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Indications and Outcomes of Intraocular Lens Explantation in a Tertiary Eyecare Center in Hungary between 2006 and 2020 2006 年至 2020 年匈牙利一家三级眼科中心的眼内晶体爆破适应症和结果
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-05-24 DOI: 10.1155/2024/6653621
Márton Magyar, Nóra Szentmáry, László Ujváry, Gábor László Sándor, Frank Schirra, Zoltán Zsolt Nagy, Gábor Tóth
Purpose. Our study aimed to evaluate the indications and outcomes of intraocular lens (IOL) explantation surgeries in a tertiary eyecare center in Hungary. Materials and Methods. This retrospective study included all IOL explantation surgeries performed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary. There were no exclusion criteria for this study. For each patient, the demographics, clinical history, preoperative status, indications for IOL explantation, and operative and postoperative details were reviewed. Primary outcomes included explantation indications and the type of secondary implanted IOL. Results. A total of 161 eyes from 153 patients were included (96 males; 62.7%); age at the time of the IOL explantation was 65.0 ± 17.4 years. The mean time between primary cataract surgery and IOL explantation was 8.5 ± 7.7 years. In total, 139 (86.3%) PCIOLs and 22 (13.7%) ACIOLs were explanted. The main indications for IOL explantation were dislocation (n = 133; 95.7%) and refractive cause (n = 2; 1.4%) in the PCIOL group. Among ACIOL explantations, the main reasons were pseudophakic bullous keratopathy (n = 14; 63.6%), dislocation (n = 4; 18.2%), and refractive cause (n = 2; 9.1%). In the PCIOL group, 115 (82.7%) primary IOLs were implanted in the capsular bag, 16 (11.5%) were sulcus fixated, and 8 (5.8%) were scleral fixated. The most frequent ocular comorbidities were previous vitrectomy (n = 50, 31.1%), previous ocular trauma (n = 45, 28.0%), glaucoma (n = 16, 9.9%), pseudoexfoliation syndrome (n = 15, 9.3%), and high axial myopia (n = 14, 8.7%). The most commonly used secondary IOL implant was the prepupillary iris-claw IOL (n = 115, 73.7%), followed by the retropupillary iris-claw IOL (n = 32, 20.5%). Uncorrected visual acuity (UCVA) was significantly better following IOL exchange in the entire sample (1.57 ± 0.61 (range: 2.40–0.05) vs. 0.77 ± 0.56 (range: 2.40–0.00); ).
研究目的我们的研究旨在评估匈牙利一家三级眼科中心的眼内晶状体(IOL)置换手术的适应症和结果。材料和方法。这项回顾性研究包括匈牙利布达佩斯塞梅尔维斯大学眼科系在 2006 年至 2020 年期间进行的所有人工晶体置换手术。本研究没有排除标准。研究人员审查了每位患者的人口统计学特征、临床病史、术前状态、人工晶体置换适应症以及手术和术后详情。主要结果包括晶体摘除适应症和二次植入人工晶体的类型。结果。共纳入了 153 名患者的 161 只眼睛(96 名男性;62.7%);人工晶体取出时的年龄为 65.0 ± 17.4 岁。初次白内障手术与人工晶体取出手术之间的平均间隔时间为(8.5 ± 7.7)年。共有 139 个(86.3%)PCIOL 和 22 个(13.7%)ACIOL 被摘除。在 PCIOL 组中,人工晶体摘除的主要适应症是脱位(133 个;95.7%)和屈光原因(2 个;1.4%)。在 ACIOL 取出手术中,主要原因是假性角膜牛皮癣(14 例;63.6%)、脱位(4 例;18.2%)和屈光原因(2 例;9.1%)。在 PCIOL 组中,115 个(82.7%)主要人工晶体植入囊袋,16 个(11.5%)植入沟固定,8 个(5.8%)植入巩膜固定。最常见的眼部合并症是既往玻璃体切除术(50 例,31.1%)、既往眼外伤(45 例,28.0%)、青光眼(16 例,9.9%)、假性角膜剥脱综合征(15 例,9.3%)和高度轴性近视(14 例,8.7%)。最常用的二次人工晶体植入是瞳孔前虹膜爪人工晶体(115 例,73.7%),其次是瞳孔后虹膜爪人工晶体(32 例,20.5%)。在所有样本中,更换人工晶体后未矫正视力(UCVA)明显提高(1.57 ± 0.61(范围:2.40-0.05)对 0.77 ± 0.56(范围:2.40-0.00);)。80.7%的病例在人工晶体置换后保持或提高了最佳矫正视力(BCVA)。结论在匈牙利的一家三级眼科中心,人工晶体置换术最常见的适应症是人工晶体脱位,其次是假性角膜牛皮癣。瞳孔前和瞳孔后虹膜爪式人工晶体是最常用的二次植入物,使用它们可在人工晶体置换后显著改善UCVA。
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引用次数: 0
Clinical Observation of Posterior-Chamber Phakic Implantable Collamer Lens V4c Implantation in Myopic Patients with Shallow Anterior Chamber Depth: A Retrospective, Consecutive Observational Study 前房深度较浅的近视患者植入后房型可植入人工晶体 V4c 的临床观察:一项回顾性连续观察研究
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-05-22 DOI: 10.1155/2024/3181569
Juan Yuan, Shuang Wu, Zongli Hu, Chunlin Chen, Shiyang Ye, Jian Ye
Purpose. The reference range for the preoperative anterior chamber angle width for ICL surgery is unclear. Our objective was to assess the clinical effect and the range of anterior chamber angle width of posterior-chamber implantable collamer lens V4c (ICL V4c) implantation in patients with anterior chamber depth (ACD) < 2.8 mm. Methods. Patients who underwent ICL V4c implantation with shallow ACD were included in this retrospective study. The patients’ uncorrected and corrected distance visual acuity, angle of trabecular-iris (TIA), angle-opening distance (AOD500), trabecular-iris space area (TISA500), corneal endothelial cell density, vault, retinal nerve fiber layer thickness, intraocular pressure, visual field, and complications were analyzed. Results. Forty-one patients (68 eyes) completed at least 12 months of follow-up (median follow-up, 30 months). The effectiveness and safety indices were 1.09 ± 0.13 and 1.04 ± 0.21, respectively. The preoperative TIA values on the nasal and temporal sides were 39.78 ± 7.68 degree (range, 25.8-65.1 degree) and 41.54 ± 8.03 degree (range, 28.5-63.00 degree). Forty-seven eyes had uncorrected distance visual acuity ≥1.0, and 55 had corrected distance visual acuity ≥1.0 at the last follow-up visit. The TIA, AOD500, and TISA500 on the nasal and temporal sides were significantly reduced compared to those before surgery (all P<0.01); no eye had an angle closure or elevated intraocular pressure. The ICL V4c vault was 290.88 ± 153.36 μm (range, 60.0-880.0 μm). No severe complications occurred in any patient. Conclusions. In patients with myopia with shallow ACD (2.55-2.79 mm), a preoperative TIA >25.8° is safe and effective for a relatively long time after surgery; however, an extended long-term close follow-up is needed.
