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Long-term sexual outcomes in classic bladder exstrophy: Insights from standardized scores. 经典膀胱外翻的长期性结局:来自标准化评分的见解。
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-26 DOI: 10.1016/j.jpurol.2025.105713
Sarah Abdellaoui, Fabiana Cazzorla, Paul Neuville, Pierre D E Mouriquand, Valeska Bidault, Alain Ruffion, Nicolas Morel-Journel, Delphine Demède

Background: Reconstruction of the genitalia in patients with classic bladder exstrophy (CBE) is essential to support satisfactory sexual function and fertility. However, due to the complexity of both urinary and genital reconstructive procedures, long-term sexual function may be significantly impaired in adulthood.

Objectives: To assess long-term sexual outcomes and the prevalence of sexual and erectile dysfunctions in patients with classic bladder exstrophy (CBE). Secondary objectives were to identify predictive factors of sexual dysfunction and describe fertility outcomes.

Patients and methods: This retrospective single-center cohort study (part of QUALEXSTRO study) assessed sexuality and fertility in patients aged ≥15 years treated for CBE, using standardized and validated questionnaires: the Female Sexual Function Index (FSFI) for women and the Simplified International Index of Erectile Function (IIEF-5) for men.

Results: Among 63 eligible patients (36 men and 27 women), 22 men and 20 women completed the questionnaire. Median [IQR] age and follow-up were 28 [20-37] and 26 [19-35] years in women, and 23 [17-30] and 21 [16-27] years in men. Thirteen (65 %) women underwent genital surgery (median [IQR] age at first genital surgery: 14 [12-17] years). Among women, 13 (65 %) were sexually active, their median [IQR] age was 34 [27-40] years. Median [IQR] FSFI was 28.4 [14.2-30.1], with 42.6 % meeting criteria for sexual dysfunction (FSFI<26.55). In men, the Ransley-Cantwell technique was mainly used for epispadias repair; 63.6 % required additional urethral surgeries. Twelve men (54.5 %) were sexually active, with a median [IQR] age of 28 [21-37] years. Among them, median [IQR] IIEF-5 score was 23 [16.5-23], and 4 patients (33.3 %) had ED (IIEF-5<22). Satisfaction with genital appearance was low (37.5 % in women, 11.8 % in men). Among sexually active women, 66.7 % became pregnant; 7 delivered 9 children. One man fathered two children naturally.

Conclusions: Patients with CBE report high rates of sexual activity, but variable levels of satisfaction with genital appearance and sexual function. Standard scoring tools may not adequately reflect the specific anatomical and functional characteristics of this population, pointing out the need for adapted assessment instruments to evaluate surgical outcomes more accurately.

背景:典型膀胱外翻(CBE)患者的生殖器重建是支持满意的性功能和生育的必要条件。然而,由于泌尿和生殖器重建手术的复杂性,长期性功能可能在成年期受到严重损害。目的:评估典型膀胱外翻(CBE)患者的长期性结局以及性和勃起功能障碍的患病率。次要目的是确定性功能障碍的预测因素和描述生育结果。患者和方法:这项回顾性单中心队列研究(QUALEXSTRO研究的一部分)评估了年龄≥15岁的CBE患者的性行为和生育能力,使用标准化和有效的问卷:女性的女性性功能指数(FSFI)和男性的简化国际勃起功能指数(IIEF-5)。结果:63例符合条件的患者(男性36例,女性27例)中,男性22例,女性20例。中位[IQR]年龄及随访时间女性为28[20-37]、26[19-35]岁,男性为23[17-30]、21[16-27]岁。13名(65%)女性接受了生殖器手术(首次生殖器手术的中位年龄:14岁[12-17]岁)。在女性中,13例(65%)性活跃,她们的中位[IQR]年龄为34岁[27-40]。中位[IQR] FSFI为28.4[14.2-30.1],42.6%符合性功能障碍标准(FSFI)。结论:CBE患者报告性活动率高,但对生殖器外观和性功能的满意度水平不一。标准评分工具可能不能充分反映这一人群的具体解剖和功能特征,这表明需要适应的评估工具来更准确地评估手术结果。
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引用次数: 0
Effect of tele-nursing on parental anxiety and care satisfaction after circumcision: A quasi-experimental study 远程护理对包皮环切术后父母焦虑和护理满意度的影响:一项准实验研究
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-26 DOI: 10.1016/j.jpurol.2025.105708
Asiye Balki , Atiye Erbaş , Selin Keskin Kiziltepe

Introduction

Circumcision has been practised in almost every region of the world throughout human history for cultural, social, religious, and medical reasons. Although it is generally considered a simple procedure, studies have shown that parents of circumcised children often experience high levels of fear, anxiety, and worry during the process.

Objective

This study aimed to determine the effect of tele-nursing services provided to parents of circumcised children after discharge on their anxiety levels and satisfaction with care.

