 与 A1V、A2T、PD、DA 比值最大值(2 毫米)、DA 比值最大值(1 毫米)、ARTh、综合半径、SPA1 和 CBI 的相关性最强。在每个直径范围内,B 组亚组的 CV 值都明显低于 A 组。在 3 毫米区,重度、轻度和中度亚组之间存在明显差异(,全部)。在各组中,3 毫米区 CV 在区分 KC 和正常角膜方面表现出更好的诊断能力(A 组 vs. B 组:ROC 曲线下面积 (AUC) = 0.926,A 组 vs. B1 组:ROC 曲线下面积 (AUC) = 0.894,A 组 vs. B1 组:ROC 曲线下面积 (AUC) = 0.926):AUC = 0.894,A 组与 B2 组:ROC 曲线下面积(AUC) = 0.925,A 组与 B1 组:AUC = 0.894,A 组与 B2 组:AUC = 0.925,A 组与 B3 组:AUC = 0.925:AUC = 0.925,A 组与 B3 组:AUC = 0.953)。结论角膜病变眼的 CV 明显下降。3 毫米区域的逐渐变薄可能是检测和分期 KC 的重要测量指标。将 CV 检查与角膜生物力学信息相结合可有效提高检测 KC 的能力。
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引用次数: 0
Indications and Outcomes of Intraocular Lens Explantation in a Tertiary Eyecare Center in Hungary between 2006 and 2020 2006 年至 2020 年匈牙利一家三级眼科中心的眼内晶体爆破适应症和结果
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-05-24 DOI: 10.1155/2024/6653621
Márton Magyar, Nóra Szentmáry, László Ujváry, Gábor László Sándor, Frank Schirra, Zoltán Zsolt Nagy, Gábor Tóth
<i>Purpose</i>. Our study aimed to evaluate the indications and outcomes of intraocular lens (IOL) explantation surgeries in a tertiary eyecare center in Hungary. <i>Materials and Methods</i>. This retrospective study included all IOL explantation surgeries performed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary. There were no exclusion criteria for this study. For each patient, the demographics, clinical history, preoperative status, indications for IOL explantation, and operative and postoperative details were reviewed. Primary outcomes included explantation indications and the type of secondary implanted IOL. <i>Results</i>. A total of 161 eyes from 153 patients were included (96 males; 62.7%); age at the time of the IOL explantation was 65.0 ± 17.4 years. The mean time between primary cataract surgery and IOL explantation was 8.5 ± 7.7 years. In total, 139 (86.3%) PCIOLs and 22 (13.7%) ACIOLs were explanted. The main indications for IOL explantation were dislocation (<i>n</i> = 133; 95.7%) and refractive cause (<i>n</i> = 2; 1.4%) in the PCIOL group. Among ACIOL explantations, the main reasons were pseudophakic bullous keratopathy (<i>n</i> = 14; 63.6%), dislocation (<i>n</i> = 4; 18.2%), and refractive cause (<i>n</i> = 2; 9.1%). In the PCIOL group, 115 (82.7%) primary IOLs were implanted in the capsular bag, 16 (11.5%) were sulcus fixated, and 8 (5.8%) were scleral fixated. The most frequent ocular comorbidities were previous vitrectomy (<i>n</i> = 50, 31.1%), previous ocular trauma (<i>n</i> = 45, 28.0%), glaucoma (<i>n</i> = 16, 9.9%), pseudoexfoliation syndrome (<i>n</i> = 15, 9.3%), and high axial myopia (<i>n</i> = 14, 8.7%). The most commonly used secondary IOL implant was the prepupillary iris-claw IOL (<i>n</i> = 115, 73.7%), followed by the retropupillary iris-claw IOL (<i>n</i> = 32, 20.5%). Uncorrected visual acuity (UCVA) was significantly better following IOL exchange in the entire sample (1.57 ± 0.61 (range: 2.40–0.05) vs. 0.77 ± 0.56 (range: 2.40–0.00); <span><svg height="11.7782pt" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 18.973 11.7782" width="18.973pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"></path></g></svg><span></span><span><svg height="11.7782pt" style="vertical-align:-3.42938pt" version="1.1" viewbox="22.555183800000002 -8.34882 28.184 11.7782" width="28.184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,22.605,0)"></path></g><g transform="matrix(.013,0,0,-0.013,28.845,0)"></path></g><g transform="matrix(.013,0,0,-0.013,31.809,0)"><use xlink:href="#g113-49"></use></g><g transform="matrix(.013,0,0,-0.013,38.049,0)"><use xlink:href="#g113-49"></use></g><g transform="matrix(.013,0,0,-0.013,44.289,0)"></path></g></svg>).</spa