目的。ICL手术术前前房角度宽度的参考范围尚不明确。我们的目的是评估前房深度(ACD)为 25.8°的患者植入后房植入性有晶体眼人工晶体 V4c(ICL V4c)的临床效果和前房角宽度范围,该手术在术后相对较长的时间内都是安全有效的;但是,还需要长期密切随访。
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引用次数: 0
LASIK Videos on TikTok: A Content Analysis of the Top 100 Videos TikTok 上的 LASIK 视频:前 100 条视频的内容分析
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-05-21 DOI: 10.1155/2024/8810500
Firas Haddad, Joanna S. Saade
Introduction. Social media has increasingly become a prominent source of health information. Platforms like TikTok that allow for videos to reach millions of viewers have become among the most common platforms to share and receive health information. Laser in situ keratomileusis (LASIK) videos and patients’ experiences are commonly discussed on social media. The quality of these videos remains to be assessed. The aim of this study is to evaluate the content, quality, and reach of the top 100 videos related to LASIK eye surgery on TikTok. Methods. Video quality was assessed using the DISCERN, JAMA, and GQS instruments which have all been proven to be both reliable and valid. Results. 100 videos were included in the study. Results showed that the videos have an immense reach with a total view count of 245 million views and 21.9 million likes. Two thirds of the videos were posted by personal accounts as compared ophthalmologists that only constituted 26% of the content. Healthcare professionals produced higher quality videos compared to nonhealthcare professionals (p<0.0001) although there was no significant difference in video duration (p=0.18). Increased duration, view count, comments, shares, saves, and views/day were all associated with increased DISCERN score and quality of the videos. Educational videos were of higher quality compared to entertainment videos, and videos outlining the procedure details had the highest quality score. Conclusions. LASIK videos on TikTok have established a wide reach, whereby viewers are highly interacting and viewing these videos. It appeared that viewers interacted more with the higher quality videos. Ophthalmologists approximately only contributed to a quarter of the videos analyzed in this study. This highlights the need for ophthalmologists to establish a presence on TikTok and produce high quality videos.
简介社交媒体已日益成为健康信息的重要来源。像 TikTok 这样可以让数百万观众观看视频的平台已成为分享和接收健康信息的最常见平台之一。社交媒体上通常会讨论激光原位角膜磨镶术(LASIK)视频和患者的经历。这些视频的质量仍有待评估。本研究旨在评估 TikTok 上与 LASIK 眼科手术相关的前 100 个视频的内容、质量和传播范围。研究方法使用 DISCERN、JAMA 和 GQS 工具对视频质量进行评估,这些工具均已被证明可靠有效。结果研究共纳入 100 个视频。结果显示,这些视频的覆盖面非常广,总观看次数达 2.45 亿次,点赞数达 2190 万次。三分之二的视频是由个人账户发布的,而眼科医生发布的视频内容只占 26%。与非医疗保健专业人员相比,医疗保健专业人员制作的视频质量更高(p<0.0001),但视频持续时间没有显著差异(p=0.18)。持续时间、观看次数、评论、分享、保存和观看次数/天数的增加都与 DISCERN 分数和视频质量的提高有关。与娱乐视频相比,教育视频的质量更高,概述手术细节的视频质量得分最高。结论TikTok上的LASIK视频已经建立了广泛的影响力,观众对这些视频的互动和观看程度都很高。观众似乎与质量较高的视频互动更多。在本研究分析的视频中,眼科医生大约只贡献了四分之一。这凸显了眼科医生在 TikTok 上建立影响力并制作高质量视频的必要性。
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引用次数: 0
Changes in the Biomechanical Properties of Corneal Stromal Lens after Collagen Crosslinking Induced by EDC-NHS EDC-NHS 诱导胶原交联后角膜基质透镜生物力学特性的变化
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-05-17 DOI: 10.1155/2024/9943458
Rong Shi, Lijing Wang, Chengpeng Liang, Yu Cheng, Tai Xiang Liu, Xin Luo
Introduction. To evaluate the changes of lens antidilatation, antiedema, and antienzymolysis ability after different concentrations of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide (EDC-NHS)-induced collagen cross-linking. Methods. Corneal stromal lenticules (n = 100) obtained from small incision lenticule extraction (SMILE) procedures were divided into 5 groups: no treatment (control); EDC/NHS (5%/2.5%); EDC/NHS(5%/5%); EDC/NHS (10%/5%); riboflavin and ultraviolet-A light (UVA). Collagen crosslinking was induced using EDC-NHS and UVA. Biomechanical assessments including inflation test, enzymatic degradation resistance, and light transmittance were evaluated posttreatment. Results. (1) Lenticule apex displacement ranked: control Group > UVA Group > Group (5%/5%) > Group (5%/2.5%) > Group (10%/5%) (Friedman test, ). (2) Light transmittance was significantly higher in the crosslinked groups versus control, with EDC/NHS superior to UVA riboflavin. After 15 minutes in PBS, light transmittance decreased due to swelling; however, crosslinked groups maintained significantly higher transmittance versus control. (3) Following crosslinking, enzymatic resistance improved significantly, with the EDC-NHS crosslinking group was significantly better than the UVA cross-linking group. Conclusions. EDC/NHS crosslinking enhanced lenticule stiffness, antiedema, and enzymatic resistance and without compromising the transparency of the lens. Moreover, EDC/NHS crosslinking efficacy exceeded UVA riboflavin crosslinking in improving lenticule biomechanical properties.