Materials and methods

This parallel-design, quasi-experimental study was conducted between November 2022 and July 2023 with 108 parents (54 in the intervention group and 54 in the control group) whose children had undergone circumcision. Participants were assigned to groups using the block randomisation method. The intervention group received tele-nursing follow-up after discharge, while the control group received routine discharge information only. Data collection tools included the participant information form, Beck Anxiety Scale, PedsQL Health Care Parental Satisfaction Scale, tele-nursing education content, and telephone counselling follow-up form. Data were analysed using non-parametric tests such as the chi-square, Mann–Whitney U, and Wilcoxon tests, with statistical significance set at p < 0.05.

Results

The final measurement of anxiety scores indicated that parents in the intervention group had significantly lower anxiety than those in the control group (Z = −5.206, p = 0.000). Similarly, the final parental care satisfaction scores were significantly higher in the intervention group than in the control group (Z = −4.957, p = 0.000).

Conclusion

These findings demonstrate that tele-nursing services provided to parents of circumcised children after discharge effectively reduced parental anxiety and increased satisfaction with care. It is recommended that clinical nurses be supported and encouraged to provide tele-nursing services to maintain continuity of postoperative care, particularly for follow-up and education after surgical procedures.
在整个人类历史上,由于文化、社会、宗教和医学原因,割礼几乎在世界每个地区都有实施。虽然割礼通常被认为是一个简单的过程,但研究表明,在这个过程中,孩子的父母经常会经历高度的恐惧、焦虑和担忧。目的探讨包皮环切术后父母出院后远程护理服务对其焦虑水平和护理满意度的影响。材料与方法这项平行设计的准实验研究于2022年11月至2023年7月对108名父母(干预组54名,对照组54名)的孩子进行了包皮环切术。参与者被分配到使用块随机化方法的组。干预组出院后接受远程护理随访,对照组仅接受出院常规信息。数据收集工具包括参与者信息表、Beck焦虑量表、PedsQL健康护理父母满意度量表、远程护理教育内容、电话咨询随访表。数据分析采用非参数检验,如卡方检验、Mann-Whitney U检验和Wilcoxon检验,p <; 0.05为统计学显著性。结果干预组家长焦虑总分明显低于对照组(Z = - 5.206, p = 0.000)。同样,干预组的最终亲代照顾满意度得分显著高于对照组(Z = - 4.957, p = 0.000)。结论为包皮环切术后患儿家长提供远程护理服务,可有效降低家长焦虑,提高护理满意度。建议支持和鼓励临床护士提供远程护理服务,以保持术后护理的连续性,特别是外科手术后的随访和教育。
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引用次数: 0
Response to Commentary on "Children with voiding dysfunction present deficits in motor performance". 对“排尿功能障碍儿童在运动表现上存在缺陷”评论的回应。
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-24 DOI: 10.1016/j.jpurol.2025.105706
Sabrina Orlandi Barbieri, Rita Pavione Rodrigues Pereira, Fernando Copetti, Nadia Cristina Valentini, Melissa Medeiros Braz
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引用次数: 0
Commentary to "Children with voiding dysfunction present deficits in motor performance". 对“有排尿功能障碍的儿童在运动表现上存在缺陷”的评论。
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-24 DOI: 10.1016/j.jpurol.2025.105707
Cristian Sager
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引用次数: 0
Laparoscopic pyeloplasty for pediatric UPJO: Clinical outcomes from five Arabian Gulf tertiary centers over ten years 腹腔镜肾盂成形术治疗儿童UPJO:来自五个阿拉伯海湾三级中心十年来的临床结果
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-24 DOI: 10.1016/j.jpurol.2025.105709
Adel Aljneibi , Hesham Soliman Safoury , Mohamed Hobeldin , Saif Abdelsalam , Abdulnaser Alsaid , Hamdan Alhazmi , Khalid Alali , Abdulrahman Almaghrabi , Nausheen Nasir , Sadikullah Khan , Ashhad Ali Khan , Ahmed Abdelhaseeb Youssef
<div><h3>Introduction</h3><div>Ureteropelvic junction obstruction (UPJO) is frequently identified in infancy due to routine prenatal screening. While many cases resolve, true obstructions require surgery to preserve renal function. Laparoscopic pyeloplasty has increasingly replaced open surgery, even in infants, though optimal timing and approach remain debated.</div></div><div><h3>Objective</h3><div>We report a 10-year multicenter experience with laparoscopic pyeloplasty in children across five tertiary centers in three Arabian Gulf countries.</div></div><div><h3>Study design</h3><div>A retrospective review of 422 patients (459 renal units) who underwent laparoscopic pyeloplasty from January 2014 to January 2024 was conducted. Demographic data, clinical presentation, investigative findings, surgical indications, intraoperative findings, and outcomes were retrieved from electronic records. Data were tabulated and examined for statistical significance.</div></div><div><h3>Results</h3><div>Mean age at surgery was 38 ± 46 months; 152 were <6 months and 230 < 12 months. Transperitoneal pyeloplasty was used in 443 renal units, retroperitoneoscopic in 16. Aberrant vessels (5.9 %), retrocaval ureters (0.4 %), and other anomalies (2.8 %) were identified. Seven patients had prior failed pyeloplasty (mostly open). Conversion to open surgery occurred in 2 cases (<1 %); no intraoperative complications were reported. Mean operative time was 209 ± 67 min, decreasing significantly over time (p < 0.001). Nine patients (2.6 %) required redo pyeloplasty. Ultrasound outperformed MAG3 in predicting failure (sensitivity/specificity: 94 %/100 % vs 91 %/90 %).</div></div><div><h3>Discussion</h3><div>Laparoscopic pyeloplasty has become increasingly accepted, including for infants, as surgical expertise and familiarity with minimally invasive techniques have improved. Our multicenter series of 459 renal units represents one of the largest reported and affirms the safety and efficacy of laparoscopic pyeloplasty across a broad patient population. A substantial proportion of our patients were treated early in life, with 36 % under 6 months and 55 % under 12 months. Although younger age was historically considered a limitation, our findings support previous reports that younger infants can be safely and effectively managed laparoscopically in experienced hands. This study is limited by its retrospective nature and lack of a comparator group undergoing open pyeloplasty. However, as the field moves forward, future studies will likely focus on comparative outcomes between laparoscopic and robotic pyeloplasty rather than the open approach.</div></div><div><h3>Conclusion</h3><div>Laparoscopic pyeloplasty is safe and effective in infants and children, including redo and anatomically complex cases. Both transperitoneal and retroperitoneoscopic approaches yield excellent outcomes. Ultrasound is a reliable follow-up tool, potentially reducing reliance on radionuclide imag
