Pub Date : 2026-03-02DOI: 10.1007/s13105-026-01163-5
Jing Hu, Xi Jiang, Mingxing Ding, Sang Ki Lee, Lifeng Wang, Ting Li, Wei Li, Mallikarjuna Korivi
{"title":"Exercise reverses high-fat diet-induced perivascular adipose tissue dysfunction through modulation of UCP2 and TXNIP/NLRP3 pathways.","authors":"Jing Hu, Xi Jiang, Mingxing Ding, Sang Ki Lee, Lifeng Wang, Ting Li, Wei Li, Mallikarjuna Korivi","doi":"10.1007/s13105-026-01163-5","DOIUrl":"https://doi.org/10.1007/s13105-026-01163-5","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-02DOI: 10.1007/s13105-026-01156-4
Jiamei Zhang, Mengmeng Tang, Min Yu
{"title":"Research progress of ferroptosis in obesity and its complications.","authors":"Jiamei Zhang, Mengmeng Tang, Min Yu","doi":"10.1007/s13105-026-01156-4","DOIUrl":"https://doi.org/10.1007/s13105-026-01156-4","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-28DOI: 10.1007/s13105-026-01155-5
Lucas Jurado-Fasoli, Borja Martinez-Tellez, Isabelle Kohler, Jonatan R Ruiz, Francisco J Osuna-Prieto
{"title":"Changes in circulating bile acid levels during cold exposure are associated with brown adipose tissue in humans: a secondary analysis from the ACTIBATE study.","authors":"Lucas Jurado-Fasoli, Borja Martinez-Tellez, Isabelle Kohler, Jonatan R Ruiz, Francisco J Osuna-Prieto","doi":"10.1007/s13105-026-01155-5","DOIUrl":"10.1007/s13105-026-01155-5","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Necroptosis is a regulated form of cell death characterized by receptor-interacting protein kinase (RIPK) activation, leading to necrosome formation and subsequent membrane rupture. Increasing evidence indicates that necroptosis contributes to metabolic syndrome (MetS) by promoting tissue inflammation, insulin resistance, and metabolic dysfunction. The molecular mechanisms underlying necroptosis in MetS primarily involve activation of the RIPK1-RIPK3-MLKL axis, particularly in metabolically active tissues such as skeletal muscle, liver, adipose tissue, and pancreatic β-cells. Although numerous experimental studies have linked necroptosis to metabolic inflammation and organ injury, a systematic synthesis of its mechanistic roles, biomarker relevance, and translational potential in MetS remains limited. This review summarizes current evidence on the molecular regulation of necroptosis in MetS, its involvement in disease progression across multiple organs, and emerging diagnostic, prognostic, and theragnostic biomarkers. In addition, this review discusses therapeutic strategies targeting necroptosis and critically evaluates their translational challenges. By integrating mechanistic and translational perspectives, this review aims to provide a balanced framework for understanding the role of necroptosis in MetS and to highlight key knowledge gaps that warrant further investigation.
{"title":"Metabolic syndrome necroptosis: disease implications and therapeutic targeting.","authors":"Jiaenli Bolati, Ahequeli Gemingnuer, Fang Lu, Yueqi Yan, Donghua Yu, Chunmiao Yu","doi":"10.1007/s13105-026-01161-7","DOIUrl":"10.1007/s13105-026-01161-7","url":null,"abstract":"<p><p>Necroptosis is a regulated form of cell death characterized by receptor-interacting protein kinase (RIPK) activation, leading to necrosome formation and subsequent membrane rupture. Increasing evidence indicates that necroptosis contributes to metabolic syndrome (MetS) by promoting tissue inflammation, insulin resistance, and metabolic dysfunction. The molecular mechanisms underlying necroptosis in MetS primarily involve activation of the RIPK1-RIPK3-MLKL axis, particularly in metabolically active tissues such as skeletal muscle, liver, adipose tissue, and pancreatic β-cells. Although numerous experimental studies have linked necroptosis to metabolic inflammation and organ injury, a systematic synthesis of its mechanistic roles, biomarker relevance, and translational potential in MetS remains limited. This review summarizes current evidence on the molecular regulation of necroptosis in MetS, its involvement in disease progression across multiple organs, and emerging diagnostic, prognostic, and theragnostic biomarkers. In addition, this review discusses therapeutic strategies targeting necroptosis and critically evaluates their translational challenges. By integrating mechanistic and translational perspectives, this review aims to provide a balanced framework for understanding the role of necroptosis in MetS and to highlight key knowledge gaps that warrant further investigation.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-26DOI: 10.1007/s13105-026-01157-3
Candela L Suppo, Gisela N Kuhn, Jimena V Lavandera, Claudio A Bernal, Ana C Fariña
{"title":"Combined functional lipids modulate lipid metabolism and attenuate metabolic dysregulation in a rat model of cafeteria diet.","authors":"Candela L Suppo, Gisela N Kuhn, Jimena V Lavandera, Claudio A Bernal, Ana C Fariña","doi":"10.1007/s13105-026-01157-3","DOIUrl":"https://doi.org/10.1007/s13105-026-01157-3","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147290301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-18DOI: 10.1007/s13105-026-01158-2
Kyung-Wan Baek, Jong-Hwa Won, Ying-Ying Xiang, Dong Kyun Woo, Yoonjung Park, Ji-Seok Kim
{"title":"Concurrent initiation of treadmill exercise protects against angiotensin II-induced renal injury by modulating oxidative stress and autophagy in mice.","authors":"Kyung-Wan Baek, Jong-Hwa Won, Ying-Ying Xiang, Dong Kyun Woo, Yoonjung Park, Ji-Seok Kim","doi":"10.1007/s13105-026-01158-2","DOIUrl":"10.1007/s13105-026-01158-2","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":"13"},"PeriodicalIF":4.3,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1007/s13105-026-01154-6
Patricia Aragón-Espinosa, Patricia Pérez-Matute, Catherine Bompart, Marine Gueugneau, Frederic Capel, Jose M Arbones-Mainar, Saioa Gomez-Zorita, Anna Mas-Capdevila, Xavier Escoté, Montserrat Pinent, Anna Ardévol
{"title":"From molecular mechanisms to nutritional applications: protein and polyphenol interventions in sarcopenia.","authors":"Patricia Aragón-Espinosa, Patricia Pérez-Matute, Catherine Bompart, Marine Gueugneau, Frederic Capel, Jose M Arbones-Mainar, Saioa Gomez-Zorita, Anna Mas-Capdevila, Xavier Escoté, Montserrat Pinent, Anna Ardévol","doi":"10.1007/s13105-026-01154-6","DOIUrl":"10.1007/s13105-026-01154-6","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":"12"},"PeriodicalIF":4.3,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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