引言评估不同浓度的 1-乙基-3-(3-二甲基氨基丙基)碳二亚胺和 N-羟基琥珀酰亚胺(EDC-NHS)诱导胶原交联后晶状体抗扩张、抗水肿和抗酵母溶解能力的变化。方法:角膜基质透镜将小切口皮孔摘除术(SMILE)中获得的角膜基质皮孔(n = 100)分为 5 组:无处理组(对照组);EDC/NHS(5%/2.5%)组;EDC/NHS(5%/5%)组;EDC/NHS(10%/5%)组;核黄素和紫外线 A 光(UVA)组。使用 EDC-NHS 和 UVA 诱导胶原交联。处理后进行了生物力学评估,包括充气试验、抗酶降解性和透光率。结果(1) 皮瓣顶点位移排名:对照组;UVA 组;组(5%/5%);组(5%/2.5%);组(10%/5%)(Friedman 检验,)。 (2) 与对照组相比,交联组的透光率明显更高,其中 EDC/NHS 优于 UVA 核黄素。在 PBS 中浸泡 15 分钟后,透光率因膨胀而下降;但交联组的透光率仍明显高于对照组。(3)交联后,抗酶性明显改善,EDC-NHS 交联组明显优于 UVA 交联组。结论EDC/NHS 交联增强了晶状体的硬度、抗水肿性和抗酶性,且不影响晶状体的透明度。此外,在改善晶状体生物力学特性方面,EDC/NHS 交联的功效超过了 UVA 核黄素交联。
{"title":"Changes in the Biomechanical Properties of Corneal Stromal Lens after Collagen Crosslinking Induced by EDC-NHS","authors":"Rong Shi, Lijing Wang, Chengpeng Liang, Yu Cheng, Tai Xiang Liu, Xin Luo","doi":"10.1155/2024/9943458","DOIUrl":"https://doi.org/10.1155/2024/9943458","url":null,"abstract":"<i>Introduction</i>. To evaluate the changes of lens antidilatation, antiedema, and antienzymolysis ability after different concentrations of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide (EDC-NHS)-induced collagen cross-linking. <i>Methods</i>. Corneal stromal lenticules (<i>n</i> = 100) obtained from small incision lenticule extraction (SMILE) procedures were divided into 5 groups: no treatment (control); EDC/NHS (5%/2.5%); EDC/NHS(5%/5%); EDC/NHS (10%/5%); riboflavin and ultraviolet-A light (UVA). Collagen crosslinking was induced using EDC-NHS and UVA. Biomechanical assessments including inflation test, enzymatic degradation resistance, and light transmittance were evaluated posttreatment. <i>Results</i>. (1) Lenticule apex displacement ranked: control Group &gt; UVA Group &gt; Group (5%/5%) &gt; Group (5%/2.5%) &gt; Group (10%/5%) (Friedman test, <span><svg height=\"11.7782pt\" style=\"vertical-align:-3.42938pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.34882 18.973 11.7782\" width=\"18.973pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,11.342,0)\"></path></g></svg><span></span><span><svg height=\"11.7782pt\" style=\"vertical-align:-3.42938pt\" version=\"1.1\" viewbox=\"22.555183800000002 -8.34882 34.448 11.7782\" width=\"34.448pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,22.605,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,28.845,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,31.809,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,38.049,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,44.289,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,50.529,0)\"></path></g></svg>).</span></span> (2) Light transmittance was significantly higher in the crosslinked groups versus control, with EDC/NHS superior to UVA riboflavin. After 15 minutes in PBS, light transmittance decreased due to swelling; however, crosslinked groups maintained significantly higher transmittance versus control. (3) Following crosslinking, enzymatic resistance improved significantly, with the EDC-NHS crosslinking group was significantly better than the UVA cross-linking group. <i>Conclusions</i>. EDC/NHS crosslinking enhanced lenticule stiffness, antiedema, and enzymatic resistance and without compromising the transparency of the lens. Moreover, EDC/NHS crosslinking efficacy exceeded UVA riboflavin crosslinking in improving lenticule biomechanical properties.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141062444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Performance of Spot Photoscreener in 6 to 10 Weeks Infants in China: A Cross-Sectional Study 中国 6 至 10 周婴儿的光斑照度计性能:横断面研究
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-05-11 DOI: 10.1155/2024/8817530
Yaoling Li, Jing Li, Huiyu Wang, Mingyang Du, Lirong Wei, Teng Su, Gang Ding, Xuehan Qian, Ning Hua
Purpose. To compare the refractive errors measured by the Spot photoscreener (with or without cycloplegia) to cycloplegic retinoscopy in 6- to 10-week-old infants. Materials and Methods. 101 right eyes from 101 healthy infants aged 6 to 10 weeks were recruited for this cross-sectional observational study. Refractive errors were measured using Spot photoscreener before and after cycloplegia, as well as cycloplegic retinoscopy. Comparisons between the refractive measurements were performed using one-way ANOVA with the post hoc Tukey HSD test or Kruskal–Wallis test with the Steel–Dwass test according to the data normality. Pearson’s correlation test and 95% confidence intervals were calculated. The agreement was evaluated using a Bland–Altman plot with 95% limits of agreement of the differences. Results. Spot photoscreener was found to underestimate the spherical equivalent by 2.33 Diopters (D) in these infants. Following the induction of cycloplegia, the spherical equivalent measured by Spot photoscreener was in excellent agreement with cycloplegic retinoscopy with the mean difference of 0.01 D. Spot photoscreener overestimated cylindrical parameter by 0.2 D with poor agreement with cycloplegic retinoscopy no matter whether cycloplegia was induced. It had good agreement with cycloplegic retinoscopy in the vector than the vector measurement. Conclusions. With the induction of cycloplegia, Spot photoscreener can accurately evaluate spherical equivalent in hyperopic infants with mild-to-moderate astigmatism. While it may provide valuable measurements of astigmatism, discrepancies in cylinder and axis should be taken into account.