导读:输尿管肾盂连接处梗阻(UPJO)经常在婴儿期被发现,因为常规的产前筛查。虽然许多病例可以解决,但真正的梗阻需要手术来保护肾功能。腹腔镜肾盂成形术越来越多地取代开放手术,即使在婴儿中也是如此,尽管最佳时机和方法仍存在争议。目的:我们报告了在三个阿拉伯海湾国家的五个三级中心对儿童进行腹腔镜肾盂成形术的10年多中心经验。研究设计回顾性分析2014年1月至2024年1月行腹腔镜肾盂成形术的422例患者(459肾单位)。从电子记录中检索人口统计数据、临床表现、调查结果、手术指征、术中发现和结果。将数据制成表格并检验统计显著性。结果平均手术年龄38±46个月;6个月的152例,12个月的230例。443个肾单位采用经腹膜肾盂成形术,16个肾单位采用后腹膜镜。异常血管(5.9%)、腔静脉后输尿管(0.4%)和其他异常(2.8%)被发现。7例患者既往肾盂成形术失败(多数为开放)。2例转为开放手术(< 1%);无术中并发症报道。平均手术时间为209±67 min,随时间推移显著缩短(p < 0.001)。9例(2.6%)患者需要重新进行肾盂成形术。超声在预测失败方面优于MAG3(敏感性/特异性:94% / 100% vs 91% / 90%)。腹腔镜肾盂成形术越来越被接受,包括婴儿,随着手术专业知识和对微创技术的熟悉程度的提高。我们的459个肾单元的多中心系列是最大的报道之一,并在广泛的患者群体中证实了腹腔镜肾盂成形术的安全性和有效性。我们的患者中有很大一部分在生命早期接受了治疗,其中36%在6个月以下,55%在12个月以下。虽然年龄较小历来被认为是一个限制,但我们的研究结果支持先前的报道,即年龄较小的婴儿可以在经验丰富的人手中安全有效地进行腹腔镜手术。这项研究的局限性在于它是回顾性的,并且缺乏进行开放式肾盂成形术的比较组。然而,随着该领域的发展,未来的研究可能会集中在腹腔镜肾盂成形术和机器人肾盂成形术之间的比较结果,而不是开放式方法。结论腹腔镜肾盂成形术对婴幼儿安全有效,包括重做和解剖复杂的病例。经腹膜和后腹膜镜入路均可获得良好的结果。超声是一种可靠的随访工具,可能减少对放射性核素成像的依赖。
{"title":"Laparoscopic pyeloplasty for pediatric UPJO: Clinical outcomes from five Arabian Gulf tertiary centers over ten years","authors":"Adel Aljneibi ,&nbsp;Hesham Soliman Safoury ,&nbsp;Mohamed Hobeldin ,&nbsp;Saif Abdelsalam ,&nbsp;Abdulnaser Alsaid ,&nbsp;Hamdan Alhazmi ,&nbsp;Khalid Alali ,&nbsp;Abdulrahman Almaghrabi ,&nbsp;Nausheen Nasir ,&nbsp;Sadikullah Khan ,&nbsp;Ashhad Ali Khan ,&nbsp;Ahmed Abdelhaseeb Youssef","doi":"10.1016/j.jpurol.2025.105709","DOIUrl":"10.1016/j.jpurol.2025.105709","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Ureteropelvic junction obstruction (UPJO) is frequently identified in infancy due to routine prenatal screening. While many cases resolve, true obstructions require surgery to preserve renal function. Laparoscopic pyeloplasty has increasingly replaced open surgery, even in infants, though optimal timing and approach remain debated.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;We report a 10-year multicenter experience with laparoscopic pyeloplasty in children across five tertiary centers in three Arabian Gulf countries.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study design&lt;/h3&gt;&lt;div&gt;A retrospective review of 422 patients (459 renal units) who underwent laparoscopic pyeloplasty from January 2014 to January 2024 was conducted. Demographic data, clinical presentation, investigative findings, surgical indications, intraoperative findings, and outcomes were retrieved from electronic records. Data were tabulated and examined for statistical significance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Mean age at surgery was 38 ± 46 months; 152 were &lt;6 months and 230 &lt; 12 months. Transperitoneal pyeloplasty was used in 443 renal units, retroperitoneoscopic in 16. Aberrant vessels (5.9 %), retrocaval ureters (0.4 %), and other anomalies (2.8 %) were identified. Seven patients had prior failed pyeloplasty (mostly open). Conversion to open surgery occurred in 2 cases (&lt;1 %); no intraoperative complications were reported. Mean operative time was 209 ± 67 min, decreasing significantly over time (p &lt; 0.001). Nine patients (2.6 %) required redo pyeloplasty. Ultrasound outperformed MAG3 in predicting failure (sensitivity/specificity: 94 %/100 % vs 91 %/90 %).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;Laparoscopic pyeloplasty has become increasingly accepted, including for infants, as surgical expertise and familiarity with minimally invasive techniques have improved. Our multicenter series of 459 renal units represents one of the largest reported and affirms the safety and efficacy of laparoscopic pyeloplasty across a broad patient population. A substantial proportion of our patients were treated early in life, with 36 % under 6 months and 55 % under 12 months. Although younger age was historically considered a limitation, our findings support previous reports that younger infants can be safely and effectively managed laparoscopically in experienced hands. This study is limited by its retrospective nature and lack of a comparator group undergoing open pyeloplasty. However, as the field moves forward, future studies will likely focus on comparative outcomes between laparoscopic and robotic pyeloplasty rather than the open approach.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Laparoscopic pyeloplasty is safe and effective in infants and children, including redo and anatomically complex cases. Both transperitoneal and retroperitoneoscopic approaches yield excellent outcomes. Ultrasound is a reliable follow-up tool, potentially reducing reliance on radionuclide imag","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"22 1","pages":"Article 105709"},"PeriodicalIF":1.9,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing associations of clinical factors and feeding practices with infantile urolithiasis: Insights from a nationwide study 评估临床因素和喂养方法与婴儿尿石症的关联:来自一项全国性研究的见解
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-23 DOI: 10.1016/j.jpurol.2025.105705
Serra Sürmeli Döven , Esra Genç , Aylin Gençler , Özgür Özdemir Şimşek , Ali Tunç , Fatma Mutlubaş , Güldane Aylin İnal , Rümeysa Yasemin Çiçek , Yeşim Özdemir Atikel , Güneş Işık , Fatma Şemsa Çaycı , Çınar Özen , Hülya Gözde Önal , Gizem Yıldız , Ozan Karakaş , Pelin Ertan , Ayşe Ağbaş , Ahmet Midhat Elmacı , Funda Baştuğ , Burcu Ayvacı , Harika Alpay