研究目的我们的研究旨在评估匈牙利一家三级眼科中心的眼内晶状体(IOL)置换手术的适应症和结果。材料和方法。这项回顾性研究包括匈牙利布达佩斯塞梅尔维斯大学眼科系在 2006 年至 2020 年期间进行的所有人工晶体置换手术。本研究没有排除标准。研究人员审查了每位患者的人口统计学特征、临床病史、术前状态、人工晶体置换适应症以及手术和术后详情。主要结果包括晶体摘除适应症和二次植入人工晶体的类型。结果。共纳入了 153 名患者的 161 只眼睛(96 名男性;62.7%);人工晶体取出时的年龄为 65.0 ± 17.4 岁。初次白内障手术与人工晶体取出手术之间的平均间隔时间为(8.5 ± 7.7)年。共有 139 个(86.3%)PCIOL 和 22 个(13.7%)ACIOL 被摘除。在 PCIOL 组中,人工晶体摘除的主要适应症是脱位(133 个;95.7%)和屈光原因(2 个;1.4%)。在 ACIOL 取出手术中,主要原因是假性角膜牛皮癣(14 例;63.6%)、脱位(4 例;18.2%)和屈光原因(2 例;9.1%)。在 PCIOL 组中,115 个(82.7%)主要人工晶体植入囊袋,16 个(11.5%)植入沟固定,8 个(5.8%)植入巩膜固定。最常见的眼部合并症是既往玻璃体切除术(50 例,31.1%)、既往眼外伤(45 例,28.0%)、青光眼(16 例,9.9%)、假性角膜剥脱综合征(15 例,9.3%)和高度轴性近视(14 例,8.7%)。最常用的二次人工晶体植入是瞳孔前虹膜爪人工晶体(115 例,73.7%),其次是瞳孔后虹膜爪人工晶体(32 例,20.5%)。在所有样本中,更换人工晶体后未矫正视力(UCVA)明显提高(1.57 ± 0.61(范围:2.40-0.05)对 0.77 ± 0.56(范围:2.40-0.00);)。80.7%的病例在人工晶体置换后保持或提高了最佳矫正视力(BCVA)。结论在匈牙利的一家三级眼科中心,人工晶体置换术最常见的适应症是人工晶体脱位,其次是假性角膜牛皮癣。瞳孔前和瞳孔后虹膜爪式人工晶体是最常用的二次植入物,使用它们可在人工晶体置换后显著改善UCVA。
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引用次数: 0
Changes in the Biomechanical Properties of Corneal Stromal Lens after Collagen Crosslinking Induced by EDC-NHS EDC-NHS 诱导胶原交联后角膜基质透镜生物力学特性的变化
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-05-17 DOI: 10.1155/2024/9943458
Rong Shi, Lijing Wang, Chengpeng Liang, Yu Cheng, Tai Xiang Liu, Xin Luo
Introduction. To evaluate the changes of lens antidilatation, antiedema, and antienzymolysis ability after different concentrations of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide (EDC-NHS)-induced collagen cross-linking. Methods. Corneal stromal lenticules (n = 100) obtained from small incision lenticule extraction (SMILE) procedures were divided into 5 groups: no treatment (control); EDC/NHS (5%/2.5%); EDC/NHS(5%/5%); EDC/NHS (10%/5%); riboflavin and ultraviolet-A light (UVA). Collagen crosslinking was induced using EDC-NHS and UVA. Biomechanical assessments including inflation test, enzymatic degradation resistance, and light transmittance were evaluated posttreatment. Results. (1) Lenticule apex displacement ranked: control Group > UVA Group > Group (5%/5%) > Group (5%/2.5%) > Group (10%/5%) (Friedman test, ). (2) Light transmittance was significantly higher in the crosslinked groups versus control, with EDC/NHS superior to UVA riboflavin. After 15 minutes in PBS, light transmittance decreased due to swelling; however, crosslinked groups maintained significantly higher transmittance versus control. (3) Following crosslinking, enzymatic resistance improved significantly, with the EDC-NHS crosslinking group was significantly better than the UVA cross-linking group. Conclusions. EDC/NHS crosslinking enhanced lenticule stiffness, antiedema, and enzymatic resistance and without compromising the transparency of the lens. Moreover, EDC/NHS crosslinking efficacy exceeded UVA riboflavin crosslinking in improving lenticule biomechanical properties.