目的在 6 到 10 周大的婴儿中,比较用 Spot 光筛仪(带或不带环形屈光镜)和环形屈光镜视网膜镜测得的屈光不正。材料和方法。这项横断面观察研究招募了 101 名 6 至 10 周大健康婴儿的 101 只右眼。在环形屈光手术前后使用点光筛查仪测量屈光不正,并进行环形屈光视网膜镜检查。根据数据的正态性,采用单因素方差分析和事后Tukey HSD检验或Kruskal-Wallis检验和Steel-Dwass检验对屈光测量结果进行比较。计算了皮尔逊相关性检验和 95% 的置信区间。使用布兰德-阿尔特曼图对差异的 95% 一致度进行评估。结果。发现点光筛查仪将这些婴儿的球面等效度数低估了 2.33 屈光度 (D)。在诱导环形角膜塑形术后,点阵光度计测量的球面等效度数与环形角膜塑形术视网膜镜测得的球面等效度数非常一致,平均相差 0.01 D。无论是否诱导了屈光不正,点阵光度计都会高估圆柱参数 0.2 D,与屈光视网膜镜的一致性较差。在矢量测量中,它与环形视网膜镜的一致性要好于矢量测量。结论。在诱导屈光不正的情况下,点光筛可以准确评估轻度至中度散光的远视婴儿的球面等值。虽然它可以提供有价值的散光测量值,但应考虑到柱面和轴线的差异。
{"title":"The Performance of Spot Photoscreener in 6 to 10 Weeks Infants in China: A Cross-Sectional Study","authors":"Yaoling Li, Jing Li, Huiyu Wang, Mingyang Du, Lirong Wei, Teng Su, Gang Ding, Xuehan Qian, Ning Hua","doi":"10.1155/2024/8817530","DOIUrl":"https://doi.org/10.1155/2024/8817530","url":null,"abstract":"<i>Purpose</i>. To compare the refractive errors measured by the Spot photoscreener (with or without cycloplegia) to cycloplegic retinoscopy in 6- to 10-week-old infants. <i>Materials and Methods</i>. 101 right eyes from 101 healthy infants aged 6 to 10 weeks were recruited for this cross-sectional observational study. Refractive errors were measured using Spot photoscreener before and after cycloplegia, as well as cycloplegic retinoscopy. Comparisons between the refractive measurements were performed using one-way ANOVA with the post hoc Tukey HSD test or Kruskal–Wallis test with the Steel–Dwass test according to the data normality. Pearson’s correlation test and 95% confidence intervals were calculated. The agreement was evaluated using a Bland–Altman plot with 95% limits of agreement of the differences. <i>Results</i>. Spot photoscreener was found to underestimate the spherical equivalent by 2.33 Diopters (D) in these infants. Following the induction of cycloplegia, the spherical equivalent measured by Spot photoscreener was in excellent agreement with cycloplegic retinoscopy with the mean difference of 0.01 D. Spot photoscreener overestimated cylindrical parameter by 0.2 D with poor agreement with cycloplegic retinoscopy no matter whether cycloplegia was induced. It had good agreement with cycloplegic retinoscopy in the <svg height=\"11.927pt\" style=\"vertical-align:-3.291101pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 10.0959 11.927\" width=\"10.0959pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.0091,0,0,-0.0091,5.031,3.132)\"></path></g></svg> vector than the <svg height=\"11.927pt\" style=\"vertical-align:-3.291101pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 14.5442 11.927\" width=\"14.5442pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-75\"></use></g><g transform=\"matrix(.0091,0,0,-0.0091,5.031,3.132)\"></path></g><g transform=\"matrix(.0091,0,0,-0.0091,9.463,3.132)\"></path></g></svg> vector measurement. <i>Conclusions</i>. With the induction of cycloplegia, Spot photoscreener can accurately evaluate spherical equivalent in hyperopic infants with mild-to-moderate astigmatism. While it may provide valuable measurements of astigmatism, discrepancies in cylinder and axis should be taken into account.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Test-Retest of the Spot Vision Screener among Children with Ophthalmological Diseases including Strabismus 斜视等眼科疾病患儿的点视力筛查测试-复测
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-05-06 DOI: 10.1155/2024/2173860
Mika Ichimura, Satoshi Ueki, Takeo Fukuchi
Background. The spot vision screener (SVS) has been widely used for eye health examinations of infants and young children. The purpose of this study was to evaluate the reproducibility of two SVS measurements in children with ophthalmological diseases. Methods. 29 patients aged 15 years or younger who visited our hospital for refraction examinations with SVS before and at least 60 minutes after administration of 2 drops of 1% cyclopentolate ophthalmic solution (before and after cycloplegia) were included in this study. Two SVS measurements were made before and after cycloplegia, respectively. Intraclass correlation coefficients (ICCs) and Bland–Altman analysis for spherical, spherical equivalent (SE), cylindrical, J0, and J45 values before and after cycloplegia were analyzed. Results. The mean age ± standard deviation (SD) of the 29 patients was 7.6 ± 2.4 years. There were 11 males and 18 females. The mean spherical values based on the SVS before and after cycloplegia were 0.42 ± 1.67 diopter (D), and 1.47 ± 2.23 D for the first measurement and 0.60 ± 1.74 D, and 1.42 ± 2.27 D for the second measurement, respectively. The mean cylindrical values based on SVS before and after cycloplegia were −1.45 ± 0.96 D and −1.65 ± 0.89 D for the first measurement and −1.58 ± 1.13 D and −1.66 ± 0.91 D for the second measurement, respectively. The ICCs for the first and second spherical, SE, cylindrical, J0, and J45 values before cycloplegia were 0.95, 0.98, 0.83, 0.86, and 0.86, respectively. The ICCs for the first and second spherical, SE, cylindrical, J0, and J45 values after cycloplegia were 0.99, 0.99, 0,87, 0.73, and 0.80, respectively. The Bland–Altman analysis of the first and second spherical and SE values before cycloplegia showed fan-shaped variation as hyperopia increased. Conclusions. Two consecutive SVS refraction measurements have a high degree of reproducibility for spherical and SE values but a low degree for cylindrical, J0, and J45 values. From these results, multiple measurements are required to obtain reliable results for cylindrical values.