Introduction

The incidence of infantile urolithiasis (IU) has been rising, attributed to factors such as climate change, the widespread use of ultrasonography, dehydration, and alterations in nutritional practices. Studies investigating the influence of infant feeding practices on stone formation remain limited.

Objectives

This study aims to identify the risk factors associated with stone formation in infants and to evaluate whether formula feeding influence the development of IU.

Study design

Infants aged 1–12 months who were diagnosed with IU and followed up at pediatric nephrology clinics in 19 centers across Türkiye between January 2022 and January 2024 were included in the patient group. Healthy infants served as the control group. A structured questionnaire assessing nutritional, demographic, and clinical characteristics was administered to both groups. A comparative analysis was conducted between the patient and control groups.

Results

Among the 1.094 infants included in the study, 45.7 % (n = 500) comprised the patient group, while 54.3 % (n = 594) were in the control group. A history of urinary tract infection, family history of urolithiasis and stone surgery, and vitamin D supplementation were significantly more common in the patient group compared to the control group (p = 0.006, <0.001, <0.001, and <0.001, respectively). Urine densities ranging from 1010 to 1020, as well as those greater than 1020, were more frequently observed in the patient group than in the control group (30.3 % vs. 20.1 % and 5.9 % vs. 0.4 %, respectively. Exclusively formula feeding (OR = 1.96 [1.094–3.521], p = 0.024), vitamin D consumption (OR = 3.994 [2.348–6.793], p < 0.001), and a family history of stone surgery (OR = 2.423 [1.457–4.027], p = 0.001), were identified as independent risk factors for stone formation.