引言评估不同浓度的 1-乙基-3-(3-二甲基氨基丙基)碳二亚胺和 N-羟基琥珀酰亚胺(EDC-NHS)诱导胶原交联后晶状体抗扩张、抗水肿和抗酵母溶解能力的变化。方法:角膜基质透镜将小切口皮孔摘除术(SMILE)中获得的角膜基质皮孔(n = 100)分为 5 组:无处理组(对照组);EDC/NHS(5%/2.5%)组;EDC/NHS(5%/5%)组;EDC/NHS(10%/5%)组;核黄素和紫外线 A 光(UVA)组。使用 EDC-NHS 和 UVA 诱导胶原交联。处理后进行了生物力学评估,包括充气试验、抗酶降解性和透光率。结果(1) 皮瓣顶点位移排名:对照组;UVA 组;组(5%/5%);组(5%/2.5%);组(10%/5%)(Friedman 检验,)。 (2) 与对照组相比,交联组的透光率明显更高,其中 EDC/NHS 优于 UVA 核黄素。在 PBS 中浸泡 15 分钟后,透光率因膨胀而下降;但交联组的透光率仍明显高于对照组。(3)交联后,抗酶性明显改善,EDC-NHS 交联组明显优于 UVA 交联组。结论EDC/NHS 交联增强了晶状体的硬度、抗水肿性和抗酶性,且不影响晶状体的透明度。此外,在改善晶状体生物力学特性方面,EDC/NHS 交联的功效超过了 UVA 核黄素交联。
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引用次数: 0
The Performance of Spot Photoscreener in 6 to 10 Weeks Infants in China: A Cross-Sectional Study 中国 6 至 10 周婴儿的光斑照度计性能:横断面研究
IF 1.9 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2024-05-11 DOI: 10.1155/2024/8817530
Yaoling Li, Jing Li, Huiyu Wang, Mingyang Du, Lirong Wei, Teng Su, Gang Ding, Xuehan Qian, Ning Hua
Purpose. To compare the refractive errors measured by the Spot photoscreener (with or without cycloplegia) to cycloplegic retinoscopy in 6- to 10-week-old infants. Materials and Methods. 101 right eyes from 101 healthy infants aged 6 to 10 weeks were recruited for this cross-sectional observational study. Refractive errors were measured using Spot photoscreener before and after cycloplegia, as well as cycloplegic retinoscopy. Comparisons between the refractive measurements were performed using one-way ANOVA with the post hoc Tukey HSD test or Kruskal–Wallis test with the Steel–Dwass test according to the data normality. Pearson’s correlation test and 95% confidence intervals were calculated. The agreement was evaluated using a Bland–Altman plot with 95% limits of agreement of the differences. Results. Spot photoscreener was found to underestimate the spherical equivalent by 2.33 Diopters (D) in these infants. Following the induction of cycloplegia, the spherical equivalent measured by Spot photoscreener was in excellent agreement with cycloplegic retinoscopy with the mean difference of 0.01 D. Spot photoscreener overestimated cylindrical parameter by 0.2 D with poor agreement with cycloplegic retinoscopy no matter whether cycloplegia was induced. It had good agreement with cycloplegic retinoscopy in the vector than the vector measurement. Conclusions. With the induction of cycloplegia, Spot photoscreener can accurately evaluate spherical equivalent in hyperopic infants with mild-to-moderate astigmatism. While it may provide valuable measurements of astigmatism, discrepancies in cylinder and axis should be taken into account.
目的在 6 到 10 周大的婴儿中,比较用 Spot 光筛仪(带或不带环形屈光镜)和环形屈光镜视网膜镜测得的屈光不正。材料和方法。这项横断面观察研究招募了 101 名 6 至 10 周大健康婴儿的 101 只右眼。在环形屈光手术前后使用点光筛查仪测量屈光不正,并进行环形屈光视网膜镜检查。根据数据的正态性,采用单因素方差分析和事后Tukey HSD检验或Kruskal-Wallis检验和Steel-Dwass检验对屈光测量结果进行比较。计算了皮尔逊相关性检验和 95% 的置信区间。使用布兰德-阿尔特曼图对差异的 95% 一致度进行评估。结果。发现点光筛查仪将这些婴儿的球面等效度数低估了 2.33 屈光度 (D)。在诱导环形角膜塑形术后,点阵光度计测量的球面等效度数与环形角膜塑形术视网膜镜测得的球面等效度数非常一致,平均相差 0.01 D。无论是否诱导了屈光不正,点阵光度计都会高估圆柱参数 0.2 D,与屈光视网膜镜的一致性较差。在矢量测量中,它与环形视网膜镜的一致性要好于矢量测量。结论。在诱导屈光不正的情况下,点光筛可以准确评估轻度至中度散光的远视婴儿的球面等值。虽然它可以提供有价值的散光测量值,但应考虑到柱面和轴线的差异。
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Journal of Ophthalmology
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