背景。点视力筛查仪(SVS)已被广泛用于婴幼儿的眼健康检查。本研究旨在评估两种 SVS 测量方法在眼科疾病患儿中的重现性。研究方法本研究选取了 29 名 15 岁或 15 岁以下到我院接受屈光检查的患者,在滴用 2 滴 1%环戊托品眼药水之前和之后至少 60 分钟(在环状麻痹之前和之后)用 SVS 进行测量。分别在环形麻痹前后进行了两次 SVS 测量。对环麻痹前后的球面、球面等值(SE)、圆柱、J0 和 J45 值的类内相关系数(ICC)和 Bland-Altman 分析进行了分析。结果。29 名患者的平均年龄为 7.6±2.4 岁。其中男性 11 人,女性 18 人。第一次测量和第二次测量的平均球面视力值分别为 0.60 ± 1.74 D 和 1.42 ± 2.27 D,而第一次测量和第二次测量的平均球面视力值分别为 0.42 ± 1.67 D 和 1.47 ± 2.23 D。第一次测量和第二次测量的圆柱值分别为-1.58 ± 1.13 D 和-1.66 ± 0.91 D。第一次和第二次测量球面、SE、圆柱、J0 和 J45 值的 ICC 分别为 0.95、0.98、0.83、0.86 和 0.86。环形瞳孔术后第一和第二个球面、SE、圆柱、J0 和 J45 值的 ICC 分别为 0.99、0.99、0,87、0.73 和 0.80。对屈光手术前的第一和第二球面和 SE 值进行的 Bland-Altman 分析显示,随着远视度数的增加,其变化呈扇形。结论。连续两次 SVS 屈光度测量的球镜和 SE 值具有较高的可重复性,但柱镜、J0 和 J45 值的可重复性较低。从这些结果来看,需要多次测量才能获得可靠的圆柱度值结果。
{"title":"Test-Retest of the Spot Vision Screener among Children with Ophthalmological Diseases including Strabismus","authors":"Mika Ichimura, Satoshi Ueki, Takeo Fukuchi","doi":"10.1155/2024/2173860","DOIUrl":"https://doi.org/10.1155/2024/2173860","url":null,"abstract":"<i>Background</i>. The spot vision screener (SVS) has been widely used for eye health examinations of infants and young children. The purpose of this study was to evaluate the reproducibility of two SVS measurements in children with ophthalmological diseases. <i>Methods</i>. 29 patients aged 15 years or younger who visited our hospital for refraction examinations with SVS before and at least 60 minutes after administration of 2 drops of 1% cyclopentolate ophthalmic solution (before and after cycloplegia) were included in this study. Two SVS measurements were made before and after cycloplegia, respectively. Intraclass correlation coefficients (ICCs) and Bland–Altman analysis for spherical, spherical equivalent (SE), cylindrical, J0, and J45 values before and after cycloplegia were analyzed. <i>Results</i>. The mean age ± standard deviation (SD) of the 29 patients was 7.6 ± 2.4 years. There were 11 males and 18 females. The mean spherical values based on the SVS before and after cycloplegia were 0.42 ± 1.67 diopter (D), and 1.47 ± 2.23 D for the first measurement and 0.60 ± 1.74 D, and 1.42 ± 2.27 D for the second measurement, respectively. The mean cylindrical values based on SVS before and after cycloplegia were −1.45 ± 0.96 D and −1.65 ± 0.89 D for the first measurement and −1.58 ± 1.13 D and −1.66 ± 0.91 D for the second measurement, respectively. The ICCs for the first and second spherical, SE, cylindrical, J0, and J45 values before cycloplegia were 0.95, 0.98, 0.83, 0.86, and 0.86, respectively. The ICCs for the first and second spherical, SE, cylindrical, J0, and J45 values after cycloplegia were 0.99, 0.99, 0,87, 0.73, and 0.80, respectively. The Bland–Altman analysis of the first and second spherical and SE values before cycloplegia showed fan-shaped variation as hyperopia increased. <i>Conclusions</i>. Two consecutive SVS refraction measurements have a high degree of reproducibility for spherical and SE values but a low degree for cylindrical, J0, and J45 values. From these results, multiple measurements are required to obtain reliable results for cylindrical values.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140889179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health 血脂异常对泪膜和睑板腺功能障碍的影响:血清脂质谱与眼表健康相互作用的横断面研究
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-04-30 DOI: 10.1155/2024/7345270
José-Manuel Serrano-Morales, Noelia Álvarez-Santaliestra, María Carmen Sánchez-González, Antonio Ballesteros-Sánchez, José-María Sánchez-González
Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear film and meibomian glands. Methods. This cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid profile were evaluated after 8 hours of fasting. Patients were classified according to serum lipid levels with the following cut-off values: total cholesterol (TC) (200 mg/dl), high-density lipoprotein (HDL) (40 mg/dl), low-density lipoprotein (LDL) (130 mg/dl), and triglycerides (TG) (150 mg/dl). The relationship between serum lipid levels and DED was analyzed with the following variables: dry eye questionnaire-5 (DEQ-5), first (F-NIBUT) and average (A-NIBUT) noninvasive breakup time, tear meniscus height (TMH), lipid layer grade (LLG), conjunctival bulbar redness (CBR), and upper (U-LAMG) and lower (L-LAMG) loss area of meibomian glands. Results. Regarding tear film, patients with elevated TC and LDL levels reported significantly higher DEQ-5 scores and TMH (), while those with lower HDL levels showed significantly higher LLG (). Regarding MGD, patients wit
目的确定血脂异常与干眼症(DED)之间的关系及其对泪膜和睑板腺的影响。方法:横断面研究这项横断面研究包括 40 名患者,平均年龄为 35.2 ± 13.9 岁,无血脂异常病史。空腹 8 小时后对 DED 和血清脂质概况进行评估。根据血清脂质水平对患者进行分类,截断值如下:总胆固醇(TC)(200 mg/dl)、高密度脂蛋白(HDL)(40 mg/dl)、低密度脂蛋白(LDL)(130 mg/dl)和甘油三酯(TG)(150 mg/dl)。血清脂质水平与 DED 之间的关系通过以下变量进行分析:干眼问卷-5(DEQ-5)、首次(F-NIBUT)和平均(A-NIBUT)无创泪液破裂时间、泪液半月板高度(TMH)、脂质层等级(LLG)、结膜球部发红(CBR)、睑板腺上部(U-LAMG)和下部(L-LAMG)损失面积。结果在泪膜方面,TC 和 LDL 水平升高的患者 DEQ-5 评分和 TMH()明显升高,而 HDL 水平降低的患者 LLG()明显升高。在 MGD 方面,TC、LDL 和 TG 水平升高以及 HDL 水平较低的患者 L-LAMG 明显较高()。高密度脂蛋白与 LLG()相关,而总胆固醇分别与 TMH()和 L-LAMG ()相关。结论总胆固醇、高密度脂蛋白、低密度脂蛋白和总胆固醇水平紊乱与 DED 有关,对泪膜和睑板腺有影响,特别是对 DEQ-5 评分、LLG 和 L-LAMG 有影响。