Discussion

Türkiye is an endemic region for urolithiasis due to factors such as a high animal-based diet and a hot climate. Urolithiasis is reported to affect 10–20 % of children, with infantile urolithiasis accounting for 9–23 % of this incidence. This study represents the largest case series on infantile urolithiasis, investigating the impact of nutrition on its development.

Conclusions

Exclusive breastfeeding should be encouraged, as it serves as a protective factor against stone formation in infants. Preventing dehydration is also essential. Infants receiving vitamin D supplementation, as well as those with a family history of urolithiasis or stone surgery, should be closely monitored for the potential development of urinary stones.
婴儿尿石症(IU)的发病率一直在上升,原因包括气候变化、超声检查的广泛使用、脱水和营养习惯的改变。调查婴儿喂养方式对结石形成影响的研究仍然有限。目的本研究旨在确定婴儿结石形成的相关危险因素,并评估配方奶喂养是否影响IU的发展。研究设计将2022年1月至2024年1月期间在全国19个中心的儿科肾脏病诊所诊断为IU并随访的1-12个月大的婴儿纳入患者组。以健康婴儿为对照组。对两组进行营养、人口统计学和临床特征评估的结构化问卷调查。在患者和对照组之间进行比较分析。结果纳入研究的1.094例患儿中,患者组占45.7% (n = 500),对照组占54.3% (n = 594)。与对照组相比,患者组尿路感染史、尿石症家族史和结石手术史以及补充维生素D的发生率显著高于对照组(p = 0.006, <0.001, <;0.001和<;0.001)。尿密度范围在1010到1020之间以及大于1020的尿密度在患者组中比对照组更常见(分别为30.3%比20.1%和5.9%比0.4%)。纯配方奶喂养(OR = 1.96 [1.094-3.521], p = 0.024)、维生素D摄入(OR = 3.994 [2.348-6.793], p < 0.001)和结石手术家族史(OR = 2.423 [1.457-4.027], p = 0.001)被认为是结石形成的独立危险因素。由于高动物性饮食和炎热气候等因素,冰岛是尿石症的流行地区。据报道,尿石症影响10 - 20%的儿童,其中婴儿尿石症占9 - 23%。这项研究是关于婴儿尿石症的最大的病例系列,调查营养对其发展的影响。结论应鼓励纯母乳喂养,因为纯母乳喂养是防止婴儿结石形成的保护因素。防止脱水也很重要。接受维生素D补充的婴儿,以及那些有尿石症家族史或结石手术的婴儿,应密切监测尿石的潜在发展。
{"title":"Assessing associations of clinical factors and feeding practices with infantile urolithiasis: Insights from a nationwide study","authors":"Serra Sürmeli Döven ,&nbsp;Esra Genç ,&nbsp;Aylin Gençler ,&nbsp;Özgür Özdemir Şimşek ,&nbsp;Ali Tunç ,&nbsp;Fatma Mutlubaş ,&nbsp;Güldane Aylin İnal ,&nbsp;Rümeysa Yasemin Çiçek ,&nbsp;Yeşim Özdemir Atikel ,&nbsp;Güneş Işık ,&nbsp;Fatma Şemsa Çaycı ,&nbsp;Çınar Özen ,&nbsp;Hülya Gözde Önal ,&nbsp;Gizem Yıldız ,&nbsp;Ozan Karakaş ,&nbsp;Pelin Ertan ,&nbsp;Ayşe Ağbaş ,&nbsp;Ahmet Midhat Elmacı ,&nbsp;Funda Baştuğ ,&nbsp;Burcu Ayvacı ,&nbsp;Harika Alpay","doi":"10.1016/j.jpurol.2025.105705","DOIUrl":"10.1016/j.jpurol.2025.105705","url":null,"abstract":"<div><h3>Introduction</h3><div>The incidence of infantile urolithiasis (IU) has been rising, attributed to factors such as climate change, the widespread use of ultrasonography, dehydration, and alterations in nutritional practices. Studies investigating the influence of infant feeding practices on stone formation remain limited.</div></div><div><h3>Objectives</h3><div>This study aims to identify the risk factors associated with stone formation in infants and to evaluate whether formula feeding influence the development of IU.</div></div><div><h3>Study design</h3><div>Infants aged 1–12 months who were diagnosed with IU and followed up at pediatric nephrology clinics in 19 centers across Türkiye between January 2022 and January 2024 were included in the patient group. Healthy infants served as the control group. A structured questionnaire assessing nutritional, demographic, and clinical characteristics was administered to both groups. A comparative analysis was conducted between the patient and control groups.</div></div><div><h3>Results</h3><div>Among the 1.094 infants included in the study, 45.7 % (n = 500) comprised the patient group, while 54.3 % (n = 594) were in the control group. A history of urinary tract infection, family history of urolithiasis and stone surgery, and vitamin D supplementation were significantly more common in the patient group compared to the control group (p = 0.006, &lt;0.001, &lt;0.001, and &lt;0.001, respectively). Urine densities ranging from 1010 to 1020, as well as those greater than 1020, were more frequently observed in the patient group than in the control group (30.3 % vs. 20.1 % and 5.9 % vs. 0.4 %, respectively. Exclusively formula feeding (OR = 1.96 [1.094–3.521], p = 0.024), vitamin D consumption (OR = 3.994 [2.348–6.793], p &lt; 0.001), and a family history of stone surgery (OR = 2.423 [1.457–4.027], p = 0.001), were identified as independent risk factors for stone formation.</div></div><div><h3>Discussion</h3><div>Türkiye is an endemic region for urolithiasis due to factors such as a high animal-based diet and a hot climate. Urolithiasis is reported to affect 10–20 % of children, with infantile urolithiasis accounting for 9–23 % of this incidence. This study represents the largest case series on infantile urolithiasis, investigating the impact of nutrition on its development.</div></div><div><h3>Conclusions</h3><div>Exclusive breastfeeding should be encouraged, as it serves as a protective factor against stone formation in infants. Preventing dehydration is also essential. Infants receiving vitamin D supplementation, as well as those with a family history of urolithiasis or stone surgery, should be closely monitored for the potential development of urinary stones.</div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"22 1","pages":"Article 105705"},"PeriodicalIF":1.9,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of deep learning for measurement of penile curvature on real 2D intraoperative images 在实际二维术中图像上实现阴茎曲率测量的深度学习
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-23 DOI: 10.1016/j.jpurol.2025.105703
Sriman Bidhan Baray , Saidanvar Agzamkhodjaev , Mansour Ali , Muhammad E.H. Chowdhury , Tariq O. Abbas