{"title":"Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health","authors":"José-Manuel Serrano-Morales, Noelia Álvarez-Santaliestra, María Carmen Sánchez-González, Antonio Ballesteros-Sánchez, José-María Sánchez-González","doi":"10.1155/2024/7345270","DOIUrl":"https://doi.org/10.1155/2024/7345270","url":null,"abstract":"<i>Purpose</i>. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear film and meibomian glands. <i>Methods</i>. This cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid profile were evaluated after 8 hours of fasting. Patients were classified according to serum lipid levels with the following cut-off values: total cholesterol (TC) (200 mg/dl), high-density lipoprotein (HDL) (40 mg/dl), low-density lipoprotein (LDL) (130 mg/dl), and triglycerides (TG) (150 mg/dl). The relationship between serum lipid levels and DED was analyzed with the following variables: dry eye questionnaire-5 (DEQ-5), first (F-NIBUT) and average (A-NIBUT) noninvasive breakup time, tear meniscus height (TMH), lipid layer grade (LLG), conjunctival bulbar redness (CBR), and upper (U-LAMG) and lower (L-LAMG) loss area of meibomian glands. <i>Results</i>. Regarding tear film, patients with elevated TC and LDL levels reported significantly higher DEQ-5 scores and TMH (<span><svg height=\"9.2729pt\" style=\"vertical-align:-0.6370001pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 19.289 9.2729\" width=\"19.289pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,11.658,0)\"></path></g></svg><span></span><span><svg height=\"9.2729pt\" style=\"vertical-align:-0.6370001pt\" version=\"1.1\" viewbox=\"22.8711838 -8.6359 21.918 9.2729\" width=\"21.918pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,22.921,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,29.161,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,32.125,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,38.365,0)\"></path></g></svg>),</span></span> while those with lower HDL levels showed significantly higher LLG (<span><svg height=\"11.7782pt\" style=\"vertical-align:-3.42938pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.34882 18.973 11.7782\" width=\"18.973pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g><g transform=\"matrix(.013,0,0,-0.013,11.342,0)\"><use xlink:href=\"#g117-91\"></use></g></svg><span></span><span><svg height=\"11.7782pt\" style=\"vertical-align:-3.42938pt\" version=\"1.1\" viewbox=\"22.555183800000002 -8.34882 21.921 11.7782\" width=\"21.921pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,22.605,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,28.845,0)\"><use xlink:href=\"#g113-47\"></use></g><g transform=\"matrix(.013,0,0,-0.013,31.809,0)\"><use xlink:href=\"#g113-49\"></use></g><g transform=\"matrix(.013,0,0,-0.013,38.049,0)\"><use xlink:href=\"#g113-54\"></use></g></svg>).</span></span> Regarding MGD, patients wit","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis 元基因组下一代测序在传染性角膜炎诊断中的应用
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-04-29 DOI: 10.1155/2024/9911979
Xin-Yu Pan, Meng Wang, Yi-Dan Xu, Lin-Nong Wang
Purpose. To determine the advantages of next-generation metagenomic sequencing (mNGS) technology in the diagnosis and treatment of infectious keratitis (IK). Methods. A total of 287 patients with IK admitted to the Department of Ophthalmology of Nanjing First Hospital between August 2018 and December 2022 were analyzed retrospectively, and the pathogenic causes, etiological characteristics, detection, treatment methods, and efficacy were summarized. Results. Trauma and foreign matter were the most common causes of IK (144 patients, 50.2%). Of the 287 patients, 228 (79.4%) were diagnosed with a specific etiology, including 110 (48.2%) fungal infections, 44 (19.3%) viral infections, 42 (18.4%) mixed infections, and 30 (13.2%) bacterial infections. Filamentous fungi represented by Fusarium and Aspergillus were the most common, followed by bacteria such as Pseudomonas aeruginosa, Streptococcus pneumoniae, viruses (Herpes Simplex Virus/Varicella-Zoster Virus), and parasites. The positivity rates of secretion culture, corneal laser confocal microscopy (CM), mNGS, and pathological sections were 47.3% (133/281), 45.3% (111/245), 83.9% (104/124), and 19.3% (40/207), respectively. The positivity rate of mNGS for bacteria and viruses was higher than that of the other methods, and the positivity rate for fungi was the same as that for CM. As a result, 214 cases (74.6%) were cured, 51 cases (17.8%) improved, 8 cases (2.8%) did not heal, ocular content enucleation was performed in 14 cases (4.9%), and the overall efficacy rate was 92.3%. Conclusion. Trauma and foreign matter are the main causes of IK. The mNGS technology is an efficient and comprehensive detection method for viruses and bacteria, especially for mixed infections.
目的确定下一代元基因组测序(mNGS)技术在诊断和治疗传染性角膜炎(IK)中的优势。方法。回顾性分析2018年8月至2022年12月南京市第一医院眼科收治的共287例IK患者,总结其致病原因、病原学特征、检测方法、治疗方法及疗效。结果显示外伤和异物是IK最常见的病因(144例患者,50.2%)。在 287 名患者中,228 人(79.4%)被确诊为特定病因,包括 110 人(48.2%)真菌感染、44 人(19.3%)病毒感染、42 人(18.4%)混合感染和 30 人(13.2%)细菌感染。以镰刀菌和曲霉菌为代表的丝状真菌最为常见,其次是铜绿假单胞菌、肺炎链球菌等细菌、病毒(单纯疱疹病毒/带状疱疹病毒)和寄生虫。分泌物培养、角膜激光共聚焦显微镜(CM)、mNGS 和病理切片的阳性率分别为 47.3%(133/281)、45.3%(111/245)、83.9%(104/124)和 19.3%(40/207)。mNGS 的细菌和病毒阳性率高于其他方法,真菌阳性率与 CM 相同。结果,214 例(74.6%)治愈,51 例(17.8%)好转,8 例(2.8%)未愈,14 例(4.9%)进行了眼内容物摘除术,总有效率为 92.3%。结论外伤和异物是 IK 的主要原因。mNGS 技术是一种高效、全面的病毒和细菌检测方法,尤其适用于混合感染。
{"title":"Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis","authors":"Xin-Yu Pan, Meng Wang, Yi-Dan Xu, Lin-Nong Wang","doi":"10.1155/2024/9911979","DOIUrl":"https://doi.org/10.1155/2024/9911979","url":null,"abstract":"<i>Purpose</i>. To determine the advantages of next-generation metagenomic sequencing (mNGS) technology in the diagnosis and treatment of infectious keratitis (IK). <i>Methods</i>. A total of 287 patients with IK admitted to the Department of Ophthalmology of Nanjing First Hospital between August 2018 and December 2022 were analyzed retrospectively, and the pathogenic causes, etiological characteristics, detection, treatment methods, and efficacy were summarized. <i>Results</i>. Trauma and foreign matter were the most common causes of IK (144 patients, 50.2%). Of the 287 patients, 228 (79.4%) were diagnosed with a specific etiology, including 110 (48.2%) fungal infections, 44 (19.3%) viral infections, 42 (18.4%) mixed infections, and 30 (13.2%) bacterial infections. Filamentous fungi represented by <i>Fusarium</i> and <i>Aspergillus</i> were the most common, followed by bacteria such as <i>Pseudomonas aeruginosa</i>, <i>Streptococcus pneumoniae</i>, viruses (Herpes Simplex Virus/Varicella-Zoster Virus), and parasites. The positivity rates of secretion culture, corneal laser confocal microscopy (CM), mNGS, and pathological sections were 47.3% (133/281), 45.3% (111/245), 83.9% (104/124), and 19.3% (40/207), respectively. The positivity rate of mNGS for bacteria and viruses was higher than that of the other methods, and the positivity rate for fungi was the same as that for CM. As a result, 214 cases (74.6%) were cured, 51 cases (17.8%) improved, 8 cases (2.8%) did not heal, ocular content enucleation was performed in 14 cases (4.9%), and the overall efficacy rate was 92.3%. <i>Conclusion</i>. Trauma and foreign matter are the main causes of IK. The mNGS technology is an efficient and comprehensive detection method for viruses and bacteria, especially for mixed infections.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140808960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Surgical Safety through Protective Penetrating Keratoplasty: A Retrospective Analysis of 22 Cases 通过保护性穿透角膜移植术提高手术安全性:22 例病例的回顾性分析
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-04-05 DOI: 10.1155/2024/2718527
Tian Yang, Miguel O. M. Castellanos
Context. Penetrating keratoplasty (PK) is a recognized treatment for corneal damage but possesses inherent risks, mainly due to its open-sky nature, which potentially lead to severe sight-threatening complications. Protective penetrating keratoplasty (PPK) emerges as a novel procedure aimed at mitigating these risks. Aim. To assess the surgical safety, postoperative outcomes, and the impact of PPK on corneal endothelial cell density through a retrospective analysis of 22 cases. Settings and Design. A retrospective cross-sectional observational study was executed at Hermanos Ameijeiras Hospital from February 2018 to December 2021, involving 22 patients (22 eyes) who were unresponsive to other medical treatments and had a corrected distance visual acuity of ≤0.1. Methods and Materials. Patients underwent PPK, with surgical procedures and postoperative care documented. Statistical analysis was performed on qualitative and quantitative variables to evaluate the surgical outcomes and the corneal endothelial cell density changes postoperation. Results. All surgeries demonstrated a significant improvement in postoperative visual acuity () and recorded a 9.2% decrease in the corneal endothelial cell density at 12 months. Noteworthy complications included one case of intraoperatively discovered haptic dislocation and one postoperative bacterial keratitis. Conclusions. PPK could potentially mitigate perioperative complications, ensure graft clarity, and reduce corneal endothelial cell loss, presenting itself as a viable alternative to traditional PK. Although the results are encouraging, larger-scale studies are essential to validate the benefits and applicability of PPK in broader clinical settings.