Background

Penile curvature (PC) may occur in up to 10 % of male births worldwide and is typically associated with the birth defect hypospadias. While the extent of PC impacts surgical management and patient outcomes, curvature evaluation is inconsistent between surgeons due to a lack of reliable assessment techniques. Our goal was to create a dependable, automated deep-learning solution to precisely assess PC from real-time intraoperative 2D images.

Materials and methods

A dataset of 421 images was assembled and annotated by four human experts. Annotations were used to calculate PC angles and determine ground truth curvature degrees in each case. All images and ground truth angle information were used to train 3 different deep-learning models. A YOLOv8 model was trained to localize and crop the penile region, then a deep-learning model was employed to segment the shafts and generate binary mask images. In the final stage, a modified HRNet model was used to integrate angle error, predict four key points denoting mid-axes of the proximal and distal shaft, and then use these landmarks to calculate curvature automatically.

Results

The proposed system demonstrated a high level of reliability in localizing penile areas, as evidenced by a mean average precision score of 99.4 %. Furthermore, our pipeline exhibited strong performance in the segmentation task, achieving an impressive Intersection over the Union metric of 83.56 % and a Dice Similarity Coefficient of 91.02 %. In terms of angle prediction, the system achieved a mean absolute error of 7.9°. By comparison, variability among human raters ranged between 6.5 and 12.0° (median ≈ 8.9°), consistent with previously reported manual errors of 3.5–13.6°. Thus, the AI system matched or outperformed human raters, providing more consistent and reliable curvature estimation. The model achieved a median error of 7.8° across 421 images, with 82 % of predictions within ±10° of ground truth. Only 6 % of cases crossed the 30° surgical threshold, confirming the tool's reliability for clinical decision-making.

Discussion

This study demonstrates the successful implementation of deep learning and keypoint-based measurement of PC that could significantly improve patient assessment by surgeons and hypospadiology researchers.
背景:阴茎弯曲(PC)可能发生在世界范围内高达10%的男性新生儿中,通常与尿道下裂的出生缺陷有关。虽然PC的程度影响手术治疗和患者预后,但由于缺乏可靠的评估技术,外科医生之间的曲率评估不一致。我们的目标是创建一个可靠的、自动化的深度学习解决方案,从实时术中2D图像中精确评估PC。材料与方法由4位人工专家对421张图像的数据集进行整理和注释。在每种情况下,使用注释计算PC角并确定地面真曲率度。使用所有图像和地面真角信息训练3种不同的深度学习模型。首先训练YOLOv8模型对阴茎区域进行定位和裁剪,然后利用深度学习模型对轴进行分割,生成二值蒙版图像。最后,利用改进的HRNet模型对角度误差进行积分,预测出代表近端和远端轴中轴的4个关键点,并利用这些关键点自动计算曲率。结果该系统在阴茎区域定位方面具有较高的可靠性,平均准确率为99.4%。此外,我们的管道在分割任务中表现出很强的性能,在Union度量上实现了令人印象深刻的交叉点83.56%,骰子相似系数为91.02%。在角度预测方面,系统的平均绝对误差为7.9°。相比之下,人类评分者的变异范围在6.5°至12.0°(中位数≈8.9°)之间,与先前报道的3.5°至13.6°的人工误差一致。因此,人工智能系统匹配或优于人类评分者,提供更一致和可靠的曲率估计。该模型在421张图像中实现了7.8°的中位误差,82%的预测在地面真实度的±10°范围内。只有6%的病例超过了30°手术阈值,证实了该工具在临床决策中的可靠性。本研究展示了深度学习和基于关键点的PC测量的成功实施,可以显著改善外科医生和尿道下裂学研究人员对患者的评估。
{"title":"Implementation of deep learning for measurement of penile curvature on real 2D intraoperative images","authors":"Sriman Bidhan Baray ,&nbsp;Saidanvar Agzamkhodjaev ,&nbsp;Mansour Ali ,&nbsp;Muhammad E.H. Chowdhury ,&nbsp;Tariq O. Abbas","doi":"10.1016/j.jpurol.2025.105703","DOIUrl":"10.1016/j.jpurol.2025.105703","url":null,"abstract":"<div><h3>Background</h3><div>Penile curvature (PC) may occur in up to 10 % of male births worldwide and is typically associated with the birth defect hypospadias. While the extent of PC impacts surgical management and patient outcomes, curvature evaluation is inconsistent between surgeons due to a lack of reliable assessment techniques. Our goal was to create a dependable, automated deep-learning solution to precisely assess PC from real-time intraoperative 2D images.</div></div><div><h3>Materials and methods</h3><div>A dataset of 421 images was assembled and annotated by four human experts. Annotations were used to calculate PC angles and determine ground truth curvature degrees in each case. All images and ground truth angle information were used to train 3 different deep-learning models. A YOLOv8 model was trained to localize and crop the penile region, then a deep-learning model was employed to segment the shafts and generate binary mask images. In the final stage, a modified HRNet model was used to integrate angle error, predict four key points denoting mid-axes of the proximal and distal shaft, and then use these landmarks to calculate curvature automatically.</div></div><div><h3>Results</h3><div>The proposed system demonstrated a high level of reliability in localizing penile areas, as evidenced by a mean average precision score of 99.4 %. Furthermore, our pipeline exhibited strong performance in the segmentation task, achieving an impressive Intersection over the Union metric of 83.56 % and a Dice Similarity Coefficient of 91.02 %. In terms of angle prediction, the system achieved a mean absolute error of 7.9°. By comparison, variability among human raters ranged between 6.5 and 12.0° (median ≈ 8.9°), consistent with previously reported manual errors of 3.5–13.6°. Thus, the AI system matched or outperformed human raters, providing more consistent and reliable curvature estimation. The model achieved a median error of 7.8° across 421 images, with 82 % of predictions within ±10° of ground truth. Only 6 % of cases crossed the 30° surgical threshold, confirming the tool's reliability for clinical decision-making.</div></div><div><h3>Discussion</h3><div>This study demonstrates the successful implementation of deep learning and keypoint-based measurement of PC that could significantly improve patient assessment by surgeons and hypospadiology researchers.</div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"22 2","pages":"Article 105703"},"PeriodicalIF":1.9,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146081022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Commentary on "Laparoscopic single-stage orchidopexy followed by groin exploration: the best two-stage orchidopexy?" 对“腹腔镜单阶段睾丸切除术后腹股沟探查:最佳的两阶段睾丸切除术是什么?”
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-22 DOI: 10.1016/j.jpurol.2025.105701
Karim Awad, Mohamed Sameh Shalaby, Laura Jackson, Mark N Woodward
{"title":"Response to Commentary on \"Laparoscopic single-stage orchidopexy followed by groin exploration: the best two-stage orchidopexy?\"","authors":"Karim Awad, Mohamed Sameh Shalaby, Laura Jackson, Mark N Woodward","doi":"10.1016/j.jpurol.2025.105701","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.105701","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"105701"},"PeriodicalIF":1.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glomerular Filtration Rate (GFR) measures in young children with cloacal malformations indicate early baseline renal dysfunction which is independently associated with congenital upper urinary tract anomalies 肾小球滤过率(GFR)的测量表明早期基线肾功能障碍与先天性上尿路异常独立相关
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-22 DOI: 10.1016/j.jpurol.2025.105704
Christopher Staniorski , Christopher Corbett , Butool Hisam , Melanie Bowser , Allison Mayhew , Christina P. Ho , Hans G. Pohl , Christina Feng , Andrea Badillo , Marc A. Levitt , Melissa R. Meyers , Briony K. Varda

Background

Children with cloacal malformations have high rates of congenital anomalies of the genitourinary tract, voiding dysfunction and subsequent renal dysfunction. Rigorous study of early renal function in this population has not been previously published.

Objective

We aimed to characterize the baseline renal function of this cohort in early childhood and identify demographic, clinical and anatomical factors associated with lower baseline renal function.