背景。穿透性角膜成形术(PK)是一种公认的角膜损伤治疗方法,但也存在固有风险,主要是由于其开放性,有可能导致严重的危及视力的并发症。保护性穿透角膜移植术(PPK)作为一种新型手术应运而生,旨在降低这些风险。目的通过对 22 例病例的回顾性分析,评估手术安全性、术后效果以及 PPK 对角膜内皮细胞密度的影响。设置与设计。2018年2月至2021年12月,在Hermanos Ameijeiras医院开展了一项回顾性横断面观察研究,共涉及22名患者(22只眼),这些患者对其他药物治疗无反应,矫正远视力≤0.1。方法和材料。患者接受了 PPK,手术过程和术后护理均有记录。对定性和定量变量进行统计分析,以评估手术效果和术后角膜内皮细胞密度的变化。结果。所有手术的术后视力均有明显改善(),12个月时角膜内皮细胞密度下降了9.2%。值得注意的并发症包括一例术中发现的触点脱位和一例术后细菌性角膜炎。结论。PPK 有可能减轻围手术期并发症,确保移植角膜的清晰度,减少角膜内皮细胞的损失,是传统 PK 的可行替代方案。虽然研究结果令人鼓舞,但要在更广泛的临床环境中验证 PPK 的益处和适用性,还需要进行更大规模的研究。
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引用次数: 0
Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature 化学、物理和生物角膜脱细胞方法:文献综述
IF 1.9 4区 医学 Q2 Medicine Pub Date : 2024-03-25 DOI: 10.1155/2024/1191462
Alexandra Procházková, Martina Poláchová, Jakub Dítě, Magdaléna Netuková, Pavel Studený
The cornea is one of the most commonly transplanted tissues worldwide. It is used to restore vision when severe visual impairment or blindness occurs in patients with corneal diseases or after trauma. Due to the global shortage of healthy donor corneas, decellularized corneal tissue has significant potential as an alternative to corneal transplantation. It preserves the native and biological ultrastructure of the cornea and, therefore, represents the most promising scaffold. This article discusses different methods of corneal decellularization based on the current literature. We searched PubMed.gov for articles from January 2009 to December 2023 using the following keywords: corneal decellularization, decellularization methods, and corneal transplantation. Although several methods of decellularization of corneal tissue have been reported, a universal standardised protocol of corneal decellularization has not yet been introduced. In general, a combination of decellularization methods has been used for efficient decellularization while preserving the optimal properties of the corneal tissue.
角膜是全世界最常见的移植组织之一。当角膜疾病患者或外伤后出现严重视力障碍或失明时,角膜可用于恢复视力。由于全球缺乏健康的供体角膜,脱细胞角膜组织作为角膜移植的替代品具有巨大的潜力。脱细胞角膜组织保留了角膜的原生生物超微结构,因此是最有前途的支架。本文根据现有文献讨论了角膜脱细胞的不同方法。我们在PubMed.gov上搜索了2009年1月至2023年12月期间的文章,关键词如下:角膜脱细胞、脱细胞方法和角膜移植。虽然已有多种角膜组织脱细胞方法的报道,但目前还没有一个通用的角膜脱细胞标准化方案。一般来说,为了有效脱细胞,同时保留角膜组织的最佳特性,脱细胞方法已被结合使用。
{"title":"Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature","authors":"Alexandra Procházková, Martina Poláchová, Jakub Dítě, Magdaléna Netuková, Pavel Studený","doi":"10.1155/2024/1191462","DOIUrl":"https://doi.org/10.1155/2024/1191462","url":null,"abstract":"The cornea is one of the most commonly transplanted tissues worldwide. It is used to restore vision when severe visual impairment or blindness occurs in patients with corneal diseases or after trauma. Due to the global shortage of healthy donor corneas, decellularized corneal tissue has significant potential as an alternative to corneal transplantation. It preserves the native and biological ultrastructure of the cornea and, therefore, represents the most promising scaffold. This article discusses different methods of corneal decellularization based on the current literature. We searched PubMed.gov for articles from January 2009 to December 2023 using the following keywords: corneal decellularization, decellularization methods, and corneal transplantation. Although several methods of decellularization of corneal tissue have been reported, a universal standardised protocol of corneal decellularization has not yet been introduced. In general, a combination of decellularization methods has been used for efficient decellularization while preserving the optimal properties of the corneal tissue.","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140301221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Ophthalmology
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