Study design

A prospectively maintained institutional database of patients with cloaca enrolled between 2020 and 2025 was used to track those undergoing primary repair or revision. Patients were excluded if they had missing post-operative renal function measurements or a primary diagnosis of cloacal exstrophy. The primary outcome was estimated glomerular filtration rate (eGFR).

Results

52 patients met inclusion criteria. The median age at initial evaluation was 0.8 years (range 0.1–10.1) while the median age at last follow up was 1.6 years (range 0.3–10.3). Anatomic characteristics included 21 (40 %) with a complex cloaca (common channel [CC] length ≥3 cm), 26 (50 %) born with hydrocolpos, 48 (92 %) with an upper urinary tract anomaly (UTA) and 23 (44 %) with a severe UTA (defined as high grade hydroureteronephrosis [SFU grade 4], vesicoureteral reflux [grade IV-V] and/or solitary kidney with an ipsilateral anomaly). The median eGFR at the most recent evaluation was 82 ml/min/1.73 m2 (IQR 64–101). 30 patients (58 %) had at least chronic kidney disease (CKD) stage 2, but only 4 (8 %) had CKD stage 3b or greater. In unadjusted analyses, public insurance, increasing CC length, decreasing urethral length, urethral atresia, and upper UTAs were associated with decreased eGFR. Only public insurance status and severe UTAs were independently associated with decreased eGFR.

Discussion

While many elements of cloacal anatomy were associated with eGFR, on adjusted analysis, only severe upper UTAs and insurance status remained associated. These data capture a relatively young cohort and suggest that early renal dysfunction is driven by congenital renal anomalies. Patients may develop voiding dysfunction and/or urinary tract infections that potentiate renal disease in this context. However, patients may also have intrinsic renal disease that is unmasked with somatic growth in late childhood and adolescence. Both scenarios must be anticipated and managed.

Conclusions

This study affirms a high rate of early renal dysfunction in this population and identifies renal anomalies as an important anatomic factor. These results emphasize the need for careful bladder management and renal surveillance protocols to reduce progression of renal disease.
背景:儿童期肛管畸形有较高的先天性泌尿生殖道异常、排尿功能障碍和继发肾功能障碍的发生率。对这一人群早期肾功能的严格研究尚未发表。目的:我们旨在描述该队列儿童早期基线肾功能的特征,并确定与较低基线肾功能相关的人口统计学、临床和解剖学因素。研究设计采用前瞻性维护的机构数据库,纳入2020年至2025年期间的泄殖腔患者,以跟踪接受初级修复或翻修的患者。如果患者术后肾功能测量缺失或初步诊断为肛管外翻,则排除。主要终点是估计肾小球滤过率(eGFR)。结果52例患者符合纳入标准。初始评估时的中位年龄为0.8岁(范围0.1-10.1),最后随访时的中位年龄为1.6岁(范围0.3-10.3)。解剖特征包括21例(40%)伴有复杂泄水沟(总通道长度≥3cm), 26例(50%)先天性肠积水,48例(92%)伴有上尿路异常(UTA), 23例(44%)伴有严重UTA(定义为高级别输尿管积水[SFU 4级],膀胱输尿管反流[IV-V级]和/或同侧异常的孤立肾)。最近一次评估的中位eGFR为82 ml/min/1.73 m2 (IQR 64-101)。30名患者(58%)至少患有慢性肾脏疾病(CKD) 2期,但只有4名患者(8%)患有CKD 3b期或以上。在未经调整的分析中,公共保险、CC长度增加、尿道长度减少、尿道闭锁和上UTAs与eGFR下降有关。只有公共保险状况和严重uta与eGFR下降独立相关。虽然许多肛管解剖因素与eGFR相关,但在调整分析中,只有严重的上uta和保险状况仍然相关。这些数据捕获了一个相对年轻的队列,并提示早期肾功能障碍是由先天性肾异常驱动的。在这种情况下,患者可能会出现排尿功能障碍和/或尿路感染,从而加剧肾脏疾病。然而,患者也可能有内在的肾脏疾病,在儿童期晚期和青春期的躯体生长中被发现。必须预测和管理这两种情况。结论本研究证实了该人群早期肾功能不全的高发率,并确定肾脏异常是一个重要的解剖因素。这些结果强调需要仔细的膀胱管理和肾脏监测方案,以减少肾脏疾病的进展。
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引用次数: 0
Commentary to "Laparoscopic single-stage orchidopexy followed by groin exploration: the best two-stage orchidopexy?" 对“腹腔镜单阶段睾丸切除术后腹股沟探查:最好的两阶段睾丸切除术是什么?”
IF 1.9 3区 医学 Q2 PEDIATRICS Pub Date : 2025-12-21 DOI: 10.1016/j.jpurol.2025.105702
Amr Hodhod, Wael M Moneir
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引用次数: 0
期刊
Journal of Pediatric Urology
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